With Sample Or Reagent Mechanical Transport Means Patents (Class 435/287.3)
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Patent number: 8906674Abstract: A sample preparation apparatus comprising: a storage chamber that can store therein a liquid sample including an analysis target to be analyzed; a concentrated sample storage chamber that is provided to communicate with the storage chamber and that stores therein concentrated liquid having an analysis target having a higher concentration than that of the liquid sample; and an analysis target transportation section for transporting the analysis target included in the liquid sample stored in the storage chamber to the concentrated sample storage chamber. A cell analyzer is also disclosed.Type: GrantFiled: September 29, 2010Date of Patent: December 9, 2014Assignee: Sysmex CorporationInventors: Ryuichiro Ebi, Koki Tajima
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Patent number: 8906302Abstract: A reagent preparing device for preparing a reagent to be supplied to a measurement device for measuring a specimen, comprising: a first liquid storage unit for storing a first liquid; a reagent storage unit for storing a prepared reagent, including the first liquid and a second liquid different from the first liquid; a first liquid discarding unit for discarding the first liquid stored in the first liquid storage unit; and a controller configured for measuring an accumulated time of the first liquid in the first liquid storage unit; and controlling the first liquid discarding unit to discard the first liquid stored in the first liquid storage unit when the accumulated time reaches a predetermined time is disclosed. A specimen measuring device and a reagent preparing method are also disclosed.Type: GrantFiled: February 24, 2010Date of Patent: December 9, 2014Assignee: Sysmex CorporationInventors: Noriyuki Nakanishi, Koichi Okubo, Masahiko Oguro, Tomoyuki Asahara
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Publication number: 20140356876Abstract: In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue, capturing the sectioned tissue, and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, and capturing each sectioned tissue, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest.Type: ApplicationFiled: June 10, 2014Publication date: December 4, 2014Inventor: Timothy Ragan
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Patent number: 8895312Abstract: A microfluidic device for mitochondria analysis includes an inlet coupled to a first access channel, an outlet coupled to a second access channel, and a plurality of trapping channels fluidically coupled at one end to the first access channel and fluidically coupled at an opposing end to the second access channel, each trapping channel has a cross-sectional dimension about 2 ?m in one direction and a cross-sectional dimension between about 0.45 and about 0.75 ?m in a second direction.Type: GrantFiled: August 9, 2013Date of Patent: November 25, 2014Assignee: The Regents of the University of CaliforniaInventors: Peter Burke, Katayoun Zand, Ted Pham, Antonio Davila, Douglas Wallace
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Patent number: 8892254Abstract: A robot controller includes queues, a storage unit, and an execution control unit. The queues are provided for respective controlled groups serving as controlled units. The storage unit stores therein instructions directed to the respective controlled groups, one at a time, from a bottom end of each of the queues. When having accepted a predetermined operation request, the execution control unit simultaneously fetches the instructions directed to the controlled groups, one for each of the controlled groups at a time, from tops of the queues, and makes all of the controlled groups simultaneously start the operations based on such instructions. If there is any controlled group to which no corresponding instruction exists, the storage unit stores therein a no-operation instruction. If the fetched instruction is the no-operation instruction, the execution control unit keeps the controlled group from operating until an instruction is fetched next time.Type: GrantFiled: February 5, 2013Date of Patent: November 18, 2014Assignee: Kabushiki Kaisha Yaskawa DenkiInventor: Takahiro Maeda
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Patent number: 8883489Abstract: Apparatus for performing an assay to detect the presence of an analyte in a test sample. A housing defines a slot for receiving a sample collector, and a capsule contains a buffer liquid, the capsule being sealed by an openable lid, and being connected to the housing such that insertion of a sample collector into the slot causes the lid to open releasing the buffer liquid into the slot. The housing further defines an incubation chamber containing or configured to receive a reagent, and an aperture permitting liquid communication between said slot and the incubation chamber. The apparatus comprises one or more test elements, a substantially liquid tight sealing member separating the incubation chamber and the test element(s), and an activation mechanism operable to open said liquid tight sealing member thereby bringing at least a portion of the or each test element into liquid communication with said incubation chamber.Type: GrantFiled: May 16, 2011Date of Patent: November 11, 2014Assignee: Concateno UK LimitedInventors: Alan Pang, Gordon Jowett, Barry Lillis, Jack Fairbank
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Patent number: 8883095Abstract: An analysis cartridge and an analysis system thereof are disclosed. The analysis cartridge comprises a cartridge body, a liquid storage box and a sealing film. The cartridge body has an accommodation portion. The liquid storage box is disposed within the accommodation portion and has a liquid storage tank and a pillar receiving hole. The sealing film covers the pillar receiving hole and seals an opening of the liquid storage tank.Type: GrantFiled: January 14, 2013Date of Patent: November 11, 2014Assignee: Lite-On Technology CorporationInventors: Cheng-Chang Lai, Fu-Chun Huang, Yuh-Jiuan Lin, Timothy Z. Liu
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Patent number: 8877517Abstract: A method for determining the amount of pore forming bacterial toxin protein in a sample is provided, the method including the steps of a) forming a membrane comprising a lipid bilayer and a receptor, b) contacting the membrane with an ion solution and the sample, c) measuring ion flow through the membrane, d) comparing the ion flow through the membrane to a standard curve, and e) determining the amount of pore forming bacterial toxin protein in the sample.Type: GrantFiled: July 10, 2014Date of Patent: November 4, 2014Inventor: John Cuppoletti
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Publication number: 20140322801Abstract: An apparatus arranged for examining particles, comprising: a cartridge having at least one microchannel, a viscoelastic fluid flowing in the microchannel, the fluid comprising a suspension of particles, thereby effecting alignment of the particles in at least one-dimensional array parallel to the fluid flow, and an optical magnifying means generating an image of the particles in the microchannel.Type: ApplicationFiled: July 14, 2014Publication date: October 30, 2014Applicants: Technion Research & Development Foundation Ltd., Pixcell Medical Technologies Ltd.Inventors: Avishay Bransky, Max Herzberg
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Patent number: 8871496Abstract: Embodiments of the present invention provide methods, microfluidic devices, and systems for the detection of an active target agent in a fluid sample. A substrate molecule is used that contains a sequence which may cleave in the presence of an active target agent. A SNAP25 sequence is described, for example, that may be cleaved in the presence of Botulinum Neurotoxin. The substrate molecule includes a reporter moiety. The substrate molecule is exposed to the sample, and resulting reaction products separated using electrophoretic separation. The elution time of the reporter moiety may be utilized to identify the presence or absence of the active target agent.Type: GrantFiled: August 20, 2009Date of Patent: October 28, 2014Assignee: Sandia CorporationInventors: Gregory J. Sommer, Anson V. Hatch, Anup K. Singh, Ying-Chih Wang
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Patent number: 8871497Abstract: A device and method for automating the handling and testing of microbiological specimens are provided. A portable specimen collection vehicle (SCV) is provided which comprises a protective housing, a specimen chamber for receiving a biospecimen sample, a plurality of culturing chambers each for receiving a portion of the biospecimen sample and each containing a different culture medium, a system of fluid ducts connecting the specimen chamber to each of the culturing chambers, and an actuator that facilitates flow of portions of the biospecimen sample from the specimen chamber through the system of fluid ducts and into each of the culturing chambers, wherein biological organisms in the biospecimen begin to grow in one or more of the culturing chambers and cultured portions of the biospecimen sample can be withdrawn selectively from the apparatus.Type: GrantFiled: January 14, 2008Date of Patent: October 28, 2014Assignee: Board of Regents of the University of NebraskaInventor: Rodney S. Markin
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Patent number: 8865427Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be provided. A receptacle housing has a plurality of receptacles. A drive is connected to the receptacle housing for moving the receptacle housing. A programmable controller can be provided to control movement of the receptacle housing. The test liquid includes at least one stimuli for the cells. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.Type: GrantFiled: August 27, 2012Date of Patent: October 21, 2014Assignees: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Camillo Ricordi, Felipe Echeverri, Over Cabrera, Per-Olof Berggren
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Patent number: 8865455Abstract: An apparatus for investigating a molecule comprising a channel provided in a substrate, a metallic moiety capable of plasmon resonance which is associated with the channel in a position suitable for the electromagnetic field produced by the metallic moiety to interact with a molecule passing therethrough, means to induce a molecule to pass through the channel, means to induce surface plasmon resonance in the metallic moiety; and means to detect interaction between the electromagnetic field produced by the metallic moiety and a molecule passing through the channel. Methods of investigating molecules are also provided.Type: GrantFiled: September 4, 2008Date of Patent: October 21, 2014Assignee: Base4 Innovation LimitedInventor: Cameron Frayling
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Patent number: 8865479Abstract: Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.Type: GrantFiled: August 16, 2010Date of Patent: October 21, 2014Assignee: President and Fellows of Harvard CollegeInventors: J. Christopher Love, Hidde L. Ploegh, Jehnna Ronan
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Publication number: 20140308690Abstract: Devices contain dried reagents that may be reconstituted and used in the calibration and quality control of sensors. Methods of producing and using the devices are also disclosed.Type: ApplicationFiled: November 19, 2012Publication date: October 16, 2014Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.Inventor: Jennifer A. Samproni
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Patent number: 8859264Abstract: A phantom device for in-vitro validation of radiation procedures under motion influence in consideration of an effective biological dose includes a phantom having a first biological detector with a first biological sample. The first biological sample includes a plurality of culturing and irradiation elements. Each of the culturing and irradiation elements are provided with a respective biological sub-sample so that the first biological detector is configured as a spatially resolving biological detector. A first motion device is configured to move the first biological detector so as to simulate a motion of a target volume.Type: GrantFiled: July 29, 2009Date of Patent: October 14, 2014Assignee: GSI Helmholtzzentrum fuer Schwerionenforschung GmbHInventors: Christoph Bert, Eike Rietzel, Alexander Gemmel
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Patent number: 8859263Abstract: The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled environment in which the cells are grown, which are maintained in a desired condition and in which cells can be examined while the environment is dynamically controlled and maintained in the desired condition. The apparatus also comprises a mechanism for determining the state of the cells. The determining mechanism is in communication with the incubating mechanism. The present invention pertains to a method for holding cells. The method comprises the steps of incubating the cells in a dynamically controlled environment which is maintained in a desired condition and in which the cells can be examined while the environment is dynamically controlled and maintained in the desired condition. Additionally, there is the step of determining the state of the cells.Type: GrantFiled: August 7, 2012Date of Patent: October 14, 2014Assignee: University of PittsburghInventors: Joel S. Greenberger, Paul A. DiMilla, Michael M. Domach, Raymond K. Houck
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Patent number: 8852529Abstract: A particle processing device includes a substrate and at least one fluidic path. The substrate is rotatable with respect to the middle region thereof. The fluidic path is provided in the substrate to extend from the middle region to a peripheral region. The fluidic path transfers a fluid having a particle from an input portion to an output portion of the fluidic pather by using a centrifugal force of the rotation of the substrate. A capturing region is formed between the input portion and the output portion of the fluidic path to have a changeable sectional shape for capturing the particle.Type: GrantFiled: August 5, 2010Date of Patent: October 7, 2014Assignee: Nexvivo Co., Ltd.Inventor: Young-Ho Cho
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Publication number: 20140296089Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: ApplicationFiled: February 18, 2014Publication date: October 2, 2014Applicant: Theranos, Inc.Inventors: Elizabeth A. Holmes, Sunny Balwani, Michael Chen, John K. Frankovich, Gary Frenzel, Surekha Gangakhedkar, Samartha Anekal, Adrit Lath, Alexander Loo, Chinmay Pangarkar, Paul Patel, Joy Roy, Timothy Smith, Daniel Young, Ian Gibbons
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Publication number: 20140295477Abstract: The present invention relates to a simple, rapid, and cost-effective test kit for detecting bacterial endotoxin in aqueous solutions, such as water for dialysis or dialysate, using an endotoxin-activatable clotting agent-based gel clot assay which can be applied at ambient temperature. The present invention also relates to a method of detecting endotoxin in aqueous solution with use of the test kit.Type: ApplicationFiled: July 25, 2012Publication date: October 2, 2014Applicant: Fresenius Medical Care Holdings, IncInventor: Michael Henrie
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Publication number: 20140295490Abstract: A device for analyzing a maternal blood sample for quantification of the percentage of fetal red blood cells present with respect to the number of maternal red blood cells includes reagents for mixing with the biological sample, a microfluidic chip, 5 fluid reservoirs, a pumping system, an image acquisition system, an image analysis system, and an electronic control board. The microfluidic channel can confine the objects of interest to a monolayer, and may trap them in an organized array for analysis. The device uses a reduced sample volume and microfluidic pumping and imaging techniques throughout. The disclosed invention holds distinct advantages over the current state of the art in fetal red blood cell quantification in a maternal blood sample by producing faster results, removing operator error, reducing 10 costs, and providing overall simplification of the testing and analysis procedure.Type: ApplicationFiled: January 30, 2014Publication date: October 2, 2014Applicant: Asta Fluidic Technologies, Inc.Inventors: Sumita Pennathur, Alejandro R. Soffici, Alexander J. Russell, Anthony T. Chobot
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Patent number: 8846414Abstract: The present invention provides for the detection of cardiac markers on a droplet actuator. An aspect provides a method of assaying a cardiac marker in a biological sample from a subject, the method including providing a droplet actuator, loading the biological sample and assay reagents on the droplet actuator, executing droplet operations to create sample droplets from the sample and reagent droplets from the reagents on the droplet actuator, and executing droplet operations using the sample droplets and reagent droplets to produce a detectable signal indicative of the quantity of the cardiac marker in the biological sample. Still other aspects are provided.Type: GrantFiled: September 29, 2009Date of Patent: September 30, 2014Assignees: Advanced Liquid Logic, Inc., Duke UniversityInventors: Ramakrishna Sista, Vamsee K. Pamula, Arjun Sudarsan, Vijay Srinivasan, Michael G. Pollack, Richard B. Fair, Allen E. Eckhardt
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Publication number: 20140287487Abstract: This disclosure is directed to a cap for obtaining a target analyte from a suspension. The cap introduces a magnetic field or a magnetic gradient to the tube to draw the target analyte bound to a particle to the cap. In one aspect, a cap includes a magnetic insert and a receiving piece. The magnetic insert includes a stopper and a magnet extending from the stopper; and, the receiving piece, which is configured to hold the magnetic insert, includes a receiving stopper and a sheath. The sheath may include imaging slides on opposite sides of the sheath. In another aspect, the cap may include a stopper and an embedded magnet. The cap may include an analysis piece on a bottom end of the stopper. In yet another aspect, the cap may include a fluid compartment and a filter at a bottom end of the stopper.Type: ApplicationFiled: March 14, 2014Publication date: September 25, 2014Applicant: RareCyte, Inc.Inventors: Daniel Campton, Jackie Lynn Stilwell, Arturo Ramirez, Jennifer Chow
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Patent number: 8841104Abstract: The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.Type: GrantFiled: April 21, 2011Date of Patent: September 23, 2014Assignee: NanoMR, Inc.Inventors: Sergey A. Dryga, Victor C. Esch, Lisa-Jo Ann Clarizia, Eddie W. Adams, Thearith H. Ung, Ravil A. Sitdikov
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Patent number: 8841118Abstract: A detection instrument determines whether a specimen container (e.g., blood culture bottle) is positive for presence of microbial agent growth therein. When the container is deemed positive it is made available (e.g, transferred or exposed to) to an automated instrument performing identification and/or characterization of the microbial agent. The identification and/or characterization instrument removes a portion of the sample from the specimen container and places it into a disposable separation and concentration device. The microbial agent is concentrated via optional selective lysis of non-microbial agent cellular material which may be present and centrifugation. A reading module reads the concentrated microbial agent using spectroscopic methods, e.g., measurements of intrinsic fluorescence. Such interrogation may occur while the microbial agent remains concentrated in the disposable device.Type: GrantFiled: May 14, 2010Date of Patent: September 23, 2014Assignee: Biomerieux, IncInventors: Ronnie J. Robinson, Mark S. Wilson, Christopher S. Ronsick, John D. Walsh, Jones M. Hyman, Thurman C. Thorpe, Bradford G. Clay
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Patent number: 8841070Abstract: The present invention relates to a device for processing an analyte and to a method of processing and/or detecting an analyte using said device.Type: GrantFiled: June 18, 2008Date of Patent: September 23, 2014Assignee: Sony Deutschland GmbHInventors: Oliver Harnack, Ingeborg Hospach, Claire Basquin, Akio Yasuda
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Patent number: 8841076Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.Type: GrantFiled: March 24, 2006Date of Patent: September 23, 2014Assignee: Theranos, Inc.Inventors: Elizabeth A. Holmes, Ian Gibbons, Timothy M. Kemp, John Howard, Shaunak Roy
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Publication number: 20140273190Abstract: A micro-channel chip comprises two gas control channels, a liquid inlet channel, a liquid outlet channel, a piston channel, and a micro pump including two micro-valves and a plurality of micro-channels. One of the gas control channels communicates with one end of the piston channel and communicates with the two micro valves and the liquid inlet channel respectively via the micro-channels. The other one of the gas control channels communicates with the two micro-valves and the liquid outlet channel respectively via the micro-channels. The other end of the piston channel communicates with one of the micro-valves via the micro-channels.Type: ApplicationFiled: October 23, 2012Publication date: September 18, 2014Inventor: Xingyue Peng
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Patent number: 8835181Abstract: A method for determining the amount of live pore forming bacterial toxin protein in a sample is provided, the method including the steps of a) forming a membrane comprising a lipid bilayer and a receptor, b) contacting the membrane with an ion solution and the sample, c) measuring ion flow through the membrane, d) comparing the ion flow through the membrane to a standard curve, and e) determining the amount of pore forming bacterial toxin protein in the sample. A kit for determining the amount of live pore forming bacterial toxin protein present in the sample is also provided.Type: GrantFiled: December 20, 2012Date of Patent: September 16, 2014Inventor: John Cuppoletti
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Patent number: 8834810Abstract: A method and apparatus for microfluidic processing by programmably manipulating a packet. A material is introduced onto a reaction surface and compartmentalized to form a packet. A position of the packet is sensed with a position sensor. A programmable manipulation force is applied to the packet at the position. The programmable manipulation force is adjustable according to packet position by a controller. The packet is programmably moved according to the programmable manipulation force along arbitrarily chosen paths.Type: GrantFiled: July 10, 2012Date of Patent: September 16, 2014Assignee: Board of Regents, The University of Texas SystemInventors: Frederick F. Becker, Peter Gascoyne, Xiaobo Wang, Jody Valentine Vykoukal, Giovanni De Gasperis
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Patent number: 8835188Abstract: Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.Type: GrantFiled: August 6, 2013Date of Patent: September 16, 2014Assignee: Presidents and Fellows of Harvard CollegeInventors: J. Christopher Love, Hidde L. Ploegh, Jehnna Ronan
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Patent number: 8835187Abstract: Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.Type: GrantFiled: August 6, 2013Date of Patent: September 16, 2014Assignee: Presidents and Fellows of Harvard CollegeInventors: J. Christopher Love, Hidde L. Ploegh, Jehnna Ronan
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Publication number: 20140256031Abstract: According to one embodiment, a semiconductor micro-analysis chip for detecting fine particles in sample liquid includes a semiconductor substrate, a flow channel formed in the semiconductor substrate and having a sample liquid inlet and sample liquid outlet at end portions thereof, and an absorber provided on at least part of the sample outlet of the flow channel to absorb the sample liquid.Type: ApplicationFiled: August 27, 2013Publication date: September 11, 2014Applicant: KABUSHIKI KAISHA TOSHIBAInventors: Kentaro KOBAYASHI, Hiroko MIKI, Akihiro KOJIMA, Hideto FURUYAMA
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Publication number: 20140256030Abstract: The present disclosure provides a biochip and methods of fabricating. The biochip includes a fluidic part and a sensing part bonded together using a polymer. The fluidic part has microfluidic channel pattern on one side and fluidic inlet and fluidic outlet on the other side that are fluidly connected to the microfluidic channel pattern. The fluidic inlet and fluidic outlet are formed by laser drilling after protecting the microfluidic channel pattern with a sacrificial protective layer. The polymer bonding is performed at low temperature without damaging patterned surface chemistry on a sensing surface of the sensing part.Type: ApplicationFiled: March 8, 2013Publication date: September 11, 2014Applicant: TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD.Inventor: TAIWAN SEMICONDUCTOR MANUFACTURING, COMPANY, LTD.
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Patent number: 8821814Abstract: A microfluidic device including a platform and a cartridge is disclosed. The platform includes a chamber containing a fluid. The reagent cartridge is mounted to the platform. and contains a solid reagent for detecting material contained in the fluid.Type: GrantFiled: June 30, 2009Date of Patent: September 2, 2014Assignee: Samsung Electronics Co., Ltd.Inventors: Yoonkyoung Cho, Dogyoon Kim, Beomseok Lee, Jongmyeon Park, Hyunmin Kim, Yangui Lee, Jong Gun Lee
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Patent number: 8822211Abstract: The invention concerns a device and a method for concentrating pathogenic germs potentially present in blood products or derivatives and for detecting said germs comprising the following steps: (a) subjecting a sample of said blood product to a blood cell aggregating treatment, (b) eliminating the aggregates formed at step (a) by passing the treated sample over a first filter allowing through the contaminating germs but not the cell aggregates, (c) selectively lyzing the residual cells of the filtrate obtained at step (b), (d) recuperating the contaminating germs by passing the lysate of step (c) over a second filter to detect the contaminating germs possibly trapped.Type: GrantFiled: June 11, 2013Date of Patent: September 2, 2014Assignee: Becton Dickinson Infusion Therapy Systems Inc.Inventors: Jean-Pierre Hermet, Isabelle Besson-Faure, Sebastien Ribault, Yann Godfrin, Anne Monnot des Angles
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Patent number: 8815572Abstract: The present invention relates to a nucleic acid extracting apparatus, and the nucleic acid extracting apparatus can include a pipe-shaped tube having an open outlet at one side thereof, and a hydrogel supporting member that is provided inside the tube and filters impurities excluding an extraction target material.Type: GrantFiled: June 22, 2009Date of Patent: August 26, 2014Assignee: Postech Academy-Industry FoundationInventors: Geun-Bae Lim, Ji-Min Kahng, Jin-Hwa Jung, Ho-Taik Kwon
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Patent number: 8815178Abstract: The invention relates to a device and method for non-invasive detection of an analyte in a fluid sample. In one embodiment, the device comprises: a collection chamber containing an absorbent hydrogel material; a fluidic channel connected to the collection chamber; a sensing chamber connected to the fluidic channel, wherein the device is comprised of a compressible housing that allows transfer of fluid collected by the collection chamber to be transferred to be extracted and withdrawn to the sensing chamber upon compression of the device, wherein the sensing chamber contains a material that specifically detects the analyte and wherein the sensing chamber is operably linked to a processor containing a potentiostat that allows detection of the analyte using electrochemical sensing.Type: GrantFiled: March 25, 2010Date of Patent: August 26, 2014Assignee: Arizona Board of Regents on Behalf of Arizona State UniversityInventors: Daniel Bishop, Jeffrey La Belle
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Patent number: 8815181Abstract: A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber (2), especially of an assay apparatus, the apparatus comprising: one or more respective storage chambers (5,6) for containing the one or more liquid reagents and arranged generally above the reaction or test chamber (2); and a plunger element (4) arranged and operable for insertion into the mouth of a selected storage chamber so as to displace a selected reagent from therewithin into the reaction or test chamber (2) generally therebelow by gravitational liquid overflow from the mouth of the chamber. The apparatus may conveniently be provided as a discrete delivery unit, with the storage chambers (5,6) pretilled with the selected reagents.Type: GrantFiled: October 23, 2012Date of Patent: August 26, 2014Assignee: The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern IrelandInventor: David James Squirrell
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Patent number: 8795967Abstract: The invention relates to compositions and methods for multiplex decoding of microsphere array sensors.Type: GrantFiled: May 13, 2013Date of Patent: August 5, 2014Assignee: Illumina, IncInventors: Mark S. Chee, John R. Stuelpnagel, Anthony W. Czarnik
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Patent number: 8795523Abstract: An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.Type: GrantFiled: March 26, 2012Date of Patent: August 5, 2014Assignee: Intel CorporationInventors: Xing Su, David J. Liu, Kai Wu, Kenneth B. Swartz, Mineo Yamakawa
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Patent number: 8785178Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A computer can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles. The test liquid includes at least one stimuli for the cells, which can be the presence, absence, or concentration of a compound in the liquid, or a physical property of the liquid such as temperature. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.Type: GrantFiled: January 12, 2007Date of Patent: July 22, 2014Assignees: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Camillo Ricordi, Felipe Echeverri, Over Cabrera, Per-Olof Berggren
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Patent number: 8778283Abstract: A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber (2), especially of an assay apparatus, the apparatus comprising: one or more respective storage chambers (5,6) for containing the one or more liquid reagents and arranged generally above the reaction or test chamber (2); and a plunger element (4) arranged and operable for insertion into the mouth of a selected storage chamber so as to displace a selected reagent from therewithin into the reaction or test chamber (2) generally therebelow by gravitational liquid overflow from the mouth of the chamber. The apparatus may conveniently be provided as a discrete delivery unit, with the storage chambers (5,6) prefilled with the selected reagents.Type: GrantFiled: January 25, 2010Date of Patent: July 15, 2014Assignee: The Secretary of State for DefenceInventor: David James Squirrell
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Patent number: 8778666Abstract: A device comprises: one or more cantilevered biomimetic cilia, and a liquid disposed among the one or more biomimetic cilia, wherein individual biomimetic cilia are at least partially submerged in the liquid, and wherein the biomimetic cilia are arranged for excitation into resonance, such as for mixing and pumping via the resonant behavior of the excited cilia.Type: GrantFiled: October 27, 2009Date of Patent: July 15, 2014Assignee: University of WashingtonInventors: Jae Chung, Santosh Devasia, James J. Riley, Kieseok Oh, Kyong Hoon Lee, Jiradech Kongthon
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Patent number: 8772049Abstract: Screening assays and methods of performing such assays are provided. In certain examples, the assays and methods may be designed to determine whether or not two or more species can associate with each other. In some examples, the assays and methods may be used to determine if a known antigen binds to an unknown monoclonal antibody.Type: GrantFiled: August 6, 2013Date of Patent: July 8, 2014Assignee: President and Fellows of Harvard CollegeInventors: J. Christopher Love, Hidde L. Ploegh, Jehnna Ronan
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Patent number: 8759080Abstract: A biological growth plate scanner includes a multi-color illumination system that illuminates a biological growth plate with different illumination colors. A monochromatic image capture device captures images of the biological growth plate during illumination of the growth plate with each of the illumination colors. A processor combines the images to form a composite multi-color image, and/or individual components of the composite image, and analyzes the composite image to produce an analytical result such as a colony count or a presence/absence result. The biological growth plate scanner may include both front and back illumination components. The back illumination component may include a diffuser element disposed under the biological growth plate. The diffuser element receives light from one or more laterally disposed illumination sources, and distributes the light to illuminate a back side of the biological growth plate.Type: GrantFiled: February 2, 2009Date of Patent: June 24, 2014Assignee: 3M Innovative Properties CompanyInventors: Josef A. Graessle, Stephen B. Schenk, Michael C. Lea
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Publication number: 20140170671Abstract: An apparatus including a plurality of wells for conducting analysis of three-dimensional cell samples (e.g., tissue samples) and methods for experimenting with a three-dimensional sample. A removable insert for use with the apparatus enables plunger-driven perfusion of the three-dimensional sample.Type: ApplicationFiled: November 13, 2013Publication date: June 19, 2014Applicant: Seahorse BioscienceInventors: Paul McGarr, Andy C. Neilson, Jay S. Teich
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Publication number: 20140170636Abstract: A method and an automated system for testing liquid samples comprising a reaction vessel transferring device are presented. A first analytical unit for running a first diagnostic test comprises a rotatable first vessel holder detachably holding reaction vessels. A second analytical unit for running a second diagnostic test comprises a stationary linear second vessel holder detachably holding reaction vessels. The transferring device comprises a gripper for gripping a reaction vessel and transfers reaction vessels from the first vessel holder to the second vessel holder and/or vice versa. The device is translatable parallel to the second vessel holder and the gripper moves along a curved path between a picking position and a reaction vessel seat of the second vessel holder.Type: ApplicationFiled: December 11, 2013Publication date: June 19, 2014Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Marco Bucher, Gottlieb Schacher
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Patent number: 8753894Abstract: An integrated microelectronic sensor is provided in a disposable flow membrane sensing device. The integrated sensors detect electromagnetic effect labels in flow detection zones above the sensor in the membrane. The labels are small particles that give off a detectable electromagnetic signal. They are commonly used for isolating and quantifying biochemical targets of interest. The sensors are fabricated using planar integrated circuit technologies. Sensors can detect labels of several types including magnetic, electric, and photonic. These types all have in common the fact that the sensor detects the label at a distance. Magnetoresistive sensors for detecting magnetic labels, and photodiodes for detecting photonic labels are described. A system for using the sensors is described. There are disposable cartridges with a backing that supports the sensors and membrane is described. The integrated sensor in the cartridge is designed to be discarded after use. Also, label excitation sources are provided.Type: GrantFiled: February 1, 2008Date of Patent: June 17, 2014Assignee: Diagnostic Biosensors, LLCInventor: Mark Christopher Tondra
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Patent number: 8753890Abstract: An apparatus and method for analyzing a biological fluid sample is provided. The method includes the steps of: a) providing an analysis cartridge having a channel and an analysis chamber, wherein the channel is in fluid communication with the analysis chamber and includes at least one hydrophobic interior wall surface; b) admixing one or more anti-adsorption agents with fluid sample disposed within the channel, wherein the anti-adsorption agents are operable to inhibit adsorption of fluid sample onto the interior wall surface of the channel; c) moving the fluid sample into the analysis chamber; and d) analyzing the sample within the analysis chamber.Type: GrantFiled: December 8, 2011Date of Patent: June 17, 2014Assignee: Abbott Point of Care, Inc.Inventors: Niten V. Lalpuria, Darryn W. Unfricht, Igor Nikonorov, Benjamin Ports, Douglas R. Olson