Bacteria Or Actinomycetales Patents (Class 435/7.32)
  • Patent number: 10830769
    Abstract: Definitive diagnosis and early start of treatment cannot be made for tuberculosis since conventional methods for detecting a Mycobacterium tuberculosis complex require a long time plus enormous labor and expense. Because detection is difficult to perform directly from a biological sample, if the biological sample contains no or a very small amount of the Mycobacterium tuberculosis complex-specific secretory protein, there is a risk infection with the Mycobacterium tuberculosis complex will be missed.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: November 10, 2020
    Assignee: TAUNS CO., LTD
    Inventors: Urao Nonaka, Toshiyuki Kitagawa
  • Patent number: 10788489
    Abstract: The present invention relates to a method for the detection of a protein including a histidine-tag using immunochromatography. The detection method of the present invention uses immunochromatography using the polymer particle fixed with the histidine-tag, wherein a histidine-tag specific antibody alone is used to detect a histidine-tag conjugated protein (recombinant protein) quickly without using a target protein specific antibody. This method is also efficient in detecting and quantifying the histidine-tagged protein included in the sample without using an additional apparatus but quickly and accurately.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: September 29, 2020
    Assignee: Daegu Gyeongbuk Institute of Science and Technology
    Inventors: Eun Joo Kim, Won Bae Jeon, Sung Jun Lee, Se Geun Lee, Eun Sook Choi
  • Patent number: 10604784
    Abstract: A system and method for antibiotic susceptibility testing efficiently determines whether bacteria are alive or have been killed by antibiotic treatment. The antibiotic susceptibility testing device includes at least one reservoir into which a bacteria solution is introduced and a microfluidic channel connected to the reservoir, wherein the cross-sectional size of the microfluidic channel is selected to be comparable to the size of the bacterium to be tested. Furthermore, the electrical resistance or voltage signal across the microchannel is monitored as bacteria swim into and out of the channel. Alternatively, a small population of bacteria can be immobilized in the microchannel. The resistance or voltage signal fluctuates when the bacteria are alive and moving in and out of the channel or wiggling on the microchannel walls. If the bacteria are dead, they have limited motility and the signal fluctuations are significantly smaller.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: March 31, 2020
    Assignee: Trustees of Boston University
    Inventors: Kamil Ekinci, Le Li, Chuanhua Duan, Vural Kara, Deborah Stearns-Kurosawa
  • Patent number: 10578612
    Abstract: The present disclosure relates generally to the field of immunological-based diagnostic assays. Particularly, a method is contemplated herein for measuring cell-mediated immune response reactivity. The present disclosure further provides a method to reduce incidence of non-specific immune response reactivity in a cell-mediated immune response-based assay, comprising contacting a sample with a basic peptide structure capable of binding to lipopolysaccharides, such as polymyxin B or a sushi peptide.
    Type: Grant
    Filed: May 23, 2011
    Date of Patent: March 3, 2020
    Assignee: Cellestis International Pty Ltd.
    Inventors: Anthony J. Radford, Emily Manktelow, Jeff Boyle, Jenny Louise Howard
  • Patent number: 10522025
    Abstract: Methods, systems, and apparatus to monitor component status in a bioprocessing environment are disclosed and described. Certain examples provide a sensor device for a disposable bioprocessing component. The example sensor device includes a first portion affixed to the component, the first portion configured to provide an identifier associated with the component. The example sensor device also includes a second portion configured to provide a status indication based on a state of the component. The example sensor device is configured to transmit the identifier and status indication to a control computer associated with a bioprocessing platform including the component.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: December 31, 2019
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Radislav A. Potyrailo, Klaus Gebauer, Kajsa Stridsberg-Friden, Timothy A. Wortley
  • Patent number: 10504711
    Abstract: A number of standard methods exist for normalizing MALDI-TOF data, but they are not able to compensate adequately for the observed technical variability. The invention creates an improved normalization method for MALDI-TOF mass spectrometry data. This is achieved by an intensity profile normalization, where, by way of example, 1) Firstly, an intensity profile is formed for each individual spectrum, and this intensity profile describes the statistical distribution of the intensity values within different mass ranges; 2) Then an average reference profile is formed for an ensemble of spectra; 3) Finally, the individual spectra are transformed in such a way that their intensity profiles correspond to the reference profile.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: December 10, 2019
    Inventors: Tobias Boskamp, Delf Lachmund
  • Patent number: 10487331
    Abstract: Disclosed herein are aptamers that bind specifically to the surface proteins of periodontal pathogens. Disclosed also herein are kits and methods for detecting bacteria associated with periodontal disease by using the present aptamers to analyze a sample taken from the oral cavity of a patient.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: November 26, 2019
    Assignee: NATIONAL CHENG KUNG UNIVERSITY
    Inventors: Ping-Ching Wu, Dar-Bin Shieh, Fong-Yu Cheng, Yuh-Ling Chen
  • Patent number: 10376570
    Abstract: Anaplasma phagocytophilum surface proteins Asp14 and OmpA and homologous genes from Anaplasmatacaea family members are used in compositions suitable for vaccines to treat or prevent infections caused by tick-born bacteria of the Anaplasmatacaea family. Asp14 and/or OmpA proteins or peptide fragments may be used in combination with other Anaplasmatacaea surface proteins to elicit an immune response. Furthermore, antibodies to Asp14 and/or OmpA proteins can be used in diagnostic methods to determine whether an individual has contracted an Anaplasmatacaea infection. Because of the conserved invasin domains in the surface proteins, a wide range of Anaplasmatacaea infections may be diagnosed, treated or prevented using compositions of the invention.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: August 13, 2019
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventor: Jason A. Carlyon
  • Patent number: 10346653
    Abstract: A cartridge, an analysis system, a method and a computer program product for testing a sample, such as, environmental, food or biological sample, wherein the cartridge has two memory means that are different and/or can be read out by different methods and which correspond to the cartridge or to the batch thereof.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: July 9, 2019
    Assignee: BOEHRINGER INGELHEIM VETMEDICA GMBH
    Inventors: Heinz Schoeder, Axel Niemeyer, Kai Wuerz
  • Patent number: 10316347
    Abstract: In situ optical analysis of bacterial endospores can be inhibited when the endospores are present within an optically active carrier medium. To help isolate the endospores from the carrier medium, in some examples, the carrier medium is passed through a hydrophobic material that captures the endospores via hydrophobic attraction. Subsequently, a germination fluid and lanthanide source, such as terbium, can be added to the bacterial endospores captured on the hydrophobic material to form a lanthanide-dipicolinic acid complex in the germination fluid. The germination fluid can then be optically analyzed by measuring the fluorometric response of the lanthanide-dipicolinic acid complex to determine a concentration of the bacterial endospores in the carrier medium.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: June 11, 2019
    Assignee: Ecolab USA Inc.
    Inventors: Anthony Wayne Erickson, Elaine Patricia Black, Nathan Richard Ortmann, Rodney H. Banks
  • Patent number: 10302642
    Abstract: Methods and systems for measuring the concentration of LAL-reactive substances in fluid samples is provided. They include contacting an aqueous sample with a detection reagent to form a prepared sample. A physical property of the prepared sample may be measured to obtain at least one sample measurement characteristic of the prepared sample. Curve fitting may then be used to forecast a concentration of the LAL-reactive substance the aqueous sample will have at a specified time in the future based on the sample measurement and a correlation developed between at least one standard measurement of a physical quality of a solution with a known concentration of a LAL-reactive substance therein. The quality of the sample measurement may be validated using historical data and/or the standard measurement.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: May 28, 2019
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Paul Charles Melanson, Vidyasankar Sundaresan, Richard Douglas Godec, Shouquan Deng
  • Patent number: 10167495
    Abstract: A microbe quantifying apparatus includes: a filtering mechanism that filters microbes contained in a fluid sample with a filter; a quantifying mechanism that quantifies the microbes with a specified biological material contained in the microbes on the filter as an index; and an anti-drying mechanism that prevents drying of the microbes on the filter.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: January 1, 2019
    Assignee: HITACHI, LTD.
    Inventors: Shuichi Mori, Noe Miyashita, Yuta Nakatsuka
  • Patent number: 10145833
    Abstract: A method of analysis of a hydrocarbon fuel for the presence of a micro-organism comprises contacting a fuel sample with an aqueous diluent and with an antibody reactive with the micro-organism, or reactive with a metabolite or breakdown product produced by the micro-organism, to detect the presence or absence of the micro-organism.
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: December 4, 2018
    Assignee: CONIDIA BIOSCIENCE LIMITED
    Inventor: Joan Kelley
  • Patent number: 10089850
    Abstract: Methods, systems, and apparatus to monitor component status in a bioprocessing environment are disclosed and described. Certain examples provide a sensor device for a disposable bioprocessing component. The example sensor device includes a first portion affixed to the component, the first portion configured to provide an identifier associated with the component. The example sensor device also includes a second portion configured to provide a status indication based on a state of the component. The example sensor device is configured to transmit the identifier and status indication to a control computer associated with a bioprocessing platform including the component.
    Type: Grant
    Filed: January 16, 2017
    Date of Patent: October 2, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Radislav A. Potyrailo, Klaus Gebauer, Kajsa Stridsberg-Friden, Timothy A. Wortley
  • Patent number: 10090113
    Abstract: Presented herein is a voltaic cell containing light harvesting antennae or other biologically-based electron generating structures optionally in a microbial population, an electron siphon population having electron conductive properties with individual siphons configured to accept electrons from the light harvesting antennae and transport the electrons to a current collector, an optional light directing system (e.g., a mirror), and a regulator having sensing and regulatory feedback properties for the conversion of photobiochemical energy and biochemical energy to electricity. Also presented herein is a voltaic cell having electricity-generating abilities in the absence of light. Also presented herein is the use of the voltaic cell in a solar panel.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: October 2, 2018
    Assignee: Bugsy Solar LLC
    Inventor: Emily A. Stein
  • Patent number: 10046040
    Abstract: The invention relates to a multivalent Clostridium difficile vaccine comprising a Salmonella Typhi live vector comprising the cell binding domain of TcdA toxin (CBD/A) of Clostridium difficile or an antigenic fragment thereof and the cell binding domain of TcdB toxin (CBD/B) of Clostridium difficile or an antigenic fragment thereof and optionally the cell-binding subunit component (CdtB) of binary toxin of Clostridium difficile or an antigenic fragment thereof. The invention further provides methods of inducing an immune response and methods of preventing recurrence of C. difficile infections in subjects.
    Type: Grant
    Filed: November 16, 2010
    Date of Patent: August 14, 2018
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventor: James E. Galen
  • Patent number: 10039815
    Abstract: Anaplasma phagocytophilum surface proteins Asp14 and OmpA and homologous genes from Anaplasmatacaea family members are used in compositions suitable for vaccines to treat or prevent infections caused by tick-born bacteria of the Anaplasmatacaea family. Asp14 and/or OmpA proteins or peptide fragments may be used in combination with other Anaplasmatacaea surface proteins to elicit an immune response. Furthermore, antibodies to Asp14 and/or OmpA proteins can be used in diagnostic methods to determine whether an individual has contracted an Anaplasmatacaea infection. Because of the conserved invasin domains in the surface proteins, a wide range of Anaplasmatacaea infections may be diagnosed, treated or prevented using compositions of the invention.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: August 7, 2018
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventor: Jason A. Carlyon
  • Patent number: 9945851
    Abstract: Anaplasma Marginale surface protein OmpA and homologous genes from Anaplasmatacaea family members are used in compositions suitable for vaccines to treat or prevent infections caused by tick-born bacteria of the Anaplasmatacaea family. OmpA proteins or peptide fragments may be used in combination with other Anaplasmatacaea surface proteins to elicit an immune response. Furthermore, antibodies to OmpA proteins can be used in diagnostic methods to determine whether an individual has contracted an Anaplasmatacaea infection.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: April 17, 2018
    Assignee: Virginia Commonwealth University
    Inventor: Jason A. Carlyon
  • Patent number: 9915656
    Abstract: A hand-held measuring instrument is used for detecting hidden mold damage in interior spaces. The measuring instrument includes at least one collection unit configured to intake at least of one interior space sample, at least one buffer unit, at least one immunological test unit, an evaluation unit and a control panel. The at least one buffer unit has a first compartment and a second compartment.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: March 13, 2018
    Assignee: Robert Bosch GmbH
    Inventor: Katrin Luckert
  • Patent number: 9878020
    Abstract: The present disclosure describes compositions for intestinal delivery of enzyme formulations and methods of treating health problems with these formulations. More specifically, the enzyme formulations include at least one histaminase and various methods of treatment of physical conditions, such as inflammation, allergy, histamine intolerance, and intestinal cancer.
    Type: Grant
    Filed: April 5, 2012
    Date of Patent: January 30, 2018
    Assignee: Histapharm Inc.
    Inventors: Mircea-Alexandru Mateescu, Carmen Calinescu, Pompilia Ispas-Szabo, Bruno Mondovi, Rodolfo Federico
  • Patent number: 9863006
    Abstract: The present invention discloses methods, kits-of-parts, and devices for the selective lysis of eukaryotic cells in a sample comprising micro-organisms such as bacteria unicellular fungi. The selective lysis is obtained by incubating the sample in an ionic surfactant under alkaline conditions.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: January 9, 2018
    Assignee: Biocartis NV
    Inventors: Irene Dobbelaer, Sieglinde Neerken, Paul Van De Wiel, Bart Van Meerbergen, Roel Penterman
  • Patent number: 9856283
    Abstract: There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: January 2, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Stefan Oscarson, John Vincent Fahy, Shaopeng Yuan, Stephen Carrington
  • Patent number: 9850516
    Abstract: A system and method of detecting spores includes a light source configured to emit a light pulse within a first wavelength range, and a light sensor configured to detect a resulting phosphorescence emitted from one or more desiccated spores phosphorescing within a second wavelength range in a vicinity of the light pulse. The spore detector also includes circuitry configured to trigger emission of the light pulse and record the emitted phosphorescence at a pre-determined time after the light pulse.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: December 26, 2017
    Inventor: John Arthur Wood
  • Patent number: 9841424
    Abstract: The present invention relates to methods and kits for detecting active tuberculosis infection in a subject using serological techniques and a first agent capable of binding an IgG, IgA and/or IgM directed to the first protein present in or on a Mycobacterium tuberculosis membrane vesicle or a Bacillus Calmette-Guerin (BCG) membrane vesicle. Also provided are methods of treating a subject with an active tuberculosis disease.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: December 12, 2017
    Assignee: Albert Einstein College of Medicine, Inc.
    Inventors: Jacqueline Michele Achkar, Arturo Casadevall, Rafael Prados-Rosales, Anke Ziegenbalg
  • Patent number: 9839682
    Abstract: The present invention relates to compositions comprising EbpA and methods of use thereof. Specifically, methods useful in the treatment and prevention of EbpA-associated infections.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: December 12, 2017
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Scott J. Hultgren, Michael G. Caparon, Jerome Pinkner, Ana L. Flores-Mireles
  • Patent number: 9814768
    Abstract: The present invention concerns gp19 immunoreactive compositions for E. canis and compositions related thereto, including vaccines, antibodies, polypeptides, peptides, and polynucleotides. In particular, epitopes for E. canis gp19 are disclosed.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: November 14, 2017
    Assignee: Research Development Foundation
    Inventors: Jere W. McBride, Christopher Kuyler Doyle
  • Patent number: 9809809
    Abstract: The present invention relates to the pharmaceutical field. Specifically, it contemplates a polynucleotide encoding a neurotoxin polypeptide exhibiting a reduced duration of the biological effect in a subject, wherein said polypeptide comprises at least one E3 ligase recognition motif in the light chain, wherein said E3 ligase recognition motif is preferably a binding motif for the E3 ligase MDM2. The invention further pertains to polypeptides encoded by the polynucleotide of the invention as well as polypeptides comprising one or more amino acid substitutions. Further encompassed by the present invention are vectors and host cells comprising the said polynucleotide, polypeptides encoded thereby and antibodies specifically binding to the polypeptides. Moreover, the invention relates to medicaments comprising said polynucleotides and polypeptides, as well as specific therapeutic applications thereof. Furthermore, the present invention contemplates methods for the manufacture of the polypeptides and medicaments.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: November 7, 2017
    Assignee: MERZ PHARMA GmbH & CO. KGaA
    Inventors: Michael Schmidt, Jurgen Frevert, Fred Hofmann, Gerhard Groer
  • Patent number: 9759732
    Abstract: Methods and kits for detecting antibodies (e.g., anti-drug antibodies). Such methods and kits permit the detection of, for example, anti-drug antibodies in human body fluids, such as blood, plasma and serum.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: September 12, 2017
    Assignee: GENZYME CORPORATION
    Inventors: Ryan Grabert, Susan Richards, Valerie Theobald, Yuanxin Xu, Jad Zoghbi
  • Patent number: 9725770
    Abstract: Herein are described 1058 different bacterial taxa that were unique to either human, grazing mammal, or bird fecal wastes. These identified taxa can serve as specific identifier taxa for these sources in environmental waters. Two field tests in marine waters demonstrate the capacity of phylogenetic microarray analysis to track multiple sources with one test.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: August 8, 2017
    Assignee: The Regents of the University of California
    Inventors: Gary L. Andersen, Eric A. Dubinsky
  • Patent number: 9726667
    Abstract: Point of care methods to detect the probability or status of tuberculosis infection in individuals by determining presence or absence of one or more peptide of SEQ ID NOS:1-22 in a biological fluid of a subject are described. These methods may be assays based on affinity reagents specifically reactive with these peptides.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: August 8, 2017
    Assignee: INSTITUTE FOR SYSTEMS BIOLOGY
    Inventors: Robert L. Moritz, Mark Sartain, Zdenek Spacil, Ulrike Kusebauch, David Campbell
  • Patent number: 9605032
    Abstract: The present invention concerns gp19 immunoreactive compositions for E. canis and compositions related thereto, including vaccines, antibodies, polypeptides, peptides, and polynucleotides. In particular, epitopes for E. canis gp19 are disclosed.
    Type: Grant
    Filed: August 7, 2007
    Date of Patent: March 28, 2017
    Assignee: Research Development Foundation
    Inventors: Jere W. McBride, Christopher K. Doyle
  • Patent number: 9571904
    Abstract: Methods, systems, and apparatus to monitor component status in a bioprocessing environment are disclosed and described. Certain examples provide a sensor device for a disposable bioprocessing component. The example sensor device includes a first portion affixed to the component, the first portion configured to provide an identifier associated with the component. The example sensor device also includes a second portion configured to provide a status indication based on a state of the component. The example sensor device is configured to transmit the identifier and status indication to a control computer associated with a bioproces sing platform including the component.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: February 14, 2017
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Radislav A. Potyrailo, Klaus Gebauer, Kajsa Stridsberg-Friden, Timothy A. Wortley
  • Patent number: 9347943
    Abstract: Chimera proteins including: (i) at least one sequence of a DbpA protein of a Borrelia species selected from B. afzelii, B. burgdorferi sensu stricto and B. garinii, and (ii) at least one sequence of an OspC protein of a Borrelia species selected from B. afzelii, B. burgdorferi sensu stricto and B. garinii. Also, a method and a kit for the in vitro diagnosis of Lyme borreliosis using said proteins.
    Type: Grant
    Filed: August 26, 2010
    Date of Patent: May 24, 2016
    Assignee: BIOMERIEUX
    Inventors: Lionel Levet, Odile Mejan-Letourneur
  • Patent number: 9291629
    Abstract: Methods of detecting a first species' Ig-CTF in a biological sample comprising exposing the biological sample to a first antibody of a second species that preferentially binds the first species' Ig-CTF or an antigen binding fragment of the antibody, forming a mixture, exposing the mixture to a second antibody or antigen-binding fragment of a third species that preferentially binds the first species' Ig, and detecting the Ig-CTF in the biological sample.
    Type: Grant
    Filed: February 22, 2012
    Date of Patent: March 22, 2016
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Michael Pugia
  • Patent number: 9285373
    Abstract: The present invention relates to a method for examining a person having symptoms and/or biomarkers indicating an autoimmune disease for the presence of atrophic gastritis. The biomarker combination, which diagnoses atrophic gastritis, acts also as a part of a biomarker panel that helps diagnosis and assessment of autoimmune disease as well. The invention relates also to products used in these methods.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: March 15, 2016
    Assignee: BIOHIT OYJ
    Inventor: Osmo Suovaniemi
  • Patent number: 9274121
    Abstract: A composition includes an artificial construct having (a) a reporter-containing portion chemically coupled to (b) a cleavage site. The cleavage site interacts with an investigational substance in a manner that cleaves the reporter-containing portion from a remainder of the construct. The cleaved portion is destroyed or otherwise degraded by the local environment, and presence of an investigational substance is evidenced by reduction in signal from the reporter. The investigational substance is preferably a Botulinum toxin (BoTN), and the cleavage sequence is all or part of a SNARE protein. The cleavable reporter-containing portion is preferably Yellow Fluorescent Protein (YFP), Citrine, Venus, or a YPet protein.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: March 1, 2016
    Assignee: BIOMADISON, INC.
    Inventors: Dhammika Atapattu, Ward C. Tucker
  • Patent number: 9181575
    Abstract: A method for detecting and enumerating viable microorganisms in a sample suspected of containing said microorganisms (1) contacting said microorganisms of said sample with at least one repair compound and a growth medium, and (2) incubating the product of steps (1), and (3) detecting and quantifying said viable microorganisms, in which the microorganisms are of the species Legionella pneumophila, and in which the repair compound directly or indirectly causes an effect on the metabolism to reduce the oxidative stress of the microorganism. The invention also includes a kit for more accurately detecting and enumerating viable microorganisms of the species Legionella pneumophila in a sample suspected of containing said microorganisms.
    Type: Grant
    Filed: March 20, 2009
    Date of Patent: November 10, 2015
    Assignees: BASF SE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Yannick Fovet, Sam Dukan, Adrien Ducret
  • Patent number: 9169319
    Abstract: Methods and compositions for the treatment of biofilms and/or the inhibition of biofilm formation. In one embodiment, a biofilm is treated and/or biofilm formation is inhibited by a method comprising contacting a biofilm or a surface with a bifunctional ligand comprising a quorum-sensing-peptide-binding region and a protease-binding region, whereby the biofilm is treated and/or biofilm formation on the surface is inhibited.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: October 27, 2015
    Assignee: KCI Licensing, Inc.
    Inventors: Rodolfo Alarcon, Amy K. McNulty
  • Patent number: 9156893
    Abstract: The present invention provides novel antimicrobial bacteria strains and uses thereof to prepare novel antimicrobial agents. Also provided are the novel antimicrobial agents.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: October 13, 2015
    Assignee: Fraunhofer USA Inc.
    Inventors: Vadim Mett, Vidadi Yusibov
  • Patent number: 9145455
    Abstract: High affinity antibodies for binding epitopes of BoNT/B and hybridomas that produce such antibodies are described. The antibodies may be used in a kit for detecting BoNT/B in a sample.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: September 29, 2015
    Assignee: The United States of America, as represented by The Secretary of Agriculture
    Inventors: Larry H. Stanker, Miles C. Scotcher, Luisa W. Cheng, Robert M. Hnasko, Jeffery A. McGarvey
  • Publication number: 20150148255
    Abstract: This disclosure is directed to an apparatus, system and method for retrieving a target material from a suspension. A system includes a plurality of processing vessels and a collector. The collector funnels portions of the target material from the suspension through a cannula and into the processing vessels. Sequential density fractionation is the division of a sample into fractions or of a fraction of a sample into sub-fractions by a step-wise or sequential process, such that each step or sequence results in the collection or separation of a different fraction or sub-fraction from the preceding and successive steps or sequences. In other words, sequential density fractionation provides individual sub-populations of a population or individual sub-sub-populations of a sub-population of a population through a series of steps.
    Type: Application
    Filed: January 30, 2015
    Publication date: May 28, 2015
    Applicant: RareCyte, Inc.
    Inventors: Lance U'ren, Daniel Campton, Joshua Nordberg, Steve Quarre, Jonathan Lundt
  • Publication number: 20150147332
    Abstract: An isolated protein or peptide selected from the group consisting of Bordetella colonization factor A (BcfA) protein and antigenic fragments thereof is described, along with an isolated nucleic acid encoding the same, antibodies that bind to the same, methods of producing an immune response in a mammalian subject in need thereof by administering the proteins, peptides or antibodies, and pharmaceutical compositions comprising the same.
    Type: Application
    Filed: September 26, 2014
    Publication date: May 28, 2015
    Inventors: Rajendar K. Deora, Meenu Mishra, Neelima Sukumar
  • Patent number: 9040250
    Abstract: A composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6. A method of administering to an immunosuppressed patient or a patient diagnosed with sepsis or septic shock a composition having a proanthocyanidin. A method of administering to a patient diagnosed with a gram negative bacterial infection a composition having proanthocyanidin compounds having an average degree of polymerization of at least about 6.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: May 26, 2015
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: James B Delehanty, Brandy J White, Baochuan Lin, Frances S Ligler
  • Publication number: 20150132740
    Abstract: A concentration agent for microorganisms is provided that contains both lanthanum and carbonate. Additionally, articles that include the concentration agent and methods of concentrating a microorganism using the concentration agent are provided.
    Type: Application
    Filed: May 23, 2013
    Publication date: May 14, 2015
    Inventors: Manjiri T. Kshirsagar, Evan Koon Lun Yuuji Hajime, Andrew W. Rabins
  • Publication number: 20150125883
    Abstract: The present invention encompasses methods of isolating, identifying, and characterizing microorganisms present in a microbial community occupying a body habitat/surface of a healthy or unhealthy human or animal. More particularly, the invention relates to methods of isolating and identifying viable microorganisms that interact with a host's immune system.
    Type: Application
    Filed: April 30, 2013
    Publication date: May 7, 2015
    Inventors: Jeffrey I. Gordon, Andrew Kau, Chyi-Song Hsieu, Sindhuja Rao, Nathan P. Mcnulty
  • Patent number: 9023606
    Abstract: The present invention relates to the field of Serum Bactericidal Activity (SBA) assays for Gram negative bacteria, in particular N. meningitidis. The SBA assay is the most important method for measuring functional activity of serum antibodies against meningococcus. In order to determine whether a subject or a population is seropositive against invasive meningococcus the SBA test should ideally be both sensitive and specific. The inventors have found the standard N. meningitidis serotype A and W SBAs can be significantly improved in this regard.
    Type: Grant
    Filed: March 14, 2011
    Date of Patent: May 5, 2015
    Assignee: GlaxoSmithKline Biologicals S.A.
    Inventors: Isabel De Vleeschauwer, Nathalie Durant, Jan Poolman, Vincent Weynants
  • Publication number: 20150118675
    Abstract: The present invention provides an immunochromatography detection method capable of suppressing non-specific reactions. The present invention relates to an immunochromatography detection method including: a step of adding an analyte dilution solution containing an analyte to a chromatography medium; a step of recognizing a detection target by a labeling substance modified with gold nanoparticles, which is dry-retained at a labeling substance retaining part; a step of developing a composite of the labeling substance and the detection target as a mobile phase; and a step of detecting the detection target in the developed mobile phase at a judgment part, wherein the labeling substance is protected with a polyalkylene glycol having one or more mercapto groups and/or a derivative thereof and then dry-retained together with arginine and casein at the labeling substance retaining part.
    Type: Application
    Filed: March 13, 2013
    Publication date: April 30, 2015
    Inventor: Daisuke Ito
  • Publication number: 20150111784
    Abstract: In some cases, the described systems and methods include obtaining a cell sample containing multiple antibody-producing cells. In such cases, the cells can be tagged with a cross-linking reagent having a first portion configured to bind to a marker on the antibody-producing cells and a second portion configured to bind to an antigen of interest. In some instances, the tagged antibody-producing cells are exposed to the antigen of interest such that the antigen becomes bound to the cells. In some such instances, the antibody-producing cells are also allowed to produce an antibody, such that a portion of the antibody-producing cells produce an antigen-specific antibody that binds to the antigen of interest. To identify cells that produce the antigen-specific antibody, the tagged cells can be exposed to a labeled secondary antibody that is configured to bind to the antigen-specific antibody. Other implementations are also described.
    Type: Application
    Filed: December 26, 2014
    Publication date: April 23, 2015
    Inventor: Kevin T. Chapman
  • Publication number: 20150111201
    Abstract: A portable rapid diagnostic test reader system includes a mobile phone having a camera and one or more processors contained within the mobile phone and a modular housing configured to mount to the mobile phone. The modular housing including a receptacle configured to receive a sample tray holding a rapid diagnostic test. At least one illumination source is disposed in the modular housing and located on one side of the rapid diagnostic test. An optical demagnifier is disposed in the modular housing interposed between the rapid diagnostic test and the mobile phone camera.
    Type: Application
    Filed: October 31, 2014
    Publication date: April 23, 2015
    Inventors: Aydogan Ozcan, Onur Mudanyali, Stoyan Dimitrov, Uzair Sikora, Swati Padmanabhan, Isa Navrus
  • Patent number: 9012152
    Abstract: Isolated peptides comprising no more than ten amino acids and having anti-bacterial properties are disclosed. In one embodiment the peptides have a consensus amino acid sequence X1X2X3X4X5, wherein X1 and X5 comprise polar amino acids. In another embodiment, the peptides have a consensus amino acid sequence X1X2X3X4X5, wherein X2 and X4 are asparagine (N) residues and X3 is tryptophan (W). Compositions comprising same are also disclosed and uses thereof.
    Type: Grant
    Filed: January 8, 2008
    Date of Patent: April 21, 2015
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Hanna Engelberg-Kulka, Ilana Kolodkin-Gal