Amine And Quaternary Ammonium Patents (Class 436/111)
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Publication number: 20020120406Abstract: Diagnostic method, based on the amounts of biogenic amines that are contained in a body fluid or other sample. A number of measured parameters related to the desired diagnostic information are derived from the amounts. For each diagnostic information desired, an input consisting of the identification of the diagnostic information is provided. The input is compared to the measured parameters and a diagnostic response is derived from the comparison. The measured parameters may be derived from the amounts of the biogenic amines according to a program stored in a memory. The detection of the less volatile amines and their separation from the more volatile ones may advantageously be enhanced by successively adding a base and an acid, in either possible succession, to the sample and analyzing the vapors emitted by the sample under heating.Type: ApplicationFiled: February 20, 2002Publication date: August 29, 2002Inventors: Avraham Lorber, Zeev Karpas
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Patent number: 6432717Abstract: A test reagent composition and device are provided for determination of cyanuric acid in water, said composition including melamine, a pH indicator that changes color due to the reaction of melamine with the cyanuric acid in the water, and a stabilizing compound capable of forming hydrogen bonds with the melamine but which does not compete with the cyanuric acid.Type: GrantFiled: August 1, 2000Date of Patent: August 13, 2002Assignee: Environmental Tests Systems, Inc.Inventor: Sellapperumage Rupasiri Fernando
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Publication number: 20020106807Abstract: It is discovered that a composition comprising at least one amine and at least one stabilizer may be useful in detecting the presence of an adulterant in a urine sample. Such adulterant includes an oxidizing agent.Type: ApplicationFiled: June 6, 2001Publication date: August 8, 2002Applicant: Quest Diagnostics, Inc.Inventors: John Novinski, Barry Sample, Richard L. Hilderbrand, Susan Mills, Victoria Johnson
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Patent number: 6426190Abstract: A process and a kit are provided for detecting differences in two or more samples of protein, including proteins bearing post-translational modifications and peptides. Proteins are prepared, for example, from each of a different group of cell samples or body fluid samples to be compared. Each protein extract is labeled with a different one of a luminescent dye from a matched set of dyes. The matched dyes have generally the same ionic and pH characteristics but emit light at different wavelengths to exhibit a different color upon luminescence detection. The labeled protein extracts are mixed together and separated together by electrophoresis or a chromatographic method. The separation is observed to detect proteins unique to one sample or present in a greater ratio in one sample than in the other. Those unique or excess proteins will fluoresce the color of one of the dyes used. Proteins common to each sample migrate together and fluoresce the same.Type: GrantFiled: August 9, 1999Date of Patent: July 30, 2002Assignee: Carnegie Mellon UniversityInventors: Jonathan Minden, Alan Waggoner, Susan Janet Fowler
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Publication number: 20020090735Abstract: A detection system for detecting base contamination at low concentrations in gas, for instance to protect a sensitive process, characterized in that the detection system is constructed to examine multiple amines in gas to produce a reading stoichiometrically related to the proton bonding characteristic of the multiple amines present, the detection system comprising at least two channels through which a gas to be examined passes, an amines remover located in one of the channels, at least one thermal/catalytic converter which discharges NO for each channel, and at least one chemiluminescent NO detector, whereby the total amine concentration is determined from the difference between the detected signals for the channels.Type: ApplicationFiled: October 1, 2001Publication date: July 11, 2002Applicant: Extraction Systems, Inc.Inventors: Oleg P. Kishkovich, Devon Kinkead
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Patent number: 6416737Abstract: The present invention is a method and composition to increase bone strength in a manner that decreases fracture incidence, which may or may not include increasing bone mineral density (“BMD”). The invention includes administering an effective amount of a bisphosphonate to a host in need thereof to increase bone strength, which inhibits the apoptosis of osteoblasts and osteocytes, without a significant effect on osteoclasts. In one embodiment, the bisphosphonate is not 1-amino-3-(N,N-dimethylamino)-propyliden-1,1-bisphosphonic acid or its pharmaceutically acceptable salt. An increase in osteoblast life span can lead to an increase in bone mass, i.e., an anabolic effect. Preservation of osteocyte life span can increase bone strength, which may be disproportional to the increase in bone mass.Type: GrantFiled: November 19, 1999Date of Patent: July 9, 2002Assignee: Board of Trustees of the University of ArkansasInventors: Stavros C. Manolagas, Teresita Bellido
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Patent number: 6368870Abstract: A method is described for determining the presence of a volatile component in a test sample. The method involves use of two separate vessels, one of which is capable of being placed wholly within the other vessel. The test sample is placed in the larger vessel, and an indicator solution is placed in the smaller, inner vessel. Then a gas-tight closure is placed on the top of the outer, larger vessel. The assembly is heated to an elevated temperature, whereby the volatile target analyte which is released from the test sample transfers to the inner vessel and is absorbed by the indicator solution. The indicator solution can be analyzed by means of a calorimeter, spectrophotometer, etc.Type: GrantFiled: June 4, 1999Date of Patent: April 9, 2002Assignee: Hach CompanyInventor: Danial L. Harp
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Patent number: 6368873Abstract: This invention features methods and kits for identifying human urine samples for forensic purposes.Type: GrantFiled: April 9, 1998Date of Patent: April 9, 2002Assignee: Applied Biotech, Inc.Inventors: Shong-Ho Chang, Huiyan Guo, Trang Nguyen, Ker-Kong Tung, Yun-Fei Wei
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Patent number: 6338822Abstract: A sensor for the optical determination by fluorescence of carbon dioxide in liquid and gaseous media, which consist essentially of a carrier and a light-sensitive layer applied thereto. In addition to a polymer as a base substance and an anionic fluorescence dye, the light-sensitive layer also contains a quaternary onium phenolate.Type: GrantFiled: February 18, 2000Date of Patent: January 15, 2002Assignee: Novartis AGInventors: Adrian Waldner, Steven Mark Barnard
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Patent number: 6329206Abstract: The concentration of a hexamethylenetetramine-containing inhibitor in an acid pickling solution that has accumulated dissolved iron from use of the solution in pickling ferriferous material can be estimated with sufficient accuracy for practical control of the pickling process by alkalinizing a sample of the pickling solution to a pH of at least 10.8, so that any iron content of the solution precipitates from the solution, separating the precipitate from the liquid remainder of the alkalinized sample, and determining by colorimetry the concentration in the liquid remainder of formaldehyde produced by acid catalyzed hydrolysis of the hexamethylenetetramine to formaldehyde and ammonia.Type: GrantFiled: June 22, 1999Date of Patent: December 11, 2001Assignee: Henkel CorporationInventor: James P. Bershas
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Patent number: 6328932Abstract: This invention provides a fiber optic sensor and sensor devices for the reversible detection of basic gas analytes, including hydrazine, alkyl hydrazines, amines, ammonia, and related chemical species. The optical fiber sensor is formed in an optical fiber which conventionally comprises an optical fiber core and a cladding layer. Transducer molecules are immobilized in contact with an exposed surface of the fiber core to allow interaction of the immobilized species with analytes in the environment around the sensor. Preferred transducer molecules for detection of basic gases, particularly hydrazine and hydrazine derivatives, are xanthene dyes and triphenylmethane dyes, including malachite green and crystal violet. The sensors of this invention can be employed in a variety of device configurations including single-site sensors and multiple-site sensor networks.Type: GrantFiled: May 8, 1997Date of Patent: December 11, 2001Assignee: Eltron Research, Inc.Inventors: Michael T. Carter, Michael Schwartz
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Patent number: 6315950Abstract: A method is described for precisely controlling chlorination of wastewater and chloramination of drinking water. The method involves analyzing the water for the presence of residual monochloramine without interference of dichloramine, organic amines, organic chloramines or nitrites. A color-forming reagent is added to a sample of the water which will develop a colored compound upon reaction with monochloramine, after which the sample may be colorimetrically analyzed to determine the amount of monochloramine present. The method is very accurate and avoids the problems associated with conventional tests used for chlorination control.Type: GrantFiled: September 4, 1998Date of Patent: November 13, 2001Assignee: Hach CompanyInventors: Danial L. Harp, Patrick Wiese, Stanley Franklin
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Patent number: 6303384Abstract: This invention relates to a reagent and use of that reagent for detecting adulterants in aqueous samples, particularly in biological specimens such as urine samples using a diazo dye precursor such as N,N diethyl-1,4-phenylene diamine and a reagent such as creatinine to stabilize a colored intermediate formed by the reaction of the diamine with nitrite ions for a period sufficient to allow that color to be recorded and compared with a separate peak formed by a halogen-based oxidizing agent which may be present in solution.Type: GrantFiled: March 3, 2000Date of Patent: October 16, 2001Assignee: Quest Diagnostics Investments, Inc.Inventors: Susan P. Mills, John A. Novinski, Michael I. Schaffer
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Patent number: 6296806Abstract: A detection system for detecting base contamination at low concentrations in gas, for instance to protect a sensitive process, characterized in that the detection system is constructed to examine multiple amines in gas to produce a reading stoichiometrically related to the proton bonding characteristic of the multiple amines present, the detection system comprising at least two channels through which a gas to be examined passes, an amines remover located in one of the channels, at least one thermal/catalytic converter which discharges NO for each channel, and at least one chemiluminescent NO detector, whereby the total amine concentration is determined from the difference between the detected signals for the channels.Type: GrantFiled: December 23, 1997Date of Patent: October 2, 2001Assignee: Extraction Systems, Inc.Inventors: Oleg P. Kishkovich, Devon A. Kinkead
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Patent number: 6258606Abstract: An improved biologic electrode array and methods for manufacturing and using the same. In one aspect, a matrix of electrodes each coupled to a respective sample-and-hold circuit is provided. The electrodes and sample-and-hold circuits are integral and form an array within a single semiconductor chip, such that each sample-and-hold circuit may be loaded with a predefined voltage provided by a single, time-shared digital-to-analog converter (DAC). Further, all of the sample-and-hold circuits may be accessed through a multiplexer which may be scanned through some or all of the electrode locations. Each sample-and-hold circuit may comprise a capacitor and one or more transistor switches, the switch(es), when closed, providing electrical communication between the capacitor and a source line formed in the matrix.Type: GrantFiled: July 30, 1999Date of Patent: July 10, 2001Assignee: Nanogen, Inc.Inventor: Gregory T. A. Kovacs
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Patent number: 6255066Abstract: A screening test for bacterial vaginosis is performed by (a) combining a sample of vaginal fluid with a developer reagent selected from the group consisting of phenol, derivatives thereof, and mixtures thereof to form a first reaction medium; (b) combining the first reaction medium with a water soluble base and a halogen-containing oxidizing agent to form a second reaction medium having a pH of at least about 9.5; and (c) observing the color of the second reaction medium. The concentration of the halogen-containing oxidizing agent in the second reaction medium is about 0.12 or greater (on a molar basis) than the concentration of the developer reagent in the second reaction medium. The foregoing procedure can be used to test for the presence of amines in any aqueous fluid as well as for synthesizing various dyes.Type: GrantFiled: February 8, 2000Date of Patent: July 3, 2001Inventor: Allan L. Louderback
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Patent number: 6248595Abstract: The invention relates to apparatus and a method for measuring NOx in biochemical processes, and to apparatus and methods for real time measuring the nitrification and/or denitrification rate of a liquid with or without suspended solids.Type: GrantFiled: April 23, 1999Date of Patent: June 19, 2001Assignee: BioChem Technology, Inc.Inventors: Jaw Fang Lee, Sergey K. Maneshin, Marcus E. Kolb, Xin Yang
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Patent number: 6225050Abstract: Cyanine and related dyes, such as merocyanine, styryl and oxonol dyes, are strongly light-absorbing and highly luminescent. Cyanine and related dyes having functional groups make them reactive with amine, hydroxy and sulfhydryl groups are covalently attached to proteins, nucleic acids, carbohydrates, sugars, cells and combinations thereof, and other biological and nonbiological materials, to make these materials fluorescent so that they can be detected. The labeled materials can then be used in assays employing excitation light sources and luminescence detectors. For example, fluorescent cyanine and related dyes can be attached to amine, hydroxy or sulfhydryl groups of avidin and to antibodies and to lectins. Thereupon, avidin labeled with cyanine type dyes can be used to quantify biotinvlated materials and antibodies conjugated with cyanine-type dyes can be used to detect and measure antigens and haptens. In addition, cyanine-conjugated lectins can be used to detect specific carbohydrate groups.Type: GrantFiled: November 12, 1996Date of Patent: May 1, 2001Assignee: Carnegie Mellon UniversityInventor: Alan S. Waggoner
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Patent number: 6207460Abstract: A detection system for detecting contaminant gases includes a converter, a detector, a primary channel for delivering a target gas sample through the converter to the detector, and at least two scrubbing channels for delivering a reference gas sample through the converter to the detector. Each of the scrubbing channels includes a scrubber for removing basic nitrogen compounds from the reference gas sample, while the primary channel preferably transmits the target gas sample without scrubbing. The converter converts gaseous nitrogen compounds in the target gas sample to an indicator gas, such as nitric oxide (NO), and a control system directs the flow of a gas sample among the primary channel and the scrubbing channels. In accordance with one aspect of the invention, the basic-nitrogen-compound concentration can be measured by comparing the concentration of the indicator gas detected in the reference sample with the detected indicator-gas concentration in the target sample.Type: GrantFiled: January 14, 1999Date of Patent: March 27, 2001Assignee: Extraction Systems, Inc.Inventors: Oleg P. Kishkovich, William M. Goodwin
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Patent number: 6204067Abstract: The present invention discloses the mechanism of tamoxifen mediated inhibition of acidification. This mechanism information is then used to design methods of identifying compounds that will have the pharmaceutical effect of tamoxifen without the corresponding side-effects.Type: GrantFiled: June 17, 1999Date of Patent: March 20, 2001Assignee: Board of Trustees Operating Michigan State UniversityInventors: Sanford M. Simon, Melvin S. Schindler, Yu Chen
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Patent number: 6200817Abstract: Tests for elevated pH and volatile amines in aqueous fluids are disclosed, including tests useful in the diagnosis of bacterial vaginosis and in other biological conditions. By using formulated indicators and indicators held in matrices that are permeable to gas but not to liquid, the tests provide clear and sharp transitions detectable by visual or machine-readable device rather than by subjective judgments such as small gradations in color or olfactory determinations. The tests lend themselves readily to iconic readouts of the test indications and to the inclusion of positive and negative controls.Type: GrantFiled: March 17, 1998Date of Patent: March 13, 2001Assignee: Litmus Concepts, Inc.Inventor: Paul J. Lawrence
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Patent number: 6194216Abstract: The invention concerns a method for determining the presence and quantity of an amine-based additive in fluids, particularly aqueous fluids used in hydrocarbon recovery such as drilling fluids, drill-in fluids, completion fluids, and the like. It was discovered that, after isolating the amine-based additive, the amount of clay stabilizer is linearly dependent upon the spectrometric count of its peak fluorescent spectrum. The method is reproducible and is not bothered by the presence of lignosulfonate and/or lignite which interferes with conventional methods.Type: GrantFiled: February 16, 2000Date of Patent: February 27, 2001Assignee: Baker Hughes IncorporatedInventors: Nyal S. Walker, Michael A. Jarrett, Dennis K. Clapper
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Patent number: 6136801Abstract: Quantitative compliance markers and associated methods for monitoring patient compliance with medication prescriptions associated with compliance markers have been found to eliminate the need for specific quantitative relationships for each new drug tested. Such compliance markers and methods for monitoring patient compliance utilize pharmacologically inert substances, namely the weak acids benzodiazepines, or non-metabolizable substances in association with an underlying drug at a measurable dosage, so as to correlate compliance marker concentration with underlying medication concentration to determine amount of actual medication ingested.Type: GrantFiled: December 24, 1998Date of Patent: October 24, 2000Assignee: U. D. Testing, Inc.Inventor: Michael Kell
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Patent number: 6127189Abstract: The invention includes compositions comprising and methods of using 1,2-indanedione derivatives for detecting an amine compound such as an amino acid. Methods of detecting and recording the pattern of a fingerprint on a surface are also included, as are a kit for detecting an amine compound such as a constituent of a fingerprint. The invention further includes a device for developing a fingerprint and a method of making 1,2-indanedione derivatives.Type: GrantFiled: November 7, 1997Date of Patent: October 3, 2000Assignee: The Trustees of the University of PennsylvaniaInventors: Madeleine M. Joullie, Diane Hauze, Olga Petrovskaia
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Patent number: 6124136Abstract: A method of monitoring compliance of a patient that has been placed on a methadone maintenance program by determining plasma methadone concentration from urine methadone concentration. An unadulterated urine sample is obtained from the patient. The urine methadone concentration, pH, and specific gravity are measured. The plasma methadone concentration is calculated as a function of urine methadone concentration, specific gravity, and pH. The calculated plasma methadone concentration is compared with an expected value for the maintenance program prescribed.Type: GrantFiled: November 2, 1993Date of Patent: September 26, 2000Assignee: U. D. Testing, Inc.Inventor: Michael Kell
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Patent number: 6117940Abstract: A solid support template for solid phase synthesis of amino group containing compounds is provided that comprises amino-ketone core compounds of the general formula:A-L-NH(CR.sub.1 R.sub.2).sub.n COR.sub.3linked to appropriate insoluble substrates to create solid support templates having the general formula:Polymer-X-L-NH(CR.sub.1 R.sub.2).sub.n COR.sub.3where L is a multifunctional monomer carrying a first functional group that forms a covalent bond with X and a second functional group comprising an amine and L, R.sub.1, R.sub.2 and R.sub.3 are selected from the group consisting of alkyl, alkyl-aryl, alkenyl, alkenyl-aryl groups having up to 6 carbon atoms and substituted forms thereof. The amino-ketone templates are useful for the solid phase synthesis of compounds such as the imidazoles, benzodiazepines, pyrazines, and steroid mimics.Type: GrantFiled: October 16, 1998Date of Patent: September 12, 2000Inventor: Adnan M. M. Mjalli
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Patent number: 6096267Abstract: A system for detection of base contamination at low concentrations in air comprises a detector that provides a single reading that is stoichiometrically related to the aggregate proton-bonding characteristic of various base contaminants present in the air. The system can operate as a "total amine detector" for air-borne amines, and in important implementations is employed in semiconductor manufacturing, e.g. in respect of incoming or exhaust air from a cleanroom or in respect of the stepper or coat and develop track of a photolithographic process. The system comprises a converter for converting all amines present in the air to a common detectable compound detected by the detector. In various implementations additional features are shown. The converter is located near a sample region of a process and the detector is remotely located with sample lines extending between converter and detector to conduct a sample flow. Filters provide air free of amine contaminants to various stages of a process.Type: GrantFiled: February 28, 1997Date of Patent: August 1, 2000Assignee: Extraction Systems, Inc.Inventors: Oleg P. Kishkovich, Devon A. Kinkead
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Patent number: 5981288Abstract: The present invention provides for a method and system for determining the concentration of a surfactant in a transparent hydrocarbon by performing the steps of adding a solid to the hydrocarbon; adding a second masking reagent to the hydrocarbon; mixing to form a dispersion; separating the dispersion from the mixture; and measuring the optical absorption of the dispersion.Type: GrantFiled: October 14, 1997Date of Patent: November 9, 1999Assignee: BetzDearborn Inc.Inventors: Wiley L. Parker, Alan E. Goliaszewski, Nancy R. Calvert
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Patent number: 5976887Abstract: A novel electrochemiluminescent (ECL) reaction between diaminoaromatic ligands and soluble metal ions, specifically reactions between aminoaromatic ligands, such as 2,4-diaminotoluene (2,4,DAT), 3,4-diaminotoluene (3,4,DAT) and 2,3-diaminonaphthalene (2,3-DAN) and metal ions such as Au(I), Cu(II), Cr(VI), Fe(III), Ru)III), Se(IV) and V(V). Such reactions form the basis for ECL assays in detection of various substances, such as the reactants. The ECL interaction between these substances can also form the basis for binding methods in the detection of other substances, such as nucleic acids and antibodies wherein the metal ion ligand ECL complex may be used as a label. The ECL assays are considered useful for carrying out field and laboratory analyses for the detection of TNT breakdown products and toxic metals in wastewater streams, soil, and ground water supplies.Type: GrantFiled: June 2, 1997Date of Patent: November 2, 1999Assignee: Applied Research Associates, Inc.Inventors: John G. Bruno, Jimmy C. Cornette
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Patent number: 5968835Abstract: To estimate nitric acid ions and nitrous acid ions in a sample solution, a method is proposed which comprises the steps of (a) feeding both the sample solution and a reducing agent to an acidic solution which is flowing in a thin pipe; (b) positively mixing the sample solution and the reducing agent and thus reacting the same in a given portion of the pipe; (c) leading the reacted solution to a gas/liquid separator thereby to separate a gaseous phase from the reacted solution; and (d) estimating the nitric acid ions and nitrous acid ions in the gaseous phase.Type: GrantFiled: February 27, 1997Date of Patent: October 19, 1999Assignee: Kabushiki Kaisha MeidenshaInventors: Toyoaki Aoki, Hiroshi Tsugura
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Patent number: 5968837Abstract: In a method for photo-ionization ion mobility spectrometry, a reagent gas is added, in particular an aromatic compound, which has a large ionization cross section in the range of ionizing VUV radiation, but a low probability for the formation of protonated quasi-molecular ions. In this way, the detection of only weakly proton affine substances is also amplified or even made possible at all, and also the detection of electronegative substances in a negative operating mode is improved. Preferred reagent gases are benzene, toluene and xylene. FIG.Type: GrantFiled: March 11, 1997Date of Patent: October 19, 1999Assignee: Bruker-Saxonia Analytik GmbHInventors: Hans-Rudiger Doring, Gerd Arnold, Joachim Adler, Thomas Robel, Jurgen Riemenschneider
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Patent number: 5965452Abstract: An improved biologic electrode array and methods for manufacturing and using the same. In one aspect, a matrix of electrodes each coupled to a respective sample-and-hold circuit is provided. The electrodes and sample-and-hold circuits are integral and form an array within a single semiconductor chip, such that each sample-and-hold circuit may be loaded with a predefined voltage provided by a single, timeshared digital-to-analog converter (DAC). Further, all of the sample-and-hold circuits may be accessed through a multiplexer which may be scanned through some or all of the electrode locations. Each sample-and-hold circuit may comprise a capacitor and one or more transistor switches, the switch(es), when closed, providing electrical communication between the capacitor and a source line formed in the matrix.Type: GrantFiled: July 9, 1996Date of Patent: October 12, 1999Assignee: Nanogen, Inc.Inventor: Gregory T. A. Kovacs
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Patent number: 5965448Abstract: A flow injection analytical apparatus which is capable of continuously performing flow analysis of a sample, produces precipitates during the flow through a capillary. The precipitation separation type continuous flow analytical apparatus has a sample injection portion, a reagent addition portion and an analytical portion which are integrally communicated by a measurement pipeline to form a measurement system. A precipitant addition portion and a filtration portion are provided between the sample injection portion and the reagent addition portion in order to continuously perform production and filtration of precipitates during flow of the sample solution to the reagent addition portion.Type: GrantFiled: September 30, 1997Date of Patent: October 12, 1999Assignee: Mitsubishi Materials CorporationInventors: Masaaki Katou, Yutaka Hayashibe, Minoru Takeya, Yasumasa Sayama
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Patent number: 5962328Abstract: An electrolytic solution for Karl Fischer coulometric titration is disclosed which consists mainly of an amine, sulfur dioxide, iodide ions, and a solvent which is a mixed solvent comprising (a) propylene carbonate and (b) a dialkylene glycol monoalkyl ether (wherein the alkylene groups and the alkyl group each have from 1 to 4 carbon atoms). The electrolytic solution, which is based on a less toxic solvent, has fewer side reactions with ketones and is useful in accurately determining the water content of ketones.Type: GrantFiled: June 25, 1997Date of Patent: October 5, 1999Assignee: Mitsubishi Chemical CorporationInventors: Hiromasa Kato, Naoko Katayama
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Patent number: 5955370Abstract: A test method for determining adulteration by diuresis or the addition of a diuretic, which uses creatinine and specific gravity measurements to determine a normalized creatinine value for comparison with expected normalized creatinine values for the substantially diuretic-free population.Type: GrantFiled: July 7, 1997Date of Patent: September 21, 1999Assignee: U.D. Testing, Inc.Inventor: Michael Kell
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Patent number: 5916815Abstract: An assaying system for determining the presence of particular illicit substances in human physiological fluid, consisting of a collection cup, a collection cup lid, and a test card with assaying means, quality control means and adulteration detection means which is secured to the collection cup lid. The assaying means contemplate the addition of control positives such that a pre-determined number of assaying systems would be configured so that a false positive indication would be given by the assaying means in addition to any true positive results which may be present. Accordingly, it would initially be impossible to distinguish true test-positives from control positives, and thus the anonymity of a true test-positive donor individual would be protected. All donor individuals testing negative would be immediately discernible.Type: GrantFiled: February 14, 1997Date of Patent: June 29, 1999Assignee: National Medical Review Office Inc.Inventor: Murray Lappe
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Patent number: 5910447Abstract: Tests for elevated pH and volatile amines in aqueous fluids are disclosed, including tests useful in the diagnosis of bacterial vaginosis and in other biological conditions. By using formulated indicators and indicators held in matrices that are permeable to gas but not to liquid, the tests provide clear and sharp transitions detectable by visual or machine-readable means rather than by subjective judgments such as small gradations in color or olfactory determinations. The tests lend themselves readily to iconic readouts of the test indications and to the inclusion of positive and negative controls.Type: GrantFiled: March 18, 1997Date of Patent: June 8, 1999Assignee: Litmus Concepts, Inc.Inventors: Paul J. Lawrence, Peter U. Ly, David R. Shockey
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Patent number: 5908788Abstract: A method of monitoring compliance of a patient that has been placed on a medication maintenance program with a prescribed medication dosage by determining a normalized urine methadone concentration. An unadulterated urine sample is obtained from the patient. The urine methadone concentration and urine specific gravity are measured. The normalized urine medication concentration is calculated as a function of the measured medication concentration in the urine and the urine specific gravity. The calculated normalized urine medication concentration is compared with an expected medication concentration value for the patient for the maintenance program prescribed to determine any significant differences therebetween as an indication of noncompliance. Alternatively, a urinary-parameter normalized urine medication concentration is calculated as a function of the measured medication concentration in the urine, the urine specific gravity and at least one selected pharmacokinetic parameter of the medication.Type: GrantFiled: August 19, 1996Date of Patent: June 1, 1999Assignee: U.D. Testing, Inc.Inventor: Michael Kell
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Patent number: 5882937Abstract: Ammonia monitor and method of use are disclosed. A continuous, real-time determination of the concentration of ammonia in an aqueous process stream is possible over a wide dynamic range of concentrations. No reagents are required because pH is controlled by an in-line solid-phase base. Ammonia is selectively transported across a membrane from the process stream to an analytical stream under pH control. The specific electrical conductance of the analytical stream is measured and used to determine the concentration of ammonia.Type: GrantFiled: July 9, 1997Date of Patent: March 16, 1999Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Richard L. Sauer, James R. Akse, John O. Thompson, James E. Atwater
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Patent number: 5877027Abstract: An analytical method for the quantitative determination of the impurities in silicon dioxide by which trace amounts of hardly soluble impurities contained in silicon dioxide can be reliably decomposed and converted into a solution so that the contents of all of the impurities contained in silicon dioxide or, in particular, zirconium in a natural quartz powder can be accurately determined. Silicon dioxide is decomposed with hydrofluoric acid or an acid mixture of hydrofluoric acid and another inorganic acid to give a decomposition solution which is, as such or after admixture with another inorganic acid, subjected to evaporation to dryness and the residue is heated to cause fusion with addition of a salt or hydroxide of an alkali metal followed by dissolution of the salt or hydroxide of an alkali metal with pure water or with an aqueous solution of an inorganic acid to give an aqueous solution which is subjected to quantitative analysis of the impurities therein.Type: GrantFiled: August 27, 1997Date of Patent: March 2, 1999Assignee: Shin-Etsu Quartz Products Co., Ltd.Inventors: Katsuhiko Kemmochi, Kiyotaka Maekawa, Chuzaemon Tsuji, Manabu Saitou, Hiroyuki Miyazawa, Hiroyuki Watanabe
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Patent number: 5874314Abstract: In a technique for detecting organic vapors and aerosols, e.g. of amines, hydrazines and nitrogen-containing compounds produced in combustion, molecules condense at a surface of a conductive device. By heating the conductive device in pulsed fashion, e.g. by resistance heating, condensed molecules are thermally ionized and emitted from the conductive device. Emitted ions are collected by a collector electrode, and the resulting ionic current pulse is amplified by a transimpedance circuit. The heat pulse lasts until the ionic current pulse has subsided, by which time the conductive device has become free of residual substances. As a result, the conductive device remains uncontaminated and has a long service life. The time-averaged power consumption of the technique is less than 2 mW. For resistance heating, a meander heater element can be disposed on a silicon nitride membrane across an etched opening in a silicon chip.Type: GrantFiled: January 31, 1997Date of Patent: February 23, 1999Assignee: Cerberus AGInventors: Markus Loepfe, Dieter Wieser, Peter Ryser
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Patent number: 5872008Abstract: A method for diagnosing premenstrual syndrome in a female human comprising the step of measuring the ratio of esterified L-carnitine to free L-carnitine in a patient's serun or plasma. Women who have an esterified to free L-carnitine ratio of greater than about 0.22 are diagnosed as having premenstrual syndrome.Type: GrantFiled: February 9, 1996Date of Patent: February 16, 1999Inventors: Glenn O. Bair, Austin Shug
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Patent number: 5866075Abstract: A device for sensing ammonia (NH.sub.3) and nitrogen oxide (NO.sub.x) gases comprising: a sensor for detecting said ammonia and said nitrogen oxide gases, said sensor including a substrate and a layer consisting of cuprate material for detection of said ammonia and said nitrogen oxide gases, wherein said layer of cuprate material is selected from the group consisting of Y:Ba:Cu:O (YBCO) and Bi:Sr:Ca:Cu:O (BSCCO); a sensor holder for supporting said sensor; a perforated cap positioned over said sensor, said perforated cap having openings for passage of said ammonia and said nitrogen oxide gases to said sensor; a detection circuit communicating with said sensor for measuring output from said sensor; and a display or recording device connected to said detection circuit for displaying or recording a concentration of said ammonia and said nitrogen oxide gases based on the output from said sensor.Type: GrantFiled: December 29, 1997Date of Patent: February 2, 1999Assignee: Council of Scientific and Industrial ResearchInventors: Ram Pratap Gupta, Purushottam Das Vyas, Zenko Gergintschew, Dagmar Schipanski
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Patent number: 5858798Abstract: Primary amines, ammonia, or mixtures thereof can be detected using a reagent comprising from about 650 ppm to about 25 percent by weight of phthalic dicarboxyaldehyde; from about 74 to about 99.88 percent by weight of an alkali metal borate; and, from about 550 ppm to about 22 percent by weight of a nucleophile.Type: GrantFiled: July 12, 1996Date of Patent: January 12, 1999Assignee: Nalco Chemical CompanyInventors: Martin R. Godfrey, Donald E. Govoni, Linda M. Link
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Patent number: 5824559Abstract: A method and a device for the analysis of 5-hydroxyindoles or catecholamines with high sensitivity. New chemiluminescence labeling agents, 6-aminomethylphthalhydrazide or 1,2-bis(phthalhydrazino)ethylenediamine, are reacted with 5-hydroxyindoles or catecholamines to form their stable derivatives. The derivatives emit strong luminescence in the presence of an oxidizing agent. In the chemiluminescence detection method, there is extremely low background noise and thus the method enables analysis with high sensitivity.Type: GrantFiled: June 17, 1996Date of Patent: October 20, 1998Assignee: Laboratory of Molecular BiophotonicsInventors: Hitoshi Nohta, Masatoshi Yamaguchi, Junichi Ishida, Kivoshi Zaitsu, Hiroko Iida
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Patent number: 5814664Abstract: The present invention relates to advanced glycosylation endproducts, and particularly to the use of novel cyclopentenone aminoreductones, 3-alkylamino-2 -hydroxy-4-hydroxymethyl-2-cyclopenten-1-ones. Such AGEs can be used in various diagnostic and therapeutic methods.Type: GrantFiled: June 23, 1997Date of Patent: September 29, 1998Assignee: Picower Institute for Medical ResearchInventors: Peter C. Ulrich, Xini Zhang
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Patent number: 5786167Abstract: The invention comprises a culture medium and method for distinguishing bacteria of Salmonella species from other gram-negative bacteria, especially those belonging to the family Enterobacteriaceae. It is based on the ability of salmonellae to utilize melibiose, mannitol, and sorbitol and convert them into acids, together with a chromogenic substrate used for identifying .beta.-galactosidase. Other bacteria of the family Enterobacteriaceae, most of which are .beta.-galactosidase-positive, appear as brown, blue, or green colonies, depending on the chromogenic substrate used. Apart from Salmonella species, other .beta.-galactosidase-negative bacteria, such as Proteus species, appear as colorless colonies. Salmonellae can be identified directly on the culture medium after incubation, by their characteristic bright red color.Type: GrantFiled: November 22, 1996Date of Patent: July 28, 1998Assignee: Orion-Yhtymae OyInventors: Helena Tuompo, Leena Scheinin, Marita Jussila, Irmeli Laine
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Patent number: 5783450Abstract: A method and an instrument for separating and analyzing a very small quantity of constituents to be inspected contained in an analyte such as a class of catecholamines by liquid chromatography after labeling. The entire processes of analytical operations include principally three processes, a preparing process, an impurity elimination process and a separation process. When one sample is perceived, the sample is processed in these three processes. In this case, while one sample is being processed in an impurity elimination process, a sample preceeding the one sample is processed in a separation process, and a succeeding sample is processed in a preparing process. In other words, these three processes are performed essentially in parallel. With this, it is possible to remarkably reduce analysis time as compared with individual single sample analysis.Type: GrantFiled: May 12, 1995Date of Patent: July 21, 1998Assignee: Hitachi, Ltd.Inventors: Kasumi Yoshida, Junkichi Miura, Yoshio Fujii, Hiroshi Satake, Masahito Ito, Masao Kamahori
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Patent number: 5783577Abstract: The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.Type: GrantFiled: September 13, 1996Date of Patent: July 21, 1998Assignee: Trega Biosciences, Inc.Inventors: Richard A. Houghten, John M. Ostresh
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Patent number: 5776783Abstract: Quantitative compliance markers and associated methods for monitoring patient compliance with medication prescriptions associated with compliance markers have been found to eliminate the need for specific quantitative relationships for each new drug tested. Such compliance markers and methods for monitoring patient compliance utilize pharmacologically inert substances, namely the weak acids benzodiazepines, or non-metabolizable substances in association with an underlying drug at a measurable dosage, so as to correlate compliance marker concentration with underlying medication concentration to determine amount of actual medication ingested.Type: GrantFiled: September 17, 1996Date of Patent: July 7, 1998Assignee: Private Clinic Laboratories, Inc.Inventor: Michael Kell