Hydroxyl Containing Patents (Class 436/131)
  • Patent number: 10267810
    Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally directed to ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: April 23, 2019
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel J. Clarke, Brett Holmquist, Gloria Kwang-Ja Lee, Richard E. Reitz
  • Patent number: 9574994
    Abstract: A detector receives optical radiation interacted with the measured sheet and is responsive to a predetermined optical absorption band of lignin, a predetermined optical absorption band of dry matter and two or more separate optical bands. The measuring unit measures a lignin dependent value on the basis of attenuation in the absorption band of lignin, and a dry matter dependent value on the basis of attenuation in the absorption band of the dry matter, and determines a general dependence of attenuation with respect to wavelength by measuring attenuations in the separate optical bands. The measuring unit forms a value representing a dry matter content on the basis of the lignin dependent value, the dry matter dependent value and the general dependence of attenuation.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: February 21, 2017
    Assignee: METSO AUTOMATION OY
    Inventor: Markku Mäntylä
  • Patent number: 9201079
    Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise associating an amine with a dihydroxyvitamin D metabolite in a sample, ionizing the adduct, and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample.
    Type: Grant
    Filed: October 19, 2010
    Date of Patent: December 1, 2015
    Assignee: Georgetown University
    Inventor: Steven J. Soldin
  • Patent number: 9068997
    Abstract: Disclosed is an apparatus for automatically extracting i2,6-diisopropylphenol (Propofol), from a complex sample matrix comprising cellular material, e.g.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: June 30, 2015
    Assignee: SPHERE MEDICAL LIMITED
    Inventors: David Michael Pettigrew, Bo Liu, Peter Georg Laitenberger, Stephen Bates
  • Patent number: 9068996
    Abstract: Disclosed is a method of determining the presence of an analyte of interest by means of a detection of a reaction product between the analyte of interest and a reactant, the method comprising extracting the analyte of interest from a complex sample matrix; transferring the analyte of interest to an initial reaction mixture; performing a background measurement on the initial reaction mixture comprising at most a negligible concentration of the reaction product, wherein the reaction conditions present in said initial reaction mixture at least reduce the reaction rate of the formation of the reaction product such that the background measurement can be performed without a measurable change in said negligible concentration; altering the reaction conditions in the initial reaction mixture to accelerate said reaction rate; continuing said reaction until the concentration of the reaction product has stabilized; performing a second measurement on the resultant reaction mixture to obtain a signal correlated to said con
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: June 30, 2015
    Assignee: SPHERE MEDICAL LIMITED
    Inventors: David Michael Pettigrew, Peter Georg Laitenberger, Bo Liu
  • Patent number: 9029164
    Abstract: An improved analytical method for analysis of dianhydrogalactitol preparations provides a method for determining the purity of dianhydrogalactitol and detecting impurities in preparations of dianhydrogalactitol, as well as identifying any such impurities. The method employs high performance liquid chromatography (HPLC), in particular, HPLC with evaporative light scattering detection (ELSD); the HPLC can be followed by tandem mass spectroscopy. The method can further comprise the step of performing preparative HPLC collection of at least one specific substance peak present in a preparation of dianhydrogalactitol.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: May 12, 2015
    Assignee: Del Mar Pharmaceuticals
    Inventors: Xiaoyun Lu, Mike Tso-Ping Li
  • Publication number: 20150080263
    Abstract: The present invention is directed to methods for predicting a pregnant woman's risk of carrying a fetus with Down syndrome (Trisomy 21) or Trisomy 18. The methods are based on measuring one or more metabolites obtained from a pregnant woman's bodily fluid, such as blood or urine, and found to be predictive of Trisomy 21 or Trisomy 18.
    Type: Application
    Filed: April 12, 2013
    Publication date: March 19, 2015
    Inventors: Ray O. Bahado-Singh, Kypros Nicolaides
  • Publication number: 20150065365
    Abstract: An apparatus is provided for sensing an analyte in a fluid.
    Type: Application
    Filed: May 12, 2014
    Publication date: March 5, 2015
    Applicant: Invoy Technologies, L.L.C
    Inventor: Lubna Ahmad
  • Patent number: 8969084
    Abstract: A method that identifies the compounds contributing to a sweet odor from an air conditioner, reproduces the sweet odor, and prepares a corresponding sweet odor composition. Through the analysis method of the present invention, the compounds contributing to the sweet odor from an air conditioner are identified and quantified. The sweet odor is reproduced from a combination of the compounds identified by the analysis method of the present invention. The reproduced sweet odor provides significant data required for development of an apparatus and a method for removing specific odor.
    Type: Grant
    Filed: July 26, 2013
    Date of Patent: March 3, 2015
    Assignee: Hyundai Motor Company
    Inventors: Tae Hee Lee, Ji Wan Kim, Seok Man Kim, Sang Jun Lee
  • Publication number: 20150051111
    Abstract: A method is described for mass spectrometric analysis of a sample comprising phenolic OH, such as a steroid comprising a phenolic OH, using a quaternary amino oxy Cookson (QAOC) reagent. The QAOC reagent can improve ionization and fragmentation properties of phenolic OH samples, which can thereby improve quantitation and identification. The method can include derivatizing the phenolic OH sample with the QAOC reagent to create an adduct and analyzing the adduct using mass spectrometry. Derivatization of the sample can be a one-step reaction where the QAOC reagent comprises an aminooxy MS tag or can be a multi-step reaction, where the adduct is formed by the reaction of carbonyl substituted PTAD based reagent and the sample followed by combination with an aminooxy MS tag. The sample can also be enriched prior to reacting it with the reagent. The method can also allow for multiplexing.
    Type: Application
    Filed: January 16, 2013
    Publication date: February 19, 2015
    Inventors: Subhakar Dey, Subhasish Purkayastha
  • Publication number: 20150024506
    Abstract: A reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein, an in vitro method for the detection of a vitamin D compound in which the vitamin D compound is released from vitamin D-binding protein by the use of this reagent composition and the reagent mixture obtained in this manner. The use of the disclosed reagent composition to release vitamin D compounds as well as a kit for detecting a vitamin D compound which contains the reagent composition for releasing vitamin D compounds in addition to common detecting reagents.
    Type: Application
    Filed: September 30, 2014
    Publication date: January 22, 2015
    Inventors: Sascha Antoni, Christian Vogl
  • Patent number: 8936943
    Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: January 20, 2015
    Assignee: Quest Diagnostics Investments, Inc.
    Inventors: Nigel J. Clarke, Brett Holmquist, Gloria Kwang-Ja Lee, Richard E. Reitz
  • Publication number: 20140315318
    Abstract: An improved analytical method for analysis of dianhydrogalactitol preparations provides a method for determining the purity of dianhydrogalactitol and detecting impurities in preparations of dianhydrogalactitol, as well as identifying any such impurities. The method employs high performance liquid chromatography (HPLC), in particular, HPLC with evaporative light scattering detection (ELSD); the HPLC can be followed by tandem mass spectroscopy. The method can further comprise the step of performing preparative HPLC collection of at least one specific substance peak present in a preparation of dianhydrogalactitol.
    Type: Application
    Filed: November 18, 2013
    Publication date: October 23, 2014
    Applicant: Del Mar Pharmaceuticals
    Inventors: Xiaoyun Lu, Mike Tso-Ping LI
  • Patent number: 8852951
    Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydroxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: October 7, 2014
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel J. Clarke, Anne Caston-Balderrama, Richard E Reitz
  • Publication number: 20140287514
    Abstract: The present invention includes a sensing device and method detecting the presence of a chemical analyte, comprising: a surface; a continuous or discontinuous terbium(III)-triphenylphosphine oxide coordination polymer layer deposited on the surface, wherein the polymer layer is porous; and a luminescence detector, wherein one or more analytes that interact with the polymer layer luminesce at distinct wavelengths unique to each analyte.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 25, 2014
    Inventors: Simon M. Humphrey, Bradley J. Holliday
  • Publication number: 20140273260
    Abstract: The present invention comprises methods for determining the presence, amount, or concentration of analytes of interest including Vitamin D and other secosteroids from biological samples, through derivatization, with improved speed and ease of analysis and improved sensitivity to mass spectrometry. In a preferred embodiment, the present invention comprises methods for determining the presence, amount, or concentration of analytes of interest, including Vitamin D and other secosteroids from whole human blood, through derivatization, and using a plasma collection device to facilitate collection, separation, and preparation of the sample for derivatization and analysis.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Applicant: Novilytic, LLC
    Inventors: Fred Regnier, Jinhee Kim, Jiri Adamec, Timothy E. woenker, Richard P. Zoltek, Wenchu Yang
  • Publication number: 20140248707
    Abstract: A reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein and an in vitro method for the detection of a vitamin D compound in which the vitamin D compound is released from vitamin D-binding protein by the use of this reagent composition as well as the reagent mixture obtained in this manner. Also disclosed is the use of the reagent compositions to release vitamin D compounds as well as a kit for detecting a vitamin D compound.
    Type: Application
    Filed: May 14, 2014
    Publication date: September 4, 2014
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Sascha Antoni, Christian Vogl
  • Publication number: 20140242712
    Abstract: The invention herein disclosed provides for compositions, methods for synthesizing said compositions, and methods for using said compositions, wherein the compositions and methods may be used to bind to and/or deactivate a poison oak oil, such as urushiol. The compositions and methods can be used to treat and/or reduce an inflammatory reaction and/or hypersensitivity to natural compounds found in poison oak, poison ivy, poison sumac, mango, lac tree, and cashew nut.
    Type: Application
    Filed: May 6, 2014
    Publication date: August 28, 2014
    Applicant: The Regents of the University of California
    Inventor: Rebecca Braslau
  • Publication number: 20140234977
    Abstract: Field-effect transistors include at least two thin layers of a semiconductor material and of an electrically conductive gate material that are rolled up together. These two layers are arranged separated from one another by one or multiple barrier layers and this rolled-up multi-layer structure is integratable as field-effect transistors in circuits and/or in microfluid systems as sensors for the detection of fluids.
    Type: Application
    Filed: December 2, 2013
    Publication date: August 21, 2014
    Applicant: LEIBNIZ-INSTITUT FUER FESTKOERPER-UND WERKSTOFFFORSCHUNG DRESDEN E.V
    Inventors: Daniel GRIMM, Oliver G. SCHMIDT, Carlos Cesar Bof BUFON
  • Patent number: 8785204
    Abstract: The invention provides a method of assaying for tetrahydrocannabinol in a body fluid. The method includes contacting a sample of body fluid with an imine capable of reacting with tetrahydrocannabinol to yield a quinone imine, and detecting the formation of a quinone imine, where the sample is contacted with the reagent compound at a pH of at least 10.5.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: July 22, 2014
    Assignee: Oxtox Limited
    Inventors: Dimitrios Konstantinos Kampouris, Patrick Robinson Huddleston, Craig Edward Banks
  • Publication number: 20140162371
    Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
    Type: Application
    Filed: February 14, 2014
    Publication date: June 12, 2014
    Applicant: Quest Diagnostics Investments Incoporated
    Inventors: Nigel J. Clarke, Brett Holmquist, Gloria Kwang-Ja Lee, Richard E. Reitz
  • Patent number: 8748190
    Abstract: The present invention provides methods for detecting urushiol-bearing plants such as poison ivy, poison oak, and poison sumac. Accordingly, one aspect of the invention is a method of detecting a urushiol-bearing plant, the method comprising: dispensing a urushiol marking composition on a surface of the urushiol-bearing plant; then detecting a visual change on the urushiol-bearing plant caused by the reaction of the urushiol marking composition with the urushiol borne by the urushiol-bearing plant.
    Type: Grant
    Filed: March 25, 2010
    Date of Patent: June 10, 2014
    Inventor: Alisha Hansen
  • Publication number: 20140154700
    Abstract: Compounds include carbamate derivatives of vitamin D including vitamin D3 and vitamin D2. The compounds are useful in methods and kits for determining the presence and/or amount of vitamin D including vitamin D analogs and metabolites thereof in a sample suspected of containing the same.
    Type: Application
    Filed: November 30, 2012
    Publication date: June 5, 2014
    Inventors: Zhu Teng, Roland Janzen, Martin A. Drinan
  • Publication number: 20140147878
    Abstract: Systems, kits, and methods for quantitation of metabolites of vitamin D by liquid chromatography-mass spectrometry (LC-MS). The systems, kits, and methods described herein stabilize and/or promote the formation of the protonated molecular ion ([M+H]+) for the vitamin D metabolites in the ionization source (e.g., electrospray ionization (“ESI”)). Formation of the molecular ion does not involve loss of a water molecule from the parent molecule. Subsequent fragmentation of the [M+H]+ ion yields product ions that are specific to each molecular ion. The systems, kits, and methods described herein provide for no compromise in specificity and provide for a significant increase in sensitivity relative to previously described methods.
    Type: Application
    Filed: October 28, 2011
    Publication date: May 29, 2014
    Applicant: COHESIVE TECHNOLOGIES INC.
    Inventors: Joseph L. Herman, Dayana Argoti
  • Patent number: 8734723
    Abstract: A gas sensor cell using a liquid crystal composite material is provided. The gas sensor cell has recovery capability and can be reused. Upon gas adsorption, the liquid crystal composite material has visually detectable color changes and changes in electrical properties to facilitate the measurement of gas concentration from low to high.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: May 27, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Chin-Kai Chang, Hui-Lung Kuo
  • Publication number: 20140127825
    Abstract: Quantification of vitamin D2, vitamin D3, and the monohydroxy and diihydroxy metabolites of vitamin D2 and vitamin D3, can comprise labeling analytes with mass spectrometry (MS) tagging reagents and performing LC-MSMS analysis of the labeled analytes. The labeled analytes can include a labeled standard and can have distinct retention times on a reversed phase column, as well as distinct masses. Under high energy collisions, reporter groups can be generated. The intensity or the peak area detected for each reporter group can be used for quantitation. In some embodiments, a one-step tagging reagent is used that is a dienophile-containing, labeled m Diels Alder reagent.
    Type: Application
    Filed: December 12, 2013
    Publication date: May 8, 2014
    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
    Inventors: Subhakar Dey, Sasi Pillal, Brian L. Williamson, Subhasish Purkayastha
  • Patent number: 8709816
    Abstract: The present invention relates to a method for diagnosing, and treating renal disease in a patient by having a test performed for detecting or quantifying one or more renal disease markers present in a test blood sample from the patient; and administering treatment to improve renal function. In particular embodiments, the test performed quantifies cis-aconitate, and the patient is identified as having the renal disease when a concentration of cis-aconitate present in the patient's test blood sample is higher than that of a control. Methods of the present invention can allow diagnosis and treatment of patients with early stage renal disease, such as early stage renal failure. Another aspect of the present invention relates to methods for screening for a prophylactic/therapeutic agent for treating renal disease using one or more renal disease markers.
    Type: Grant
    Filed: September 3, 2010
    Date of Patent: April 29, 2014
    Assignees: Tohoku University, Keio University
    Inventors: Takaaki Abe, Tomoyoshi Soga
  • Patent number: 8697450
    Abstract: Described herein are methods for determining an amount of an analyte in a test sample. The methods involve preparing a calibration curve using standard samples containing an isotopically-labeled standard in a biological matrix.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: April 15, 2014
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Blas Cerda, Alex Cherkasskiy
  • Patent number: 8685739
    Abstract: There is provided a method of diagnosing a disease state in a subject. The disease state is caused or effected by pneumococcal infection. The method includes obtaining a biological test sample from the subject. The biological sample includes at least one metabolite selected from the group consisting of citrate, trigonelline, acetylcarnitine, acetone, myo-inositol, 3-hydroxybutyrate, glucose and carnitine. A respective concentration of each one of the at least one metabolite is compared with a predetermined concentration value associated with a corresponding one of the at least one metabolite. The predetermined concentration value is indicative of the disease state. For example, the biological sample includes any one of citrate, trigonelline, acetylcamitine, acetone, myoinositol, 3-hydroxybutyrate, glucose and carnitine. As a further example, the biological samples include any combination of citrate, trigonelline, acetylcamitine, acetone, myo-inositol, 3-hydroxybutyrate, glucose and carnitine.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: April 1, 2014
    Inventors: Carolyn Slupsky, Thomas Marrie
  • Publication number: 20140065717
    Abstract: A method for measuring the concentration of advanced-oxidation active species includes a step of measuring the absorption characteristics of a wavelength region including the wavelength of 195 to 205 nm of a sample and a step of determining the concentration of the advanced-oxidation active species from the aforementioned measured absorption characteristics on the basis of the absorption coefficient of the advanced-oxidation active species in the wavelength region including the wavelength of 195 to 205 nm. The method and the apparatus can measure the concentration of the advanced-oxidation active species directly in line without the need for adding an additive.
    Type: Application
    Filed: January 7, 2013
    Publication date: March 6, 2014
    Applicant: KURASHIKI BOSEKI KABUSHIKI KAISHA
    Inventors: Noboru Higashi, Naomi Kariyama, Yukihiro Ozaki, Yusuke Morisawa, Akifumi Ikehata, Takeyoshi Goto
  • Publication number: 20140051176
    Abstract: The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.
    Type: Application
    Filed: October 25, 2013
    Publication date: February 20, 2014
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel J. Clarke, Richard E Reitz
  • Publication number: 20140030813
    Abstract: System for measuring the hydro carbonate content in minerals, particularly pyrobituminous shale minerals, while they pass through the transport or production system, in such a way as to permit the prior adjustment of the processing conditions of said minerals. The system consists of a set of equipment for the measurement of water content, material density and hydrogen content in the mineral, said equipment being combined in such a way as to create a specific time delay between the measurements, in order for the collected data to be micro processed and the processing conditions to be adjusted in real time, based on the calculated hydro carbonate content.
    Type: Application
    Filed: November 18, 2011
    Publication date: January 30, 2014
    Applicant: PETROLEO BRASILEIRO S.A. - PETROBRAS
    Inventor: Paulo Roberto Pinheiro Amaral
  • Publication number: 20140024130
    Abstract: The invention relates to a chemical breath testing device including a transparent testing tube which cooperates with an outlet piece incorporating a valve and fitted to an inflatable bag. The testing tube is provided with a member for pushing the valve which is formed by the bottom of a cap. The outer sidewall of the cap is resiliently deformable and serves to form an interlocking connection between the testing tube and the outlet piece. The cap is mounted in a mobile manner at the end of the testing tube and carries a cutting blade for cutting a seal closing off the outlet of the testing tube, of which the rim forms a counter-blade.
    Type: Application
    Filed: September 12, 2013
    Publication date: January 23, 2014
    Applicant: CONTRALCO
    Inventors: Antoine MARIN, Eric CONDESSE
  • Publication number: 20140017798
    Abstract: An improved analytical method for analysis of dianhydrogalactitol preparations provides a method for determining the purity of dianhydrogalactitol and detecting impurities in preparations of dianhydrogalactitol, as well as identifying any such impurities. The method employs high performance liquid chromatography (HPLC), in particular, HPLC with evaporative light scattering detection (ELSD); the HPLC can be followed by tandem mass spectroscopy. The method can further comprise the step of performing preparative HPLC collection of at least one specific substance peak present in a preparation of dianhydrogalactitol.
    Type: Application
    Filed: July 2, 2013
    Publication date: January 16, 2014
    Applicant: Del Mar Pharmaceuticals
    Inventor: Xiaoyun Yu
  • Patent number: 8628969
    Abstract: Provided is a method for quantitative analysis of carotenoids such as ?-cryptoxanthin contained in a sample such as citrus fruit or the like which enables simple and accurate quantitative analysis. An internal standard such as lycopene or retinal is used, whereby work is facilitated and an error of a measured value is reduced. Further, a dehydrating agent is added during saponification reaction in the preparation of a sample for analysis, whereby a deviation of a measured value can be reduced.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: January 14, 2014
    Assignee: Suntory Beverage & Food Limited
    Inventor: Naoki Kasajima
  • Publication number: 20140011282
    Abstract: The present invention generally relates to a low temperature plasma probe for desorbing and ionizing at least one analyte in a sample material and methods of use thereof. In one embodiment, the invention generally relates to a low temperature plasma probe including: a housing having a discharge gas inlet port, a probe tip, two electrodes, and a dielectric barrier, in which the two electrodes are separated by the dielectric barrier, in which application of voltage from a power supply generates a low temperature plasma, and in which the low temperature plasma is propelled out of the discharge region by the electric field and/or the discharge gas flow.
    Type: Application
    Filed: August 26, 2013
    Publication date: January 9, 2014
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: Zheng Ouyang, Jason Harper, Nicholas Charipar, Robert Graham Cooks
  • Patent number: 8617898
    Abstract: Quantification of vitamin D2, vitamin D3, and the monohydroxy and diihydroxy metabolites of vitamin D2 and vitamin D3, can comprise labeling analytes with mass spectrometry (MS) tagging reagents and performing LC-MSMS analysis of the labeled analytes. The labeled analytes can include a labeled standard and can have distinct retention times on a reversed phase column, as well as distinct masses. Under high energy collisions, reporter groups can be generated. The intensity or the peak area detected for each reporter group can be used for quantitation. In some embodiments, a one-step tagging reagent is used that is a dienophile-containing, labeled Diels Alder reagent.
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: December 31, 2013
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Subhakar Dey, Sasi K. Pillai, Brian Williamson, Subhasish Purkayastha
  • Publication number: 20130316464
    Abstract: Disclosed is an apparatus for automatically extracting i2,6-diisopropylphenol (Propofol), from a complex sample matrix comprising cellular material, e.g.
    Type: Application
    Filed: October 11, 2011
    Publication date: November 28, 2013
    Inventors: David Michael Pettigrew, Bo Liu, Peter Georg Laitenberger, Stephen Bates
  • Publication number: 20130302781
    Abstract: Disclosed is a method of determining the presence of an analyte of interest by means of a detection of a reaction product between the analyte of interest and a reactant, the method comprising extracting the analyte of interest from a complex sample matrix; transferring the analyte of interest to an initial reaction mixture; performing a background measurement on the initial reaction mixture comprising at most a negligible concentration of the reaction product, wherein the reaction conditions present in said initial reaction mixture at least reduce the reaction rate of the formation of the reaction product such that the background measurement can be performed without a measurable change in said negligible concentration; altering the reaction conditions in the initial reaction mixture to accelerate said reaction rate; continuing said reaction until the concentration of the reaction product has stabilized; performing a second measurement on the resultant reaction mixture to obtain a signal correlated to said con
    Type: Application
    Filed: October 11, 2011
    Publication date: November 14, 2013
    Applicant: Sphere Medical Limited
    Inventors: David Michael Pettigrew, Peter Georg Laitenberger, Bo Liu
  • Publication number: 20130295679
    Abstract: A method of predicting a SGA infant in a patient at a pre-symptomatic gestational stage is described. The method comprises a step of assaying a biological sample from the patient for an abundance of a plurality of metabolite biomarkers selected from the 19 metabolite biomarkers of Table IV, correlating the abundance of the plurality of metabolite biomarkers with a metabolite fingerprint of SGA shown in Table IV, and predicting SGA based on the level of correlation between the abundance of the plurality of metabolite biomarkers and the metabolite fingerprint of Table IV.
    Type: Application
    Filed: November 16, 2011
    Publication date: November 7, 2013
    Applicant: UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
    Inventors: Louise Kenny, Philip Baker
  • Publication number: 20130266589
    Abstract: Desmosterol alone, the combination of desmosterol and amyloid beta, the combination of desmosterol and gelsolin and the combination of desmosterol, amyloid beta and gelsolin can be used as in-blood biomarkers for Alzheimer's disease or mild cognitive impairment. A method for evaluating the effect of a candidate for a therapeutic agent to treat Alzheimer's disease or mild cognitive impairment, a method for aiding the diagnosis of Alzheimer's disease or mild cognitive impairment, and a method for diagnosing Alzheimer's disease or mild cognitive impairment are provided in which the biomarkers are used.
    Type: Application
    Filed: June 23, 2011
    Publication date: October 10, 2013
    Applicant: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Yoshiaki Sato, Ken Aoshima, Francois Bernier
  • Publication number: 20130252342
    Abstract: The invention describes a method of determining the amount of an analyte in a sample wherein the analyte comprises one or more vitamin D metabolites; comprising the steps of; contacting the analyte with an alkylamine to form an alkylamine adduct; subjecting the adduct to a MS technique to determine the amount of the adduct; and calculating the amount of the analyte equivalent to the amount of the adduct.
    Type: Application
    Filed: March 29, 2011
    Publication date: September 26, 2013
    Applicant: MICROMASS UK LIMITED
    Inventors: Lisa J. Calton, Billy J. Molloy
  • Publication number: 20130244335
    Abstract: Methods for determining the amount of vitamin D compounds in a sample are provided. The methods can employ LC-MS/MS techniques and optionally the use of deuterated internal standards. Methods for diagnosing vitamin D deficiencies are also provided.
    Type: Application
    Filed: May 3, 2013
    Publication date: September 19, 2013
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Ravinder J. Singh, Robert L. Taylor, Stefan K.G. Grebe
  • Publication number: 20130244269
    Abstract: Described herein are methods for determining an amount of an analyte in a test sample. The methods involve preparing a calibration curve using standard samples containing an isotopically-labeled standard in a biological matrix.
    Type: Application
    Filed: March 5, 2013
    Publication date: September 19, 2013
    Applicant: PERKINELMER HEALTH SCIENCES, INC.
    Inventors: Blas Cerda, Alex Cherkasskiy
  • Publication number: 20130236979
    Abstract: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
    Type: Application
    Filed: April 26, 2013
    Publication date: September 12, 2013
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Nigel J. Clarke, Brett Holmquist, Gloria Kwang-Ja Lee, Richard E. Reitz
  • Publication number: 20130224783
    Abstract: The invention relates to a method for analysis of liposoluble vitamins of biological materials. It is proposed to perform reagent storage, sample application and conducting of the measuring in one reaction vessel and to correct interfering ingredients during the photometric evaluation.
    Type: Application
    Filed: September 21, 2011
    Publication date: August 29, 2013
    Applicant: BAPaT GmbH
    Inventors: Florian J. Schweigert, Ralf Mothes
  • Patent number: 8518707
    Abstract: A method of monitoring breakthrough of an adsorbent bed consisting for example of ion-exchange resins, used during a stage of purification of an ester stream containing glycerin, obtained for example in a vegetable or animal oil and aliphatic monoalcohol transesterification process, permits the instantaneous detection of the presence of glycerol (glycerin) in the ester stream by arranging a turbidimeter at the adsorbent bed outlet.
    Type: Grant
    Filed: July 20, 2009
    Date of Patent: August 27, 2013
    Assignee: IFP Energies Novelles
    Inventors: Abdelhakim Koudil, Karin Barthelet, Laurent Bournay
  • Publication number: 20130217136
    Abstract: An improved qualitative or semi-quantitative diagnostic test for low levels of any analyte, such as hCG, in a biological sample, such as urine. The test comprises of a test device containing reagents for the detection of the monitored analyte and an electronic reader that measures color development at a detection area of the device. The color development is converted to an electronic or digital signal. Improvements were made to the detection process to optimize the detection of a valid fluid front, increase the detection limit without compromising the reliability and accuracy of the test system, and improve the determination of test result validity.
    Type: Application
    Filed: February 22, 2012
    Publication date: August 22, 2013
    Applicant: CHURCH & DWIGHT CO., INC.
    Inventors: Albert R. Nazareth, Andy Sturman, Benedict Zin
  • Publication number: 20130217036
    Abstract: The present invention relates in particular to methods of detecting predisposition to or diagnosis and/or prognosis of Charcot-Marie-Tooth (CMT) and related disorders. More specifically, the invention relates to development, validation and application of new biomarkers, which can be used for detecting the presence or risk of CMT disease and related disorders. In particular, the present invention relates to metabolite, lipid, carbohydrate and proteinaceous biomarkers that can be measured in biological body fluids and easily available extracts of biopsies, which can be used to aid in the detection, prediction of drug treatment and follow up of this treatment of neurodegenerative disorders, including CMT disease. The present invention also relates to methods for identification of CMT disease subtypes, assessing the responsiveness to the treatments and the efficacy of treatments in subjects having CMT or a related disorder.
    Type: Application
    Filed: November 19, 2010
    Publication date: August 22, 2013
    Applicant: Pharnext
    Inventors: Daniel Cohen, Ilya Chumakov, Oxana Guerassimenko, Serguei Nabirochkin
  • Patent number: 8513023
    Abstract: A method of determining the functional activity of the MRP2 and/or MRP3 efflux pathway of a human or animal subject was disclosed. The method comprises (i) determining the level of a bile acid derivative in the blood of said human or animal subject at a predetermined time interval after introducing an amount of the bile acid derivative into the subject, and (ii) using the determination obtained in step (i) to indicate the functional activity of the MRP2 and/or MRP3 efflux pathway of the subject.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: August 20, 2013
    Assignee: Norgine BV
    Inventors: Hans-Jürgen Gruss, Ronald Oude Elferink, Dirk De Waart, Bruno Stieger