With Reagent In Absorbent Or Bibulous Substrate Patents (Class 436/169)
  • Patent number: 10328427
    Abstract: The present invention provides an assay device for detecting an analyte in a fluid sample, comprising: a sample receiving member (1), which is fluidically connected to at least two components (2, 3) defining an assay flow path, at least one of which is a detection member (3) comprising an analyte detection zone (31); and a sample detection element (13) adapted to detect fluid at a particular point along the assay flow path. The present invention also provides the use of the assay device of the invention for indicating sample sufficiency when the assay device is exposed to a fluid sample and for indicating to a user after sampling that the device has failed due to insufficient sampling, and a method of alerting a user to the fact that a sufficient sample has been applied to an assay device of the invention.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: June 25, 2019
    Inventors: Kieran Andrew Lehane, Steven Hart
  • Patent number: 10024864
    Abstract: Gold nanoparticles functionalized with thiolated, bidentate Schiff base ligands. The Schiff base ligands form a ligand monolayer surrounding and binding to the surface of a gold nanoparticle core through Au—S linkages. The functionalized gold nanoparticle composites have a spherical shape, an average diameter of 7-15 nm and a narrow particle size distribution. Methods of assessing these functionalized gold nanoparticle composites as fluorescent probes in Fe(III) chemosensing applications, methods of preparing the functionalized gold nanoparticle composites and methods of detecting Fe(III) ions with the same are also provided.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: July 17, 2018
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Mohammed Nasiruzzaman Shaikh, Aasif Helal, Abiola Azeez Jimoh
  • Patent number: 10001443
    Abstract: A method of identifying the presence of heroin in an impure heroin composition which contains heroin and at least one fluorescent contaminant which interferes with a Raman signal from the heroin. The method may include contacting the mixture with a solvent such as an alcohol, then contacting the resulting alcohol composition with a SERS surface. The surface may then be exposed to laser light from a hand-held Raman spectrometer to detect a Raman signal from the heroin. An apparatus for performing the method is also provided.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: June 19, 2018
    Assignee: Thermo Scientific Portable Analytical Instruments Inc.
    Inventors: Craig Morris Gardner, Michael Derek Hargreaves, Peidong Wang, Yu Shen
  • Patent number: 9968931
    Abstract: This invention provides lateral flow filters with pore size gradients and with features to prevent peripheral flows around the filter. The filters can be laminated composites of two or more planar filter layers. Cartridges employing the filters can include a filtration chamber configured to retain the lateral flow filters including a port for sample application and a capillary channel for filtrate egress. The fluid egress port can be positioned to receive filtrate from one filter layer but not another.
    Type: Grant
    Filed: October 15, 2008
    Date of Patent: May 15, 2018
    Inventors: Nan Zhang, Zhiliang Wan
  • Patent number: 9901922
    Abstract: An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface; and an outlet for driving out the sample fluid. The device further comprises a third layer comprising an adhesive material such as a patterned adhesive material, and a flow path, wherein the third layer is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer and the outlet is in contact with the flow path of the third layer for allowing the sample fluid out from the integrated device.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: February 27, 2018
    Inventors: Ralf Lenigk, Erin Jean Finehout, Xuefeng Wang
  • Patent number: 9786061
    Abstract: A specimen analysis system includes at least one processor to receive a set of image information that represents an image of at least a specimen validity portion of the specimen test article which includes at least one optical specimen validity marker, the color of which indicates the validity of the specimen; determine a set of color component values for one or more of a plurality of pixels of the image that are representative of the specimen validity portion of the specimen test article, the set of color component values including at least three color component values; and assess at least one specimen validity characteristic of the specimen based at least in part on each color component value of the determined set of color component values for the one or more of the plurality of pixels of the image.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: October 10, 2017
    Assignee: GENPRIME, INC.
    Inventors: Michael Arthur Russell, Claire Elizabeth Norton, Darby Dawn McLean, Jason Buck Somes
  • Patent number: 9658181
    Abstract: The present invention pertains to a hemolysis sensor, a hemolysis sensor system and methods of utilizing the hemolysis sensor or hemolysis sensor system to monitor or detect hemolysis in a sample, such as a whole blood sample, a plasma sample, a serum sample or hemolyzed blood. The hemolysis sensor responds to extracellular hemoglobin levels, for example, extracellular hemoglobin in a whole blood sample as a method for detecting hemolysis in whole blood.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: May 23, 2017
    Assignee: Instrumentation Laboratory Company
    Inventors: Shankar Balasubramanian, Paul D'Orazio
  • Patent number: 9606112
    Abstract: There is provided an assay device comprising a lid and a base, said base comprising, a sample addition zone, a reaction zone and an absorbing zone, said components being in fluid connection and being part of a fluid passage leading from the sample addition zone to the absorbing zone, wherein: (a) a sample addition well is integrated in the lid, (b) the absorbing zone consists of an area on an non-porous substrate, having substantially perpendicular projections, said projections defining a volume, which together with the volume of the fluid passage defines the sample volume subjected to the assay, and (c) at least one filter is between the sample addition well and the sample addition zone. There is further provided methods for handling samples.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: March 28, 2017
    Assignee: JOHNSON & JOHNSON AB
    Inventors: Per Ove Öhman, Ib Mendel-Hartvig
  • Patent number: 9547899
    Abstract: A system for hemolysis detection, where the system generally includes—individually or in combination—a containment apparatus for holding the blood sample and a software application for analyzing the blood sample. The containment apparatus houses the sample therein, and blocks out any light from penetrating the apparatus and reflecting off of the sample. In conjunction, the software application uses camera color for processing the color of the sample to determine the hemoglobin level in plasma based on the color.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: January 17, 2017
    Assignee: University of South Florida
    Inventor: Anna Pyayt
  • Patent number: 9423398
    Abstract: In accordance with exemplary embodiments, apparatus and method for biologic sample rapid collection and recovery device, and convenient storage are provided. An exemplary embodiment includes an apparatus comprising a lateral flow technology device including at least a membrane configured to bind an analyte from a sample that flows through the lateral flow technology device, in which a selected portion of the membrane bound to the analyte when placed directly in an analysis system does not substantially inhibit analysis of the analyte. An elution protocol is not required to extract the analyte bound from the selected portion before placed directly in the analysis system.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: August 23, 2016
    Assignee: The Board of Regents for Oklahoma State University
    Inventor: Francisco Manuel Ochoa Corona
  • Patent number: 9380977
    Abstract: A sensor for indirect estimation of breast milk intake by an infant, the sensor comprising: a housing configured to be externally attached to an incontinence product worn by a subject, said housing comprising: a light-emitting diode (LED) configured to illuminate the incontinence product; a photodetector configured to output an indication of the amount of light reflected from the incontinence product; and an integrated circuit configured to: (a) receive the indication from said photodetector, (b) compute, based on the indication, an amount of urine secreted by the subject into the incontinence product, and (c) estimate the amount of breast milk intake by the infant based on the amount of urine secreted by the subject into the incontinence product.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: July 5, 2016
    Assignee: DIGISENSE LTD.
    Inventor: Eyall Abir
  • Patent number: 9241655
    Abstract: A measuring device for measuring a physiological parameter of an aspirate. The device includes a sensor element for measuring the physiological parameter, a connection port for fluid communication with a medical tube, a collection tube for aspirating and/or collecting the aspirate, a housing, wherein the sensor element is mounted within the housing and a communication passage enabling the aspirate to enter the housing from the collection tube such that the sensor element can measure the physiological parameter. Further, a method for measuring the parameter is disclosed.
    Type: Grant
    Filed: February 1, 2012
    Date of Patent: January 26, 2016
    Assignee: Covidien LP
    Inventors: Ciara Deighan, Paul J. Daly, Alan Fitzgerald
  • Patent number: 9239280
    Abstract: Although a more accurate estimate of a person's risk of cardiovascular disease can be made on the basis of the number of lipoprotein particles per unit volume in the person's blood, current methods all rely on measuring the mass of lipoprotein cholesterol per unit volume. It has been discovered that a rapid and accurate lipoprotein particle count can be obtained by photometry. A method and apparatus are provided for measuring the number of lipoprotein particles in a sample using photometry.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: January 19, 2016
    Assignee: ATHEROTECH, INC.
    Inventor: Krishnaji R Kulkarni
  • Patent number: 9121857
    Abstract: A membrane-based assay device, methods and kits for determining the presence or quantity of an analyte in a test sample are provided. The immunochromatographic device comprises a membrane having a capture antibody bound thereto at a test zone, wherein the capture antibody is capable of binding with an analyte, in particular a Z-AAT protein present in a sample from a PiZ gene carrier.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: September 1, 2015
    Assignee: Grifols Therapeutics Inc.
    Inventor: Marco Grebe
  • Patent number: 9034657
    Abstract: A two step lateral flow assay method for identifying IgE antibodies in a sample comprises applying a sample to a sample port of a device, wherein the device is adapted to deliver the sample to a lateral flow matrix having a plurality of IgE antigen species immobilized at respective positions at a first location; allowing the sample to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species to a second location downstream of the first location; and, after a predetermined period of time, applying liquid buffer to the lateral flow matrix to mobilize labeled reagent which is adapted to bind anti-IgE antibody and which is dried on the lateral flow matrix at a location upstream of the sample port delivery of the sample to the lateral flow matrix, and allowing labeled reagent mobilized by the liquid buffer to travel along the lateral flow matrix through the immobilized plurality of IgE antigen species and bind with any IgE antibody bound to the immobilized IgE antigen species, a
    Type: Grant
    Filed: December 8, 2010
    Date of Patent: May 19, 2015
    Assignee: Phadia AB
    Inventors: Gerd Rundström, Per Matsson, Paul Christopher
  • Patent number: 9028756
    Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: May 12, 2015
    Assignee: Sysmex Corporation
    Inventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
  • Patent number: 9028772
    Abstract: A method may involve forming one or more photoresist layers over a sensor located on a structure, such that the sensor is covered by the one or more photoresist layers. The sensor is configured to detect an analyte. The method may involve forming a first polymer layer. Further, the method may involve positioning the structure on the first polymer layer. Still further, the method may involve forming a second polymer layer over the first polymer layer and the structure, such that the structure is fully enclosed by the first polymer layer, the second polymer layer, and the one or more photoresist layers. The method may also involve removing the one or more photoresist layers to form a channel through the second polymer layer, wherein the sensor is configured to receive the analyte via the channel.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: May 12, 2015
    Assignee: Google Inc.
    Inventors: Huanfen Yao, Jeffrey George Linhardt, Babak Parviz
  • Patent number: 9012234
    Abstract: A mobile water analyzing system for determining an analyte in a water sample includes a basic unit and a test element configured to be inserted into the basic unit. The test element includes a sample line with an inlet opening configured to receive the water sample, a measuring section forming a measuring track and configured to allow the determination of an analyte, a pump opening, and a key reagent disposed inside the sample line. The basic unit includes a test element receptacle configured to hold the inserted test element, an analyzer with an analyzer measuring track formed by the measuring section, and a pump actuator cooperatively connected with the pump opening.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: April 21, 2015
    Assignee: Hach Lange GmbH
    Inventors: Ulrich Lundgreen, Aria Farjam, Rolf Uthemann, Andreas Mitreiter, Isabel Huenig, Markus Lenhard, Rainer Froemel, Hans-Joachim Kumpch
  • Publication number: 20150099306
    Abstract: A reading device for reading and analyzing a test cassette having an identification code includes a reading unit, used for reading the identification code marked by the test cassette and carrying out interpretation on a plurality of test lines of the test cassette; an operating unit, used for operating the reading device; a processing unit, used for interpreting a test result with the identification code and the test lines; and a display unit, used for displaying the test result of the test cassette.
    Type: Application
    Filed: April 7, 2014
    Publication date: April 9, 2015
    Inventor: HUI-CHI KU
  • Patent number: 8999725
    Abstract: In one embodiment of the present application, a stimulus-responsive gel is disclosed with optical characteristic molecule introduced therein that is capable of easily and securely converting a volume change responding to external stimulus to optical data being easy to handle in the construction of sensor system; an external stimulus measuring apparatus making use of the same; and a method of measuring external stimulus therewith.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: April 7, 2015
    Assignee: Japan Science and Technology Agency
    Inventors: Takashi Miyata, Tadashi Uragami, Kaori Okawa
  • Patent number: 8999723
    Abstract: A reliable, low cost device for determining when dangerous levels of hydrogen gas have been generated in a transformer is disclosed. The hydrogen indicator is defined by a module assembly that threads into either the headspace or into the oil-filled body of a transformer. The module has an open interior that contains a film that incorporates a hydrogen-sensitive chemochromic indicator. The indicator film is visible through a lens. When the film has been exposed to hydrogen, chemical changes in the chemochromic indicator cause the film to change color—the color change is immediately visible through the lens.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: April 7, 2015
    Assignee: Serveron Corporation
    Inventor: Steven Mahoney
  • Patent number: 8999728
    Abstract: The invention comprises a device for detecting an analyte in a liquid sample deposited on a first portion of the device for transport to a second portion of the device that is in fluid contact with the first portion. In specific embodiments, the device is a pregnancy test device, which detects human chorionic gonadotropin (hCG) as an indicator of pregnancy. Devices with improved clinical sensitivity are provided which are capable of detecting all clinically relevant hCG isoforms.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: April 7, 2015
    Assignee: Church & Dwight Co., Inc.
    Inventors: Albert R. Nazareth, Shang Li
  • Patent number: 8987001
    Abstract: The present invention relates to an oxygen indicator in which the presence or absence of oxygen is made visible by a color change, and to the use of such oxygen indicator for monitoring parenteral and enteral dosage forms.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: March 24, 2015
    Assignee: B. Braun Melsungen AG
    Inventors: Volker Krueger, Rolf Beck
  • Patent number: 8986625
    Abstract: A method for sampling a sulphur-containing solid product including supplying a gas flow comprising hydrogen sulphide, bringing the gas flow into contact with a solid reagent and reacting the solid reagent with the hydrogen sulphide contained in the gas flow, the reaction fixing the sulphur of the hydrogen sulphide by forming a sulphur-containing solid product which is different in color from the solid reagent, and recovering the sulphur-containing solid product. The invention also relates to a device suitable for the implementation of this method.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: March 24, 2015
    Assignee: Total S.A.
    Inventors: Daniel Dessort, Robert Le Van Loï, Nadine Loubere
  • Publication number: 20150079693
    Abstract: A product and method for the detection of one or more analytes in a collected sample employs capillary action in a sample card containing a sample substrate, at least one test capsule and an absorbent pad. The absorbent pad absorbs the contents of the test capsule and delivers the same to the sample substrate, with the contents of the test capsule chemically reacting with at least one detection reagent to establish an optical indicator for the analyte(s). The sample card can be automatically tested within a reader device which supplies one or more light sources, records and processes an optical signal produced by the chemical reaction, and outputs a test result.
    Type: Application
    Filed: April 3, 2013
    Publication date: March 19, 2015
    Applicant: REDXDEFENSE, LLC
    Inventors: Arman Ghodousi, Sarah Josepha Toal, Gregory Scott Ericksen, Daniel Douglas Montgomery, Thomas Emory McVeigh, Jacek Kotowicz
  • Patent number: 8968677
    Abstract: An improved apparatus and method for dispersion of a labeling conjugate in a diagnostic assay, the result being a one-step assay. By eliminating a conjugate pad as in conventional lateral diagnostic devices, and forming a frazil ice pellicle (FIP), rehydration and flow are improved resulting in better reproducibility, improved sensitivity, and reduced costs of individual assay devices. The formation of a frazil ice film formed on a super cooled surface of a sample receiving means simplifies assay assembly. Lyophilization of the FIP improves the release of a sample/analyte/label matrix into a macro channel as in a direct flow assay, while at the same time allowing reagents to mix and flow, thereby optimizing the assay performance. The reagents of the conjugate and the formation of the FIP stabilize the conjugate proteins and provide extended shelf life to the diagnostic assay device.
    Type: Grant
    Filed: January 22, 2013
    Date of Patent: March 3, 2015
    Assignee: Quantum Design International, Inc.
    Inventors: Ronald T. LaBorde, Nicholas J. Neild
  • Patent number: 8969097
    Abstract: Disclosed are devices, arrangements and methods for quantifying the concentration of an analyte present in bodily fluid, including: an assay pad having at least one chemical reagent capable of producing a detectable signal in the form of a reaction spot upon reaction with the analyte; a light source; a detector array; a processor; and a memory in communication with the processor, the memory comprising: (a) at least one value indicative of one or more of: (i) the level of hematocrit contained in the sample; (ii) the volume of the sample applied to the assay pad; or (iii) imperfections present in the reaction spot; and (b) at least one algorithm for calculating the concentration of the analyte contained in the sample.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: March 3, 2015
    Assignee: Intuity Medical, Inc.
    Inventors: Jeffrey L. Emery, Carole R. Stivers
  • Patent number: 8962341
    Abstract: An assay system designed to detect a protein biomarker in urine that is diagnostic for interstitial cystitis (IC). The presence of a 9 amino acid glycopeptide, antiproliferative factor (APF), in urine is unique to patients with IC. Urine samples from patients who exhibit symptoms consistent with IC are added to the assay system. Binding of APF to the cytoskeletal associated protein 4 (CKAP4) is positive for the presence of APF in urine and diagnostic for IC. The diagnostic system is a significant and surprising advance in diagnosis of IC and has commercial applications relevant to women and men who suffer from symptoms consistent with IC.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: February 24, 2015
    Assignees: The Commonwealth Medical College, University of Florida Research Foundation, Inc.
    Inventors: David Alan Zacharias, Sonia Lobo Planey
  • Patent number: 8951472
    Abstract: A fluorimetric system, apparatus and method are disclosed to measure an analyte concentration in a sample. A sensor reagent housing is also disclosed which comprises a channel and a porous medium having an analysis chemistry reagent, such as a nucleic acid analysis chemistry reagent. The apparatus and system are portable for field use, with an apparatus housing having a size adapted to fit into a user's hand. An apparatus also includes a sensing chamber and cover, a user interface, a light source, a photomultiplier tube, an amplifier, an A/D converter, a memory, and a processor. In various embodiments, the processor performs a data fitting, determines a sample reaction rate parameter, and determines the analyte concentration from a comparison of the sample reaction rate parameter with stored calibration data. The processor may also generate the calibration data and site-specific offset factors, and modify the calibration data using an offset factor.
    Type: Grant
    Filed: July 19, 2010
    Date of Patent: February 10, 2015
    Assignee: ANDalyze, Inc.
    Inventors: David G. Kellner, Debapriya Mazumdar
  • Patent number: 8945939
    Abstract: The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: February 3, 2015
    Assignee: Ecolab USA Inc.
    Inventors: Amy M. Tseng, Brian V. Jenkins, Robert Mack
  • Kit
    Patent number: 8940248
    Abstract: A kit comprising a carrier and vessels arranged on the carrier, wherein different reagents are contained in different vessels, the vessels are arranged with an openable closing device on top of the carrier, the carrier has a footprint on the bottom side for being placed on a base, and the carrier has bottom positioning means for being positioned on at least one workplace of an automated laboratory system for microtiter plates according to the SBS standard.
    Type: Grant
    Filed: April 29, 2013
    Date of Patent: January 27, 2015
    Assignee: Eppendorf AG
    Inventors: Judith Lucke, Jens-Peter Kroog, Helmut Knofe
  • Patent number: 8940246
    Abstract: A system for diagnostic testing may include a meter for performing a diagnostic test on a sample applied to a test media, the meter having a housing and an interface for receiving a signal representing coding information, and a container configured to contain test media compatible with the meter, the container having a coding element associated therewith. Additionally, the system may provide a mechanism for removing the meter from an interconnected test container and reattaching it to a new container using on-container coding methods that can recalibrate the meter for the new container of test strips.
    Type: Grant
    Filed: November 1, 2007
    Date of Patent: January 27, 2015
    Assignee: Nipro Diagnostics, Inc.
    Inventors: Gary T. Neel, Brent E. Modzelewski, George R. Rounds, Carlos Oti, Allan Javier Caban, Jeffrey Akins
  • Patent number: 8940237
    Abstract: An optic light guide test sensor comprises a light guide, a reagent-coated membrane, and a mesh layer. The reagent-coated membrane and the mesh layer are attached to the light guide at an output end of the light guide. The light guide test sensor is adapted to be used to test the level of an analyte in a biological fluid sample when used with a readhead. A method of manufacturing the light guide test sensor involves providing a plurality of light guides, providing a strip of reagent-coated membrane, and providing a strip of mesh layer. The reagent-coated membrane and mesh layer are attached to the light guides by ultrasonic welding. The reagent-coated membrane and mesh layer may also be attached to the light guides by adhesive.
    Type: Grant
    Filed: January 22, 2013
    Date of Patent: January 27, 2015
    Assignee: Bayer HealthCare LLC
    Inventors: Jeffery S. Reynolds, Steven C. Charlton, Sung-Kwon Jung, Suny J. George
  • Patent number: 8932874
    Abstract: The invention is directed towards methods and compositions for identifying the amount of ammonium acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of ammonium acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of ammonium acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the ammonium acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: January 13, 2015
    Assignee: Nalco Company
    Inventors: Amy M. Tseng, Brian V. Jenkins, Robert M. Mack
  • Patent number: 8935007
    Abstract: An analyte testing device is provided for use with a mobile processing device having a camera with a lens, a processor for processing an image captured by the lens. The analyte testing device comprises a casing and a test strip positioner. The test strip positioner positions an analyte containing test strip adjacent to the camera lens to permit the camera to capture an image of the analyte containing test strip. A light source is disposed within the casing. The light source is positioned within the casing to illuminate the analyte containing test strip to facilitate the capture of the image of the test strip. Software is contained within the mobile processing device for performing a quantitative analysis of at least one analyte from the captured image, and providing an output of the results of the quantitative analysis.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: January 13, 2015
    Assignee: 4a medicom GmbH
    Inventors: Hans G. Kloepfer, Thomas Kloepfer, Jason Heim, Reinhard Hafellner
  • Publication number: 20150004594
    Abstract: The present invention provides a semi-quantitative lateral flow assay device and method for generating semi-quantitative data from a lateral flow assay. The device comprises a thin, porous hydrophilic substrate wherein the substrate includes a star-shaped or other geometry taken in plan view having a liquid sample-receiving central region and multiple arms that extend or radiate out from the central region. Each arm includes a reaction zone formed by the presence of an analyte-capturing agent wherein the reaction zone of each arm is located at a different distance from the central region such that the analyte in the sample is captured accumulates in different quantities at at least some of the reaction zones of the arms in a manner that can be analyzed to yield semi-quantitative data from lateral flow assays.
    Type: Application
    Filed: September 11, 2014
    Publication date: January 1, 2015
    Inventor: Scott S. Sibbett
  • Patent number: 8920725
    Abstract: The present invention is an improved apparatus for sample analysis. The apparatus employs an assay component containing a membrane having one or a plurality of analyte-specific binding agents attached thereto, a means for absorbing liquid, and a piston means for drawing analytes through said membrane into said means for absorbing liquid. The apparatus is configured to be portable and provide a detector for detecting binding of an analyte to an analyte-specific binding agent, a plurality of data acquisition components, and a computer for integrating, analyzing and storing the detected analyte specific binding and acquired data.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: December 30, 2014
    Assignee: Montecito Bio-Sciences, Ltd.
    Inventors: Edward W. Withrow, III, Jorn Gorlach
  • Patent number: 8920746
    Abstract: The present invention relates to devices and systems for detecting the existence of oral conditions.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: December 30, 2014
    Assignee: Colgate-Palmolive Company
    Inventors: Douglas Hohlbein, Elizabeth Gittens, Harsh M. Trivedi, Sharon Kennedy, Madhusudan Patel, Deborah Peru
  • Patent number: 8916110
    Abstract: A device and a process are proposed for separating constituents of a sample fluid, wherein the sample fluid is supplied by capillary force to a receiving region (7) for metering, stopping or delaying the sample fluid and the sample fluid is pre-treated with a soluble chemical (13) in the receiving region (7) before the sample fluid is supplied to a separating device (5) for separating off constituents of the sample fluid.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: December 23, 2014
    Assignee: Boehringer Ingelheim Microparts GmbH
    Inventors: Tobias Rodenfels, Gert Blankenstein
  • Patent number: 8911681
    Abstract: A wetness indicator material may be used on a substrate to form a wetness sensor. The sensor may show either the presence or absence of an aqueous-based fluid or water-containing medium, such as vaginal fluid or urine in a personal hygiene article. The wetness sensor may be incorporated into the article. The wetness indicator material includes a standard colorant that does not change color when wetted. The standard colorant increases the range of hues exhibited by the wetness indicator material.
    Type: Grant
    Filed: September 12, 2011
    Date of Patent: December 16, 2014
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Xuedong Song, Karen Meloy Goeders, Ning Wei
  • Patent number: 8901366
    Abstract: In accordance with one embodiment of the present disclosure, a method for quantitatively or semi-quantitatively determining the volume of a test sample of urine is provided. The method includes contacting the test sample with a fluidic medium of a lateral flow device having a volume indicator disposed thereon and determining the volume of urine in the test sample based on the distance traveled by the volume indicator along the fluidic medium, the distance traveled by the volume indicator corresponding to the volume of urine in the test sample.
    Type: Grant
    Filed: December 14, 2007
    Date of Patent: December 2, 2014
    Assignee: Kimberly Clark Worldwide, Inc.
    Inventors: Xuedong Song, RameshBabu Boga, Ning Wei
  • Patent number: 8900881
    Abstract: The present invention relates to a quantitative assay device and a method for the determination of an analyte, based on a test strip, which contains a porous test membrane allowing for capillary flow of the analyte and complexes of the analyte, a porous upstream membrane in fluid connection with the test membrane and a porous downstream membrane in fluid connection with the test membrane, wherein the test membrane contains two bands having deposited on there high and low concentrations of different calibrator agents and a test band capable of reacting with conjugated analyte complexes giving rise to a measurable signal.
    Type: Grant
    Filed: September 12, 2011
    Date of Patent: December 2, 2014
    Inventor: Jin Po Lee
  • Publication number: 20140329235
    Abstract: A sensor comprises a sensor housing, having a channel; a porous substrate, in the channel; an analysis chemistry reagent, on the porous substrate; and a nozzle, in fluid connection with the channel. The porous substrate fills a cross section of the channel, and the cross-sectional area of the channel at the porous substrate is greater than the cross-sectional area at the nozzle.
    Type: Application
    Filed: July 16, 2014
    Publication date: November 6, 2014
    Inventors: Debapriya Mazumdar, David G. Kellner
  • Patent number: 8877515
    Abstract: It is an object of the present invention to provide a measurement kit for developing a first developing solution and a second developing solution from different directions to suppress background noise, and an immunochromatography kit. The present invention provides a measurement kit, which comprises a first developing member for supplying a first developing solution and a second developing member for supplying a second developing solution, wherein the developing direction of the first developing solution is allowed to intersect with the developing direction of the second developing solution, so that development is carried out by developing the first and second developing solutions in different developing directions, and a water absorbent portion is established on the downstream of each of the developing directions.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: November 4, 2014
    Assignee: FUJIFILM Corporation
    Inventors: Hiroyuki Chiku, Junichi Katada, Hideyuki Karaki, Hiroki Terada
  • Publication number: 20140323322
    Abstract: A chemical sensor comprising: a hydrogel layer, comprising one or more molecular recognition agents and a 2DPC self-assembling array; and a mirror layer. A method for analyzing a sample or bodily fluid, comprising: obtaining a sample or bodily fluid; placing an amount of the sample or bodily fluid onto a chemical sensor, comprising: a hydrogel layer, comprising a molecular recognition agent and a 2DPC self-assembling array; a tethering hydrogel layer; a mirror layer; and a membrane filter layer, allowing the bodily fluid to interact with the hydrogel layer; and allowing ambient or artificial light to pass through the hydrogel layer onto the mirror layer and observing a change in diffraction versus a control.
    Type: Application
    Filed: October 4, 2012
    Publication date: October 30, 2014
    Inventor: Sanford A. Asher
  • Patent number: 8865454
    Abstract: The invention relates to a flow through system for quantifying a target component in a liquid. The flow through system comprises a flow-through device comprising a flow path comprising a marker section, a capture section downstream to said marker section, and at least two quantification sections. The marker section comprises a non-immobilized marker. The capture section comprises a capture zone with an immobilized capture agent, and the at least two quantification sections comprise a pre-capture quantification section placed downstream to the marker section and up stream to the capture section, and a post-capture quantification section placed downstream to the capture section. The system further comprises a quantification unit for each of said quantification sections. The quantification unit(s) being arranged to quantify marker containing components and/or particles passing through said respective quantification sections.
    Type: Grant
    Filed: March 17, 2008
    Date of Patent: October 21, 2014
    Assignee: Scandinavian Micro Biodevices APS
    Inventor: Jacques Jonsmann
  • Patent number: 8865089
    Abstract: Described here are systems, devices, cartridges, methods, and kits for detecting or quantifying at least two different analytes using at least two different techniques, in a single sample. The cartridges typically comprise at least two test sites and the location of at least one test site is not dependent on a corresponding measurement device. The systems generally comprise a device, memory, and a processing module. The device comprises a light source, an array detector, and a port configured to accept at least a portion of a cartridge. The processing module is configured to perform an image analysis of the cartridge. The methods comprise the steps of acquiring calibration information, acquiring an image of the cartridge, performing an image analysis, and cycling through specific detection or quantification techniques corresponding to the techniques required by the test sites. Computer readable media are also described.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: October 21, 2014
    Assignee: Polymer Technology Systems, Inc.
    Inventors: Joel M. Blatt, Carole R. Stivers
  • Patent number: 8846319
    Abstract: The present invention discloses analyte detection devices for detecting one or more analytes present in test samples, especially biological samples. In particular, the devices of the invention are lateral flow assay devices comprising immobilized metal nanoparticle conjugates as the detection means. Methods of using the devices and kits comprising the devices are also described.
    Type: Grant
    Filed: December 3, 2009
    Date of Patent: September 30, 2014
    Assignee: Abaxis, Inc.
    Inventors: Rajesh K. Mehra, Kenneth P. Aron
  • Patent number: 8841131
    Abstract: A cholesterol-level measuring apparatus including a portable body having a cholesterol level detecting means for identifying a cholesterol level in a blood sample, and a display screen communicatively coupled to the cholesterol level detecting means for illustrating a learned cholesterol level in the blood sample. Notably, the cholesterol level detecting means includes a disposable test strip having a color-changing reactive reagent that changes color in response to the learned cholesterol level in the blood sample.
    Type: Grant
    Filed: October 9, 2012
    Date of Patent: September 23, 2014
    Inventor: Ifeanyi Nzeribe
  • Patent number: 8835182
    Abstract: The present invention provides an immunochromatographic device, which contains the following (a) and (b): (a) a first device part holding a first insoluble carrier used for developing a complex formed with an analyte and a labeling substance comprising a metal labeled with a first binding substance that can bind to the analyte and capturing the analyte and the labeling substance at a reaction portion containing a second binding substance that can bind to the analyte, and (b) a second device part holding a second insoluble carrier used for developing a liquid and a third insoluble carrier used for absorbing a liquid, in such a way that the first insoluble carrier does not come into contact with the second insoluble carrier and the third insoluble carrier.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: September 16, 2014
    Assignee: FUJIFILM Corporation
    Inventors: Junichi Katada, Hideyuki Karaki, Takayoshi Oyamada