With Reagent In Absorbent Or Bibulous Substrate Patents (Class 436/169)
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Patent number: 8101425Abstract: The invention provides devices, test kits and methods for removing target agents from a sample. The device contains one or more porous matrices having pore sizes larger than 10 ?m, and a plurality of particles impregnated therein. The target agents attach the device and are removed from the sample.Type: GrantFiled: June 9, 2005Date of Patent: January 24, 2012Assignee: Pathogen Removal and Diagnostic Technologies Inc.Inventor: Ruben G. Carbonell
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Publication number: 20120015444Abstract: A sensor comprises a sensor housing, having a channel; a porous substrate, in the channel; an analysis chemistry reagent, on the porous substrate; and a nozzle, in fluid connection with the channel. The porous substrate fills a cross section of the channel, and the cross-sectional area of the channel at the porous substrate is greater than the cross-sectional area at the nozzle.Type: ApplicationFiled: July 19, 2010Publication date: January 19, 2012Applicant: ANDALYZE, INC.Inventors: Debapriya Mazumdar, David G. Kellner
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Patent number: 8097467Abstract: A composition for use in the detection of an intoxicating drug comprising: (i) a first compound that absorbs UV radiation and generates emitted UV radiation at a wavelength absorbable by said intoxicating drug; and (ii) a second compound that absorbs UV radiation emitted by said intoxicating drug upon absorption by said intoxicating drug of said emitted UV radiation and that emits radiation in the visible spectrum is provided. In addition, methods for detecting an intoxicating drug in a sample comprising irradiating with UV radiation a sample contacted with one or two compounds that absorb UV radiation are provided.Type: GrantFiled: December 24, 2008Date of Patent: January 17, 2012Assignee: Heriot-Watt UniversityInventor: Jonathan Paul Henderson
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Patent number: 8093057Abstract: The present disclosure provides a device for simultaneously detecting hemoglobin and glycohemoglobin in blood. The device includes a lateral flow assay strip, a laser-induced epifluorescence detection device, and an LED detection device. The present disclosure further provides a method for simultaneously quantifying hemoglobin and glycohemoglobin in blood by an immunological method using the same.Type: GrantFiled: August 5, 2010Date of Patent: January 10, 2012Assignee: Boditechmed Inc.Inventors: Eui Yul Choi, Kie Bong Nahm, Jae Hoon Kim, Dong Seok Jeong, Sang Yeol Park, Joung Dae Moon, Jin Ha Jung, Young Min Kim, So Young Jung, Ae Kyung Park, Byeong Chul Kim, Sung Joong Kim
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Patent number: 8092758Abstract: A sample acquiring device for volumetric enumeration of white blood cells in a blood sample comprises a measurement cavity for receiving a blood sample. The measurement cavity has a predetermined fixed thickness. The sample acquiring device further comprises a reagent, which is arranged in a dried form on a surface defining the measurement cavity. The reagent comprises a hemolysing agent for lysing red blood cells in the blood sample, and a staining agent for selectively staining white blood cells in the blood sample. A system comprises the sample acquiring device and a measurement apparatus. The measurement apparatus comprises a sample acquiring device holder, a light source, and an imaging system for acquiring a digital image of a magnification of the sample. The measurement apparatus further comprises an image analyser arranged to analyse the acquired digital image for determining the number of white blood cells in the blood sample.Type: GrantFiled: March 10, 2006Date of Patent: January 10, 2012Assignee: Hemocue ABInventors: Stellan Lindberg, Johnny Svensson
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Patent number: 8093059Abstract: Provided is a method for simply quantitatively determining hexavalent chromium, including: separately bringing a plurality of test solutions into contact with a sample, the plurality of test solutions each containing a color change agent which changes in color upon reaction with hexavalent chromium, and an acid which dissolves the sample, the plurality of test solutions having different contents of the acid from each other; detecting color change in each of the test solutions; and when the color change is detected, specifying a range of content of hexavalent chromium in the sample on the basis of the content of the acid in a test solution with the color changed among the plurality of test solutions.Type: GrantFiled: February 16, 2009Date of Patent: January 10, 2012Assignee: Yazaki CorporationInventor: Yasuo Yamauchi
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Patent number: 8093055Abstract: A calibration tool for use in combination with a photoluminescent oxygen-sensitive working probe and an analytical instrument capable of reading the working probe. The calibration tool is effective for achieving two-point calibration of the analytical instrument, and includes at least first and second solid state compositions having different sensitivities to oxygen. The first composition is an oxygen-sensitive photoluminescent dye that is the same as that in the working probe, embedded within an oxygen-permeable carrier matrix that is the same as that in the working probe. The second composition is an oxygen-sensitive photoluminescent dye that is the same as that in the first composition, embedded within a carrier matrix that is different from that in the first composition. The oxygen sensitivity of the second composition is less than the oxygen sensitivity of the first composition.Type: GrantFiled: December 8, 2009Date of Patent: January 10, 2012Assignees: Mocon, Inc., Luxcel Biosciences, Ltd.Inventors: Daniel W. Mayer, Dmitri Boris Papkovsky
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Publication number: 20120003747Abstract: The present invention relates to a test strip for determining and/or quantifying a property of a sample, such as the concentration of an analyte, the pH, the viscosity, or the specific gravity of a fluid specimen. More particularly, the present invention relates to an improved test strip and scale for determining and/or quantifying a property of a sample, such as the concentration of an analyte, the pH, the viscosity, or the specific gravity of a fluid specimen.Type: ApplicationFiled: June 28, 2011Publication date: January 5, 2012Applicant: AKERS BIOSCIENCES, INC.Inventors: Susan Andrelczyk, Leonard L. Schluter
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Patent number: 8084268Abstract: A substrate is filled with a reagent that presents a stable free radical character, and that is capable of producing a visible reaction in the presence of at least one free radical scavenger analyte of the skin.Type: GrantFiled: February 27, 2006Date of Patent: December 27, 2011Assignee: L'OrealInventors: Francis Pruche, Quang Lan Nguyen, Jean-Pascal Hirt
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Patent number: 8080424Abstract: A method and a blood oxygen tester for determining whether a blood sample is arterial or venous blood are disclosed. A blood oxygen tester for determining whether a blood sample is arterial or venous blood includes a housing and a blood sample receptacle defined by the housing. A blood oxygen sensor is in communication with the blood sample receptacle and a test result indicator is in communication with the blood oxygen sensor. The indicator is responsive to the blood oxygen sensor for indicating whether a tested blood sample is arterial blood or venous blood.Type: GrantFiled: March 20, 2009Date of Patent: December 20, 2011Inventor: Ali Ghobadi
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Patent number: 8076150Abstract: Methods and apparatus for chemical warfare agent detection training are provided. More particularly, methods and apparatus are provided to simulate the detection of low volatility chemical warfare agents by simulating the use of currently fielded U.S. Army detection kits without exposure to hazardous agents. A simulant is disposed in a sample heating assembly. The sample heating assembly is placed over a detection window of a detector, and the simulant is heated in order to make a simulated detection.Type: GrantFiled: June 30, 2010Date of Patent: December 13, 2011Assignee: The United States of America as represented by the Secretary of the ArmyInventor: James A. Genovese
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Publication number: 20110300635Abstract: Articles and methods for the detection and/or quantification of organic analytes are described. The invention provides a chemical indicator test strip, comprising: a substrate; and a coating comprising a leuco dye complex on the substrate, the coating being insoluble in water and reactive with an organic analyte, the coating derived from a solution of leuco dye and developing agent. In another aspect, the coating further comprises adjuvant, in the form of a water-insoluble, polar, hydrophobic, aprotic material that extends the lower limit of detection for the analyte. In still another aspect, the present invention provides a method of using a chemical indicator test strip, comprising: (a) exposing the chemical indicator test strip to a sample comprising an organic analyte; (b) measuring a color change on the chemical indicator test strip following the exposing step; and (c) correlating the color change with the concentration of the analyte in the sample.Type: ApplicationFiled: August 16, 2011Publication date: December 8, 2011Inventor: Vinod P. Menon
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Patent number: 8071048Abstract: The invention concerns test elements, in particular diagnostic test elements, for determining the presence or concentration of biological, medical or biologically or medically effective substances including nucleic acids, proteins, viruses, microorganisms and cells, characterized in that these test elements contain nanofibers.Type: GrantFiled: June 10, 2011Date of Patent: December 6, 2011Assignee: Roche Diagnostics Operations, Inc.Inventor: Herbert Harttig
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Patent number: 8068666Abstract: There is provided a method for identifying the color intensities of red lines on a white test strip. The method comprises the following steps: (A) attaching the white test strip to a card that is larger and darker than the white test strip, (B) scanning the card with the attached white test strip, (C) creating a digital image of the card, in which each pixel in the digital image has a Red value, a Green value, and a Blue value, (D) using the digital image to calculate a color intensity for each red line on the white test strip.Type: GrantFiled: March 6, 2008Date of Patent: November 29, 2011Assignee: Rohm and Haas CompanyInventors: Walter Jay Gregory, William Harrison Stapelkamp
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Patent number: 8062902Abstract: A mammalian disease detecting system used to provide a visual indication of a possible disease state includes particles made of a material that is substantially clear or transparent to permit the easy visual detection of blood in urine of a mammal. The system also includes additives to permit visually detection of possible disease states or infections in mammals, such additives being of the type that are not reactive with the particular material.Type: GrantFiled: February 27, 2009Date of Patent: November 22, 2011Inventor: Francois Mestrallet
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Patent number: 8062901Abstract: The present invention provides devices, methods, and kits for the collection of a solid or semi-solid sample and analysis for the presence, absence, or quantity of an analyte. The invention provides a collection slide having a first card and a second card. The first card has a sample collection area. The first and second cards have orifices allowing the passage of fluid through the sample collection area, and the cards are hingeably connected to each other. The invention also provides an assay device having a housing with a test element, a results window, and a docking area for receiving and engaging the collection slide. In one embodiment the collection slide and device can be used to detect the presence of fecal occult blood (human hemoglobin) in a stool sample. Many other embodiments are described herein.Type: GrantFiled: April 30, 2005Date of Patent: November 22, 2011Assignee: Alere Switzerland GmbHInventors: Jielin Dai, Haipeng Hu, Feier Liao, Weidong Yu, Shaomin Sun
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Publication number: 20110281371Abstract: Systems and methods for detection of human fat metabolism byproducts and analysis of the detection for optimizing dietary results. The present invention includes a compact opto-electronic based sensor to significantly increase (factor of 20 or more) the accuracy and minimal detection limits for a standard ketone test strip.Type: ApplicationFiled: May 21, 2011Publication date: November 17, 2011Applicant: Emergent Detection, Inc.Inventors: R. Aaron Falk, Eric Fogel, Tram Pham
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Patent number: 8053625Abstract: Wetness indicators may include alarm devices that are designed to assist parents or attendants in identifying a wet diaper condition early on. These devices produce either a visual or an audible signal. Many of these devices rely on electronics, which may increase the expense of the absorbent article. Further, electronic devices rely on electrical sources and may be prone to failure if not utilized for an extended period of time.Type: GrantFiled: December 14, 2006Date of Patent: November 8, 2011Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Davis Dang H. Nhan, Andrew M. Long, Shirlee A. Weber, Darold D. Tippey, Meghan E. Collins
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Patent number: 8050745Abstract: The present invention employs image intensification for medical procedures within the human body. Methods and systems of the invention utilize infrared radiation (e.g. greater than about 750 nm) illumination and visualization of a surgical treatment area. Preferred methods and systems of the invention incorporate use of an infrared radiation visualization system which may be known as “night vision” systems.Type: GrantFiled: August 22, 2006Date of Patent: November 1, 2011Assignee: Doheny Eye InstituteInventors: Sean Caffey, Mark Humayun
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Patent number: 8038965Abstract: The present invention relates to a diagnostic kit and more specifically to a self contained diagnostic kit providing analysis of a sample by a sample collectin element and an immunochromatography test strip.Type: GrantFiled: May 30, 2007Date of Patent: October 18, 2011Assignee: Alere Switzerland GmbHInventor: Tomer Keren
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Patent number: 8030091Abstract: A test device and method for determining the presence or absence of one or more analytes in a fluid sample, the test device including a support or member bearing a mark thereon, and a matrix or member containing a capture zone. In operation, an observation area in the test device becomes transparent, thereby allowing the user to view a mark that is present on a support that is disposed beneath the observation area. Typically, the mark on the underlying support is configured as a minus (?) sign. In the absence of analyte in the sample, the test device presents a negative result as a minus (?) signal. In the presence of analyte in the sample, however, the mark operates in concert with a perpendicular test line on the observation area to present a positive result as a plus (+) signal that is visible to the user.Type: GrantFiled: April 14, 2009Date of Patent: October 4, 2011Assignee: Quidel CorporationInventors: Jeremy Jerome, Mark Daquipa, Bruce Jacono, Hans Boehringer, Paul Lambotte, Paul J. Lawrence
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Patent number: 8025850Abstract: An improved rapid diagnostic device, assay and multifunctional buffer reagent are provided for the detection of a target analyte in a fluid test sample. The 2-step assay utilizes a dual component flow-through device comprising a test unit and a dried indicator reagent delivery unit capable of receiving the fluid sample and multifunctional buffer, respectively. The test unit comprises a reaction zone containing immobilized capture reagent that can specifically bind to the target analyte, an absorbent zone supporting the reaction zone, and optionally, a blood separation zone in lateral fluid communication with the reaction zone. The dried indicator reagent delivery unit comprises a label zone permeated with a dried indicator reagent which is capable of being placed in transient fluid communication with the reaction zone of the test unit during the assay procedure.Type: GrantFiled: October 15, 2008Date of Patent: September 27, 2011Assignee: Medmira Inc.Inventor: Hermes K. W. Chan
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Patent number: 8025856Abstract: A tester for testing for explosives comprising a body, a lateral flow swab unit operably connected to the body, a explosives detecting reagent contained in the body, and a dispenser operatively connected to the body and the lateral flow swab unit. The dispenser selectively allows the explosives detecting reagent to be delivered to the lateral flow swab unit.Type: GrantFiled: August 18, 2005Date of Patent: September 27, 2011Assignee: Lawrence Livermore National Security, LLCInventors: Peter J. Nunes, Joel Del Eckels, John G. Reynolds, Philip F. Pagoria, Randall L. Simpson
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Patent number: 8021891Abstract: Compositions, methods and related apparatus, as can be used for selective protein detection and identification.Type: GrantFiled: November 17, 2008Date of Patent: September 20, 2011Assignee: University of MassachusettsInventors: Vincent Rotello, Uwe Bunz, Chang-Cheng You, Oscar Miranda, Ik-Bum Kim
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Patent number: 8021890Abstract: A method and kit for determining a concentration of iron in brake fluid when contacting a calorimetric reagent such that a color results. The level of iron can be used to determine the amount of active corrosion within a brake system and determine if special service procedures are required.Type: GrantFiled: November 3, 2008Date of Patent: September 20, 2011Inventor: Jon A. Petty
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Patent number: 8012763Abstract: A stationary medium is employed both to separate chemicals from a sample solution and also to generate surface-enhanced Raman scattering, so that spectral analysis of the separated analyte chemical can be performed. Applied driving force causes the sample to flow into the stationary medium and to distribute therethrough, thereby causing rapid separation of the analyte chemical, and surface-enhanced Raman scattered radiation is quickly detected, at a plurality of locations along a flow path defined by the stationary medium, for ultimate analysis.Type: GrantFiled: January 29, 2009Date of Patent: September 6, 2011Assignee: Real-Time Analyzers, Inc.Inventors: Chetan S. Shende, Stuart Farquharson, Paul Maksymiuk
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Patent number: 8012762Abstract: Test device for detection and visual indication of a specific analyte in a liquid sample such as a body fluid. The device includes a biodegradable housing, a test strip and a lid. The device is configured for placement in concentrate or dilute test liquid that is for example contained in a vessel. One end of the test strip wicks the liquid being tested into the housing and across a control site and test site which provide visual indication that the device is working correctly and whether the analyte being tested is present in the test liquid. An antibody specific to the antigen being tested may be provided on the test strip. The test device for example detects specific antigens in dilute urine, such that the device may be placed in a toilet bowl after urination.Type: GrantFiled: April 16, 2008Date of Patent: September 6, 2011Inventor: Steve Lee
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Patent number: 8012770Abstract: Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed.Type: GrantFiled: July 31, 2009Date of Patent: September 6, 2011Assignee: Invisible Sentinel, Inc.Inventors: Nicholas A. Siciliano, Martin Joseph Bouliane
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Patent number: 8012761Abstract: A method for rapidly detecting the presence of formaldehyde in a urine sample (e.g., urine or a urinary material associated therewith, such as headspace gas located associated with urine) is provided. The method includes contacting the urine sample with a substrate on which is disposed a colorant that is capable of undergoing a detectable color change in the presence of formaldehyde. Without intending to be limited by theory, it is believed that oxidation of the colorant by formaldehyde induces either a shift of the absorption maxima towards the red end of the spectrum (“bathochromic shift”) or towards the blue end of the spectrum (“hypsochromic shift”). The absorption shift provides a color difference that is detectable, either visually or through instrumentation, to indicate the presence of formaldehyde within the urine sample. For example, prior to contact with a urine sample, the colorant may be colorless or it may possess a certain color.Type: GrantFiled: December 14, 2006Date of Patent: September 6, 2011Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Rameshbabu Boga, Stephanie M. Martin, Molly K. Smith, Kevin Peter McGrath
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Patent number: 8003061Abstract: The present invention relates to a test strip for determining and/or quantifying a property of a sample, such as the concentration of an analyte, the pH, the viscosity, or the specific gravity of a fluid specimen. More particularly, the present invention relates to an improved test strip and scale for determining and/or quantifying a property of a sample, such as the concentration of an analyte, the pH, the viscosity, or the specific gravity of a fluid specimen.Type: GrantFiled: May 6, 2004Date of Patent: August 23, 2011Assignee: Akers Biosciences, Inc.Inventors: Susan Andrelczyk, Leonard L. Schluter
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Patent number: 8003407Abstract: The present invention relates to a lateral flow assay and system, including a test strip, for detection and quantification of analytes in samples, such as samples containing cells and fluid. In general, according to the present invention, a test strip for a lateral flow assay for detection of at least one analyte in a sample comprises: (1) a chromatographic strip, a sample filter, a fluid-impermeable barrier, and means for providing a mobilizable detectable agent that is capable of binding to the at least one analyte or to the capture agent after capturing the analyte to the chromatographic strip such that the mobilizable detectable agent migrates through the chromatographic strip and contacts sample that has passed through the sample filter and also has migrated through the chromatographic strip. The test strip allows detection with or without quantitation of an analyte in a sample containing whole cells.Type: GrantFiled: July 29, 2005Date of Patent: August 23, 2011Assignee: Relia Diagnostic Systems, LLCInventors: Siliang Zhou, William Rutter, Ning Liu
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Patent number: 8003404Abstract: Compositions, methods and related apparatus, as can be used for selective pathogen detection and identification.Type: GrantFiled: November 17, 2008Date of Patent: August 23, 2011Assignee: University of MassachusettsInventors: Vincent Rotello, Uwe Bunz, Ronnie Phillips, Oscar Miranda, Chang-Cheng You
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Patent number: 7998412Abstract: An ophthalmic device which comprises a holographic element comprising a medium comprising a phenylboronic acid group and, disposed therein, a hologram, wherein an optical characteristic of the element changes as a result of a variation of a physical property of the medium, and wherein the variation arises as a result of interaction between the medium and an analyte present in an ocular fluid.Type: GrantFiled: February 16, 2008Date of Patent: August 16, 2011Assignee: Smart Holograms LimitedInventors: Barry Burles, Roger Bradley Millington, Christopher Robin Lowe, Satyamoorthy Kabilan, Jeffrey Blyth
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Patent number: 7998748Abstract: The invention concerns test elements, in particular diagnostic test elements, for determining the presence or concentration of biological, medical or biologically or medically effective substances including nucleic acids, proteins, viruses, microorganisms and cells, characterized in that these test elements contain nanofibers.Type: GrantFiled: September 13, 2010Date of Patent: August 16, 2011Assignee: Roche Diagnostics Operations, Inc.Inventor: Herbert Harttig
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Patent number: 7993935Abstract: A test strip for immunochromatography comprising a sample receiving member, a label holding member, and a chromatography membrane is described. The chromatography membrane has a first detection zone and a second detection zone. The second detection zone is formed by utilizing a blocking material and the second substance. A method for producing above the test strip is also described.Type: GrantFiled: January 5, 2006Date of Patent: August 9, 2011Assignee: Sysmex CorporationInventors: Haruki Yamaguchi, Takehiro Hasegawa, Takeshi Imoarai
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Patent number: 7989213Abstract: Disclosed are Surface Enhanced Resonance Raman Spectroscopy (SERRS) probes and their use in detection methods for bioassays. Further disclosed is signal optimization of surface enhanced resonance Raman probes achieved by chemical modification of the probes. Also disclosed are methods for increasing the Raman cross-section by varying the chemical composition of a linker group linking a signal molecule to a nanoparticle surface. The signal molecules, such as dyes, may be modified with a linker group designed to both enhance the SERRS signal and to couple the signal molecule to the nanoparticle surface.Type: GrantFiled: June 16, 2009Date of Patent: August 2, 2011Assignee: Industrial Technology Research InstituteInventors: Philip Leslie Drake, Hsiang-Yuan Huang
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Patent number: 7985384Abstract: There is provided a simple, inexpensive reaction analysis kit and system capable of performing highly sensitive, quantitative measurement. A chemical luminescence reaction is employed and a sensor element is used to detect the reaction in a highly sensitive manner. That is, a reaction detection plate is used to transmit a signal detected in the sensor element via a reader coil and a reader and then analyze the reaction. The reaction detection plate has a) a membrane, b) a first antibody impregnated section that is disposed such that it faces the membrane and holds a first labeled antibody that specifically binds to a substance to be analyzed, c) a second antibody immobilized section that is provided in part of the membrane and has an immobilized second antibody, the second antibody specifically binding to the substance to be analyzed, and d) a sensor element that is disposed such that it faces the second antibody immobilized section and includes a light detector and a signal transceiver.Type: GrantFiled: June 15, 2007Date of Patent: July 26, 2011Assignee: Hitachi, Ltd.Inventors: Yoshiaki Yazawa, Takashi Anazawa, Kenko Uchida
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Patent number: 7976792Abstract: A biological specimen collection card comprises a specimen retaining panel, a rear panel, and a cover panel. There is an opening in the specimen retaining panel for retaining an absorbent insert which is to be impregnated with a biological specimen. The absorbent insert is exposed on both sides of the specimen retaining panel when the absorbent insert is retained in the opening. The rear panel is angularly spaced apart from the specimen retaining panel when the collection card is in an open configuration to facilitate drying of the biological specimen. The cover panel is movable between a first position and a second position. The collection card is in the open configuration when the cover panel is in the first position, and the collection card is in a closed configuration when the cover panel is in the second position. The cover panel covers the absorbent insert when the absorbent insert is retained in the opening and the collection card is in the closed position.Type: GrantFiled: May 30, 2007Date of Patent: July 12, 2011Inventor: Ally Shivji
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Patent number: 7977103Abstract: A method for detecting the onset of ovulation in a female mammal is provided. The method includes contacting mouth air of the female mammal with an arylmethane test chromogen in an amount effective to undergo a rapid and detectable color change in the presence of one or more volatile sulfur compounds. The color of the test chromogen is compared to a control color that corresponds to a pre-ovulatory sulfur content. The difference in color between the test chromogen and the control color is correlated to the onset of ovulation.Type: GrantFiled: April 20, 2006Date of Patent: July 12, 2011Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Stephanie Michelle Martin, RameshBabu Boga, John Gavin MacDonald
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Patent number: 7972872Abstract: This invention provides an immunochromatography detection apparatus exhibiting excellent convenience, sensitivity, and specificity, a detection method therefore, a kit using the same, and a method for producing such apparatus and kit, by constructing a solid-phase support, on which the conditions for the reaction wherein an analyte specifically binds to a labeled reagent containing a ligand that specifically binds to the analyte and those for the reaction wherein a capture reagent specifically binds to a complex of the analyte and the labeled reagent in the immunochromatography detection method are continuously optimized, and the pretreated specimens are optimized for such reactions.Type: GrantFiled: June 7, 2005Date of Patent: July 5, 2011Assignee: Denka Seiken Co., Ltd.Inventors: Ryo Shida, Hiromi Ito
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Publication number: 20110143450Abstract: The present invention provides devices, in particular lateral flow devices, for detecting a target analyte on a surface, in which the elements of collection and detection are integrated.Type: ApplicationFiled: June 18, 2009Publication date: June 16, 2011Inventor: Peter John White
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Patent number: 7955791Abstract: A test strip and method for detecting an analyte present in a sample.Type: GrantFiled: April 20, 2009Date of Patent: June 7, 2011Assignee: Relia Diagnostic SystemsInventors: Robert K. Dinello, Alan J. Polito, Stella Quan
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Patent number: 7951331Abstract: The invention relates to embodiments of an analysis system and to a method for analyzing a sample on an analytical test element, with the analysis system comprising a test element receptacle for receiving and positioning a test element in an analysis position. In an exemplary embodiment, the test element receptacle contains a guide part and a lock part, the guide part having means for guiding a test element into and out of the analysis position, the lock part comprising a frame and a bolt element, which frame and bolt element are connected to one another by a hinge. The bolt element can be pivoted about the hinge between a first position and a second position with respect to the frame. The bolt element comprises a latching lug for engaging in a recess in test element when the bolt element is in the first position and when the test element is positioned in the analysis position.Type: GrantFiled: July 11, 2007Date of Patent: May 31, 2011Assignee: Roche Diagnostics Operations, Inc.Inventors: Bernd Roesicke, Stefan Kalveram, Frederic Wehowski, Michael Goetz
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Patent number: 7943395Abstract: A flow-through assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes multiple detection zones, one of which is premised on “competitive” binding of the analyte and the other is premised on “sandwich” binding of the analyte. The present inventors believe that the combination of these zones may enable the detection of an analyte over extended concentration ranges.Type: GrantFiled: November 21, 2003Date of Patent: May 17, 2011Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Ning Wei, Rameshbabu Boga
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Patent number: 7939340Abstract: The invention relates to compositions, kits and methods used in hydroxyl radical detection. In some embodiments, the invention relates to compositions comprising a dye preferably methylene blue immobilized on a substrate. In additional embodiments, the invention relates methods of correlating color changes of a dye to the presence or absence of hydroxyl radicals. In some embodiments, the invention relates to a methylene blue dye containing test strip and its use in a method for detecting the presence of hydroxyl radicals.Type: GrantFiled: June 28, 2006Date of Patent: May 10, 2011Assignee: Board Of Trustees Of Michigan State UniversityInventors: Andrea Yuki Satoh, Susan J. Masten, James Trosko
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Patent number: 7939344Abstract: New applications for the use of distinguishable particulate labels available in a variety of hues and sized in the submicron range are described. These applications include profiling of cellular components, obtaining secretion patterns, identifying a multiplicity of components in chromatographic or electrophoretic techniques and identification of desired immunoglobulin secreting cells.Type: GrantFiled: August 8, 2008Date of Patent: May 10, 2011Assignee: Trellis Bioscience, Inc.Inventors: Lawrence M. Kauvar, Remy Cromer, William D. Harriman, Ellen J. Collarini
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Patent number: 7927865Abstract: Diagnostic in-vitro devices for use in the assaying of biological fluids are provided which include cover plates or backing strips which exhibit hydrophilic properties to assist in transport of the biological fluid or retention of same within the device. Exemplary diagnostic devices include lateral flow devices, microfluidic devices and microtiter plates. The devices may also be comprised of low fluorescent material in order to facilitate any diagnostic determination by use of fluorescent emissions. Hydrophilic properties may be imparted to the cover plates or backing strips by physical or chemical treatment thereof. The cover plates or backing strips may exhibit heat sealable or pressure sensitive properties.Type: GrantFiled: December 5, 2008Date of Patent: April 19, 2011Assignee: Adhesives Research, Inc.Inventors: William Meathrel, Herbert M. Hand, Sr., Li-Hung Su
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Patent number: 7927828Abstract: Methods and immunoassays for diagnosing a bite or sting of a venomous organism in a patient having symptoms consistent with such a bite or sting are provided. A sample of venom is collected from the area of the suspected bite or sting using a swab and then contacted with an antibody that specifically binds to an antigenic site on venom present in the sample. Binding is then detected. The invention is illustrated by examples showing diagnosis of brown recluse spider bite, distinguishing it from other diagnoses with which it is often confused. This extremely sensitive test can detect venom antigens down to about 20 picograms even after the sample has been shipped and stored for periods of up to three weeks during the summer.Type: GrantFiled: October 17, 2006Date of Patent: April 19, 2011Assignee: Spidertech, a division of Stoecker & associates, LLCInventors: William V. Stoecker, Hernan F. Gomez, Jonathan A. Green, David L. McGlasson
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Publication number: 20110065194Abstract: A microfluidic detection device is disclosed, which includes a porous membrane, a wicking pad, and an optical sensor. The porous membrane has a first end and an opposite second end, and the first end has a sample-loading area for receiving sample molecules. The wicking pad is connected with the second end of the porous membrane to move the sample molecules from the sample-loading area of the porous membrane to the second end thereof. The optical sensor has a detection zone which faces the porous membrane for sensing the sample molecules. Also, a method for detecting molecules is disclosed, which uses the aforesaid device. The method and the device can achieve the purpose of real-time detection and fast-screening for molecules.Type: ApplicationFiled: April 23, 2010Publication date: March 17, 2011Applicant: Forward Electronics Co., Ltd.Inventors: Ren-Kun Liang, Yu-Chia Tsao, Woo-Hu Tsai
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Patent number: 7901623Abstract: A lateral flow strip assay apparatus comprising a housing; a lateral flow strip in the housing, the lateral flow strip having a receiving portion; a sample collection unit; and a reagent reservoir. Saliva and/or buccal cells are collected from an individual using the sample collection unit. The sample collection unit is immersed in the reagent reservoir. The tip of the lateral flow strip is immersed in the reservoir and the reagent/sample mixture wicks up into the lateral flow strip to perform the assay.Type: GrantFiled: September 26, 2006Date of Patent: March 8, 2011Assignee: Lawrence Livermore National Security, LLCInventors: Robin R. Miles, William J. Benett, Matthew A. Coleman, Francesca S. Pearson, Shanavaz L. Nasarabadi