Utilizing A Centrifuge Or Compartmented Rotor Patents (Class 436/45)
  • Patent number: 10427158
    Abstract: A fluidic centripetal apparatus for testing components of a biological material in a fluid is presented. The fluidic centripetal device is adapted to be received within a rotatable holder. The apparatus comprises a fluidic component layer having fluidic features on at least a front face and a bottom component layer bonded to a rear of the fluidic component layer thereby creating a fluidic network through which the fluid flows under centripetal force. In one embodiment, the fluidic feature may be a bottom-fillable chamber coupled to an entry channel for receiving the fluid, the chamber inlet being provided at an outer side of the bottom-fillable chamber.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: October 1, 2019
    Assignees: UNIVERSITÉ LAVAL, Meridian Bioscience Canada Inc.
    Inventors: Régis Peytavi, Sébastien Chapdelaine
  • Patent number: 10005271
    Abstract: Embodiments generally relate to chips containing one or more hermetically sealed chambers that may be dismantled under controlled conditions using a release technique. In one embodiment a chip comprises a first hermetic seal bonding first and second elements to create a first chamber and a second hermetic seal bonding third and fourth elements to create a second chamber encompassing the first chamber. The first hermetic seal may be broken open independently of the second hermetic seal by the application of a mechanical or thermal technique.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: June 26, 2018
    Inventors: Raymond Miller Karam, Thomas Wynne, Anthony Thomas Chobot
  • Patent number: 9726685
    Abstract: Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: August 8, 2017
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Beom-seok Lee, Yoon-kyoung Cho, Jong-myeon Park, Jeong-gun Lee
  • Patent number: 9562860
    Abstract: Methods and devices for cytometric analysis are provided. A cytometry apparatus is provided which may be used with a stationary sample cuvette for analysis of a stationary sample or with a flow sample cuvette for analysis of a flowing sample. The methods and devices provided herein may be used to perform cytometric analysis of samples under a wide range of experimental and environmental conditions.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: February 7, 2017
    Assignee: Theranos, Inc.
    Inventors: Chinmay Pangarkar, Karan Mohan
  • Patent number: 9557249
    Abstract: A system and apparatuses or devices capable of automatically performing processes of cell treatment preparatory to flow cytometry and similar cytological studies in a fully automated and streamlined manner are provided. The system and apparatuses or devices are adapted for preparation and (pre)processing of cell samples, e.g., blood and/or bone marrow samples.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: January 31, 2017
    Assignee: INSTRUNOR AS
    Inventors: Oystein Helge Ljungmann, Torstein Ljungmann
  • Patent number: 9505012
    Abstract: Illustrative embodiments of automated sample workcells and methods of operation are disclosed.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: November 29, 2016
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Joerg Haechler
  • Patent number: 9475048
    Abstract: A centrifugal force-based microfluidic device for a multiplexed analysis and an analyzing method using the same are provided. The microfluidic device includes a platform and a microfluidic structure including a plurality of chambers formed within the platform and valves positioned between the chambers. The microfluidic structure includes a sample separation chamber connected to a sample injection hole and a plurality of reaction chambers accommodating two or more types of markers specifically reacting to different types of target materials, separately by type.
    Type: Grant
    Filed: January 25, 2012
    Date of Patent: October 25, 2016
    Assignee: UNIST (ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)
    Inventors: Yoon-Kyoung Cho, Ji-Woon Park
  • Patent number: 9417178
    Abstract: A microchip including a fluid circuit therein and a specimen inlet for introducing a specimen containing a first component and a second component different in specific gravity from each other into the fluid circuit is provided, in which the fluid circuit includes a specimen measurement unit connected to the specimen inlet and having a prescribed volume for measuring the specimen introduced through the specimen inlet and a separation unit which is a site connected to the specimen measurement unit and having a capacity capable of storing the total amount of the measured specimen, for storing the total amount of the measured specimen and separating the first component and the second component in the stored specimen from each other.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: August 16, 2016
    Assignee: Rohm Co., Ltd.
    Inventors: Shun Momose, Hiroki Takeuchi
  • Patent number: 9289765
    Abstract: A microfluidic device having a delay structure and a sample testing apparatus including the microfluidic device are provided. The microfluidic device includes: a reaction chamber which contains a reagent capable of reacting with a sample; a distribution channel through which the sample is provided to the reaction chamber; an inlet channel through which the at least one reaction chamber is connected with the distribution channel; and a delay structure which is located between the at least one reaction chamber and the distribution channel, and delays movement of contents of the reaction chamber to the distribution channel.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: March 22, 2016
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Do Gyoon Kim, Han Sang Kim, Yang Ui Lee, Yoon Kyoung Cho, Na Hui Kim, Sang Bum Park
  • Patent number: 9162227
    Abstract: A sample processing cartridge for carrying out processing under centrifugal force acting in at least two directions as the orientation of cartridge relative to centrifugal force is changed, the cartridge comprising: a first cavity adapted to contain a sample; and a second cavity in fluid communication with the first cavity, wherein the first and second cavities are arranged such that the sample in the first cavity is moved therefrom to the second cavity as a centrifugal force acting on the cartridge is changed from a first direction to a second direction, the first cavity is elongated perpendicular to the centrifugal force acting in the first direction, and the second cavity is more shallow than the first cavity and more extended in the direction of the centrifugal force acting in the second direction than the first cavity is extended in the direction of the centrifugal force acting in the first direction.
    Type: Grant
    Filed: December 28, 2010
    Date of Patent: October 20, 2015
    Assignee: Stiftelsen Sintef
    Inventor: Stig Morten Borch
  • Patent number: 9101935
    Abstract: A microfluidic apparatus having an additional chamber containing material configured to prevent cross contamination between reaction chambers contained therein, and a control method thereof are provided. The microfluidic apparatus includes a sample chamber configured to accommodate a sample, a plurality of reaction chambers each configured to accommodate a reagent, a distribution channel configured to distribute the sample into the plurality of reaction chambers, a mixture prevention chamber connected to the distribution channel and containing a mixture prevention material configured to prevent the reagents accommodated in the plurality of reaction chambers from being mixed with each other, and a valve disposed within the distribution channel and configured to open and close the distribution channel.
    Type: Grant
    Filed: September 5, 2012
    Date of Patent: August 11, 2015
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Sang Bum Park, Na Hui Kim, Sang Hyun Lee
  • Patent number: 9052275
    Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: June 9, 2015
    Assignee: Cue Inc.
    Inventors: Ayub Khattak, Clinton Sever
  • Patent number: 9046503
    Abstract: An analyzing device includes: an operation cavity that is adjacent to a first reserving cavity retaining a sample liquid; a connecting section provided on a side wall of the first reserving cavity to suck the sample liquid by a capillary force and transfer the sample liquid to the operation cavity; and second reserving cavities that are disposed outside the operation cavity in the circumferential direction of the rotational driving and communicate with the outermost position of the operation cavity through a connecting passage. The connecting section is circumferentially extended farther than the liquid level of the sample liquid retained in the first reserving cavity.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: June 2, 2015
    Assignee: Panasonic Healthcare Co., Ltd.
    Inventors: Hiroshi Saiki, Hirofumi Sugimoto, Seiji Sogabe
  • Publication number: 20150132798
    Abstract: The invention provides an integrated sequential sample preparation system using a sequential centrifuge for preparing samples for analysis. Methods of more efficiently preparing discrete samples sequentially for subsequent analysis are also provided. The apparatus and methods for sequentially preparing discrete samples provide improved operating efficiencies over conventional preparation processes that use batch centrifugation systems. Such advantages include reducing dwell time, increasing system throughput, reducing sample preparation system footprint, and improving precision of the analytical process. The integrated sequential preparation system with the integrated sequential centrifuge further provides the capability of handling critical or STAT samples without compromising the operating efficiencies achieved by preparing discrete samples in a sequential manner.
    Type: Application
    Filed: January 9, 2015
    Publication date: May 14, 2015
    Inventors: William Alan Fox, Charles L. Carrico, JR.
  • Publication number: 20150111299
    Abstract: When a STAT sample which needs to be centrifuged is inputted in the system, a measure to quickly realize centrifugation of the STAT sample is necessary. In view of the foregoing problem, the invention provides a specimen processing and conveying system in which a centrifuge module incorporated, the centrifuge module being capable of discriminating the operation status of the system at the time point when a STAT sample is inputted and the attribute of the inputted sample and starting centrifugation operation on the basis of the input interval of samples or the arrival interval at the device carrying out centrifugation, and thus capable of starting centrifugation operation quickly when a single or a group of plural samples of urgency is inputted.
    Type: Application
    Filed: May 24, 2013
    Publication date: April 23, 2015
    Applicant: Hitachi High-echnologies Corporation
    Inventors: Osamu Watabe, Shigeru Yano
  • Patent number: 9012228
    Abstract: Provided is a method for checking a blood status including: a step of supplying blood to the centrifugal container of a disk; a step of rotating the disk to centrifuge the blood cells and blood plasma in the centrifuge container, and detecting the actual moving distance per hour of the blood cells in the centrifugal container; and a step of establishing a first graph which represents the actual moving distance of the blood cells per hour, and a second graph which represents the theoretical moving distance of the blood cells per hour, and thereafter calculating the hematocrit of the blood cells and the viscosity of the blood plasma by comparing the first graph with the second graph.
    Type: Grant
    Filed: December 12, 2012
    Date of Patent: April 21, 2015
    Assignee: Postech Academy-Industry Foundation
    Inventors: Dong Sung Kim, Moonwoo La, Sangmin Park
  • Patent number: 8956578
    Abstract: The invention provides an integrated sequential sample preparation system using a sequential centrifuge for preparing samples for analysis. Methods of more efficiently preparing discrete samples sequentially for subsequent analysis are also provided. The apparatus and methods for sequentially preparing discrete samples provide improved operating efficiencies over conventional preparation processes that use batch centrifugation systems. Such advantages include reducing dwell time, increasing system throughput, reducing sample preparation system footprint, and improving precision of the analytical process. The integrated sequential preparation system with the integrated sequential centrifuge further provides the capability of handling critical or STAT samples without compromising the operating efficiencies achieved by preparing discrete samples in a sequential manner.
    Type: Grant
    Filed: March 10, 2009
    Date of Patent: February 17, 2015
    Assignee: TriPath Imaging, Inc.
    Inventors: William Alan Fox, Charles L. Carrico, Jr.
  • Patent number: 8951417
    Abstract: A method of transporting magnetic particles enables magnetic particles to be transported between a plurality of microfluidic chambers which are connected to one another via a fluidic connection on a radially inner side, and are fluidically separated from one another on a radially outer side. Magnetic forces and centrifugal forces are exploited to transport magnetic particles from one chamber to another across phase boundaries.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: February 10, 2015
    Assignee: Hahn-Schickard-Gesellschaft fuer angewandte Forschung e.V
    Inventors: Oliver Strohmeier, Felix Von Stetten, Daniel Mark
  • Patent number: 8951803
    Abstract: A sample analyzer comprising: a reagent container holder, configured to rotate around a rotational axis and to hold a reagent container containing a reagent; a reagent aspirator for aspirating, at a reagent aspirating position, the reagent from the reagent container held by the reagent container holder; an analysis section for analyzing a measurement sample prepared from the reagent aspirated by the reagent aspirator and a sample; and a controller for controlling: the reagent container holder to rotate and thereby transport the reagent container to the reagent aspirating position, the reagent aspirator to aspirate the reagent from the reagent container, and the reagent container holder to accelerate and decelerate alternately while being rotated is disclosed. A sample analyzing method is also disclosed.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: February 10, 2015
    Assignee: Sysmex Corporation
    Inventors: Kazunori Mototsu, Teruyuki Uekawa
  • Patent number: 8945480
    Abstract: The invention provides an apparatus and methodology to carry out biochemical testing on a centrifugal platform using flow splitting technique. In conventional biochemical testing, reagents need to be loaded individually into each reservoir. By using the flow splitting technique in this invention, one reagent only need to be loaded once, then, it can be evenly distributed into each reaction chambers in single or multiple layers format. The invention greatly reduces the required manpower when large numbers of assays are integrated on one platform. Because of the invention, many medical examinations can be performed efficiently, thus reduce the waste of manpower, time and cost.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: February 3, 2015
    Assignee: Feng Chia University
    Inventors: Chih-Hsin Shih, Ho-Chin Wu, Yu-Ping Yang
  • Patent number: 8936754
    Abstract: There is provided a high-accuracy automatic analysis device achieving both of measurement in a wide concentration range and high sensitivity at a low concentration. The signals of a plurality of wavelengths ?1 to ?12 where the sensitivity of light absorption caused by fine particles is high from a light source 40 are converted to absorbances by a spectroscopic optical system (detector) 41. The absorbances are converted to a secondary parameter from in which a noise component is cancelled by using a previously-defined conversion table 54, so that a concentration of a measured material (predetermined component) is calculated by an operation unit (calculating means) 53 based on the secondary parameter. Thus, analysis being resistant to the noise even at the low concentration can be achieved in a range up to a high concentration.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: January 20, 2015
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Isao Yamazaki, Hiroaki Ishizawa, Sakuichiro Adachi
  • Patent number: 8926901
    Abstract: A sample analyzer that analyzes a sample by using a reagent contained in a reagent container is disclosed. The sample analyzer includes a container holding unit which is configured to hold a plurality of reagent containers, and a plurality of electronic tags is attached to the plurality of reagent containers, on which a reagent information regarding reagents is recorded. The sample analyzer further includes an antenna section which emits a radio wave to an electronic tag of a reagent container. A range of the radio wave emitted from the antenna section to the electronic tag is limited to a predetermined range or by a limiting member which is arranged between the antenna section and the electronic tag of the reagent container, and which is configured to limit a range of the radio wave emitted from the antenna section to the electronic tag.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: January 6, 2015
    Assignee: Sysmex Corporation
    Inventor: Kazunori Mototsu
  • Patent number: 8920658
    Abstract: Methods and apparatus for desolvating flowing liquid streams while retaining temporal resolution of dissolved substrates are disclosed. A novel small-scale self-regulating spray dryer preserves temporal resolution while desolvating a liquid chromatography eluent stream and depositing the solute onto an optical surface for infrared spectrographic analysis. The liquid eluent is pumped through a heated nebulizer to create a high-speed jet of solute containing liquid and solvent vapor. This jet is directed circumferentially inside a hot cylindrical cavity. Centrifugal force causes the larger liquid droplets to travel along the outer diameter of the cavity. The cavity surface is heated to cause the droplets to film boil. Film boiling reduces droplet contact with the cavity surface thereby retaining the solute in the droplets. The solute temperature is limited by controlling the pressure into which the solvent evaporates from the droplets.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: December 30, 2014
    Assignee: Spectra Analysis Instruments, Inc.
    Inventors: William W. Carson, Sidney Bourne
  • Patent number: 8920722
    Abstract: A sample analyzer for analyzing a measurement sample prepared by a sample and a reagent is disclosed. The sample analyzer includes a rotatable first holding section for holding a first reagent container containing a first reagent and a second reagent container containing a second reagent circularly, a rotatable second holding section for holding a third reagent container containing a third reagent and a fourth reagent container containing a fourth reagent circularly, the second holding section being arranged concentrically relative to the first holding section, a dispenser for dispensing a reagent selected from the first to fourth reagents into a measurement sample container for preparing a measurement sample, and a controller.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: December 30, 2014
    Assignee: Sysmex Corporation
    Inventors: Nobuhiro Kitagawa, Shuhei Kaneko, Kyozo Fujita
  • Patent number: 8865005
    Abstract: Devices for controlling fluid flow, in particular microfluidic devices, are described, which exploit gas/liquid interfaces to control liquid flow in accordance with application requirements. Devices for on/off flow switching, centrifugal separation, mixing, metering and aliquoting are described.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: October 21, 2014
    Assignee: Biosurfit, S.A.
    Inventors: Joäo Garcia Da Fonseca, Nuno Alexandre Reis Esteves, Robert Burger
  • Publication number: 20140273241
    Abstract: Diagnostic analyzers with pretreatment carousels and related methods are disclosed. An example apparatus includes a first carousel that includes a first annular array of slots to receive a first vessel. The example first carousel also includes a first track of rotation about the first carousel having a first diameter and a second track of rotation about the first carousel having a second diameter smaller than the first diameter. The example apparatus includes a first diverter to move the first vessel from the first track to the second track. In addition, the example apparatus includes a second carousel coaxial with the first carousel. The example second carousel includes a second annular array of slots to receive a second vessel.
    Type: Application
    Filed: December 27, 2013
    Publication date: September 18, 2014
    Inventors: Brian L. Ochranek, David C. Arnquist
  • Patent number: 8834791
    Abstract: The present invention is a sample analyzer comprising: a reagent storage configured to store a reagent container containing a reagent used for analyzing a sample, wherein the reagent storage comprises a liquid storing section which stores a liquid such that a surface of the liquid contacts an air within the reagent storage; and a liquid supply unit configured to supply the liquid into the liquid storing section.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: September 16, 2014
    Assignee: Sysmex Corporation
    Inventors: Hironori Katsumi, Kazuya Fukuda
  • Patent number: 8808623
    Abstract: A diagnosis assisting system comprising: an analyzing section for analyzing a sample collected from a subject; a determining section for determining whether there is a possibility that a subject has a predetermined disease based on an analysis result obtained by the analyzing section; a notification section for notifying the possibility when the determining section has determined that there is the possibility; and a diagnosis assisting information display section for displaying a diagnosis assisting information screen which displays diagnosis assisting information related to the predetermined disease, is disclosed. A diagnosis assisting information providing device and a computer program product are also disclosed.
    Type: Grant
    Filed: July 28, 2008
    Date of Patent: August 19, 2014
    Assignee: Sysmex Corporation
    Inventors: Jo Linssen, Matthias Guhl
  • Patent number: 8796029
    Abstract: A system for processing a target material includes; a cartridge which stores a material which reacts with the target material, and may include at least one chamber and at least one valve connected to the at least one chamber, a first module which may be loaded with the at least one cartridge and may rotate, a second module which may selectively open or close the at least one valve, a third module which may selectively control the temperature of the at least one chamber, and a control module which may control the first module, the second module and the third module.
    Type: Grant
    Filed: March 31, 2009
    Date of Patent: August 5, 2014
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Won Seok Chung, Kak Namkoong, Joonho Kim, Kyuyoun Hwang, Heekyun Lim
  • Patent number: 8795593
    Abstract: An automated testing system includes one or more laboratory devices that operate together to perform an assay. The testing system is designed such that a laboratory device may be seamlessly integrated with the remaining devices in a quick and effortless manner. Specifically, the laboratory device is securely mounted on a slidable cart with fluid and electrical connections established therebetween. The slidable cart is in turn adapted to releasably engage with a docking station that is fixedly mounted on the workspace floor, the docking station being provided with at least one fluid input connection, an input power connection and at least one communication signal connection that are relatively permanent in nature. In order to couple the cart to the docking station, the cart is rolled generally into position above the docking station using complementary alignment posts and tracks.
    Type: Grant
    Filed: June 9, 2009
    Date of Patent: August 5, 2014
    Inventors: Michael J. Nichols, Louis J. Guarracina
  • Publication number: 20140170756
    Abstract: Apparatus and processes for placing sample cuvettes at measuring points, dispensing a reagent into the cuvettes, and forwarding used cuvettes to a receptacle after finishing the measurements. The apparatus has an incubation module (1) for incubating sample cuvettes (7), a reagent module (3) containing a reagent of an amount needed for the assay, and a measuring module (2) favorably accommodating optical measuring points. Arms (K1 . . . KN) can move the sample cuvettes (7).
    Type: Application
    Filed: February 21, 2014
    Publication date: June 19, 2014
    Applicant: DIAGON Kft.
    Inventors: Matyas Petoe, Laszlo Izsak, Jozsef Antal
  • Patent number: 8734720
    Abstract: Automated testing system arrangements using a docking station. One system includes a unit including: a) a polygonal base having a plurality of sides, a number of the plurality of sides including a docking station for mating with a mobile equipment carrying cart; and b) a robotic arm having a stationary base positioned on or in the polygonal base and configured to interact with the equipment on each mobile equipment carrying cart.
    Type: Grant
    Filed: March 27, 2009
    Date of Patent: May 27, 2014
    Inventors: Michael J. Nichols, Louis J. Guarracina
  • Patent number: 8695813
    Abstract: Methods and apparatus for desolvating flowing liquid streams while retaining temporal resolution of dissolved substrates are disclosed. A novel small-scale self-regulating spray dryer preserves temporal resolution while desolvating a liquid chromatography eluent stream and depositing the solute onto an optical surface for infrared spectrographic analysis. The liquid eluent is pumped through a heated nebulizer to create a high-speed jet of solute containing liquid and solvent vapor. This jet is directed circumferentially inside a hot cylindrical cavity. Centrifugal force causes the larger liquid droplets to travel along the outer diameter of the cavity. The cavity surface is heated to cause the droplets to film boil. Film boiling reduces droplet contact with the cavity surface thereby retaining the solute in the droplets. The solute temperature is limited by controlling the pressure into which the solvent evaporates from the droplets.
    Type: Grant
    Filed: December 8, 2007
    Date of Patent: April 15, 2014
    Assignee: Spectra Analysis Instruments, Incorporated
    Inventors: William W. Carson, Sidney Bourne
  • Patent number: 8691148
    Abstract: The invention provides a small-sized automatic analyzer being compact, enabling a large number of analysis items to be carried out, and having a high processing speed. The automatic analyzer is particularly suitably applied to a medical analyzer used for qualitative/quantitative analysis of living body samples, such as urine and blood. A plurality of sample dispensing mechanism s capable of being operated independently of each other are provided to suck a sample from any one of a plurality of sample suction positions and to discharge the sucked sample to any one of a plurality of positions on a reaction disk. The automatic analyzer having a high processing capability can be thus realized without increasing the system size.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: April 8, 2014
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Hideyuki Yanami, Isao Yamazaki, Masaaki Hanawa, Hitoshi Otake
  • Patent number: 8679424
    Abstract: A biotip according to an embodiment of the invention moves a reaction mixture along a longitudinal direction under the force of gravity. The biotip includes a chamber formed of a transparent material and filled with a liquid having a smaller specific gravity than the reaction mixture and immiscible with the reaction mixture, and a seal that seals the chamber. The liquid has a volume resistivity of greater than 0 ?·cm and 5×1013 ?·cm or less.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: March 25, 2014
    Assignee: Seiko Epson Corporation
    Inventor: Hiroshi Koeda
  • Patent number: 8667833
    Abstract: A protective cap 2 is engaged with a latch 10 of a diluent container 5 so as to fix the diluent container 5 at a liquid holding position of a diluent container containing section 11. The engagement is released when the protective cap 2 is set to an open position against the engagement so as to expose an inlet 13. When the protective cap 2 is shifted from the open position to a closed position, the protective cap 2 pushes the diluent container 5 into a liquid discharge position. Thus, it is possible to preserve a diluent for a long period of time and to easily open the diluent container 5 without having to complicate the structure of an analysis apparatus.
    Type: Grant
    Filed: October 27, 2008
    Date of Patent: March 11, 2014
    Assignee: Panasonic Corporation
    Inventors: Hiroshi Saiki, Yoshiyuki Fujii, Nobuyasu Higashi, Masaaki Kitoh, Kenji Okada, Hirofumi Sugimoto
  • Patent number: 8652407
    Abstract: A self-contained assay device that is capable of detecting various analyte(s), including bioanalytes, in specimens for example, from biological sources.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: February 18, 2014
    Assignee: PalmStat Diagnostics, LLC
    Inventors: Pete Wilson, Eric Butt, Vincent Mata
  • Patent number: 8617041
    Abstract: Illustrative embodiments of automated sample workcells and methods of operation are disclosed.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: December 31, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Joerg Haechler
  • Patent number: 8596150
    Abstract: An inlet (37a) of a capillary tube channel that feeds a liquid from a mixing cavity (39) to measurement spots is formed near one (4) of the wall surfaces of the upper and lower surfaces of the mixing cavity (39) situated in a direction of oscillation for mixing. On the other wall surface (3), a level difference (39a) is formed such that an inner gap is larger than an outer gap in the mixing cavity (39), so that a solution is reliably fed from the mixing cavity to the measurement cells.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: December 3, 2013
    Assignee: Panasonic Corporation
    Inventors: Hiroshi Saiki, Tomohiro Kijima, Kenji Ishibashi, Kouzou Tagashira
  • Publication number: 20130316388
    Abstract: This invention relates to an apparatus and a process for rapid, high-throughput analysis of fatty acids in a plurality of samples. The apparatus comprises at least one multi-vessel plate, wherein each vessel is a unit for holding a sample, or mixing and/or reacting a sample with one or more solvents or reagents; at least one matching multi-cap mat capable of sealing the vessels of the multi-vessel plate during the holding, mixing and/or reacting the sample; at least one multi-vessel plate holder having sealing units, whereby the multi-vessel plate holder, when the sealing units are engaged, presses the matching multi-cap mat onto the tops of the vessels in the multi-vessel plate sealing the vessels, so as to withstand high pressure and high temperature conditions. The process employs the apparatus that enables automated, high-throughput analysis of twenty-four fatty acid from a plurality of samples by gas chromatography flame ionization detection.
    Type: Application
    Filed: March 14, 2013
    Publication date: November 28, 2013
    Applicant: HEALTH DIAGNOSTIC LABORATORY, INC.
    Inventors: James BOROWSKI, Alexandra SHERMAN, Jennifer WARD, Joseph P. McCONNELL
  • Patent number: 8580567
    Abstract: A method for the automated analysis of liquid samples using at least one microfluidic structure is disclosed as well as microfluidic structures, a device having at least one of the microfluidic structures, a kit and a system including such microfluidic device. In one embodiment, the method may comprise: transferring a sample into a first fluid reservoir which is in fluid communication with a second fluid reservoir by a flow channel; spinning the microfluidic structure so as to transport the sample into one or more dead-end recesses or chambers; transferring a control fluid into the structure which generates a barrier to flow and diffusion of the sample contained in the one or more dead-end recesses or chambers; and analyzing the sample contained in the one or more dead-end recesses or chambers.
    Type: Grant
    Filed: October 13, 2010
    Date of Patent: November 12, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Emad Sarofim, Edwin Oosterbroek, Claudio Cherubini, Nenad Milicevic
  • Patent number: 8535541
    Abstract: Disclosed is a method for separating immunomagnetic bead labeled particulates. A carrier board is formed with at least one flow channel structure, which includes an inner reservoir, an outer reservoir, and at least one micro flow channel in communication with the inner reservoir and the outer reservoir. The method includes labeling target particulates with immunomagnetic bead, introducing a sample fluid into the inner reservoir, and applying a magnetic force and a driving force, wherein the driving force drives the particulates not labeled with immunomagnetic bead to flow through the micro flow channel to the outer reservoir, while the magnetic force attracts the particulates labeled with the immunomagnetic bead to retain in the inner reservoir. The driving force may be centrifugal force, pressure, or surface tension.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: September 17, 2013
    Assignee: National Taiwan University
    Inventors: Andrew Man Chung Wo, Yu-Cheng Pan, Ken-Chao Chen, Chen-Lin Chen
  • Patent number: 8535945
    Abstract: A system and method for concentrating samples. The system can include a first container adapted to contain a sample. The first container can include a first portion and a second portion adapted to be removably coupled to the first portion. The system can further include a second container comprising the second portion and a third portion adapted to be removably coupled to the second portion. The method can include centrifuging the first container in a first orientation toward the second portion of the first container; retaining a concentrate of the sample in the second portion of the first container; and centrifuging the second container in a second orientation toward the third portion of the second container, such that the concentrate retained in the second portion is moved into the third portion of the second container, the second orientation being different from the first orientation.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: September 17, 2013
    Assignee: 3M Innovative Properties Company
    Inventor: Kurt J. Halverson
  • Patent number: 8501000
    Abstract: The present invention includes a container and a method of separating one or more components of interest bound to magnetic particles using centrifugal forces.
    Type: Grant
    Filed: October 10, 2012
    Date of Patent: August 6, 2013
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Heinz-Michael Hein, Emad Sarofim, Lotar Schenk, Hans-Peter Wahl
  • Patent number: 8492161
    Abstract: Disclosed is a method for quantitatively analyzing a functional group on the surface of a solid material. The functional group is carboxylic group while the solid material is carbon nano-tubes. The carboxylic group reacts with sodium hydrogen carbonate, thus turning the carboxylic groups into sodium carboxylate while consuming the sodium ions in the solution. The carbon nano-tubes are separated from the sodium hydrogen carbonate solution. The number of the sodium ions before and after the reaction is analyzed. Moreover, the sodium carboxylate carried on the reacted carbon nano-tubes with reacts with hydrochloric acid solution, thus dissolving the sodium ions in the hydrochloric acid solution. The carbon nanotubes are separated from from the hydrochloric acid solution. The amount of the sodium ions is analyzed before and after the reaction in the hydrochloric acid solution.
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: July 23, 2013
    Assignee: Atomic Energy Council—Institute of Nuclear Energy Research
    Inventors: Meng-Jun Fu, Kuan-Yin Chen, Chia-Chieh Chen
  • Patent number: 8491501
    Abstract: A fluid handling module that is removably engageable with a bodily fluid analyzer is provided. The module may comprise a fluid handling element, and a fluid component separator that is accessible via the fluid handling element and configured to separate at least one component of a bodily fluid transported to the fluid component separator. The fluid handling element may have at least one control element interface.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: July 23, 2013
    Assignee: Optiscan Biomedical Corporation
    Inventors: Jennifer H. Gable, James R. Braig, Kenneth I. Li, Mark Wechsler, Peng Zheng, Richard Keenan
  • Patent number: 8492157
    Abstract: A microfluidic device and a method for measurement of biomaterials using the same. The microfluidic device includes a microfluidic structure including: a sample chamber which receives and accommodates blood; a reagent chamber which contains a luminescent reactant; a first detection chamber which contains a first material that is positively charged; a second detection chamber which is connected to the first detection chamber, and contains a second material having a boronate moiety; and at least one channel which connects the sample chamber, the reagent chamber and the first and second detection chambers.
    Type: Grant
    Filed: November 11, 2011
    Date of Patent: July 23, 2013
    Assignees: Samsung Electronics Co., Ltd., Industry-Academic Cooperation Foundation, Yonsei University
    Inventors: Jong Myeon Park, Won Yong Lee, Han Nim Choi, Jung Hoon Lee
  • Patent number: 8486335
    Abstract: An automated microscope slide staining system and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments or a pressurizable common chamber for individually and independently processing a plurality of microscope slides. The apparatus preferably features independently movable slide support elements each having an individually operable heating element.
    Type: Grant
    Filed: August 28, 2009
    Date of Patent: July 16, 2013
    Inventor: Lee H. Angros
  • Patent number: 8486336
    Abstract: A microchip including a fluid circuit formed by a groove of a first substrate and a surface of a second substrate is provided. The fluid circuit includes a fluid retaining reservoir for containing a fluid. The fluid retaining reservoir includes a fluid outlet or outflow channel for allowing the fluid to flow out, and a partition dividing the fluid retaining reservoir into a first region including a fluid inlet for injecting a fluid into the fluid retaining reservoir and a second region including the fluid outlet or outflow channel. The partition includes at least one communication gate for allowing communication between the first region and the second region.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: July 16, 2013
    Assignee: Rohm Co., Ltd.
    Inventors: Yasuhisa Kageyama, Youichi Aoki
  • Patent number: 8481326
    Abstract: A microfluidic device and method for measuring a level of cholesterol therewith are provided. The cholesterol measurement apparatus includes a microfluidic device including a plurality of chambers and at least one channel through which the plurality of chambers are interconnected. The plurality of chambers include a reaction chamber which contains a capture binder, a buffer chamber which contains an elution buffer and is connected to the reaction chamber, and at least one detection chamber which contains a cholesterol measurement reagent and is connected to the reaction chamber.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: July 9, 2013
    Assignee: Samsung Electronics Co., Ltd.
    Inventor: In Wook Kim