Utilizing A Centrifuge Or Compartmented Rotor Patents (Class 436/45)
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Patent number: 7943386Abstract: An apparatus for determining the volume fractions of the phases in a suspension includes a body, a channel structure, which is formed in the body, and an inlet area and a blind channel, which is fluidically connected to and capable of being filled via the same. Furthermore, a drive for imparting the body with rotation, so that phase separation of the suspension in the blind channel takes place, is provided. The blind channel includes such a channel cross-section and/or such wetting properties that, when filling same via the inlet area, higher capillary forces act in a first cross-sectional area than in a second cross-sectional area, so that at first the first cross-sectional area fills in the direction from the inlet area toward the blind end of the blind channel and then the second cross-sectional area fills in the direction from the blind end toward the inlet area.Type: GrantFiled: October 5, 2006Date of Patent: May 17, 2011Assignee: Albert-Ludwigs-Universitaet FreiburgInventors: Markus Grumann, Jens Ducrée, Roland Zengerle, Lutz Riegger
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Patent number: 7935534Abstract: Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed position, and the reagent, wash and coverslipping solutions brought to the slides. Alternatively, the slides are held in fixed position, while the reagent, wash and coverslipping solutions brought to the slides.Type: GrantFiled: June 18, 2010Date of Patent: May 3, 2011Assignee: Ventana Medical Systems, Inc.Inventors: Charles Lemme, Devon Campbell, Andrew Ghusson, David Bryant, Kurt Reinhardt, William Richards, Vincent Rizzo, Wayne Showalter
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Patent number: 7906336Abstract: A sensor dispensing instrument adapted to handle a sensor pack containing a plurality of sensors and to perform a test using one of the sensors. The sensor dispensing instrument includes an outer housing and a mechanical mechanism contained therein for rotating the sensor pack and ejecting one of the sensors from the sensor pack and through a sensor slot on the housing. The sensor dispensing instrument also includes a sensor actuator to engage with a sensor disposed in the sensor slot, and a sensor release that is movable to disengage the sensor actuator from the sensor disposed in the sensor slot and permit the discharge of the sensor.Type: GrantFiled: August 10, 2009Date of Patent: March 15, 2011Assignee: Bayer HealthCare LLCInventors: Robert C. Whitson, Russell J. Micinski
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Patent number: 7907985Abstract: A fluid handling module that is removably engageable with a bodily fluid analyzer is provided. The module may comprise a fluid handling element, and a fluid component separator that is accessible via the fluid handling element and configured to separate at least one component of a bodily fluid transported to the fluid component separator. The fluid handling element may have at least one control element interface.Type: GrantFiled: December 21, 2005Date of Patent: March 15, 2011Assignee: Optiscan Biomedical CorporationInventors: Jennifer H. Gable, James R. Braig, Kenneth I. Li, Mark Wechsler, Peng Zheng, Richard Keenan
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Publication number: 20110053202Abstract: An analytical system for performing centrifugal analysis on a working fluid with different components includes a uniform-dividing unit with a reduced cross section to divide the working fluid, a separating unit connected to the uniform-dividing unit, and a detecting unit. The detecting unit includes a detection compartment and a constant-quantity region connected to the separating unit through a separation channel. When rotating the uniform-dividing unit, the working fluid located at the uniform-dividing unit is transmitted to and separated by the separating unit, thereby causing one component of the working fluid to be separated from the other component and transmitted to the detection compartment through the constant-quantity region. With constant-quantity region, the detection compartment can be prevented from flushing by the excess of the separated component, and thus yield of product detection can be increased and different assays detection is carried out with a small sample volume at the same time.Type: ApplicationFiled: December 9, 2009Publication date: March 3, 2011Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Shaw-Hwa Parng, Chung-Hsien Tsai, Fu-Chun Huang, Chih-Wen Yang
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Patent number: 7897398Abstract: A device for analysis used for transferring a solution to a measurement spot 38 by a centrifugal force and reading in which a reaction liquid located at the measurement spot 38 is optically accessed. An operation cavity 30 and a receiving cavity 32 are arranged from the upstream side to the downstream side of the transfer. The operation cavity 30 and the receiving cavity 32 communicate with each other via a connection section 59 to transfer the solution of the operation cavity 30 to the receiving cavity 32. The connection section 59 is located inside the liquid level of a diluted solution retained in the operation cavity 30, relative to a rotation axis 102.Type: GrantFiled: July 25, 2008Date of Patent: March 1, 2011Assignee: Panasonic CorporationInventor: Hiroshi Saiki
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Patent number: 7897106Abstract: Contemplated herein is an automated microscope slide antigen recovery and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments for individually and independently processing a plurality of individual microscope slides. The apparatus preferably features independently movable slide support elements each having an individually heatable heating plate. Each slide support element preferably supports a single microscope slide. Each microscope slide can be enclosed within an individual pressurizable reaction compartment. Pressures exceeding 1 atm or below 1 atm can be created and maintained in the reaction compartment prior to, during or after heating of the slide begins.Type: GrantFiled: May 24, 2006Date of Patent: March 1, 2011Inventors: Lee Angros, Thomas Lee Byers
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Patent number: 7892856Abstract: Inventive methods and apparatus are useful for collecting magnetic materials in one or more magnetic fields and resuspending the particles into a dispersion medium, and optionally repeating collection/resuspension one or more times in the same or a different medium, by controlling the direction and rate of fluid flow through a fluid flow path. The methods provide for contacting derivatized particles with test samples and reagents, removal of excess reagent, washing of magnetic material, and resuspension for analysis, among other uses. The methods are applicable to a wide variety of chemical and biological materials that are susceptible to magnetic labeling, including, for example, cells, viruses, oligonucleotides, proteins, hormones, receptor-ligand complexes, environmental contaminants and the like.Type: GrantFiled: December 26, 2006Date of Patent: February 22, 2011Assignee: Battelle Memorial InstituteInventors: Jay W. Grate, Cynthia J. Bruckner-Lea, David A. Holman
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Patent number: 7867767Abstract: Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser.Type: GrantFiled: April 6, 2009Date of Patent: January 11, 2011Assignee: 3M Innovative Properties CompanyInventors: William Bedingham, Peter D. Ludowise, Barry W. Robole
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Patent number: 7867443Abstract: The present invention concerns a method and apparatus for automatic staining or other processing of a biological sample on a slide, perhaps robotically, by applying predetermined amounts of reagents in a predetermined sequence according to a processing protocol, the processing including pre-treatment steps, under the control of an adaptive processing control system. Further provided is a method of antigen retrieval, the method comprising contacting, within a heated processing tank of an automated staining apparatus, at least one biological sample with at least one composition for antigen retrieval comprising at least one chelating agent, at least one detergent and at least 50% by volume of at least one liquid that facilitates antigen retrieval.Type: GrantFiled: July 7, 2005Date of Patent: January 11, 2011Assignee: DAKO Denmark A/SInventors: Marc E. Key, Scott A. Devore, Loren L. Bland, Uffe Lovborg
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Patent number: 7854893Abstract: An analysis device comprises a separation chamber for separating a sample solution into a solution component and a solid component, a holding channel, a mixing chamber connected to the holding channel, an overflow channel connected between the holding channel and the separation chamber, a sample overflow chamber into which the sample solution remaining in the separation chamber is discharged, and a joint channel connecting the separation chamber and the sample overflow chamber. After the separated solution component fills the overflow channel with priority, the separated solid component is transferred to the holding channel via the overflow channel, and a predetermined amount of the solid component is measured. The solid component in the holding channel is transferred to the mixing chamber by a centrifugal force, and simultaneously, the sample solution remaining in the separation chamber is discharged to the sample overflow chamber by the siphon effect of the joint channel.Type: GrantFiled: March 28, 2008Date of Patent: December 21, 2010Assignee: Panasonic CorporationInventors: Hiroshi Saiki, Masanori Tanaka
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Patent number: 7846394Abstract: Embodiments of the present invention provide an apparatus and a method for separating particles within a sample. The apparatus includes a reservoir for receiving a biological specimen therein, wherein the specimen includes a plurality of different sized particles in a liquid. At least one physical state of the specimen is capable of being controlled in order to initially separate at least a first type of particles under the influence of gravity. The apparatus also includes a rotatable disk positioned proximate to the reservoir and configured to receive the first type of particles thereon. The disk has holes defined therethrough that are configured to further separate the first type of particles based on particle size.Type: GrantFiled: October 2, 2007Date of Patent: December 7, 2010Assignee: Becton, Dickinson and CompanyInventor: Nicholas R. Bachur, Jr.
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Patent number: 7824915Abstract: The invention provides a small-sized automatic analyzer being compact, enabling a large number of analysis items to be carried out, and having a high processing speed. The automatic analyzer is particularly suitably applied to a medical analyzer used for qualitative/quantitative analysis of living body samples, such as urine and blood. A plurality of sample dispensing mechanism s capable of being operated independently of each other are provided to suck a sample from any one of a plurality of sample suction positions and to discharge the sucked sample to any one of a plurality of positions on a reaction disk. The automatic analyzer having a high processing capability can be thus realized without increasing the system size.Type: GrantFiled: February 19, 2004Date of Patent: November 2, 2010Assignee: Hitachi, Ltd.Inventors: Hideyuki Yanami, Isao Yamazaki, Masaaki Hanawa, Hitoshi Otake
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Publication number: 20100255589Abstract: A capillary cavity 19 and an inlet 13 protruding circumferentially outward from an axial center 107 are connected by a guide section 17 formed so as to extend circumferentially inward and on which a capillary force acts. A sample liquid collected from a leading end of the inlet 13 is transferred to a separation cavity 23. A bent section 22 and a recess 21 are formed at a connected section of the guide section 17 and the capillary cavity 19 so as to change the direction of a passage.Type: ApplicationFiled: October 28, 2008Publication date: October 7, 2010Applicant: PANASONIC CORPORATIONInventors: Hiroshi Saiki, Tomohiro Kijima, Kouzou Tagashira, Masahito Shiraishi, Hirofumi Sugimoto, Kenji Okada
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Patent number: 7790468Abstract: A test object receptacle, capable of measuring a test object in a wide range of concentrations with good accuracy and within a short time, contains a plurality of fine protruding portions inside grooves. The test object receptacle can fix antigens, antibodies and test objects faster than without the protruding portions. Furthermore, the protruding portions are so formed that the surface area thereof increases gradually to the downstream with respect to the movement direction of the test object in the grooves, the detection intensity (intensity of color development) of the test object is not saturated downstream of the grooves even when the test object has a high concentration. For this reason, the test object can be detected within a short time and the measurements can be conducted within a wide concentration range.Type: GrantFiled: March 4, 2005Date of Patent: September 7, 2010Assignee: Brother Kogyo Kabushiki KaishaInventors: Chisato Yoshimura, Hideo Nakano, Takanori Ishishika
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Patent number: 7790110Abstract: Provided is a microfluidic device that can automatically perform various types of biological blood analysis. In the microfluidic device, a specimen is centrifugally separated and the centrifugally separated specimen is diluted into various dilution ratios. Also, at least two reagents that are required for one reaction and that need to be separately stored are stored in separate chambers, and they are mixed when a reaction is needed. Thus, various conventional blood analyzing reagents can be used as they are or after being minimally processed in the microfluidic device.Type: GrantFiled: June 26, 2008Date of Patent: September 7, 2010Assignee: Samsung Electronics Co., Ltd.Inventors: Yoon-kyoung Cho, Do-gyoon Kim, Jung-nam Lee, Hee-kyun Lim
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Patent number: 7785534Abstract: An automatic analyzer is disclosed that has a structure capable of using reagent containers each having an ID, such as a barcode, attached either on the top surface or the undersurface thereof, or alternatively on each of them. This automatic analyzer, therefore, allows information about the reagent ID to be read or written at an arbitrary timing even if the mounting density of reagent containers of the automatic analyzer is increased, thereby improving the function and performance of the apparatus.Type: GrantFiled: June 22, 2004Date of Patent: August 31, 2010Assignee: Hitachi High-Technologies CorporationInventor: Shigenori Watari
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Patent number: 7763467Abstract: A drip shield includes cover members that define a protective canopy over sample receptacles to prevent unwanted material from being deposited into the receptacles. The cover members cooperate to define at least one access hole through the drip shield to permit access to a sample receptacle by a pipette tip through the access hole. One of the cover members is moveable with respect to another cover member between a closed stated defining the access hole and an open state permitting a pipette tip extending through the access hole to be laterally conveyed relative to the drip shield and out of the access hole.Type: GrantFiled: February 12, 2007Date of Patent: July 27, 2010Assignee: Gen-Probe IncorporatedInventor: Byron J. Knight
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Publication number: 20100184228Abstract: A device for analysis used for transferring a solution to a measurement spot 38 by a centrifugal force and reading in which a reaction liquid located at the measurement spot 38 is optically accessed. An operation cavity 30 and a receiving cavity 32 are arranged from the upstream side to the downstream side of the transfer. The operation cavity 30 and the receiving cavity 32 communicate with each other via a connection section 59 to transfer the solution of the operation cavity 30 to the receiving cavity 32. The connection section 59 is located inside the liquid level of a diluted solution retained in the operation cavity 30, relative to a rotation axis 102.Type: ApplicationFiled: July 25, 2008Publication date: July 22, 2010Applicant: PANASONIC CORPORATIONInventor: Hiroshi Saiki
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Patent number: 7754151Abstract: Herein disclosed is a liquid homogenizer for mixing two or more liquids, comprising: a rotator (1) rotatable around a rotation axis; at least two liquid-mixing chambers (6, 10) formed in the rotator, and being different from each other in distance from the rotation axis; and at least two channels (8) through which one of the liquid-mixing chambers is communicated with the other of the liquid-mixing chambers (6, 10), wherein the liquid-mixing chambers (6, 10) include an outer liquid-mixing chamber (10) and an inner liquid-mixing chamber (6) close to the rotation axis in comparison with the outer liquid-mixing chamber, when the rotator (1) is rotating around the rotation axis, the liquids are shifted by a centrifugal force to the outer liquid-mixing chamber from the inner liquid-mixing chamber through the channels (8), and agitated to be mixed by turbulent flows in the outer liquid-mixing chamber.Type: GrantFiled: March 24, 2006Date of Patent: July 13, 2010Assignee: Panasonic CorporationInventors: Fumihisa Kitawaki, Hirotaka Tanaka, Kenji Watanabe
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Patent number: 7749441Abstract: An automatic analyzer is disclosed that dispenses a sample and a reagent into each of a plurality of reaction vessels to allow them to react with each other, and that measures the liquid formed as a result of the reaction. This automatic analyzer includes a first reagent storage case for storing the reagent to be used for the reaction, a second reagent storage case for storing the reagent for supplemental purpose, and a reagent conveying unit for conveying the reagent from the second reagent storage case to the first reagent storage case.Type: GrantFiled: July 15, 2004Date of Patent: July 6, 2010Assignees: Hitachi High-Technologies Corporation, Roche Diagnostics Operations, Inc.Inventors: Masaaki Hanawa, Isao Yamazaki, Hitoshi Tokieda, Masaharu Nishida, Masaki Shiba, Heino Eikmeier, Dietmar Kappelhoff, Christoph Möllers, Stephan Sattler
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Patent number: 7737093Abstract: A device is provided that can include at least one gas trap that can be arranged in fluid communication with a sample-containment feature formed in or on the device. The gas trap can be arranged to trap gas or air displaced from the sample-containment feature as the sample-containment feature is loaded with a liquid. The trapped gas in the gas trap can assist in breaking-up and expelling the liquid from the sample-containment feature during a subsequent liquid transfer operation, for example, to an adjacent sample-containment feature. Systems for processing such a device and methods using such a device are also provided.Type: GrantFiled: October 7, 2008Date of Patent: June 15, 2010Assignee: Applied Biosystems, LLCInventor: David M. Cox
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Patent number: 7732212Abstract: A communication unit (12) of a service center (10) transmits and receives information such as analysis information to and from a plurality of automatically analyzing apparatuses (100). A database (16) stores the information such as the analysis information. An analysis information parsing unit (14) evaluates and parses results of analyses made by the automatically analyzing apparatuses using the analysis information stored in the database. The reagent parameter registration unit (18) registers information on reagents in the database (16). The communication unit (12), responsive to a request from an automatically analyzing apparatus, retrieves information on analysis parameters related to managed reagents from the database for transfer to the automatically analyzing apparatus. In this way, analysis parameters can be readily set for a testing item to be analyzed using a reagent.Type: GrantFiled: March 3, 2000Date of Patent: June 8, 2010Assignee: Hitachi, Ltd.Inventors: Shinpei Nakata, Takehiko Yotsugi, Hiroaki Ishizawa
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Patent number: 7731898Abstract: A reagent container assembly adapted for being installed in a cavity of an analyzer. The reagent container assembly comprises a housing having an upper opening and defining at least one circular array of chambers, each chamber being adapted for receiving a reagent container, a cover for closing the upper opening of the housing, and a locking mechanism arranged within the housing. The locking mechanism is adapted for locking the cover and for preventing rotation thereof. The locking mechanism is further adapted for locking the housing and thereby preventing rotation thereof when the reagent container assembly is removed from its position in the analyzer. The locking mechanism is further adapted for cooperating with a pin arranged at the bottom of the cavity of the analyzer when the reagent container assembly is installed in the analyzer, the housing being unlocked by the cooperation and thereby allowed to be rotated within the cavity of the analyzer.Type: GrantFiled: September 20, 2006Date of Patent: June 8, 2010Assignee: Roche Diagnostics Operations, Inc.Inventors: Claudius Burkhardt, Gottlieb Schacher, Renato Belz
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Patent number: 7727472Abstract: A chemical analysis apparatus comprises a motor, a holding disk that can be rotated by the motor, a plurality of examination cartridges arranged on the holding disk, a perforator that perforates the examination cartridges, a heating device, and a detection device. The examination cartridge comprises a substrate including a vessel and a flow channel, which are defined by recesses, and a cover that covers the vessel and the flow channel. A centrifugal force generated by rotation of the holding disk is made use of to move a solution from a vessel on an inner peripheral side relative to an axis of rotation to a vessel on an outer peripheral side relative to the axis of rotation through the flow channel.Type: GrantFiled: December 29, 2005Date of Patent: June 1, 2010Assignee: Hitachi High-Technologies CorporationInventors: Yoshihiro Nagaoka, Nobuyuki Maki, Noriyo Nishijima, Michihiro Saito, Hiroki Ihara
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Patent number: 7727469Abstract: In an automatic analyzer, when a sample is newly added, all sample barcodes on a sample disk are read. Immediately before dispensing it, second time reading is performed, and the result thereof is checked against that of the first time reading. A sample hand-contact preventing plate is provided above the reading position and dispensing position in order to prevent the sample from being exchanged after the second time reading. This hand-contact preventing plate has a damage-preventing configuration to protect a hand and fingers of an operator against a sampling probe.Type: GrantFiled: April 13, 2004Date of Patent: June 1, 2010Assignees: Hitachi High-Technologies Corporation, Hitachi Science Systems, Ltd.Inventors: Katsuaki Takahashi, Hiroshi Ohga, Masaharu Nishida
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Patent number: 7722812Abstract: A reaction disk provides a compact and inexpensive design of an automatic analyzer so that the constituents in a suspension, such as blood sampled from a patient at a sick room or other place in a hospital, can be analyzed immediately and quantitatively. A separation cell and a determination cell are formed in a same reaction disk so as to maintain an upright position even during rotation of the both cells. The separation cell is formed to prevent poured suspension therein from flowing out during centrifugal separation, and a supernatant separated by centrifugation from the suspension contained in the separation cell is dispensed to the determination cell to analyze a target substance in the supernatant.Type: GrantFiled: December 7, 2004Date of Patent: May 25, 2010Assignee: Wako Pure Chemical Industries, Ltd.Inventors: Kazuhito Tanimoto, Keiko Sasaki, Masayoshi Hayashi, Hishiri Komiyama
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Patent number: 7718435Abstract: This invention describes a cartridge pump and dispensing assembly for applications where cartridges containing liquid reagents are interchanged often. The cartridge pump has a reagent reservoir which directly empties into a metering chamber. A valve is at each end of the metering chamber. The two valves are aligned in the same direction so as to allow unidirectional liquid flow. The metering chamber is made of a compressible material, such as flexible tubing, so that when an external compression is applied to the chamber, the liquid contained therein is forcibly expelled. As the compression is removed, the metering chamber resumes its former shape and draws liquid into the chamber from the reagent reservoir. A dispensing assembly with electromechanical actuators for compression of the metering chamber and a sensor for sensing the amount of liquid contained within the reagent reservoir are also shown.Type: GrantFiled: October 31, 2000Date of Patent: May 18, 2010Assignee: DAKO Denmark A/SInventors: Steven A. Bogen, Herbert H. Loeffler
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Patent number: 7713708Abstract: An immunological or immunohematological assay system is disclosed that includes a filter vessel capable of containing an assay sample, an incubator, a sample separation system, an image acquisition system, and a robotic pipettor. The immunological assay system may also include a washer. Also disclosed is an immunological assay method that includes the steps of placing a immunological assay sample in a filter vessel, which includes a filter, adding testing reagents to the filter vessel, incubating the sample and reagent mixture in the filter vessel, separating the sample and reagent mixture in the filter vessel into components above and below the filter, and analyzing the filter vessel to determine the presence of interactions between the sample and reagents.Type: GrantFiled: February 27, 2007Date of Patent: May 11, 2010Assignee: Emory UniversityInventors: John D. Roback, Christopher D. Hillyer
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Patent number: 7678577Abstract: A corpuscle/plasma separating part is disposed at the lower end of the substrate, and a sensor part connected to the corpuscle/plasma separating part is disposed at the upper end of the substrate, with a calibration solution reservoir being disposed on the lower side of the sensor part, and a calibration solution waste reservoir being disposed on the upper side of the sensor part. A first centrifugal axis is located upper to the corpuscle fraction storing part and lower to the plasma fraction storing part of the corpuscle/plasma separating part, while a second centrifugal axis is located within or close to the sensor part. Conveyance and discharge of the calibration solution can be carried out by performing centrifugation around the first centrifugal axis which is distant from the sensor part at a low speed of rotation, so that the centrifugal force exerted on the sensors would be small.Type: GrantFiled: August 9, 2005Date of Patent: March 16, 2010Assignee: National Institute for Materials ScienceInventors: Yasuhiro Horiike, Akio Oki
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Patent number: 7678576Abstract: The invention provides a chemical analysis apparatus which easily agitates and warms up. A chemical analysis apparatus has a motor, a retaining disc which can be rotated by the motor, a plurality of inspection cartridges which are arranged on the retaining disc, a punching machine for punching the inspection cartridges, a warming apparatus and a detection apparatus. The inspection cartridge includes a container formed by a concave portion and a base plate having a flow path. A cover covering the container and the flow path is installed to the base plate. A liquid solution is moved to the container in an outer peripheral side with respect to a rotation axis from the container in an inner peripheral side with respect to the rotation axis via the flow path, by utilizing a centrifugal force generated on the basis of the rotation of the retaining disc.Type: GrantFiled: December 29, 2005Date of Patent: March 16, 2010Assignee: Hitachi High-Technologies CorporationInventors: Shigeyuki Sasaki, Yoshihiro Nagaoka, Noriyo Nishijima, Naruo Watanabe, Michihiro Saito, Taisaku Seino, Satoshi Takahashi
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Patent number: 7678330Abstract: The present invention seeks to provide an express-control system for analyzing the compatibility of blood with other substances. The present invention relates to a system, method and apparatus for use in blood testing and more specifically, food intolerance testing through analysis of blood using luminescence. The present invention utilizes a blood testing system and apparatus, which includes a displacement assembly, a blood divider assembly, a reagent divider assembly, an electro-optical multiplier assembly and a central controller. A sample of blood is added to a corresponding one of a plurality of canisters containing a test substance. Thereafter a luminescent reagent is added and the plurality of canisters are moved in the blood testing apparatus until the canisters begin to luminese.Type: GrantFiled: March 1, 2006Date of Patent: March 16, 2010Inventors: Aleksandr Ostrovsky, Mikhail Leibovski
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Patent number: 7666602Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next.Type: GrantFiled: October 25, 2007Date of Patent: February 23, 2010Assignee: Gen-Probe IncorporatedInventors: Kelly G. Ammann, Ernest V. Hansberry
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Patent number: 7666355Abstract: The present invention provides a bar-code driven, completely automated, microplate-based analyzer system for performing chemical, biochemical or biological assays. The analyzer is a modular, bench-top instrument that compactly integrates subsystems for sample dispensing, liquid handling, microplate transport, thermal incubation, vortexing, solid phase separation and optical reading. An internal processor is included for automating the instrument, and a user interface to facilitate communication with the operator via a touch-sensitive liquid-crystal display (LCD), and communicating with a remote network via multiple protocols. The analyzer includes firmware resident within the processing system and the user interface allows the operator to select pre-defined assay batch protocols and the user interface is configured in such as way so as to restrict an operator from programming the firmware.Type: GrantFiled: March 7, 2006Date of Patent: February 23, 2010Inventors: Tino Alavie, Keith Beckley, Andrew Hudson, Stephen W. Leonard, Robert Maaskant, Samad Talebpour, William Yang
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Patent number: 7666681Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next.Type: GrantFiled: May 23, 2005Date of Patent: February 23, 2010Assignee: Gen-Probe IncorporatedInventors: Kelly G. Ammann, Ernest V. Hansberry
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Patent number: 7662340Abstract: The invention is achieved by feeding a reagent using centrifugal force, without providing a valve for controlling the flow rate of the reagent in the reagent flow path. A chemical analyzer is used which comprises a structure that is supported so as to be rotatable, said structure comprising a capturing section for capturing specific chemical substances from a specimen, specimen containers and reagent containers including washing solution containers.Type: GrantFiled: December 28, 2001Date of Patent: February 16, 2010Assignee: Hitachi High-Technologies CorporationInventors: Yoshihiro Nagaoka, Naruo Watanabe, Teruhisa Akashi, Yuji Miyahara, Kei Takenaka, Tomoki Ohashi
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Patent number: 7663092Abstract: A phase contrast quadrature interferometric method and apparatus for determining the presence or absence of a target analyte in a sample. The method includes probing a substrate exposed to the sample with a laser beam. The substrate includes a reflecting surface with a first region having recognition molecules specific to the target analyte and a second region without recognition molecules. The method also includes probing the first and second region, and measuring time dependent intensity on a photodetector at one or both of a pair of quadrature angles of a reflected diffraction signal. The apparatus includes a laser source, a platform for receiving the planar array, an objective lens offset from the platform by approximately a focal length, and a split photodetector means for measuring a first quadrature and a second quadrature in a signal resulting from reflection of the laser beam.Type: GrantFiled: February 1, 2006Date of Patent: February 16, 2010Assignee: Purdue Research FoundationInventors: David D. Nolte, Leilei Peng, Fred E. Regnier, Ming Zhao
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Publication number: 20100015715Abstract: A microfluidic device and a method of transferring a liquid material using the microfluidic device are provided. The microfluidic device includes a chamber storing a sealed liquid material, and a structure that flows air to the chamber, when the structure is rotated to generate centrifugal force, so that the liquid material may be transferred from the chamber.Type: ApplicationFiled: July 8, 2009Publication date: January 21, 2010Applicant: Samsung Electronics Co., Ltd.Inventors: Yoonkyoung Cho, Jeonggun Lee, Beomseok Lee, Jongmyeon Park
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Patent number: 7638342Abstract: The present invention provides a method of analyzing plasma from a sample of whole blood. The method includes a) obtaining a sample of whole blood from a subject in a container, the container having a first end and a second end, the first end of the container for receiving a sample of whole blood; b) centrifuging the container under conditions to separate the whole blood into a cell layer, a gel layer and a plasma layer, wherein the centrifuging produces in relative juxtaposition the first end of the container, the cell layer, the gel layer, the plasma layer and the second end of the container; and c) inserting into a spectrophotometric device the second end of the container which includes the plasma layer in closest relative juxtaposition, to analyze the plasma from the whole blood.Type: GrantFiled: February 24, 2005Date of Patent: December 29, 2009Assignee: NIResults Inc.Inventor: James Samsoondar
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Patent number: 7638337Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next.Type: GrantFiled: October 30, 2007Date of Patent: December 29, 2009Assignee: Gen-Probe IncorporatedInventors: Kelly G. Ammann, Ernest V. Hansberry
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Patent number: 7632461Abstract: An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. Each treatment step occurs within the same reaction compartment. The reaction conditions of each reaction compartment for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide. The reagents are preferably held in a reagent dispensing strip similar to a “blister pack”.Type: GrantFiled: September 17, 2004Date of Patent: December 15, 2009Inventor: Lee Angros
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Patent number: 7629176Abstract: A tube and float system for use in separation and axial expansion of the buffy coat includes a transparent or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The float includes a main body portion of reduced diameter to provide a clearance gap between the inner wall of the sample tube and the float. One or more protrusions on the main body portion serve to support the flexible tube. During centrifugation, the centrifugal force causes the diameter of the flexible tube to expand and permit density-based axial movement of the float in the tube. The float further includes a pressure relief system to alleviate pressure build up in the trapped red blood cell blood fraction below the float, thereby preventing red blood cells from being forced into the annular gap containing the buffy coat layers.Type: GrantFiled: February 11, 2008Date of Patent: December 8, 2009Assignee: Battelle Memorial InstituteInventors: Thomas Haubert, Vince Contini, Steve Grimes, Randy Jones, Stephen C. Wardlaw
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Patent number: 7622077Abstract: An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. Each treatment step occurs within the same reaction compartment. The reaction conditions of each reaction compartment for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide. The reagents are preferably held in a reagent dispensing strip similar to a “blister pack”.Type: GrantFiled: September 17, 2004Date of Patent: November 24, 2009Inventor: Lee Angros
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Patent number: 7611899Abstract: A sensor dispensing instrument adapted to handle a sensor pack containing a plurality of sensors and to perform a test using one of the sensors. The sensor dispensing instrument includes an outer housing and a mechanical mechanism contained therein for rotating the sensor pack and ejecting one of the sensors from the sensor pack and through a sensor slot on the housing. The sensor dispensing instrument also includes a sensor actuator to engage with a sensor disposed in the sensor slot, and a sensor release that is movable to disengage the sensor actuator from the sensor disposed in the sensor slot and permit the discharge of the sensor.Type: GrantFiled: July 30, 2002Date of Patent: November 3, 2009Assignee: Bayer HealthCare LLCInventors: Robert C. Whitson, Russell J. Micinski
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Patent number: 7604776Abstract: A reaction of a sample mixture liquid is detected accurately, by allowing a solid reagent to be dissolved and reacted in a liquid sample quickly and accurately. A disc main body, and at least one sample mixing unit provided at the disc main body are provided, and the sample mixing unit is provided with: a liquid sample reserve unit; a reagent chamber capable of disposing a plurality of the solid reagents; and a measurement chamber to which a sample mixture liquid containing a liquid sample and a solid reagent mixed in the reagent chamber is supplied. The reagent chamber has a form which allows a plurality of the solid reagents to be disposed in the direction substantially parallel to the radial direction of the disc in which centrifugal force is generated, or in the direction substantially perpendicular to the radial direction of the disc.Type: GrantFiled: May 1, 2008Date of Patent: October 20, 2009Assignee: Panasonic CorporationInventors: Tomohiro Yamamoto, Toshihiko Yoshioka, Nobuhiko Ozaki
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Patent number: 7597847Abstract: An analyzer, preferably a desktop analyzer, includes: a stationary probe capable of dispensing or aspirating a liquid; one or more of a movable test element or movable liquid source; and a conveyor for moving the movable test element or liquid source with respect to the stationary probe. In a preferred embodiment, the conveyor includes a dual rotor conveyor. A method of dispensing or aspirating a liquid into a test element includes: providing a movable test element having identifying marks, such as a barcode, thereon and a movable sample liquid supply; providing a stationary probe; reading the identifying marks to determine which test is to be performed and the dimensions of the test element; moving the movable sample liquid supply into registration with the probe; aspirating sample into the stationary probe; and moving the movable test element into registration with the probe, wherein the registration of the test element with the probe is controlled by the test to be performed.Type: GrantFiled: March 31, 2003Date of Patent: October 6, 2009Assignee: Ortho-Clinical Diagnostics, Inc.Inventors: David Angelo Tomasso, Raymond Francis Jakubowicz, James Vanselow Barry
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Patent number: 7593787Abstract: Systems and methods allowing for the automatic control and scheduling of a staining apparatus for biological samples on slides present within the apparatus are provided. In some embodiments, the actions of a robot coupled to the staining apparatus, which performs some of the staining tasks on the individual slides in accordance with their respective protocols, may be prioritized and scheduled. In some embodiments, the scheduling may result in increasing or maximizing the throughput of slides. In some embodiments, robot scheduling ensures that the individual slides are processed substantially within the tolerances specified by their respective protocols. In some embodiments, the robot scheduler may respond to spontaneous user actions and adaptively schedule or re-schedule robot actions.Type: GrantFiled: January 23, 2006Date of Patent: September 22, 2009Assignee: Dako Denmark A/SInventors: Gordon Alan Feingold, James B. Gilmartin, Mark Richard Holbrook, John A. Favuzzi, Marc E. Key
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Patent number: 7569186Abstract: Sample processing systems for processing sample materials located in sample processing devices that are separate from the system are disclosed. The sample processing systems include a rotating base plate with raised and/or non-planar thermal structures on which the sample processing devices are located during operation of the systems. The systems may also include structure to urge the sample processing devices against the base plate and thermal structures.Type: GrantFiled: March 16, 2005Date of Patent: August 4, 2009Assignee: 3M Innovative Properties CompanyInventors: William Bedingham, James E. Aysta, Barry W. Robole
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Patent number: 7560071Abstract: An automated testing system includes one or more laboratory devices that operate together to perform an assay. The testing system is designed such that a laboratory device may be seamlessly integrated with the remaining devices in a quick and effortless manner. Specifically, the laboratory device is securely mounted on a slidable cart with fluid and electrical connections established therebetween. The slidable cart is in turn adapted to releasably engage with a docking station that is fixedly mounted on the workspace floor, the docking station being provided with at least one fluid input connection, an input power connection and at least one communication signal connection that are relatively permanent in nature. In order to couple the cart to the docking station, the cart is rolled generally into position above the docking station using complementary alignment posts and tracks.Type: GrantFiled: March 29, 2006Date of Patent: July 14, 2009Inventors: Michael J. Nichols, Louis J. Guarracina
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Patent number: 7553671Abstract: Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.Type: GrantFiled: May 25, 2004Date of Patent: June 30, 2009Assignee: Vertex Pharmaceuticals, Inc.Inventors: James E. Sinclair, Brian Grot