Glass Or Silica Patents (Class 436/527)
  • Patent number: 10155776
    Abstract: The Invention relates to a novel receptor molecule for estimation of amino acids based on florescence enhancements. Particularly, the invention relates to a novel Cu (II)-complex as a turn-on luminescence probe for selective detection of cysteine and histidine in pure aqueous environment and in biological sample as well as for detection of cyanide ions among various anions under physiological conditions.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: December 18, 2018
    Assignee: Council of Scientific and Industrial Research
    Inventors: Amitava Das, Samit Chattopadhyay, Upendar Reddy Gandra, Hridesh Agarwalla
  • Patent number: 10010268
    Abstract: Provided is an endoscope apparatus for measuring a subject. The endoscope apparatus including: an elongated insertion unit; an image capturing unit being provided on a distal end part of the insertion unit, the image capturing unit configured to obtain an image of the subject; an illumination unit comprising a first light source and configured to illuminate an observation viewing field of the image capturing unit; and a fringe projection unit comprising a second light source configured to emit a light, which differs from a light of the first light source, and a fringe pattern generation unit configured to form the fringe pattern, and configured to project the fringe pattern on the subject.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: July 3, 2018
    Assignee: OLYMPUS CORPORATION
    Inventor: Masayoshi Yokota
  • Patent number: 9795961
    Abstract: Embodiments of the present invention are directed toward devices, systems, and method for conducting nucleic acid purification and quantification using sedimentation. In one example, a method includes generating complexes which bind to a plurality of beads in a fluid sample, individual ones of the complexes comprising a nucleic acid molecule such as DNA or RNA and a labeling agent. The plurality of beads including the complexes may be transported through a density media, wherein the density media has a density lower than a density of the beads and higher than a density of the fluid sample, and wherein the transporting occurs, at least in part, by sedimentation. Signal may be detected from the labeling agents of the complexes.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: October 24, 2017
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Chung-Yan Koh, Ulrich Y. Schaff, Gregory J. Sommer
  • Patent number: 9786398
    Abstract: A nanocomposite solid material includes nanoparticles of a metal coordination polymer with CN ligands comprising Mn+ cations, in which M is a transition metal and n is 2 or 3; and anions [M?(CN)m]x? in which M? is a transition metal, x is 3 or 4, and m is 6 or 8. The Mn+ cations of the coordination polymer are bound through an organometallic bond to an organic group of an organic graft chemically attached inside the pores of a support made of porous glass. The material can be used in a method for fixing (binding) a mineral pollutant, such as radioactive cesium, contained in a solution by bringing the solution in contact with the nanocomposite solid material.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: October 10, 2017
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE MONTPELLER II
    Inventors: Agnes Grandjean, Yves Barre, Yannick Guari, Joulia Larionova, Christian Guerin
  • Patent number: 9279914
    Abstract: A condensing lens, compound-eye lens condenser, and compound-eye concentrating-type solar cell assembly. The condensing lens is a convex lens that can reflect mutually parallel incident lights (3) onto a receiving surface (4) on the outer side of the lens and thus form spots. If the vertical distance from the contact point of any incident lights (3) contacting the lens to a light axis (103) of the lens is x, the vertical distance between a projection point formed from the incident light (3) reflecting onto the receiving surface (4) and the center of the spot is m, the radius of the lens is a, and the radius of the spot is b, then the lens meets the following condition: x/m=a/b. The condensing lens has a high transmission rate, and the energy distribution of the spots is more even after condensing, the transmission rate is 90% to 93%, and the energy distribution curve of the spots transmitted through the condensing lens is similar to saddle-shaped.
    Type: Grant
    Filed: August 15, 2011
    Date of Patent: March 8, 2016
    Assignee: CHENGDU ZSUN SCIENCE AND TECHNOLOGY DEVELOPING CO., LTD.
    Inventors: Zhong Huang, Han Liu, Shaochun Li
  • Patent number: 9023659
    Abstract: Disclosed is a quantum dot-embedded silica nanoparticle having plural quantum dots embedded within the silica nanoparticle, wherein the number of quantum dots existing in a concentric area within 10% of a radius from a center of the silica nanoparticle accounts for 10 to 70% of the number of total quantum dots embedded in the silica nanoparticle.
    Type: Grant
    Filed: March 1, 2010
    Date of Patent: May 5, 2015
    Assignee: Konica Minolta Medical & Graphic, Inc.
    Inventors: Takuji Aimiya, Masaru Takahashi
  • Patent number: 8993345
    Abstract: A method of producing functional molecule-containing silica nanoparticles on which a biomolecule is bonded, containing the steps of: allowing silica nanoparticles containing a functional molecule and having a thiol group on a surface thereof to coexist with a linker molecule having a maleimido group and a carboxyl group in an aprotic solvent, thereby allowing formation of a thioether bond between the thiol group and the maleimido group, and obtaining functional molecule-containing silica nanoparticles on which the linker molecule is bonded; and allowing the functional molecule-containing silica nanoparticles on which the linker molecule is bonded to coexist with carbodiimide and a biomolecule having an amino group in an aqueous solvent, thereby allowing formation of an amide bond between the carboxyl group active esterified by the carbodiimide, and the amino group of the biomolecule.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: March 31, 2015
    Assignee: Furukawa Electric Co., Ltd.
    Inventors: Hideki Aizawa, Michio Ohkubo, Masataka Nishida
  • Patent number: 8987003
    Abstract: A biosensor device (100) for detecting biological particles, the biosensor device (100) comprising an electromagnetic radiation transmitting member (102) adapted for transmitting electromagnetic radiation and a plurality of sensor active structures (104) arranged at the electromagnetic radiation transmitting member (102), wherein each of the plurality of sensor active structures (104) is sensitive to specific biological particles and is adapted to modify electromagnetic radiation transmission properties of the electromagnetic radiation transmitting member (102) in the event of the presence of the respective biological particles, and wherein the electromagnetic radiation transmitting member (102) is adapted for a simultaneous detection of different biological particles at different ones of the plurality of sensor active structures (104).
    Type: Grant
    Filed: November 4, 2008
    Date of Patent: March 24, 2015
    Assignee: NXP B.V.
    Inventor: Pablo Garcia Tello
  • Patent number: 8959984
    Abstract: This invention relates to methods for the evaluation and/or quantification of the binding affinity of small molecules or other compounds to target components contained within an analyte, such as target proteins contained within the proteome of a cell or tissue.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: February 24, 2015
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften E.V.
    Inventors: Henrik Daub, Michaela Bairlein, Kirti Sharma, Klaus Godl, Andreas Tebbe, Christoph Weber
  • Patent number: 8940538
    Abstract: The present invention relates to an apparatus for quantifying the binding and dissociation kinetics of molecular interactions of small molecular bio materials with high sensitivity almost without the influence of a change in the reflective index resulting from a buffer solution by making polarized incident light incident on the binding layer of a bio material, formed in a thin dielectric film, so that the polarized incident light satisfies a p-wave non-reflecting condition and a quantifying method using the same.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: January 27, 2015
    Assignee: Korea Research Institute of Standards and Science
    Inventors: Hyun Mo Cho, Gal Won Che, Yong Jai Cho
  • Patent number: 8940478
    Abstract: Methods for forming cell arrays of multiple cell samples arranged substantially in a monolayer on a single substrate particularly suited for diagnostic analysis are disclosed. The cell arrays are formed with a high-speed dispensing apparatus capable of dispensing small volumes in precise, complex patterns. Also disclosed are substrates upon which cell arrays may be formed, and methods for conducting diagnostic analyzes on the formed cell arrays.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: January 27, 2015
    Assignees: Accupath Diagnostic Laboratories, Inc., Biodot, Inc.
    Inventors: Mathew Moore, Miriam Reyes, David Baunoch, Thomas C. Tisone, Brendan O'Farrell
  • Patent number: 8940143
    Abstract: An embodiment of the invention relates to a biochip comprising at least two measurement electrodes, a synthesis electrode, a ground electrode, a gap between the at least two measurement electrodes, a porous dielectric isolation layer and a gel comprising a probe in the gap, wherein the porous dielectric isolation layer is between the synthesis electrode and the gel. Yet other embodiments relate to the method of manufacturing the biochip and using the biochip for electrical detection of bio-species.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: January 27, 2015
    Assignee: Intel Corporation
    Inventors: Valery M. Dubin, Nikolay Suetin
  • Patent number: 8940548
    Abstract: A method for sensing biomolecules in an electrolyte includes exposing a gate dielectric surface of a sensor comprising a silicon fin to the electrolyte, wherein the gate dielectric surface comprises a dielectric material and antibodies configured to bind with the biomolecules; applying a gate voltage to an electrode immersed in the electrolyte; and measuring a change in a drain current flowing in the silicon fin; and determining an amount of the biomolecules that are present in the electrolyte based on the change in the drain current.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: January 27, 2015
    Assignee: International Business Machines Corporation
    Inventors: Marwan H. Khater, Tak H. Ning, Lidija Sekaric, Sufi Zafar
  • Patent number: 8809005
    Abstract: A composition comprising a conjugate of an anti-idiotype antibody specifically binding to a CDR region of a parent antibody and method of using polyclonal human serum immunoglobulin of class E, G, M, or A, and the use of said composition as a standard in an immunoassay is presented.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: August 19, 2014
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Kay-Gunnar Stubenrauch, Rudolf Vogel, Uwe Wessels
  • Patent number: 8802024
    Abstract: A method for manufacturing a biochip is provided. First, a first self-assembled monolayer is coated on a substrate. Next, a plurality of first biomedical molecular dots are formed on the first self-assembled monolayer by micro-titration technique. After the bonding reaction between the first biomedical molecular point and the first self-assembled monolayer, a second self-assembled monolayer is deposited on the surface of the first self-assembled monolayer by evaporation. The second self-assembled monolayer attached on the plurality of first biomedical molecular dots and the first self-assembled monolayer not bonded to the substrate are removed, so that the first biomedical molecular dots immobilized on the first self-assembled monolayer are exposed. Finally, a second biomedical molecular layer is immobilized on the exposed portions of the first biomedical molecular dots.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: August 12, 2014
    Assignee: National Tsing Hua University
    Inventors: Fan Gang Tseng, Hsin Yi Hsieh, Chun Lung Wu
  • Patent number: 8796012
    Abstract: A technique for high sensitivity evanescent field molecular sensing employs a detection scheme that simultaneously couples a polarized beam to a single mode of a waveguide, and couples the polarized beam out of the waveguide to specularly reflect the beam by the same grating. Strong interaction with the single (preferably TM) mode is provided by using a silicon on insulator (SOI) wafer having a waveguide thickness chosen between 10-400 nm so that the majority of the mode field strength spans the evanescent field. Well known, robust techniques for producing a grating on the waveguide are provided. Interrogation from a backside of the SOI wafer is taught.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: August 5, 2014
    Assignee: National Research Council of Canada
    Inventors: Bill Sinclair, Jens Schmid, Philip Waldron, Dan-Xia Xu, Adam Densmore, Trevor Mischki, Greg Lopinski, Jean Lapointe, Daniel Poitras, Siegfried Janz
  • Patent number: 8790934
    Abstract: Materials and methods for studying and modulating the interaction of carbohydrate-containing moieties with other species are described, in particular, small particles, e.g. clusters of metal or semiconductor atoms, which can be employed as a substrate for immobilising a plurality of ligands comprising carbohydrate groups. These “nanoparticles” can then be used to study carbohydrate mediated interactions, e.g. with other carbohydrates or proteins, and as therapeutics and diagnostic reagents.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: July 29, 2014
    Assignees: Consejo Superior de Investigaciones Cientificas, Midatech Limited
    Inventors: Soledad Penades, Javier Rojo, Manuel Martin-Lomas
  • Patent number: 8765484
    Abstract: The invention concerns a particle having a code embedded in its physical structure by refractive index changes between different regions of the particle. In preferred embodiments, a thin film possesses porosity that varies in a manner to produce a code detectable in the reflectivity spectrum.
    Type: Grant
    Filed: January 31, 2003
    Date of Patent: July 1, 2014
    Assignee: The Regents of the University of California
    Inventors: Michael J. Sailor, Thomas Schmedake, Frederique Cunin, Jamie Link
  • Patent number: 8753872
    Abstract: A method and apparatus for assay of multiple analytes. The method uses a sensing element comprising a substrate upon which is arranged a multiplicity of recognition elements, such that each element is laid out in a predetermined pattern. Each pattern is unique in that it can give rise to a characteristic diffraction pattern in the assay. The patterns may or may not be interpenetrating on the substrate surface. The method of detecting multiple analytes includes contacting the medium of analytes with the patterned substrate, illuminating the substrate by a light source, and detecting any resultant diffraction image. The pattern of diffraction and the intensity of the diffracted signal provides information about the existence of specific analytes and their quantification.
    Type: Grant
    Filed: December 20, 2005
    Date of Patent: June 17, 2014
    Assignee: Axela Inc.
    Inventors: M. Cynthia Goh, Jane B. Goh, Richard Mcaloney, Richard Loo
  • Patent number: 8735176
    Abstract: The present invention relates to a metal oxide nano-composite magnetic material, fabrication method, and method for linkage, enrichment, and isolation of phosphorylated species. The metal oxide nano-composite magnetic material comprises the magnetic iron oxide nanoparticle, a silica layer immobilized onto the magnetic iron oxide nanoparticle and a metal oxide layer coated onto the silica layer. The magnetic iron oxide nanoparticles can be used for absorbing microwave radiation to accelerate the enrichment and linkage for phosphorylated species onto the metal oxide nano-composite magnetic material. Furthermore, the magnetic property of magnetic iron oxide nanoparticles leads to isolation of the metal oxide nano-composite magnetic material-target species conjugates by simply employing an external magnetic field.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: May 27, 2014
    Assignee: National Chiao Tung University
    Inventors: Yu-Chie Chen, Cheng-Tai Chen, Wei-Yu Chen, Chun-Yuen Lo, Hong-Yi Lin, Chih-Chi Liu
  • Patent number: 8735174
    Abstract: Coated colloidal materials, methods for making coated colloidal materials, and methods of using coated colloidal materials are disclosed. The method yields coated colloidal materials where the optical characteristics of the core is not adversely affected. The coated colloidal materials can be self-assembled into films, layers, or structures and used in the detection of analytes through detection assays.
    Type: Grant
    Filed: July 23, 2008
    Date of Patent: May 27, 2014
    Assignee: Northwestern University
    Inventors: Chad A. Mirkin, Xiaodong Chen, Can Xue, Sarah J. Hurst
  • Patent number: 8722427
    Abstract: A method for determining the dissociation constant (Kd) by plotting resonance frequency shift as a function of time for various target analyte concentrations. From this graph, the fraction of saturation, i.e. equilibrium fraction of bound binding sites out of all available binding sites on the sensor surface may be estimated by taking the ratio of the equilibrium resonance frequency shift at a selected concentration to the equilibrium frequency shift of the sensor. The dissociation constant is the inverse slope of the line produced by graphing the fraction of saturation as a function of concentration. This method is particularly useful for the study of protein-protein and protein-mRNA interactions.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: May 13, 2014
    Assignee: Drexel University
    Inventors: Wan Y. Shih, Joseph Capobianco, Wei-Heng Shih
  • Patent number: 8703505
    Abstract: A biosensor having an optical fiber having at least one curved portion configured to enhance penetration of evanescent waves; and one or more nanoparticles associated with the optical fiber, and configured to enhance localized surface plasmon resonance.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: April 22, 2014
    Assignee: Indian Institute of Technology Bombay
    Inventors: Vemulakonda Venkata Raghavendra Sai, Soumyo Mukherji, Tapanendu Kundu
  • Patent number: 8685755
    Abstract: A new fractionation device shows desirable features for exploratory screening and biomarker discovery. The constituent MSCs may be tailored for desired pore sizes and surface properties and for the sequestration and enrichment of extremely low abundant protein and peptides in desired ranges of the mass/charge spectrum. The MSCs are effective in yielding reproducible extracts from complex biological samples as small as 10 ?l in a time as short as 30 minutes. They are inexpensive to manufacture, and allow for scaled up production to attain the simultaneous processing of a large number of samples. The MSCs are multiplexed, label-free diagnostic tools with the potential of biological recognition moiety modification for enhanced specificity. The MSCs may store, protect and stabilize biological fluids, enabling the simplified and cost-effective collection and transportation of clinical samples.
    Type: Grant
    Filed: July 20, 2010
    Date of Patent: April 1, 2014
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Mauro Ferrari, Xuewu Liu, Ennio Tasciotti, Ali Bouamrani, Ye Hu
  • Publication number: 20140080139
    Abstract: One aspect of the invention provides a nanoscale wire that has improved sensitivity, for example, as the carrier concentration in the wire is controlled by an external gate voltage. In one set of embodiments, the nanoscale wire has a Debye screening length that is greater than the average cross-sectional dimension of the nanoscale wire when the nanoscale wire is exposed to a solution suspected of containing an analyte. In certain instances, the Debye screening length associated with the carriers inside nanoscale wire may be adjusted by adjusting the voltage, for example, a gate voltage applied to an FET structure. In some cases, the nanoscale wire can be operated under conditions where the carriers in the nanoscale wire are depleted and the nanoscale wire has a conductance that is not linearly proportional to the voltage applied to the nanoscale wire sensor device, for example, via a gate electrode.
    Type: Application
    Filed: September 18, 2013
    Publication date: March 20, 2014
    Applicant: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Xuan Gao, Gengfeng Zheng
  • Patent number: 8674163
    Abstract: A DNA hybrid which comprises a porous oxide matrix and DNA immobilized thereon, and is useful for environmental clean-up, where the hybrid is prepared by removing a dispersion medium from a dispersion of colloidal oxide and DNA.
    Type: Grant
    Filed: January 16, 2007
    Date of Patent: March 18, 2014
    Assignee: Canon Kabushiki Kaisha
    Inventors: Zuyi Zhang, Teigo Sakakibara, Yoshinori Kotani, Norio Nishi
  • Patent number: 8658432
    Abstract: An objective is to provide Si/Si3N4 system nanosized particles each exhibiting reduced environmental load together with minimized bio toxicity, excellent chemical stability, enhanced relative light emission intensity, and less degradation of emission intensity during continuous exposure to light; a biosubstance labeling agent capable of keeping on labeling a biosubstance exhibiting luminance enhanced for a long duration with the Si/Si3N4 system nanosized semiconductor particle of the present invention; and also a method of manufacturing the Si/Si3N4 system nanosized semiconductor particle of the present invention.
    Type: Grant
    Filed: January 23, 2007
    Date of Patent: February 25, 2014
    Assignee: Konica Minolta Medical & Graphic, Inc.
    Inventors: Naoko Furusawa, Yasushi Nakano, Kazuya Tsukada
  • Patent number: 8580578
    Abstract: Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: November 12, 2013
    Assignee: X-Body, Inc.
    Inventors: Brian T. Cunningham, Jane Pepper, Bo Lin, Peter Li, Homer Pien, Jean Qiu
  • Patent number: 8563328
    Abstract: A method for biosensing that includes passing, via convective flow, a sample believed to contain one or more target biomarkers through a microfluidic channel and over the surface of an optical waveguide that has been prepared to bind the one or more target biomarkers, and sensing for an emission output from the optical waveguide at a wavelength that is characteristic of the binding of the target biomarker. A biosensor device that includes a module defining at least one microfluidic channel, an optical waveguide exposed along at least a portion of its length to fluid flow within the microfluidic channel, where a surface of the optical waveguide being prepared to bind a target biomarker, and an excitation source to couple an excitation wavelength of light into the optical waveguide. The device also includes a sensor for detecting emission light from the optical waveguide at an emission wavelength characteristic of binding of the target biomarker.
    Type: Grant
    Filed: February 16, 2006
    Date of Patent: October 22, 2013
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Kyung Aih Kang, Chong H. Ahn
  • Patent number: 8557590
    Abstract: A method for measuring glycated hemoglobin includes hemolyzing a blood sample with a hemolysate; reacting the hemolyzed blood sample with bead conjugates in which beads are conjugated with glycated hemoglobin binding materials; measuring the amount of total hemoglobin in the reacted blood sample; isolating normal hemoglobin from the glycated hemoglobin conjugated with the bead conjugates; measuring the amount of glycated hemoglobin isolated from the normal hemoglobin; and determining the percentage of the glycated hemoglobin in the blood sample on the basis of the measured amounts of total hemoglobin and glycated hemoglobin. The isolation of normal hemoglobin is performed by absorbing the normal hemoglobin using an absorption pad that is a porous pad having pores, each of which has a size greater than the size of the normal hemoglobin and smaller than the size of the bead.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: October 15, 2013
    Assignee: Infopia Co., Ltd.
    Inventors: Byeong-Woo Bae, Sung-Dong Lee, Hyong-Soo Kim
  • Patent number: 8551759
    Abstract: An oligomer probe array having improved reaction yield is provided. The oligomer probe array includes a substrate, an immobilization layer on the substrate, a plurality of nano particles coupled with a surface of the immobilization layer, and a plurality of oligomer probes coupled with surfaces of the nano particles.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: October 8, 2013
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Jung-hwan Hah, Sung-min Chi, Kyoung-seon Kim, Won-sun Kim, Han-ku Cho, Sang-jun Choi, Man-hyoung Ryoo
  • Patent number: 8551716
    Abstract: The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.
    Type: Grant
    Filed: June 19, 2012
    Date of Patent: October 8, 2013
    Assignee: X-Body, Inc.
    Inventors: Christine C. Genick, Lance G. Laing, Peter Li, Timothy F. Smith, Lara Madison, Bo Lin
  • Patent number: 8546130
    Abstract: An oligomer probe array with improved signal-to-noise ratio includes a substrate, a plurality of probe cell active regions formed on or in the substrate, with each of the plurality of probe cell active regions having a substantially planar surface and being coupled with at least one oligomer probe with own sequence, and a probe cell isolation region defining the probe cell active regions and having no functional groups for coupling with the oligomer probes on a surface.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: October 1, 2013
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Jung-hwan Hah, Sung-min Chi, Kyoung-seon Kim, Won-sun Kim
  • Patent number: 8535951
    Abstract: The present disclosure provides a reagent for detection of analyte in a sample and process of preparation of the reagent. The reagent comprises heparin and substrate coated with the analyte-counterpart. The analyte-counterpart of the reagent is capable of binding to said analyte. The present disclosure further provides a process for detection of an analyte in a sample by contacting said sample with said reagent and detecting formation of analyte-analyte counterpart complex. The present disclosure provides a kit for detection of an analyte in a sample.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: September 17, 2013
    Assignees: Director General, Defense Research & Development Organisation, Indian Institute of Science
    Inventors: Ganga Prasad Rai, Gauri Shanker Agarwal, Samuel Merwyn Packia Raj, Krishnamurthy Sekhar, Ajay Kumar Sood, Ajay Singh Negi
  • Patent number: 8513031
    Abstract: Disclosed are fluorescent substance-containing silica nanoparticles containing a fluorescent substance therein featured in that the surface of the silica nanoparticles is coated with a material having a bulk refractive index of from 1.60 to 4.00. The invention can provide fluorescent substance-containing silica nanoparticles excellent in long term storage stability and a biosubstance labeling agent employing the same.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: August 20, 2013
    Assignee: Konica Minolta Medical & Graphic, Inc.
    Inventors: Takuji Aimiya, Hideki Hoshino
  • Patent number: 8507212
    Abstract: A process for treating biological targets in a fluid of a biological organism, including introducing a fluid comprising a biological target to an assembly comprising an inlet connected to receive the fluid and an outlet connected to pass the fluid from the assembly, wherein the assembly comprises a flow chamber for conveying a flow of the fluid, and a capture zone comprising a target-specific binding agent, wherein during flow of the fluid through the flow chamber, the biological target undergoes flux rolling along the target-specific binding agent.
    Type: Grant
    Filed: January 10, 2012
    Date of Patent: August 13, 2013
    Assignee: Biomed Solutions LLC
    Inventors: Patrick R. Connelly, Jeffrey L. Helfer, Andrew W. Custer, Michael B. Kim
  • Patent number: 8497131
    Abstract: Surface Enhanced Spectroscopy-Active Composite Nanoparticles (SACN) comprising: core/shell nanoparticles comprising nanoparticle cores covered with shells, wherein the cores and the shells may comprise the same or different materials; at least one Raman-active reporter molecule associated with said core/shell nanoparticle; and an SiO2 encapsulant which encapsulates the core/shell nanoparticle and the at least one Raman-active reporter molecule, are described.
    Type: Grant
    Filed: April 25, 2005
    Date of Patent: July 30, 2013
    Assignee: Becton, Dickinson and Company
    Inventors: Michael J. Natan, Sharron Gaynor Penn, R. Griffith Freeman, Gabriela Chakarova, William E. Doering, Ian D. Walton
  • Patent number: 8492139
    Abstract: This invention relates to a detection system for measuring a fluorescent signal in a fluorescent assay. The system comprises a probe having a small sensing surface bound with a fluorescent label, and a light source and a detector both mounted at the proximal side of the sensing surface of the substrate. The invention also relates to a method for detecting an analyte in a liquid sample using a probe tip having a small surface area (?5 mm) and a high molecular weight polymer (?1 MD) having multiple binding molecules and multiple fluorescent labels. The binding reaction is accelerated by flowing the reaction solutions laterally and moving the probe tip up and down in the reaction vessels. The invention furthers relates to a fluorescent labeling composition comprising a cross-linked FICOLL® molecule having a plurality of binding molecules and a plurality of fluorescent labels.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: July 23, 2013
    Assignee: Access Medical Systems, Ltd.
    Inventors: Hong Tan, Robert F. Zuk, Yushan Tan, Erhua Cao, Min Xia, Jun Chen
  • Patent number: 8486619
    Abstract: A sensor chip for detecting an immune response against an influenza virus, the sensor chip including a substrate having a surface and a plurality of hemagglutinin polypeptides bound to discrete locations on the surface of the substrate, each hemagglutinin polypeptide having a hemagglutinin epitope. Detection devices containing the sensor chip and methods of detecting influenza immune responses are also described herein.
    Type: Grant
    Filed: May 1, 2009
    Date of Patent: July 16, 2013
    Assignee: University of Rochester
    Inventors: Benjamin L. Miller, Tim R. Mosmann, David Topham, Charles R. Mace
  • Patent number: 8481435
    Abstract: The present invention relates to a process for preparing a functionalized Si/Ge-surface, wherein an unfunctionalised Si/Ge-surface is contacted in the presence of ultraviolet radiation with a C2-C50 alkene and/or a C2-C50 alkyne, the alkene and/or alkyne being optionally substituted and/or being optionally interrupted by one or more heteroatoms. The present invention further relates to articles or substrates comprising the functionalized Si/Ge-surface and the use of the functionalised Si/Ge-surface to prevent or to reduce adsorption of a biomolecule to an article or a substrate.
    Type: Grant
    Filed: July 31, 2008
    Date of Patent: July 9, 2013
    Assignee: Wageningen University
    Inventors: Catharina Gerarda Petronella Henrica Schroën, Michel Rosso, Johannes Teunis Zuilhof
  • Patent number: 8481335
    Abstract: The invention is directed to a sensor system including at least one sensor and target specific receptors bound substrates for purposes of enhancing detection sensitivity. Optionally, the sensor system may include quantum dots for independently verifying the presence of a target molecule or compound. The sensor system may be particularly beneficial in the field of medical diagnostics, bio-defense, food safety, water safety and general chemical detection.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: July 9, 2013
    Assignee: Drexel University
    Inventors: Wei-Heng Shih, Wan Y. Shih
  • Patent number: 8476007
    Abstract: A biosensor having an optical fiber having at least one curved portion configured to enhance penetration of evanescent waves; and one or more nanoparticles associated with the optical fiber, and configured to enhance localized surface plasmon resonance.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: July 2, 2013
    Assignee: Indian Institute of Technology Bombay
    Inventors: Vemulakonda Venkata Raghavendra Sai, Soumyo Mukherji, Tapanendu Kundu
  • Patent number: 8455255
    Abstract: The present invention presents a silica particle containing at least one silica compound selected from a group consisting of mercapto-propyl-trimethoxysilane (MPS), mercapto-propyl-triethoxysilane (MPES), mercapto-propyl-methyldimethoxysilane (MPDMS), trimethoxy[2-(7-oxabicyclo[4.1.0]-hepto-3-yl)ethyl]silane (EpoPS), thiocyanatopropyltriethoxysilane (TCPS), and acryloxypropyltrimethoxysilane (AcPS), which can be provided and utilized as a label, a marker, or the like for qualitative test and quantitative test for such as prophylactic agent, therapeutic agent, diagnostic agent, diagnostic and therapeutic agent or the like in dental, medical and veterinary fields regardless of fields.
    Type: Grant
    Filed: June 7, 2007
    Date of Patent: June 4, 2013
    Assignee: The University of Tokushima
    Inventor: Michihiro Nakamura
  • Patent number: 8454895
    Abstract: This invention refers to continuous flow devices for detecting and/or removal of contaminants from a liquid stream. The device comprises a cartridge with an inlet and outlet for the liquid stream, a radiation incident and emerging wall portion and optically transparent support material packed in the cartridge such that a liquid stream can pass between voids or spaces formed within the optically transparent material, as well as a radiation source and detector. The support material comprises molecules for capturing at least one contaminant on the surface of the support material and each of the capture molecules comprises at least one reporter group which emits a signal upon binding of the contaminant. Another form of the invention refers to a rotatable support within the liquid stream.
    Type: Grant
    Filed: May 2, 2008
    Date of Patent: June 4, 2013
    Assignee: Nanyang Technological University
    Inventors: Karina Yew-Hoong Gin, Trevor R. Garrett
  • Patent number: 8455265
    Abstract: A surface grafted conjugated polyelectrolyte (CPE) is formed by coupling a CPE by a coupling moiety to the surface of a substrate. The substrate can be of any shape and size, and for many uses of the surface grafted CPE, it is advantageous that the substrate is a nanoparticle or microparticle. Surface grafted CPEs are presented that use silica particles as the substrate, where a modified silane coupling agent connects the surface to the CPE by a series of covalent bonds. Two methods of preparing the surface grafted CPEs are presented. One method involves the inclusion of the surface being modified by the coupling agent and condensed with monomers that form the CPE in a grafted state to the substrate. A second method involves the formation of a CPE with terminal groups that are complimentary to functionality that has been placed on the surface of the substrate by reaction with a coupling agent. The surface grafted CPEs are also described for use as biosensors and biocides.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: June 4, 2013
    Assignee: STC.UNM
    Inventors: David G. Whitten, Sireesha Chemburu, Thomas Corbitt, Linnea Ista, Gabriel Lopez, Kirk S. Schanze, Motokatsu Ogawa, Eunkyung Ji
  • Patent number: 8450056
    Abstract: A sensor chip for detecting an immune response against a virus, the sensor chip including a substrate having a surface and a plurality of virus-like particles or capsid fragments bound to discrete locations on the surface of the substrate. Detection devices containing the sensor chip and methods of detecting anti-viral immune responses are also described herein.
    Type: Grant
    Filed: May 1, 2009
    Date of Patent: May 28, 2013
    Assignee: University of Rochester
    Inventors: Benjamin L. Miller, Tim R. Mosmann, Robert C. Rose, Charles R. Mace
  • Patent number: 8440468
    Abstract: Provided is a method for amplifying a frequency variation of a detected signal in a biosensor that is used for detecting a biomolecule by measuring a change in frequency of an oscillating signal, the change being caused by pressure a biomolecule applies to a piezoelectric substance. The method for amplifying a frequency variation of a detected signal comprises the steps of: (a) applying a sample to a probe being fixed to an upper portion of a substrate of the biosensor to allow a biomolecule in the sample to be bound to the probe; (b) applying protein tagged with a metal particle to the biosensor to allow the protein and the biomolecule to be bound with each other; and (c) applying a metal enhancer to the biosensor to allow the metal enhancer to be bound to the metal particle having been bound to the protein.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: May 14, 2013
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Hun Joo Lee, Soo Suk Lee
  • Patent number: 8426152
    Abstract: The present invention provides a method of detecting changes in the refractive index at the surface of a localized surface plasmon resonance (LSPR) detection system. The method includes generating an insoluble product from an enzymatic substrate using an immobilized enzyme, wherein the insoluble product accumulates at a LSPR supporting surface. The method also includes detecting changes in the reflected or transmitted light of the surface arising from the presence of the insoluble product using LSPR.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: April 23, 2013
    Assignee: LamdaGen Corporation
    Inventors: Daniele Gerion, Randy Storer, Hiroyuki Takei
  • Patent number: 8404456
    Abstract: The present invention provides compositions and methods for treating or preventing antibody mediated graft rejection and blood typing.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: March 26, 2013
    Assignee: AbSorber AB
    Inventors: Jan Holgersson, Jining Liu, Linda Lindberg, Per Grufman
  • Patent number: 8399055
    Abstract: The invention provides, inter alia, capillary extraction devices, and methods of making and using the same.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: March 19, 2013
    Inventors: Rania Bakry, Gunther Bonn, Douglas T. Gjerde, Christian W. Huck, Gunther Stecher