Glass Or Silica Patents (Class 436/527)
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Patent number: 7385022Abstract: Disclosed is a polythiocarbonate polythiol including repeating units represented by the chemical formula (I): in which formula (I), R represents a divalent hydrocarbon group, which hydrocarbon group may have at least one substituent which does not take part in a reaction with the polyisocyante component and the carbon chain in the hydrocarbon group may include at least one member selected from hetero atoms and an —OCO— group, and the polythiocarbonate polythiol has a number average molecular weight of 200 to 2500.Type: GrantFiled: January 4, 2007Date of Patent: June 10, 2008Assignee: Ube Industries, Ltd.Inventors: Masanori Watanabe, Masahiko Watanabe, Atsushi Morikami, Takafumi Hirakawa
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Patent number: 7368281Abstract: An evanescent-field sensor system and method of using the system to detect either liquid- or airborne biological pathogens, chemical agents, and other harmful or toxic species is provided. The sensor system involves 1) an evanescent-field sensor having a substrate surface with at least a partial bio- or chemo-responsive layer, which forms a part of a serially renewable sensing region; 2) an optical interrogation apparatus for monitoring the bio- or chemo-responsive layer; and 3) an air-fluid delivery system. The optical interrogation apparatus has a light source, an optical delivery system, and a detection instrument or device. The air-fluid delivery system includes either macro or micro-fluidic passages designed to convey biological or chemical analytes to a sensing region.Type: GrantFiled: March 5, 2004Date of Patent: May 6, 2008Assignee: Corning IncorporatedInventors: Eric J. Mozdy, Frederic J-Y Quan, Po Ki Yuen
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Patent number: 7364919Abstract: Materials and methods for studying and modulating the interaction of carbohydrate-containing moieties with other species are described, in particular, small particles, e.g. clusters of metal or semiconductor atoms, which can be employed as a substrate for immobilizing a plurality of ligands comprising carbohydrate groups. These “nanoparticles” can then be used to study carbohydrate mediated interactions, e.g. with other carbohydrates or proteins, and as therapeutics and diagnostic reagents.Type: GrantFiled: October 16, 2001Date of Patent: April 29, 2008Assignee: Midatech LimitedInventors: Soledad Penades, Javier Rojo, Manuel Martin-Lomas
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Patent number: 7351838Abstract: Compounds having two reactive functional groups are described that can be used as a tethering compound to immobilize an amine-containing material to a substrate. The first reactive functional group can be used to provide attachment to a surface of a substrate. The second reactive functional group is a N-sulfonyldicarboximide group that can be reacted with an amine-containing material, particularly a primary aliphatic amine, to form a connector group between the substrate and the amine-containing material. The invention also provides articles and methods for immobilizing amine-containing materials to a substrate.Type: GrantFiled: March 14, 2007Date of Patent: April 1, 2008Assignee: 3M Innovative Properties CompanyInventors: Karl E. Benson, Moses M. David, Cary A. Kipke, Brinda B. Lakshmi, Charles M. Leir, George G. Moore, Rahul Shah
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Patent number: 7348147Abstract: The present invention relates to a method of detecting nucleic acids comprising suspending at least one recognizable target nucleic acid in a suspending solution containing polymeric particles marked with a probe, wherein the probe has an affinity for the target nucleic acid, adding a recognition unit-peroxidase conjugate marker to the suspending solution, forming a complex of the polymeric particles marked with a probe, the target nucleic acid and the recognition unit-peroxidase conjugate marker, contacting the suspending solution with a gelatin surface, adding a developer to the suspending solution in contact with the gelatin surface in the presence of phenol to attach the complex to the gelatin surface, washing the gelatin surface, and detecting the complex attached to the gelatin surface.Type: GrantFiled: November 15, 2004Date of Patent: March 25, 2008Assignee: Carestream Health, Inc.Inventors: Tiecheng A. Qiao, Brian J. Kelley
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Patent number: 7341692Abstract: Apparatus comprising a surface site layer having a distal site end, wherein the distal site end includes a substantially inorganic surface having a chemical composition selected from a group consisting of metals, semiconductors, insulators, and mixtures thereof, the surface positioned within a polypeptide bonding region and having a selective bonding affinity for a polypeptide; a plurality of interlayers between which the surface site layer is interposed, wherein the distal site end is distanced from the interlayers, first and second supports, wherein the surface site layer and the interlayers are interposed between the first and second supports; and first and second conductors provided on the first and second supports and having respective first and second distal conductor ends positioned within the polypeptide bonding region; wherein the conductors are capable of applying an external voltage potential across the polypeptide bonding region.Type: GrantFiled: April 30, 2005Date of Patent: March 11, 2008Assignee: Lucent Technologies Inc.Inventors: Robert L. Willett, Kirk W. Baldwin, Loren N. Pfeiffer
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Patent number: 7332327Abstract: In a method for analysis biomolecules (3) attached to a solid surface of a substrate (1) are used for detecting the presence of analytes (4) in a sample by binding of the analytes to the biomolecules. The biomolecules (3) are attached directly to the surface of the substrate together with biomolecule-repellent molecules (5), which cover the surface between the biomolecules (3) to prevent nonspecific binding of analytes (4) and other biomolecules. The invention relates also to a biosensor where biomolecules (3) are attached directly to the substrate (1) together with biomolecule-repellent molecules (5), which cover the surface between the biomolecules (3) to prevent non-specific binding of analytes (4) and other biomolecules. The biomolecules (5) can be self-assembled hydrophilic polymers. One example of using the invention is immunological analysis using surface plasmon resonance (SPR).Type: GrantFiled: June 10, 2002Date of Patent: February 19, 2008Assignee: BioNavis Ltd.Inventors: Inger Vikholm, Janusz Sadowski
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Patent number: 7332351Abstract: Disclosed are silica-coated nanoparticles and a process for producing silica-coated nanoparticles. Silica-coated nanoparticles are prepared by precipitating nano-sized cores from reagents dissolved in the aqueous compartment of a water-in-oil microemulsion. A reactive silicate is added to coat the cores with silica. Also disclosed are methods for functionalizing silica-coated nanoparticles for use in a variety of applications.Type: GrantFiled: July 25, 2005Date of Patent: February 19, 2008Assignee: The University of FloridaInventors: Weihong Tan, Swadeshmukul Santra, Peng Zhang, Rovelyn Tapec, Jon Dobson
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Patent number: 7332344Abstract: A method of detecting an analyte is described in which an up-converting luminescent species that is excited by absorption of long wavelength light is provided as a donor of energy to an acceptor species that can be bound to, or generated in proximity to, the luminescent species. The analyte either alters the proximity between the luminescent species and the acceptor species or alters the absorbance or luminescence properties of the acceptor species. The luminescent energy donor is excited with long wavelength light and transfers up-converted energy to the proximate acceptor species and this transfer of energy is detected by measurement of appropriate luminescence properties of either the donor or of the acceptor or both.Type: GrantFiled: February 28, 2002Date of Patent: February 19, 2008Assignee: Photonic Research Systems LimitedInventor: Christopher G. Morgan
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Patent number: 7329388Abstract: An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a plurality of small-bore separation capillaries and includes a valve system. Analyte concentrators, having antibody-specific (or related affinity) chemistries, are stationed at the respective intersections of the transport capillary and separation capillaries to bind one or more analytes of interest. The apparatus allows the performance of two or more dimensions for the optimal separation of analytes. The apparatus may also include a plurality of valves surrounding each of the analyte concentrators to localize each of the concentrators to improve the binding of one or more analytes of interest.Type: GrantFiled: December 5, 2003Date of Patent: February 12, 2008Assignee: Princeton Biochemicals, Inc.Inventor: Norberto A. Guzman
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Patent number: 7329536Abstract: An apparatus comprising one or more piezoelectric mass sensors for use in diagnostic and analytic processes, in particular for immunochemical detection of diagnostically relevant analytes in real time, is described. Each piezoelectric mass sensor comprises a piezoelectric crystal with a receptor surface which has immobilized thereon a lawn of recombinant antibodies comprising single VH chain or single-chain Fv (scFv) polypeptides specific for a particular antigen. Binding of antigen to the recombinant antibodies results in a change in mass on the receptor surface which is detected as a change in resonant frequency. In a preferred embodiment, the receptor layer is a precious metal such as gold which facilitates self-assembly of the recombinant antibodies into a lawn on the receptor surface via a cysteine residue at the carboxy terminus of the attachment polypeptide.Type: GrantFiled: June 4, 2004Date of Patent: February 12, 2008Assignees: Oakland University, Vanderbilt UniversityInventors: Xiangqun Zeng, Gabrielle Stryker, Raymond L. Mernaugh
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Patent number: 7316932Abstract: The present invention is related to a method for separating a first population of cells from a second population of cells in a sample by discontinuous density gradient separation using dense particles to target the first population of cells and a density separation medium (DSM) that is at least about 0.001 g/cm3 higher than the density of the second population of cells.Type: GrantFiled: October 1, 2002Date of Patent: January 8, 2008Assignee: Stemcell Technologies Inc.Inventor: Steven M. Woodside
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Patent number: 7314764Abstract: A semiconductor nanocrystal compound is described capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation—when excited by an electromagnetic radiation source or a particle beam; and (2) an affinity molecule linked to the semiconductor nanocrystal. The semiconductor nanocrystal is linked to an affinity molecule to form a semiconductor nanocrystal probe capable of bonding with a detectable substance. Exposure of the semiconductor nanocrystal to excitation energy will excite the semiconductor nanocrystal causing the emission of electromagnetic radiation. Further described are processes for respectively: making the luminescent semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and using the probe to determine the presence of a detectable substance in a material.Type: GrantFiled: March 7, 2006Date of Patent: January 1, 2008Assignee: The Regents of the University of CaliforniaInventors: Shimon Weiss, Marcel Bruchez, Jr., Paul Alivisatos
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Patent number: 7314749Abstract: The present invention relates to a method and apparatus for detecting analytes in a medium, and more particularly the present invention relates to an assay based on light diffraction which appears or changes upon the binding of analytes to their specific receptors laid out in patterns on a substrate, which has high sensitivity due to the appropriate choice of such patterns. The present invention is based on the principle that the pattern of recognition elements, which gives rise to the diffraction of the incident light in a diffraction-based assay, can be chosen in such a way so as to facilitate detection, and to enhance the signal to be detected compared to known gratings such as parallel straight lines. In one aspect the substrate itself has a surface topography designed to enhance the diffraction pattern signals. In another aspect the substrate is a diffractive optic element having the analyte-specific receptors affixed to the optic element.Type: GrantFiled: September 13, 2002Date of Patent: January 1, 2008Assignee: Axela Biosensors Inc.Inventors: M. Cynthia Goh, Richard Loo, Jane B. Goh, Richard McAloney
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Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
Patent number: 7312090Abstract: Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices.Type: GrantFiled: August 22, 2006Date of Patent: December 25, 2007Assignee: SRU Biosystems, Inc.Inventors: Bo Lin, Jane Pepper, Brian T. Cunningham, John Gerstenmaier, Peter Li, Jean Qiu, Homer Pien -
Patent number: 7312073Abstract: Method for the detection and enumeration of viable microorganisms. A liquid that comprises one or more markers incorporated in a liquid sol-gel precursor, is provided. A transparent slide is coated with a thin uniform layer of the liquid sol-gel precursor composition. The microorganisms are separated from liquid sample to be analyzed by passing the sample through a filter, and then bringing the filter into close contact with the sol-gel coated slide. The filter is co-incubated with the sol-gel coated slide for a period of time and at a temperature suitable to promote uptake of the markers by the microorganisms. The gel-coated slide irradiated with an external energy source, so as to generate detectable signals emitted from the markers uptaken by the microorganisms. Image of the detectable signals emitted from the microorganisms are acquired, and analyzed using a computer system, in order to provide the identification and enumeration of the microorganisms.Type: GrantFiled: November 8, 2001Date of Patent: December 25, 2007Assignee: BioGem Optical Ltd.Inventors: Erich Shaw, Jean-Claude Robin
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Patent number: 7309614Abstract: The invention relates to compositions and methods for detecting biomolecular interactions. The detection can occur without the use of labels and can be done in a high-throughput manner. The invention further relates to self-referencing colorimetric resonant optical biosensors and optical devices.Type: GrantFiled: December 4, 2003Date of Patent: December 18, 2007Assignee: SRU Biosystems, Inc.Inventors: Cheryl Baird, Brian Cunningham, Peter Li
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Patent number: 7306941Abstract: A simple and convenient sensor and measuring apparatus utilizing the optical interference effect of an optical thin film capable of measuring the binding between biochemical substances at a high throughput and having alkali resistance. An optical thin film of silicon nitride is disposed on the first surface and the rear surface of a silicon substrate, and the thickness of the silicon nitride film is modified in a direction parallel to the film. A portion of the thin film with increased thickness is used as a sensor upon which a probe is disposed, and over which a sample-containing solution is caused to flow. The binding between the probe and biochemical sample is detected based upon the change of the intensity of reflected light.Type: GrantFiled: December 9, 2004Date of Patent: December 11, 2007Assignee: Hitachi, Ltd.Inventors: Toru Fujimura, Yasushi Goto
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Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
Patent number: 7300803Abstract: Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices.Type: GrantFiled: August 22, 2006Date of Patent: November 27, 2007Assignee: SRU Biosystems, Inc.Inventors: Bo Lin, Jane Pepper, Brian T. Cunningham, John Gerstenmaier, Peter Li, Jean Qiu, Homer Pien -
Patent number: 7300804Abstract: A method and apparatus for controlling the processing of a liquid sample, e.g., a blood sample, based on a measurement related to the sample's ability to coat a surface against which the sample is brought into contact while being routinely transported. Preferably, the sample is advanced through a tube, and the amount of sample residue remaining within the tube is measured and correlated to coating process subsequently carried out on the sample, e.g., a process for producing blood-smears on a microscope slide. In a preferred embodiment, the amount of sample residue in a blood-transport tube is used to control the motion profile (i.e., acceleration and velocity) of a drop-spreading member used to spread a blood drop on a microscope slide in an automated slide-making instrument.Type: GrantFiled: November 15, 2004Date of Patent: November 27, 2007Assignee: Beckman Coulter, Inc.Inventor: Jose Sellek-Prince
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Patent number: 7294502Abstract: The invention relates to a device for collecting samples of fluids, in particular of body fluids such as saliva, said device comprising an absorbent pad and two housing parts which are connected to the latter in a movable manner and can enclose the absorbent pad. The device permits easy and safe handling when taking a sample and when transferring the sample for testing for an analyte in the sample. The device can also be handled hygienically and safely by persons not trained in taking samples.Type: GrantFiled: May 28, 2002Date of Patent: November 13, 2007Assignee: EnviteC-Wismar GmbHInventors: Martin Eckermann, Martin Ullmann, Bernd Lindner
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Patent number: 7291496Abstract: An electronic sensor is provided for detecting the presence of one or more analytes of interest in a sample. The sensor preferably comprises a field effect transistor in which conductance is enhanced by analyte binding to receptors in the active region. An array of sensors may be formed to analyze a sample for multiple analytes.Type: GrantFiled: May 24, 2004Date of Patent: November 6, 2007Assignee: University of HawaiiInventor: James W. Holm-Kennedy
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Patent number: 7276368Abstract: The present invention provides an optical assay apparatus that includes a light source module and an optical sensor. The light source module produces light having a range of propagation angles. The sensor includes a light adjusting portion and an assay sensing portion. The light adjusting portion receives the light produced by the light source module and provides light having a propagation angle that is substantially constant to the assay sensing portion. In one embodiment, the sensor may be coupled with the light source module by an interrogation module which includes a window in which a waveguide is integrated. In another embodiment, the sensor and interrogation module are mounted in an automated assay platform that provides two-dimensional or three-dimensional movement of the sensor so that it can be sequentially immersed in solutions required to perform a particular assay protocol.Type: GrantFiled: February 1, 2002Date of Patent: October 2, 2007Assignee: Research International, Inc.Inventor: Elric W. Saaski
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Patent number: 7271008Abstract: The invention relates to a device and methods for determining the quality of reagents used in an assay process, particularly a multistep immunohistochemical assay. In particular, the device comprises a substrate with a plurality of compounds affixed to a substrate, where each compound is reactive with a reagent used in the assay.Type: GrantFiled: July 15, 2003Date of Patent: September 18, 2007Inventor: Alton David Floyd
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Patent number: 7264973Abstract: The instant invention provides compositions and methods for determining cell interactions that are faster than conventional methods and that require the use of fewer reagents than conventional methods.Type: GrantFiled: September 22, 2003Date of Patent: September 4, 2007Assignee: SRU Biosystems, Inc.Inventors: Bo Lin, Brian Cunningham, Peter Li
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Patent number: 7262063Abstract: The present invention relates to a systematic process for the creation of functionally organized, spatially patterned assemblies polymer-microparticle composites including the AC electric field-mediated assembly of patterned, self supporting organic (polymeric) films and organic (polymeric)—microparticle composite films of tailored composition and morphology; the present invention further relates to the incorporation of said assemblies into other structures. The present invention. also relates to the application of such functional assemblies in materials science and biology. Additional areas of application include sensors, catalysts, membranes, micro-reactors, smart materials. Miniaturized format for generation of multifunctional thin films.Type: GrantFiled: December 26, 2001Date of Patent: August 28, 2007Assignee: Bio Array Solutions, Ltd.Inventors: Sukanta Banerjee, Kairali Podual, Michael Seul
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Patent number: 7255835Abstract: Apparatus and method for acquiring an infrared spectrum of a sample having or suspected to have an amide I band, an amide II band, an amide III band, an amide A band, an OH stretching region or a combination thereof. A representative method includes providing a sample; providing an internal reflecting element (IRE) with a functionalized tip; contacting the sample with the IRE to form a sample-IRE interface; directing a beam of infrared (IR) radiation through the IRE under conditions such that the IR radiation interacts with the sample-IRE interface once; recording a reflectance profile over a range of preselected frequencies, whereby an infrared spectrum of the of a sample having or suspected of having an amide I band, an amide II band, an amide III band, an amide A band, an OH stretching region or a combination thereof, disposed in an aqueous solution is acquired.Type: GrantFiled: September 4, 2002Date of Patent: August 14, 2007Assignee: North Carolina State UniversityInventors: Stefan Franzen, Simon E. Lappi
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Patent number: 7247469Abstract: Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are described. Methods of both making and using the arrays of protein-capture agents are also disclosed. The invention arrays are particularly useful for various proteomics applications including assessing patterns of protein expression and modification in cells.Type: GrantFiled: May 24, 2005Date of Patent: July 24, 2007Assignee: Zyomyx, Inc.Inventors: Peter Wagner, Peter Kernen, Hongbo Lu, Huu Tran
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Patent number: 7244391Abstract: An apparatus for manipulating and testing molecules includes a surface to which the molecule is anchored at multiple points at one end, a paramagnetic bead on which said molecule is anchored at multiple points at its other end, and a magnetic means for applying a force to the bead, said magnetic means being used to control the stretching and rotation of said bead and said molecule. The apparatus also includes an optical magnification means and a camera for the visualization of said bead. The apparatus further includes a computer means to which images from the camera are transmitted. The computer means includes means for analyzing the motions of the bead. The apparatus also includes a rotating means for spinning the magnetic means about an optical axis of the magnification means.Type: GrantFiled: June 11, 2002Date of Patent: July 17, 2007Assignee: Centre National de la Recherche Scientifique (CNRS)Inventors: T. R. Strick, J. F. Allemand, D. Bensimon, A. Bensimon, V. Croquette
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Patent number: 7235361Abstract: The present invention provides a composition comprising fluorescent semiconductor nanocrystals associated to a compound, wherein the nanocrystals have a characteristic spectral emission, wherein said spectral emission is tunable to a desired wavelength by controlling the size of the nanocrystal, and wherein said emission provides information about a biological state or event.Type: GrantFiled: November 3, 2004Date of Patent: June 26, 2007Assignee: Massachusetts Institute of TechnologyInventors: Moungi G Bawendi, Vikram C Sundar, Frederic V Mikulec
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Patent number: 7232661Abstract: This invention is about a method for the prenatal diagnosis of preterm delivery, fetal infection, and fetal damage, and diagnostic reagent system and diagnostic kit for the diagnosis. The method, diagnostic reagent system, and kit are based on the finding that the level of MMP-8 in the amniotic fluid is significantly higher when the pregnant woman is at risk for preterm delivery, intrauterine infection, and fetal damage. The diagnostic reagent system and kit can be applied to patients with or without clinical signs of preterm labor or premature rupture of fetal membranes. With its superiority in sensitivity and specificity as well as its less invasiveness compared to the conventional method of measuring fetal blood cytokine levels, this diagnostic reagent system and kit is very useful in the prenatal diagnosis of preterm delivery, fetal infection, and fetal damage.Type: GrantFiled: August 1, 2001Date of Patent: June 19, 2007Assignee: Seoul National University Industry FoundationInventor: Bo Hyun Yoon
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Patent number: 7229835Abstract: A compound linked to a solid support (R) through a divalent linker moiety (X) and which is represented by the following formula: is disclosed. In particular, the 1-hydroxybenzotriazole-6-carboxylic acid is directly linked to the support under mild conditions (i.e., in aqueous or organic solvents at neutral pH and at room temperature). The polymer bound 1-hydroxybenzotriazole-6-carboxylic acid can be used for the derivatization of amines as well as for single step amino group modification of proteins, peptides, and amines via acylation or sulfonylation reactions. A flow through device and method for the single step amino group modifications of proteins, peptides, and amines is disclosed. Also disclosed is a flow through device for the detection of amines in a sample. Additionally, a device and method for the detection of amines in a sample using 1-hydroxybenzotriazole-6-carboxylic acid is disclosed. In a preferred embodiment, the device is used to detect the presence of amines in a spoiled meat product.Type: GrantFiled: October 25, 2001Date of Patent: June 12, 2007Assignee: The University of Maryland, Baltimore CountyInventor: Aristotle G. Kalivretenos
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Patent number: 7223534Abstract: A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the receptive material are defined in the receptive material layer by a masking process.Type: GrantFiled: May 3, 2002Date of Patent: May 29, 2007Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Rosann Kaylor, David Cohen, Curtis Sayre
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Patent number: 7217575Abstract: A covalent conjugate of a 4?-hydroxyazobenzene-2-carboxylic acid derivative (HABA) and an avidin-type molecule, of the formula: wherein A is (CH2)n or —CH?CH—, wherein n is an integer from 0–10; B is (CH2)n wherein n is an integer from 2 to 10; m is zero or 1; and Av is the residue of an avidin-type molecule selected from the group comprising native egg-white avidin, recombinant avidin, deglycosylated avidins, bacterial streptavidin, recombinant streptavidin, truncated streptavidin and other derivatives of said avidin-type molecules. These HABAylated avidins are red colored in the quinone configuration and can be used in many applications in the avidin-biotin technology.Type: GrantFiled: July 23, 2003Date of Patent: May 15, 2007Assignee: Yeda Research and Development Co. Ltd.Inventors: Meir Wilchek, Edward A Bayer, Heike Hofstetter, Margherita Morpurgo
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Patent number: 7211445Abstract: A method is provided for covalently linking carbohydrates, proteins, nucleic acids, and other biomolecules under neutral conditions, using a Diels-Alder cycloaddition reaction. In an example, activated carbon-carbon double bonds were attached to free amino sites of a carrier protein, and a conjugated diene was attached to a carbohydrate hapten. Spontaneous coupling of the carbohydrate and the protein components under very mild conditions provided glycoconjugates containing up to 37 carbohydrate hapten units per carrier protein molecule. The method is also applicable to the immobilization of biomolecules on gel or solid supports. The conjugated products are useful as immunogens and as analytical and diagnostic reagents.Type: GrantFiled: October 22, 2003Date of Patent: May 1, 2007Assignee: The United States of America as Represented by the Secretary of the Department of Health and Human ServicesInventor: Vince Pozsgay
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Patent number: 7211444Abstract: A fluidic waveguide comprising a container and a fluid that fills said container, wherein said fluid has a refractive index greater than the refractive index of the wall of said container and wherein said fluid can act as a waveguide for electromagnetic radiation when contacted therewith is disclosed. A corresponding fluidic lightguide along with devices that function as composite waveguides and lightguides are described. Assays utilizing this waveguide for biochemical, chemical, and other kinds of analyzes are also disclosed.Type: GrantFiled: April 26, 2002Date of Patent: May 1, 2007Assignee: Genetic ID NA, Inc.Inventor: John Fagan
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Patent number: 7208281Abstract: The invention relates to the use of specific ligand carriers for detecting prions, and to substances that are capable of binding to prions and that are subsequently used to detect prions.Type: GrantFiled: February 12, 2002Date of Patent: April 24, 2007Inventors: Holger Kiesewetter, Abdulgabar Salama
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Patent number: 7208286Abstract: Monolithic bioelectronic devices for the detection of ammonia includes a microorganism that metabolizes ammonia and which harbors a lux gene fused with a heterologous promoter gene stably incorporated into the chromosome of the microorganism and an Optical Application Specific Integrated Circuit (OASIC). The microorganism is generally a bacterium.Type: GrantFiled: June 14, 2005Date of Patent: April 24, 2007Assignee: UT-Battelle LLCInventors: Michael L. Simpson, Michael J. Paulus, Gary S. Sayler, Bruce M. Applegate, Steven A. Ripp
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Patent number: 7205161Abstract: Sensors for determining the presence and concentration of biomolecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface modified with a hydrophobic polymer segment, attached to which is a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, which allows for controlled architecture polymers to modify the surface of the substrate, and the use of monomers possessing functional groups which do not require activation prior to probe attachment. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.Type: GrantFiled: January 10, 2002Date of Patent: April 17, 2007Assignee: Symyx Technologies, Inc.Inventors: Gerrit Klaerner, Didier Benoit, Dominique Charmot, Srinivas Nomula, Marcelo Eduardo Piotti, Laura T. Mazzola
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Patent number: 7205116Abstract: Novel conjugates of 5-fluoro-uracil and novel 5-fluoro-uracil immunogens and monoclonal antibodies generated by these immunogens which are useful in immunoassays for the quantification and monitoring of 5-fluoro-uracil in biological fluids.Type: GrantFiled: February 2, 2006Date of Patent: April 17, 2007Inventors: Salvatore J. Salamone, Jodi Blake Courtney, Dennis Stocker
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Patent number: 7205155Abstract: This invention relates to a method for the determination of substances using the evanescence field method. A cuvette, a microtiter well, a solution and a kit for application in a method according to the invention are disclosed. This method can in particular be used in the field of diagnostics and in analytical procedures.Type: GrantFiled: August 18, 2000Date of Patent: April 17, 2007Assignees: Stiftung fur Diagnostische Forschung, Leuze Electronic GmbH & CoInventors: Manfred Schawaller, Gerald Quapil
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Patent number: 7202076Abstract: Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters.Type: GrantFiled: October 23, 2001Date of Patent: April 10, 2007Assignee: SRU Biosystems, Inc.Inventors: Brian Cunningham, Jane Pepper, Bo Lin, Peter Li, Homer Pien
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Patent number: 7198957Abstract: A method for analyzing a substance, comprising: a step of obtaining a dispersion complex by co-existing fine particles having a dispersion property higher than that of lyophobic fine particles in a dispersion phase of the lyophobic fine particles at a concentration sufficient for covering a periphery of a lyophobic fine particle group; a step of contacting the dispersion complex and a fluid containing an analyte; and a step of analyzing the analyte using an optical measuring means, wherein the lyophobic fine particles exist in the dispersion phase in a group for providing the surface enhancing effect. The method is effective for analysis of a slight amount substance or a low concentration substance.Type: GrantFiled: March 9, 2001Date of Patent: April 3, 2007Inventors: Takao Fukuoka, Keitaro Nakamura, Yasushige Mori
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Patent number: 7195909Abstract: The subject invention pertains to a method for determining the affinity between binding partners, or a property of one of the binding partners dependent on the affinity, comprising the steps of: (i) contacting the binding partners, one of which is immobilised on a surface; (ii) oscillating the surface at increasing amplitude; and (iii) detecting a dissociation event. An analogous method can be used to separate a target analyte from a composition. The subject invention also pertains to an apparatus for determining the affinity between binding partners, and comprises: a surface (10) having one binding partner (16) immobilised thereon; means for oscillating the surface at increasing amplitude; and means (14, 15) for detecting a dissociation event.Type: GrantFiled: January 24, 2003Date of Patent: March 27, 2007Assignee: Akubio LimitedInventors: David Klenerman, Victor Petrovich Ostanin, Fedor Nikolaievich Dultsev
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Patent number: 7195924Abstract: Provided is a method for immobilizing a biomolecule on a solid substrate. The method includes coating the solid substrate with silane anhydride to introduce an anhydride functional group onto a surface of the solid substrate; obtaining a carboxyl group from the anhydride functional group by hydrolysis; reacting the carboxyl group with carbodiimide and succinimide to activate the carboxyl group; and contacting the biomolecule with the solid substrate having the activated carboxyl group on its surface to immobilize the biomolecule on the solid substrate.Type: GrantFiled: January 4, 2005Date of Patent: March 27, 2007Assignee: Samsung Electronics Co., Ltd.Inventor: Kyu-youn Hwang
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Patent number: 7195882Abstract: The present invention relates to monoclonal antibodies that specifically bind buprenorphine and/or at least one metabolic product thereof. The present invention further relates to buprenorphine metabolite conjugates for the production of monoclonal antibodies that specifically bind buprenorphine and/or at least one metabolic product thereof and hybridoma cells that produce the monoclonal antibodies. The invention also relates to immunoassay methods for determining buprenorphine and/or one or more buprenorphine metabolites in a sample using the novel antibodies and conjugates of the present invention.Type: GrantFiled: June 3, 2003Date of Patent: March 27, 2007Assignee: Roche Diagnostics Operations, Inc.Inventors: Richard T. Root, Mitali Ghoshal
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Patent number: 7192778Abstract: Metal nanoparticles associated with a spectroscopy-active (e.g., Raman-active) analyte and surrounded by an encapsulant are useful as sensitive optical tags detectable by surface-enhanced spectroscopy (e.g., surface-enhanced Raman spectroscopy).Type: GrantFiled: January 16, 2003Date of Patent: March 20, 2007Inventor: Michael J. Natan
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Patent number: RE39545Abstract: The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is labeled with a unique identifier tag that specifies the structure or sequence of the oligomer. In a preferred embodiment of the present invention the identifier tag is a microchip that is pre-encoded or encodable with information that is related back to a detector when the identifier tag is pulsed with electromagnetic radiation.Type: GrantFiled: May 7, 2004Date of Patent: April 3, 2007Assignee: Nexus Biosystems, Inc.Inventor: John Cargill
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Patent number: RE39571Abstract: The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is labeled with a unique identifier tag that specifies the structure or sequence of the oligomer. In a preferred embodiment of the present invention the identifier tag is a microchip that is pre-encoded or encodable with information that is related back to a detector when the identifier tag is pulsed with electromagnetic radiation.Type: GrantFiled: May 7, 2004Date of Patent: April 17, 2007Assignee: Nexus Biosystems, Inc.Inventor: John Cargill
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Patent number: RE39606Abstract: The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is labeled with a unique identifier tag that specifies the structure or sequence of the oligomer. In a preferred embodiment of the present invention the identifier tag is a microchip that is pre-encoded or encodable with information that is related back to a detector when the identifier tag is pulsed with electromagnetic radiation.Type: GrantFiled: May 7, 2004Date of Patent: May 1, 2007Assignee: Nexus Biosystems, Inc.Inventor: John Cargill