Abstract: A semiconductor die includes a chemical sensor, a digital to analog converter, and microcontroller formed therein. The chemical sensor detects the presence of a chemical and outputs an analog signal to the digital to analog converter. The analog to digital converter converts the analog signal to a digital signal. The analog to digital converter outputs the digital signal to the microcontroller. Microcontroller calculates a value of the concentration of the selected chemical.

Abstract: The invention relates to an apparatus and to a method for detecting and/or quantifying mercuric ions, Hg2+. The apparatus of the invention is of the type comprising an electrical device comprising two electrodes and a substrate comprising at least one surface made of an organic or inorganic semiconductor material, the electrodes being in electrical contact with said organic or inorganic semiconductor material, and a device for measuring the variation in the conduction current between the two electrodes, and wherein at least one compound which complexes mercuric ions Hg2+, selected from a dithia-dioxa-monoaza crown ether compound, an N,N-di(hydroxyethyl)amine, an N,N-di(carboxyethyl)amine, and mixtures of two at least of these compounds, is bonded to said semiconductor material or to an electrode of said electrical device. The invention finds application in the field of the detection of mercuric ions, in particular.

Abstract: The present invention is a method to produce and to use a fluorogenic chemodosimeter for the detection of mercury ions in a sample at temperature ranges from about 0° C. to 100° C.

Abstract: A nucleic acid enzyme comprises an oligonucleotide containing thymine bases. The nucleic acid enzyme is dependent on both Hg2+ and a second ion as cofactors, to produce a product from a substrate. The substrate comprises a ribonucleotide, a deoxyribonucleotide, or both.

Abstract: A method for the equilibration of enriched isotope species and natural isotope species prior to mass spectrometric analysis using solid phase and/or microwave isotope ratio equilibration and measurement.

Abstract: Methods for rapid sensing of dissolved toxic heavy metals use a hybrid inorganic material (“HIM”), which is synthesized from hydrated iron oxide (“HFO”) and calcium magnesium silicate. HIM thus synthesized is used in sensing dissolved toxic heavy metals. Water containing toxic heavy metals (e.g., lead, copper, zinc, nickel, etc.) is passed through a sorbent bed of HIM, whereupon it shows a sharp drop in pH after a certain length of time. The presence of HFO and calcium magnesium silicates in HIM synergistically provide a precipitous drop in pH, which is characteristic of the concentration and type of toxic heavy metal. Therefore, observing a change in pH indicates the presence and identity of heavy metal ions in a test water sample.

Abstract: Calix[4]arenes of Formula I are useful for selectively detecting Zn2+ ion.

Abstract: Disclosed are a novel 8-hydroxyquinoline acetamide compound, an 8-hydroxyquinoline thioamide and use thereof. More specifically, disclosed are a novel 8-hydroxyquinoline thioamide compound suitable for use as a selective chemodosimeter that shows considerably high detection sensitivity to mercury ions, an 8-hydroxyquinoline acetamide compound as an intermediate thereof, preparation thereof, and a chemodosimeter for mercury ion-selective detection, the chemodosimeter comprising the 8-hydroxyquinoline thioamide compound. The compounds as disclosed herein exhibit considerably effective fluorescence specificity of an off-on type, detect a micromole of mercury ions from chemical and biological aqueous systems, and allow 100% desulfurization within 5 minutes, thus being considerably useful in the chemical industry.

Abstract: The present invention provides an electrochemical sensor having a solid electrically conductive substrate and a compound immobilized thereon which has binding affinity for an analyte species to be detected and also displays electrochemical behaviour which is modified upon binding of that analyte species, so that binding of an analyte species can be detected by measuring electrochemical properties, such as by voltammetry. Desirably the immobilised compound contains both a first moiety with binding affinity for the analyte and a separate second moiety which is a redox system whose electrochemical oxidation/reduction properties become modified when the first moiety binds the analyte. The analyte binding moiety may be a diol or polyol and preferably is a sugar. The electrochemical sensor finds use in methods of analysing reservoir and process fluids, particularly at a subterranean location. The electrochemical sensor may be a component of a downhole tool, adapted for deployment downhole.

Abstract: A highly sensitive fluid composition analyzer where a fluid may be placed in contact with a very small area on a material sensitized to change color in the presence of a specific type of compound, to be impinged with light. The light reflected, transmitted and/or scattered by the material may serve as input for the analyzer electronics. The fluid may be pre-concentrated prior to being brought in contact with the material. The area on the material may be a spot having an outside dimension of less than one millimeter.

Abstract: In particular, Compounds of Formula I or Formula II, generally known as calix[4]arenes, may be prepared. The compounds may be used to test samples for the presence of Hg2+ by fluorescence quenching. The compounds may also be used to selectively detect Hg2+ in samples containing other mono- or divalent metals.

Abstract: A mercury ionic gas standard generator for use in the continuous emissions monitoring of exhaust flue gas streams is disclosed. More specifically, the mercury ionic gas standard generator uses a reservoir being coated with an inert silicon-based coating for transporting a volume of an aqueous ionic mercury solution to a liquid mass flow controller and vaporizer.

Abstract: Methods and devices for detecting a concentration of one or more element in hydrocarbon and/or natural gas in a oil and gas field application. The device including a microstructure having a low thermal mass suspended within a channel, the microstructure includes a supporting layer and a insulating layer; a controllable thermal device in communication with the supporting layer of the microstructure, wherein the controllable thermal device is controllably heated to one or more release temperature of the one or more element; a sensing layer arranged on the insulating layer to absorb molecules of the one or more element from hydrocarbon and/or natural gas; a detecting and measuring resistance device in communication with the sensing layer for measuring the resistance changes caused by absorption of molecules of the one or more element onto the sensing layer at a first temperature and a second temperature, and storing the data on a processor.

Abstract: The present invention provides fluorogenic compounds for the detection of target metal ions wherein the compounds exhibit a Stokes shift greater than 50 nm and the detectable signal is modulated by photoinduced electron transfer (PET). The present compounds consist of three functional elements, the ion sensing moiety (chelating moiety), the reporter moiety (fluorophore or fluorescent protein) and spacer or linker between the sensing and reporter moieties of the present compound that allows for PET upon binding of a metal ion and excitation by an appropriate wavelength.

Abstract: An oxidized mercury converter utilizes a combination of heat, reduced pressure, and dilution when converting oxidized mercury in a gas sample into elemental mercury. The converter applies heat to a gas sample to thermally convert oxidized mercury within a gas sample into elemental mercury and an oxidizing component, and thereafter reduces the pressure of the gas sample to minimize combination of the elemental mercury with other oxidizing compounds present in the gas sample and/or with byproducts of the thermal conversion (e.g., the oxidizing components). The converter thus allows an accurate analysis of the total amount of mercury, both oxidized and elemental forms, present within a gas sample without the need to use consumable reagents in the mercury conversion process.

Abstract: The present invention provides a sensor for detecting mercury, comprising: a first polynucleotide, comprising a first region, and a second region, a second polynucleotide, a third polynucleotide, a fluorophore, and a quencher, wherein the third polynucleotide is optionally linked to the second region; the fluorophore is linked to the first polynucleotide and the quencher is linked to the second polynucleotide, or the fluorophore is linked to the second polynucleotide and the quencher is linked to the first polynucleotide; the first region and the second region hybridize to the second polynucleotide; and the second region binds to the third polynucleotide in the presence of Hg2+ ions.

Abstract: A method for detecting and measuring a metal ion in an aqueous medium includes derivatizing a solid phase extraction material with a reactive material that undergoes a chemical reaction when contacted with the metal ion. The solid phase extraction material and the reactive material are positioned in an aqueous medium containing the metal ion, such that the metal ion contacts the reactive material and causes it to chemically react. The reaction of the reactive material is detected by optical spectroscopy to detect and measure the metal ion.

Abstract: Disclosed are a novel 8-hydroxyquinoline acetamide compound, an 8-hydroxyquinoline thioamide and use thereof. More specifically, disclosed are a novel 8-hydroxyquinoline thioamide compound suitable for use as a selective chemodosimeter that shows considerably high detection sensitivity to mercury ions, an 8-hydroxyquinoline acetamide compound as an intermediate thereof, preparation thereof, and a chemodosimeter for mercury ion-selective detection, the chemodosimeter comprising the 8-hydroxyquinoline thioamide compound. The compounds as disclosed herein exhibit considerably effective fluorescence specificity of an off-on type, detect a micromole of mercury ions from chemical and biological aqueous systems, and allow 100% desulfurization within 5 minutes, thus being considerably useful in the chemical industry.

Abstract: A fluorescent sensor compound based on a perylene core is described and disclosed. The fluorescent sensor compound for detecting mercury can have a structure I: where A and A? are linking groups, B and B? are binding ligands which are selective for binding with Hg2+, and R1 through R8 are side groups. These fluorescence sensor materials are robust against photobleaching, while still providing exceptional detection sensitivity and selectivity.

Abstract: The present invention discloses a method and composition for testing the wear on mechanical hardware. During the testing method a metal oxidant is applied the mechanical hardware being tested which deposits onto the mechanical and can be visually detected. One of the properties of the metal oxidant is that it is a substantially non-flow or non-drip medium that can be applied in situ with reduced risk to surrounding hardware.

Abstract: This application relates to vaprochromic coordination polymers useful for analyte detection. The vapochromism may be observed by visible color changes, changes in luminescence, and/or spectroscopic changes in the infrared (IR) signature. One or more of the above chromatic changes may be relied upon to identify a specific analyte, such as a volatile organic compound or a gas. The chromatic changes may be reversible to allow for successive analysis of different analytes using the same polymer. The polymer has the general formula MW[M?X(Z)Y]N wherein M and M? are the same or different metals capable of forming a coordinate complex with the Z moiety; Z is selected from the group consisting of halides, pseudohalides, thiolates, alkoxides and amides; W is between 1-6; X and Y are between 1-9; and N is between 1-5. Optionally, an organic ligand may be bound to M. In alternative embodiments of the invention M may be a transition metal, such as Cu and Zn.

Abstract: Provided herein are compounds, methods of making the compounds and methods for the sensitive and selective detection of Hg2+ with the compounds, which are calix[4]arenes. In particular, compounds of Formula I, wherein the variables have the values described herein, may be added to a sample to be tested for Hg2+. The compound of Formula (I) fluoresces strongly in the absence of Hg2+ but is quenched upon binding of Hg2+ to form a complex. The decrease in fluorescence may be used to detect and quantify the amount of Hg2+ present in a sample. The disclosed compounds may also be used to selectively detect Hg2+ in samples containing other mono- or divalent metals.

Abstract: The present technology provides a dual chemical sensor for zinc and nickel ions and a chemical sensor for copper ions. Also provided are methods of making and using the chemical sensors. The chemical sensors have the structure of formula I, wherein R1, and R2 are defined as set forth herein.

Abstract: The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.

Abstract: This application relates to vaprochromic coordination polymers useful for analyte detection. The vapochromism may be observed by visible color changes, changes in luminescence, and/or spectroscopic changes in the infrared (IR) signature. One or more of the above chromatic changes may be relied upon to identify a specific analyte, such as a volatile organic compound or a gas. The chromatic changes may be reversible to allow for successive analysis of different analytes using the same polymer. The polymer has the general formula MW[M?X(Z)Y]N wherein M and M? are the same or different metals capable of forming a coordinate complex with the Z moiety; Z is selected from the group consisting of halides, pseudohalides, thiolates, alkoxides and amides; W is between 1-6; X and Y are between 1-9; and N is between 1-5. Optionally, an organic ligand may be bound to M.

Abstract: The present invention is a new class of fluorescent sensor with unprecedented sensitivity, selectivity and synthetic efficiency for the identification and qualitative and quantitative detection of transition metal ions. The chemosensing properties are based on an internal charge transfer mechanism or photo-induced electron transfer and are effective in vitro. The chemosensor comprises one or more electron donating dipyrrin functionalities linked to an electron withdrawing functionality. The chemosensor forms a stable transition metal complex through internal charge transfer between the electron donating functionality and the target transition metal, which results in measurable fluorescence. Specific examples for sensing zinc and copper ions are described.

Abstract: The invention relates generally to gold nanoclusters, and in particular, fluorescent gold nanoclusters. The gold nanoclusters may be stabilized, for example, with a protein or stabilizing agent. In some cases, the gold nanoclusters may be used in methods or articles to determine the presence, absence, and/or concentration of mercuric ions in a sample.

Abstract: The present invention provides a metal chelator and methods that facilitate binding, detecting, monitoring and quantitating of zinc ions in a sample. The metal chelating moiety of the zinc-binding compound is an analog of the well-known calcium chelator, BAPTA (1,2-bis(2-aminophenoxy)ethane-N,N,N?,N?-tetraacetic acid), wherein the chelating moiety has been modified from a tetraacetic acid moiety to a tri- di- or monoacetic moiety. This change in acetic acid groups on the metal chelating moiety results in the selective bindings of zinc ions in the presence of calcium ions, both of which are present in biological fluids and intracellular cytosolic fluid and organelles.

Abstract: A standard calibration set having at least three calibration standards. Each standard is a molded article made of a thermoplastic polymer which contains the elements Cd, Cr, Pb, Hg and Br, with the Cr:Pb:Hg:Br:Cd ratio being different in each of the three calibration standards. Further disclosed is a method for manufacturing the calibration standards and their use in X-ray fluorescence analysis.

Abstract: The present invention generally relates to Magnetic Resonance Imaging (MRI) analysis of the location, presence, and/or quantity of a particular molecule or material. In some embodiments, the invention relates to compositions and methods for determination of an analyte, wherein a compositions may produce an MRI signal that can be affected by the presence of a particular composition (e.g., analyte). In a particular embodiment, the composition comprises a protein. The invention also provides related nucleic acid molecules, polypeptides, and fragments thereof. Compositions of the invention may exhibit reduced toxicity and may be readily delivered in vivo. Various embodiments of the invention may be useful as sensors, diagnostic tools, and the like.

Abstract: Molecular bioprofiles comprising biologically correlated and relevant analytes that impact the biological state of a human health condition compared to a control population are provided. These molecular bioprofiles are useful in several ways including but not limited to, monitoring a disease or condition's progression, evaluating the impact of an agent or compound on a disease or condition, evaluating the impact of a lifestyle change on a disease or condition and assessing the risk of the disease or condition to a subject. Type II diabetes molecular bioprofiles are of particular interest.

Abstract: In particular, Compounds of Formula I or Formula II, generally known as calix[4]arenes, may be prepared. The compounds may be used to test samples for the presence of Hg2+ by fluorescence quenching. The compounds may also be used to selectively detect Hg2+ in samples containing other mono- or divalent metals.

Abstract: The invention relates to indicator molecules for detecting the presence or concentration of an analyte in a medium, such as a liquid, and to methods for achieving such detection. More particularly, the invention relates to copolymer macromolecules containing relatively hydrophobic indicator component monomers, and hydrophilic monomers, such that the macromolecule is capable of use in an aqueous environment.

Abstract: A fluorescent probe which specifically and efficiently traps nitrogen monoxide, zinc ion etc. to emit fluorescence is provided. A compound represented by the following general formula (I): [wherein R1 and R2 represent hydrogen atom, or a group represented by the following formula (A): (wherein X1 to X4 represent hydrogen atom, an alkyl group, or a protective group for amino group, and m and n represent 0 or 1); R3 and R4 represent hydrogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group; R5 to R12 represent hydrogen atom, sulfo group, phospho group, a halogen atom, or a C1-6 alkyl group; R13 and R14 represent a C1-18 alkyl group; Z1 represents oxygen atom, sulfur atom, or —N(R15)— (wherein R15 represents hydrogen atom, or a C1-6 alkyl group); Y1 and Y2 represent —C(?O)—, —C(?S)—, or —C(R16)(R17) (wherein R16 and R17 represent a C1-6 alkyl group); and M? represents a counter ion in a number required for neutralizing the charge].

Abstract: Terpyridine-substituted compounds, compositions and/or related methods, as can be used to selectively detect a wide range of analytes.

Abstract: The present invention provides methods of detecting prostate cancer employing biomarkers, including hZIP1, zinc and citrate. Also provided are antibodies to detect hZIP1 protein or peptides and an expression vector comprising a genetic sequence effective to increase uptake of zinc into a prostate cell upon expression thereof. Furthermore, methods of treating prostate cancer and of increasing uptake of zinc into a prostate cell are provided.

Abstract: The present technology provides a dual chemical sensor for zinc and nickel ions and a chemical sensor for copper ions. Also provided are methods of making and using the chemical sensors. The chemical sensors have the structure of formula I, wherein R1, and R2 are defined as set forth herein.

Abstract: An apparatus, process, coating, and filter for the accurate measurement of total mercury concentration in flue gas. In one aspect, the concentrations of both elemental and oxidized mercury are preserved by the apparatus for analysis. Accordingly, embodiments of the present apparatus and process can be used to determine regulatory compliance or for process control measurement.

Abstract: An improved extractive reagent composition and method for extracting an immunosuppressant drug, such as sirolimus, tacrolimus or cyclosporine, from blood samples while yielding a test sample extract that has low vapor pressure and is compatible with immunoassay components. The inventive reagent composition comprises dimethyl sulfoxide (DMSO), at least one divalent metal salt and water. The sample extracts resulting from use of each of these combinations have low vapor pressure and are compatible with immunochemistry assays.

Abstract: Provided herein are compounds, methods of making the compounds and methods for the sensitive and selective detection of Hg2+ with the compounds, which are calix[4]arenes. In particular, compounds of Formula I, wherein the variables have the values described herein, may be added to a sample to be tested for Hg2+. The compound of Formula (I) fluoresces strongly in the absence of Hg2+ but is quenched upon binding of Hg2+ to form a complex. The decrease in fluorescence may be used to detect and quantify the amount of Hg2+ present in a sample. The disclosed compounds may also be used to selectively detect Hg2+ in samples containing other mono- or divalent metals.

Abstract: The invention relates to compositions and kits for homogeneous fluorescence polarization (anisotropy) assays for detecting and quantifying metal ions in solution. Metal-dependent binding of a fluorescent ligand to an unlabeled macromolecule effects a measurable change in anisotropy as will the binding of metal ions to a fluorescent labeled macromolecule. Binding of the fluorescent ligand to the unlabeled macromolecule is metal dependent with the change in anisotropy being proportional to the concentration of bound metal ions. Conversely, if the fluorescent label is first conjugated to a macromolecule and the macromolecule is subsequently stripped of metal ion, it may then be used to signal binding of metal ions. The covalently bound fluorescent label exhibits changes in anisotropy proportional to the concentration of bound metal ions. Kits comprise a fluorescent molecule and a macromolecule.

Abstract: Provided are a target biomaterial detecting kit and a method of detecting the target biomaterial. The target biomaterial detecting kit includes a guided mode resonance filter comprising a substrate transmitting or reflecting light, a grating layer formed on the substrate, and a capture layer formed on the grating layer to capture a target biomaterial; and a nano complex comprising a nanoparticle head and a connection tail. Therefore, the wavelength peak of a reflection/transmission spectrum of light coming from the guided mode resonance filter can be largely shifted, and thus the presence and quantity of a target biomaterial can be easily detected. Moreover, although the amount of the target biomaterial is small, the target biomaterial can be reliably detected.

Abstract: The invention relates to an apparatus and to a method for detecting and/or quantifying mercuric ions, Hg2+. The apparatus of the invention is of the type comprising an electrical device comprising two electrodes and a substrate comprising at least one surface made of an organic or inorganic semiconductor material, the electrodes being in electrical contact with said organic or inorganic semiconductor material, and a device for measuring the variation in the conduction current between the two electrodes, and wherein at least one compound which complexes mercuric ions Hg2+, selected from a dithia-dioxa-monoaza crown ether compound, an N,N-di(hydroxyethyl)amine, an N,N-di(carboxyethyl)amine, and mixtures of two at least of these compounds, is bonded to said semiconductor material or to an electrode of said electrical device. The invention finds application in the field of the detection of mercuric ions, in particular.

Abstract: The present invention is directed to methods and products related to carbodithioate ligands bonded to surfaces. The invention is further directed to molecular and biomolecular sensing methods based on analyte recognition by carbodithioate ligands bonded to surfaces.

Abstract: Novel biofunctionalized quantum dots include a mercaptoalkanoic acid linked to the surface of a nanocrystalline core and a bio-functional group linked to the surface. Biofunctionalized quantum dots are made by a novel synthesis method. Biofunctionalized quantum dots can be used in imaging or therapy applications.

Abstract: A method for analyzing a dithiocarbamate pesticide, which can ensure analytical precision with both ease and promptness is provided. The method for analyzing a dithiocarbamate pesticide comprises adding a crude drug, a preparation containing the same, or a treated product thereof, an aqueous acid catalyst solution, L-cysteine or a salt thereof, and an organic solvent for extraction to a reaction vessel, sealing the vessel, carrying out microwave irradiation, digesting a dithiocarbamate pesticide existing in the crude drug or the preparation containing the same into carbon disulfide, carrying out fractional extraction using the above organic solvent, and then analyzing the extract.

Abstract: A method for selectively orienting molecules on a surface of a solid support. The method includes the steps of: (a) attaching a linker molecule to the surface of the solid support, the linker molecule including a head group that is capable of binding to the solid support, and a tail group that is capable of chelating to a metal ion; (b) subsequently treating the solid support with a solution containing the metal ion; (c) attaching a metal ion chelating tag to the molecules to form tagged molecules; and (d) capturing the tagged molecules on the solid support by contacting it with the tagged molecules to form a monolayer of molecules on the surface of the solid support in which a majority of the molecules are held in the same orientation with respect to the surface. The invention also provides a sensor chip formed using the methods of the invention.

Abstract: Methods for rapid sensing of dissolved toxic heavy metals use a hybrid inorganic material (“HIM”), which is synthesized from hydrated iron oxide (“HFO”) and calcium magnesium silicate. HIM thus synthesized is used in sensing dissolved toxic heavy metals. Water containing toxic heavy metals (e.g., lead, copper, zinc, nickel, etc.) is passed through a sorbent bed of HIM, whereupon it shows a sharp drop in pH after a certain length of time. The presence of HFO and calcium magnesium silicates in HIM synergistically provide a precipitous drop in pH, which is characteristic of the concentration and type of toxic heavy metal. Therefore, observing a change in pH indicates the presence and identity of heavy metal ions in a test water sample.

Abstract: The present invention provides a metal chelator and methods that facilitate binding, detecting, monitoring and quantitating of heavy metal ions in a sample.

Abstract: The present invention provides a sensor for detecting mercury, comprising: a first polynucleotide, comprising a first region, and a second region, a second polynucleotide, a third polynucleotide, a fluorophore, and a quencher, wherein the third polynucleotide is optionally linked to the second region; the fluorophore is linked to the first polynucleotide and the quencher is linked to the second polynucleotide, or the fluorophore is linked to the second polynucleotide and the quencher is linked to the first polynucleotide; the first region and the second region hybridize to the second polynucleotide; and the second region binds to the third polynucleotide in the presence of Hg2+ ions.