Zn, Cd, Hg, Sc, Y, Or Actinides, Or Lanthanides Patents (Class 436/81)
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Publication number: 20100144043Abstract: A fluorescent sensor compound based on a perylene core is described and disclosed. The fluorescent sensor compound for detecting mercury can have a structure I: where A and A? are linking groups, B and B? are binding ligands which are selective for binding with Hg2+, and R1 through R8 are side groups. These fluorescence sensor materials are robust against photobleaching, while still providing exceptional detection sensitivity and selectivity.Type: ApplicationFiled: December 9, 2009Publication date: June 10, 2010Inventors: Ling Zang, Yanke Che
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Patent number: 7727767Abstract: Disclosed is a method for the quantitative analysis of a metal element contained in a resin material, which permits quantitatively analyzing the harmful substance such as lead contained in a resin material, comprising decomposing the resin material within a container having at least the inner surface formed of a glassy carbon in the presence of an aqueous solution of an oxidizing acid, heating the organic residue of the decomposed resin material so as to convert the residue into an ash, and quantitatively measuring the metal element contained in the organic residue converted into the ash.Type: GrantFiled: September 8, 2006Date of Patent: June 1, 2010Assignee: Kaushiki Kaisha ToshibaInventor: Miyuki Takenaka
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Publication number: 20100099195Abstract: The present invention provides devices, kits, and methods for determining the zinc level in a fluid sample of a subject. Such determination is useful in screening for the presence of or the increased risk of having prostate cancer.Type: ApplicationFiled: January 25, 2008Publication date: April 22, 2010Applicant: ANDRO DIAGNOSTICSInventor: Christopher Frederickson
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Patent number: 7691638Abstract: The present invention is directed to methods for determining electron transfer rates in systems involving metalloproteins. Metalloprotein/substrate electron transfer rates as well as metalloprotein self exchange rates may be modeled. Such electron transfer rates are useful in smart drug design and enzyme engineering.Type: GrantFiled: April 3, 2003Date of Patent: April 6, 2010Assignee: University of Iowa Research FoundationInventors: Johna Leddy, Shelley D. Minteer
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Publication number: 20100068817Abstract: Disclosed herein are methods of detecting metal ions in a sample using functionalized nanoparticles. More specifically, functionalized nanoparticles are used to selectively detect metal ions in a sample using changes in melting temperature of hybridized oligonucleotides on functionalized nanoparticles. The melting temperature can be detected using absorbance, color change, or both. In some cases, the concentration of the metal ion in the sample can be determined. Concentrations of metal ion of as little as 20 ppb (about 100 nM) can be detected using the disclosed methods.Type: ApplicationFiled: November 8, 2007Publication date: March 18, 2010Applicant: NORTHWESTERN UNIVERSITYInventors: Chad A. Mirkin, Jae-Seung Lee, Min Su Han
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Publication number: 20100022011Abstract: The present invention provides sensors and methods for determination of an analyte. The analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material upon exposure to an analyte. In some embodiments, the analyte and the emissive material may interact via a chemical reaction, or other chemical, biochemical or biological interaction (e.g., recognition), to form a new emissive species. In some cases, the present invention may be used for the detection of analytes such as explosives (e.g., RDX, PETN). Methods of the present invention may be advantageous in that the high sensitivity of luminescence (e.g., fluorescence) spectroscopy can allow for the reliable detection of small changes in luminescence intensity.Type: ApplicationFiled: October 16, 2006Publication date: January 28, 2010Applicant: Massachusetts Institute of TechnologyInventors: Timothy M. Swager, Trisha L. Andrew, Samuel W. Thomas, Jean Bouffard
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Patent number: 7651858Abstract: This invention provides methods of using ion-detecting microspheres containing an ionphore and a chromoionphore in clinical laboratory instrumentation such as flow cytometry for sample analysis. In one embodiment, the microspheres are contacted with a flowing stream of a sample under conditions that allow the ion-selective ionophores to complex with the ions in the sample, and to cause deprotonation of the chromoionophore. The complexes are then exposed to an excitation wavelength light source suitable for exciting the deprotonated chromoionophore to emit a fluorescence signal pattern. Detection of the fluorescence signal pattern emitted by the deprotonated chromoionophore in microspheres containing the complexes allows for determination of the presence of the target ions in the sample. In one embodiment, lead ion-detecting microspheres are provided that can detect nanomolar levels of lead ions with response times on the order of minutes.Type: GrantFiled: July 17, 2007Date of Patent: January 26, 2010Assignees: Auburn University, Beckman Coulter, Inc.Inventors: Eric Bakker, Martin Telting-Diaz, Mike Bell
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Patent number: 7648843Abstract: This invention pertains to a surface ligand; preparation of the ligand; colloidal nanoparticle, such as quantum dot bearing one or more of the ligand; and a bioconjugate characterized by a nanoparticle bearing one or more of the ligand conjugated to a biomolecule. The ligand is characterized by the presence of a first module containing atoms that can attach to an inorganic surface; a second module that imparts water-solubility to the ligand and to the inorganic surface that may be attached to the ligand; and a third module that contains a functional group that can, directly or indirectly, conjugate to a biomolecule. Order of the modules can be different and other modules and groups can be on the ligand. Preparation of the ligand includes the steps of reacting a compound having atoms that can attach to an inorganic surface with a water-solubilizing compound that imparts the property of water-solubility to the ligand and the inorganic surface to which it may be attached and purification thereof.Type: GrantFiled: July 10, 2007Date of Patent: January 19, 2010Assignee: The United States of America as represented by the Secretary of the NavyInventors: Harry Tetsuo Uyeda, Hedi M Mattoussi, Igor L Medintz
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Patent number: 7648838Abstract: Provided is a lysis method for cells or viruses, including: immobilizing a metal-ligand complex on a solid support; and mixing the complex immobilized on the support with a cell or virus solution. According to the lysis method, by immobilizing a chemical on a solid support to perform cell lysis, the dilution problem according to the addition of a cell lysis solution can be resolved and a separate process of removing the chemical is not required so as to reduce the steps upon LOC implementation. In addition, since a variety of solid supports, such as chips, beads, nanoparticles etc. can be used, cell lysis apparatuses of various forms can be fabricated.Type: GrantFiled: November 4, 2005Date of Patent: January 19, 2010Assignee: Samsung Electronics Co., Ltd.Inventors: Chang-eun Yoo, Joon-ho Kim, Kyu-youn Hwang, Hun-joo Lee, Hee-kyun Lim, Soo-min Ma, Nam Huh, Soo-suk Lee
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Patent number: 7632651Abstract: Systems for detecting molecular modifications and the presence and/or activity of enzymes and/or other agents involved in facilitating or otherwise regulating such modifications.Type: GrantFiled: September 30, 2005Date of Patent: December 15, 2009Assignee: MDS Analytical Technologies (US) Inc.Inventors: Annegret Boge, J. Richard Sportsman, Elizabeth Gaudet, George G. Yi
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Patent number: 7615377Abstract: The present invention is directed, in part, to fluorescein-based ligands for detection of metal ions, and methods of making and using the same.Type: GrantFiled: August 27, 2004Date of Patent: November 10, 2009Assignee: Massachusetts Institute of TechnologyInventors: Stephen J. Lippard, Elizabeth Marie Nolan
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Patent number: 7614315Abstract: A probe for measuring mercury emissions in a flue gas. The probe contains a novel cartridge for holding one or more sorbent traps, which cartridge is easily removed and inserted on-site with reduced danger of sorbent trap damage.Type: GrantFiled: February 15, 2008Date of Patent: November 10, 2009Assignee: Shaw Intellectual Property Holdings, Inc.Inventor: Randall Moore
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Patent number: 7611903Abstract: A system for quantitatively reducing oxide gases. A pre-selected amount of zinc is provided in a vial. A tube is provided in the vial. The zinc and the tube are separated. A pre-selected amount of a catalyst is provided in the tube. Oxide gases are injected into the vial. The vial, tube, zinc, catalyst, and the oxide gases are cryogenically cooled. At least a portion of the vial, tube, zinc, catalyst, and oxide gases are heated.Type: GrantFiled: September 11, 2002Date of Patent: November 3, 2009Assignee: Lawrence Livermore National Security, LLCInventors: John S. Vogel, Ted J. Ognibene, Graham S. Bench, Graham F. Peaslee
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Patent number: 7604997Abstract: Wipes, methods and kits useful for testing and/or removal of metal from surfaces (such as, dermal surfaces) are disclosed. Exemplar wipes, including the combination of a three-dimensionally textured absorbent support, a cationic surfactant, and a weak acid, are disclosed. In some examples, the cationic surfactant is isostearamidopropyl morpholine lactate (ISML), and the weak acid is citric acid.Type: GrantFiled: January 18, 2005Date of Patent: October 20, 2009Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Eric J. Esswein, Mark F. Boeniger, Kevin E. Ashley
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Publication number: 20090247473Abstract: Certain thiol and acylthiol compounds inhibit retrovirus growth by attacking the highly conserved zinc finger regions of essential viral proteins. These compounds, compositions containing them, and methods of using them to treat retroviral infections such as HIV are described. These compounds are also useful for preparation of vaccines comprised of inactivated retroviruses such as HIV, prevention of the transmission of such retroviruses, and detection of retroviral proteins.Type: ApplicationFiled: March 30, 2009Publication date: October 1, 2009Applicant: THE GOVERNMENT OF THE U.S.A.,as represented by the Secretary of the Dept. of Health & Human ServicesInventors: John K. Inman, Atul Goel, Ettore Appella, Jim Turpin, Marco Schito
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Patent number: 7531134Abstract: A method of directed automated analysis of a plurality of analytes of a process solution includes providing a sample of the process solution containing a plurality of the analytes, admixing an enriched isotope spike for each of the plurality of analytes to be analyzed with the process solution sample thereby effecting admixture of the enriched ratio of isotopes with the naturally occurring ratio of each analyte to be analyzed, creating ions from the spikes, introducing the ions into a mass spectrometer for determination of the identity and quantity of each analyte and delivering the information to a microprocessor. If desired, the process solution sample may be diluted and/or subjected to the addition of reagents or standards prior to initiation of the analysis. The ions may be created by an atmospheric pressure ionization interface. The information obtained is processed in a computer which serves to control other portions of the practice of the method.Type: GrantFiled: March 8, 2002Date of Patent: May 12, 2009Assignee: Metara, Inc.Inventors: Marc R. Anderson, Michael J. West, Howard M. Kingston, Larry N. Stewart
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Publication number: 20090111189Abstract: An apparatus and method for the detection and quantitation of metals and metalloids in a sample by derivatization are provided. In particular, the apparatus and method relates to analysis of mercury in a sample by derivatization of the inorganic and organic mercury species into elemental mercury and organo-mercury hydrides using sodium borohydride.Type: ApplicationFiled: October 27, 2008Publication date: April 30, 2009Applicant: ALBERTA RESEARCH COUNCIL INC.Inventor: Stuart SCHROEDER
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Patent number: 7521249Abstract: The present invention relates to the preparation of a sample. Preferably, the sample is a sample to be analyzed, for example for ingredient content, etc. Preferred samples include foods, cosmetics, paints, coatings, adhesives, tanning agents, fabrics, chemical compositions, dyestuffs, samples subject to forensic studies, etc. Samples prepared according to the invention method are digested in sulfuric acid, nitric acid, and one or more fluoride salts selected from LiF, NaF, RbF, CsF and KF and then preferably subjected to analysis for metal content, etc, for example using atomic absorption (“AA”) and inductively coupled plasma (“ICP”).Type: GrantFiled: December 7, 2004Date of Patent: April 21, 2009Assignee: L'OrealInventors: Jacob Rosen, Gregory Shmuylovich
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Publication number: 20090098656Abstract: A mercury ionic gas standard generator for use in the continuous emissions monitoring of exhaust flue gas streams is disclosed. More specifically, the mercury ionic gas standard generator uses a reservoir being coated with an inert silicon-based coating for transporting a volume of an aqueous ionic mercury solution to a liquid mass flow controller and vaporizer.Type: ApplicationFiled: October 15, 2007Publication date: April 16, 2009Inventors: Mark Wayne Holt, William Howard Eberhardt
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Patent number: 7517701Abstract: Systems, including compositions, kits, and methods, particularly for photoluminescence applications. The systems may include, among others, (1) organic chelators, (2) complexes between the chelators and lanthanide ions, and (3) precursors, derivatives, and uses thereof. The chelators may include a 1,4,7,10-tetraazacyclododecane ring system, for example, having the formula: Here, R1, R2, and R3 are substituents of the tetraazacyclododecane ring system, that is further substituted at the 10-position by a sensitizer Z that is typically a polyheterocyclic ring system. The organic chelator may be capable of forming a luminescent complex with a lanthanide ion, and is optionally further substituted by a reactive functional group or a conjugated substance. The resulting lanthanide complex may be useful in luminescence-based assays, such as energy transfer assays, among others.Type: GrantFiled: October 14, 2005Date of Patent: April 14, 2009Assignee: MDS Analytical Technologies (US) Inc.Inventors: David Parker, Paul Atkinson, Filip Kielar, Annegret Boge, J. Richard Sportsman, Elizabeth Gaudet, George G. Yi
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Patent number: 7494820Abstract: Luminescent chemical reagents that include complexes of rare earth metals with ligands such as aromatic heterocyclic nitrogen-containing compounds and semi-aromatic oxygen-containing compounds are used to detect small quantities of complex substances such as pharmaceuticals, metabolites, and microorganisms in complex sample mixtures.Type: GrantFiled: March 11, 2005Date of Patent: February 24, 2009Assignee: Bioveris CorporationInventors: Hongjun Yang, Nicholas Cairns
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Patent number: 7491544Abstract: Zn(II) is selectively detected in a sample by contacting the sample with a tripodal ligand with a piperidine or quinuclidine scaffold, one of which acts as a zinc sensor, in which the rigidity of the ligand scaffold is increased. The rigidity of the ligand scaffold can be increased by adding aromatic groups or cyclic hydrocarbon groups. Examples of aromatic groups include naphthalene and the like. Examples of cyclic groups include nitrogen-substituted cyclohexane and cyclohexene such as piperidine.Type: GrantFiled: May 20, 2003Date of Patent: February 17, 2009Assignee: New York UniversityInventors: James Canary, Zhaohua Dai
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Patent number: 7491545Abstract: A highly selective and sensitive of a carbonic anhydrase-based method for measurement of zinc ion by an excitation ratiometric format based on resonance energy transfer: i.e., where the zinc ion level is transduced as the ratio of fluorescence intensities excited at two different excitation wavelengths, is provided. The method can be used very well in a fluorescence microscopy format. A detection limit of about 10 pM in zinc buffered systems, a ten to one thousand-fold improvement on the Fura indicators (which respond to Ca and Mg as well), and a one hundred thousand-fold improvement on the recently described FuraZin-1 is achieved.Type: GrantFiled: September 30, 2003Date of Patent: February 17, 2009Inventors: Richard Thompson, Michele Cramer, Carol Ann Fierke, Hui Hui Zeng, Rebecca Bozym
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Publication number: 20090029389Abstract: The present invention provides fluorogenic compounds for the detection of target metal ions wherein the compounds exhibit a Stokes shift greater than 50 nm and the detectable signal is modulated by photoinduced electron transfer (PET). The present compounds consist of three functional elements, the ion sensing moiety (chelating moiety), the reporter moiety (fluorophore or fluorescent protein) and spacer or linker between the sensing and reporter moieties of the present compound that allows for PET upon binding of a metal ion and excitation by an appropriate wavelength.Type: ApplicationFiled: July 25, 2008Publication date: January 29, 2009Applicant: INVITROGEN CORPORATIONInventors: Kyle Richard Gee, Vladimir Martin
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Publication number: 20090017545Abstract: The present invention is a method for calorimetrically determining a metal in a sample using a chelating coloring agent, characterized by coexistence of a masking agent for iron, copper or nickel. Also, the present invention is a reagent for calorimetrically determining a metal in a sample using a chelating coloring agent, characterized by inclusion of a masking agent for iron, copper and/or nickel. Further, the present invention is a masking agent for iron, copper and/or nickel and a method for reducing positive errors due to iron, copper or nickel contained in a sample.Type: ApplicationFiled: February 22, 2007Publication date: January 15, 2009Applicant: Shino-Test CorporationInventors: Kazuhiko Higurashi, Naomi Iizuka
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Patent number: 7476738Abstract: The present invention provides a method for confirming existence of a phosphoric acid monoester compound (peptide, saccharine and the like) and easily identifying the molecular weight thereof even among biological samples including a plurality of compounds, and an additive for a mass spectrometry used for the method. In the method according to the present invention, a complex compound exhibiting extremely high coordination ability to a phosphoric acid monoester group and configured of single kind of zinc isotopes is used to obtain a plurality of mass spectrum data, and then the data are compared.Type: GrantFiled: December 24, 2003Date of Patent: January 13, 2009Assignee: NARD Institute Ltd.Inventors: Tohru Koike, Norio Minami, Akihiko Kawasaki
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Publication number: 20090011512Abstract: Embodiments of the invention relate generally to systems used to measure mercury in gaseous emissions. In one aspect, the invention is directed to the use of silicon carbide as material for a thermal pyrolysis unit. In another aspect, at least one of silicon nitride, silicon boride, and/or boron nitride is used as material for a thermal pyrolysis unit. In another aspect, the invention is directed to an improved pyrolyzer design, in which a thermal pyrolysis unit comprises a tailpiece that allows water to be injected at the heated exit of the thermal pyrolysis unit. In another aspect, the invention is directed to the use of a coalescing filter in a scrubbing unit. In another aspect, the invention is directed to the use of a hydrophobic filter element in a scrubbing unit. One or more of these elements may be used in a conditioning module of a continuous emissions monitoring system, for example.Type: ApplicationFiled: September 9, 2008Publication date: January 8, 2009Applicant: TEKRAN INSTRUMENTS CORPORATIONInventors: Frank H. Schaedlich, Daniel R. Schneeberger
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Patent number: 7473558Abstract: The present invention teaches a marker useful for detection and measurement of free radical damage. Specifically, the invention takes advantage of alterations which occur to the N-terminus of the albumin molecule, a circulating protein in human blood, in the presence of free radicals. These alterations affect the ability of the N-terminus of the albumin molecule to bind metals. Methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of an albumin containing sample, analysis and measurement of the ability of albumin to bind exogenous cobalt, detection and measurement of the presence of copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following free radical damage.Type: GrantFiled: August 30, 2002Date of Patent: January 6, 2009Assignee: Ischemia Technologies, Inc.Inventors: David Bar-Or, Edward Lau
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Publication number: 20080317835Abstract: Assays are preformed to determine nutrient deficiency levels in an individual to address the deficiencies and improve health and longevity. Nutraceutical and cosmeceutical products containing nanoencapsulated active ingredients are provided, in addition to dietary, exercise, sleep, and other lifestyle recommendations.Type: ApplicationFiled: June 20, 2007Publication date: December 25, 2008Inventors: Nazli Azimi, Mohammad Saeed Kharazmi
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Patent number: 7454945Abstract: A calibration assembly generates elemental mercury and oxidized mercury for calibrating components of a mercury monitoring system, including making necessary adjustments to efficiencies of a mercury compound converter and an elemental mercury detector. The calibrator generates an elemental mercury sample having a known elemental mercury concentration, [Hg0]1 and combines an oxidizing component with the elemental mercury sample, thereby producing a reduced concentration of elemental mercury [Hg0]2 within the sample. The calibrator measures the concentration of elemental mercury [Hg0]2 within the sample and calculates a difference between the known elemental mercury concentration, [Hg0]1 and the reduced concentration [Hg0]2. The difference between [Hg0]1 and [Hg0]2 is substantially equal to the concentration of oxidized mercury produced by the calibrator.Type: GrantFiled: September 27, 2006Date of Patent: November 25, 2008Assignee: Thermo Electron, Inc.Inventors: Dieter Kita, James H. Grassi, Jeffrey Socha, Bryan A. Marcotte
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Patent number: 7452728Abstract: Methods and systems for the concentration and removal of metal ions from aqueous solutions are described, comprising treating the aqueous solutions with photoswitchable ionophores.Type: GrantFiled: May 20, 2004Date of Patent: November 18, 2008Assignee: Intel CorporationInventors: Bob E. Leet, Robert P. Meagley, Michael D. Goodner, Michael L. McSwiney
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Publication number: 20080274463Abstract: Disclosed embodiments concern quantifying a biomolecule conjugated to a nanoparticle. Quantifying typically comprises determining the number of biomolecules per nanoparticle. Any suitable biomolecule can be used, including but not limited to, amino acids, peptides, proteins, haptens, nucleic acids, oligonucleotides, DNA, RNA, and combinations thereof. A single type of biomolecule may be conjugated to the nanoparticle, more than one biomolecule of a particular class may be conjugated to the nanoparticle, or two or more classes of biomolecules may be conjugated to the nanoparticle. Certain disclosed embodiments comprise enzymatically or chemically digesting a biomolecule conjugated to the nanoparticle, or displacing a biomolecule using ligand-exchange chemistry.Type: ApplicationFiled: May 4, 2007Publication date: November 6, 2008Inventors: Xiao-Bo Chen, Christopher Bieniarz, Michael Farrell
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Publication number: 20080261314Abstract: A compound represented by the following general formula (I) or a salt thereof: wherein R1 represents hydrogen atom, an alkyl group, an alkoxy group, or hydroxy group; R2 represents a group represented by the following formula (A): wherein X1 to X4 represent hydrogen atom, an alkyl group, or 2-pyridylmethyl group, and m and n represent 0 or 1; Y represents a single bond or —CO—; R3 represents a carboxy-substituted aryl group, a carboxy-substituted heteroaryl group, benzothiazol-2-yl group, or 5-oxo-2-thioxo-4-imidazolyzinylidenmethyl group], and a fluorescent probe for zinc which comprises said compound or a salt thereof.Type: ApplicationFiled: March 28, 2008Publication date: October 23, 2008Applicants: DAIICHI PURE CHEMICALS CO., LTD., TETSUO NAGANOInventors: Tetsuo NAGANO, Kazuya Kikuchi, Tomoya Hirano, Satoko Maruyama
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Patent number: 7422907Abstract: A process for measuring the mercury concentration within a hydrocarbon is provided that enables the mercury concentration to be measured simply and quickly, and with good reliability and good reproducibility. A process for measuring the mercury concentration within a hydrocarbon includes the steps of placing and weighing the hydrocarbon in a sample boat 12 containing an adsorbent that contains a metal capable of forming an amalgam with mercury, and heating the hydrocarbon inside the sample boat 12 in a combustion furnace 13, together with the adsorbent, and measuring the quantity of mercury within the thus generated gas.Type: GrantFiled: February 4, 2005Date of Patent: September 9, 2008Assignee: Sekiyushigen Kaihstsu Kabushiki KaishaInventors: Hitomi Hirano, Shinichi Okada, Naohide Tsuzuki, Yoshio Yasuda
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Publication number: 20080188002Abstract: There is provided a method and apparatus for removing selenium oxide in a sample as well as a method and apparatus for measuring mercury in coal combustion exhaust gas by using the same. The apparatus for removing selenium oxide in a sample, comprising: (1) a heating introduction path for heating a sample, (2) a primary cooling unit having a flow path through which the heated sample flows countercurrently to cooling water, whereby the heated sample is mixed with, and cooled by, cooling water, (3) a secondary cooling unit having a spiral flow path for cooling the mixed gas and having a space for gas/liquid separation at the end of the spiral flow path, (4) a regenerator for introducing condensed water from the secondary cooling unit, and (5) a condensed water-cooling path for connecting the regenerator to the primary cooling unit.Type: ApplicationFiled: February 1, 2008Publication date: August 7, 2008Inventors: Junji Kato, Shigeyuki Akiyama, Fujio Koga, Koji Ishikawa
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Publication number: 20080182333Abstract: The present invention is a new class of fluorescent sensor with unprecedented sensitivity, selectivity and synthetic efficiency for the identification and qualitative and quantitative detection of transition metal ions. The chemosensing properties are based on an internal charge transfer mechanism or photo-induced electron transfer and are effective in vitro. The chemosensor comprises one or more electron donating dipyrrin functionalities linked to an electron withdrawing functionality. The chemosensor forms a stable transition metal complex through internal charge transfer between the electron donating functionality and the target transition metal, which results in measurable fluorescence. Specific examples for sensing zinc and copper ions are described.Type: ApplicationFiled: July 17, 2007Publication date: July 31, 2008Inventors: Paul A. Bentley, Yujiang Mei
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Patent number: 7399639Abstract: The present invention is directed, in part, to sensors for detecting metal ions, and methods of making and using the same.Type: GrantFiled: May 4, 2003Date of Patent: July 15, 2008Assignee: Massachusetts Institute of TechnologyInventors: Stephen J. Lippard, Carolyn Crystal Woodroofe
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Patent number: 7384789Abstract: Diamino polyacetate benzene compounds are used as a selective fluorescence probe, sensor, or binders for divalent metal ions. The compounds provide for uses as divalent metal ion sensors in diagnostic applications and binders for environmental and medical treatments.Type: GrantFiled: January 30, 2007Date of Patent: June 10, 2008Assignee: The University of North DakotaInventors: Anamitro Banerjee, Julius N. Ngwendson
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Publication number: 20080113359Abstract: An arsenic ion active DNAzyme includes a nucleotide sequence, which has a base sequence selected from ATCTCCTCCTGTTC (SEQ ID NO: 62), ATCTGCTCCTGTTC (SEQ ID NO: 63), ATCTCCTCATGTTC (SEQ ID NO: 64), ATCTCCTCTTGTTC (SEQ ID NO: 65), ATCTCCAACCTGTTC (SEQ ID NO: 66), and CCGTAGCGCAAAT (SEQ ID NO: 67). A mercury ion active DNAzyme includes a nucleotide sequence, which has a base sequence selected from AATTCCGTAGGTCCAGTG (SEQ ID NO: 68), AATTCCGTCGGTCCAGTG (SEQ ID NO: 69), AATTCCGCCGGTCCAGTG (SEQ ID NO: 70), GGTTCCGAGTCTCGCGTG (SEQ ID NO: 71), and CGTTCAAAAGGGGCACTG (SEQ ID NO: 72). Sensors incorporating the respective DNAzymes are also disclosed.Type: ApplicationFiled: August 29, 2007Publication date: May 15, 2008Inventors: Peter Adriaens, Raveender Vannela
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Patent number: 7368289Abstract: An apparatus, process, coating, and filter for the accurate measurement of total mercury concentration in flue gas. In a preferred aspect, the concentrations of both elemental and oxidized mercury are preserved by the apparatus for analysis. Accordingly, embodiments of the present apparatus and process can be used to determine regulatory compliance or for process control measurement.Type: GrantFiled: November 7, 2003Date of Patent: May 6, 2008Assignee: Perma Pure LLCInventors: Tom Baldwin, John Ward, III, Allan Budd
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Patent number: 7354553Abstract: An improved elemental mercury analyzer utilizes a fluorescence assembly in combination with a fluorescence quenching reduction mechanism to detect the concentration of elemental mercury within an emission gas sample, via fluorescence of the mercury within the gas sample, while minimizing fluorescence quenching of the gas sample. In one arrangement, the analyzer contains the emission gas sample under a vacuum or negative pressure while detecting fluorescence of the elemental mercury within the emission gas sample. By performing fluorescence detection of the emission gas sample at reduced pressure relative to the pressure of the as-sampled emission gas, the analyzer reduces the number of particle collisions within the emission gas sample over a certain period of time. Such collisional deactivation, and/or the addition of oxygen depleted gas such as nitrogen to the gas sample, reduces fluorescence quenching of the emission gas sample, improving accuracy of detection of mercury.Type: GrantFiled: May 2, 2005Date of Patent: April 8, 2008Inventors: Dirk Appel, James H. Grassi, Dieter Kita, Jeffrey Socha
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Patent number: 7344895Abstract: A process for synthesizing nanoparticles, in particular metal salt nanoparticles. To the synthesis mixture is added a modifying reagent which binds, by means of a first functional group, to the nanoparticle surface and which carries a second functional group for binding to molecules which are specifically selected in dependence on the subsequent use of the nanoparticles. This dispenses with a postsynthetic, separate, application-specific modification step. A new substance class, the pentaalkyl iminobis(methylenephosphono)carboxylates, are particularly suitable for this purpose.Type: GrantFiled: December 6, 2003Date of Patent: March 18, 2008Assignee: Bayer Technology Services GmbHInventors: Burkhard Köhler, Kerstin Bohmann, Werner Hoheisel, Markus Haase, Stefan Haubold, Christiane Meyer, Thorsten Heidelberg
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Publication number: 20080044913Abstract: Disclosed are a novel 8-hydroxyquinoline acetamide compound, an 8-hydroxyquinoline thioamide and use thereof. More specifically, disclosed are a novel 8-hydroxyquinoline thioamide compound suitable for use as a selective chemodosimeter that shows considerably high detection sensitivity to mercury ions, an 8-hydroxyquinoline acetamide compound as an intermediate thereof, preparation thereof, and a chemodosimeter for mercury ion-selective detection, the chemodosimeter comprising the 8-hydroxyquinoline thioamide compound. The compounds as disclosed herein exhibit considerably effective fluorescence specificity of an off-on type, detect a micromole of mercury ions from chemical and biological aqueous systems, and allow 100% desulfurization within 5 minutes, thus being considerably useful in the chemical industry.Type: ApplicationFiled: July 6, 2007Publication date: February 21, 2008Inventors: Suk Kyu CHANG, Ki Cheol Song, Jun Soo Kim, Sang Mi Park, Sang Doo Ahn, Jae Young Sung
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Patent number: 7332344Abstract: A method of detecting an analyte is described in which an up-converting luminescent species that is excited by absorption of long wavelength light is provided as a donor of energy to an acceptor species that can be bound to, or generated in proximity to, the luminescent species. The analyte either alters the proximity between the luminescent species and the acceptor species or alters the absorbance or luminescence properties of the acceptor species. The luminescent energy donor is excited with long wavelength light and transfers up-converted energy to the proximate acceptor species and this transfer of energy is detected by measurement of appropriate luminescence properties of either the donor or of the acceptor or both.Type: GrantFiled: February 28, 2002Date of Patent: February 19, 2008Assignee: Photonic Research Systems LimitedInventor: Christopher G. Morgan
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Patent number: 7297547Abstract: In one embodiment, a method of neutralizing the matrix of an acidic solution including at least one metal using a weak anion exchange resin is provided. The method includes the acts of: activating the weak anion exchange resin with a weakly acidic metal complexing reagent, the weakly acidic metal complexing reagent partially disassociating into protons and metal complexing anions, whereby some functional groups in the weak anion exchange resin are protonated and bind with the metal complexing anions; and neutralizing a sample of the acidic solution with the activated weak anion exchange resin.Type: GrantFiled: July 11, 2005Date of Patent: November 20, 2007Assignee: Metara, Inc.Inventor: Harmesh K. Saini
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Patent number: 7285419Abstract: Methods of analyzing mercury containing samples for inorganic and organomercurial complexes are disclosed. The methods are highly sensitive and are especially suited to samples containing significant amounts of organic matter. Kits and devices for mercury analysis are also disclosed.Type: GrantFiled: June 11, 2002Date of Patent: October 23, 2007Assignee: The Board of Trustees of the University of IllinoisInventors: Christopher W. Shade, Robert J. M. Hudson
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Patent number: 7267994Abstract: The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules. More particularly, the invention provides Element Coded Affinity Tags comprising a metal chelate and a metal ion and methods of using the tags to detect, analyze, and identify biomolecules including polypeptides, nucleic acids, lipids, and polysaccharides.Type: GrantFiled: May 24, 2004Date of Patent: September 11, 2007Assignee: Regents of the University of CaliforniaInventors: Claude F. Meares, Carlito B. Lebrilla, Nathaniel G. Butlin, Sarah M. Cheal, Todd M. Corneillie, Susan Lee, Paul A. Whetstone, Nicolas L. Young
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Patent number: 7256049Abstract: Device and methods for the removal of phospholipids from biological samples are disclosed and described. Removal of phospholipids may be desirable for the analysis of the phospholipids themselves, or to prevent the phospholipids from conflicting with and effectively masking other analytes in the sample for which identification or quantification is sought.Type: GrantFiled: September 4, 2003Date of Patent: August 14, 2007Assignee: Tandem LabsInventors: Patrick Kevin Bennett, Kenneth Charles Van Horne
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Patent number: 7247489Abstract: This invention provides methods of using ion-detecting microspheres containing an ionphore and a chromoionphore in clinical laboratory instrumentation such as flow cytometry for sample analysis. In one embodiment, the microspheres are contacted with a flowing stream of a sample under conditions that allow the ion-selective ionophores to complex with the ions in the sample, and to cause deprotonation of the chromoionophore. The complexes are then exposed to an excitation wavelength light source suitable for exciting the deprotonated chromoionophore to emit a fluorescence signal pattern. Detection of the fluorescence signal pattern emitted by the deprotonated chromoionophore in microspheres containing the complexes allows for determination of the presence of the target ions in the sample. In one embodiment, lead ion-detecting microspheres are provided that can detect nanomolar levels of lead ions with response times on the order of minutes.Type: GrantFiled: March 7, 2003Date of Patent: July 24, 2007Assignees: Auburn University, Beckman Coulter, Inc.Inventors: Eric Bakker, Martin Telting-Diaz, Mike Bell
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Patent number: 7229842Abstract: Compositions are disclosed comprising (a) a metal chelate wherein the metal is selected from the group consisting of europium, terbium, dysprosium, samarium osmium and ruthenium in at least a hexacoordinated state and (b) a compound having a double bond substituted with two aryl groups, an oxygen atom and an atom selected from the group consisting of oxygen, sulfur and nitrogen wherein one of the aryl groups is electron donating with respect to the other. Such composition is preferably incorporated in a latex particulate material. Methods and kits are also disclosed for determining an analyte in a medium suspected of containing the analyte. The methods and kits employ as one component a composition as described above.Type: GrantFiled: May 19, 2005Date of Patent: June 12, 2007Assignee: Dade Behring Marburg GmbHInventors: Sharat Singh, Edwin F. Ullman