Plural Nitrogen In The Same Ring (e.g., Barbituates, Creatinine, Etc.) Patents (Class 436/98)
  • Patent number: 10656160
    Abstract: A method of quantitatively determining the concentration of at least one analyte in a sample by: (i) adding a portion of the sample to a first analyte assay formulation and to an analyte assay reference formulation to generate a first analyte sample and analyte reference sample and determining the concentration of the at least one analyte in the sample; and/or (ii) adding a portion of the sample to a second analyte assay formulation and determining the concentration of the at least one analyte in the sample, as well as formulations, kits of parts, systems and computer implemented methods associated with the method.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: May 19, 2020
    Assignee: Nitto Denko Corporation
    Inventors: Xiaojun Chen, Yingsong Wang, Pei Shan Ho, Xi Er Yeo
  • Patent number: 10591493
    Abstract: Compounds are of the formula (Ia), (Ib), (Ic), or are stereoisomers thereof, wherein: R1 is hydrogen, (C1-C20)alkyl; (C3-C20)alkenyl; (C3 C20)alkynyl; (C1-C6)alkyl-O—; (C3-C20)cycloalkyl; (C1 C20)haloalkyl; (C6-C20)aryl optionally substituted; (C6-C20)heteroaryl optionally substituted; R2 and R2? are hydrogen; (C1-C20)alkyl; (C1-C6)alkyl-O—; (C1-C6)haloalkyl; halogen; cyano; and nitro; Z1 to Z4 are diradicals of formula (III) wherein A1 and A2 are O— or NR3-, wherein R3 is selected from the group consisting of hydrogen and (C1-C20)alkyl; and G is (C1-C6)alkyl; —P(?S)R5-; —P(?O)R4; —P(?O)(OR4)-; —P(?O)(NR6R7)-; —S(?O)2-; S(?O)—; or —C(?O)—; and Y1 to Y4 are (C1-C8)alkyl; (C3-C7)cycloalkyl; (C6-C20)aryl optionally substituted; or (C6-C20)heteroaryl optionally substituted; and FG1 and FG2 are H, OH, or NHR8.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: March 17, 2020
    Assignees: FUNDACIO INSTITUT CATALA D'INVESTIGACIO QUIMICA (ICIQ), INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS, UNIVERSITAT ROVIRA I VIRGILI
    Inventors: Louis Adriaenssens, Pau Ballester, Francisco Javier Andrade, Pascal Blondeau, Francesc Xavier Rius, Tomas De Aquino Guinovart Pavon, Daniel Hernandez Alonso
  • Patent number: 9770455
    Abstract: The present disclosure relates to methods for weight management in an individual in need thereof by determining the level of renal sufficiency of the individual and prescribing or administering a therapeutically effective amount of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine or a pharmaceutically acceptable salt, solvate or hydrate thereof to the individual, provided that the individual has a level of renal sufficiency selected from the group consisting of: no renal impairment, mild renal impairment, and moderate renal impairment.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: September 26, 2017
    Assignee: Arena Pharmaceuticals, Inc.
    Inventors: Christen M. Anderson, William R. Shanahan
  • Patent number: 9416152
    Abstract: The present invention relates to process for the preparation of azacitidine and its crystalline forms.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: August 16, 2016
    Assignees: DR. REDDY'S LABORATORIES LTD., DR. REDDY'S LABORATORIES, INC.
    Inventors: Praveen Cherukupally, Satish Kumar Vujjini, Ganesh Varanasi, Sreenadha Charyulu Kandala, Srinivas Areveli, Satyanarayana Raju Tirumalaraju
  • Patent number: 9176110
    Abstract: A histamine concentration level of a fish item is determined by illuminating the fish and analyzing the resulting spectral image data. Specifically, an algorithm is applied to the fish image data so that a histamine concentration value is calculated for every pixel of the fish image. A corresponding histamine concentration image of the fish is produced based on the collective histamine concentration values. The fish is accepted or rejected based on the collective histamine concentration values and/or the histamine concentration image. The histamine concentration image may be used to identify specific parts of a fish fillet that exceed (or do not exceed) a predetermined histamine concentration level.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: November 3, 2015
    Assignees: The United States of America, as represented by the Secretary of Agriculture, Headwall Photonics, Inc.
    Inventors: Moon S. Kim, Kuanglin Chao, David P. Bannon
  • Patent number: 9057698
    Abstract: Chemoselective derivatization of biological amines, carboxylic acids, aldehydes or ketones are employed in methods to detect a plurality of components, or members of a component, such as metabolites, that vary in molecular structure. The methods of the invention can be employed in aqueous and nonaqueous conditions.
    Type: Grant
    Filed: August 15, 2012
    Date of Patent: June 16, 2015
    Assignee: Brown University
    Inventors: Jason K. Sello, Kyle A. Totaro, Babajide O. Okandeji
  • Publication number: 20150132861
    Abstract: A diagnostic system is provided herein that includes an instrument comprising an electrochemiluminescence (ECL) detector, and a cartridge configured to fit within a portion of the instrument, wherein the cartridge includes at least one reagent including an ECL label and a blood collection holder. Also provided herein is a system that includes a diagnostic instrument, which includes a pump, an ECL detector, an incubator, a magnet, and an output device, and a cartridge configured to fit within a portion of the diagnostic instrument, a sample holder configured to fit within the cartridge, and a closed fluidic loop between the diagnostic instrument and the cartridge when the cartridge is fit within a portion of the diagnostic instrument, wherein the cartridge is configured to accept a sample from the sample holder and place the sample in fluidic communication with the diagnostic instrument via the closed fluidic loop.
    Type: Application
    Filed: May 15, 2013
    Publication date: May 14, 2015
    Applicant: Wellstat Diagnostics, LLC
    Inventors: Richard Alan Cook, Sang Cho, Charles Quentin Davis, Kevin E Dorsey, Jason Charles Harley, Jonathan Leland, Rober Krikor Matikyan, Sjef Otten, Jeffrey Howard Peterman, Brian B Thomas
  • Patent number: 8999970
    Abstract: The present disclosure relates to methods for weight management in an individual in need thereof by determining the level of renal sufficiency of the individual and prescribing or administering a therapeutically effective amount of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine or a pharmaceutically acceptable salt, solvate or hydrate thereof to the individual, provided that the individual has a level of renal sufficiency selected from the group consisting of: no renal impairment, mild renal impairment, and moderate renal impairment.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: April 7, 2015
    Assignee: Arena Pharmaceuticals, Inc.
    Inventors: Christen M. Anderson, William R. Shanahan
  • Patent number: 8999722
    Abstract: Sensors and methods for determination of analytes are provided. Analytes including explosives (e.g., RDX or PETN) may be determined by monitoring, for example, a change in an optical signal of a material upon exposure to the analyte. In some embodiments, the analyte and the material may interact via a chemical reaction to form a new emissive species. Embodiments described herein may provide inexpensive sensors with high selectivity and sensitivity.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: April 7, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Timothy M. Swager, Trisha L. Andrew
  • Publication number: 20150080263
    Abstract: The present invention is directed to methods for predicting a pregnant woman's risk of carrying a fetus with Down syndrome (Trisomy 21) or Trisomy 18. The methods are based on measuring one or more metabolites obtained from a pregnant woman's bodily fluid, such as blood or urine, and found to be predictive of Trisomy 21 or Trisomy 18.
    Type: Application
    Filed: April 12, 2013
    Publication date: March 19, 2015
    Inventors: Ray O. Bahado-Singh, Kypros Nicolaides
  • Publication number: 20150056711
    Abstract: Explosives detection polymers are provided that include a polyamine polymer, such as polyethylenimine, functionalized with a small molecule fluorophore. Methods for detecting an explosive material using polyamine polymers functionalized with a small molecule fluorophore are also provided. Sensors for explosive detection are provided that include a polyamine polymer functionalized with a small molecule fluorophore and a complementary analytical device.
    Type: Application
    Filed: March 21, 2013
    Publication date: February 26, 2015
    Applicant: University Of Connecticut
    Inventors: Yu Lei, Ying Wang
  • Patent number: 8956876
    Abstract: There is provided a method for quantitatively detecting 8-oxo 2?-deoxyguanosine in an aqueous sample solution with high sensitivity. A method for quantitatively detecting 8-oxo 2?-deoxyguanosine in an aqueous sample solution, including the steps of 1) immobilizing a fluorescent probe molecule showing a fluorescence response specific to 8-oxo 2?-deoxyguanosine on surfaces of fine particles via a spacer unit and bringing the sample solution into contact with the fine particles, and 2) measuring a physical property of the fine particles before and after the contact with the sample solution to determine a change in the physical property.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: February 17, 2015
    Assignee: TAS Project Co. Ltd
    Inventors: Shigeki Sasaki, Osamu Nakagawa, Zhichun Li, Atsushi Takaki, Sachiyo Saitoh
  • Publication number: 20150038522
    Abstract: To provide an anti-cancer agent sensitivity determination marker, which marker can determine whether or not the patient has a therapeutic response to the anti-cancer agent, and novel cancer therapeutic means employing the marker. The anti-cancer agent sensitivity determination marker, the anti-cancer agent including oxaliplatin or a salt thereof and fluorouracil or a salt thereof, contains one or more substances selected from among an amino-acid-metabolism-related substance, a nucleic-acid-metabolism-related substance, a substance in the pentose phosphate pathway, a substance in the glycolytic pathway, a substance in the TCA cycle, a polyamine-metabolism-related substance, 7,8-dihydrobiopterin, 6-phosphogluconic acid, butyric acid, triethanolamine, 1-methylnicotinamide, NADH, NAD+, and a substance involved in the metabolism of any of these substances.
    Type: Application
    Filed: February 22, 2013
    Publication date: February 5, 2015
    Applicants: KEIO UNIVERSITY, KABUSHIKI KAISHA YAKULT HONSHA
    Inventors: Yusuke Tanigawara, Akito Nishimuta, Junya Tsuzaki, Hiroyuki Takahashi
  • Publication number: 20150017733
    Abstract: The present invention provides methods for detecting and quantifying metabolites in a biological sample by measuring the concentration of a test metabolite in the sample and comparing that concentration against the concentration of the reference metabolite; enabling accurate metabolite concentration measurements to determine aberrant drug usage patterns. Also disclosed is an analytical testing device and related computer-assisted products for detecting and quantifying metabolites in a biological sample efficiently and accurately.
    Type: Application
    Filed: August 12, 2014
    Publication date: January 15, 2015
    Applicant: MARSHFIELD CLINIC, INC.
    Inventors: Michael E.M. Larson, Thomas M. Richards
  • Publication number: 20150017732
    Abstract: A colorimetric assay to detect certain compounds and a kit therefore are provided.
    Type: Application
    Filed: July 11, 2014
    Publication date: January 15, 2015
    Inventors: Tsunghsueh Wu, Charles Cornett
  • Publication number: 20150018244
    Abstract: The present invention pertains to the field of diagnostics for hyperthyroidism and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing hyperthyroidism. It also relates to a method for determining whether a compound is capable of inducing such hyperthyroidism in a subject and to a method of identifying a drug for treating hyperthyroidism. Furthermore, the present invention relates to a device and a kit for diagnosing hyperthyroidism.
    Type: Application
    Filed: March 7, 2013
    Publication date: January 15, 2015
    Applicant: BASF SE
    Inventors: Tilmann B. Walk, Bennard van Ravenzwaay, Werner Mellert, Eric Fabian, Volker Strauss, Hennicke Kamp, Jan C. Wiemer, Ralf Looser, Michael Manfred Herold, Alexandre Prokoudine
  • Publication number: 20150004713
    Abstract: Methods and materials for the detection of melamine in test samples such as foodstuffs are described. Embodiments of the invention comprise combining a test sample suspected of containing melamine with a particle that produces a colorimetric and/or turbidimetric signal that is dependent upon the concentration of melamine in the test sample. In certain embodiments of the invention, the particles and test sample are combined together with a chemical compound selected to induce the aggregation melamine in a manner that amplifies the colorimetric and/or turbidimetric signal of the assay. In some embodiments of the invention, the aggregation inducing agent is not physically coupled to the particles used in the assays. In other embodiments of the invention, the aggregation inducing agent is physically coupled to the particles used in these assays.
    Type: Application
    Filed: June 4, 2014
    Publication date: January 1, 2015
    Inventors: Na Li, Fang Wei, Huaping Li, Guillermo C. Bazan
  • Publication number: 20140349326
    Abstract: Apparatus and methods are provided for analyzing a medical condition of a user. The apparatus may include a user interface configured to receive user identification information inputted by the user, an analyzer, and a processor all disposed within a common housing. The analyzer is configured to receive a biological specimen from the user and to analyze the biological specimen to generate analysis information. The processor is configured to store and forward the analysis information and to receive prescription information. The apparatus may include a communication unit configured to transmit the user identification information and the analysis information to a doctor at a remote location for review and to receive the prescription information from the doctor. The apparatus then may dispense the prescribed medication or print a medication prescription.
    Type: Application
    Filed: February 6, 2013
    Publication date: November 27, 2014
    Inventor: Michael INGBER
  • Patent number: 8895313
    Abstract: Provided are certain benzothiazole, imidazothiazole, imidazopyrimidine and imidazopyridine compounds, including, for example: formula (I) and pharmaceutically and physiologically acceptable salts, hydrates, and solvates thereof. Such compounds can be used as diagnostic ligands or labels of tau protein and PHF.
    Type: Grant
    Filed: September 23, 2009
    Date of Patent: November 25, 2014
    Assignee: Wista Laboratories Ltd.
    Inventors: Steven John Kemp, Lynda Jane Storey, John Mervyn David Storey, Janet Rickard, Charles Robert Harrington, Claude Michel Wischik, Scott Clunas, Tobias Kerst Heinrich
  • Patent number: 8871520
    Abstract: The invention provides a method of detecting uracil. The method comprises reacting uracil with a compound represented by the formula (I) in the presence of an oxidant and a base to produce a fluorescent compound represented by the formula (II).
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: October 28, 2014
    Assignee: Nagasaki University
    Inventors: Masaaki Kai, Takayuki Shibata
  • Publication number: 20140315229
    Abstract: This invention relates to a testing system arrangement for assessing the level of a biochemical marker, comprising a disposable device (2) with a sample inlet (4) and a at least one visible detection compartment (5A, 5B), for detection of said bio-chemical marker, a mobile unit (8) including a digital camera arranged to capture a digital picture (60) of said at least one visible detection compartment (5A, 5B), software run on a processor for analysing said picture (60) to assess said level and means arranged to present the result (70) of said assessment in a display (8A) of or connected to, said mobile unit (8), wherein said disposable device (2) is arranged with at least one reference surface (12) having a predetermined colour setting that is known to said software to enable exact assessment of the colour within said detection compartment (5A, 5B) by the use of said reference surface (12) within said digital picture as a basis reference.
    Type: Application
    Filed: November 22, 2012
    Publication date: October 23, 2014
    Applicant: Calmark Sweden AB
    Inventors: Mathias Karlsson, Sofia Hiort Af Ornaes, Hjalmar Didrikson
  • Publication number: 20140308686
    Abstract: Methods for detecting abdominal aortic aneurysm (AAA) or predisposition to AAA in a apoE subject, methods for monitoring the efficacy of treatment of AAA in a subject, and methods for evaluating the severity of AAA or risk of AAA in a subject involve measuring the amount of tetrahydrobiopterin (H4B) present in the test sample and comparing it to the amount of H4B present in a standard or previous test sample. A decreased amount of H4B present in the test sample compared to the standard is indicative of AAA or predisposition to AAA. Treatment can be administered to the subject prior to a second time point, and an increased amount of H4B present in the second test sample compared to the first test sample is indicative of effective treatment of AAA. Candidates can be identified for further testing or monitoring for AAA, and/or for treatment for AAA.
    Type: Application
    Filed: October 11, 2012
    Publication date: October 16, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Hua Cai
  • Publication number: 20140242711
    Abstract: Methods are described for measuring the amount of a vitamin B2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin B2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.
    Type: Application
    Filed: May 2, 2014
    Publication date: August 28, 2014
    Applicant: Quest Diagnostics Investments Inc.
    Inventors: Changming Yang, Sum Chan
  • Publication number: 20140212981
    Abstract: Disclosed are methods and systems for the analysis of thiopurine drug metabolites in a sample using liquid chromatography/mass spectrometry.
    Type: Application
    Filed: December 19, 2013
    Publication date: July 31, 2014
    Applicant: Laboratory Corporation of America Holdings
    Inventors: Russell Philip Grant, Stacy Michelle Walker Dee
  • Patent number: 8785204
    Abstract: The invention provides a method of assaying for tetrahydrocannabinol in a body fluid. The method includes contacting a sample of body fluid with an imine capable of reacting with tetrahydrocannabinol to yield a quinone imine, and detecting the formation of a quinone imine, where the sample is contacted with the reagent compound at a pH of at least 10.5.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: July 22, 2014
    Assignee: Oxtox Limited
    Inventors: Dimitrios Konstantinos Kampouris, Patrick Robinson Huddleston, Craig Edward Banks
  • Patent number: 8778689
    Abstract: We disclose the synthesis and use of chiral ionic liquids based on a substituted pentose, furanose, hexose, or pyranose sugar. The compounds and processes to make or use them are provided.
    Type: Grant
    Filed: May 23, 2008
    Date of Patent: July 15, 2014
    Assignee: The University of the West Indies
    Inventors: Gurdial Singh, Patrice G. J. Plaza, Bhoomendra A. Bhongade
  • Publication number: 20140155341
    Abstract: The present invention relates to an in vitro method of diagnosis, prognosis and/or monitoring of pathologies caused by gliotoxin-producing fungi or their derivatives, characterized in that it is based on the detection of SS?-dimethyl-gliotoxin in a biological sample. Also relates to the use of the SS?-dimethyl-gliotoxin as marker for the diagnosis, prognosis and/or monitoring of pathologies caused by gliotoxin-producing fungi or their derivatives in a subject.
    Type: Application
    Filed: May 4, 2012
    Publication date: June 5, 2014
    Inventors: Julian Pardo Jimeno, Eva M. Galvez Buerba, M. Pilar Domingo Regidor
  • Publication number: 20140147925
    Abstract: The present invention provides a method for profiling phytohormone levels in plant tissue or tissue of other plastid containing organisms, i.e. a method for the simultaneous determination of a multitude of phytohormone levels in plant tissue or tissue of other plastid containing organisms, which method comprises the following steps: i. extraction of particulate tissue material of the plastid containing organism, in particulate tissue material of plants, with a liquid extractant, which is a mixture of at least one water miscible neutral organic solvent having from 1 to 3 carbon atoms and 1 heteroatom selected from O and N with water containing from 0.1 to 5% by weight, based on the extractant, of at least one acid, whereby a first liquid extract is obtained; ii. contacting the liquid extract obtained in step i. with a solid absorbent having a hydrophobically modified surface and removing the solid absorbent to obtain a second liquid extract; iii.
    Type: Application
    Filed: April 13, 2012
    Publication date: May 29, 2014
    Applicant: BASF PLANT SCIENCE COMPANY GMBH
    Inventors: Regine Fuchs, Martin Dostler, Maria Wahl, Benjamin Hentschel, Ralf Looser
  • Publication number: 20140127822
    Abstract: One aspect of the invention relates to an ultrathin micro-electromechanical chemical sensing device which uses swelling or straining of a reactive organic material for sensing. In certain embodiments, the device comprises a contact on-off switch chemical sensor. For example, the device can comprises a small gap separating two electrodes, wherein the gap can be closed as a result of the swelling or stressing of an organic polymer coating on one or both sides of the gap. In certain embodiments, the swelling or stressing is due to the organic polymer reacting with a target analyte.
    Type: Application
    Filed: May 14, 2013
    Publication date: May 8, 2014
    Applicant: Massachusetts Institute of Technology
    Inventors: William Jay Arora, Karen K. Gleason, George Barbastathis, Wyatt E. Tenhaeff
  • Publication number: 20140113379
    Abstract: An apparatus, system and method of detecting contaminants, such as melamine, in at least one ingestible item. The apparatus, system and method may include a disposable notched probe having therein at least one send and one receive fiber optic, or electrical, or heat source, and a reactant associated with said disposable notched probe, wherein a reaction of the reactant with at least a portion of the ingestible item indicates, to the consumer user, a presence of a contaminant.
    Type: Application
    Filed: October 17, 2013
    Publication date: April 24, 2014
    Inventors: Morton Greene, Edward M. Yokley
  • Publication number: 20140080163
    Abstract: A molecular probe for the luminescent detection of nucleotides (e.g., adenosine nucleotides) is presented. In certain embodiments, the probe can readily distinguish between the three adenosine nucleotides in buffered aqueous conditions at neutral pH, a need for the direct monitoring of enzymatic reactions converting ATP to ADP or AMP. The probe is most efficient under millimolar concentrations of ATP, which are relevant to intracellular conditions. In preferred embodiments, the long luminescence lifetime of the probe readily enables time-gating experiments.
    Type: Application
    Filed: September 10, 2013
    Publication date: March 20, 2014
    Inventor: Valerie Christine Pierre
  • Patent number: 8669258
    Abstract: Embodiments of the invention are directed to the treatment of gastroparesis by administering sepiapterin.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: March 11, 2014
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Pankaj J. Pasricha, Pandu R. R. Gangula
  • Publication number: 20140024127
    Abstract: The objects of embodiments in the present disclosure are to provide a method capable of recovering two or more amine compounds at the same time from a gas or solution, and also to provide a method capable of analyzing the recovered amines. The amine-recovering method comprises the steps (A) and (B). In the step (A), the gas or solution is brought into contact with a solid adsorbent so that the adsorbent may retain the amines. In the step (B), the amines retained by the adsorbent in the step (A) are eluted out by use of a basic compound-containing organic solvent. The solid adsorbent has a substituent group represented by —SO3M (M is H or an alkali metal).
    Type: Application
    Filed: July 16, 2013
    Publication date: January 23, 2014
    Applicant: KABUSHIKI KAISHA TOSHIBA
    Inventors: Hiroko WATANDO, Takashi Kuboki
  • Publication number: 20140011282
    Abstract: The present invention generally relates to a low temperature plasma probe for desorbing and ionizing at least one analyte in a sample material and methods of use thereof. In one embodiment, the invention generally relates to a low temperature plasma probe including: a housing having a discharge gas inlet port, a probe tip, two electrodes, and a dielectric barrier, in which the two electrodes are separated by the dielectric barrier, in which application of voltage from a power supply generates a low temperature plasma, and in which the low temperature plasma is propelled out of the discharge region by the electric field and/or the discharge gas flow.
    Type: Application
    Filed: August 26, 2013
    Publication date: January 9, 2014
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: Zheng Ouyang, Jason Harper, Nicholas Charipar, Robert Graham Cooks
  • Publication number: 20130330829
    Abstract: Systems and methods are provided for predicting the likelihood of acute kidney injury. An input interface is configured to receive a plurality of features derived from the results of a post-surgical metabolic blood panel and either a pre-surgical metabolic blood panel or a perisurgical metabolic blood panel. A predictive model is configured to calculate a parameter representing a likelihood of acute kidney injury from the plurality of features. A user interface is configured to provide the calculated parameter to a user in a human comprehensible form.
    Type: Application
    Filed: June 6, 2013
    Publication date: December 12, 2013
    Inventor: Sevag G. Demirjian
  • Publication number: 20130323728
    Abstract: The present invention relates to methods and kits for the detection of 5-hydroxymethylcytosme (5hmC). In some embodiments, the present invention relates to methods and kits for detection of 5hmC in nucleic acid (e.g., DNA, RNA). In some embodiments, the present invention relates to detection of 5hmC in genomic DNA, e.g., mammalian genomic DNA.
    Type: Application
    Filed: October 20, 2011
    Publication date: December 5, 2013
    Applicant: OSLO UNIVERSITETSSYKEHUS HF
    Inventors: Adam Brian Robertson, John Arne Dahl, Arne Klungland
  • Patent number: 8597956
    Abstract: An ultrasensitive method for detecting non-aromatic non-planar nitroamine analytes in a sample is provided.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: December 3, 2013
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Itamar Willner, Ran Tel-Vered, Michael Riskin
  • Publication number: 20130309775
    Abstract: It is a subject of the present invention to provide a novel polymer; a filler for measuring a perfluoro compound having an acidic group at terminal which comprises said polymer; a column filled with said filler; and a measuring method for a perfluoro compound having an acidic group at terminal by using said column; as well as a filler for measuring a drug comprising the above-described polymer; a column filled with said filler; and a measuring method for a drug by using said column.
    Type: Application
    Filed: July 24, 2013
    Publication date: November 21, 2013
    Applicants: Nippon Filcon Co., Ltd., Wako Pure Chemical Industries, Ltd.
    Inventors: Yoshinori Inoue, Kimiko Yoshida, Mamoru Kubota, Hitoshi Uemori
  • Patent number: 8574916
    Abstract: A method of detecting melamine which includes providing a quantity of SERS-active particles and mixing the SERS-active particles with a solution containing melamine. The method further includes detecting a surface enhanced Raman spectrum of the melamine. The foregoing method may optionally include aggregating the SERS-active particles. Aggregation may occur before or after the SERS-active particles are mixed with a solution containing melamine. The method of detecting melamine may optionally include concentration of the SERS-active particles. The method may further include mixing a chaotropic agent having a higher affinity for a selected binding site than melamine into the solution containing melamine. The method may further include mixing a quantity of a SERS-active standard having a known SERS spectrum with the solution containing melamine and SERS-active particles. Assay apparatus and systems are also disclosed.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: November 5, 2013
    Assignee: Cabot Security Materials Inc.
    Inventors: Michael J. Natan, Richard Griffith Freeman, William E. Doering, Rebecca Stoermer Golightly
  • Publication number: 20130280749
    Abstract: A FRET donor-acceptor pair for use as a biosensor, comprising at least two fluorescence proteins, wherein at least one fluorescence protein is stable with respect to a parameter to be detected by the biosensor and at least one fluorescence protein is unstable with respect to the parameter to be detected by the biosensor.
    Type: Application
    Filed: August 16, 2011
    Publication date: October 24, 2013
    Applicant: EVOCATAL GMBH
    Inventors: Karl Erich Jaeger, Thomas Drepper, Stephan Endres, Janko Potzkei, Achim Heck, Franco Circolone
  • Publication number: 20130244263
    Abstract: The invention is directed to a method of identifying a patient undergoing periodic hemodialysis treatments at increased risk for death that includes determining at least one of the patient's clinical or biochemical parameters, consisting of serum bicarbonate concentration level, serum potassium concentration level, serum calcium concentration level, hemoglobin concentration level, serum phosphorus concentration level, neutrophil to lymphocyte ratio, equilibrated normalized protein catabolic rate (enPCR), equilibrated fractional clearance of total body water by dialysis and residual kidney function (eKdrt/V), EPO resistance index, transferrin saturation index, serum ferritin concentration level, serum creatinine concentration level, platelet count, Aspartat-Aminotransferase level, and Alanin-Aminotransferase level at periodic hemodialysis treatments, and identifying a patient as having an increased risk for death if the patient has a significant change in the rate of change of at least one of the patient's cli
    Type: Application
    Filed: December 1, 2011
    Publication date: September 19, 2013
    Inventors: Peter Kotanko, Stephan Thijssen, Len Usvyat, Nathan W. Levin
  • Patent number: 8535946
    Abstract: The response of a patient with an enteropathic disease to therapy, particularly a candidate therapy in a clinical trial setting, is assessed by detecting the ability of the patient to metabolize an orally administered CYP3A substrate. The CYP3A metabolism may be monitored in a variety of ways. Conveniently, the appearance of a metabolite of the CYP3A substrate is detected in a patient sample over a period of time following oral administration, e.g. in urine, plasma, breath, saliva, etc. The CYP3A substrate is optionally labeled, e.g. with an isotopic, fluorescent, etc. label.
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: September 17, 2013
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chaitan Khosla, Michael Bethune
  • Publication number: 20130237543
    Abstract: The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample.
    Type: Application
    Filed: February 6, 2013
    Publication date: September 12, 2013
    Applicant: BIOMARIN PHARMACEUTICAL INC.
    Inventors: Daniel I. Oppenheimer, Alejandro Dorenbaum, Augustus O. Okhamafe, Erik Foehr, Sianna Castillo, Paul John Kostel
  • Publication number: 20130210159
    Abstract: A method for evaluating an odor generated when using a self-tanning agent, wherein at least one compound selected from pyrazine compounds represented by the following general formula (1) is used as an indicator substance: wherein R1 represents a methyl group, an ethyl group or an acetyl group, and R2, R3 and R4 independently represent a hydrogen atom or a methyl group.
    Type: Application
    Filed: February 7, 2013
    Publication date: August 15, 2013
    Applicant: Kao Corporation
    Inventors: Masayuki Yabuki, Miki Takahashi
  • Publication number: 20130171071
    Abstract: The present invention relates to imidazolium salts, particularly imidazolium salts of the general formula I as well as the respective carbene metal complexes and their utilisation as bioanalytical tags for biomolecules.
    Type: Application
    Filed: September 5, 2011
    Publication date: July 4, 2013
    Applicant: ERNST-MORITZ-ARNDT-UNIVERSITAT GREIFSWALD
    Inventor: Olaf Kuehl
  • Patent number: 8455265
    Abstract: A surface grafted conjugated polyelectrolyte (CPE) is formed by coupling a CPE by a coupling moiety to the surface of a substrate. The substrate can be of any shape and size, and for many uses of the surface grafted CPE, it is advantageous that the substrate is a nanoparticle or microparticle. Surface grafted CPEs are presented that use silica particles as the substrate, where a modified silane coupling agent connects the surface to the CPE by a series of covalent bonds. Two methods of preparing the surface grafted CPEs are presented. One method involves the inclusion of the surface being modified by the coupling agent and condensed with monomers that form the CPE in a grafted state to the substrate. A second method involves the formation of a CPE with terminal groups that are complimentary to functionality that has been placed on the surface of the substrate by reaction with a coupling agent. The surface grafted CPEs are also described for use as biosensors and biocides.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: June 4, 2013
    Assignee: STC.UNM
    Inventors: David G. Whitten, Sireesha Chemburu, Thomas Corbitt, Linnea Ista, Gabriel Lopez, Kirk S. Schanze, Motokatsu Ogawa, Eunkyung Ji
  • Publication number: 20130109046
    Abstract: The invention relates to methods for detecting the presence of a compound of formula I in a biological test sample: where R2, R3, and R4 are as defined in the specification; or a salt thereof.
    Type: Application
    Filed: December 17, 2012
    Publication date: May 2, 2013
    Applicant: THERAVANCE, INC.
    Inventors: Yuqin Dai, Donavon McConn, Huiyu Zhao
  • Patent number: 8426207
    Abstract: Devices, methods and systems effective to evaluate a physical or chemical property of an ion exchange resin-treated biological fluid sample are provided.
    Type: Grant
    Filed: May 20, 2009
    Date of Patent: April 23, 2013
    Assignee: Cantimer, Inc.
    Inventors: Ray F. Stewart, Aaron Dickerman-Stewart
  • Patent number: 8426213
    Abstract: The present invention relates to providing improved hydrogen peroxide assays, as well as droplet actuators for conducting such assays. The droplet actuators of the invention may be used to conduct droplet-based hydrogen peroxide assays. They may also be associated with detectors for analyzing the results of the hydrogen peroxide assays of the invention. They may be provided as components of systems which control droplet operations and/or detection for conducting the hydrogen peroxide assays. Measurement by the detector may be used to quantify the presence of an analyte in a sample.
    Type: Grant
    Filed: March 5, 2008
    Date of Patent: April 23, 2013
    Assignee: Advanced Liquid Logic Inc
    Inventors: Allen E. Eckhardt, Vijay Srinivasan, Vamsee K. Pamula
  • Publication number: 20130084644
    Abstract: A chemical sensor is disclosed. The chemical sensor is an electronic device including in specific embodiments a first transistor and a second transistor. The first transistor includes a semiconducting layer made of a first semiconductor and carbon nanotubes. The second transistor includes a semiconducting layer made of a second semiconductor, and does not contain carbon nanotubes. The two transistors vary in their response to chemical compounds, and the differing response can be used to determine the identity of certain chemical compounds. The chemical sensor can be useful as a disposable sensor for explosive compounds such as trinitrotoluene (TNT). The electronic device is used in conjunction with an analyzer that processes information generated by the electronic device.
    Type: Application
    Filed: October 4, 2011
    Publication date: April 4, 2013
    Applicant: XEROX CORPORATION
    Inventors: Yiliang Wu, Ping Liu, Anthony James Wigglesworth