Hetero-n Patents (Class 436/96)
  • Patent number: 10261017
    Abstract: Methods for detecting skin sensitization chemical compounds using Nuclear Magnetic Resonance (NMR) spectroscopy and/or a microplate spectrophotometric assay or other spectroscopic methods. The presently disclosed subject matter relates to a method of detecting skin sensitization potential of a test chemical compound using Nuclear Magnetic Resonance (NMR) spectroscopy, microplate spectrophotometry or other spectroscopic methods as stand-alone or in combination.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: April 16, 2019
    Assignee: University of Mississippi
    Inventors: Amar G. Chittiboyina, Ikhlas Ahmad Khan, Cristina Avonto
  • Patent number: 10184927
    Abstract: The invention provides a method for measuring the concentration of anionic polymers in an industrial water system. Specifically, the concentration of anionic polymer can be measured by combining an indicator dye composition that includes an acridine compound or a salt thereof to a water sample and measuring the absorbance of the mixture. The concentration can be determined by comparing the absorbance of the mixture to absorbance values on a pre-determined calibration curve. The dosage of anionic polymer can be optionally adjusted based on the concentration.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: January 22, 2019
    Assignee: Ecolab USA Inc.
    Inventor: Hua Zheng
  • Patent number: 10106403
    Abstract: A device is disclosed for detecting at least one chemical compound comprising at least one carbon nanotube with several graphene layers, on which is grafted at least one molecule bearing group G1 capable of reacting with the chemical compound or a precursor of such a group G1. The uses and the method of making such a device is also disclosed.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: October 23, 2018
    Assignee: Commissariat à l'énergie atomique et aux énergies alternatives
    Inventors: Martine Mayne-L'Hermite, Serge Palacin, Pascale Chenevier, Jér{hacek over (o)}me Chancolon, Aurélien Gohier
  • Patent number: 9234901
    Abstract: Provided are methods of detecting the presence or amount of the active form of vitamin B6, pyridoxal 5?-phosphate, in a body fluid sample using tandem mass spectrometry coupled with liquid chromatography.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: January 12, 2016
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Qibo Jiang, Sum Chan, Richard Reitz
  • Patent number: 9062014
    Abstract: The invention relates to crystalline forms of (R)-5-[3-chloro-4-(2,3-dihydroxy-propoxy)-benz[Z]ylidene]-2-([Z]-propylimino)-3-o-tolyl-thiazolidin-4-one, processes for the preparation thereof, pharmaceutical compositions containing said crystalline forms, and their use as compounds improving vascular function and as immunomodulating agents, either alone or in combination with other active compounds or therapies.
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: June 23, 2015
    Assignee: ACTELION PHARMACEUTICALS LTD.
    Inventors: Nicholas Bonham, Stephan Buchmann, Alex Eberlin, Christoph Imboden, Markus Von Raumer
  • Publication number: 20150132857
    Abstract: A device for detecting airborne contaminants includes a protonated, electrically conductive sensing material with affinity for binding with, and capable of being deprotonated by, the airborne contaminant. Electronics measure a property of the sensing material that is sensitive to deprotonation and generates signals indicative of the airborne contaminant. A method for detecting airborne contaminants includes: determining a property change of the protonated, electrically conductive material; and determining presence of the airborne contaminant based on the change.
    Type: Application
    Filed: June 13, 2013
    Publication date: May 14, 2015
    Inventors: Joseph J. Belbruno, Susanne E. Tanski
  • Patent number: 9018016
    Abstract: What is provided includes a porous sol-gel material whose intrinsic pH is lower than 1 and comprising at least one probe molecule chosen from the group consisting of croconic acid, p-dimethyl-aminobenzaldehyde (DMABA), p-dimethyl aminocinnamaldehyde (DMACA), p-methoxybenzaldehyde (MOB) and 4-methoxy-1-naphtaldehyde (MON). In addition, a detection system containing the porous sol-gel material and a method of preparation and use of the porous sol-gel material for trapping and/or detecting and optionally quantifying at least one chemical compound such as indole and indole compounds are provided.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: April 28, 2015
    Assignee: Commissariat a l'Energie Atomique et aux Energies Alternatives
    Inventors: Sabine Crunaire, Thu-Hoa Tran-Thi
  • Patent number: 9005986
    Abstract: A method for rapidly measuring melatonin adulteration of Chinese patent medicines and healthcare foods comprises: (1) extracting melatonin added to a Chinese patent medicine or healthcare food by using ethyl acetate; and (2) adding p-dimethylaminocinnamaldehyde to the extracted solution, and observing color. The method is rapid, simple and convenient, has strong specificity, high accuracy, reaction sensitivity, and a wide application range, and is applicable to on-site detection of melatonin adulteration of a Chinese patent medicine or healthcare food.
    Type: Grant
    Filed: July 2, 2012
    Date of Patent: April 14, 2015
    Assignee: Shenzhen Institute For Drug Control
    Inventors: Tiejie Wang, Yi Lu, Lihe Xiao, Xiaoying Guan, Dongqi Han, Guo Yin, Jue Wang, Xueqing Li, Yan Yan
  • Patent number: 9006459
    Abstract: Novel fluorescent markers of Formula I: are disclosed herein, wherein X and Y are independently or together absent or are independently selected from R and R1 are independently selected from H and alkyl; Ar is phenyl or heteroaryl; L is absent or a spacer selected from the group consisting of —NH—; —(CH2)nNH—; —NHSO2—; —(CH2)nNHCO—; -(cycloalkyl)NHCO—; —(CH2)nNHSO2—; -(cycloalkyl)NHSO2—; —CONH(CH2)nNHCO—; —CONH(cycloalkyl)NHCO—; —NHCO(CH2)nNHCO—; —NHCO(cycloalkyl)NHCO—; —(CH2)nSO2NH—; -(cycloalkyl)SO2NH—; —(CH2)nNHCSNH—; -(cycloalkyl)NHCSNH—; —CR?CR1—; —C?C—; —(CH2)nN?CH—; -(cycloalkyl)N?CH—; —N?CH(CH2)—; —N?CH(cycloalkyl)-; n is an integer ranging from 1 to 5; F is a fluorophore selected from the group consisting of fluorescein, rhodamine, eosin, thionine, safranin, coumarin, methoxycoumarin, dansyl, BODIPY and BODIPY derivatives; and wherein X, Y and L may be positioned in a 1,3,5; 1,2,3; 1,3,4 or in a 3,4,5 configuration respectively.
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: April 14, 2015
    Assignee: University of Ottawa
    Inventors: Jeffrey Keillor, Karine Caron
  • Patent number: 8986998
    Abstract: Disclosed herein is a method for identifying the compounds contributing to a pungent odor from an air conditioner, a method for artificially reproducing the pungent odor, and preparing a corresponding pungent odor composition. Through the analysis method of the present invention, the compounds contributing to the pungent odor from an air conditioner may be identified and quantified. The pungent odor may be reproduced from a combination of the compounds identified by the analysis method of the present invention. The reproduced pungent odor may provide significant data required for development of an apparatus and a method for removing specific odors.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: March 24, 2015
    Assignee: Hyundai Motor Company
    Inventors: Tae Hee Lee, Ji Wan Kim
  • Patent number: 8975014
    Abstract: The invention herein disclosed provides for compositions, methods for synthesizing said compositions, and methods for using said compositions, wherein the compositions and methods may be used to bind to and/or deactivate a poison oak oil, such as urushiol. The compositions and methods can be used to treat and/or reduce an inflammatory reaction and/or hypersensitivity to natural compounds found in poison oak, poison ivy, poison sumac, mango, lac tree, and cashew nut.
    Type: Grant
    Filed: May 6, 2014
    Date of Patent: March 10, 2015
    Assignee: The Regents of the University of California
    Inventor: Rebecca Braslau
  • Patent number: 8956876
    Abstract: There is provided a method for quantitatively detecting 8-oxo 2?-deoxyguanosine in an aqueous sample solution with high sensitivity. A method for quantitatively detecting 8-oxo 2?-deoxyguanosine in an aqueous sample solution, including the steps of 1) immobilizing a fluorescent probe molecule showing a fluorescence response specific to 8-oxo 2?-deoxyguanosine on surfaces of fine particles via a spacer unit and bringing the sample solution into contact with the fine particles, and 2) measuring a physical property of the fine particles before and after the contact with the sample solution to determine a change in the physical property.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: February 17, 2015
    Assignee: TAS Project Co. Ltd
    Inventors: Shigeki Sasaki, Osamu Nakagawa, Zhichun Li, Atsushi Takaki, Sachiyo Saitoh
  • Patent number: 8949038
    Abstract: Described herein is a method of controlling bitumen quality in a process stream within a solvent-assisted bitumen extraction operation, for instance a hydrocarbon stream from a froth separation unit (FSU). Bitumen quality is a measure of the amount of selected contaminants in the process stream. Contaminants may include asphaltenes (comprising metal porphyrins), sulfur, and inorganic solids (comprising inorganic elements, e.g. Si, Al, Ti, Fe, Na, K, Mg, and Ca). First, the amounts of selected contaminants are measured. Next, these measured values are compared to maximum reference values. If one or more of these contaminants is higher than the maximum reference value, at least one variable of the solvent-assisted bitumen extraction is adjusted to improve bitumen quality.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: February 3, 2015
    Assignee: ExxonMobil Upstream Research Company
    Inventors: Tapantosh Chakrabarty, Ken N. Sury, Joseph L. Feimer
  • Publication number: 20150031572
    Abstract: The present invention pertains to the field of diagnostics for neuronal toxicity and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing neuronal toxicity. It also relates to a method for determining whether a compound is capable of inducing such neuronal toxicity in a subject and to a method of identifying a drug for treating neuronal toxicity. Furthermore, the present invention relates to a device and a kit for diagnosing neuronal toxicity.
    Type: Application
    Filed: February 15, 2013
    Publication date: January 29, 2015
    Applicant: BASF SE
    Inventors: Tilmann B. Walk, Bennard van Ravenzwaay, Werner Mellert, Eric Fabian, Volker Strauss, Hennicke Kamp, Jan C. Wiemer, Ralf Looser, Michael Manfred Herold, Alexandre Prokoudine
  • Publication number: 20150017732
    Abstract: A colorimetric assay to detect certain compounds and a kit therefore are provided.
    Type: Application
    Filed: July 11, 2014
    Publication date: January 15, 2015
    Inventors: Tsunghsueh Wu, Charles Cornett
  • Patent number: 8871520
    Abstract: The invention provides a method of detecting uracil. The method comprises reacting uracil with a compound represented by the formula (I) in the presence of an oxidant and a base to produce a fluorescent compound represented by the formula (II).
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: October 28, 2014
    Assignee: Nagasaki University
    Inventors: Masaaki Kai, Takayuki Shibata
  • Publication number: 20140315972
    Abstract: The invention relates to a compound (RS)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide having modulatory activity with a commensurate effect, to a pharmaceutical substance (RS)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide containing: 2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide—no less than 99.0% and no more than 100.5% on dry basis, individual related impurities individually or in total—no more than 0.2%; residual amounts of organic solvents individually or in total—no more than 3000 ppm. The invention also relates to a method for producing the pharmaceutical substance differing in that the obtained raw materials are subjected to purification, crystallization and stabilization of the compound by processing it with demineralized (distilled) water, and the isothermal crystallization from propanol followed by drying. The invention also relates to compositions for internal and external application. The invention provides higher efficacy, safety, stability and width of therapeutic application.
    Type: Application
    Filed: September 20, 2012
    Publication date: October 23, 2014
    Inventors: Valentina Ivanovna Akhapkina, Roman Vitalyevich Akhapkin
  • Patent number: 8865077
    Abstract: An apparatus for detecting an object capable of emitting light. The apparatus comprises a light source and a waveguide. The waveguide comprises a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further comprises a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: October 21, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
  • Patent number: 8865078
    Abstract: An apparatus for detecting an object capable of emitting light. The apparatus includes a light source and a waveguide. The waveguide includes a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further includes a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
    Type: Grant
    Filed: July 29, 2010
    Date of Patent: October 21, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
  • Publication number: 20140309258
    Abstract: Compositions comprising isolated ido-BR1 are described for use in therapy or prophylaxis, including the treatment of inflammatory diseases (for example as anti-inflammatory drugs) and to reduce inflammation. Also described are methods for monitoring the quality of a Cucurbitaceae extract, to processes for producing a Cucurbitaceae extract as well as to Cucurbitaceae extracts obtainable by such processes.
    Type: Application
    Filed: April 11, 2014
    Publication date: October 16, 2014
    Applicant: Phytoquest Limited
    Inventor: Robert James Nash
  • Patent number: 8809063
    Abstract: A fluorescence based sensor (10) is disclosed and described. The sensor (10) can include nanofibril materials (12) fabricated from a linear carbazole oligomer and a fluorescence detector (14). The linear carbazole oligomer can have the formula (I) wherein n is 3 to 9, R are independently selected amine sidegroups, and at least one, but not all, R is a C1 to C14 alkyl. The carbazole-based fluorescence based sensors (10) can be particularly suitable for detection of explosives and volatile nitro compounds.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: August 19, 2014
    Assignee: University of Utah Research Foundation
    Inventors: Ling Zang, Yanke Che
  • Publication number: 20140220698
    Abstract: A method for rapidly measuring melatonin adulteration of Chinese patent medicines and healthcare foods comprises: (1) extracting melatonin added to a Chinese patent medicine or healthcare food by using ethyl acetate; and (2) adding p-dimethylaminocinnamaldehyde to the extracted solution, and observing color. The method is rapid, simple and convenient, has strong specificity, high accuracy, reaction sensitivity, and a wide application range, and is applicable to on-site detection of melatonin adulteration of a Chinese patent medicine or healthcare food.
    Type: Application
    Filed: July 2, 2012
    Publication date: August 7, 2014
    Inventors: Tiejie Wang, Yi Lu, Lihe Xiao, Xiaoying Guan, Dongqi Han, Guo Yin, Jue Wang, Xueqing Li, Yan Yan
  • Patent number: 8785205
    Abstract: The present invention relates to assays for detection of nicotine metabolites, in particular cotinine, in fluid samples and uses of these assays in quantification of smoking habits. The assays comprise contacting a body fluid sample with a cyanogen halide and a pyrazolone compound and detecting a change in light absorbance of the pyrazolone compound which is associated with the presence of nicotine metabolites. Also provided are assay kits including a cyanogen halide or cyanogen halide-precursor(s) and a pyrazolone compound.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: July 22, 2014
    Assignee: GFC Diagnostics Ltd.
    Inventors: Charles John Knill, John Frederick Kennedy
  • Patent number: 8785204
    Abstract: The invention provides a method of assaying for tetrahydrocannabinol in a body fluid. The method includes contacting a sample of body fluid with an imine capable of reacting with tetrahydrocannabinol to yield a quinone imine, and detecting the formation of a quinone imine, where the sample is contacted with the reagent compound at a pH of at least 10.5.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: July 22, 2014
    Assignee: Oxtox Limited
    Inventors: Dimitrios Konstantinos Kampouris, Patrick Robinson Huddleston, Craig Edward Banks
  • Publication number: 20140186873
    Abstract: Disclosed herein are isotopically labeled antifungal antibiotics and related compounds. Also disclosed are methods for synthesizing these isotopically labeled molecules and using the same to study the distribution of these compounds in the biosphere as well as the products formed by the breakdown of these isotopically labeled compounds.
    Type: Application
    Filed: December 23, 2013
    Publication date: July 3, 2014
    Inventors: Ronald Ross, Jr., Peter Lee Johnson, Kevin G. Meyer
  • Publication number: 20140147925
    Abstract: The present invention provides a method for profiling phytohormone levels in plant tissue or tissue of other plastid containing organisms, i.e. a method for the simultaneous determination of a multitude of phytohormone levels in plant tissue or tissue of other plastid containing organisms, which method comprises the following steps: i. extraction of particulate tissue material of the plastid containing organism, in particulate tissue material of plants, with a liquid extractant, which is a mixture of at least one water miscible neutral organic solvent having from 1 to 3 carbon atoms and 1 heteroatom selected from O and N with water containing from 0.1 to 5% by weight, based on the extractant, of at least one acid, whereby a first liquid extract is obtained; ii. contacting the liquid extract obtained in step i. with a solid absorbent having a hydrophobically modified surface and removing the solid absorbent to obtain a second liquid extract; iii.
    Type: Application
    Filed: April 13, 2012
    Publication date: May 29, 2014
    Applicant: BASF PLANT SCIENCE COMPANY GMBH
    Inventors: Regine Fuchs, Martin Dostler, Maria Wahl, Benjamin Hentschel, Ralf Looser
  • Patent number: 8735057
    Abstract: The invention herein disclosed provides for compositions, methods for synthesizing said compositions, and methods for using said compositions, wherein the compositions and methods may be used to bind to and/or deactivate a poison oak oil, such as urushiol. The compositions and methods can be used to treat and/or reduce an inflammatory reaction and/or hypersensitivity to natural compounds found in poison oak, poison ivy, poison sumac, mango, lac tree, and cashew nut.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: May 27, 2014
    Assignee: The Regents of the University of California
    Inventor: Rebecca Braslau
  • Publication number: 20140134105
    Abstract: The present invention relates to a composition and method for the detection of a detectable product formed from a compound of the present invention in the body of an individual. The detectable product may include a halide or a benzenetriol-based or benzenetetrol-based product of a dehalogenation reaction in the presence of FROS. In many embodiments, an indigo-like product formed from an indigogenic compound of the present invention may also be a detectable product for diagnostic purposes. This indigo-like product may have a higher residence time in tissues where it is formed, thus providing a detectable product localized to sites of high FROS. An indigogenic compound containing one or more radioactive isotopes is further provided for therapeutic purposes.
    Type: Application
    Filed: January 16, 2014
    Publication date: May 15, 2014
    Inventor: Keith R. Latham
  • Patent number: 8721969
    Abstract: An apparatus for detecting an object capable of emitting light. The apparatus comprises a light source and a waveguide. The waveguide comprises a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further comprises a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: May 13, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
  • Patent number: 8703498
    Abstract: A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: April 22, 2014
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Ian Christopher Parsons, Ting Zheng, Nur Sibel Gunay, Carlos J. Bosques
  • Patent number: 8703500
    Abstract: A chemical sensor can include a nanofiber mass of p-type nanofibers having a HOMO level greater than ?5.0 eV. Additionally, the chemical sensor can include oxygen in contact with the p-type nanofibers. Further, the chemical sensor can include a pair of electrodes in electrical contact across the nanofiber mass, where the p-type nanofibers conduct an electric current that decreases upon contact with an amine compound.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: April 22, 2014
    Assignee: University of Utah Research Foundation
    Inventors: Ling Zang, Yanke Che
  • Publication number: 20140093887
    Abstract: The present invention provides a method of detecting (e.g., by flow cytometry) a target compound, cell or particle, wherein the target is labelled with a detectable luminescent compound. The method comprises utilizing as the detectable luminescent compound a compound comprising a porphyrinic macrocycle such as a porphyrin, chlorin, bacteriochlorin, or isobacteriochlorin. In particular embodiments, the detectable luminescent compound comprises a compound of the formula A-A?-Z-B?-B, wherein: A is a targeting group or member of a specific binding pair that specifically binds the detectable luminescent compound to the target compound, cell or particle; A? is a linker group or covalent bond; B? is a linker group or covalent bond; B is a water-soluble group; and Z is the porphyrinic macrocycle.
    Type: Application
    Filed: August 29, 2013
    Publication date: April 3, 2014
    Applicant: North Carolina State University
    Inventor: Jonathan S. Lindsey
  • Patent number: 8685739
    Abstract: There is provided a method of diagnosing a disease state in a subject. The disease state is caused or effected by pneumococcal infection. The method includes obtaining a biological test sample from the subject. The biological sample includes at least one metabolite selected from the group consisting of citrate, trigonelline, acetylcarnitine, acetone, myo-inositol, 3-hydroxybutyrate, glucose and carnitine. A respective concentration of each one of the at least one metabolite is compared with a predetermined concentration value associated with a corresponding one of the at least one metabolite. The predetermined concentration value is indicative of the disease state. For example, the biological sample includes any one of citrate, trigonelline, acetylcamitine, acetone, myoinositol, 3-hydroxybutyrate, glucose and carnitine. As a further example, the biological samples include any combination of citrate, trigonelline, acetylcamitine, acetone, myo-inositol, 3-hydroxybutyrate, glucose and carnitine.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: April 1, 2014
    Inventors: Carolyn Slupsky, Thomas Marrie
  • Patent number: 8658795
    Abstract: Novel pyridinium salts functionalized with boronic acid and methods of making them are disclosed. When combined with a fluorescent dye, the compounds are useful in the detection of polyhydroxyl-substituted organic molecules.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: February 25, 2014
    Assignee: Glumetrics, Inc.
    Inventors: Soya Gamsey, Ritchie A. Wessling
  • Publication number: 20140024678
    Abstract: The subject invention provides a pharmaceutical composition comprising N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5- chloro-1-methyl-2-oxoquinoline-3-carboxamide or the salt thereof; a pharmaceutically acceptable carrier; and not more than 0.5% w/w relative to N-ethyl-N-phenyl-1,2,-dihydro-4 -hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide of 2-Chloro-6-(1-ethyl-N-methyl-2-oxoindoline-3-carboxamido) benzoic acid, 1H,3H-spiro[5-chloro-1-methylquinoline-2,4 -dione-3,3?-[1]ethylindolin-[2]-one], or 5-Chloro-N-ethyl-3-hydroxy-1-methyl-2,4-dioxo-N-phenyl-1,2,3,4 -tetrahydro-quinoline-3-carboxamide.
    Type: Application
    Filed: September 20, 2013
    Publication date: January 23, 2014
    Applicant: TEVA PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Muhammad Safadi, Daniella Licht, Ioana Lovinger, Aharon M. Eyal, Tomas Fristedt, Karl Jansson
  • Publication number: 20140011282
    Abstract: The present invention generally relates to a low temperature plasma probe for desorbing and ionizing at least one analyte in a sample material and methods of use thereof. In one embodiment, the invention generally relates to a low temperature plasma probe including: a housing having a discharge gas inlet port, a probe tip, two electrodes, and a dielectric barrier, in which the two electrodes are separated by the dielectric barrier, in which application of voltage from a power supply generates a low temperature plasma, and in which the low temperature plasma is propelled out of the discharge region by the electric field and/or the discharge gas flow.
    Type: Application
    Filed: August 26, 2013
    Publication date: January 9, 2014
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: Zheng Ouyang, Jason Harper, Nicholas Charipar, Robert Graham Cooks
  • Patent number: 8597577
    Abstract: An optoelectronic swept-frequency semiconductor laser coupled to a microfabricated optical biomolecular sensor with integrated resonator and waveguide and methods related thereto are described. Biomolecular sensors with optical resonator microfabricated with integrated waveguide operation can be in a microfluidic flow cell.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: December 3, 2013
    Assignee: California Institute of Technology
    Inventors: Richard C. Flagan, Amnon Yariv, Jason Gamba, Naresh Satyan, Jacob Sendowski, Arseny Vasilyev
  • Patent number: 8597956
    Abstract: An ultrasensitive method for detecting non-aromatic non-planar nitroamine analytes in a sample is provided.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: December 3, 2013
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Itamar Willner, Ran Tel-Vered, Michael Riskin
  • Publication number: 20130309775
    Abstract: It is a subject of the present invention to provide a novel polymer; a filler for measuring a perfluoro compound having an acidic group at terminal which comprises said polymer; a column filled with said filler; and a measuring method for a perfluoro compound having an acidic group at terminal by using said column; as well as a filler for measuring a drug comprising the above-described polymer; a column filled with said filler; and a measuring method for a drug by using said column.
    Type: Application
    Filed: July 24, 2013
    Publication date: November 21, 2013
    Applicants: Nippon Filcon Co., Ltd., Wako Pure Chemical Industries, Ltd.
    Inventors: Yoshinori Inoue, Kimiko Yoshida, Mamoru Kubota, Hitoshi Uemori
  • Patent number: 8574916
    Abstract: A method of detecting melamine which includes providing a quantity of SERS-active particles and mixing the SERS-active particles with a solution containing melamine. The method further includes detecting a surface enhanced Raman spectrum of the melamine. The foregoing method may optionally include aggregating the SERS-active particles. Aggregation may occur before or after the SERS-active particles are mixed with a solution containing melamine. The method of detecting melamine may optionally include concentration of the SERS-active particles. The method may further include mixing a chaotropic agent having a higher affinity for a selected binding site than melamine into the solution containing melamine. The method may further include mixing a quantity of a SERS-active standard having a known SERS spectrum with the solution containing melamine and SERS-active particles. Assay apparatus and systems are also disclosed.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: November 5, 2013
    Assignee: Cabot Security Materials Inc.
    Inventors: Michael J. Natan, Richard Griffith Freeman, William E. Doering, Rebecca Stoermer Golightly
  • Patent number: 8574921
    Abstract: Provided is an optical sensing membrane, including a mixture of two or more fluorescent dyes for detection of dissolved oxygen concentration, pH and temperature, immobilized on a support, a detection device including the optical sensing membrane and a detection method using the detection device.
    Type: Grant
    Filed: April 29, 2009
    Date of Patent: November 5, 2013
    Assignee: Industry Foundation of Chonnam National University
    Inventors: Jong Il Rhee, Chun-Kwang Kim, Ok-Jae Sohn
  • Publication number: 20130281313
    Abstract: The present invention relates to the fields of genetics, immunology and medicine. The present invention more specifically relates to the identification of human genes and expression products thereof which can be used to assess the prognosis of a cancer in a subject, to assess the sensitivity of a subject to a treatment of cancer, or monitor, in particular determine the efficacy, of such a treatment of cancer after a given period of time. Said human genes and expression products can further be used (i) in the prevention or treatment of cancer, in particular to determine or select the appropriate cancer treatment for a given subject and/or for a particular tumor, as well as (ii) for the screening of therapeutically active drugs.
    Type: Application
    Filed: September 1, 2011
    Publication date: October 24, 2013
    Applicant: INSTITUT GUSTAVE ROUSSY
    Inventors: Lorenzo Galluzzi, Annick Harel-Bellan, Guido Kroemer, Ken Olaussen, Jean-Charles Soria
  • Patent number: 8563253
    Abstract: The present invention relates to a method for diagnosing hemolytic anemia or a predisposition thereof. It also relates to a method of determining whether a compound is capable of inducing hemolytic anemia in a subject and to a method of identifying a drug for treating hemolytic anemia. Furthermore, the present invention relates to a data collection comprising characteristic values of metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing hemolytic anemia. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing hemolytic anemia in a subject.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: October 22, 2013
    Assignee: Metanomics GmbH
    Inventors: Tilmann B. Walk, Ralf Looser, Michael Manfred Herold, Jan C. Wiemer, Alexandre Prokoudine, Edgar Leibold, Bennard van Ravenzwaay, Werner Mellert, Georgia Coelho Palermo Cunha, Eric Fabian, Volker Strauss
  • Publication number: 20130273586
    Abstract: The present invention relates to methods of diagnosing, monitoring, and treating elastin fiber injuries. In additional preferred embodiments, the present invention relates to methods of validating candidate compounds for use in treating chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, refractory asthma, and other related diseases. Examples of such methods include determining if the candidate compound decreases the degradation of elastic fiber in a patient administered the candidate compound by measuring, using mass spectrometry employing an internal standard, a marker of elastic fiber degradation in a sample of a body fluid or a tissue of the patient. The invention provides that a decrease in the presence of the marker compared to a control validates that the candidate compound is effective to treat, prevent, or ameliorate the disease.
    Type: Application
    Filed: March 15, 2013
    Publication date: October 17, 2013
    Inventors: Gerard M. TURINO, Shuren Ma, Yong Y. Lin, Seymour Leiberman
  • Patent number: 8545885
    Abstract: The subject invention provides a pharmaceutical composition comprising N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide or the salt thereof; a pharmaceutically acceptable carrier; and not more than 0.5% w/w relative to N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide of 2-Chloro-6-(1-ethyl-N-methyl-2-oxoindoline-3-carboxamido)benzoic acid, 1H,3H-spiro[5-chloro-1-methylquinoline-2,4-dione-3,3?-[1]ethylindolin-[2]-one], or 5-Chloro-N-ethyl-3-hydroxy-1-methyl-2,4-dioxo-N-phenyl-1,2,3,4-tetrahydro-quinoline-3-carboxamide.
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: October 1, 2013
    Assignees: Teva Pharmaceutical Industries, Ltd., Active Biotech, AB
    Inventors: Muhammad Safadi, Daniella Licht, Ioana Lovinger, Aharon M. Eyal, Tomas Fristedt, Karl Jansson
  • Patent number: 8541239
    Abstract: The invention provides an assay method for the detection of a primary amine analyze in an aqueous body fluid, which method comprises contacting a sample of said body fluid at a pH below 9.5 with a thiol and an unsaturated cis-dialdehyde and testing for the presence of a pyrrole reaction product.
    Type: Grant
    Filed: October 15, 2009
    Date of Patent: September 24, 2013
    Assignee: Oxtox Limited
    Inventors: Dimitrios Konstantinos Kampouris, Patrick Robinson Huddleston, Craig Edward Banks
  • Patent number: 8541240
    Abstract: The present invention generally relates to fluoride receptor reagent compounds that are derived from one or more N-aryl or heteroaryl substituted 1,4,5,8-naphthalenetetracarboxydiimide (NDI) units. The invention also relates to associated methods for the detection of fluoride in a composition. ?-electron orbitals present in the NDI unit of the reagents form a complex with fluoride anions. It is believed that the anion-? interaction results in a charge transfer process between the fluoride anion and the NDI unit, resulting in a number of measurable effects (e.g., colorimetric response).
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: September 24, 2013
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Sourav Saha, Samit Guha
  • Patent number: 8535946
    Abstract: The response of a patient with an enteropathic disease to therapy, particularly a candidate therapy in a clinical trial setting, is assessed by detecting the ability of the patient to metabolize an orally administered CYP3A substrate. The CYP3A metabolism may be monitored in a variety of ways. Conveniently, the appearance of a metabolite of the CYP3A substrate is detected in a patient sample over a period of time following oral administration, e.g. in urine, plasma, breath, saliva, etc. The CYP3A substrate is optionally labeled, e.g. with an isotopic, fluorescent, etc. label.
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: September 17, 2013
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Chaitan Khosla, Michael Bethune
  • Patent number: 8481324
    Abstract: The present invention provides a system containing an array of chemically sensitive sensors based on coated single walled carbon nanotubes, for measuring volatile organic compounds indicative of renal failure. Methods of breath analysis for diagnosing chronic, acute and end-stage renal failure are disclosed.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: July 9, 2013
    Assignee: Technion Research and Development Foundation Ltd.
    Inventors: Hossam Haick, Zaid Abassi, Farid Nakhoul
  • Patent number: 8455265
    Abstract: A surface grafted conjugated polyelectrolyte (CPE) is formed by coupling a CPE by a coupling moiety to the surface of a substrate. The substrate can be of any shape and size, and for many uses of the surface grafted CPE, it is advantageous that the substrate is a nanoparticle or microparticle. Surface grafted CPEs are presented that use silica particles as the substrate, where a modified silane coupling agent connects the surface to the CPE by a series of covalent bonds. Two methods of preparing the surface grafted CPEs are presented. One method involves the inclusion of the surface being modified by the coupling agent and condensed with monomers that form the CPE in a grafted state to the substrate. A second method involves the formation of a CPE with terminal groups that are complimentary to functionality that has been placed on the surface of the substrate by reaction with a coupling agent. The surface grafted CPEs are also described for use as biosensors and biocides.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: June 4, 2013
    Assignee: STC.UNM
    Inventors: David G. Whitten, Sireesha Chemburu, Thomas Corbitt, Linnea Ista, Gabriel Lopez, Kirk S. Schanze, Motokatsu Ogawa, Eunkyung Ji