Abstract: Systems, methods, and devices are provided for assessing DNA damage and repair in cells by measuring DNA migration under electrophoresis. In one exemplary embodiment, a microarray configured to hold cells in a predetermined spatial relationship is employed to improve accuracy, speed, and reliability of such measurements. In another embodiment, a self-contained cassette having a matrix material disposed therein can be used to create a substantially uniform environment for analyzing DNA damage and repair. Fluid can be circulated through the cell to assist in creating spatial patterns on the matrix material, or alternatively, the matrix material can already include a microarray pattern disposed thereon. Various methods and systems that take advantage of such microarrays and cassettes are also provided.
Type:
Grant
Filed:
July 12, 2012
Date of Patent:
November 24, 2015
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventors:
Sangeeta N. Bhatia, Bevin P. Engelward, David K. Wood, David M. Weingeist
Abstract: The present disclosure provides a method for determining the relative conformations of a protein provided in different protein preparations, comprising steps of: (i) obtaining a first 2D NOESY NMR spectrum of a first protein preparation; (ii) obtaining a second 2D NOESY NMR spectrum of a second protein preparation; and (iii); determining whether a protein has a different conformation in the first and second protein preparations by comparing one or more cross-peaks in the first 2D NOESY NMR spectrum with one or more corresponding cross-peaks in the second 2D NOESY NMR spectrum.
Type:
Grant
Filed:
April 15, 2008
Date of Patent:
November 10, 2015
Assignee:
Momenta Pharmaceuticals, Inc.
Inventors:
Ian Christopher Parsons, Jonathan Lansing, Carlos J. Bosques, Daniela Beccati
Abstract: In one embodiment, a chemical sensor is described. The chemical sensor includes a chemically-sensitive field effect transistor including a floating gate conductor having an upper surface. A material defines an opening extending to the upper surface of the floating gate conductor. The material comprises a first dielectric underlying a second dielectric. A conductive element contacts the upper surface of the floating gate conductor and extends a distance along a sidewall of the opening, the distance defined by a thickness of the first dielectric.
Type:
Grant
Filed:
March 5, 2014
Date of Patent:
September 8, 2015
Assignee:
Life Technologies Corporation
Inventors:
Keith G. Fife, Jordan Owens, Shifeng Li, James Bustillo
Abstract: In one embodiment, a chemical sensor is described. The chemical sensor includes a chemically-sensitive field effect transistor including a floating gate conductor. A material defines an opening overlying the floating gate conductor. The material comprises a conductive element having an inner surface defining a lower portion of a sidewall of the opening. A dielectric is on the conductive element and has an inner surface defining an upper portion of the sidewall.
Type:
Grant
Filed:
March 5, 2014
Date of Patent:
August 25, 2015
Assignee:
Life Technologies Corporation
Inventors:
Keith G. Fife, Jordan Owens, Shifeng Li, James Bustillo
Abstract: Microfluidic devices and methods of forming cell reactors for performing cell analysis in a microfluidic chip. A microfluidic chip, in one implementation, includes a plurality of trapping sites, each of the plurality of trapping sites having a plurality of micropillars configured to trap one or more cells in an interior space formed by the plurality of micropillars. The plurality of micropillars in each trapping site form a picoreactor for cell and molecular diagnostics, such as characterizing, isolation, processing, and amplification of different cells, cells containing different substances, different particles, different biochemical compositions, proteins, and enzymes.
Abstract: The present invention provides a method for producing a desired protein (such as a desired heterologous protein) comprising: (a) providing a host cell comprising a first recombinant gene encoding a protein comprising the sequence of a first chaperone protein, a second recombinant gene encoding a protein comprising the sequence of a second chaperone protein and a third gene, such as a third recombinant gene, encoding a desired protein (such as a desired heterologous protein), wherein the first and second chaperones are different; and (b) culturing the host cell in a culture medium to obtain expression of the first, second and third genes.
Type:
Grant
Filed:
December 23, 2005
Date of Patent:
June 16, 2015
Assignee:
NOVOZYMES BIOPHARMA DK A/S
Inventors:
Christopher John Arthur Finnis, Darrell Sleep, Gillian Shuttleworth
Abstract: The invention provides a method of redistributing magnetically responsive beads in a droplet. The method may include conducting on a droplet operations surface one or more droplet operations using the droplet without removing the magnetically responsive beads from the region of the magnetic field. The droplet operations may in some cases be electrode-mediated. The droplet operations may redistribute and/or circulate the magnetically responsive beads within the droplet. In some cases, the droplet may include a sample droplet may include a target analyte. The redistributing of the magnetically responsive beads may cause target analyte to bind to the magnetically responsive beads. In some cases, the droplet may include unbound substances in a wash buffer. The redistributing of the magnetically responsive beads causes unbound substances to be freed from interstices of an aggregated set or subset of the magnetically responsive beads.
Type:
Grant
Filed:
September 19, 2014
Date of Patent:
June 9, 2015
Assignee:
ADVANCED LIQUID LOGIC, INC.
Inventors:
Vamsee K. Pamula, Arjun Sudarsan, Ramakrishna Sista
Abstract: The present invention relates to the use of matrix metalloproteinase-2 (MMP2) as a predictive biomarker of response to antiangiogenic therapy and survival after antiangiogenic therapy in cancer patients, and to related methods for predicting or monitoring the response to an antiangiogenic treatment and the survival after said treatment of a cancer patient.
Abstract: The present invention relates to methods and compositions utilizing inteins to generate libraries of cyclic peptides in vivo. The prevent invention also relates to methods for inhibiting protein-protein interaction.
Type:
Grant
Filed:
May 12, 2008
Date of Patent:
May 26, 2015
Assignee:
Rigel Pharmaceuticals, Inc.
Inventors:
James B. Lorens, Todd R. Pray, Todd M. Kinsella, Mark K. Bennett
Abstract: Methods, compositions and arrays for non-random loading of single analyte molecules into array structures are provided. For example, methods are presented for providing a surface comprising the plurality of array regions by exposing the surface to a solution comprising polymerase enzymes where each polymerase enzyme is bound to a binding structure having several functional moieties. The functional moieties of the binding structure react with the binding elements on the array regions such that the functional moieties on the binding structure react with other available binding sites in an array region, preventing other polymerase-binding structures from loading, and resulting in a single polymerase molecule bound to each of these regions.
Type:
Application
Filed:
November 4, 2014
Publication date:
May 21, 2015
Inventors:
Stephen Turner, Benjamin Flusberg, Lei Sun
Abstract: The present invention concerns embodiments for determining whether an individual in need of immunotherapy will be responsive to the immunotherapy. Determination of one or more SNPs in particular genes is predictive of responsiveness to immunotherapy, particularly in individuals that have melanoma, for example. In certain embodiments, the SNPs are in ITGB2, SP1 1O, ILIB, IL23R, SLC11A1, IL12B, CCR5, TNF, ILIO, CXCL12, BTNL2, ANKRD20A4, CD 14, P2X7, IL8, TLR2, and/or CD209.
Type:
Application
Filed:
May 16, 2013
Publication date:
May 21, 2015
Inventors:
Dave S.B. Hoon, Donald L. Morton, Connie G. Chiu, Kelly Chong
Abstract: A method of determining a probability that a human test subject has colorectal cancer as opposed to not having colorectal cancer is disclosed.
Abstract: Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.
Type:
Grant
Filed:
February 26, 2010
Date of Patent:
May 19, 2015
Assignee:
CAPROTEC BIOANALYTICS GMBH
Inventors:
Hubert Köster, Daniel Paul Little, Suhaib Mahmood Siddiqi, Matthew Peter Grealish, Subramanian Marappan, Chester Frederick Hassman, III, Ping Yip
Abstract: An analytical method aided with a nucleic acid microarray, the nucleic acid microarray having a spot (X 1) onto which a first probe nucleic acid is immobilized, the method includes: allowing a labeled sample nucleic acid (A 1) of a sample to be tested to hybridize with the first probe nucleic acid; providing the spot (X 1) with a labeled verification nucleic acid (B) that has a sequence capable of hybridizing with at least a part of the first probe nucleic acid and is labeled with a label different from the labeled sample nucleic acid (A 1), and allowing the labeled verification nucleic acid (B) to hybridize with at least the first probe nucleic acid at all spots; measuring a labeled quantity value (F 1) of the labeled sample nucleic acid (A 1); and measuring a labeled quantity value (Fc 1) of the labeled verification nucleic acid (B).
Type:
Grant
Filed:
May 27, 2009
Date of Patent:
May 19, 2015
Assignees:
FUJIFILM Corporation, National University Corporation Tokyo Medical and Dental University
Inventors:
Dai Ujihara, Hideyuki Kanehara, Johji Inazawa, Issei Imoto
Abstract: It was determined whether SNPs in SLC4A5 are associated with salt sensitivity of blood pressure (BP). Subjects consumed an isocaloric constant diet with a randomized order of 7 days low Na+ (10 mmol/d) and 7 days high Na+ (300 mmol/d) intake. Salt sensitivity was defined as a ?7 mm Hg increase in mean arterial pressure (MAP). 35 polymorphisms in 17 candidate genes were assayed. Association analyses with salt sensitivity revealed three variants that associated with salt sensitivity, two in SLC4A5 (rs7571842, rs10177833; P<0.001), and one in GRK4 (rs1801058; P=0.020). Paradoxical changes in blood pressure in response to changes in salt intake were also found associated with a SNP for DRD2 (rs6276). In conclusion, SLC4A5 variants are strongly associated with salt sensitivity of BP in Caucasian and a DRD2 SNP is a marker for paradoxical response to salt intake.
Type:
Application
Filed:
April 22, 2013
Publication date:
May 14, 2015
Applicant:
University of Virginia Patent Foundation
Inventors:
Robin A. Felder, Robert M. Carey, John E. Jones, Pedro A. Jose, Scott M. Williams
Abstract: Compositions and methods for detecting bladder cancer are provided. In some embodiments, methods of monitoring recurrence of bladder cancer are provided. In some embodiments, the methods comprise detecting a set of markers consisting of CRH, IGF2, KRT20, and ANXA10.
Type:
Application
Filed:
April 19, 2013
Publication date:
May 14, 2015
Inventors:
Russell Higuchi, Stacey Ellen Wallace, Edwin Wei-Lung Lai
Abstract: Disclosed is a method for characterization, in a biological sample, of circulating tumour cells (CTCs) bearing at least one marker characteristic of the tumorous nature of the cell, the marker being selected from the groups constituted by: the oncogenic proteins characteristic of the CTCs, and the tumour markers. Also disclosed is the use of this method for deciding on the implementation of a treatment for a cancer patient.
Type:
Application
Filed:
November 19, 2012
Publication date:
May 14, 2015
Applicants:
UNIVERSITE PARIS SUD XI, INSTITUT GUSTAVE ROUSSY
Inventors:
Amélie Barthelemy, Francoise Farace, Marianne Oulhen, Jean-Charles Soria, Alexander Valent, Philippe Vielh, Benjamin Besse, Emma Pailler
Abstract: The present invention relates to a Lactuca sativa seed designated 79-65 RZ, which exhibits a combination of traits including resistance against downy mildew strains B1:1 to B1:31, CA-I to CA-VIII (Bremia lactucae), currant-lettuce aphid (Nasonovia ribisnigri) biotype Nr:0, and lettuce mosaic virus (LMV), as well as having intensely red, deeply incised, three-dimensional leaves, and a medium to small plant size. The present invention also relates to a Lactuca sativa plant produced by growing the 79-65 RZ seed. The invention further relates to methods for producing the lettuce cultivar, represented by lettuce variety 79-65 RZ.
Type:
Application
Filed:
October 7, 2014
Publication date:
May 14, 2015
Inventors:
Egbert Carolus Johannes Smits, Clément Michel Bernard Morice
Abstract: The present invention relates to the field of biomarkers. More specifically, the present invention relates to the use of microRNAs to diagnose and monitor various diseases such as cancer. In particular embodiments, microRNA expression levels can serve as diagnostic biomarkers in inflammatory bowel disease-associated neoplasia (IBDN). More specifically, in certain embodiments, the present invention can be used to differentiate or distinguish IBDN from sporadic colorectal cancer (S-CRC), IBD-Dysplasia, IBD and/or normal.
Abstract: Methods, devices, compositions and kits are provided for analysis of the microbiome or individual components thereof in an individual. The methods find use in a determination of infection, in analysis of the microbiome structure, in determining the immunocompetence of an individual, and the like. In some embodiments of the invention, the individual is treated with a therapeutic regimen, e.g. drugs, diet, radiation therapy, and the like.
Type:
Application
Filed:
November 7, 2014
Publication date:
May 14, 2015
Inventors:
Iwijn de Vlaminick, Michael Kertesz, Kiran Kaur Khush, Mark Alec Kowarsky, Lance Martin, Stephen R. Quake, Hannah Valantine
Abstract: The present invention relates to a method and a kit of parts for detecting the presence or absence of one or more target nucleic acid sequences in a sample, the method comprising a sequence of steps for pre-amplifying the sample by means of a polymerase chain reaction, followed by a sequence of steps comprising an isothermal amplification of the pre-amplified sample, wherein the isothermal amplification comprises a pair of primers comprising a forward primer having a 3? part that is substantially complementary to a first part of the target sequence, the presence or absence of which is to be detected, and a 5? part that is substantially homolog to a second part of the target sequence, and a reverse primer comprising a 3? part that is substantially homolog to a fourth part of the target sequence and a 5? part that is substantially complementary to a third part of the target sequence.
Abstract: The invention relates to novel variants that associate with Alzheimer's disease AD and their use in kits as a means for diagnosing AD; and also their use in nucleic acid molecules or cells/cell lines for identifying novel therapeutic, label of identification means.
Type:
Application
Filed:
April 14, 2014
Publication date:
April 30, 2015
Applicant:
University College Cardiff Consultants Limited
Abstract: The present invention relates to biomarkers and diagnostic and prognostic methods for Alzheimer's disease and other neurodegenerative disorders. The invention also provides compositions for detecting the biomarker as well as compositions and methods useful for treating Alzheimer's disease and other neurodegenerative disorders.
Abstract: The use of Akt3 as a biomarker for detecting the occurrence of epithelial-to-mesenchymal transition (EMT) in a subject, and the use of Akt3 inhibitors to treat cancer is disclosed herein. Also disclosed are various methods for detecting the occurrence of epithelial-to-mesenchymal transition (EMT) in a subject by measuring Akt3 expression and/or activity.
Abstract: The invention provides a computer-implemented method and system for predicting quantitatively whether an adjuvant or neoadjuvant chemotherapeutic treatment will be or is being successful in treating an individual suffering from cancer.
Type:
Application
Filed:
April 30, 2013
Publication date:
April 30, 2015
Applicant:
ROYAL COLLEGE OF SURGEONS IN IRELAND
Inventors:
Jochen Prehn, Andreas Lindner, Heinrich Huber
Abstract: The present invention relates to a Lactuca sativa seed designated 45-189 RZ, which may exhibit a combination of traits including resistance to downy mildew (Bremia lactucae) races Bl:1 to Bl:31 and CA-I to CA-VIII, currant lettuce aphid (Nasonovia ribisnigri) biotype Nr:0, root aphids (Pemphigus bursarius), as well as having a medium head size, large outer leaves, and moderately glossy leaves. The present invention also relates to a Lactuca sativa plant produced by growing the 45-189 RZ seed. The invention further relates to methods for producing the lettuce cultivar, represented by lettuce variety 45-189 RZ.
Type:
Application
Filed:
October 29, 2014
Publication date:
April 30, 2015
Inventors:
Maria Helena ROOSENBOOM-KOOIJMAN, Willem VAN VLIET, Floor Cathleen VAN MALLAND-DEN OTTER
Abstract: The present invention relates to a Lactuca sativa seed designated 79-504 RZ, which may exhibit a combination of traits including resistance against downy mildew strains Bl:1 to Bl:31, CA-I to CA-VIII (Bremia lactucae), currant-lettuce aphid (Nasonovia ribisnigri) biotype Nr:0, and lettuce mosaic virus (LMV), as well as an extraordinary high number of substantially equally sized leaves, which leaves are medium green, slightly to moderately blistered, and have a slightly to moderately undulated apical leaf margin, which is shallowly dentate. The present invention also relates to a Lactuca sativa plant produced by growing the 79-504 RZ seed. The invention further relates to methods for producing the lettuce cultivar, represented by lettuce variety 79-504 RZ.
Type:
Application
Filed:
October 28, 2014
Publication date:
April 30, 2015
Inventors:
Cornelis Marinus Moor, Hubertus Joseph Wilhelmus Crins
Abstract: Described herein are methods and kits for the detection of endothelial cell injury and/or activation and to the diagnostic of transplant antibody mediated rejection (ABMR). The invention further relates to methods and kits for diagnosing endothelial to mesenchymal transition (EndMT). In various embodiments, the methods comprise assessing expression of one, two or three biomarkers selected from Fascin1, Vimentin and Hsp47.
Abstract: The subject matter of the present invention is a method for the diagnosis or prognosis, in vitro, of lung cancer, which includes a step of detecting at least one expression product of at least one HERV nucleic acid sequence, a method for use of said nucleic acid sequences, which have been isolated, as a molecular marker or molecular markers, and a kit including at least one binding partner specific for at least one of the expression products of the HERV nucleic acid sequences.
Type:
Application
Filed:
December 20, 2012
Publication date:
April 30, 2015
Applicant:
BIOMERIEUX
Inventors:
Philippe Perot, François Mallet, Cécile Montgiraud, Nathalie Mugnier
Abstract: Disclosed is a microcapsule encoded depending on the kind of a target substance included therein. The encoded microcapsule has a hydrophilic liquid core including the target substance and a hydrophobic shell surrounding the liquid core. The encoded microcapsule includes graphical codes introduced on the surface of the shell.
Abstract: The application describes a method of screening for breast cancer by testing fro the amount of HAGE (Helicase antigen) in a sample of breast tissue. Methods of prognosis of samples of breast cancer tumours are also provided. HAGE+ ER? (estrogen receptor-) cancers are indicated as being amenable to chemotherapy. Methods of treating breast cancers with HAGE-specific CTA antigen or HAGE-specific antibodies are also provided.
Type:
Application
Filed:
March 27, 2013
Publication date:
April 30, 2015
Inventors:
Adam Linley, Morgan Mathieu, Stephanie Mcardle, Chungui Lu, Robert Rees
Abstract: This disclosure provides a method for determining if a patient is likely to, or not likely to, experience ovarian cancer utilizing SP17 as a biomarker. It also provides methods and therapies to treat patients identified as at risk for ovarian cancer or alternatively, as identified as having a poorer prognosis.
Type:
Application
Filed:
September 12, 2012
Publication date:
April 23, 2015
Applicants:
University of Southern California, Texas Tech University System
Inventors:
Wijbe Martin Kast, Maurizio Chiriva-Internati
Abstract: A system and method for systematically generating potential metal-organic framework (MOFs) structures given an input library of building blocks is provided herein. One or more material properties of the potential MOFs are evaluated using computational simulations. A range of material properties (surface area, pore volume, pore size distribution, powder x-ray diffraction pattern, methane adsorption capability, and the like) can be estimated, and in doing so, illuminate unidentified structure-property relationships that may only have been recognized by taking a global view of MOF structures. In addition to identifying structure-property relationships, this systematic approach to identify the MOFs of interest is used to identify one or more MOFs that may be useful for high pressure methane storage.
Type:
Grant
Filed:
July 6, 2012
Date of Patent:
April 21, 2015
Assignee:
Northwestern University
Inventors:
Christopher E. Wilmer, Michael Leaf, Randall Q. Snurr, Omar K. Farha, Joseph T. Hupp
Abstract: A polypeptide containing an amino acid sequence having at least 60% identity to the amino acid sequence SEQ ID No. 1 or containing at least one amino acid fragment of at least 6 consecutive amino acid residues of the amino acid sequence SEQ ID No. 1 or having immunological cross-reactivity to the amino acid sequence SEQ ID No. 1 or fragments thereof, wherein the amino acid sequence SEQ ID No. 1 codes for an allergen and the polypeptide comprises at least one T cell epitope recognized by a T cell receptor specific for a molecule having the amino acid sequence SEQ ID No. 1.
Type:
Application
Filed:
August 26, 2014
Publication date:
April 16, 2015
Applicant:
Biomay AG
Inventors:
Rudolf VALENTA, Margit Weghofer, Susanne Vrtala, Friedrich Horak, Peter Valent, Stefan Florian
Abstract: It is disclosed herein that miR-221 and miR-222 down-regulate PTEN and TIMP3 tumor suppressors, resulting in TRAIL resistance. The present invention provides research, diagnostic, and therapeutic tools and methods related to this discovery. Diagnostics, prognostics and treatments for human hepatocellular cancer and non-small cell lung carcinoma having a TRAIL resistance are particularly described herein.
Abstract: The present invention relates to compositions, biomarkers, and their use in treatment of cancer. In some embodiments, the invention relates to the use of several biomarkers in methods for determining the responsiveness of a human subject to a specific compound, methods for monitoring the efficacy of the compound, or methods for treating a human subject.
Abstract: Provided herein are methods for preventing or treating a viral infection in a subject, wherein the viral infection is mediated by a virus comprising one or more viral RNA molecules translated by a ribosomal shunting mechanism or a non-IRES mediated mechanism. The methods comprise administering to a subject an agent that reduces ribosomal protein (Rps25) expression or function. Also provided are methods of inhibiting or promoting ribosomal shunting-mediated translation or non-IRES mediated translation. Also provided are methods of screening for an agent that inhibits or promotes ribosomal shunting-mediated translation or non-IRES mediated translation.
Abstract: Using NMR/MS based metabonomics and targeted lipidomics approaches the inventors have explored the metabolic phenotypes of aging and longevity in a cohort compromising centenarians, elderly and young adults. The inventors have identified biomarkers for a reduced risk of developing ageing related chronic inflammatory disorders and propose a method of diagnosing a lifestyle that allows delaying and/or avoiding ageing related chronic inflammatory disorders using hydroxy-sphingomyelin SM-OH-22:1 as biomarker.
Type:
Application
Filed:
September 19, 2014
Publication date:
April 16, 2015
Inventors:
Sebastiano Collino, Ivan Montoliu Roura, Francois-Pierre Martin, Philippe Alexandre Guy, Serge Andre Dominique Rezzi
Abstract: The invention provides a method of assessing the risk of occurrence of progressive multifocal leukoencephalopathy (PML) in a subject as well as a method of stratifying a subject undergoing VLA-4 blocking agent treatment for suspension of VLA-4 blocking agent treatment. These methods comprise detecting the level of L-selectin (CD62L) and optionally LFA-1 expressing T cells in a sample from the subject.
Abstract: Disclosed is a composition comprising the nucleic acid and a chemical compound, said composition forming a star structure defining 3 or more stems extending from a reaction center. The stems are formed by a nucleic acid duplex and the chemical compound has been formed in the reaction center as the reaction product of 3 or more chemical groups. The advantage of the composition is that a close proximity is provided between the chemical groups in the reaction center, thereby promoting a reaction. The invention also relates to a method for preparation of the composition. The advantage of the method is that it does not require the pre-synthesis of a large number of templates and that it is not dependent upon codon/anti-codon recognition for an encoded molecule to be formed.
Type:
Grant
Filed:
May 17, 2012
Date of Patent:
April 14, 2015
Assignee:
Vipergen ApS
Inventors:
Nils Jokob Vest Hansen, Peter Blakskjaer, Margit Haahr Hansen, Lars Kolster Petersen, Tara Renee Heitner
Abstract: A method for identifying the source of animal waste is provided. The method includes taking DNA samples from a known group of animals, conducting DNA analysis on the DNA samples to prepare a genetic profile for each animal from the group, preparing a database of the genetic profiles, collecting a specimen of waste from an unknown source, conducting DNA analysis on the specimen, and comparing the DNA analysis from the specimen to the database to determine the source of the waste.
Type:
Application
Filed:
October 9, 2013
Publication date:
April 9, 2015
Applicant:
BioVet Pet Labs
Inventors:
Ashley Michelle Burnett, Cheleigh Nicole Winfree, Kathryn Ellen Oliff, Dawn Irion
Abstract: This document provides methods and materials for assessing metabolites in a sample from a mammal (e.g., human) for determining the nature and extent of colorectal cancer (CRC) metastasis. For example, the document relates to the diagnosis, staging and prognosis of CRC in a mammal.
Type:
Application
Filed:
May 14, 2013
Publication date:
April 9, 2015
Applicant:
UTI LIMITED PARTNERSHIP
Inventors:
Farshad Farshidfar, Aalim M. Weljie, Karen Kopciuk, Hans J. Vogel, Oliver F. Bathe
Abstract: A method for characterizing the risk a subject will develop an autoimmune and/or alloimmune disease following tissue transplant includes obtaining a biological sample from the subject, wherein the subject has received the tissue transplant determining in the biological sample a level of at least one protein selected from Tables 1-4, comparing the measured level of the at least one protein to a control value, and characterizing a subject as at greater risk of developing an autoimmune disease and/or alloimmune disease if the level of at least one protein determined is increased or decreased compared to the control value.
Type:
Application
Filed:
December 15, 2014
Publication date:
April 9, 2015
Inventors:
Mark Chance, Kenneth Cooke, Daniela Schlatzer
Abstract: The present invention involves the identification of biomarkers that are predictive of impeding systemic lupus erythematosus (SLE) disease flare. Methods for treating patients so identified are also provided.
Abstract: The invention pertains to a method for diagnosing or detecting lung cancer in human subjects based on ribonucleic acid (RNA) expression, in particular based on RNA from blood. The invention discloses 361 genes which are differentially expressed in blood from lung cancer patients and discloses that at least 4 of the mRNAs must be determined in order to have an AUC of at least 0.8.
Type:
Application
Filed:
July 10, 2014
Publication date:
April 9, 2015
Inventors:
Andrea HOFMANN, Joachim L. SCHULTZE, Jurgen WOLF, Andrea STARATSCHEK-JOX, Thomas ZANDER
Abstract: The present invention concerns a method for predicting the potential for aggressive growth and/or the risk to progress to high grade cancer for tumors in cell based detection procedures. In one aspect the invention concerns the detection of overexpression of cyclin-dependent kinase inhibitor gene products as a tool for predicting the progression risk and/or potential for aggressive growth of tumors. In a second aspect the invention concerns predicting the progression risk and/or potential for aggressive growth in tumors on the basis of the simultaneous co-detection of the presence of overexpression of cyclin-dependent kinase inhibitor gene products together with the expression of markers for active cell proliferation. Further the invention concerns preparations of probes for diagnosis namely for predicting the progression risk and/or the potential for aggressive growth of tumors.
Abstract: A method for assessing risk of losing a transplanted organ by a patient having an episode of acute rejection of the transplanted organ is described. The method includes obtaining from the patient a cell sample from the transplanted organ or peripheral blood, determining a level of FOXP3 in the cell sample, and correlating the level with the risk of loss of the transplanted organ, wherein, compared to a control level, a significantly greater level of FOXP3 in the cell sample from the transplanted organ or a significantly lower level of FOXP3 in the cell sample from the peripheral blood correlates with a decreased risk of loss of the transplanted organ.
Abstract: Methods are provided for identifying biomarker proteins that exhibit differential expression in subjects with a first lung condition versus healthy subjects or subjects with a second lung condition. Also provided are compositions comprising these biomarker proteins and methods of using these biomarker proteins or panels thereof to diagnose, classify, and monitor various lung conditions. The methods and compositions provided herein may be used to diagnose or classify a subject as having lung cancer or a non-cancerous condition, and to distinguish between different types of cancer (e.g., malignant versus benign, SCLC versus NSCLC).
Type:
Application
Filed:
September 19, 2014
Publication date:
March 26, 2015
Inventors:
Paul Edward Kearney, Clive Hayward, Xiao-Jun Li