Abstract: According to the present invention there is provided a use of a cyclic oligosaccharide for delaying the release of a volatile solvent from a composition, preferably a cosmetic composition, which comprises at least 50% volatile solvent. There is also provided a use of a cyclic oligosaccharide for reducing the initial harsh solvent odor impact, for example ethanolic/alcoholic odor impact of alcoholic or hydro-alcoholic compositions.

Abstract: The invention relates to a fragrancing composition comprising, in a cosmetically acceptable medium: a) at least 1% by weight relative to the total weight of the composition of at least one fragrancing substance; b) at least one volatile alcohol and/or one volatile silicone oil; c) at least one crosslinked or uncrosslinked amphiphilic copolymer of partially or completely neutralized 2-acrylamidomethylpropanesulphonic acid (AMPS) monomer (A) and at least one hydrophobic monomer (B) d) optionally at least a cellulose alkyl ether and/or an alkylcellulose alkyl ether, the alkyl radicals being linear or branched saturated C1-C4 alkyl radicals; and e) optionally water. The invention also relates to a method of fragrancing human keratinous substances and especially the skin, lips and integuments, comprising the application to the keratinous substances of the composition defined previously.

Abstract: A first embodiment is a coating for a surface comprising an electrostatic self-assembly creating one or more coating layer(s); (i) wherein one or more high molecular weight bioactive molecule(s) is bound to a protein carrier wherein said protein carrier or said bound bioactive molecule is further bound to one or more of said coating layer(s) and/or (ii) wherein one or more low molecular weight bioactive molecule(s) is/are incorporated within one or more of said layers or later introduced to said layer or layers by post-treatment. A second embodiment is a method of coating a surface comprising introducing said surface into a solution of one or more positively charged water-soluble polyelectrolytes at a pH ranging from about 2 to about 12 and at a temperature ranging from about 4° C. to about 80° C. and incubating said surface for about 0.

Abstract: The deposition of a benefit agent on a substrate after treatment of the substrate with a personal care composition which has a viscosity of at least 50 mPa·s at 25° C. and comprises the benefit agent and a low molecular weight surfactant is improved when a water-soluble polymer is used as a substitute for at least a portion of the low molecular weight surfactant. The headspace concentration of a fragrance provided by such personal care composition is also increased.

Abstract: Compositions comprising polytetramethylene glycol and a volatile material (e.g. a perfume) are able to sustainedly release said volatile material and are easy to disperse in liquid and cream products.

Abstract: The invention provides a deterioration inhibitor with an even stronger effect than the prior art against deterioration of flavors and fragrances in foods and beverages or cosmetics, which is attributed to heat, light and the like, and especially against production of deterioration odors derived from citral. It is a food flavor deterioration inhibiting material comprising as an effective component a product obtained by treatment of a tea extract component with an oxidizing enzyme. Addition of a deterioration inhibiting material according to the invention to a food or beverage or a cosmetic can inhibit deterioration of flavor and fragrance, with use in smaller amounts than conventional deterioration inhibitors. A particularly notable effect is exhibited against production of p-cresol and p-methylacetophenone which are citral-derived deterioration odor components, and therefore it is suitable for foods and beverages or cosmetics with citral-containing citrus-like flavors and fragrances.

Abstract: The present invention discloses compositions having particles comprising, inorganic element; one or more active ingredient and optionally a release rate modulating agent, suitable for the delivery of active ingredients to human and animal tissues. The particles are nanoparticles or microparticles or mixtures thereof, made preferably by sol-gel method. The compositions are useful for application to the topical or mucosal surfaces preferably in the form of creams, gels, lotions, dry powders, spray, foam and other suitable forms.

Abstract: The present invention concerns the use of an oil-in-water emulsion where the interior of oil droplets exhibit interfaces, between lipophilic domains and hydrophilic or amphiphilic domains, due to the presence of a lipophilic additive solubilized inside the oil droplets and which is used for delayed release of active elements such that the release of at least one active element, which has a octanol/water partitioning coefficient logP higher than ?1, corresponds to a higher Tmax than the Tmax obtained for the simple reference oil-in-water emulsion where no lipophilic additive is used.

Abstract: Antimicrobial agents, products and compositions incorporating the agents, and methods of using the compositions and products are provided. The antimicrobial agents comprise 1,2-cyclohexanedimethanol, 1,4-cyclohexanedimethanol, 2,2,4,4-tetramethyl-1,3-cyclobutanediol, or mixtures thereof. These agents have surprisingly been found to inhibit microbial growth at a much lower concentration than other glycols with known antimicrobial activity.

Abstract: The present invention relates generally to Apo2L/TRAIL purification involving crystallization.

Abstract: The invention pertains to a new method for formulating active fragrance ingredients in such a way as to protect them and to slow the evaporation method of said active ingredients. It relies upon the use of thickening acrylic emulsions, at a pH above 5 and containing hydrophobic groups in order to trap said active ingredients. The invention also pertains to various methods of realizing the active ingredients thus formulated: a mixture in water of these active ingredients with thickening emulsions, dispersion of solid particles of these polymers and of these active ingredients after acidification, and solid particles obtained in a dry state after water is eliminated. Finally, the invention pertains to the use of these various formulations in order to protect an active ingredient and slow its evaporation kinetic.

Abstract: An improved fragrance delivery system capable of providing controlled release of fragrance molecules in various consumer products is composed of a polymer having covalently bound fragrance moieties that are releasable in the form of fragrance molecules. Certain embodiments comprise globular polymer particles in which unbound fragrance molecules are occluded, absorbed and/or adsorbed. Certain other embodiments incorporate fragrance monomer units, which achieve reduced residuals upon complete release of the fragrance.

Abstract: The invention concerns a solid perfumed preparation with high persistency in the form of microbeads and comprising a volatile aromatic raw material, or a mixture of volatile aromatic raw materials, and one or several fusible excipients. Said preparation can further comprise one of the following constituents: one or more polymers dispersible in the melted mass formed by the constituents of the preparation, one or more mineral additives, one or more surfactants, one or more antioxidants, one or more colouring agents. The invention can be used in cosmetics and in household product industries.

Abstract: The present invention features methods for selecting a patient with an enhanced therapeutic response to a botulinum toxin treatment of a headache. In some embodiments, the methods comprise the step of identifying a patient who is not using a prophylactic headache pain medication, a patient who is overusing an acute pain medication, a patient who suffers four or more hours of headache pain per headache, a patient who has a chronic daily headache for twenty or more years, and/or a patient who has twenty or more headache days out of a 30-day-month.

Abstract: A method of stabilizing a multiphase composition is described. The composition comprises a structured surfactant phase, a benefit phase and a perfume comprising perfume raw materials. The method comprises a step of selecting at least 70% of the perfume raw materials that have a ClogP of greater than 1.8.

Abstract: Preservative systems on the basis of cationic surfactants are known i n the art, a typical example of such cationic surfactants is the ethyl ester of the lauramide of arginine monohydrochloride (LAE) (2). Besides the chloride form the corresponding bromide and sulphate salts are known. It was found that other salts of the cationic surfactants display excellent properties, such as the salts of lactic acid, glutamic acid and acetic acid. It was further found that the combination of the cationic surfactants with at least one salt of an organic or inorganic acid displayed an excellent preservative action. A further preservative system with favourable properties was the combination of the cationic surfactants with at least one ester compound, amide or enzyme inhibitor. Also the combination of the cationic surfactant with a further cationic molecule such as ethyl arginate, glucosamine or chitosan led to an effective preservative system.

Abstract: Methods for the formation of colloidal suspensions. The method includes combining an aqueous substance with a second substance that is normally immiscible with the aqueous substance, to form a mixture, and before, during or after the combining removing dissolved gases from one or both of the aqueous and second substance, whereby the aqueous and second substances mix and form a colloidal suspension. The methods for the formation of colloidal suspensions include methods for the formation of emulsions as well as particulate dispersions. The methods used to form the colloidal suspensions in accordance with the present invention produce colloidal suspensions that are stable for periods from an hour to several weeks in the absence of surfactants or stabilizing agents.

Abstract: Improved aromachemical derivatives, and fragrances and flavorings including the derivatives, that have a longer useful shelf life than the aromachemicals from which they can be derived, are disclosed. In particular, the derivatives maintain the fragrance characteristics of the aromachemicals, while lowering the allergic properties, increasing the stability, and/or increasing the odor intensity. Also disclosed are methods of making the derivatives, and articles of manufacture including the derivatives. In one embodiment, the derivatives are prepared by replacing one or more double bonds in citral with a thioether, cyclopropyl, oxirane, or thiirane group. The cyclopropane ring can be unsubstituted, or substituted with one or two lower alkyl, preferably methyl groups. The alkyl groups can optionally be substituted, for example, with electron donating groups, electron with drawing groups, groups which increase the hydrophilicity or hydrophobocity, and the like.

Abstract: A composition for controlled release of an active material such as a fragrance, sunscreen, vitamin or biocide in a product such as a hair shampoo, shower gel, another personal product such as an antiperspirant or deodorant, a household cleaning product such as a laundry detergent, hard surface cleaner or polishes, or a fabric softener, air freshener or tumble drier sheet, comprises a blend of the active material and a waxy cyclopolysiloxane. The cyclopolysiloxane is preferably substituted by hydrocarbon substituents having 12 or more carbon atoms and may also contain an aryl or aralkyl substituent.

Abstract: The invention proposes a fragrance dispenser, comprising a first and a second carrier, each carrier comprising one or more fragrance substances, wherein the fragrance substances comprise one or more fragrance substances a) with a vapour pressure of at least 0.1 mmHg at 25° C. (“HVA”) and one or more fragrance substances b) with a vapour pressure of less than 0.1 mmHg at 25° C. (“LVA”), and wherein the fragrance substances are distributed to the first and second carrier such that at least 80 wt.-% of all HVA fragrance substances are carried by the first carrier.

Abstract: The present invention relates to the ability of SAP to suppress the differentiation of monocytes into fibrocytes. It also relates to the ability of IL-12, laminin-1, cross-linked IgG and IgG aggregates to suppress the differentiation of monocytes into fibrocytes. Methods and compositions for suppressing differentiation of monocytes into fibrocytes using these proteins are provided. These methods are useful in a variety of applications including treatment and prevention of fibrosing diseases such as scleroderma, pulmonary fibrosis and asthma. Finally, the invention includes assays for detecting the ability of various agents to modulate monocyte differentiation into fibrocytes and to detect monocyte defects. Such assays may also be used to diagnose scleroderma, pulmonary fibrosis, or other fibrosing diseases.

Abstract: The present invention relates to photo-labile pro-fragrance conjugates comprising: a) a photo-labile unit which upon exposure to electromagnetic radiation is capable of releasing a pro-fragrance unit; and b) a pro-fragrance unit, which when so released is either i) a pro-fragrance compound capable of releasing a fragrance raw material; or ii) a fragrance raw material. The present invention relates to systems for delivering fragrances to a situs, and to laundry detergent compositions, fine fragrances, personal care and hair care compositions comprising said systems.

Abstract: The present invention relates to [1] a method for keeping a quality of 2-methyl-3-(3,4-methylenedioxyphenyl)propanal useful as a perfume, which comprises incorporating from 50 to 3000 ppm of 1-acetyl-3,4-methylenedioxybenzene in the 2-methyl-3-(3,4-methylenedioxyphenyl)propanal; [2] a process for producing 2-methyl-3-(3,4-methylenedioxyphenyl)propanal having a content range from 50 to 3000 ppm of 1-acetyl-3,4-methylenedioxybenzene; and [3] 2-methyl-3-(3,4-methylenedioxyphenyl)propanal having a content range from 50 to 3000 ppm of 1-acetyl-3,4-methylenedioxybenzene.

Abstract: Perfume compositions having functional perfume components for aiding in perfume evaporation. The functional perfume components have a Kovat's index in the range of 900-1400 and an ODT of greater than about 1 ppb. In one embodiment, the functional perfume component may be present in an amount from at least about 10% by weight of the composition. In another embodiment, the composition containing a function perfume component is substantially free of a VOC.

Abstract: The present invention relates to the use of at least one flavonoid for odour improvement and/or odour stabilisation, and to corresponding compositions and the preparation thereof.

Abstract: The present invention relates to a delivery system based on a film of an imine forming liquid crystalline phase, mixed with at least with one biologically active substance, to which a constant or variable electric field can be applied. The delivery system can be used as a delivery system for biologically active substances such as flavors, fragrances, bactericides, fungicides, insecticides, insect attractants or repellents, agrochemicals or pharmaceuticals.

Abstract: The invention relates to the field of encapsulating aromas with cyclodextrins. In particular, it relates to methods for spray drying aromas to produce aroma/cyclodextrin particles and to the resultant particles themselves.

Abstract: Therapeutic uses of inhibitors of the Lymphotoxin Pathway to treat tumors, specifically to treat follicular lymphomas.

Abstract: The present invention relates to a benefit agent delivery system that can, when directly applied to a substrate, provide a longer benefit term than when a benefit agent alone is applied to said substrate. Typical benefit agents include perfume raw materials such as perfume aldehydes and ketones.

Abstract: The invention describes the unexpected characteristics of blends, including crosslinked reaction products of elastomeric silicone polymers with various polyurethanes and their applications in personal care products.

Abstract: Cyclodextrin inclusion complexes, guest stabilizing systems, and methods for preparing and using the same. Some embodiments of the present invention provide a method for making a guest stabilizing system. The method can include mixing cyclodextrin, a solvent and a guest to form a cyclodextrin inclusion complex. The method can further include adding uncomplexed cyclodextrin to the cyclodextrin inclusion complex to form a guest stabilizing system. Some embodiments of the present invention provide a method for making a beverage that can include mixing uncomplexed cyclodextrin, a guest and a solvent to form a beverage.

Abstract: An emulsion includes a substantially continuous liquid medium, and a plurality of droplet structures dispersed within the substantially continuous liquid medium. Each droplet structure of the plurality of droplet structures includes an outer droplet of a first liquid having an outer surface; an inner droplet of a second liquid having an inner surface contained within the outer surface of the outer droplet of the first liquid, the second liquid being immiscible in the first liquid, wherein the inner and outer droplets have a boundary surface region therebetween; an outer layer of block copolymers disposed on the outer surface of the outer droplet; and an inner layer of block copolymers disposed on the inner surface of the inner droplet. The block copolymers include a hydrophilic polymer block and a hydrophobic polymer block that act in combination to stabilize the droplet structure, and the first liquid is immiscible in the substantially continuous liquid medium.

Abstract: The use of a first fabric care composition comprising a first perfume delivery agent to treat a fabric and subsequently and independently treating the fabric using a second fabric care composition comprising a second perfume delivery agent provides a synergistic odor benefit on the fabric.

Abstract: A composition for controlled release of an active material such as a fragrance, sunscreen, vitamin or biocide in a product such as a hair shampoo, shower gel, another personal product such as an antiperspirant or deodorant, a household cleaning product such as a laundry detergent, hard surface cleaner or polishes, or a fabric softener, air freshener or tumble drier sheet, comprises a blend of the active material and a waxy cyclopolysiloxane. The cyclopolysiloxane is preferably substituted by hydrocarbon substituents having 12 or more carbon atoms and may also contain an aryl or aralkyl substituent.

Abstract: This invention relates to a composition and method of increasing the substantivity of a fragrance deposited on to a human substrate and to a fluid composition for use therein.

Abstract: The present invention relates to topical bioadhesive formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl lipid and/or at least one tocopherol; b) at least one phospholipid; c) at least one biocompatible oxygen containing, low viscosity organic solvent; wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament.

Abstract: The invention relates to the use of compounds of formula (X—Ar—Y), in which X and Y respectively are selected independently of one another from the groups H, C-1-8 alkyl and groups as per formulae (Ia), (Ib) or (Ic), together with other groups that are defined as cited in the description, as antioxidants. The invention also relates to corresponding novel compounds and preparations and to corresponding production methods for said compounds and preparations.

Abstract: Copolymers having linked internal polyether blocks and internal polyamide blocks have advantageous physical properties and solvent-gelling abilities. The copolymer may be prepared from a reaction mixture that contains 1,4-cyclohexane dicarboxylic acid (CHDA) and poly(alkyleneoxy)diamine (PAODA). Optionally, the reaction mixture contains no monofunctional compound reactive with either amine or carboxylic acid groups, however some of this monofunctional compound may be present. Dimer diamine and/or dimer acid may be present in the reaction mixture. A copolymer may also be prepared from a reaction mixture containing dimer acid and at least two diamine compound(s) including PAODA and short-chain aliphatic diamine having 2-6 carbons (SDA), wherein: a) the reaction mixture comprises x grams of PAODA and y grams of SDA, and x/(x+y) is 0.8-0.98; b) the reaction mixture weighs z grams, and x/z is at least 0.

Abstract: Disclosed are stabilized body care products, household products, textiles and fabrics which comprise certain dialkylhydroxyamine stabilizers, dialkylhydroxylamine stabilizer salts, nitrone stabilizers or amine oxide stabilizers. Dyed products and articles are effectively stabilized against color degradation. The products are for example skin-care products, hair-care products, dentifrices, cosmetics, laundry detergents and fabric softeners, non-detergent based fabric care products, household cleaners and textile-care products.

Abstract: Provided are personal care products and compositions that comprise at least one preservative compound selected from the group consisting of phenoxyethanol, 2-phenyl ethanol, phenoxypropanol, 3-phenylpropanol and benzylalcohol, in a total concentration of 0.1 to 1% (w/w); and at least one preservative enhancer compound selected from the group consisting of 4-methylbenzaldehyde, heliotropine, vanilline, 4-hydroxybenzaldehye, 3-hydroxybenzaldehyde, 4-methoxybenzaldehyde, 3-methoxybenzaldehyde, 2,4-dihydroxybenzaldehyde, 3-hydroxy-4-methoxybenzaldehyde, 3,5-dihydroxybenzaldehyde, and 4-hydroxy-2-methoxybenzaldehyde, in a total concentration of 0.05 to 0.5% (w/w), in a cosmetically acceptable base. The composition does not contain certain classic bactericidal, fungicidal, sporicidal or preservative compounds. Further provided are methods of forming such compositions and products and the use of preservatives and preservative enhancers in such compositions and products.

Abstract: The present invention relates to compositions of UV absorbers and optionally additional antioxidants. The compositions are useful for the protection and stabilization of photosensitive ingredients such as colorants, dyes, scents, fragrances and active ingredients in body care products, household products or inks against the deleterious effects of ultraviolet radiation and oxygen.

Abstract: The present Invention relates to a preservative composition comprising: a mixture of two to ten of well characterized fragrance raw materials with a cosmetic function, of which at least two are selected from: allyl caproate, benzyl acetate, benzaldehyde, dihydrolsojasmonate, ethyl phenethylacetal, ethyl cinnamate, ethyl methyl phenyl glycidate, ethyl vanillin, 2-heptylcyclopentanone, geranyl acetate, heliotropine, cis-hex-3-en-1-ol, ethylene brassylate, nonalactone gamma, camphylcyclohexanol, undecalactone gamma, 2-t-butylcyclohexylacetate, pentyl salicylate, 2-phenylethanol and 2-phenylethyl acetate; and are contained in at least 20% by weight of said mixture; at least one preservative; and a sequestrant.

Abstract: The invention relates to an ethanol-free or alcohol-free composition. This ethanol-free or alcohol-free composition comprises a hydrofluoro ether and is characterized in that it comprises at least one ester of a polyacid, preferably a hydroxylated polyacid. This composition can be used in the preparation of perfume compositions such as perfumes and toilet waters.

Abstract: The present invention provides preventive and/or therapeutic drugs for cancer and chronic rheumatoid arthritis which contain a peptide having a CXCR4 antagonism, its amide, its ester or its salt. Also, the present invention provides a novel peptide having a CXCR4 antagonism, its amide, its ester and its salt.

Abstract: The deposition of a benefit agent on a substrate after treatment of the substrate with a personal care composition which has a viscosity of at least 50 mPa·s at 25° C. and comprises the benefit agent and a low molecular weight surfactant is improved when a water-soluble polymer is used as a substitute for at least a portion of the low molecular weight surfactant. The headspace concentration of a fragrance provided by such personal care composition is also increased.

Abstract: Methods and compositions are provided for protecting or enhancing excitable tissue function in mammals by systemic administration of an erythropoietin receptor activity modulator, such as erythropoietin, which signals via an EPO-activated receptor to modulate the function of excitable tissue. Excitable tissues include central neuronal tissues, such as the brain, peripheral neuronal tissues, retina, and heart tissue. Protection of excitable tissues provides treatment of hypoxia, seizure disorders, neurodegenerative diseases, hypoglycemia, and neurotoxin poisoning. Enhancement of function is useful in learning and memory. The invention is also directed to compositions and methods for facilitating the transport of molecules across endothelial cell tight junction barriers, such as the blood-brain barrier, by association of molecules with an erythropoietin receptor activity modulator, such as an erythropoietin.

Abstract: The present invention relates to a humectant composition containing, as component (A), at least one member selected from a menthol derivative represented by the following formula (1) and p-menthane-3,8-diol: in which R is an alkylene group having 2 to 5 carbon atoms which may be substituted with at least one member selected from the group consisting of a methyl group and a hydroxyl group, and n is an integer of 1 to 3. The humectant composition of the present invention provides an excellent moisture-retention effect.

Abstract: The present invention relates to methods and compositions for using photostabilizer compounds for stabilizing formulation ingredients, like flavors, fragrances, colors, antioxidants, polymers, within cosmetics, personal care and household products, against degradation from sun light, heat and air oxidation resulting in improvement in storage stability, viscosity, and maintenance of color of the formulated products.

Abstract: The present invention relates to personal treatment compositions, which contain encapsulated perfume compositions, which release a burst of fragrance a period of time after initial topical application. According to the present invention, the burst of fragrance is released with the application of mechanical pressure on the encapsulated perfume composition. Further, the present invention relates to hair and skin compositions, which release a burst of fragrance a period of time after initial topical application by rubbing the skin or brushing the hair.

Abstract: A method for applying air freshener within an automobile is disclosed. The method includes the steps of retrieving an air freshener card, locating a substantially hidden position within the automobile, and placing the air freshener card at the substantially hidden position. An air freshener card and method for making the same is also disclosed.