Abstract: The present invention relates to methods for preparing &bgr;-ketoester fragrance pro-accords from activated acyl units, 1,3-dioxan-4,6-diones and fragrance raw material alcohols. The first step involves contacting an activated acyl unit, preferably an acid chloride, with a 1,3-dioxan-4,6-dione, an example of which is Meldrum's acid, to form a 2-acyl 1,3-dioxan-4,6-dione which is then reacted with a fragrance raw material alcohol to form the final &bgr;-ketoester fragrance pro-accord. The resulting &bgr;-ketoester fragrance pro-accords are suitable for use in laundry detergent, personal care, and other formulations wherein aesthetic fragrance materials are employed.

Abstract: The compounds are (+)- and (−)-2-cyclododecylpropanol and (+)- and (−)-2-cyclododecylpropionic acid, and salts thereof. (−)-2-cyclododecylpropanol is suitable as a fragrance while the virtually odorless (+) enantiomer is suitable as a fixative for other fragrances. The two enantiomers of 2-cyclododecylpropanol are prepared by reduction of the acid function of the enantiomers of 2-cyclododecylpropionic acid.

Abstract: The present invention describes a fragrance delivery system which releases fragrant aldehydes or ketones and/or fragrant compounds containing an olefin function upon exposure to light. This system comprises &agr;-keto esters of formula in which R′* and R″* have the meaning as defined in the application and which are generally, in case of R′*, an alkyl group carrying an abstractable hydrogen in &ggr;-position relative to the &agr;-keto function and carrying a moiety from which is derived a fragrant compound containing an olefin function, and, in case of R″*, the organic part of a primary or secondary alcohol from R″*OH which is derived a fragrant aldehyde or ketone.

Abstract: Agents which increase the levels of human insulin-like growth factor—1 binding protein (h-IGFBP-1), such as an estrogen, are used in conjunction with a gonadotropin releasing hormone (GnRH) analogue in the treatment of PCOD and associated infertility.

Abstract: Ultraviolet absorbents and photostabilizers have an excellent absorption ability in a wide range of ultraviolet rays, and also have high stability and high safety. The ultraviolet absorbent and photostabilizer include a pyridazine derivative of the formula (1): or salts thereof. Also, described are methods for manufacturing said pyridazine derivative and/or this salts thereof comprising the process of reacting at least 10 wt % of 4,5-dichloro-3-hydroxypyridazine or 4,5-dibromo-3-hydroxypyridazine or mixtures thereof with at least 20 vol % of morpholine in reaction solution at 70° C. or higher. The ultraviolet absorbents photostabilizers include said pyridazine derivative and/or salts thereof as effective ingredient. An ultraviolet ray absorption composition and an external preparation for skin are also included.

Abstract: The present invention has multiple aspects. In particular, in one aspect, the present invention is directed to a unit dose comprising 0.2 &mgr;g/kg to 36 &mgr;g/kg of a recombinant FGF or an angiogenically active fragment or mutein thereof. In another aspect, the present invention is directed to a pharmaceutical composition comprising an angiogenically effective dose of an FGF or an angiogenically active fragment or mutein thereof, and a pharmaceutically acceptable carrier. Typically, the angiogenically effective dose comprises 0.2 &mgr;g/kg to 36 &mgr;g/kg of an FGF of any one of SEQ ID NOS: 1-3, 5, 8-10 or 12-14 or an angiogenically active fragment or mutein thereof.

Abstract: A fragrant potpourri gel mixture is disclosed for dispensing fragrance to the air from a container, with the mixture lacking free liquids and being pourable into or out of the container. The fragrant potpourri gel mixture is prepared by providing an aqueous-based liquid, adding a bittering agent, and combining a coloring agent to form an aqueous-based mixture. An oil-based compound having a volatile fragrance oil component is added to the aqueous-based liquid. An absorbent polymer is mixed in by agitation or stirring to absorb the aqueous-based liquid within a gel mixture and to emulsify the oil-based fragrance component throughout to form a heterogeneous gel mixture having a plurality of micro-droplets of oil fragrance components and air pockets suspended therein. The heterogeneous gel mixture is prepared at room temperatures without heating. The volatile fragrance components of the micro-droplets volatilize from the surfaces of the micro-droplets when exposed to the air.

Abstract: The present invention is a trimethylcyclohexane derivative represented by Formula (1): wherein A represents C═O or CH—OH, n represents 2, R1 represents hydrogen or a methyl group, R2 represents a straight or branched, saturated or unsaturated hydrocarbon group having 3 to 10 carbon atoms, and a dotted line represents a saturated or unsaturated carbon-carbon bond, a melanin production inhibitor and a fragrance fixative comprising one or more of the trimethylcyclohexane derivatives, and a dermal formulation comprising one or more of the melanin production inhibitors and/or fragrance fixatives.

Abstract: This invention relates to a method of enhancing wound healing and to a method of enhancing organ transplantation utilizing scatter factor, either alone or in combination with a growth factor.

Abstract: The invention concerns a perfume composition comprising a perfume base and a lipophilic solubilizing agent based on at least an organopolysiloxane having according to Hansen solubility parameter the following characteristics: &dgr;D London interactions ranging from (8) to (21) (J/cm3)½, &dgr;P of Keesom interactions greater than 0 and capable of reaching 25 (J/cm3)½, &dgr;H of hydrogen binding ranging from (0) to (23) (J/cm3)½. Said organotrisiloxanes with polar or polarizsable function of formula (I) are used as solubilizing agents and emollients in perfume composition.

Abstract: The present invention provides a fragrance delivery vehicle including a water insoluble oil, a conditioner containing a cationic active at a level above about 0.5%(wt), and at least about 0.1%(wt) of a fragrance composition comprising a first aroma chemical with a clogP of 3.0 or less and a second aroma chemical having a clogP of at least 4.0. Processes for conditioning and fragrancing a substrate, for enhancing the fragrance of a consumer product, and for designing a fragrance delivery vehicle are also provided.

Abstract: The invention has an object of providing a hinokitiol which is not damaged in the antibacterial activity and improved in the water solubility, heat stability (anti-sublimation characteristics) and corrosion to metals and also providing a composition comprising a hinokitiol. The invention resides in a clathrate compound comprising clathration of hinokitiols by using a branched cyclodextrin such as a branched &bgr;-cyclodextrin. The clathrate compound can be used in various applications requiring an antibacterial activity, such as hair cosmetics, bath agents, skin cosmetics and oral compositions.

Abstract: The present invention concerns processes for the production of dry, partially amorphous products containing biologically active and in particular therapeutically active material which are macroscopically homogeneous substance mixtures, the substance mixtures being selected from at least one substance of each of the groups

Abstract: The invention relates to fragrance precursors, In particular, the invention relates to the use of several classes of compounds which may act as fragrance precursors, e,g., in cosmetic products such as deodorants and antiperspirants and in laundry products such as detergents and fabric softners. These compounds are odorless, but upon contacting the skin as example, in skin care compositions or in personal care compositions, produce fragrances. The compounds also produce fragrances when used in the presence of lipases, e.g. as used in (laundry) detergents, thus providing a prolongation of the fabric scenting effect. The compounds under consideration are compounds of the formula I: The substituents are defined in the specification.

Abstract: [pre-glass agglomeration] A method of making a fragrance delivery system comprising forming fused microspheres and incorporating a fragrance therein. The method relates to the mixing together of two separate factions comprising a silicate part and a modifier part, drying the mixture, heating the mixture to form an agglomeration, removing any free-flowing spheres from the agglomeration, soaking the agglomeration in fragrances or essential oils, and then drying the agglomeration. [incorporated therein. The preglass agglomeration has an extended fragrance release time exceeding a year and a half, and uses microcapillary action to quickly uptake oils and alcohols. The pre-glass agglomeration provides a slow release of fragrance without the escape of any residual liquid. The pre-glass agglomeration may be replenished, an unlimited number of times, with fragrance containing oils and alcohols after the odor fades. The pre-glass agglomerations can be molded and may be colored or dyed.

Abstract: Compositions and methods are described for the induction of apoptosis inhibition of DNA synthesis, and/or inhibiting COX-2 activity using an effective amount of salts of aminoimidazole carboxamide, 5 amino 1,2,3-triazoles or a combination of salts thereof.

Abstract: Detergent compositions containing certain acetals or ketals which hydrolyze upon exposure of surfaces washed in solution of said compositions to a reduction in pH, thereby releasing a fragrance which is characteristic of one or more of the hydrolysis products. The acetals and ketals themselves also form part of the invention; they have a molecular weight of at least about 350; a ClogP of about 4, and a half-life of less than 60 minutes when measured at pH=0 by the pro-fragrant hydrolysis test.

Abstract: The present invention describes a fragrance delivery system which releases fragrant aldehydes or ketones and/or fragrant compounds containing an olefin function upon exposure to light. This system comprises &agr;-keto esters of formula in which R′* and R″* have the meaning as defined in the application and which are generally, in case of R′*, an alkyl group carrying an abstractable hydrogen in &ggr;-position relative to the &agr;-keto function and carrying a moiety from which is derived a fragrant compound containing an olefin function, and, in case of R″*, the organic part of a primary or secondary alcohol from R″*OH which is derived a fragrant aldehyde or ketone.

Abstract: Methods for treating prostate cancer are disclosed. The methods of the invention generally feature administration to a subject of an LHRH-R antagonist, in combination with a second therapy. In one embodiment, this second therapy is performance of a procedure that removes or destroys prostatic tumor tissue, such as a radical prostatectomy, cryosurgery or X-ray therapy (external or interstitial). In another embodiment, the second therapy is treatment with an LHRH-R agonist, either simultaneous with or subsequent to LHRH-R antagonist therapy. The methods of the invention can further involve administering an antiandrogen and/or an inhibitor of sex steroid biosynthesis to the subject in combination with the LHRH-R antagonist.

Abstract: Perfume is absorbed within organic polymer particles which have a further polymer at their exterior. The further polymer incorporates free hydroxyl groups and serves to promote deposition of the particles from a wash or rinse liquor. The further polymer may be part of an encapsulating shell, but more conveniently is used as a stabilizer during polymerization of the particles. Highly hydrolyzed polyvinyl alcohol is preferred.

Abstract: Described is a single phase aqueous surfactant-free nontoxic air freshening composition containing 30-70% water, 5-20% of a fragrance, at least 60% of the components of which has a C log10P≦2.5 and 30-60 weight percent of a mixture of two glycol ether components: (i) dipropylene glycol methyl ether; and (ii) propylene glycol propyl ether or propylene glycol butyl ether. Also described is an air freshener device comprising a vessel for the aforementioned composition, an emanating surface and a wick for supplying the composition to the emanating surface.

Abstract: A perfume fixative consisting essentially of polyvinylpyrrolidone, hydroxy propyl cellulose and hydrophobic oil. The perfume fixative is being incorporated in a perfume-containing formulation or product. The fixative is found to be effective in enhancing perfume life, even when utilized at low levels.

Abstract: A method for applying air freshener within an automobile is disclosed. The method includes the steps of retrieving an air freshener card, locating a substantially hidden position within the automobile, and placing the air freshener card at the substantially hidden position. An air freshener card and method for making the same is also disclosed.

Abstract: Fragrant silanes having the formula:(R.sup.1 O).sub.a (R.sup.2 O).sub.b (R.sup.3 O).sub.c (R.sup.4).sub.d (R.sup.5).sub.e SiR.sup.6where R.sup.1, R.sup.2 and R.sup.3 are derived from the group of alcohols consisting of R.sup.1 OH, R.sup.2 OH and R.sup.3 OH wherein R.sup.1 OH, R.sup.2 OH and R.sup.3 OH are fragrant alcohols or alternatively R.sup.1, R.sup.2 and R.sup.3 are derived from the group of fragrant esters, ketones, or aldehydes having the structure:R.sup.7 --CH.sub.2 (C.dbd.O)--R.sup.8wherein the fragrant ester, ketone or aldehyde is capable of exhibiting the enol form of the carbonyl moiety under reaction conditions, with R.sup.4 and R.sup.5 selected from the group consisting of monovalent hydrocarbon radical having from one to forty carbon atoms and monovalent alkoxy radicals having from one to forty carbon atoms, R.sup.

Abstract: A composition comprising: an organic chemical having a chemical group having a dipole moment of at least about 1.5 Debyes and a chemical linker selected from the group consisting of carboxylic acids having 4 to 6 carbon atoms, an ethoxylated polyhydric alcohol, a polyvinyl pyrrolidone and a polyethylene glycol having a molecular weight of about 600 to about 10,000, wherein the molar ratio of organic chemical to chemical linker is about 4:1 to 1:4.

Abstract: The present invention provides compounds of formula I: ##STR1## wherein R.sup.1 is hydrogen or methyl and R.sup.2 is alkyl. These compounds are useful as fixatives in fragrance compositions. Processes of making such compounds are also provided.

Abstract: The present invention is drawn to a method of controlling gene expression in plants. Specifically, the method comprises obtaining a transgenic plant comprising at least two receptor expression cassettes and at least one target expression cassette. The first receptor expression cassette comprises a nucleotide sequence for a 5' regulatory region operably linked to a nucleotide sequence which encodes a first receptor polypeptide, and a 3' termination region. The second receptor expression cassette comprises a nucleotide sequence for a 5' regulatory region operably linked to a nucleotide sequence which encodes a second receptor polypeptide, and a 3' termination region.

Abstract: The invention relates to a preparation which comprises perfume, polymer, aluminium stearate and essentially water. This gives a product which can be produced very easily at low cost and which has an unexpectedly linear fragrance release over a period of more than four weeks.

Abstract: The present invention relates to silicone-containing compositions and to use thereof in various household products such as personal care products, laundry and household cleaners, bleaching compositions and the like. In particular, it relates to silicone-containing lipophilic compositions based on flavorants, perfumes, coolants or antimicrobial agents as lipophiles and which display improved residuality, impact and/or efficacy on surfaces treated therewith, for example, teeth, dentures, skin, hair, laundry, dishware, working surfaces and the like. In addition, it relates to silicone-containing bleach compositions which additionally contain bleach-sensitive ingredients such as perfumes, flavorants and the like which display improved stability.

Abstract: The present invention relates to perfume and fragrance pro-accords which are suitable for use in personal care and personal hygiene compositions as fragrance delivery systems. The pro-accords of the present invention slowly release fragrance raw materials upon contact with human skin thereby providing a prolonged fragrance benefit. The pro-accords serve as a means for delivering any fragrance raw material as well as other adjunct materials inter alia astringents, carriers, and diluents.

Abstract: Methods for preparing soft gelatin capsules containing fragrances are disclosed. The desired fragrance is dissolved in a solvent system comprising a volatile solvent, a non-volatile cosolvent, or a combination of a volatile solvent and a non-volatile cosolvent or cosolvents. The resulting mixture is then encapsulated between gelatin ribbions prepared with an odor-free gelatin plasticized with a partially dehydrated, hydrogenated glucose syrup.

Abstract: The present invention relates to a fragrance delivery system which comprises one or more .beta.-ketoester pro-fragrances or pro-accords, said fragrance delivery system useful in a stable, preferably clear, aqueous odor-absorbing composition. The odor-absorbing composition can be further characterized in that they comprise solublized, uncomplexed cyclodextrin, and cyclodextrin compatible antimicrobial actives, cyclodextrin compatible surfactants, cyclodextrin compatible humectants, or mixtures thereof. The aqueous odor-absorbing composition are for use on inanimate surfaces, especially fabrics, and more specifically, clothes, in order to restore and/or maintain freshness by reducing malodor without the need for washing or dry cleaning.

Abstract: The present invention is directed to a pro-fragrance compound selected from the group consisting of an acetal, a ketal, and mixtures thereof, wherein at least one of a parent aldehyde, ketone, or alcohol of the pro-fragrance acetal or ketal is a fragrance compound, having a ClogP of less than about 4. The ClogP is the logarithm to the base 10 of the octanol/water partition coefficient of the pro-fragrances. Further disclosed are detergent compositions comprising the pro-fragrance compound of the present invention and detersive surfactants.

Abstract: The present invention relates to perfume and fragrance pro-accords which are suitable for use in personal care and personal hygiene compositions as fragrance delivery systems. The pro-accords of the present invention slowly release fragrance raw materials upon contact with human skin thereby providing a prolonged fragrance benefit. The pro-accords serve as a means for delivering any fragrance raw material as well as other adjunct materials inter alia astringents, carriers, and diluents.

Abstract: Fragrance releasing silicon compounds either as siloxanes or silanes may be emulsified to form water-in-oil or oil-in-water emulsions. Further non-aqueous emulsions of two or more non-aqueous immiscible phases one of which contains a fragrance releasing silicon compound may be prepared by utilizing the emulsion stabilizing properties of a particulate elastomer dispersion in a volatile silicone compound.

Abstract: The present invention relates to the use of at least one partially crosslinked, solid, elastomeric organopolysiloxane associated with a fatty phase, in a composition containing a perfume, for the fixing and/or sustained release of this perfume. The composition may be a cosmetic and/or dermatological composition and can be, in particular, in the form of a gel. The invention also relates to a cosmetic process to perfume, care for and/or cleanse the skin and/or the hair, by applying to the skin and/or the hair a composition containing, in a physiologically acceptable medium, a perfume and a partially crosslinked, solid, elastomeric organopolysiloxane associated with a fatty phase.

Abstract: The present invention relates to perfume and fragrance pro-accords which are suitable for use in personal care and personal hygiene compositions as fragrance delivery systems. The pro-accords of the present invention slowly release fragrance raw materials upon contact with human skin thereby providing a prolonged fragrance benefit. The pro-accords serve as a means for delivering any fragrance raw material as well as other adjunct materials inter alia astringents, carriers, and diluents.

Abstract: Fragrant silanes having the formula:(R.sup.1 O).sub.a (R.sup.2 O).sub.b (R.sup.3 O).sub.c (R.sup.4).sub.d (R.sup.5).sub.e SiR.sup.6where R.sup.1, R.sup.2 and R.sup.3 are derived from the group of alcohols consisting of R.sup.1 OH, R.sup.2 OH and R.sup.3 OH wherein R.sup.1 OH, R.sup.2 OH and R.sup.3 OH are fragrant alcohols or alternatively R.sup.1, R.sup.2 and R.sup.3 are derived from the group of fragrant esters, ketones, or aldehydes having the structure:R.sup.7 --CH.sub.2 (C.dbd.O)--R.sup.8wherein the fragrant ester, ketone or aldehyde is capable of exhibiting the enol form of the carbonyl moiety under reaction conditions, with R.sup.4 and R.sup.5 selected from the group consisting of monovalent hydrocarbon radical having from one to forty carbon atoms and monovalent alkoxy radicals having from one to forty carbon atoms, R.sup.

Abstract: The present invention relates to perfume or fine fragrance compositions inter alia perfumes, colognes, eau de toilettes, and after shave lotions, comprising pro-accord compounds which release their fragrance raw material components on a delayed basis therefore providing sustained fragrance levels to the user. Typically the pro-accords are comprised of orthoesters, ketals, acetals, orthocarbonates which release two or more fragrance raw materials upon hydrolysis. The present invention also relates to an article of manufacture comprising a first pro-accord containing reservoir and a second fragrance raw material reservoir and a means for admixing and applying the perfume material.

Abstract: A fragrance is supplied in a gel form. The fragrance includes a fragrance oil, alcohol, and a sufficient amount of polymer to increase the viscosity of the oil and alcohol to the point where it will not readily pour from a container.

Abstract: Recombinant laminin B1k and fragments thereof.

Abstract: A composition comprising: an organic chemical having a chemical group having a dipole moment of at least about 1.5 Debyes and a chemical linker selected from the group consisting of carboxylic acids having 4 to 6 carbon atoms, an ethoxylated polyhydric alcohol, a polyvinyl pyrrolidone and a polyethylene glycol having a molecular weight of about 600 to about 10,000, wherein the molar ratio of organic chemical to chemical linker is about 4:1 to 1:4.

Abstract: The invention concerns a method of reducing the organoleptic effect of undesirable aldehydic components in a triglyceride or derivative thereof by addition of a reaction product of an amine and an organoleptically acceptable aldehyde. The triglyceride may be a food or food component such as an edible fat or a surface active agent such as a detergent. The reaction product may be incorporated in the perfume or flavour to be added to the triglyceride or derivative thereof without distorting their organoleptic effect.

Abstract: A non-alcoholic fragrance carrier with good fragrance solubility, product stability and clarity, and silky, non-tacky rub out when applied to the skin. Glycereth-7-triacetate is used for solubilization of fragrance oil into a non-alcohol water system. The ultimate fragrance carrier product is, e.g., a perfume or cologne composition, and contains a reduced overall surfactant level and reduced overall solids level. The composition thus minimizes the use of ingredients which tend to adversely affect evaporation rates, skin feel, rub-out time, and product turbidity.

Abstract: A composition comprising: an organic chemical Which has a chemical group having a dipole moment of at least about 1.5 and a chemical linker composition which is an ethoxylated glycerol type compound and, optionally, a compound selected from the group consisting of carboxylic acids having 4 to 6 carbon atoms, a polyvinyl pyrrolidone and a polyethylene glycol having a molecular weight of about 600 to about 10,000, wherein the molar ratio of organic chemical to the chemical linker composition is about 4:1 to 1:4.

Abstract: A cleaning/disinfecting concentrate is provided that includes a concentrate having, in admixture, 30-70% by volume of a detergent; 10-40% by volume of a non-emulsified fragrance; and 5-20% by volume of a preservative/disinfectant, wherein the ratio of detergent/surfactant to perfume/disinfectant is 0.75-5.0 by volume, as well as methods of making and using thereof.

Abstract: A liquid color/perfume concentrate comprising approximately by weight: 0.01% to 85% of a polymer bound water soluble azo dye and 99.95% to 15% of a perfume.

Abstract: Use of carnosine or derivatives or analogs thereof or of the combination of the active compounds a) carnosine or derivatives or analogs thereof and b) urocanic acid or derivatives or analogs thereof, or in each case mixtures of these compounds, if appropriate in each case in combination with an antioxidant or a plurality of antioxidants and if appropriate with a suitable carrier, for cosmetic and dermatological purposes, in particular for the prophylaxis and treatment of photosensitive skin, in particular photodermatoses, and preferably polymorphic photodermatosis.

Abstract: An aqueous self-supporting gel composition is provided, which consists essentially of:a) 1 to 20% of a fragrance material (preferably a fragrant oil),b) 2 to 10% of a carrageenan constituent,c) 0 to 2% of a preservative,d) 0 to 2% of a coloring agent, ande) 0 to 0.5% surfactant,the balance being water and all percentages being by weight of the composition.

Abstract: The invention relates to a use of a method of fixing and/or prolonging release of a perfume in a cosmetic and/or dermatological composition with a plant compound, said plant compound comprising a plant extract and may be a mixture of plant gum and of plant extract.