Abstract: Reaction mixtures that include exothermic generating particles having a water soluble coating encasing a portion of the particles, a volatile component and, optionally an aqueous solution, and a buffer. The reaction mixtures are especially suited to generate heat in a controllable manner. In one such controlled reaction, the reaction components are mixed together and the mixture increases in temperature to a Set Temperature within a predetermined time, and the mixture remains at the Set Temperature for a longer period of time. In this manner, volatile components can be controllably released to the surrounding environment. The volatile components can be, for example, a perfume, a fragrance, an insect repellent, a fumigant, a disinfectant, a bactericide, an insecticide, a pesticide, a germicide, an acaricide, a sterilizer, a deodorizer, a fogging agent and mixtures of these. Apparatuses and methods that use these reaction mixtures are also disclosed.

Abstract: The invention provides a method for improving release, on a surface, of a fragrance from an entrapment structure of at least one fragrance oil and at least one entrapment material. The method destabilizes the entrapment structure by providing at least one trigger molecule which preferentially associates with the entrapment material; and/or at least one release agent which at least partially disrupts the entrapment structure. The invention also provides a composition for improving release of a fragrance from a surface. The composition comprises at least one fragrance oil; at least one entrapment material, the at least one fragrance oil and the at least one entrapment material being capable, in use, of forming an entrapment structure on the surface.

Abstract: A composition for disinfecting contaminated drinking water. The composition can include a disinfecting agent for disinfecting or sanitizing the water and a masking agent for masking or minimizing undesired characteristics of the disinfecting agent, such as taste and odor. The disinfecting agent can be a halogen-based disinfecting agent, such as a chlorine-based disinfecting agent. The masking agent can be a chlorine-compatible masking agent or flavorant, such as a citrus fruit derived flavor. The composition can also include a substrate. The substrate can be a clay, zeolite, water-soluble carrier, water-insoluble carrier, or mixtures thereof. The flavorant can be loaded onto the substrate. The composition can include other components, such as a primary coagulant, a coagulant aid, a bridging flocculant, a polymeric material, an alkali agent, an autocatalytic oxidant, and mixtures thereof.

Abstract: A substantially odorless aromatic amine trapping agent is used in a composition including perfume for the purpose of enabling the perfume and trapping agent to react chemically together spontaneously and reversibly to form a reaction product form which the perfume can be released. In the reaction product, the perfume may be protected against degradation, premature evaporation etc., with the perfume being releasable from the reaction product. In contrast to a pro-perfume, the reaction product formed the present invention is not used by being included as such in a mixture of perfumes or perfumed product, but instead the perfume and trapping agent are included in a mixture of perfumes or perfumed product where they react spontaneously in situ to form a transient reaction product for subsequent release of the perfume. The invention also provides a perfume composition including the trapping agent.

Abstract: Processes for conjugating proteins with polyethylene glycol are disclosed. The disclosed processes provide modified proteins having little or no decrease in their activity and include the steps of deleting at least one amino acid residue on the protein, replacing the at least one amino acid residue with an amino acid residue that does not react with polyethylene glycol, and contacting the protein with polyethylene glycol under conditions sufficient to conjugate the polyethylene glycol to the protein. This advantageous retention of a desired protein activity is attributed to the availability of one or more protein binding sites which is unaltered in the conjugation process and thus remains free to interact with a binding partner ligand or cognate subsequent to the conjugation process.

Abstract: Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-related conditions are disclosed. The invention also relates to methods for identifying active agents useful in treating conditions related to cell death. The present inventors have found that different pathogens produce different cytotoxic factor(s) having anticancer activity. The substantially pure cytotoxic factors can be used in a method of treating an infectious disease or a cancer.

Abstract: The present invention relates to substituted cyclohexenes, to their use as well as to their preparation method. These compounds have powerful long lasting natural fruity grapefruit notes with minty and fresh green tonalities.

Abstract: Therapeutic uses of inhibitors of the Lymphotoxin Pathway to treat tumors, specifically to treat follicular lymphomas.

Abstract: This invention pertains to the discovery that the human NELL-1 gene induces or upregulates bone mineralization. The NELL-1 gene or gene product thus provides a convenient target for screening for modulators of bone mineralization. In addition, NELL-1 can be used to facilitate repair of bone fractures and/or to generally increase bone density.

Abstract: Pharmaceutical compositions useful for treating autoimmune diseases in a mammal comprising as an active ingredient a therapeutically effective amount of Copolymer 1, and microcrystalline cellulose are disclosed. Processes for the manufacture of such compositions are also disclosed.

Abstract: The present invention relates to novel heterocyclic pro-fragrances, preferably oxazolidines, tertahydro-1,3-oxazines, thiazolidines, or tetrahydro-1,3-thiazines, more preferably oxazolidines, or tertahydro-1,3-oxazines, most preferably oxazolidines, which are capable of sustained release of fragrance raw material ketones and aldehydes and to fragrance delivery systems which comprise said pro-fragrances.

Abstract: The present invention relates to a process for preparing or selecting compositions having a fragrance burst of at least 20% relative to a product before dilution as well as enhanced deposition. The composition is selected such that perfume and surfactant in said composition yields a calculated “Perfume Burst Index” (PBI) value of less than 3 as per algorithm defining the PBI.

Abstract: An antifungal fragrance composition containing as its active ingredients: (a) at least one type of fragrance component selected from the group consisting of an aliphatic or aromatic aldehyde having 5 to 16 carbon atoms and an aliphatic or aromatic alcohol having 5 to 16 carbon atoms, and (b) at least one type of compound different from component (a) and selected from the group consisting of an aliphatic or aromatic aldehyde, an aliphatic or aromatic alcohol, acetal and ester that produces synergistic antifungal effects in the presence of said fragrance component (a). The present antifungal fragrance composition demonstrates antifungal activity by adding a small amount of oils and fragrant chemical products that have a minimal effect on the scent of the fragrance composition.

Abstract: The present invention provides a fragrance precursor of formula I: that is capable of forming a fragrant ketone of formula II: and a fragrant lactone of formula III:

Abstract: Disclosed are compositions, processes and devices for use in HVAC systems to provide air freshening scent to air circulating in the system.

Abstract: A purified insulin-like growth factor binding protein (IGFBP) selected from the group consisting of insulin-like growth factor binding protein having an amino acid sequence that, preferably, is at least 70% homologous to the amino acid sequence of FIG. 1 and fragments thereof that are capable of binding to an antibody specific for the protein or to an insulin-like growth factor is described. This new IGFBP is designated herein as IGFBP-6. Recombinant DNA molecules encoding the binding proteins and subsequences thereof are also described along with recombinant microorganisms and cell lines containing the DNA molecules and methods for producing the binding proteins using recombinant hosts containing the relevant DNA molecules. Antibodies to the protein, useful in various diagnostic applications, are also described.

Abstract: Plastic additives which are useful as nucleating agents and which are especially useful for improving the optical properties of polymeric materials are provided. More particularly, this invention relates to certain alkyl (or alkoxy) substituted fluoro-benzylidene sorbitol acetals and polymer compositions thereof which may be utilized within, as merely examples, food or cosmetic containers and packaging. These inventive fluorinated and alkylated benzylidene sorbitol acetals are also useful as gelling agents for water and organic solvents, particularly those used in the preparation of antiperspirant gel sticks.

Abstract: The invention provides compositions comprising truncated tryptophanyl tRNA synthetase polypeptides useful for regulating angiogenesis, as well as nucleic acids encoding such truncated tRNA synthetase polypeptides. Methods of making and using such compositions are also disclosed.

Abstract: The present invention provides a gene Any-RF derived from an insect, having dormancy-control activity and biological cell-control function; a dormancy-control substance and a method for preparing the same; as well as a biological cell-control agent, which comprises, as an effective component, a physiologically active substance having a biological cell-control function and which never causes any antigen-antibody reaction in the living body. The gene encodes for a protein having an amino acid sequence specified as Sequence No. 1 in SEQUENCE LISTING: Asp-Ile-Leu-Arg-Gly, whose C-terminal is amidated and having a molecular weight of 570.959. The physiologically active substance comprising such a gene is a peptide, which can be isolated and purified by adding an acid-methanol aqueous solution to Antheraea yamamai, triturating the resulting mixture, centrifuging the same and then treating the resulting supernatant in an HPLC system.

Abstract: The invention relates to the discovery of a novel amino acid sequence motif, herein termed the RKIP motif, and to the family of proteins defined by the presence of that motif. Proteins comprising the RKIP motif modulate kinases involved in signal transduction pathways. The RKIP motif forms the basis for screening assays for the identification of agents useful for modulating signal transduction pathways subject to RKIP family mediated regulation, and for the diagnosis and treatment of disorders involving inappropriate activities of pathways subject to RKIP family medicated regulation.

Abstract: Non-aqueous based fragrance compositions containing a siloxane material are disclosed. The fragrance compositions are suitable for many applications including cosmetics, laundry care and personal care items. The fragrance compositions can also be used in air fresheners, particularly those air fresheners that contain heating elements.

Abstract: The present invention relates to fragrance delivery systems which comprise: A) from about 0.01% by weight of a pro-fragrance component which comprises pro-fragrances or pro-accords selected from at least two of the following: i) aldehyde and ketone releasing pro-fragrances, preferably an oxazolidine pro-fragrance; ii) ?-amino pro-fragrances; and iii) orthoester pro-accords; and B) the balance carries and others adjunct ingredients.

Abstract: Disclosed herein are pro-perfume compositions comprising the Michael Addition reaction product of a primary and/or secondary amine compound with an unsaturated ester, acid or nitrile perfume compound. Pro-perfumes made from this selected type of reaction product provide a desirable and prolonged odor benefit to surfaces, e.g., fabrics and hard surfaces, contacted therewith. Such pro-perfumes are also utilized in a wide variety of substrate-treating products and methods.

Abstract: The present invention relates to a process for preparing or selecting compositions having a fragrance burst of at least 20% relative to a product before dilution. The composition is selected such that perfume and surfactant in said composition yields a calculated “Perfume Burst Index” (PBI) value of greater than 3 as per algorithm defining the PBI.

Abstract: Methods for treating endocrine disorders and for inhibiting gametogenesis by intracranial administration to a human patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin type A.

Abstract: A peptide referred to as cadherin-derived growth factor (CDGF) the sequence of which corresponds to a partial sequence of a pre-pro-cadherin, said pre-pro-cadherin comprising the domains signal sequence, pro sequence cadherin repeats, transmembrane region and intracellular domain, characterized in that the sequence of said peptide comprises the pro sequence, that at least one of the other domains of the pre-pro-cadherin is lacking, and that said peptide has cell-proliferative, cell-protective and/or cell-differential properties.

Abstract: Non-aqueous based fragrance compositions containing a siloxane material are disclosed. The fragrance compositions are suitable for many applications including cosmetics, laundry care and personal care items. The fragrance compositions can also be used in air fresheners, particularly those air fresheners that contain heating elements.

Abstract: The present invention relates to compositions having a fragrance burst of at least 20% relative to a product before dilution. The composition is selected such that perfume and surfactant in said composition yields a calculated “Perfume Burst Index” (PBI) value of less than 3 as per algorithm defining the PBI.

Abstract: Benefit agent delivery systems, compositions incorporating such benefit agent delivery systems, and methods for making the delivery system in the compositions are provided. The benefit agent delivery systems of the present invention employ polymer particles having affinities for selected benefit agents, such as perfume, to form the polymeric assisted benefit agent delivery systems, which can effectively deposit benefit agents onto, onto the surface of a substrate, e.g., fabrics being laundered, hard surfaces, hair, skin or nails.

Abstract: The present invention provides a carrier for the delivery of molecules with biological function into both cellular and nuclear compartments. The carrier disclosed is heat shock protein 70 (“Hsp70”), or a fragment of Hsp70 as described herein, as a vehicle for directed, noninvasive delivery of molecules, such as proteins, peptides, or DNA, that may modulate cellular activity. The present invention also encompasses the use of Hsp70, or a fragment thereof, to modulate cellular activity, preferably to modulate nuclear activity in a cell or cells.

Abstract: Plastic additives which are useful as nucleating agents and which are especially useful for improving the optical properties of polymeric materials are provided. More particularly, this invention relates to certain alkyl (or alkoxy) substituted fluoro-benzylidene sorbitol acetals and polymer compositions thereof which may be utilized within, as merely examples, food or cosmetic containers and packaging. These inventive fluorinated and alkylated benzylidene sorbitol acetals are also useful as gelling agents for water and organic solvents, particularly those used in the preparation of antiperspirant gel sticks.

Abstract: The present invention relates to the therapeutic use of particles which are efficiently removed from the circulation, the said particles display pathogen-specific binding moieties to chaperone the clearance of potentially injurious substances from a vertebrate's circulation. The invention is also drawn to methods for treating, diagnosing, or screening for diseases and disorders associated with the presence of the pathogens. The present invention also relates to pharmaceutical compositions and diagnostic kits containing the therapeutic particle which displays the pathogen binding moiety of the invention.

Abstract: The present invention relates to a process for reducing fragrance loss in a substrate. This process includes preparing a protected fragrance matrix that contains a perfume, an optional fixative and a solid absorbent. The process further includes combining a substrate conditioner with the fragrance matrix and a substrate. Products, especially fabric softener sheets, made from these processes are also provided.

Abstract: Non-aqueous based fragrance compositions containing a siloxane material are disclosed. The fragrance compositions are suitable for many applications including cosmetics, laundry care and personal care items. The fragrance compositions can also be used in air fresheners, particularly those air fresheners that contain heating elements.

Abstract: Non-aqueous based fragrance compositions containing a siloxane material are disclosed. The fragrance compositions are suitable for many applications including cosmetics, laundry care and personal care items. The fragrance compositions can also be used in air fresheners, particularly those air fresheners that contain heating elements.

Abstract: The present invention relates to a base for an alcohol-free, non-fatty, non-sticky perfumed aqueous cosmetic composition, including an aqueous medium, one or more non-ionic surfactants and a solvent, this base being characterized in that said solvent is isoprene glycol.

Abstract: The invention relates to an alcoholic base mixture that contains extracts from fruit and dairy products. The mixture consists of the extract form pineapple fruit obtained by alcoholic extraction in the temperature range of from 10 to 30° C. and of the extract from yogurt obtained by alcoholic extraction in the temperature range of 10 to 30° C. The ratio of pineapple extract to yogurt extract ranges from 20:80 to 80:20. Used as a cosmetic perfumed preparation, for example as a perfume, the base mixture may generate a feeling of happiness by increasing the serotonin level, which effect is intensified by an additional bright yellow coloration.

Abstract: The present invention relates to a process for preparing or selecting compositions having a fragrance burst of at least 20% relative to a product before dilution as well as enhanced deposition. The composition is selected such that perfume and surfactant in said composition yields a calculated “Perfume Burst Index” (PBI) value of less than 3 as per algorithm defining the PBI.

Abstract: The present invention relates to a process for preparing or selecting compositions having a fragrance burst of at least 20% relative to a product before dilution. The composition is selected such that perfume and surfactant in said composition yields a calculated “Perfume Burst Index” (PBI) value of less than 3 as per algorithm defining the PBI.

Abstract: The present invention relates to compositions having a fragrance burst of at least 20% relative to a product before dilution. The composition is selected such that perfume and surfactant in said composition yields a calculated “Perfume Burst Index” (PBI) value of less than 3 as per algorithm defining the PBI.

Abstract: The present invention relates to sustained release fragrance accords wherein the initial fragrance release or bouquet is not distorted by the presence of an unbalanced accord. The systems of the present invention comprise: a) a pro-fragrance component; and b) a free fragrance component. The present invention further relates to compositions comprising the fragrance raw materials systems and processes for preparing said systems.

Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.

Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.

Abstract: The present invention relates to a dimeric urethane compounds derived from monohydric alcohols, generally fatty alcohols, and a diisocyanate according to the following reaction scheme: wherein R1 is selected from the group of saturated, unsaturated or halogen substituted linear, cyclic or branch-chained hydrocarbons and R2 is a linear, cyclic or branch-chained alkyl or aminoalkyl group ranging from two to 200 carbon atoms, preferably two to 50 carbons, more preferably 6 to 36 carbons, even 6 to 24 carbons, said urethane compound being substantially free from terminal hydroxyl groups.

Abstract: This invention provides a method for stabilization of a fragrance ingredient in a salt mixture, comprising the steps of encapsulating the fragrance ingredient in a first encapsulating material, which is water soluble and insoluble in a volatile organic solvent, to form a first encapsulated material; encapsulating a salt in a second encapsulating material which is dissolved in a volatile organic solvent to form a second encapsulated material, and then partially drying the second encapsulated material; mixing the first encapsulated material with the second encapsulated material before the volatile, organic solvent completely evaporates from the second encapsulated material; and removing remaining volatile organic solvent to form a free flowing salt and fragrance containing powder.

Abstract: The present invention relates to fragrance delivery systems which comprise: a) one or more pro-fragrances having formula (I) wherein G1 and G2 are methyl, or a cyclic hydrocarbyl unit derived from the isomers of ionone and/or damascone; R and R1 are each independently C1-C22 substituted or unsubstituted, branched or unbranched alkyl, C2-C22 substituted or unsubstituted, branched or unbranched alkenyl, C2-C20 substituted or unsubstituted, branched or unbranched hydroxyalkyl, C7-C20 substituted or unsubstituted alkylenearyl, C3-C20 substituted or unsubstituted cycloalkyl, alkyleneoxy, C6-C20 aryl, C5-C20 heteroaryl comprising one or more heteroatoms selected from the group consisting of nitrogen, oxygen, sulfur, and mixtures thereof; two of the units Y1, Y2, R or R1 can be taken together to form one or more aromatic or non-aromatic, heterocyclic or non-heterocyclic, single rings, fused rings, bicyclo rings, spiroannulated rings, or mixtures thereof, said rings comprising from 3 to 20 carbon atoms and one or mor

Abstract: The present invention relates to cyclic pro-perfumes comprising a moiety derived from a fragrance raw material alcohol. Such cyclic perfumes may contain dioxolane and glucosyl orthesters that are suitable for use in delivering enhanced fragrance longevity to human skin.

Abstract: The present invention relates to compositions and methods for controlling malodor on surfaces and particularly tobacco smoke on and in fabrics. The compositions of the present invention comprise aldehyde-containing fragrance components, nonionic surfactant and an aqueous vehicle. Optionally, additional solubilizers, odor control components and preservatives can be included. The compositions of the invention can be prepared as stable, gel-free, clear concentrates and diluted for use. If prepared as a concentrate, the concentrate is diluted with water to a ready to use concentration and sprayed on the surface to be deodorized. Generally the malodors are significantly reduced in about 5 minutes or less. The compositions of the invention are particularly effective against smoke odors and demonstrate the ability to reduce these odors for relatively long periods of time. Selected amine disinfectant compounds can be included in the compositions to provide disinfecting properties.

Abstract: The invention relates to an alcohol-free translucent perfuming composition in the form of a low viscosity, vaporizable oil-in-water emulsion containing at least a perfuming ingredient, a surfactant system having a hydrophilic-lipophilic ratio not less than 10 and water. The composition has been optimized so as to include significant amounts of perfume. The emulsion is also characterized by the variation of the average size of its drops during the month following its formulation, at a temperature of 45° C. and ranging between 0.1 and 30 nm.

Abstract: Cellophane wrapping (CW) of hamster pancreas induces proliferation of duct epithelial cells followed by endocrine cell differentiation and islet neogenesis. Using the mRNA differential display technique a cDNA clone expressed in cellophane wrapped but not in control pancreata was identified. Using this cDNA as a probe, a cDNA library was screened and a gene not previously described was identified and named INGAP.