1-thia-4-aza-bicyclo (3.2.0) Heptane Ring Containing (including Dehydrogenated) (e.g., Penicillins, Etc.) Patents (Class 514/192)

Spiro or additional polycyclo ring system (Class 514/193)

6,6-di-substituted (Class 514/194)

3-position substituent contains -cooc- group (Class 514/195)

6-position substituent contains hetero ring (Class 514/196)

6-position substituent contains carbocyclic ring (Class 514/197)

Methods and reagents for the treatment of multiple sclerosis

Patent number: 6890526

Abstract: The invention features methods and reagents for the diagnosis, monitoring, and treatment of multiple sclerosis. The invention is based in part on the discovery that Chlamydia is present in patients with multiple sclerosis, and that anti-chlamydial agents improve or sustain neurological function in these patients.

Type: Grant

Filed: April 17, 2003

Date of Patent: May 10, 2005

Assignee: Vanderbilt University

Inventors: Charles W. Stratton, William M. Mitchell, Subramaniam Sriram
Diagnosis and management of infection caused by chlamydia

Patent number: 6884784

Abstract: The present invention provides a unique approach for the diagnosis and management of infections by Chlamydia species, particularly C. pneumoniae. The invention is based, in part, upon the discovery that a combination of agents directed toward the various stages of the chlamydial life cycle is effective in substantially reducing infection. Products comprising combination of antichlamydial agents, novel compositions and pharmaceutical packs are also described.

Type: Grant

Filed: March 19, 2002

Date of Patent: April 26, 2005

Assignee: Vanderbilt University

Inventors: William M. Mitchell, Charles W. Stratton
Method of healing skin wounds in mammals and a composition therefor

Publication number: 20040265396

Abstract: This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or wound healing composition alone. In one embodiment, the wound healing composition comprises (a) zinc oxide; (b) calcium channel blocker, and (c) fat-soluble vitamins admixed with antibacterial and antifungal agents. The therapeutic antibacterial/antifungal-wound healing compositions may be utilized in a wide variety of pharmaceutical products and administered orally or topically.

Type: Application

Filed: September 30, 2003

Publication date: December 30, 2004

Inventor: Mickey L. Peshoff
Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate

Publication number: 20040265379

Abstract: Bacterial infections may be treated using a high dosage regimen of amoxycillin and potassium clavulanate.

Type: Application

Filed: June 8, 2004

Publication date: December 30, 2004

Applicant: Beecham Pharmaceuticals ( Pte) Limited

Inventors: Creighton P. Conley, John A. Roush, Kevin H. Storm
Pharmaceutical composition and method for treating

Publication number: 20040247679

Abstract: Embodiments of the invention generally provide pharmaceutical drug compositions, methods of preparing oral drug compositions, such as extended release dosage compositions, and methods for treating infection. More particularly, the invention relates to formulations containing a drug and a carrier material. In one aspect, the invention provides a pharmaceutical formulation including a therapeutically active agent, from about 0.1% to about 4.9% by weight of a pharmaceutically acceptable polymer, and from about 0.1% to about 30% by weight of a pharmaceutically acceptable acid, wherein the pharmaceutical composition have a zero order release profile of the therapeutically active agent. In another aspect, the invention provides methods for preparing and administering a pharmaceutical antibiotic composition in oral dosage form, such as a tablet.

Type: Application

Filed: June 3, 2003

Publication date: December 9, 2004

Applicant: BioKey, Inc.

Inventors: Jenny Li-Ying Lin, David Wong, San-Laung Chow
Compositions and methods of treatment comprising amoxicillin and potassium clavulanate with xanthan

Publication number: 20040241227

Abstract: Bacterial infections may be treated using a high dosage regimen of amoxicillin and potassium clavulanate. Preferably, the dosage is provided by a bilayer tablet.

Type: Application

Filed: June 17, 2004

Publication date: December 2, 2004

Applicant: Beecham Pharmaceutials (Pte) Limited

Inventors: Kevin H. Storm, Creighton P. Conley, John A. Roush
Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate

Publication number: 20040242555

Abstract: Bacterial infections may be treated using a high dosage regimen of amoxycillin and potassium clavulanate.

Type: Application

Filed: June 8, 2004

Publication date: December 2, 2004

Applicant: Beecham Pharmaceuticals (Pte) Limited

Inventors: Creighton P. Conley, John A. Roush, Kevin H. Storm
Neurotherapeutic composition and method

Publication number: 20040229857

Abstract: Administration of &bgr;-Lactam compounds, including &bgr;-lactam antibiotics and &bgr;-lactamase inhibitors provides significant neurotropic effects in warm-blooded vertebrates evidenced inter alia by anxiolytic and anti-aggressive behavior modification and enhanced cognition. Therapeutic methods for using such compounds and their pharmaceutical formulations are described.

Type: Application

Filed: September 9, 2003

Publication date: November 18, 2004

Inventor: Gary A. Koppel
Dispersible pharmaceutical compositions

Publication number: 20040214752

Abstract: A pharmaceutical composition is provided comprising a vehicle that comprises (a) an amphipathic oil that is water dispersible and ethanol insoluble, (b) microcrystalline wax, and (c) a pharmaceutically acceptable non-aqueous carrier; and having an antibacterial substance in an antibacterially effective amount stably dispersed in the vehicle. The composition is suitable for administration by intramammary infusion to a milk producing animal for treatment and/or prevention of mastitis or other diseases of the udder, as well as for otic administration for treatment and/or prevention of an ear infection.

Type: Application

Filed: October 17, 2003

Publication date: October 28, 2004

Inventors: Nancy Jean Britten, Niki Ann Waldron, John W. Burns
Dispersible pharmaceutical composition for treatment of mastitis and otic disorders

Publication number: 20040214753

Abstract: A method is provided for treatment of an infective condition in a fluid-containing organ having a natural exterior orifice, such as the udder of a milk producing animal or an ear. The method comprises administering an antibacterial agent to the organ via the exterior orifice and administering in combination therapy with the antibacterial agent a second agent that is an anti-inflammatory agent, an analgesic and/or an antipyretic. The antibacterial agent and, optionally, the second agent, are administered as a pharmaceutical composition further comprising a vehicle that comprises an amphipathic oil that is water dispersible and ethanol insoluble, microcrystalline wax and a pharmaceutically acceptable non-aqueous carrier. Also provided is such a composition comprising the antibacterial agent and the second agent.

Type: Application

Filed: March 5, 2004

Publication date: October 28, 2004

Inventors: Nancy Jean Britten, Niki Ann Waldron, Jeffrey L. Watts, John Walter Hallberg, John W. Burns
Taste masked liquid pharmaceutical compositions

Patent number: 6806256

Abstract: This invention is directed to a taste masked liquid pharmaceutical composition comprising a pharmaceutically active agent and a taste masking composition. In particular, the taste masking composition comprises a taste masking effective amount of an artificial sweetener.

Type: Grant

Filed: February 26, 2002

Date of Patent: October 19, 2004

Assignee: Ortho -McNeil Pharmaceutical, Inc.

Inventors: Stephen A. Ulrich, Karen R. Zimm, Marc Karel Jozef Francois, Willy Maria Albert Carlo Dries
Compositions containing pipercillin and tazobactam sodium useful for injection

Publication number: 20040204372

Abstract: The invention pertains to pharmaceutical compositions of Zosyn® in the presence of a buffer, preferably citrate, a particulate formation inhibitor, preferably EDTA optionally an aminoglycoside which when frozen and thawed or lyophilized and reconstituted reform a solution which has decreased particulate formation.

Type: Application

Filed: April 14, 2003

Publication date: October 14, 2004

Applicant: Wyeth Holdings Corporation

Inventors: Jonathan Marc Cohen, Syed M. Shah, Christian Luther Ofslager, Mahdi Fawzi
Process for preparing pharmaceutical formulations using supercritical fluids

Publication number: 20040202681

Abstract: The invention is directed to a process for preparing a pharmaceutical formulation containing two or more active pharmaceutical ingredients comprising: (a) contacting two or more active pharmaceutical ingredients with a supercritical fluid to form a supercritical fluid solution; and (b) separating the active ingredients from the supercritical solution to yield a powder precipitate. Preferably, the pharmaceutical formulation prepared according to the invention contains a combination of two anti-infective agents or two anticancer agents. The invention is further directed to a process for preparing a pharmaceutical formulation containing two or more active pharmaceutical ingredients comprising: (a) combining two or more active ingredients with a cosolvent to form a solution; (b) contacting the solution with a supercritical fluid; and (c) recovering the precipitate in a powder form.

Type: Application

Filed: December 19, 2003

Publication date: October 14, 2004

Applicants: BAXTER INTERNATIONAL, INC., THAR TECHNOLOGIES, INC.

Inventors: Satish Pejaver, Navneet Puri, Poongunran Muthukumaran, Lalit Chordia
Pharmaceutical compositions releasing their active agents from a buccal or sublingual location to overcome an absorption window problem

Publication number: 20040202693

Abstract: Disclosed are controlled release dosage forms of pharmaceutical or nutritional agents that are intended for retention in a buccal or sublingual location for administration. The dosage forms are particularly useful for the sustained release administration of drugs that have a limited window of absorption in the gastrointestinal tract and that are minimally, if at all, absorbed mucosally.

Type: Application

Filed: April 13, 2004

Publication date: October 14, 2004

Inventor: Rong-Kun Chang
Process for preparing pharmaceutical formulations using supercritical fluids

Publication number: 20040197412

Abstract: The invention is directed to a process for preparing a pharmaceutical formulation containing two or more active pharmaceutical ingredients comprising: (a) combining two or more active pharmaceutical ingredients with a supercritical fluid to form a supercritical fluid solution; and (b) separating the active ingredients from the supercritical solution to yield a dry powder precipitate. Preferably, the pharmaceutical formulation prepared according to the invention contains a combination of two anti-infective agents. The invention is further directed to a process for preparing a pharmaceutical formulation containing two or more active pharmaceutical ingredients comprising: (a) combining two or more active ingredients with a cosolvent to form a solution; (b) mixing the solution with a supercritical fluid; and (c) recovering the precipitate in a dry powder form.

Type: Application

Filed: December 19, 2003

Publication date: October 7, 2004

Applicant: BAXTER INTERNATIONAL, INC.

Inventors: Satish Pejaver, Navneet Puri
Novel therapeutic targets for the treatment of mycobacterial infections and compounds useful therefor

Publication number: 20040171603

Abstract: Described herein is the discovery that certain mycobacterial serine/threonine protein kinases, particularly protein kinase G (PknG), are effective therapeutic targets for the treatment of mycobacterial infections. Furthermore, the present application refers to the use of mycobacterial serine/threonine protein kinases for developing methods for detection and determination of these kinases for recognizing and monitoring diseases and for controlling therapy of diseases.

Type: Application

Filed: November 18, 2003

Publication date: September 2, 2004

Inventors: Janos Pato, Gyorgy Keri, Laszlo Orfi, Frigyes Waczek, Zoltan Horvath, Peter Banhegyi, Istavan Szabadkai, Jeno Marosfalvi, Balint Hegymegi-Barakonyi, Zsolt Szekelyhidi, Zoltan Greff, Axel Choidas, Gerald Bacher, Andrea Missio, Anil Koul
Amoxycillin pellets

Publication number: 20040170691

Abstract: Pelletised amoxycillin trihydrate for improved processability.

Type: Application

Filed: April 16, 2004

Publication date: September 2, 2004

Inventor: Francis Walter Grimmett
Method for treating a mental disorder

Publication number: 20040167062

Abstract: A method of treating an individual exhibiting at least one symptom of a mental disorder is provided which comprises administering to the individual an antimicrobial composition in an amount effective to inhibit or eliminate the at least one symptom of the disorder. This invention also pertains to a method of treating an individual exhibiting at least one symptom of a mental disorder by administering a probiotic mixture to replenish gastrointestinal microbes.

Type: Application

Filed: December 19, 2003

Publication date: August 26, 2004

Inventor: Ellen R. Bolte
Combination of antimicrobial agents and bacterial interference to coat medical devices

Publication number: 20040166094

Abstract: This invention relates to a method for coating a medical device comprising the steps of applying to at least a portion of the surface of said medical device, an antimicrobial coating layer and a non-pathogenic bacterial coating layer, wherein the antimicrobial and non-pathogenic bacterial coating layers inhibit the growth of pathogenic bacterial and fungal organisms. The non-pathogenic bacterium used in the bacterial coating layer is resistant to the antimicrobial agent. Furthermore, the non-pathogenic bacterium layer includes at least one of the following: viable whole cells, non-viable whole cells, or cellular structures or extracts. The antimicrobial agent and non-pathogenic bacterium are used to develop a kit comprising these compositions in one container or in separate containers. The kit is used to coat a catheter prior to implantation in a mammal.

Type: Application

Filed: February 26, 2004

Publication date: August 26, 2004

Inventors: Rabih O. Darouiche, Richard Hull
Anhydrous crystal of beta-lactam compound and method for preparation thereof

Publication number: 20040162277

Abstract: The present invention provides anhydrous crystals of &bgr;-lactam compound represented by the formula: 1

Type: Application

Filed: April 5, 2004

Publication date: August 19, 2004

Inventors: Akihiro Shimbayashi, Shigetoshi Yaguchi
Treating mouth ulcers with patches to speed healing and relieve pain

Publication number: 20040156930

Abstract: A method for treating mouth ulcers (canker sores/aphthous ulcers) with oral patches to speed healing and relieve pain. If certain medications are applied to a mouth ulcer using an adhesive oral patch that delivers the medication for at least 30 minutes and the patches are used for at least two or more hours per day, the method reduces the healing times from typically 10-14 days to typically 2 days. The method can be used with various antimicrobials that speed the healing of canker sores, including penicillin and amoxicillin. The method can also be used with amlexanox and licorice (glycyrrhiza) extract which work by an unknown method. When used with licorice extract, the method also quickly reduces canker sore pain and, if used before commencing a meal, reduces pain during the meal. A dissolving patch with licorice extract is disclosed.

Type: Application

Filed: February 4, 2004

Publication date: August 12, 2004

Inventor: Jeffrey T. Haley
Antibacterial composition for topical administration containing antibiotic

Publication number: 20040151743

Abstract: The present invention provides a safe antibacterial composition for topical administration which stably contains a penem antibiotic having a broad-spectrum and potent antibacterial activity while otherwise being chemically susceptible to hydrolysis, oxidation, photoisomerization or the like. The compositions of the present invention comprise an antibacterial composition for topical administration comprising a penem antibiotic or a pharmaceutically acceptable salt thereof in a non-aqueous base.

Type: Application

Filed: January 16, 2004

Publication date: August 5, 2004

Applicant: Daiichi Suntory Parma Co., Ltd.

Inventors: Masaaki Nomura, Hiromi Sumikawa, Osamu Sugita
Methods and reagents for preventing bacteremias

Publication number: 20040147441

Abstract: The present invention provides methods and compositions useful for preventing bacteremia by decolonizing the intestinal tract of a patient. Although the present invention is useful for preventing bacteremia by any Gram-positive bacteria, it is particularly useful against antibiotic-resistant bacteria, such as vancomycin-resistant Enterococcus (VRE), methicillin-resistant Staphylococcus aureus (MRSA), glycopeptide intermediary susceptible Staphylococcus aureus (GISA), and penicillin-resistant Streptococcus pneumoniae (PRSP). Decolonization therapy using the methods and compositions of this invention are also useful for preventing a Gram-negative bacteremia.

Type: Application

Filed: August 25, 2003

Publication date: July 29, 2004

Inventors: Timothy S. Leach, Jeffrey Packman
Death domain containing receptor 5

Publication number: 20040141952

Abstract: The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity.

Type: Application

Filed: February 10, 2004

Publication date: July 22, 2004

Applicant: Human Genome Sciences, Inc.

Inventors: Jian Ni, Reiner L. Gentz, Guo-Liang Yu, Craig A. Rosen
Sustained release of antiinfectives

Publication number: 20040142026

Abstract: Provided, among other things, is a method of treating or ameliorating pulmonary infection in a cystic fibrosis patient comprising pulmonary administration of an effective amount of a liposomal/complexed antiinfective to the patient, wherein the (i) administrated amount is 50% or less of the comparative free drug amount, or (ii) the dosing is once a day or less, or (iii) both.

Type: Application

Filed: October 29, 2003

Publication date: July 22, 2004

Applicant: Transave, Inc.

Inventors: Lawrence T. Boni, Brian S. Miller
Salinosporamides and methods for use thereof

Publication number: 20040138196

Abstract: The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian cells. The CNB392 and CNB476 strains lie within the family Micromonosporaceae, and the generic epithet Salinospora has been proposed for this obligate marine group. The reaction products produced by this strain are classified as salinosporamides, and are particularly advantageous in treating neoplastic disorders due to their low molecular weight, low IC50 values, high pharmaceutical potency, and selectivity for cancer cells over fungi.

Type: Application

Filed: June 20, 2003

Publication date: July 15, 2004

Inventors: William Fenical, Paul Jensen, Tracy Mincer, Robert H.R. Feling
Catecholate beta-lactam conjugates, method for producing the same and the use thereof

Publication number: 20040132707

Abstract: Catacholate beta-lactam conjugates, methods for producing these compounds, and compositions containing these compounds useful as siderophores or for treatment of bacterial infections are provided.

Type: Application

Filed: August 29, 2003

Publication date: July 8, 2004

Applicant: Gruenenthal GmbH

Inventors: Lothar Heinisch, Steffen Wittmann, Ina Scherlitz-Hofmann, Thomas Stoiber, Albrecht Berg, Ute Moellmann
Process for preparing 6-alkylidene penem derivatives

Publication number: 20040132708

Abstract: The present invention provides a process of making compounds of formula I, which are useful for the treatment of bacterial infection or disease.

Type: Application

Filed: October 24, 2003

Publication date: July 8, 2004

Applicant: Wyeth

Inventors: Takao Abe, Hiroshi Matsunaga, Ado Mihira, Chisato Sato, Hideki Ushirogochi, Koichi Sato, Tsuyoshi Takasaki, Aranapakam Mudumbai Venkatesan, Tarek Suhayl Mansour
Novel formulation

Publication number: 20040126429

Abstract: Bacterial infections may be treated using a high dosage regimen of amoxycillin and potassium clavulanate.

Type: Application

Filed: December 10, 2003

Publication date: July 1, 2004

Applicant: Beecham Pharmaceuticals (Pte) Limited

Inventors: Kevin H. Storm, Creighton P. Conley, John A. Roush
Diagnosis and management of infection caused by Chlamydia

Patent number: 6756369

Abstract: The present invention provides a unique approach for the diagnosis and management of infections by Chlamydia species, particularly C. pneumoniae. The invention is based, in part, upon the discovery that a combination of agents directed toward the various stages of the chlamydial life cycle is effective in substantially reducing infection. Products comprising combination of antichlamydial agents, novel compositions and pharmaceutical packs are also described.

Type: Grant

Filed: March 19, 2002

Date of Patent: June 29, 2004

Assignee: Vanderbilt University

Inventors: William M. Mitchell, Charles W. Stratton
Novel formulation

Publication number: 20040121013

Abstract: Formulations are provided herein which allow for a once daily dosing regimen for amoxicillin and clavulanic acid.

Type: Application

Filed: December 10, 2003

Publication date: June 24, 2004

Applicant: Beecham Pharmaceuticals (Pte) Limited

Inventors: Kevin H. Storm, Creighton P. Conley, John A. Roush
Beta-lactamase inhibitor prodrug

Publication number: 20040110740

Abstract: Prodrugs of 6-&bgr;-hydroxymethylpenicillanic acid sulfone having the structure 1

Type: Application

Filed: August 25, 2003

Publication date: June 10, 2004

Applicant: Pfizer Inc

Inventors: Anthony Marfat, Dale G. McLeod
Methods for preventing and treating microbial infections by modulating transcription factors

Publication number: 20040106553

Abstract: The current invention is based, inter alia, on the finding that the transcription factor MarA, and homologues of MarA, e.g., Rob and SoxS, are virulence factors. Accordingly, the invention discloses methods for screening compounds for their ability to modulate these virulence factors. The invention further describes methods for treating and preventing bacterial infections by modulating the expression and/or activity of transcription factors. In addition, the invention provides a method for identifying other virulence factors.

Type: Application

Filed: June 24, 2003

Publication date: June 3, 2004

Inventors: Michael N. Alekshun, Stuart B. Levy
Polycyclic quinone and ionophore composition for the synergistic reduction of methane formation in ruminant animals

Patent number: 6743440

Abstract: A composition, preferably used to reduce methane formation in a ruminant, wherein the composition is a combination of a polycyclic quinone compound and an ionophore compound.

Type: Grant

Filed: October 10, 2000

Date of Patent: June 1, 2004

Assignee: Arkion Life Sciences LLC

Inventor: Kenneth E. Ballinger, Jr.
Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment and management of macular degeneration

Publication number: 20040091454

Abstract: Methods of treating, preventing and/or managing macular degeneration are disclosed. Specific embodiments encompass the administration of a selective cytokine inhibitory drug, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent and/or surgery. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

Type: Application

Filed: October 30, 2003

Publication date: May 13, 2004

Inventor: Jerome B. Zeldis
Methods of using and compositions comprising immunomodulatory compounds for treatment and management of macular degeneration

Publication number: 20040091455

Abstract: Methods of treating, preventing and/or managing macular degeneration are disclosed. Specific embodiments encompass the administration of an immunomodulatory compound, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent and/or surgery. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

Type: Application

Filed: October 30, 2003

Publication date: May 13, 2004

Inventor: Jerome B. Zeldis
Antibiotic composition and method

Publication number: 20040072815

Abstract: Novel antibiotic compositions are described. &bgr;-lactam antibiotics are used in combination with a non-&bgr;-lactam inhibitor of NAALADase, the inhibitor in an amount effective to inhibit &bgr;-lactamase activity. The antibiotic compositions can be administered to treat infections caused by &bgr;-lactamase-producing bacterial strains.

Type: Application

Filed: August 5, 2003

Publication date: April 15, 2004

Inventor: Gary A. Koppel
Novel method of treatment

Publication number: 20040067925

Abstract: Bacterial infections may be treated using a high dosage regimen of amoxycillin. Preferably, the dosage is provided by a bilayer tablet.

Type: Application

Filed: October 7, 2003

Publication date: April 8, 2004

Applicant: Beecham Pharmaceuticals (Pte) Limited

Inventors: Creighton P. Conley, John A. Roush, Kevin H. Storm
Hemostatic compositions and methods

Publication number: 20040062790

Abstract: The present invention provides methods and compositions involving resorbable hemostatic agents that have the essential absence of microfibrillar collagen. Resorbable hemostatic agents of the present invention comprise polyethylene glycol, which controls bleeding in tissue and does not delay or interfere with healing. The resorbable hemostatic agents of the present invention are biodegradable and biocompatible agents that effectively control bleeding in bone and other tissue without interfering with the subsequent healing of the tissue.

Type: Application

Filed: September 26, 2002

Publication date: April 1, 2004

Inventors: Barry E. Constantine, Nels J. Lauritzen
Wound healing compound

Publication number: 20040062817

Abstract: This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprise a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or wound healing composition alone. In one embodiment, the wound healing composition comprises (a) zinc oxide and (b) fat-soluble vitamins. The therapeutic antibacterial/antifungal-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the antibacterial/antifungal-wound healing compositions and the pharmaceutical products in which the therapeutic compositions may be used.

Type: Application

Filed: September 30, 2003

Publication date: April 1, 2004

Inventor: Mickey L. Peshoff
Method of testing gastrointestinal diseases associated with species of genus clostridium

Publication number: 20040062757

Abstract: The invention includes a method of treating gastrointestinal diseases associated with species of genus Clostridium such as clostridium deficit in human patients with gastrointestinal disorders having an etiological component such as a microbial agent producing a toxin where treated with an antimicrobial composition an amount effective to inhibit or eliminate the microbial agent. The antimicrobial composition in a form of probiotic mixture can be administrated alone or in combination with an antimicrobial agent, such as a bacteriophage which is specific for a bacterium producing toxin or antibiotics which are then used to eliminate or inhibit the clostridial species overgrown in a patient's gastrointestinal tract. Disorders that can be treated by the method of the invention include diarrhea or inflammatory bowel diseases such as colitis or Crohn's disease.

Type: Application

Filed: October 7, 2003

Publication date: April 1, 2004

Inventor: Sydney M. Finegold
Process for preparing 6-alkylidene penem derivatives

Publication number: 20040053913

Abstract: The present invention provides a process of making compounds of formula I, which are useful for the treatment of bacterial infection or disease.

Type: Application

Filed: May 1, 2003

Publication date: March 18, 2004

Applicant: Wyeth

Inventors: Takao Abe, Hiroshi Matsunaga, Ado Mihira, Chisato Sato, Hideki Ushirogochi, Koichi Sato, Tsuyoshi Takasaki, Aranapakam Mudumbai Venkatesan, Tarek Suhayl Mansour
Bioavailability / bioefficacy enhancing activity of cuminum cyminum and extracts and fractions thereof

Publication number: 20040052873

Abstract: The present invention relates to a bioenhancing/bioavailability-facilitating composition comprising:

Type: Application

Filed: March 11, 2003

Publication date: March 18, 2004

Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

Inventors: Ghulam Nabi Qazi, Kasturi Lal Bedi, Rakesh Kamal Johri, Manoj Kumar Tickoo, Ashok Kumar Tickoo, Subhash Chander Sharma, Sheikh Tasaduq Abdullah, Om Parkash Suri, Bishan Datt Gupta, Krishan Avtar Suri, Naresh Kumar Satti, Ravi Kant Khajuria, Surjit Singh, Anamika Khajuria, Bal Krishan Kapahi
Process for the preparation of a beta -lactam nucleus and the application thereof

Publication number: 20040053912

Abstract: The invention relates to a process for the preparation of an aqueous solution or suspension of a &bgr;-lactam nucleus and application thereof. The aqueous solution or suspension of the &bgr;-lactam nucleus is prepared by process wherein an enzymatic deacylation of a &bgr;-lactam compound, which compounds comprises a &bgr;-lactam nucleus with a side chain coupled to it via an amide bond and which deacylation reaction is carried out in a mixture of water and an organic solvent and which deacylation leads to a &bgr;-lactam nucleus and a carboxylic acid, is carried out at a pH value of between 2 and 6 so that the carboxylic acid is extracted in situ to the organic solvent.

Type: Application

Filed: September 29, 2003

Publication date: March 18, 2004

Inventors: Thomas van der Does, Rienk Henrik Kuipers, Marjon Brigitte Diender, Jeroen Leonardus den Hollander, Adrianus Johannes Jozef Straathof, Lucas Antonius Maria van der Wielen, Joseph Johannes Heijnen
Methods for eradication of nanobacteria

Patent number: 6706290

Abstract: Nanobacteria contribute to pathological calcification in the human and animal body, including diseases such as kidney stones, salivary gland stones, dental pulp stones and atherosclerosis. The present invention provides methods for sterilizing articles contaminated with nanobacteria. The present invention also provides methods of treating patients infected with nanobacteria. In particular, the present invention provides a method for preventing the recurrence of kidney stones in a patient that has suffered from kidney stones, comprising administration of an antibiotic, a bisphosphonate, or a calcium chelator, either alone or in combination, in an amount effective to inhibit or prevent the growth and development of nanobacteria.

Type: Grant

Filed: July 2, 1999

Date of Patent: March 16, 2004

Inventors: Olvai E. Kajander, Neva Ciftcioglu
Cyclooxygenase-2 inhibitor and antibacterial agent combination for intramammary treatment of mastitis

Publication number: 20040033938

Abstract: A method is provided for treatment of an infective condition in an udder of a milk producing animal. The method comprises intramammary administration of an antibacterial agent in combination therapy with a selective COX-2 inhibitor in therapeutically effective amounts of each. Also provided is a pharmaceutical composition comprising an antibacterial agent and a selective COX-2 inhibitor, together with one or more excipients, in a dosage form suitable for intramammary administration to a milk producing animal.

Type: Application

Filed: March 20, 2003

Publication date: February 19, 2004

Inventors: Nancy J. Britten, Niki A. Waldron, Jeffrey L. Watts, John W. Hallberg
Use of 2,3 alkylcarbonyloxybenzoic acids in the treatment of anthrax

Publication number: 20040029783

Abstract: A method for treating inhalation anthrax is disclosed. The inventive method comprises the use of 2,3-alkylcarbonyloxybenzoic acid and salts thereof in the prevention and treatment of lung damage caused by Bacillus anthracis and toxins produced by the bacterium. The 2,3-alkylcarbonyloxybenzoic acid may be used alone or in combination with other therapeutic agents such as antibiotics.

Type: Application

Filed: October 31, 2002

Publication date: February 12, 2004

Inventor: Karen J. Stec
Treatment of neurological disease

Patent number: 6689756

Abstract: Provided is, among other things, a method of treating in an animal infection or neoplasm of cerebrospinal tissue characterized by a risk of death, the method comprising: (a) injecting a physiologically acceptable fluid for cerebrospinal perfusion into a first catheter into the cerebrospinal pathway, which fluid for cerebrospinal perfusion has an therapeutically effective amount an agent, the agent selected for effectiveness against the infection as identified or diagnosed; (b) withdrawing fluid at a second catheter into the cerebrospinal pathway to create a flow and flow pathway between the first and second catheters; and (c) maintaining the flow for a period of time adapted to perfuse at least 1 CSF volume.

Type: Grant

Filed: March 4, 2002

Date of Patent: February 10, 2004

Assignee: Integra LifeSciences Corporation

Inventors: David P. Hesson, Timothy J. Pelura, Glen D. Frazer
Cored tablets comprising amoxicillin and clavulanate

Publication number: 20040022855

Abstract: The present invention provides a cored tablet comprising a core layer containing clavulanate, and an outer layer containing amoxicillin and surrounding the core layer, and a method for preparing the same.

Type: Application

Filed: July 29, 2003

Publication date: February 5, 2004

Applicant: Daewoong Pharm Co., Ltd., Republic of Korea

Inventors: Dong-Jin Yoon, Min-Suk Lee, Young-Ghil Shin
Methods for preventing or treating disease mediated by toxin-secreting bacteria

Publication number: 20040023897

Abstract: Methods and pharmaceutical compositions for preventing and treating disease mediated by toxin-secreting bacteria. Inventive methods and compositions are suited to preventing or treating infections caused by bacterial toxins that enter host cells via receptor-mediated endocytosis (e.g., the anthrax and diphtheria toxins). Methods comprise a step of administering to an individual a pharmaceutical composition that includes an effective amount of an inhibitor of endosomal acidification. The inhibitor may be a primary amine, a carboxylic ionophore, or a selective inhibitor of the vacuolar proton pump (V-ATPase). The inhibitors of endosomal acidification may be employed in combination with other therapeutics such as antibiotics and antitoxins in order to prevent, treat or cure the disease.

Type: Application

Filed: November 12, 2002

Publication date: February 5, 2004

Inventor: Michael J. Caplan

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