1-thia-4-aza-bicyclo (3.2.0) Heptane Ring Containing (including Dehydrogenated) (e.g., Penicillins, Etc.) Patents (Class 514/192)
Spiro or additional polycyclo ring system (Class 514/193)
6,6-di-substituted (Class 514/194)
3-position substituent contains -cooc- group (Class 514/195)
6-position substituent contains hetero ring (Class 514/196)
6-position substituent contains carbocyclic ring (Class 514/197)
  • Methods for preventing or treating disease mediated by toxin-secreting bacteria
    Publication number: 20040023897
    Abstract: Methods and pharmaceutical compositions for preventing and treating disease mediated by toxin-secreting bacteria. Inventive methods and compositions are suited to preventing or treating infections caused by bacterial toxins that enter host cells via receptor-mediated endocytosis (e.g., the anthrax and diphtheria toxins). Methods comprise a step of administering to an individual a pharmaceutical composition that includes an effective amount of an inhibitor of endosomal acidification. The inhibitor may be a primary amine, a carboxylic ionophore, or a selective inhibitor of the vacuolar proton pump (V-ATPase). The inhibitors of endosomal acidification may be employed in combination with other therapeutics such as antibiotics and antitoxins in order to prevent, treat or cure the disease.
    Type: Application
    Filed: November 12, 2002
    Publication date: February 5, 2004
    Inventor: Michael J. Caplan
  • Treatment of conitions and disease
    Publication number: 20040019011
    Abstract: A combination for administration to a mammal which combination employs a therapeutically effective amount of a medicinal and/or therapeutic agent to treat a disease or condition and an amount of hyaluronic acid and/or salts thereof and/or homologues, analogues, derivatives, complexes, esters, fragments and subunits of hyaluronic acid sufficient to facilitate the agent's penetration through the tissue (including scar tissue) at the site to be treated, through the cell membranes into the individual cells to be treated.
    Type: Application
    Filed: July 28, 2003
    Publication date: January 29, 2004
    Inventors: Rudolf Edgar Falk, Samuel S. Asculai
  • Use of 2,3 alkylcarbonyloxybenzoic acids, derivatives and analogues therefrom in the treatment of tissue and cellular dysfunction, damage and injury in mammals
    Publication number: 20040019022
    Abstract: A method for treating cellular and tissue damage is disclosed. The inventive method comprises the use of 2,3-alkylcarbonyloxybenzoic acid and salts thereof in the prevention and treatment of dysfunction, damage, and/or injuries to organs, tissues and/or cells in human or animal subjects caused by diseases, infections and conditions such as pneumonia, coronavirus, multiple transfusions, trauma, ischemic-reperfusion dysfunctions, stroke, drug overdose, and severe acute respiratory syndrome. The 2,3-alkylcarbonyloxybenzoic acid may be used alone or in combination with other therapeutic agents such as antibiotics. The acid may be administered in any practical delivery form, and in free acid or buffered form.
    Type: Application
    Filed: July 18, 2003
    Publication date: January 29, 2004
    Inventors: Karen Stec, Israel Rubinstein, David Eiznhamer, Ze-Qu Xu, Michael Flavin
  • Combined preparation for the treatment of neoplasic diseases or of infectious diseases
    Publication number: 20040018184
    Abstract: The present invention relates to combined preparation containing as active substance the following individual components, in the form of a kit-of-parts:
    Type: Application
    Filed: July 21, 2003
    Publication date: January 29, 2004
    Applicant: I.D.M. IMMUNO-DESIGNED MOLECULES
    Inventors: Jacques Bartholeyns, Yves Fouron, Jean-Loup Romet-Lemonne
  • Antibiotic composition with inhibitor
    Publication number: 20030235615
    Abstract: Antibiotic composition having four dosage forms with different release profiles providing for initial release of a beta lactam antibiotic followed by release of a beta-lactamase inhibitor, followed by release of the antibiotic followed by release of the inhibitor. In a preferred embodiment, release from the second, third and fourth dosage forms is initiated after the component released from the immediately previous form reaches Cmax.
    Type: Application
    Filed: April 21, 2003
    Publication date: December 25, 2003
    Inventor: Edward M. Rudnic
  • Diagnosis and management of infection caused by Chlamydia
    Patent number: 6664239
    Abstract: The present invention provides a unique approach for the diagnosis and management of infections by Chlamydia species, particularly C. pneumoniae. The invention is based, in part, upon the discovery that a combination of agents directed toward the various stages of the chlamydial life cycle is effective in substantially reducing infection. Products comprising combination of antichlamydial agents, novel compositions and pharmaceutical packs are also described.
    Type: Grant
    Filed: March 19, 2002
    Date of Patent: December 16, 2003
    Assignee: Vanderbilt University
    Inventors: William M. Mitchell, Charles W. Stratton
  • Surfactant prevention of vaginitis and lung complications from cancer chemotherapy
    Publication number: 20030225034
    Abstract: A means and method for treating pulmonary fibrosis and vaginitis in animals is described. The compositions include surfactant lipids in a pharmaceutically acceptable carrier. Surfactant lipids have been found to suppress the synergistic effect of bleomycin and SP-A in enhancing proinflammatory cytokine production. Surfactant lipids are also effective in the prevention and treatment of pulmonary fibrosis resulting from exposure to inflammatory agents affecting cytokine production. Furthermore, surfactant lipids are effective in treating attenuating the effect of proinflammatory cytokine production in vaginitis.
    Type: Application
    Filed: May 2, 2003
    Publication date: December 4, 2003
    Applicant: The Penn State Research Foundation
    Inventors: Joanna Floros, David S. Phelps, Colin MacNeill, Todd M. Umstead, Zhenwu Lin, Judith Weisz
  • NOVEL FORMULATION
    Publication number: 20030224049
    Abstract: Bacterial infections may be treated using a high dosage regimen of amoxycillin and potassium clavulanate.
    Type: Application
    Filed: June 13, 2003
    Publication date: December 4, 2003
    Applicant: Beecham Pharmaceuticals (Pte) Limited
    Inventors: Kevin H. Storm, Creighton P. Conley, John A. Roush
  • Methods and reagents for the treatment of multiple sclerosis
    Publication number: 20030223959
    Abstract: The invention features methods and reagents for the diagnosis, monitoring, and treatment of multiple sclerosis. The invention is based in part on the discovery that Chlamydia is present in patients with multiple sclerosis, and that anti-chlamydial agents improve or sustain neurological function in these patients.
    Type: Application
    Filed: April 17, 2003
    Publication date: December 4, 2003
    Inventors: Charles W. Stratton, William M. Mitchell, Subramaniam Sriram
  • Parenteral, intravenous, and oral administration of oxazolidinones for treating diabetic foot infections
    Publication number: 20030216330
    Abstract: A method of treating a diabetic foot infection in a mammal includes oral, parenteral, or intravenous administration of a pharmaceutical formulation containing an orally, parenterally, or intravenously-effective amount, respectively of an oxazolidinone.
    Type: Application
    Filed: March 21, 2003
    Publication date: November 20, 2003
    Applicant: PHARMACIA & UPJOHN
    Inventor: Carl Norden
  • Topical treatment of prevention of ocular infections
    Publication number: 20030206956
    Abstract: The topical application of an azalide antibiotic such as azithromycin to the eye is useful in treating or preventing ocular infections. In one embodiment, the azalide antibiotic is supplied to the eye in a depot for sustained release. A more convenient dosing regimen can also be provided by the use of an appropriate depot. Furthermore, a composition containing a combination of medicaments is also provided.
    Type: Application
    Filed: April 7, 2003
    Publication date: November 6, 2003
    Applicant: INSITE VISION INCORPORATED
    Inventors: Chandler R. Dawson, Lyle M. Bowman
  • Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains
    Publication number: 20030199432
    Abstract: Co-administration of a lysostaphin or other anti-staphylococcal agent which cleaves cross-links of peptidoglycans of staphylococci cell walls such as lysostaphin and an antibiotic effective against staphylococci due to antibiotic activity mediated by cell-wall activity is effective against staphylococcal infection, even staphylococci that may be resistant to one or other of lysostaphin or the cell-wall active antibiotic. Co-administration simultaneously suppresses the generation of antibiotic-resistant mutant strains. Effective cell-wall active antibiotics include &bgr;-lactams and glycopeptides.
    Type: Application
    Filed: April 16, 2003
    Publication date: October 23, 2003
    Inventors: Michael Climo, Ellen Murphy, Gordon Archer
  • Diagnosis and management of infection caused by chlamydia
    Publication number: 20030195184
    Abstract: The present invention provides a unique approach for the diagnosis and management of infections by Chlamydia species, particularly C. pneumoniae. The invention is based, in part, upon the discovery that a combination of agents directed toward the various stages of the chlamydial life cycle is effective in substantially reducing infection. Products comprising combination of antichlamydial agents, novel compositions and pharmaceutical packs are also described.
    Type: Application
    Filed: March 19, 2002
    Publication date: October 16, 2003
    Inventors: William M. Mitchell, Charles W. Stratton
  • Combination therapy for the treatment of bacterial infections
    Publication number: 20030191051
    Abstract: The present invention provides compositions and methods for treating or preventing bacterial infections. The compositions and methods include the use of antibiotics and cyclooxygenase inhibitors.
    Type: Application
    Filed: January 21, 2003
    Publication date: October 9, 2003
    Inventors: Philip Needleman, Barry Hafkin
  • Use of sustained release antibiotic compositions in ophthalmic surgical procedures
    Patent number: 6630135
    Abstract: An improved method of sterilizing the field of surgery prior to an ophthalmic surgical procedure is described. The invention eliminates the need for painful and potentially traumatic injections of antibiotics by utilizing sustained release compositions which allow the antibiotics contained therein to penetrate deeply into the eye, thereby ensuring a sterile field of surgery during intraocular surgical procedures. The compositions may also be utilized to prevent post-surgical infections.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: October 7, 2003
    Assignee: Alcon Laboratories, Inc.
    Inventors: Gerald D. Cagle, Tai-Lee Ke, Barry A. Schlech, Ole J. Lorenzetti
  • Process for drying amoxicillin
    Publication number: 20030186956
    Abstract: Process for drying amoxicillin (compositions), characterised in that a gas, which is inert towards amoxicillin (compositions) and having a relative humidity content which is greater than zero is used for drying.
    Type: Application
    Filed: May 6, 2003
    Publication date: October 2, 2003
    Inventors: Hans Bilke, Otto Daemon, Franz Xaver Schwarz
  • Intraocular delivery compositions and methods
    Publication number: 20030185892
    Abstract: The present invention relates to intraocular drug delivery for treating ocular diseases. Particularly, the invention relates to particles useful for the delivery of certain pharmacologically active agents to treat ocular diseases. The particles contain calcium phosphate core particles, particularly nanoparticles, as delivery agents and adjuvants. The invention also relates to methods of making such particles and to methods of treating ocular disease by delivery of a therapeutic drug to an ocular surface using the particles of this invention. The invention further relates to methods of regulating ocular pressure using certain formulations according to the present invention.
    Type: Application
    Filed: November 27, 2002
    Publication date: October 2, 2003
    Inventors: Steve J. D. Bell, Qing He, Teh-Ching Chu, David E. Potter
  • Treatment of behavioral disorders with &bgr;-lactam compounds
    Patent number: 6627625
    Abstract: Administration of &bgr;-lactam compounds including &bgr;-lactam antibiotics and &bgr;-lactamase inhibitors provides significant neurotropic effects in warm-blooded vertebrates evidenced inter alia by anxiolytic and anti-aggressive behavior modification and enhanced cognition. Therapeutic methods for using such compounds and their pharmaceutical formulations are described.
    Type: Grant
    Filed: August 16, 2000
    Date of Patent: September 30, 2003
    Assignee: Revaax Pharmaceuticals, LLC
    Inventor: Gary A. Koppel
  • Method of administering an injectable antibiotic to an animal
    Publication number: 20030181398
    Abstract: A method of administering an antibiotic to an animal in need thereof, including the step of injecting the antibiotic subcutaneously at the junction of a pinna with the cranium of the animal, is disclosed.
    Type: Application
    Filed: March 19, 2003
    Publication date: September 25, 2003
    Inventor: Scott A. Brown
  • Antibiotic pharmaceutical composition with lysergol as bio-enhancer and method of treatment
    Publication number: 20030181425
    Abstract: The present invention relates to pharmaceutical composition with lysergol as bioactive enhancer and bioavailability facilitator for broad-spectrum antibiotics. The present invention has direct implication in reducing the dosage of antibiotics while increasing the efficiency of absorption of nutritional elements.
    Type: Application
    Filed: March 25, 2002
    Publication date: September 25, 2003
    Inventors: Suman Preet Singh Khanuja, Jai Shankar Arya, Santosh Kumar Srivastava, Ajit Kumar Shasany, Tiruppadiripuliyur Ranganathan Santha Kumar, Mahendra Pandurang Darokar, Sushil Kumar
  • Diagnosis and management of infection caused by Chlamydia
    Publication number: 20030171348
    Abstract: The present invention provides a unique approach for the diagnosis and management of infections by Chlamydia species, particularly C. pneumoniae. The invention is based, in part, upon the discovery that a combination of agents directed toward the various stages of the chlamydial life cycle is effective in substantially reducing infection. Products comprising combination of antichlamydial agents, novel compositions and pharmaceutical packs are also described.
    Type: Application
    Filed: March 19, 2002
    Publication date: September 11, 2003
    Inventors: William M. Mitchell, Charles W. Stratton
  • Bioavailability enchancing activity of Zingiber officinale Linn and its extracts/fractions thereof
    Publication number: 20030170326
    Abstract: The present invention relates to a bio enhancing composition containing extract and/or bioactive fraction/isolate from the plant Zingiber officinale in combinations combination with drugs, nutrients, nutraceuticals, micronutrients and herbal drugs/products and optionally containing piperine as a extract/active fraction obtained from piper nigrum, piper longum or its oleoresin as a bioavailability enhancer and its process for producing the extract or fractions from the plant source.
    Type: Application
    Filed: December 12, 2002
    Publication date: September 11, 2003
    Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
    Inventors: Ghulam Nabi Qazi, Kasturi Lal Bedi, Rakesh Kamal Johri, Manoj Kumar Tikoo, Ashok Kumar Tikoo, Subhash Chander Sharma, Sheikh Tasaduq Abdullah, Om Parkash Suri, Bishan Datt Gupta, Krishan Avtar Suri, Naresh Kumar Satti, Ravi Kant Khajuria, Surjeet Singh, Anamika Khajuria, Bal Krishan Kapahi
  • Inorganic-polymer complexes for the controlled release of compounds including medicinals
    Publication number: 20030170307
    Abstract: This invention relates generally to the production and use of inorganic-polymer complexes for the controlled release of compounds including medicinals. Advantageously, the inorganic used is calcium sulfate.
    Type: Application
    Filed: February 13, 2003
    Publication date: September 11, 2003
    Applicant: Royer Biomedical, Inc.
    Inventor: Garfield P. Royer
  • Glucocorticoid blocking agents for increasing blood-brain barrier permeability
    Publication number: 20030162695
    Abstract: Glucocorticoid blockers, including glucocorticoid receptor antagonists, are effective to prevent glucocorticoid-induced decrease in permeability of the blood-brain barrier and to increase the permeability of the blood-brain barrier. Administration of glucocorticoid blockers, including glucocorticoid receptor antagonists, concomitant with administration of drugs for treating diseases of the central nervous system increases delivery of such drugs into the central nervous system.
    Type: Application
    Filed: February 27, 2002
    Publication date: August 28, 2003
    Inventors: Alan F. Schatzberg, Steven Lindley, Joseph K. Belanoff
  • Microdose therapy
    Patent number: 6610652
    Abstract: Methods for treating vascular conditions associated with localized imbalance in vascular tone, which are hypothesized to be largely due to elevated endothelin (ET) are provided. The methods involve administration of nitric oxide (NO), agents which are able to provide NO, such as NO donors, agents which activate guanyl cyclase, such as YC-1, or agents which prolong the actions of endogenous NO or cyclic guanosine monophosphate (cGMP; a 2nd messenger molecule), such as phosphodiesterase (PDE) inhibitors. According to the invention, such agents are administered in minimal doses or microdoses by any route known in the art, so as to provide dosages which are about one half to about one twentieth (½ to {fraction (1/20)}) of those known to induce vasodilation in “normal” circulations.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: August 26, 2003
    Assignee: Queen's University at Kingston
    Inventors: Michael A. Adams, Jeremy P. W. Heaton, James D. Banting
  • Neurotherapeutic composition and method therefor
    Publication number: 20030158172
    Abstract: Neurotherapeutically pharmaceutical effective compositions are prepared using carboxypeptidase E inhibitors. One class of carboxypeptidase E inhibitors found to exhibit significant neurotropic activity are &bgr;-lactam compounds, particularly penam and cephem &bgr;-lactam antibiotics and non-antibiotic derivatives thereof.
    Type: Application
    Filed: August 20, 2002
    Publication date: August 21, 2003
    Inventors: Gary A. Koppel, Michael O. Chaney
  • Ionic antimicrobial coating
    Publication number: 20030147960
    Abstract: This invention relates to an ionic antimicrobial coating. Such a coating may contain (1) a water-insoluble polymer having a first ionized group and (2) an antimicrobial agent having a second ionized group with a charge opposite to that of the first ionized group, in which the antimicrobial agent is attached to the water-insoluble polymer via an ionic bond between the first ionized group and the second ionized group.
    Type: Application
    Filed: February 21, 2003
    Publication date: August 7, 2003
    Inventors: Tung-Liang Lin, Min-Shyan Sheu
  • Helicobacter GHPO 1360 and GHPO 750 polypeptides and corresponding polynucleotide molecules
    Publication number: 20030143242
    Abstract: The invention provides Helicobacter polypeptides, designated GHPO 1360 and GHPO 750, which can be used in vaccination methods for preventing or treating Helicobacter infection, and polynucleotides that encode these polypeptides.
    Type: Application
    Filed: January 3, 2002
    Publication date: July 31, 2003
    Inventors: Harold Kleanthous, Ling Lissolo, Jean-Francois Tomb, Charles Miller, Amal Al-Garawi
  • Compositions and methods for treating diarrhea
    Publication number: 20030143293
    Abstract: This invention relates to compositions, methods, combinations, and kits for treating, preventing, or reducing the risk of developing diarrhea in a mammal; or treating, preventing, or reducing the risk of developing a symptom associated with, or related to, diarrhea in a mammal. In particular, the compositions, methods, combinations, and kits comprise an anti-diarrheal agent and an electrolyte.
    Type: Application
    Filed: January 31, 2002
    Publication date: July 31, 2003
    Inventor: Sergei Shushunov
  • Zero-order sustained release dosage forms and method of making same
    Publication number: 20030133982
    Abstract: The present invention relates to zero-order sustained release solid dosage forms suitable for administration of a wide range of therapeutically active medicaments, especially those that are water-soluble, and to a process of making same. The solid dosage form comprises (a) a matrix core comprising ethylcellulose and the active agent and (b) a hydrophobic polymer coating encasing the entire matrix core.
    Type: Application
    Filed: December 19, 2002
    Publication date: July 17, 2003
    Inventors: John M. Heimlich, Loksidh D. Ganorkar, Ernest J. Lee, Robert M. Noack, Ronald R. VerHage
  • Method and composition for treatment and/or prevention of antibiotic-resistant microorganism infections
    Publication number: 20030134779
    Abstract: The present invention relates to a new composition, use and method to improve the cure of infections caused by antibiotic resistant microbial pathogens, in particular beta-lactam resistant microorganisms. Lactoferrin (LF) or Lactoferricin (LFC) can be administrated alone or in combination with antibiotic to affect growth, physiology and morphology of targeted microorganism. Lactoferrin increase susceptibility and can reverse resistance of microorganism to antibiotics.
    Type: Application
    Filed: September 23, 2002
    Publication date: July 17, 2003
    Inventors: Moussa S. Diarra, Pierre Lacasse, Denis Petitclerc
  • Inhibitors of ABC drug transporters in multidrug resistant microbial cells
    Publication number: 20030130171
    Abstract: The present invention relates to microbial multidrug resistance and, in particular, to compounds that microbial drug transporters of the ABC protein superfamily. The invention also relates to methods for selecting or designing compounds for the ability to inhibit drug transporter proteins and to methods of inhibiting drug transporter proteins. The invention concerns the new use of opioid receptor antagonists in the treatment of multidrug resistant microbial infections.
    Type: Application
    Filed: October 30, 2001
    Publication date: July 10, 2003
    Inventor: Grant L. Schoenhard
  • Pharmaceutical formulations comprising amoxycillin and clavulanate
    Publication number: 20030124187
    Abstract: Novel coamoxiclav formulations are described, having reduced weight compared to existing formulations, as well as formulations comprising amoxycillin and potassium clavulanate in a ratio of 8:1 and formulations prepared from granulates of amoxycillin and granulates of amoxycillin and clavulanate.
    Type: Application
    Filed: November 22, 2002
    Publication date: July 3, 2003
    Applicants: SmithKline Beecham Laboratoires Pharmaceutiques,, SmithKline Beecham s.a., SmithKline Beecham Corporation
    Inventors: Jacky Andre Gustave Mention, Jose Luis Sanroma Bordallo, Kevin Huntley Storm
  • Pharmaceutical formulations comprising sodium amoxycillin and potassium clavulanate
    Publication number: 20030118640
    Abstract: A tablet formulation comprising amoxycillin and potassium clavulanate, in a weight ratio amoxycillin:clavulanate between 1:1 to 20:1 (expressed as the weight of the corresponding parent acids) inclusive, wherein the amoxycillin is sodium amoxycillin or a mixture of sodium amoxycillin and amoxycillin trihydrate and the tablet has an enteric film coating is of use in treating bacterial infection.
    Type: Application
    Filed: November 6, 2002
    Publication date: June 26, 2003
    Inventor: Malcolm Dash
  • Composition based on etyl ester of linoleic acid and triethyl ester of citric acid for topical use in the treatment of seborrhea and acne
    Publication number: 20030118623
    Abstract: The present invention relates to a composition for topical use for treating and improving the aesthetic conditions of the skin, which comprises, as an active ingredient, a mixture of ethyllinoleate and triethylcitrate. This composition is active in the treatment of seborrhea and acne.
    Type: Application
    Filed: December 16, 2002
    Publication date: June 26, 2003
    Inventor: Gianfranco de Paoli Ambrosi
  • Taste masked aqueous liquid pharmaceutical composition
    Publication number: 20030118654
    Abstract: A substantially taste masked liquid pharmaceutical composition containing a pharmaceutically effective amount of an unpleasant tasting drug dissolved or dispersed in an aqueous excipient base, said excipient base comprising polyvinyl pyrrolidone and/or copolyvidone, and high molecular weight polyethylene glycol.
    Type: Application
    Filed: December 7, 2001
    Publication date: June 26, 2003
    Inventors: Joyce Bedelia B. Santos, Rita Josefina M. Santos, Kennie U. Dee
  • Use of combinations of active agents consisting of antimicrobially active substances and plant extracts containing terpene in veterinary medicine
    Publication number: 20030113385
    Abstract: Certain extracts of plants from the genera Leptospernum and Melaleuca can be used in the treatment of both mastitis and metritis to effectively reduce the amount of antibiotic employed, which extracts contain terpene.
    Type: Application
    Filed: August 15, 2002
    Publication date: June 19, 2003
    Applicant: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Werner Schleicher, Ernst Salamon
  • Diagnosis and management of infection caused by chlamydia
    Patent number: 6579854
    Abstract: The present invention provides a unique approach for the diagnosis and management of infections by Chlamydia species, particularly C. pneumoniae. The invention is based, in part, upon the discovery that a combination of agents directed toward the various stages of the chlamydial life cycle is effective in substantially reducing infection. Products comprising combination of antichlamydial agents, novel compositions and pharmaceutical packs are also described.
    Type: Grant
    Filed: May 6, 1998
    Date of Patent: June 17, 2003
    Assignee: Vanderbilt University
    Inventors: William M. Mitchell, Charles W. Stratton
  • Lipophilic drug compositions
    Publication number: 20030108596
    Abstract: The invention is directed to biologically active lipophilic compositions comprising a biologically active covalently attached to, or encapsulated within, a lipid. Preferably, a biologically active agent is both covalently attached to a lipid and encapsulated within a lipid composition. Preferred lipid components include triglycerides and fatty acids. The resulting composition is preferably adapted for oral administration.
    Type: Application
    Filed: April 29, 2002
    Publication date: June 12, 2003
    Inventor: Michael T. Sung
  • Pharmaceutical formulations comprising clavulanic acid alone or in combination with other beta-lactam antibiotics
    Publication number: 20030109503
    Abstract: A method of use of clavulanate to enhance the antibacterial activity of an antibacterial compound against microorganisms having an antibiotic resistance mechanism other than &bgr;-lactans enzyme mediated resistance. Pharmaceutical formulations and methods of use which exploit this method.
    Type: Application
    Filed: December 17, 2002
    Publication date: June 12, 2003
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Gillian Marjory Smith, Christine Elaine Thorburn, Karen Hazel Abbott, Tim Neil Brown
  • Targeted vesicular constructs for cytoprotection and treatment of H. pylori infections
    Patent number: 6576625
    Abstract: A composition for targeted vesicular for treatment of H-Pylori infections and for protection of the cell. The composition contains lectins, phospholipids, sterols, and one or more drugs. The composition is useful for treating H-Pylori infections and other diseases associated therewith and also helps in protecting cell walls.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: June 10, 2003
    Assignee: Panacea Biotic Limited
    Inventors: Amarjit Singh, Rajesh Jain
  • Easy-to-take granules
    Publication number: 20030104066
    Abstract: There are provided granules having a good taking property wherein an active ingredient, at least one kind of soluble additive having an average particle size of smaller than 50 &mgr;m and at least one kind of disintegrator are contained.
    Type: Application
    Filed: October 29, 2002
    Publication date: June 5, 2003
    Inventors: Kouji Murai, Shoichi Narita, Takehiro Ogasa
  • Nitrate salts of antimicrobial agents
    Publication number: 20030105066
    Abstract: Nitrate salts of antimicrobial agents for the preparation of antimicrobial medicaments, specifically antiviral, antifungal and antibacterial medicaments.
    Type: Application
    Filed: July 24, 2002
    Publication date: June 5, 2003
    Inventors: Piero Del Soldato, Francesca Benedini
  • Antibiotic spray
    Publication number: 20030099599
    Abstract: The invention provides a propellant free, non-pressurized spray dispenser containing a suspension of an antibiotic effective for the treatment of group A streptococci for topical application to the throat.
    Type: Application
    Filed: November 21, 2002
    Publication date: May 29, 2003
    Inventor: Ora Shuval-Sudai
  • Amoxicillin-dicloxacillin antibiotic composition
    Publication number: 20030096007
    Abstract: An antibiotic product for delivering at least Amoxicillin or dicloxacillin that is comprised of three dosage forms with different release profiles with each of Amoxicillin and dicloxacillin being present in at least one of the dosage forms.
    Type: Application
    Filed: March 7, 2002
    Publication date: May 22, 2003
    Inventors: Edward M. Rudnic, James D. Isbister, Donald J. Treacy, Sandra E. Wassink
  • Antibiotic composition with inhibitor
    Patent number: 6565882
    Abstract: Antibiotic composition having four dosage forms with different release profiles providing for initial release of a beta lactam antibiotic followed by release of a beta-lactamase inhibitor, followed by release of the antibiotic followed by release of the inhibitor. In a preferred embodiment, release from the second, third and fourth dosage forms is initiated after the component released from the immediately previous form reaches Cmax.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: May 20, 2003
    Inventor: Edward M. Rudnic
  • Compositions comprising endotoxin neutralizing protein and derivatives and uses thereof
    Publication number: 20030087823
    Abstract: The present invention relates to the use of endotoxin neutralizing protein (ENP) and derivatives thereof as stand alone microbial inhibitors or as synergistic enhancers of antibiotics and preservatives. Compositions comprising ENP or alone or in combination with an antibiotic may be used to prevent or treat gram-negative bacterial infections, endotoxemia, septic shock, gram-positive bacterial infections, yeast infections and fungal infections.
    Type: Application
    Filed: September 11, 2002
    Publication date: May 8, 2003
    Applicant: Associates of Cape Cod, Inc.
    Inventors: Erik J. Paus, Norman R. Wainwright
  • Amoxicillin - clarithromycin antibiotic composition
    Publication number: 20030077323
    Abstract: An antibiotic product for delivering at least Amoxicillin or Clarithromycin that is comprised of three dosage forms with different release profiles with each of Amoxicillin and Clarithromycin being present in at least one of the dosage forms.
    Type: Application
    Filed: March 7, 2002
    Publication date: April 24, 2003
    Inventors: Edward M. Rudnic, James D. Isbister, Donald J. Treacy, Sandra E. Wassink
  • Pro-micelle pharmaceutical compositions
    Publication number: 20030078194
    Abstract: The present invention provides pro-micelle compositions comprising a pharmaceutically active agent encapsulated with a membrane of esterified C12-C18 fatty acids. In the mammalian intestine, exposure to C12-C18 fatty acids results in conversion of the pro-micelle to a stable micelle that effectively delivers the pharmaceutically active agent to the systemic circulation. The present invention further provides methods of making and using such compositions.
    Type: Application
    Filed: October 11, 2001
    Publication date: April 24, 2003
    Inventors: Young W. Cho, Kwang-Ho Lee
  • Pharmaceutical compositions primarily for the treatment of genitourinary infections
    Publication number: 20030073646
    Abstract: Compositions having synergistic effective amounts of one or more antibacterial agents, a nitroimidazole, and an antifungal agent effective against a Candida species. The compositions are particularly useful in the treatment of genitourinary infections.
    Type: Application
    Filed: July 10, 2002
    Publication date: April 17, 2003
    Inventor: Marton Milankovits