Patent number: 8466188
Abstract: This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer.
Type:
Grant
Filed:
October 12, 2007
Date of Patent:
June 18, 2013
Assignee:
Xenon Pharmaceuticals Inc.
Inventors:
Mikhail Chafeev, Sultan Chowdhury, Robert Fraser, Jianmin Fu, Rajender Kamboj, Duanjie Hou, Shifeng Liu, Mehran Seid Bagherzadeh, Serguei Sviridov, Shaoyi Sun, Jianyu Sun, Nagasree Chakka, Tom Hsieh, Vandna Raina
Patent number: 8399681
Abstract: The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalac
Type:
Grant
Filed:
August 3, 2012
Date of Patent:
March 19, 2013
Assignee:
Janssen Pharmaceutica NV
Inventors:
Gilles Bignan, Micheal Gaul, Guozhang Xu, Bao-Ping Zhao