Oxygen Of The Saccharide Radical Bonded Directly To A Polycyclo Ring System Of Three Or More Carbocyclic Rings Patents (Class 514/33)
  • Publication number: 20030060428
    Abstract: A substance including the chemical structures of bicyclo [3.2.1]octan or the chemical structures of kaurene for the use in a dietary supplementation or as a constituent in a medicament for the treatment of non-insulin dependent diabetes mellitus, hypertension and/or the metabolic syndrome. The unique chemical structures of bicyclo [3.2.1]octan alone or in a kaurene structure provides the substances, such as e.g. steviol, isosteviol and stevioside with the capability of enhancing or potentiating the secretion of insulin in a plasma glucose dependent manner. The substances including these unique chemical structures also have the capability of reducing the glucagon concentration in the blood and/or lowering the blood pressure thereby providing a self-regulatory treatment system for non-insulin dependent diabetes mellitus and/or hypertension.
    Type: Application
    Filed: July 31, 2002
    Publication date: March 27, 2003
    Inventors: Kjeld Hermansen, Soren Gregersen, Per Jeppesen
  • Patent number: 6538027
    Abstract: This invention provides compositions for repelling insects, particularly biting insects, such as mosquitoes, ticks, and biting flies comprising ratite oil, active fractions of ratite oil obtained by flash chromatography or compositions comprising mixtures of fatty acids found in ratite oil. Also provided are compositions for repelling insects comprising ratite oil, active fractions of ratite oil or compositions comprising mixtures of fatty acids found in ratite oil further comprising at least one additional insect repellent. Methods of repelling insects, particularly biting insects, are provided comprising topically applying ratite oil, active fractions of ratite oil, or compositions comprising mixtures of fatty acids found in ratite oil; or ratite oil, active fractions thereof, or compositions comprising fatty acids found in ratite oil and further comprising at least one additional insect repellent.
    Type: Grant
    Filed: February 15, 2001
    Date of Patent: March 25, 2003
    Assignee: AgraQuest, Inc.
    Inventors: Denise C. Manker, Pamela Gail Marrone, Stephen Judd
  • Publication number: 20030050255
    Abstract: This invention is directed to ophthalmic compositions comprising an ascomycin for once-a-day administration.
    Type: Application
    Filed: August 23, 2002
    Publication date: March 13, 2003
    Inventors: Michelle Pik-han Wong, Kasey Jon Minick, Shau-fong Yen
  • Patent number: 6528058
    Abstract: Art adjuvant composition for stimulating an effective immune resposne to an antigenic substance when co-administered to an animal with said antigenic substance, comprising: (a) a saponin with immune stimulating activity; (b) a polycationic polyelectrolyte with immune stimulating activity; and (c) an immunoadjuvant oil.
    Type: Grant
    Filed: November 30, 2000
    Date of Patent: March 4, 2003
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: John Alexander Edgar, Khin Aye Tahan
  • Patent number: 6521635
    Abstract: This invention provides methods that are useful for inhibiting a MXR transporter in a cell overexpressing a MXR gene but not overexpressing a Pgp gene by contacting the cell with an acridine derivative. The invention also provides for a method of treating a mammal suffering from a cancer, which overexpressing a MXR gene but not overexpress a Pgp gene, by the co-administration of a chemotherapeutic and an acridine derivative.
    Type: Grant
    Filed: January 22, 2001
    Date of Patent: February 18, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Susan Bates, Robert Robey
  • Publication number: 20030022856
    Abstract: Described herein are methods for ablation, i.e., elimination or reduction, of unwanted tissue, particularly tissue which is normal to be present in the body but is unwanted for either health or cosmetic reasons. In particular embodiments, there are described methods for elimination of fat tissue from the body. According to the methods described herein, a drug which acts to eliminate the undesired tissue is provided in a carrier which is biocompatible, capable of being administered by injection, and which effects a controlled release of the drug over time. The drug with carrier is administered by injection locally in the area of the unwanted tissue, resulting in elimination of the tissue in that local area.
    Type: Application
    Filed: January 30, 2002
    Publication date: January 30, 2003
    Applicant: The Regents Of The University of Michigan
    Inventors: Thomas Richardson, David J. Mooney
  • Publication number: 20030003095
    Abstract: Activated carbon, as well as compositions and kits comprising the same, are effective for preventing pregnancy and sexually transmitted diseases including HIV.
    Type: Application
    Filed: August 8, 2002
    Publication date: January 2, 2003
    Applicant: The Procter & Gamble Company
    Inventors: Richard Joseph Sunberg, Sheri Anne Hunt
  • Publication number: 20030003168
    Abstract: A composition is prepared by extracting phytochemicals from plant matter. This composition is enriched preferably in isoflavones, lignans, saponins, catechins and phenolic acids. Soy is the preferred source of these chemicals: however, other plants may also be used, such as red clover, kudzu, flax, and cocoa. The composition is a dietary supplement for treatment of various cancers, pre- and post-menstrual syndromes, and various other disorders.
    Type: Application
    Filed: May 1, 2002
    Publication date: January 2, 2003
    Inventors: Mark Empie, Eric Gugger
  • Publication number: 20020193317
    Abstract: The invention discloses the use of a number of saponins and sapogenins, notably those of steroidal structure, in the treatment of cognitive disfunction and similar conditions. Methods of treatment, and pharmaceutical compositions are also disclosed.
    Type: Application
    Filed: February 15, 2002
    Publication date: December 19, 2002
    Inventors: Zongqin Xia, Yaer Hu, Ian Rubin, Jonathan Brostoff, Brian Whittle, Weijun Wang, Phil Gunning
  • Publication number: 20020193322
    Abstract: A physiologically acceptable aqueous solution, and water-soluble compositions suitable for obtaining it, comprising a first physiologically acceptable compound of an acidic nature and a second physiologically acceptable compound of a basic nature that are able to give rise to a precipitate in water, characterized in that it also contains a trisubstituted salt of glycyrrhizic acid in a sufficient quantity to form a clear solution in water.
    Type: Application
    Filed: January 29, 2002
    Publication date: December 19, 2002
    Inventors: Leandro Baiocchi, Mauro De Gregorio
  • Publication number: 20020193323
    Abstract: Compositions and methods for promoting a healthy cardiovascular system and enhancing healthy blood flow by gently removing toxic buildup from the arterial walls and dilating and strengthening the arterial walls, in a mammal. The compositions comprise calcium; magnesium; selenium; manganese; zinc; potassium; vitamin E; vitamin A; alpha-lipoic acid; Allium sativum extract; Afecicago satiia extract; Chondrus crispus extract; L-cysteine; L-glutamic acid; glycine; and glutathione.
    Type: Application
    Filed: March 15, 2002
    Publication date: December 19, 2002
    Inventor: Inna Yegorova
  • Publication number: 20020187211
    Abstract: A composition is prepared by extracting phytochemicals from plant matter. This composition is enriched preferably in isoflavones, lignans. saponins. catechins and phenolic acids. Soy is the preferred source of these chemicals: however other plants may also be used, such as red clover, kudzu, flax, and cocoa. The composition is a dietary supplement for treatment of various cancers, pre- and post-menstrual syndromes, and various other disorders.
    Type: Application
    Filed: May 1, 2002
    Publication date: December 12, 2002
    Inventors: Mark Empie, Eric Gugger
  • Patent number: 6476203
    Abstract: The present invention relates to a new and safe pharmaceutical composition for treating and preventing infertilities and increasing immune function. Specifically, this invention provides a new and safe composition, which is Icariin (ICN) extracted from Epimedium sagittatum Maxim, E. brevicornum Maxim and E. macranthum Morr. The chemical structure of Icariin is indicated. ICN also inhibits peroxidation significantly.
    Type: Grant
    Filed: March 14, 2002
    Date of Patent: November 5, 2002
    Inventor: Xinxian Zhao
  • Publication number: 20020156015
    Abstract: The present invention describes the use of fumitremorgin A, B and C and a series of diketopiperazines of Formula (I) to resensitize multidrug resistant (MDR) cancer cells to the cytotoxic effects of chemotherapeutic drugs.
    Type: Application
    Filed: February 28, 2002
    Publication date: October 24, 2002
    Applicant: American Cyanamid Company
    Inventors: Sridhar Krishna Rabindran, Haiyin He, Maya Prakash Singh, Lee Martin Greenberger
  • Publication number: 20020147201
    Abstract: The products and methods of the present invention provide a means for increasing the solubility and bioavailability of active agents. More particularly the invention provides compositions containing active agents as water-soluble complexes with glycyrrhizin, and methods of preparing such complexes. The invention further provides methods for the preparation of highly water soluble complex dosage forms.
    Type: Application
    Filed: February 8, 2002
    Publication date: October 10, 2002
    Applicant: Lavipharm Laboratories Inc.
    Inventors: Li-Lan H. Chen, Li Tao, Alfred Liang
  • Publication number: 20020137692
    Abstract: Novel compositions comprising a potassium channel opener, such as minoxidil, and a protein kinase C inhibitor, such as procyanidin B2 are presented, as are kits containing a first composition comprising a potassium channel opener and a second composition comprising a protein kinase C inhibitor. Also presented are methods for using the novel compositions for treating and preventing hair loss in a region of a patient.
    Type: Application
    Filed: January 29, 2002
    Publication date: September 26, 2002
    Applicant: Pharmacia AB
    Inventors: Jan Rundegren, Bo Kreilgaard
  • Publication number: 20020136751
    Abstract: An ingestible mollusc poison contains a simple metal compound, an activity enhancing additive such as ethylene diamine disuccinic acid (EDDS) and derivatives thereof, and a carrier material edible to molluscs. In one embodiment the active agent of the mollusc poison may be in the form of a metal complex of EDDS. The composition may be used alone or in conjunction with molluscicidal co-active agents and/or fertilizers.
    Type: Application
    Filed: November 7, 2001
    Publication date: September 26, 2002
    Inventor: George S. Puritch
  • Patent number: 6451837
    Abstract: A method is provided for therapeutic use of a class of compounds that are effective in protecting nerve cells from deterioration and cell death arising from degenerative disease, trauma or aging and may be used to achieve a similar effect in male and female subjects with minimal adverse side effects. The method comprises administering a therapeutically effective dose of a natural or synthetic bioflavonoid that acts as an MAPK cascade antagonist. Examples of bioflavonoids that may be used in the present method are apigenin and 2-(2′-amino-3′ methoxyphenyl)-oxanaphthalen-4-one (PD098059).
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: September 17, 2002
    Inventor: Andrius Baskys
  • Publication number: 20020115622
    Abstract: The present invention provides a therapeutic agent and therapeutic method for treatment of mastitis in livestock comprising glycyrrhizin and pharmaceutically acceptable salts thereof as effective ingredients.
    Type: Application
    Filed: November 26, 2001
    Publication date: August 22, 2002
    Inventors: Katsuo Kumagai, Kenzo Kai, Ken-ichi Komine
  • Publication number: 20020115623
    Abstract: The invention provides the use of the saponin derivatives, which is of the general formula (I) or the pharmaceutically acceptable salts and esters thereof: 1
    Type: Application
    Filed: December 17, 2001
    Publication date: August 22, 2002
    Applicant: Shui-Tein Chen
    Inventors: Chi-Yue Wu, Shui-Tein Chen, Ying-Chieh Tsai
  • Publication number: 20020110604
    Abstract: A novel formulation is provided that serves to synergistically inhibit the generation of free radicals and oxidative stress in animals. The formulation comprises as a first component a carotenoid species, and, as a second component, at least one member selected from the group consisting of lipoic acid, dihydrolipoic acid (DHLA), a stilbene species, ergothioneine, a flavone species, a triterpene species, ascorbic acid and derivatives thereof.
    Type: Application
    Filed: August 9, 2001
    Publication date: August 15, 2002
    Applicant: Ashni Naturaceuticals, Inc.
    Inventors: John G. Babish, Terrence Howell
  • Publication number: 20020107209
    Abstract: A method of treating polycystic kidney disease is described. The method involves administering soyasaponin Bb to an animal in need thereof.
    Type: Application
    Filed: September 28, 2001
    Publication date: August 8, 2002
    Inventors: Bruce J. Holub, F. William Collins, Dominique P. Bureau, Diana J. Philbrick
  • Publication number: 20020098175
    Abstract: Food composition in the form of a flour comprising at least 50% of protein, less than 15% of carbohydrates and 35 to 50% of plant fibers; preferably the carbohydrate content is less than 10%, advantageously less than 5%; this composition may be used as a substitute for wheat flour in the preparation of foods such as pasta, bread, bread sticks, bakery products and pastries and constitutes the basis of a method for improving the appearance of a person by achieving a loss of weight which is beneficial from the aesthetic point of view.
    Type: Application
    Filed: October 18, 2001
    Publication date: July 25, 2002
    Inventor: Mathias C. Zohoungbogbo
  • Publication number: 20020091093
    Abstract: Methods for treating, preventing, or inhibiting diseases and disorders associated with inflammation, cell-proliferation, and pain comprising the administration of a compound having the structural formula 1
    Type: Application
    Filed: November 27, 2001
    Publication date: July 11, 2002
    Inventors: Robert S. Jacobs, Russell G. Kerr
  • Publication number: 20020086815
    Abstract: The present invention provides illudin analogs of the general formula I: 1
    Type: Application
    Filed: November 5, 2001
    Publication date: July 4, 2002
    Applicant: The Regents of the University of California
    Inventors: Trevor C. McMorris, Michael J. Kelner
  • Publication number: 20020076452
    Abstract: A novel formulation is provided that serves to inhibit the inflammatory response in animals. The formulation comprises, as a first component an effective amount of a sesquiterpene lactone species and an effective amount of a second component selected from the group consisting of a diterpene lactone species and a triterpene species or derivatives thereof, and provides synergistic anti-inflammatory effects in response to physical or chemical injury or abnormal immune stimulation due to a biological agent or unknown etiology.
    Type: Application
    Filed: July 31, 2001
    Publication date: June 20, 2002
    Applicant: Ashni Naturaceuticals, Inc.
    Inventors: John G. Babish, Terrence Howell, Linda Pacioretty
  • Patent number: 6399579
    Abstract: Compositions for maintaining normal sexual function and treating sexual dysfunction in males and females comprising at least 15% by weight icariside I or at least 3.5% by weight anhydroicaritin, derived from extracts of plants belonging the Epimedium genus, and methods for preparing the same, are provided. The methods comprise subjecting an Epimedium extract to mild acid hydrolysis. Methods for maintaining normal sexual function and treating sexual dysfunction in both males and females are also provided, comprising oral administration of an effective amount of a novel composition of this invention comprising at least 15% by weight icariside I or at least 3.5% by weight anhydroicaritin.
    Type: Grant
    Filed: August 15, 2000
    Date of Patent: June 4, 2002
    Assignee: Hauser, Inc.
    Inventors: Rod Lenoble, Steven L. Richheimer, David Bailey, Coralee G. Mannila, Rebecca L. Nichols
  • Patent number: 6395711
    Abstract: The compound referred to herein as IB-962 12, having structure (I) can be obtained by cultivating the strain of Micromonospora sp. ES25-008, available under the accession number CECT-3333, and can be hydrolyzed to give IB-96212B having structure (II). The sugar substituent which is L-rhodinose, can its elf be derivatized or the sugar can be replaced, in either case, giving further derivatives of IB-96212 having a group other than L-rhodinose at the position of the sugar.
    Type: Grant
    Filed: April 17, 2000
    Date of Patent: May 28, 2002
    Assignee: Instituto Biomar S.A.
    Inventors: Rosa Isabel Fernandez-Chimeno, Francisco Romero, Jose Luis Fernandez-Puentes, Julia Perez-Baz, Librada Maria Canedo, Fernando Espliego
  • Publication number: 20020054922
    Abstract: The cosmetic topical formulation of this invention is directed toward diminishing skin wrinkling, fine line, improving skin tone, and combinations thereof. Preferably, the topical formulation contains a matrix metalloproteinase inhibitor, MMPI, and advantageously includes a natural estrogen, e.g., a true estrogen compound, such as 17-beta estradiol, or an estrogen-like steroid, (such as various phytoestrogens found in herbal preparations), as opposed to a synthetic estrogen. Other forms of the cosmetic topical formulation of this invention include combinations of synthetic estrogen and MMP inhibitor. Exemplary synthetic estrogens include, but are not limited to, ethinyl estradiol and clomiphine citrate. The cosmetic topical formulation is safe and effective diminishing wrinkling, and improving skin tone.
    Type: Application
    Filed: June 29, 2001
    Publication date: May 9, 2002
    Inventors: David S. Lerner, Gregory Schultz
  • Publication number: 20020054928
    Abstract: Compositions which comprise, in a physiologically acceptable medium, at least one sapogenin or a derivative or natural extract containing the same, and at least one xanthine base are useful, in particular, for preventing or combating cellulite and/or for refining the figure or the contours of the face. Preferably, the composition comprises diosgenin or an extract of wild yam, combined with caffeine.
    Type: Application
    Filed: August 22, 2001
    Publication date: May 9, 2002
    Applicant: L'OREAL
    Inventor: Elisabeth Picard-Lesboueyries
  • Publication number: 20020013229
    Abstract: Improved methods and compositions for protecting plants or seeds from plant diseases are provided. Broadly, the compositions comprise (and preferably consist essentially of) saponin, such as triterpene type saponins extracted from Quinoa or Quillaja. The methods comprise contacting the portion of the plant (e.g., foliage, shoot, etc.) to be treated with a disease-inhibiting or protective amount of the composition. The compositions can also be used to treat plant seeds or tubers prior to planting thereof, as well as soil adjacent a growing plant. The inventive compositions are particularly useful for the treatment, control and/or prevention of fungal diseases. The saponins of the invention can be applied as liquids or dry particulates, and are especially suited for the treatment of potato seed, tubers and plants.
    Type: Application
    Filed: February 13, 2001
    Publication date: January 31, 2002
    Inventors: Joseph M. Dutcheshen, Theodore Anthony Danyluk
  • Patent number: 6329339
    Abstract: This invention relates to pharmaceutical compositions of and methods of treating viral infections with a synergistic combination of glycyrrhizic acid and either a lactoferrin or a lysozyme.
    Type: Grant
    Filed: January 18, 2000
    Date of Patent: December 11, 2001
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Raffaello Pompei, Mario Pinza
  • Patent number: 6326360
    Abstract: An object of the present invention is to obtain an oral glycyrrhizin preparation not only manufacturable by a simple method but also having an excellent property of being absorbed from the digestive tract. In the present invention, such oral preparations are made into enteric forms wherein glycyrrhizin is admixed with an effervescent agent in combination with an absorption enhancer such as a medium-chain fatty acid or a salt thereof. In the preparation of the present invention, it is now possible to achieve an excellent absorption of glycyrrhizin from the digestive tract by addition of an effervescent agent and, moreover, the preparation can be manufactured by a simple, convenient method without special steps.
    Type: Grant
    Filed: September 25, 2000
    Date of Patent: December 4, 2001
    Assignee: Grelan Pharmaceuticals Co., Ltd.
    Inventors: Hashime Kanazawa, Kenji Shimizu, Kazuhiro Sasaki, Tetsuya Sugimoto
  • Publication number: 20010034330
    Abstract: Compositions comprising oligonucleotides comprising at least one unmethylated CpG dinucleotide and saponin and the use thereof for stimulating innate immunity and enhancing natural killer cell activity are disclosed.
    Type: Application
    Filed: January 12, 2001
    Publication date: October 25, 2001
    Inventor: Charlotte Kensil
  • Patent number: 6214863
    Abstract: Disclosed are combinations of a taxoid, an alkylating agent and an anthracycline antibiotic, which compositions exhibit therapeutic synergy in the treatment of cancer.
    Type: Grant
    Filed: August 10, 1999
    Date of Patent: April 10, 2001
    Assignee: Aventis Pharma S.A.
    Inventor: Marie-Christine Bissery
  • Patent number: 6149913
    Abstract: Compositions and methods for controlling the population of insects are disclosed. The compositions include a feeding stimulant for a particular insect, an effective amount of a 1-arylpyrazole or nicotinyl insecticide to kill an desired insect, at a concentration which is not typically toxic when applied to a plant in the absence of a feeding stimulant and the insect consumes an ordinary amount of toxin during the course of normal feeding, but is toxic when applied in conjunction with a feeding stimulant which causes the insect to consume more of the toxin than would normally be consumed during normal feeding. The use of normally non-toxic amounts of insecticides allows one to minimize the residual insecticide present on the crops.
    Type: Grant
    Filed: November 16, 1998
    Date of Patent: November 21, 2000
    Assignee: Rhone-Poulenc AG Company, Inc.
    Inventor: Keith Holmes
  • Patent number: 6107284
    Abstract: Water-soluble derivatives of epipodophyllotoxin, process for their preparation and their use for the treatment of rheumatoid arthritis, complaints caused by human papilloma virus and cancer.
    Type: Grant
    Filed: April 21, 1997
    Date of Patent: August 22, 2000
    Assignee: Pierre Fabre Medicament
    Inventors: Thierry Imbert, Yves Guminski, Barbara Monse, Bridget Hill, Jean-Pierre Robin
  • Patent number: 6103765
    Abstract: Administration of a pharmaceutical composition comprising:(a) a vasodilator; and(b) a 15-hydroxyprostaglandindehydrogenase inhibitor is effective for the treatment of male erectile dysfunction.
    Type: Grant
    Filed: July 9, 1997
    Date of Patent: August 15, 2000
    Assignee: Androsolutions, Inc.
    Inventor: Gary W. Neal
  • Patent number: 6103768
    Abstract: The invention described here concerns the unique utility of fatty acids and their derivatives to eradicate existing fungal and bacterial infections in plants. Also, described herein are combination treatments whereby fatty acids are used to enhance or augment the activity of fungicides, bactericides, and biological control agents.
    Type: Grant
    Filed: September 8, 1997
    Date of Patent: August 15, 2000
    Assignee: Mycogen Corporation
    Inventors: Steven D. Savage, Steven L. Evans, Robert A. Haygood, Paul S. Zorner, Keith Jones
  • Patent number: 6022862
    Abstract: Methods of promoting would healing and the growth and proliferation of keratinocytes, fibroblasts and endothelial cells are disclosed. These methods comprise contacting a wound with an effective wound healing amount of a composition comprising a pseudopterosin or pseudopterosin derivative.
    Type: Grant
    Filed: December 3, 1997
    Date of Patent: February 8, 2000
    Assignee: VimRx Pharmaceuticals, Inc.
    Inventors: Howard B. Haimes, Pablo A. Jimenez
  • Patent number: 6022545
    Abstract: This invention describes the effect of a means to prevent the sexual transmission of infectious pathogens of the vaginal and uterine wall in women, farm animals and pets. This discovery concerns a means to disrupt the sexual transmission of infectious pathogens which attack the cavity living of the vagina and uterus of women, farm animals and pets which consists of a foam that prevents the docking of pathogens to the cavity lining and which acts as a pathogen-killing substance.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: February 8, 2000
    Assignee: Nouveau Technologies, Inc.
    Inventors: H. B. Schmittmann, J. Dietrich
  • Patent number: 5972993
    Abstract: A method for treating skin conditions, such as rosacea and sensitive skin, that manifest as a tendency towards flushing and blushing is provided. Also provided herein, are compositions for the treatment of rosacea and sensitive skin that are comprised of at least one antioxidant selected from the following groups of antioxidants: (a) phenolic compounds that contain at least one hydroxyl group connected directly to a benzene ring and to another unsaturated chemical grouping, (b) sulfur-containing compounds that contain at least one sulfhydryl groups or sulfur-containing compounds that contain at least one disulfide group, or (c) polyene compounds that have conjugated systems of double bonds.
    Type: Grant
    Filed: March 20, 1998
    Date of Patent: October 26, 1999
    Assignee: Avon Products, Inc.
    Inventor: Dmitri Ptchelintsev
  • Patent number: 5936074
    Abstract: The present invention is directed to deacyl teicoplanin, and to a process for preparing deacyl teicoplanin by reacting teicoplanin with ECB deacylase. Deacyl teicoplanin can be alkylated to produce compounds useful for their antibacterial activity.
    Type: Grant
    Filed: April 1, 1998
    Date of Patent: August 10, 1999
    Assignee: Eli Lilly and Company
    Inventors: Barbara Shreve Briggs, Robin David Grey Cooper, Adam Joseph Kreuzman, Milton Joseph Zmijewski, Jr.
  • Patent number: 5929113
    Abstract: This invention provides a method for repelling biting insects such as mosquitoes, ticks, and biting flies by topically applying to the skin of a subject emu oil, fractions of emu oil obtained by flash chromatography or a composition comprising emu oil or active fractions thereof and at least one other insect repellent such as citronella, DEET or saponin. Also provided are compositions for repelling biting insects comprising diluted fractions of emu oil, and compositions comprising emu oil or active fractions thereof and at least one other insect repellent such as citronella, DEET or saponin.
    Type: Grant
    Filed: June 16, 1997
    Date of Patent: July 27, 1999
    Assignee: AgraQuest, Inc.
    Inventors: Denise C. Manker, Pamela Gail Marrone, Stephen Judd
  • Patent number: 5908835
    Abstract: Disclosed are antitumor compositions comprising taxol, taxotere or their derivatives in combination with an anthracycline antibiotic, the combination having a pharmacologic activity greater than the expected additive effect of its individual components.
    Type: Grant
    Filed: November 10, 1997
    Date of Patent: June 1, 1999
    Assignee: Rhone-Poulenc Rorer, S.A.
    Inventor: Marie-Christine Bissery
  • Patent number: 5891912
    Abstract: The present invention related to compounds represented by the following formula (I) and salts thereof, ##STR1## wherein R.sup.1 and R.sup.4 each represents a carboxyl or a carboxyl which is converted into an ester, an amide or hydroxamic acid; R.sup.2 represents a lower alkyl or a phenyl-lower alkyl; R.sup.3 represents a hydrogen atom, a lower alkyl, an amino-lower alkyl, a lower alkylamino-lower alkyl, a hydroxy-lower alkyl, a mercapto-lower alkyl, a carboxy-lower alkyl, a lower alkoxycarbonyl-lower alkyl, an imidazolyl-lower alkyl, an indolyl-lower alkyl, a (substituted) phenyl group, a (substituted) phenyl-lower alkyl group, a (substituted) naphthyl group, or a (substituted) naphtyl-lower group. The compounds of the present invention have inhibitory effects on endopeptidase 24.
    Type: Grant
    Filed: July 15, 1996
    Date of Patent: April 6, 1999
    Assignee: Santen Pharmaceutical Co., Ltd.
    Inventors: Yoichi Kawashima, Ken-ichi Fujimura, Hiroshi Suhara, Nobuaki Miyawaki, Yuko Fujita
  • Patent number: 5843910
    Abstract: The present invention relates to novel colchicine derivatives of formula (1), where Y is a --CH.sub.2 --CH--NH--R.sub.3 group or a --CH--CH.sub.2 OR.sub.3 group and the other variables are as defined in claim 1, having antiproliferative, antitumoral and anti-inflammatory activities. The novel compounds have a cytotoxicity on human tumoral cell lines comparable with colchicine, but, in comparison with the latter, they are less toxic and more selective, particularly on cells resistant to the usual medicaments. Some compounds have a marked activity on TNF and interleukine 2, and therefore are very potent anti-inflammatory agents. They can be included in pharmaceutical formulations useful for the parenteral, oral and topical administrations.
    Type: Grant
    Filed: March 21, 1997
    Date of Patent: December 1, 1998
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Bruno Gabetta
  • Patent number: 5739118
    Abstract: Methods of introducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an individual with a genetic vaccine facilitator and administering to the cells, a nucleic acid molecule that is free of retroviral particles. The nucleic acid molecule comprises a nucleotide sequence that encodes a protein that comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen or an antigen associated with a hyperproliferative or autoimmune disease, a protein otherwise missing from the individual due to a missing, non-functional or partially functioning gene, or a protein that produce a therapeutic effect on an individual. Methods of prophylactically and therapeutically immunizing an individual against HIV are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.
    Type: Grant
    Filed: April 1, 1994
    Date of Patent: April 14, 1998
    Assignees: Apollon, Inc., The Trustees of the University of Pennsylvania
    Inventors: Richard A. Carrano, Bin Wang, David B. Weiner
  • Patent number: 5736523
    Abstract: This invention relates to a naphthoquinone derivatives, to processes and to intermediates for preparing these derivatives, to pharmaceutical composition and to the use of these derivatives as antitumor agents in mammals.
    Type: Grant
    Filed: March 10, 1995
    Date of Patent: April 7, 1998
    Assignee: Biochem Pharma Inc.
    Inventors: Giorgio Attardo, Tibor Breining, Marc Courchesne, Serge Lamothe, Jean-Fran.cedilla.ois Lavallee, Dieu Nguyen, Rabindra Rej, Yves St-Denis, Wuyi Wang, Yao-Chang Xu, France Barbeau, Elaine Lebeau, Jean Louis Kraus
  • Patent number: 5728683
    Abstract: An external preparation for skin comprising at least one member selected from the group consisting of escinol and its salts represented by the following constitutional formula (1): ##STR1## (wherein R.sup.1 is hydrogen atom or hydroxyl group and R.sup.2 is pyranose residue.)Due to the effect of escinol which characterizes the present invention, the external preparation in accordance with the present invention is excellent in whitening effect and has a high safety.
    Type: Grant
    Filed: April 19, 1996
    Date of Patent: March 17, 1998
    Assignee: Shiseido Co., Ltd.
    Inventors: Kazuhisa Maeda, Rumiko Kaku, Yoshihiro Yokokawa, Minoru Fukuda