Oxygen Of The Saccharide Radical Bonded Directly To A Polycyclo Ring System Of Three Or More Carbocyclic Rings Patents (Class 514/33)
  • Publication number: 20040192623
    Abstract: The invention relates to aloe-emodin (AE) derivatives and their use as anticancer drugs. Saids derivatives show a specific cytotoxicity to tumour cells, also of neuroectodermal origin, to which they may in particular act as aloe-emodin prodrugs. Said pharamcological profile makes them particularly suitable for use in the treatment of neoplasias. Thereofore, pharmaceutical compositions containing said compound may be usefully used in the treatment of neoplasias. It has surprisingly been found that aloe-emodin derivatives in position 3′ (bearing either a positive or negaive charge) exhibit improved sollubility properties and, at the same time, in vitro show cytotoxicity to tumour cells, also of neuroectodermal origin.
    Type: Application
    Filed: May 17, 2004
    Publication date: September 30, 2004
    Inventors: Giorgio Palu, Modesto Carli, Teresa Pecere, Giuseppe Zagotto
  • Publication number: 20040185127
    Abstract: The cosmetic topical formulation of this invention is directed toward diminishing skin wrinkling, fine line, improving skin tone, and combinations thereof. Preferably, the topical formulation contains a matrix metalloproteinase inhibitor, MMPI, and advantageously includes a natural estrogen, e.g., a true estrogen compound, such as 17-beta estradiol, or an estrogen-like steroid, (such as various phytoestrogens found in herbal preparations), as opposed to a synthetic estrogen. Other forms of the cosmetic topical formulation of this invention include combinations of synthetic estrogen and MMP inhibitor. Exemplary synthetic estrogens include, but are not limited to, ethinyl estradiol and clomiphine citrate. The cosmetic topical formulation is safe and effective diminishing wrinkling, and improving skin tone.
    Type: Application
    Filed: March 1, 2004
    Publication date: September 23, 2004
    Inventor: David S. Lerner
  • Publication number: 20040175443
    Abstract: Food supplement compositions and their methods of use in increasing lean mass and/or muscle size and/or strength in individuals, particularly, athletes is described. The food supplements described comprise a substance which increases nitric oxide production in the body, and, a source of amino acids. Other food supplements described comprise a substance which can enhance and/or mimic insulin activity, and a source of amino acids. The food supplement compositions described are suitable for supplementing the diet of an athlete and particularly for enhancing an athlete's muscle size or strength.
    Type: Application
    Filed: March 11, 2004
    Publication date: September 9, 2004
    Inventors: Paul T. Gardiner, Derek E. Woodgate, Mark S. Gilbert, Robert W. Thoburn
  • Publication number: 20040175447
    Abstract: The present invention relates to a feed, a fertilizer, a melanogenesis-inhibitory agent for animals and plants and a blackening/browning-inhibitory composition for animals and plants, each comprising, as an effective component, at least one member selected from the group consisting of pentacyclic triterpenes, physiologically acceptable salts thereof and derivatives thereof, which have an excellent melanogenesis-inhibitory effect.
    Type: Application
    Filed: March 19, 2004
    Publication date: September 9, 2004
    Applicant: The Nisshin OilliO, Ltd.
    Inventors: Yoshihiro Murano, Gou Shinohara, Noriyasu Kuno
  • Publication number: 20040175442
    Abstract: Food supplement compositions and their methods of use in increasing lean mass and/or muscle size and/or strength in individuals, particularly, athletes is described. The food supplements described comprise a substance which increases nitric oxide production in the body, and, a source of amino acids. Other food supplements described comprise a substance which can enhance and/or mimic insulin activity, and a source of amino acids. The food supplement compositions described are suitable for supplementing the diet of an athlete and particularly for enhancing an athlete's muscle size or strength.
    Type: Application
    Filed: March 11, 2004
    Publication date: September 9, 2004
    Inventors: Paul T. Gardiner, Derek E. Woodgate, Mark S. Gilbert, Robert W. Thoburn
  • Patent number: 6784159
    Abstract: A method of treating polycystic kidney disease is described. The method involves administering soyasaponin Bb to an animal in need thereof.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: August 31, 2004
    Assignees: Her Majesty the Queen in right of Canada, as represented by the Minister of Agriculture, University of Guelph
    Inventors: Bruce J. Holub, F. William Collins, Dominique P. Bureau, Diana J. Philbrick
  • Publication number: 20040162248
    Abstract: The present invention relates to application of compounds of formula (1) (Gibberellins) and their derivatives for the preparation of a pharmaceutical composition or medicaments for the treatment of diabetes, its complications and associated conditions, including obesity, micro and macro vascular diseases, nephropathy, neuropathy, eye diseases, diabetic ulcerations and the like. The method results the normalization of serum glucose level and other physiological conditions.
    Type: Application
    Filed: February 12, 2004
    Publication date: August 19, 2004
    Inventors: Peter James Jenkins, Minnie Wu, David Shine Wu
  • Publication number: 20040152645
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo.
    Type: Application
    Filed: January 20, 2004
    Publication date: August 5, 2004
    Applicants: Board of Trustees of Michigan State University, The Regents of the University of California
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow
  • Publication number: 20040142882
    Abstract: The object of the present invention is to provide the use of glycyrrhizin and its derivatives for induction of RANTES. The present invention discloses an RANTES induction method and pharmaceutical composition for the same comprising administration of glycyrrhizin and its derivatives in an amount effective for treating or preventing decreases in infection resistance to opportunistic infections occurring in burn patients, AIDS patients, cancer patients, encephalitis patients, individuals having suffered serious injuries or undergone major surgery, or individuals subject to stress.
    Type: Application
    Filed: October 27, 2003
    Publication date: July 22, 2004
    Inventors: Fujio Suzuki, Makiko Kobayashi, Tokuichiro Utsunomiya, Hiroatsu Matsumoto, Midori Takeda, Shigemi Iwata
  • Publication number: 20040138151
    Abstract: Saponins of formula 1
    Type: Application
    Filed: January 6, 2004
    Publication date: July 15, 2004
    Applicants: Janssen Pharmaceutica N.V., National Center for Science and Technology, Universiteit Gent
    Inventors: Louis Jules Roger Marie Maes, Nils Albert Gilbert Germonprez, Luc Emiel Mathilde Van Puyvelde, Norbert G. M. De Kimpe, Tran Ngoc Ninh
  • Publication number: 20040116361
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo.
    Type: Application
    Filed: November 26, 2003
    Publication date: June 17, 2004
    Applicants: Board of Trustees of Michigan State University, The Regents of the University of California
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow
  • Publication number: 20040101579
    Abstract: A soya extract having a content of glucoside isoflavones of at least 13% by weight and a content of 0.6 to 1.5 parts by weight of group 3 soya saponins per 1 part by weight of glucoside isoflavones. Also, pharmaceutical compositions containing this extract and methods of administering the extract to treat conditions such as pre- or post-menopausal symptoms, cancer, such as breast or prostate cancer, or alcoholism. The extracts are made by a process which includes the steps of treating ripe whole soya beans or oil-free soya flour with an aliphatic alcohol to obtain a first extract; concentrating the first extract to form a concentrated first extract; purifying the concentrated first extract by treatment with at least one aliphatic hydrocarbon; and extracting active components from the purified concentrated first extract with a water-immiscible aliphatic alcohol to obtain a second extract. Preferably, the final extract is concentrated dried to form the desired soya extract.
    Type: Application
    Filed: June 30, 2003
    Publication date: May 27, 2004
    Applicant: Indena SpA
    Inventors: Ezio Bombardelli, Bruno Gabetta
  • Publication number: 20040097436
    Abstract: Methods of treating a bacterial infection and of killing or inhibiting bacteria are disclosed. The methods use derivatives of triterpenes that are abundant in birch bark and other plants. The triterpenes include betulin, allobetulin, and lupeol.
    Type: Application
    Filed: November 11, 2003
    Publication date: May 20, 2004
    Applicant: Regents of the University of Minnesota
    Inventors: Pavel A. Krasutsky, Robert M. Carlson, Raj Karim
  • Publication number: 20040086585
    Abstract: A method of inhibiting amyloid formation, deposition, accumulation, or persistence, or amyloid protein-amyloid protein interactions, amyloid-proteoglycan interactions, amyloid-PG/GAG interactions and/or amyloid-glycosaminoglycan interactions, and/or dissolving or disrupting pre-formed or pre-deposited amyloid fibrils in Alzheimer's Disease in a mammalian subject. In the method a therapeutically effective amount of plant matter from the genus Uncaria, species tomentosa is administered, preferably from the inner bark or root tissue of Uncaria tomentosa.
    Type: Application
    Filed: June 30, 2003
    Publication date: May 6, 2004
    Inventors: Gerardo Castillo, Alan D. Snow
  • Publication number: 20040082528
    Abstract: This invention relates to a use of hederagenin 3-O-&agr;-L-rhamnopyranosyl((1→2)-[&bgr;-D-glucopyranosyl(1→4)]-&agr;-L-arabinopyranoside or a Pulsatillae radix extract containing the same as a therapeutic agent for solid tumors.
    Type: Application
    Filed: July 15, 2003
    Publication date: April 29, 2004
    Inventors: Song-Bae Kim, Byung-Zun Ahn, Yong Kim
  • Publication number: 20040081672
    Abstract: The present invention relates to application of niacinamide, niacin, and niacin esters (nicotinic acid esters) derivatives of skin beneficial organic acids (henceforth called “derivatives”) for the synergistic treatment or prevention of topical disorders of skin such as acne, rosacea, skin wrinkles, age-spots, canker sores, striae distensae (stretch marks), pimples, and skin redness. These “derivatives” are made by a very simple in-situ method. These “derivatives” provide enhanced bioavailability of both ingredients that are combined to form such derivatives. The “derivatives” of present invention can be formulated in a wide variety of delivery systems including traditional water and oil emulsions, suspensions, colloids, solutions, or anhydrous systems.
    Type: Application
    Filed: October 25, 2002
    Publication date: April 29, 2004
    Inventor: Shyam K. Gupta
  • Publication number: 20040081709
    Abstract: The invention discloses the use of a smilagenin in the treatment of cognitive dysfunction and similar conditions. Methods of treatment, and pharmaceutical compositions are also disclosed.
    Type: Application
    Filed: October 21, 2003
    Publication date: April 29, 2004
    Inventors: Zongqin Xia, Ian Rubin, Brian Whittle, Philip Gunning, Yaer Hu, Jonathan Brostoff, Weijun Wang
  • Publication number: 20040067224
    Abstract: A formulation for enteral administration to a patient is disclosed.
    Type: Application
    Filed: August 22, 2003
    Publication date: April 8, 2004
    Inventor: Stephen P Ernest
  • Publication number: 20040067899
    Abstract: The present invention provides a therapeutic agent and therapeutic method for treatment of mastitis in livestock comprising glycyrrhizin and pharmaceutically acceptable salts thereof as effective ingredients.
    Type: Application
    Filed: July 28, 2003
    Publication date: April 8, 2004
    Inventors: Katsuo Kumagai, Kenzo Kai, Ken-Ichi Komine
  • Patent number: 6716421
    Abstract: This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such that the termiticide causes death to about 50 to about 100% of termites within about 24 to about 84 days after the termites begin to ingest the termiticide or the bait matrix comprising the termiticide, b) a cellulose containing material, and c) water. The termiticidal bait matrix can be used in a bait station installed in the ground. The kits are suitable to be used by consumers in their homes.
    Type: Grant
    Filed: March 5, 2001
    Date of Patent: April 6, 2004
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Philip Frederick Brode, III, Garry Steven Garrett, Leo Timothy Laughlin, Randall Stryker Matthews, Dale Edwin Barker, Daniel James Kinne, Gary Eugene McKibben, Christopher Miles Miller, Timothy Robert Probst
  • Patent number: 6713074
    Abstract: The cosmetic topical formulation of this invention is directed toward diminishing skin wrinkling, fine line, improving skin tone, and combinations thereof. Preferably, the topical formulation contains a matrix metalloproteinase inhibitor, MMPI, and advantageously includes a natural estrogen, e.g., a true estrogen compound, such as 17-beta estradiol, or an estrogen-like steroid, (such as various phytoestrogens found in herbal preparations), as opposed to a synthetic estrogen. Other forms of the cosmetic topical formulation of this invention include combinations of synthetic estrogen and MMP inhibitor. Exemplary synthetic estrogens include, but are not limited to, ethinyl estradiol and clomiphine citrate. The cosmetic topical formulation is safe and effective diminishing wrinkling, and improving skin tone.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: March 30, 2004
    Assignees: Quick Med Technologies Inc., University of Florida Research Foundation, Inc.
    Inventors: David S. Lerner, Gregory Schultz
  • Patent number: 6699841
    Abstract: A physiologically acceptable aqueous solution, and water-soluble compositions suitable for obtaining it, comprising a first physiologically acceptable compound of an acidic nature and a second physiologically acceptable compound of a basic nature that are able to give rise to a precipitate in water, characterized in that it also contains a trisubstituted salt of glycyrrhizic acid in a sufficient quantity to form a clear solution in water. A method for preparing the said solution.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: March 2, 2004
    Inventors: Leandro Baiocchi, Mauro De Gregorio
  • Patent number: 6693085
    Abstract: Compound JK represented by the general formula (1): wherein R is H or —CH3; or a pharmaceutically acceptable salt thereof. Compound JK has an excellent antimicrobial activity even against resistant strains including MRSA and is useful as an anti-microbial agent.
    Type: Grant
    Filed: October 26, 2001
    Date of Patent: February 17, 2004
    Assignee: Higeta Shoyu Co., Ltd.
    Inventors: Yasushi Tanaka, Hisayuki Komaki, Akira Nemoto, Katsukiyo Yazawa, Yuzuru Mikami
  • Publication number: 20040014692
    Abstract: Methods for promoting healthy body weight and improving a variety of related physiological factors, including serum serotonin levels, serum leptin levels, fat oxidation, cholesterol levels, and body mass index, in persons or other mammals, include administering to those persons or other mammals effective amounts of hydroxycitric acid or a combination of hydroxycitric acid, chromium and gymnemic acid, which work synergistically to further to promote healthy body weight and improve these physiological factors.
    Type: Application
    Filed: December 20, 2002
    Publication date: January 22, 2004
    Inventors: Debasis Bagchi, Harry G. Preuss
  • Publication number: 20040013618
    Abstract: A cosmetic formulation, including active principles of strictly natural origin to protect skin against exogenous or endogenous harmful agents as well as to balance again the dermal homeostasis lipids altered by dermatosis and ageing, is characterized by a lipid composition which is close to the human sebum, has a pool of antioxidants similar to those present in sebum and skin, and has anti-inflammatory and anti-free-radical molecules capable of preventing histidine from being decarboxylated and then histamine to be formed.
    Type: Application
    Filed: March 25, 2003
    Publication date: January 22, 2004
    Inventor: Siro Passi
  • Publication number: 20040009243
    Abstract: The present invention relates to a composition which contains as an active ingredient a ginsenoside glycoside (one or more component selected from the group consisting of ginsenoside Rg3, ginsenoside Rg5 and ginsenoside Rh2) or a ginseng extract in combination with a ginsenoside glycoside (one or more component selected from the group consisting of ginsenoside Rg3, ginsenoside Rg5 and ginsenoside Rh2), together with an adjuvant acceptable in the pharmaceutical or sitological field, and is formulated in the preparation form acceptable in the pharmaceutical or food purpose field by a method acceptable in the pharmaceutical or food chemistry. The composition of the present invention has a superior cancer-preventive effect on cancers occurring in individuals and populations having a high risk rate of cancer.
    Type: Application
    Filed: July 8, 2003
    Publication date: January 15, 2004
    Inventors: Taik Koo Yun, Weon Seon Hong
  • Publication number: 20040005370
    Abstract: The present invention relates to a composition including DHEA and/or a chemical or biological precursor or derivative of the latter, characterized in that it additionally comprises at least one metalloproteinase inhibitor.
    Type: Application
    Filed: June 9, 2003
    Publication date: January 8, 2004
    Inventor: Lionel Breton
  • Publication number: 20030235599
    Abstract: The present invention relates to a composition containing a sapogenin, and/or a sapogenin ester, and to the use of a sapogenin and/or a sapogenin ester to manufacture a composition that is suitable for topical application to the skin, and in a method wherein sapogenin and/or a sapogenin ester are used as agents for the of smoothing out wrinkles and fine lines, in particular expression wrinkles and fine lines. The sapogenin may be used/provided in the form of a natural extract containing it. A preferred sapogenin is diosgenin.
    Type: Application
    Filed: March 24, 2003
    Publication date: December 25, 2003
    Applicant: L'OREAL
    Inventor: Isabelle Besne
  • Patent number: 6664288
    Abstract: We have surprisingly discovered that the administration of a G1 and/or S phase drug such as &bgr;-lapachone in combination with a G2/M drug such as a taxame derivative such as paclitaxel resulted in an unexpected greater than additive (i.e., synergistic) reduction in the number of tumors (and tumor volume) as compared with the administration of these agents alone. In addition, no signs of toxicity or weight loss were observed. The present invention relates to a method for treating a mammalian tumor using combinations such as a taxane derivative, preferably paclitaxel, and a &bgr;-lapachone, or a derivative or analog thereof.
    Type: Grant
    Filed: February 7, 2002
    Date of Patent: December 16, 2003
    Assignee: Dana Farber Cancer Institute, Inc.
    Inventors: Arthur B. Pardee, Chiang J. Li, Youzhi Li
  • Publication number: 20030229032
    Abstract: Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo.
    Type: Application
    Filed: December 12, 2002
    Publication date: December 11, 2003
    Applicants: Board of Trustees of MICHIGAN STATE UNIVERSITY, The Regents of the University of California
    Inventors: Robert H. Cichewicz, Muraleedharan G. Nair, James H. McKerrow
  • Publication number: 20030216327
    Abstract: The present invention relates to the use of a sapogenin, chosen from diosgenin and hecogenin, and/or of a plant extract containing at least one of these sapogenins. A preferred use is the treatment of oligoseborrheic dry skin. Another preferred use is the treatment of dry scalp. Compositions containing these sapogenins are also described.
    Type: Application
    Filed: March 24, 2003
    Publication date: November 20, 2003
    Applicant: L'OREAL
    Inventors: Gilles Rubinstenn, Bruno Buan
  • Publication number: 20030203856
    Abstract: The invention provides new isoflavonoid and triterpenoid compounds isolated from a soybean phytochemical concentrate. The new compounds have exhibited cytotoxic activity against selected tumor cell lines. Pharmaceutical compositions comprising the new compounds and methods for use thereof are provided by the invention.
    Type: Application
    Filed: April 19, 2002
    Publication date: October 30, 2003
    Inventors: John P. N. Rosazza, Mohammed Hosny
  • Publication number: 20030198643
    Abstract: An improved method is provided for treating disease states characterized by the existence of pathogenic cell populations. In accordance with the improved method, cell-targeted ligand-immunogen or ligand-hapten complexes are administered to a diseased host to redirect the host immune response to the pathogenic cells which have an accessible binding site for the ligand. The method comprises the step of administering to the host a ligand-immunogen or ligand-hapten conjugate composition comprising a complex of the ligand and the immunogen or hapten wherein the immunogen/hapten is recognized by an endogenous antibody in the host or directly by an immune cell in the host. The improvement to the method comprises the step of using a TH1-biasing adjuvant to enhance the immune response to cell-bound ligand-immunogen or ligand-hapten conjugates.
    Type: Application
    Filed: April 17, 2003
    Publication date: October 23, 2003
    Inventor: Yingjuan Lu
  • Patent number: 6635677
    Abstract: This invention generally relates to novel compositions and methods for the treatment of certain cancers. Additionally, this invention relates to novel compositions and methods to screen drugs for the treatment of certain cancers. Specifically, the invention contemplates that temozolomide and methoxyamine, in combination or in sequence, shall be used as a treatment for certain tumors that are resistant to treatment by temozolomide alone. Additionally, methoxyamine is contemplated for methods of treatment of cancer, wherein methoxyamine is used, in combination or in sequence, with other anticancer drugs or agents.
    Type: Grant
    Filed: February 19, 2002
    Date of Patent: October 21, 2003
    Assignee: Case Western Reserve University
    Inventors: Stanton L. Gerson, Lili Liu
  • Publication number: 20030180339
    Abstract: The invention relates to the use as a sebum regulating agent of a hydrolysed vegetable protein produced by enzymatic hydrolysis, and to compositions comprising a hydrolysed vegetable protein produced by enzymatic hydrolysis for application to the skin to inhibit or regulate sebum production, to inhibit or treat oily skin, or to prevent, inhibit or treat acne. The vegetable protein may be for example a cereal protein such as soy protein, wheat protein or an extract from a tree such as cedar, poplar or mimosa, or from the foliage or from the various stages of the flower, such as the bud. Preferably the vegetable protein has a molecular weight in the region of 100,000 to 500,000 Daltons.
    Type: Application
    Filed: January 10, 2003
    Publication date: September 25, 2003
    Inventors: Alain V. Khaiat, Anna Gomes, Vaishali Bhide
  • Publication number: 20030170329
    Abstract: Highly safe cytokine production inhibitors, agents for protecting and promoting liver function, anti-inflammatory agents and immunosuppressants. Brazilian licorice extract and periandrins, which are constituents thereof, have excellent characteristics of showing effects of inhibiting cytokine production and protecting and promoting liver function, an anti-inflammatory effect and an immunosuppressive effect without any harmful side effects. Thus use of Brazilian licorice extract or periandrins as cytoline production inhibitors makes it possible to inhibit inflammations in various diseases such as rheumatoid arthritis. These substances are also usable as agents for protecting and promoting liver function, anti-inflammatory agents and immunosuppressants. Moreover, foods, cosmetics, sweeteners and food materials containing Brazilian licorice extract exert the effects as described above.
    Type: Application
    Filed: December 13, 2002
    Publication date: September 11, 2003
    Inventors: Minoru Yoshida, Toshihiro Nakayama, Hiroichi Nagai, Munekazu Iinuma
  • Publication number: 20030162731
    Abstract: Improved methods and compositions for protecting plants or seeds from plant diseases are provided. Broadly, the compositions comprise (and preferably consist essentially of) saponin, such as triterpene type saponins extracted from quinoa or quillaja. The methods comprise contacting the portion of the plant (e.g., foliage, shoot, etc.) to be treated with a disease-inhibiting or protective amount of the composition. The compositions can also be used to treat plant seeds or tubers prior to planting thereof, as well as soil adjacent a growing plant. The inventive compositions are particularly useful for the treatment, control and/or prevention of bacterial diseases. The saponins of the invention can be applied as liquids or dry particulates, and are especially suited for the treatment of tomato and potato plants and their respective seeds.
    Type: Application
    Filed: March 28, 2003
    Publication date: August 28, 2003
    Inventor: Joseph M. Dutcheshen
  • Publication number: 20030158097
    Abstract: Novel medicinal compositions aiming at delivering a medicine to a specific site of the large intestine; and preparations for intestinal administration with the use of the same. Namely, medicinal compositions, whereby a medicine can be delivered to a specific site of the large intestine, characterized by containing a P-glycoprotein modifier; and preparations for intestinal administration with the use of the same.
    Type: Application
    Filed: November 21, 2002
    Publication date: August 21, 2003
    Inventors: Norifumi Tanida, Takeshi Goto, Yuji Kurosaki
  • Publication number: 20030152648
    Abstract: A method of suppressing or curbing appetite and treating or preventing obesity comprising administering to a human or other mammal in need of such treatment an effective amount of plant material derived or derivable from plants of the genera Stapelia and Orbea.
    Type: Application
    Filed: November 4, 2002
    Publication date: August 14, 2003
    Inventors: David Gregory Corley, James Miller
  • Patent number: 6605447
    Abstract: Methods for identifying and monitoring increased or decreased levels of inducible nitric oxide synthase in biological samples are provided. A collection device for detecting inducible nitric oxide synthase in biological samples is also provided. Detection of inducible nitric oxide synthase is useful in the diagnosis of inflammatory responses such as infections mediated by bacteria, yeast or viruses, transplant rejection, rheumatoid arthritis, interstitial cystitis and cancer.
    Type: Grant
    Filed: September 14, 1998
    Date of Patent: August 12, 2003
    Assignee: Yale University
    Inventors: Robert M. Weiss, William C. Sessa, Marcia A. Wheeler, Shannon D. Smith
  • Publication number: 20030139355
    Abstract: Disclosed are a medicine for treating an ischemia reperfusion disorder caused by a surgery in a field of orthopaedics, comprising glycyrrhizin and/or its pharmaceutically acceptable salts as an effective component and a treating method using the medicine.
    Type: Application
    Filed: September 10, 2002
    Publication date: July 24, 2003
    Inventors: Nobuaki Nakata, Tetsuo Yamamoto, Atasushi Karino, Kuniaki Kanatani
  • Publication number: 20030133992
    Abstract: A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and administering to them an effective amount of a composition comprising niacin-bound chromium that prevents or reduces the symptoms. Compositions incorporating niacin-bound chromium and additional compounds also are disclosed that are particularly effective in synergistically preventing or reducing these symptoms.
    Type: Application
    Filed: October 4, 2002
    Publication date: July 17, 2003
    Inventors: Debasis Bagchi, Harry G. Preuss, Shil C. Kothari
  • Patent number: 6593303
    Abstract: There are provided the combined use of 4-demethoxy-3′-deamino-3′-aziridinyl-4′-methansulfonyl daunorubicin or 4-demethoxy-N,N-bis(2-chloroethyl)-4′-methansulfonyl daunorubicin and an anti-neoplastic anti-mitotic compound and/or a platinum derivative in the treatment of tumors, as well as in the prevention or treatment of metastasis or in the treatment of tumors by inhibition of angiogenesis.
    Type: Grant
    Filed: August 22, 2001
    Date of Patent: July 15, 2003
    Assignee: Pharmacia & Upjohn, S.p.A.
    Inventors: Cristina Geroni, Marina Ripamonti, Michele Caruso, Antonino Suarato
  • Patent number: 6589939
    Abstract: Camptothecin derivatives of camptothecin of formula (I): wherein the groups R1, R2 and R3 are as defined in the description are disclosed. The compounds of formula (I) are endowed with antitumor activity and show a good therapeutic index. Processes for the preparation of the compounds of formula (I) and their use in the preparation of medicaments useful in the treatment of tumors, viral infections and antiplasmodium falciparum are also disclosed.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: July 8, 2003
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Sergio Penco, Lucio Merlini, Paolo Carminati, Franco Zunino
  • Publication number: 20030108628
    Abstract: Compositions comprising an effective amount of a curcuminoid species and an effective amount of a diterpene lactone species, a triterpene species or derivatives thereof that have a synergistic effect on specific inhibition of inducible COX-2 activity and have minimal effect on COX-1 activity are disclosed. Methods of using the compositions for providing synergistic anti-inflammatory effects are also disclosed.
    Type: Application
    Filed: July 16, 2002
    Publication date: June 12, 2003
    Inventors: John G. Babish, Terrence Howell, Linda Pacioretty
  • Publication number: 20030095974
    Abstract: The present invention relates to an oil in water emulsion vaccine composition. In particular, the present invention relates to a vaccine adjuvant formulation based on oil in water emulsion comprising a metabolisable oil and a saponin, wherein the oil and a saponin are present in a ratio of between 1:1 and 200:1. The invention further relates to methods for preparing the emulsion and its use in medicine.
    Type: Application
    Filed: May 6, 2002
    Publication date: May 22, 2003
    Applicant: SmithKline Beecham Biologicals S.A.
    Inventors: Nathalie Garcon, Patricia Marie Christine Aline Francoise Momin
  • Publication number: 20030092637
    Abstract: The present invention relates to combinations of xylose compounds with other pharmaceutically active compounds, to pharmaceutical compositions comprising said combinations, as well as to use of these combinations for the manufacture of a medicament for treatment of proliferative disorders. In another aspect, the present invention relates to novel xylose compounds, to pharmaceutical compositions comprising said compounds, and to use of these compounds for the manufacture of a medicament or the treatment of proliferative disorders.
    Type: Application
    Filed: October 15, 2002
    Publication date: May 15, 2003
    Inventors: Goran Magnusson, Pia Magnusson Hall, Mattias Belting, Niklas Falk, Lars-Ake Fransson, Katrin Mani
  • Patent number: 6559184
    Abstract: Administration of a pharmaceutical composition in the form of a suppository comprising: (a) a prostaglandin vasodilator; (b) 15-hydroxyprostaglandindehydrogenase inhibitor: and (c) a base material that is solid at room temperature and releases components (a) and (b) when inserted in the urethra, is effective for the treatment of male erectile dysfunction.
    Type: Grant
    Filed: May 3, 2002
    Date of Patent: May 6, 2003
    Assignee: Androsolutions, Inc.
    Inventor: Gary W. Neal
  • Publication number: 20030064938
    Abstract: A composition is prepared by extracting phytochemicals from plant matter. This composition is enriched preferably in isoflavones, lignans, saponins, catechins and phenolic acids. Soy is the preferred source of these chemicals: however, other plants may also be used, such as red clover, kudzu, flax, and cocoa. The composition is a dietary supplement for treatment of various cancers, pre- and post-menstrual syndromes, and various other disorders.
    Type: Application
    Filed: May 1, 2002
    Publication date: April 3, 2003
    Inventors: Mark Empie, Eric Gugger
  • Patent number: 6541462
    Abstract: Cytotoxic tumor therapy in a patient is enhanced by co-administration of sphingomyelin. The invention most likely enhances a tumor cell's ability to undergo ceramide-induced apoptosis by increasing the levels of sphingomyelin in all cellular compartments, thereby providing sufficient substrate for activated sphingomyelinase. A method of treating rheumatoid arthritis also is provided.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: April 1, 2003
    Assignee: Center for Molecular Medicine and Immunology
    Inventor: David Modrak