Oxygen Of The Saccharide Radical Bonded Directly To A Polycyclo Ring System Of Three Or More Carbocyclic Rings Patents (Class 514/33)
  • Patent number: 4886666
    Abstract: A safe pharmaceutical composition for treatment and prevention of infections caused by viruses and increasing immune function. The pharmaceutical composition is composed of four active ingredients: Polysaccharides of Wang Qi, Banlankensu, Yejuhua-flavonoid and Guanzhongsu and method of making the same.
    Type: Grant
    Filed: January 27, 1987
    Date of Patent: December 12, 1989
    Inventor: Yaguang Liu
  • Patent number: 4880802
    Abstract: For treatment of disorders of the central nervous system, the cardiovascular system or the intestinal tract, the new substituted basic 2-aminotetralins of the formula ##STR1## in which R.sup.1 represents hydrogen or alkyl,R.sup.2 represents hydrogen, alkyl or acyl, andR.sup.3 represents quinuclidine or a group of the formula --(CH.sub.2).sub.a --R.sup.4, --CH.sub.2 --CH.dbd.CH--(CH.sub.2).sub.b --R.sup.4, --CH.sub.2 --C.tbd.(CH.sub.2).sub.b --R.sup.4, ##STR2## wherein a denotes a number from 1 to 10,b denotes a number 0, 1, 2, 3 or 4,d denotes a number 2 or 3, andX denotes oxygen, sulphur, or NR.sup.5,and their salts.
    Type: Grant
    Filed: December 8, 1987
    Date of Patent: November 14, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rudolf Schohe, Thomas Glaser, Jorg Traber, George S. Allen
  • Patent number: 4879376
    Abstract: Triterpene saponins of formula ##STR1## wherein R.sub.1 is H or OH and R.sub.2 is a tetrasaccharide, or alternatly pentasaccharide, chain have antiinflammatory, mucolytic and antiedemic activities. Said saponins are isolated from roots and bark of Crossopteryx febrifuga, for instance by precipitating them, in form of a complex with cholesterol or sytosterol, from an alcoholic extract of the vegetal material and by partitioning the precipitate between an apolar solvent, which subtracts the complexing agent and a polar solvent in which saponins are soluble.
    Type: Grant
    Filed: June 26, 1987
    Date of Patent: November 7, 1989
    Assignees: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Inverni Della Beffa Industria Chimico Farmeceutica Derivati Naturali
    Inventors: Piero Foresta, Orlando Ghirardi, Bruno Gabetta, Aldo Cristoni
  • Patent number: 4879118
    Abstract: An antipruritic plaster prepared by spreading a medicament-containing adhesive mass on a backing, said medicament-containing adhesive mass being obtained by dissolving glycyrrhetinic acids in at least one solvent selected from benzyl alcohol, phenethyl alcohol, diphenhydramine, chlorpheniramine, N-methyl-2-pyrrolidone, crotamiton, and lauric acid diethanolamide and uniformly mixing the solution with a plaster base composed of a rubber compound adhesive plaster base, a tackifying agent, and a softener as the necessary components of a plaster base composed of an acrylic resin as the necessary component.
    Type: Grant
    Filed: March 3, 1988
    Date of Patent: November 7, 1989
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Makoto Senuma, Shigeru Kondoh, Tadamasa Kawase, Yoshihiko Nakagawa
  • Patent number: 4849410
    Abstract: Methods for treating mammals to reduce pain, reduce cell proliferation and/or reduce inflammation are described based on administering to the mammals compounds having the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are hydrogen or an acyl group having from 1 to 6 carbon atoms; R.sub.5 is hydrogen, CH.sub.3 or CH.sub.2 OH and R.sub.6 is a hydrocarbon having from 1 to 10 carbon atoms. Natural and synthetic 1,12-seco derivatives with similar utilities are disclosed. Natural and synthetic derivatives are also disclosed where the sugar moiety is attached at the C-10 carbon on the tricyclic diterpene moiety instead of the C-9 carbon.
    Type: Grant
    Filed: August 14, 1987
    Date of Patent: July 18, 1989
    Assignee: The Regents of the University of California
    Inventors: Robert S. Jacobs, William H. Fenical
  • Patent number: 4772589
    Abstract: A stable solution of etoposide in 1-methyl-2-pyrrolidinone is disclosed. The solution can be diluted with a parenteral vehicle to yield an infusion solution containing up to 10 mg/ml etoposide activity without rapid etoposide crystallization. Solutions having etoposide concentration of as high as 500 mg/ml can also be prepared and used to fill gelatin capsules.
    Type: Grant
    Filed: October 29, 1986
    Date of Patent: September 20, 1988
    Assignee: Bristol-Myers
    Inventors: Murray A. Kaplan, Robert K. Perrone, Joseph B. Bogardus
  • Patent number: 4751217
    Abstract: A compound of the formula (I): ##STR1## in which: is a single bond or a double bond,X is hydrogen or hydroxy,n is 0 or 1,Z is ##STR2## when in ring B is a double bond, and, when in ring B is a single bond, Z is wherein W is hydrogen, lower acyl, unsubstituted arylcarbonyl, lower alkyl or substituted arylcarbonyl.These compounds are useful as platelet aggregation inhibitors.
    Type: Grant
    Filed: October 22, 1985
    Date of Patent: June 14, 1988
    Assignees: Nippon Shinyaku Co., Ltd., Takara Shuzo Co., Ltd.
    Inventors: Masanobu Kawamata, Yoji Ezure, Nobutoshi Ojima, Kiyotaka Konno, Teruya Nakamura, Hideyuki Yasuda
  • Patent number: 4745104
    Abstract: Methods for treating mammals to reduce pain, reduce cell proliferation and/or reduce inflammation are described based on administering to the mammals compounds having the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are hydrogen or an acyl residue hydrocarbon having from 1 to 6 carbon atoms, R.sub.5 is hydrogen or CH.sub.2 OH and R.sub.6 is a functionalized hydrocarbon having from 1 to 10 carbon atoms. Natural and synthetic 1,12-seco derivatives of pseudopterosin with similar utilities are disclosed. Synthetic compositions having the above general formula which are useful in the method are disclosed.
    Type: Grant
    Filed: April 15, 1985
    Date of Patent: May 17, 1988
    Assignee: The Regents of the University of California
    Inventors: Robert S. Jacobs, William H. Fenical
  • Patent number: 4713246
    Abstract: A liquid dosage form suitable for oral administration of etoposide which is sufficiently concentrated to be administered in capsule form and which provides improved absorption of the drug relative to prior oral formulations.
    Type: Grant
    Filed: April 2, 1986
    Date of Patent: December 15, 1987
    Assignee: Bristol-Myers Company
    Inventors: Selima Begum, Ismat Ullah, Bernard C. Nunning
  • Patent number: 4628046
    Abstract: This disclosure describes a new antibacterial agent designated LL-C23201.delta., produced in a microbiological fermentation under controlled conditions using a new strain of Streptomyces olivaceo-griseus, sp. nov. and mutants thereof. This new antibacterial agent is active against a variety of microorganisms and thus is useful in inhibiting the growth of such bacteria wherever they may be found.
    Type: Grant
    Filed: June 20, 1983
    Date of Patent: December 9, 1986
    Assignee: American Cyanamid Company
    Inventors: David P. Labeda, Joseph J. Goodman, John H. E. J. Martin, deceased
  • Patent number: 4626503
    Abstract: Antitumor agents LL-D49194.alpha..sub.1, LL-D49194.beta..sub.1, LL-D49194.beta..sub.2, LL-D49194.beta..sub.3, LL-D49194.gamma., LL-D49194.delta., LL-D49194.epsilon., LL-D49194.xi., LL-D49194.eta., LL-D49194.omega., LL-D49194.omega..sub.2 and LL-D49194.omega..sub.3.
    Type: Grant
    Filed: February 14, 1985
    Date of Patent: December 2, 1986
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, Amedeo A. Fantini, David P. Labeda, William M. Maiese, Raymond T. Testa, Donald B. Borders
  • Patent number: 4567164
    Abstract: Tetrocarcins have remarkable and anti-piroplasma activity and anti-malaria activity, and especially useful for preventing or curing piroplasma disease of cattle.
    Type: Grant
    Filed: February 27, 1984
    Date of Patent: January 28, 1986
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Kenjiro Shimada, Masao Otomo, Fusao Tomita, Shingo Ito
  • Patent number: 4524067
    Abstract: This invention is directed to new saponins isolated from soybean seeds, a method for isolating the same and uses of the saponin component of soybeans as an antioxidant for foodstuffs or cosmetics and as an agent for affecting the metabolism in human beings.
    Type: Grant
    Filed: April 21, 1983
    Date of Patent: June 18, 1985
    Assignee: Osaka Chemical Laboratory Co., Ltd.
    Inventors: Shigeru Arichi, Yoshihiro Uchida