Abstract: Disclosed herein are N-alkyl derivatives of antibiotics BU-3608, BU-3608 B, C, D and E as well as the corresponding desxylosyl compounds. These novel compounds are useful as antifungal agents.

Abstract: Novel antitumor epipodophyllotoxin glucoside lactam derivatives are prepared by first converting the lactone ring of the parent compound to the open-chain trans-hydroxy hydrazide, condensing the hydrazide with a carbonyl compound to form the corresponding hydrazone, and finally cyclizing the trans-hydroxy hydrazone using diethylazodicarboxylate and triphenylphosphine.

Abstract: The invention relates to a new application form of low molecular weight alkali metal huminates wherein the waterfree low molecular weight alkali metal huminate is bound to an inorganic, hydrogen bridge forming, carrier material such as titanium dioxide, aluminum oxide, highly dispersed silicium dioxide, or clay.

Abstract: Improvement in method for treating tumors sensitive to treatment with anti-tumor agents employing Norverapamil.

Abstract: The invention relates to a synthetic preparation of alkali metal salts of low molecular weight humic acids wherein multi-valent phenols are oxidized in a weakly alkaline aqueous medium at a temperature in the range of 15.degree. to 40.degree. C. Subsequently, the reaction mixture is adjusted to a pH value ranging between 6.2 and 7.2 and/or buffered. The low molecular alkali metal huminate is then purified through purification means including preparatory chromotography, ultra-filtration, ultra-centrifugation, or electrodialysis and separated from undesirable by-products.

Abstract: Alkali metal or ammonium salts of humic acids, referred to as alkali metal huminates of low molecular weight, obtained by slurrying humic-containing matter in alkaline or ammoniacal aqueous solutions, separating the resulting suspension from coarse solid matter and, through centrifugation, freeing the solution from extremely fine solid materials and high molecular weight huminates. The resulting solution is neutralized and buffered at a pH value ranging from 6.2 to 7.2, and is again purified through centrifugation. From this solution, a low molecular weight fraction is separated. The resulting alkali metal huminates of low molecular weight are useful as therapeutic agents in wound healing and for use in highly effective synthetic mud baths.

Abstract: This invention relates to novel 3'-demethoxy epipodophyllotoxin glucosides, their use as anti-tumor agents, and pharmaceutical compositions thereof.

Abstract: A safe pharmaceutical composition for treatment and prevention of infections caused by viruses and increasing immune function. The pharmaceutical composition is composed of four active ingredients: Polysaccharides of Wang Qi, Banlankensu, Yejuhua-flavonoid and Guanzhongsu and method of making the same.

Abstract: For treatment of disorders of the central nervous system, the cardiovascular system or the intestinal tract, the new substituted basic 2-aminotetralins of the formula ##STR1## in which R.sup.1 represents hydrogen or alkyl,R.sup.2 represents hydrogen, alkyl or acyl, andR.sup.3 represents quinuclidine or a group of the formula --(CH.sub.2).sub.a --R.sup.4, --CH.sub.2 --CH.dbd.CH--(CH.sub.2).sub.b --R.sup.4, --CH.sub.2 --C.tbd.(CH.sub.2).sub.b --R.sup.4, ##STR2## wherein a denotes a number from 1 to 10,b denotes a number 0, 1, 2, 3 or 4,d denotes a number 2 or 3, andX denotes oxygen, sulphur, or NR.sup.5,and their salts.

Abstract: Triterpene saponins of formula ##STR1## wherein R.sub.1 is H or OH and R.sub.2 is a tetrasaccharide, or alternatly pentasaccharide, chain have antiinflammatory, mucolytic and antiedemic activities. Said saponins are isolated from roots and bark of Crossopteryx febrifuga, for instance by precipitating them, in form of a complex with cholesterol or sytosterol, from an alcoholic extract of the vegetal material and by partitioning the precipitate between an apolar solvent, which subtracts the complexing agent and a polar solvent in which saponins are soluble.

Abstract: An antipruritic plaster prepared by spreading a medicament-containing adhesive mass on a backing, said medicament-containing adhesive mass being obtained by dissolving glycyrrhetinic acids in at least one solvent selected from benzyl alcohol, phenethyl alcohol, diphenhydramine, chlorpheniramine, N-methyl-2-pyrrolidone, crotamiton, and lauric acid diethanolamide and uniformly mixing the solution with a plaster base composed of a rubber compound adhesive plaster base, a tackifying agent, and a softener as the necessary components of a plaster base composed of an acrylic resin as the necessary component.

Abstract: Methods for treating mammals to reduce pain, reduce cell proliferation and/or reduce inflammation are described based on administering to the mammals compounds having the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are hydrogen or an acyl group having from 1 to 6 carbon atoms; R.sub.5 is hydrogen, CH.sub.3 or CH.sub.2 OH and R.sub.6 is a hydrocarbon having from 1 to 10 carbon atoms. Natural and synthetic 1,12-seco derivatives with similar utilities are disclosed. Natural and synthetic derivatives are also disclosed where the sugar moiety is attached at the C-10 carbon on the tricyclic diterpene moiety instead of the C-9 carbon.

Abstract: A stable solution of etoposide in 1-methyl-2-pyrrolidinone is disclosed. The solution can be diluted with a parenteral vehicle to yield an infusion solution containing up to 10 mg/ml etoposide activity without rapid etoposide crystallization. Solutions having etoposide concentration of as high as 500 mg/ml can also be prepared and used to fill gelatin capsules.

Abstract: A compound of the formula (I): ##STR1## in which: is a single bond or a double bond,X is hydrogen or hydroxy,n is 0 or 1,Z is ##STR2## when in ring B is a double bond, and, when in ring B is a single bond, Z is wherein W is hydrogen, lower acyl, unsubstituted arylcarbonyl, lower alkyl or substituted arylcarbonyl.These compounds are useful as platelet aggregation inhibitors.

Abstract: Methods for treating mammals to reduce pain, reduce cell proliferation and/or reduce inflammation are described based on administering to the mammals compounds having the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are hydrogen or an acyl residue hydrocarbon having from 1 to 6 carbon atoms, R.sub.5 is hydrogen or CH.sub.2 OH and R.sub.6 is a functionalized hydrocarbon having from 1 to 10 carbon atoms. Natural and synthetic 1,12-seco derivatives of pseudopterosin with similar utilities are disclosed. Synthetic compositions having the above general formula which are useful in the method are disclosed.

Abstract: A liquid dosage form suitable for oral administration of etoposide which is sufficiently concentrated to be administered in capsule form and which provides improved absorption of the drug relative to prior oral formulations.

Abstract: This disclosure describes a new antibacterial agent designated LL-C23201.delta., produced in a microbiological fermentation under controlled conditions using a new strain of Streptomyces olivaceo-griseus, sp. nov. and mutants thereof. This new antibacterial agent is active against a variety of microorganisms and thus is useful in inhibiting the growth of such bacteria wherever they may be found.

Abstract: Antitumor agents LL-D49194.alpha..sub.1, LL-D49194.beta..sub.1, LL-D49194.beta..sub.2, LL-D49194.beta..sub.3, LL-D49194.gamma., LL-D49194.delta., LL-D49194.epsilon., LL-D49194.xi., LL-D49194.eta., LL-D49194.omega., LL-D49194.omega..sub.2 and LL-D49194.omega..sub.3.

Abstract: Tetrocarcins have remarkable and anti-piroplasma activity and anti-malaria activity, and especially useful for preventing or curing piroplasma disease of cattle.

Abstract: This invention is directed to new saponins isolated from soybean seeds, a method for isolating the same and uses of the saponin component of soybeans as an antioxidant for foodstuffs or cosmetics and as an agent for affecting the metabolism in human beings.