Chalcogen Bonded Directly To The Triazole Ring Patents (Class 514/384)
  • Substituted 2-acetamido-5-aryl-1,2,4-triazolones and use thereof
    Patent number: 8202895
    Abstract: The present application relates to new, substituted 2-acetamido-5-aryl-1,2,4-triazolones, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: June 19, 2012
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Ulf Brüggemeier, Chantal Fürstner, Volker Geiβ, Joerg Keldenich, Armin Kern, Martina Delbeck, Peter Kolkhof, Axel Kretschmer, Elisabeth Pook, Carsten Schmeck, Hubert Trübel
  • SEROTONIN REUPTAKE INHIBITORS
    Publication number: 20120142689
    Abstract: In one aspect, the invention relates to compounds of formula I: where Y, R1, R2, n, and Q are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
    Type: Application
    Filed: December 1, 2011
    Publication date: June 7, 2012
    Applicant: THERAVANCE, INC.
    Inventors: Eric L. STANGELAND, Lori Jean VAN ORDEN, Daisuke Roland SAITO
  • Methods Of Modulating Uric Acid Levels
    Publication number: 20120135929
    Abstract: Described herein are compounds useful in the reduction of blood uric acid levels, formulations containing them and methods of making and using them. In some embodiments, a compound disclosed herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.
    Type: Application
    Filed: May 20, 2010
    Publication date: May 31, 2012
    Applicant: Ardea Biosciences Inc.
    Inventors: Martha De La Rosa, Jean-Luc Girardet, Karen Watson
  • Fungicidal mixtures
    Patent number: 8188001
    Abstract: The invention relates to a fungicidal mixture comprising prothioconazole or a salt or adduct thereof with an inorganic acid an organic acid or a metal ion; and at least one further fungicidal compound, selected from the group consisting of thiram, fenoxanil, benthivalicarb, metalaxyl, fludioxonil and prochloraz, in a synergistically effective amount and to methods for controlling harmful fungi, comprising applying the fungicidal mixture.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: May 29, 2012
    Assignee: BASF Aktiengesellschaft
    Inventors: Eberhard Ammermann, Reinhard Stierl, Gisela Lorenz, Ulrich Schöfl, Siegfried Strathmann, Klaus Schelberger, Thomas Christen
  • (?)-enantiomer of the 2-[2-(1-chloro-cyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-2,4-dihydro-[1,2,4]-triazole-3-thione
    Patent number: 8188129
    Abstract: A novel (?)-enantiomer of 2-[2-(1-chloro-cyclopropyl)-3-(2-chloro-phenyl)-2-hydroxypropyl]-2,4-dihydro-[1,2,4]-triazole-3-thione of the formula a process for preparing this novel active compound and its use as microbicide in crop protection and in the protection of materials.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: May 29, 2012
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rolf Grosser, Manfred Jautelat, Astrid Mauler-Machnik, Stefan Dutzmann, Gerd Hanβler, Klaus Stenzel
  • Triazole compounds that modulate HSP90 activity
    Patent number: 8188075
    Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of treating or inhibiting angiogenesis in a subject in need thereof and methods for blocking, occluding, or otherwise disrupting blood flow in neo vasculature, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: May 29, 2012
    Assignee: Synta Pharmaceuticals Corp.
    Inventors: Weiwen Ying, Kevin Foley
  • POLYMORPHIC, CRYSTALLINE AND MESOPHASE FORMS OF SODIUM 2-(5-BROMO-4-(4-CYCLOPROPYLNAPHTHALEN-1-YL)-4H-1,2,4-TRIAZOL-3-YLTHIO) ACETATE, AND USES THEREOF
    Publication number: 20120129903
    Abstract: Crystalline polymorphs and solid mesophase forms of sodium 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetate are described. In addition, pharmaceutical compositions and uses of such compositions for the treatment of a variety of diseases and conditions are provided.
    Type: Application
    Filed: January 5, 2011
    Publication date: May 24, 2012
    Applicant: Ardea Biosciences, Inc.
    Inventors: Irina Zamansky, Jean-Luc Girardet, Gabriel Galvin
  • PRESELECTION OF SUBJECTS FOR THERAPEUTIC TREATMENT BASED ON HYPOXIC STATUS
    Publication number: 20120128665
    Abstract: The present invention provides methods for the preselection of a subject for therapeutic treatment with an agent based on modulated levels of hypoxia in cancerous cells in the subject. In one embodiment, the invention provides methods for the preselection of a subject for therapeutic treatment with an agent based on modulated levels of lactate dehydrogenase (LDH) in a cell, e.g., a cancerous cell. The invention also provides methods for treating cancer in a subject by administering an effective amount of an agent to the subject, wherein the subject has been selected based on a modulated level of hypoxia. The invention further provides kits to practice the methods of the invention.
    Type: Application
    Filed: November 18, 2011
    Publication date: May 24, 2012
    Applicant: SYNTA PHARMACEUTICALS CORP.
    Inventors: Ronald K. Blackman, Vojo Vukovic
  • 4-SUBSTITUTED-3-PHENYLSULFANYLMETHYL-BICYCLO[3.1.0]HEXANE COMPOUNDS AS mGluR 2/3 ANTAGONISTS
    Publication number: 20120129902
    Abstract: A mGlu2/3 receptor antagonist of the formula: its uses, and methods for its preparation are described.
    Type: Application
    Filed: November 15, 2011
    Publication date: May 24, 2012
    Applicant: ELI LILLY AND COMPANY
    Inventors: Stephon Cornell SMITH, Renhua LI, Charles Howard MITCH, Tatiana Natali VETMAN
  • COMPOSITIONS AND METHODS FOR PROMOTING VASCULAR BARRIER FUNCTION AND TREATING PULONARY FIBROSIS
    Publication number: 20120129757
    Abstract: Active agents and compositions that promote barrier function or that inhibit permeability of the vascular endothelium associated with pulmonary inflammation are described.
    Type: Application
    Filed: December 11, 2009
    Publication date: May 24, 2012
    Inventors: Dean Li, Nyall London, Weiquan Zhu
  • Triazole compounds that modulate HSP90 activity
    Patent number: 8183384
    Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: May 22, 2012
    Assignee: Synta Pharmaceuticals Corp.
    Inventors: Dinesh U. Chimmanamada, Weiwen Ying, Teresa Przewloka, Shijie Zhang, Kevin Foley, Zhenjian Du, Dan Zhou, Shuzhen Qin
  • TRIZAOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY
    Publication number: 20120122869
    Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
    Type: Application
    Filed: January 13, 2012
    Publication date: May 17, 2012
    Inventors: Weiwen Ying, David James, Shijie Zhang, Junghyun Chae, Teresa Przewloka, Howard P. Ng, Hao Li, Zachary Demko, Dinesh U. Chimmanamada, Chi-wan Lee, Zhenjian Du, Kevin Foley, Minghu Song, Lijun Sun, Keizo Koya, Dan Zhou, Shuzhen Qin
  • Compounds, compositions and methods of using same for modulating uric acid levels
    Patent number: 8173690
    Abstract: Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of making and using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: May 8, 2012
    Assignee: Ardea Biosciences, Inc.
    Inventors: Esmir Gunic, Jean-Luc Girardet, Jean-Michel Vernier, Martina E. Tedder, David A. Paisner
  • Use of Fungicidal Active Substances For Controlling Mycoses on Plants of the Palm Family
    Publication number: 20120108580
    Abstract: The present invention relates to the use of specific fungicidal active substances, alone or in combination, for controlling mycoses in plants of the palm family and to a method for using said specific fungicidal active substances for controlling said mycoses in the field of plant protection and the protection of materials.
    Type: Application
    Filed: April 14, 2011
    Publication date: May 3, 2012
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Dirk Ebbinghaus, Kerstin Hesse, Marie-Claire Grosjean-Cournoyer, David Chamberlin
  • Antifungal 1,2,4-triazolyl Derivatives
    Publication number: 20120108422
    Abstract: The present invention relates to novel triazole compounds of the formulae I and II as defined below which carry a sulfur substituent, to agricultural compositions containing them, to their use as fungicides and to intermediate compounds used in the method of producing them.
    Type: Application
    Filed: June 17, 2010
    Publication date: May 3, 2012
    Applicant: BASF SE
    Inventors: Jens Renner, Jochen Dietz, Alice Glaettli, Thomas Grote, Wassilios Grammenos, Bernd Mueller, Jan Klaas Lohmann, Sarah Ulmschneider, Marianna Vrettou-Schultes
  • VIRAL POLYMERASE INHIBITORS
    Publication number: 20120101091
    Abstract: The present application provides compounds of formula I wherein X, Y, R2, n, R5 and R6 are defined herein, useful as inhibitors of the hepatitis C virus NS5B polymerase The present application also provides pharmaceutical compositions containing said compounds, methods of using said compounds as pharmaceuticals alone or with other antiviral agent in the treatment of a hepatitis C viral infection in a mammal having or at risk of having the infection.
    Type: Application
    Filed: October 1, 2009
    Publication date: April 26, 2012
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Pierre Beaulieu, Pierre Bonneau, René Coulombe, Pasquale Forgione, James Gillard, Araz Jakalian, Jean Rancourt
  • Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors
    Patent number: 8163788
    Abstract: The invention relates to a pharmaceutical composition and the use thereof, wherein the pharmaceutical composition contains compounds selected from a group of general formulas (5), (6), (7) and (8) and/or enantiomers, diastereomers or the pharmaceutically acceptable salts thereof. The pharmaceutical composition is used for treating autoimmune and tumoral diseases and/or for immunosuppresion.
    Type: Grant
    Filed: November 18, 2005
    Date of Patent: April 24, 2012
    Assignee: Rheinische Friedrich-Wilhelms Universitat Bonn
    Inventors: Michael Famulok, Waldemar Kolanus, Markus Hafner, Imke Grune, Barbara Tappertzhofen, Mirko Theis
  • TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE INHIBITORS AND USES THEREOF FOR TREATING VASCULAR CALCIFICATION
    Publication number: 20120095044
    Abstract: Disclosed herein are compounds that are tissue-nonspecific alkaline phosphatase inhibitors. The disclosed compounds are used to treat, prevent, or abate vascular calcification, arterial calcification and other cardiovascular diseases.
    Type: Application
    Filed: December 7, 2011
    Publication date: April 19, 2012
    Inventors: Jose Luis Millan, Eduard Sergienko
  • FUNGICIDAL MIXTURES
    Publication number: 20120088665
    Abstract: The present invention relates to fungicidal mixtures comprising, as active components, 1) sulfur-containing triazole compounds I as described in the application, and 2) a fungicidal compound II, where the compounds II of component 2 are selected from among the compounds described in the application, and to the use of the fungicidal mixtures for controlling phytopathogenic fungi and to compositions comprising them.
    Type: Application
    Filed: June 11, 2010
    Publication date: April 12, 2012
    Applicant: BASF SE
    Inventors: Jochen Dietz, Thomas Grote, Egon Haden, Bernd Müller, Jan Klaas Lohmann, Jens Renner, Sarah Ulmschneider, Alice Glättli, Marianna Vrettou-Schultes, Wassilios Grammenos
  • TISSUE-NONSPECIFIC ALKALINE PHOSPHATASE (TNAP): A THERAPEUTIC TARGET FOR ARTERIAL CALCIFICATION
    Publication number: 20120088771
    Abstract: This invention relates generally to the field of mineralization, and specifically to the role of TNAP in regulating the levels of extracellular inorganic pyrophosphate. The invention provides methods for modulating the activity of TNAP activity; methods for screening for modulators of TNAP activity; modulators of TNAP activity; and methods for treating pathologic conditions known of suspected to be affected by modulation of TNAP activity.
    Type: Application
    Filed: October 11, 2011
    Publication date: April 12, 2012
    Inventor: Jose Luis Millan
  • Antifungal 1,2,4-triazolyl Derivatives
    Publication number: 20120088660
    Abstract: The present invention relates to novel triazole compounds of the formulae I and II as defined below which carry a sulfur substituent, to agricultural compositions containing them, to their use as fungicides and to intermediate compounds used in the method of producing them.
    Type: Application
    Filed: June 17, 2010
    Publication date: April 12, 2012
    Applicant: BASF SE
    Inventors: Jens Renner, Jochen Dietz, Alice Glaettli, Thomas Grote, Wassilios Grammenos, Bernd Mueller, Jan Klaas Lohmann, Sarah Ulmschneider, Marianna Vrettou-Schultes
  • FUNGICIDAL MIXTURES
    Publication number: 20120088662
    Abstract: The present invention relates to fungicidal mixtures comprising, as active components, 1) azolylmethyloxiranes of the general formula I in which the variables have the meanings described in the application, and 2) a fungicidal compound II, where the compounds II of component 2 are selected from among the compounds described in the application, and to the use of the fungicidal mixtures for controlling phytopathogenic fungi and to the compositions comprising them.
    Type: Application
    Filed: June 11, 2010
    Publication date: April 12, 2012
    Applicant: BASF SE
    Inventors: Jochen Dietz, Egon Haden, Jens Renner, Sarah Ulmschneider, Alice Glättli, Marianna Vrettou-Schultes, Silke Stolz
  • FUNGICIDAL MIXTURES
    Publication number: 20120088661
    Abstract: The present invention relates to fungicidal mixtures comprising, as active components, 1) azolylmethyloxiranes of the general formula I wherein the variables have the meanings described in the application, 2) a fungicidal compound II, and 3) optionally a further fungicidal compound II, where the compounds II of components 2 and 3 independently of one another are selected from the group consisting of the compounds described in the application, with the proviso that components 2 and 3 are not identical, and to the use of the fungicidal mixtures for controlling phytopathogenic fungi and to the compositions comprising them.
    Type: Application
    Filed: June 15, 2010
    Publication date: April 12, 2012
    Applicant: BASF SE
    Inventors: Jochen Dietz, Egon Haden, Jens Renner, Sarah Ulmschneider, Alice Glättli, Marianna Vrettou-Schultes, Silke Stolz
  • Antifungal 1,2,4-triazolyl derivatives having a 5-sulfur subtituent
    Publication number: 20120088664
    Abstract: The present invention relates to novel triazole compounds of the formulae I and II as defined below which carry a sulfur substituent, to agricultural compositions containing them, to their use as fungicides and to intermediate compounds used in the method of producing them.
    Type: Application
    Filed: June 17, 2010
    Publication date: April 12, 2012
    Applicant: BASF SE
    Inventors: Jens Renner, Jochen Dietz, Alice Glaettli, Thomas Grote, Wassilios Grammenos, Bernd Mueller, Jan Klaas Lohmann, Sarah Ulmschneider, Marianna Vrettou-Schultes
  • Triazole Compounds Carrying a Sulfur Substituent
    Publication number: 20120088663
    Abstract: The present invention relates to novel triazole compounds of the formulae I and II as defined below which carry a sulfur substituent, to agricultural compositions containing them, to their use as fungicides and to intermediate compounds used in the method of producing them.
    Type: Application
    Filed: June 17, 2010
    Publication date: April 12, 2012
    Applicant: BASF SE
    Inventors: Sarah Uluschneider, Jochen Dietz, Jens Renner, Thomas Grote, Wassilios Grammenos, Bernd Mueller, Jan Klaas Lohmann, Marianna Vrettou-Schultes, Richard Riggs
  • Sulfonamides as TRPM8 modulators
    Patent number: 8153682
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
    Type: Grant
    Filed: July 18, 2008
    Date of Patent: April 10, 2012
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Shawn T. Branum, Raymond W. Colburn, Scott L. Dax, Christopher M. Flores, Michele C. Jetter, Yi Liu, Donald Ludovici, Mark J. Macielag, Jay M. Matthews, James J. McNally, Laura M. Reaney, Ronald K. Russell, Ning Qin, Christopher Teleha, Kenneth M. Wells, Scott C. Youells, Mark A. Youngman
  • Antifungal 1,2,4-Triazolyl Derivatives Having a 5-Sulfur Substituent
    Publication number: 20120077676
    Abstract: The present invention relates to novel triazole compounds of the formulae I and II as defined below which carry a sulfur substituent, to agricultural compositions containing them, to their use as fungicides and to intermediate compounds used in the method of producing them.
    Type: Application
    Filed: June 11, 2010
    Publication date: March 29, 2012
    Applicant: BASF SE
    Inventors: Jochen Dietz, Thomas Grote, Egon Haden, Bernd Mueller, Jan Klaas Lohmann, Jens Renner, Sarah Ulmschneider, Alice Glaetli, Marianna Vrettou-Schultes, Wassilios Grammenos
  • HSP90 Inhibitors for Treating Non-Small Cell Lung Cancer in Wild-Type EGFR and/or KRAS Patients
    Publication number: 20120064175
    Abstract: Provided is a method for treating non-small cell lung cancer with wild-type EGFR gene and/or KRAS gene by administering to a subject in need thereof, an effective amount of a triazolone compound according to the following formula: a tautomer, or a pharmaceutically acceptable salt thereof, wherein the variables in the structural formulae are defined herein.
    Type: Application
    Filed: September 13, 2011
    Publication date: March 15, 2012
    Inventors: Vojo Vukovic, Florentina Teofilovici
  • TRIAZOLE DERIVATIVES AS VASOPRESSIN-RECEPTOR INHIBITORS FOR TREATING CARDIAC INSUFFICIENCY
    Publication number: 20120053218
    Abstract: The present application relates to novel substituted phenylalanine derivatives, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.
    Type: Application
    Filed: March 9, 2010
    Publication date: March 1, 2012
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Ulf Brüggemeier, Chantal Fürstner, Volker Geiß, Joerg Keldenich, Armin Kern, Martina Delbeck, Peter Kolkhof, Axel Kretschmer, Elisabeth Pook, Carsten Schmeck, Hubert Trübel
  • Chemically Stable Dispersions of Prothioconazole and Processes for Preparing Them
    Publication number: 20120046328
    Abstract: Chemically stable aqueous dispersions of prothioconazole and processes for preparing them are provided. The dispersions comprise prothioconazole present in an aqueous medium, and a sulfur-containing compound present in an amount effective to render the dispersion chemically stable.
    Type: Application
    Filed: August 9, 2011
    Publication date: February 23, 2012
    Inventors: Fred C. Rosa, Tai-Teh Wu
  • Use of fungicidal compound compositions for controlling certain rust fungi
    Publication number: 20120035165
    Abstract: The present invention relates to the use of a fungicidal composition comprising at least one carboxamide and at least one further compound selected from strobilurins or from triazoles, for controlling certain rust fungi, such as soy bean rust and coffee rust, in crop protection.
    Type: Application
    Filed: August 21, 2009
    Publication date: February 9, 2012
    Applicant: Bayer CropScience AG
    Inventors: Karl-Wilhelm Münks, Heiko Rieck, Ulrike Wachendorff-Neumann, Ingo Wetcholowsky, Jose Augusto Geraldes
  • PESTICIDE COMPOSITIONS OF MESO-SIZED PARTICLES WITH ENHANCED ACTIVITY
    Publication number: 20120035054
    Abstract: The present disclosure relates to pesticide compositions consisting of meso-sized particles in combination with certain adjuvants such as built-in adjuvants which are added directly to the formulation or to an aqueous dilution of the formulation such as tank-mix adjuvants, to provide enhanced effectiveness for the control of agricultural pests. Mesoparticle compositions containing such adjuvants have been found to provide improved effectiveness compared to mesoparticle compositions not containing such adjuvants or to conventional formulations.
    Type: Application
    Filed: August 3, 2011
    Publication date: February 9, 2012
    Applicant: DOW AGROSCIENCES LLC
    Inventors: Robert J. Ehr, Thomas H. Kalantar, Lei Liu, Dale C. Schmidt, Qiang Zhang, Min Zhao
  • SMALL MOLECULE MODULATORS OF CELL ADHESION
    Publication number: 20120022083
    Abstract: Compounds, particularly compounds having activity as modulators of cadherin-mediated cell adhesion having the following structure: or a pharmaceutically acceptable salt, stereoisomer or prodrug thereof, wherein R1, R2, R3, R4, R5, R6, A, X, Y, Z, m and n are as defined herein. Methods associated with preparation and use of the same, as well as pharmaceutical compositions containing the same, are also disclosed.
    Type: Application
    Filed: February 9, 2011
    Publication date: January 26, 2012
    Applicant: ADHEREX TECHNOLOGIES, INC.
    Inventors: Mukur Gupta, Brian Huber, Orest W. Blaschuk
  • Synergistic fungicidal active substance combinations
    Publication number: 20120015910
    Abstract: Novel active compound combinations comprising a carboxamide of the general formula (I) (group 1) in which A, R1, R2 and R3 are as defined in the description, and the active compound groups (2) to (23) listed in the description have very good fungicidal properties.
    Type: Application
    Filed: September 23, 2011
    Publication date: January 19, 2012
    Applicant: Bayer CropScience AG
    Inventors: Ulrike Wachendorff-Neumann, Peter Dahmen, Ralf Dunkel, Hans-Ludwig Elbe, Anne Suty-Heinze, Heiko Rieck
  • Compounds useful in therapy
    Patent number: 8093400
    Abstract: The present invention provides compounds of formula (I), or pharmaceutically acceptable derivatives thereof wherein the variables Z, Q, Ring A, V, X, Y and Y? are as defined herein, and pharmaceutical compositions comprising these compounds. The compounds of formula (I) and pharmaceutical compositions comprising them are useful for treating a disorder for which a V1a antagonist is indicated, in particular, dysmenorrhoea.
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: January 10, 2012
    Assignee: Pfizer Inc.
    Inventors: Justin Stephen Bryans, Patrick Stephen Johnson, Lee Richard Roberts, Thomas Ryckmans
  • METHOD FOR TREATING NON-HODKIN'S LYMPHOMA
    Publication number: 20110319404
    Abstract: The present invention relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating non-Hodgkin's lymphoma, in a subject in need thereof.
    Type: Application
    Filed: September 7, 2011
    Publication date: December 29, 2011
    Inventor: Kevin Foley
  • COMPOUND WITH AGITATION EFFECT ON PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR. PROCESS FOR ITS PREPARATION AND USE THEREOF
    Publication number: 20110319458
    Abstract: The present invention provides a novel compound of formula I, which has an agitation effect on the peroxisome proliferator-activated receptor subtype ? (PPAR?), to a pharmaceutical composition comprising the compound, to a process for preparation of the compound and to use of the compound in the manufacture of a medicament for treating or preventing a disease which could be treated or prevented by activating PPAR? thereof, said disease is one or more from the group comprising metabolic syndrome, obesity, dyslipidemia, pathoglycemia, insulin resistance, senile dementia and tumors. The present invention also relates to a new intermediate used in the preparation of the novel compound and a process for preparation of the intermediate.
    Type: Application
    Filed: August 7, 2009
    Publication date: December 29, 2011
    Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Chunhua Jin, Xiaoyu Liu, Zhenliang Chen, Xiaohe Zheng, Shoufeng Ming
  • METHODS AND COMPOSITIONS FOR TREATING ANXIETY
    Publication number: 20110319417
    Abstract: Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.
    Type: Application
    Filed: August 6, 2009
    Publication date: December 29, 2011
    Inventors: Jayhong Chong, Christopher Fanger, Magdalene M. Moran, Elisha Singer, Timothy Strassmaier, Howard Ng
  • Compounds and compositions and methods of use
    Patent number: 8084483
    Abstract: Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: December 27, 2011
    Assignee: Ardea Biosciences, Inc.
    Inventors: Barry D. Quart, Jean-Luc Girardet, Esmir Gunic, Li-Tain Yeh
  • Compositions and kits comprising a fungicidal triazole and an alkoxylated alcohol, and their uses
    Patent number: 8084482
    Abstract: The present invention relates to compositions comprising (a1) a fungicidal triazole; and (b1) ethoxylated 2-propylheptanol having a mole average degree of ethoxylation from 7.5 to 8.5, to kits comprising the triazole and alcohol alkoxylate in separate containers, as well as to their uses in the agricultural field. The present invention also relates to use of ethoxylated 2-propylheptanol having a degree of ethoxylation from 7.5 to 8.5 as adjuvant and surfactant safener.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: December 27, 2011
    Assignee: BASF SE
    Inventors: Ted R. Bardinelli, Charles W. Finch
  • METHOD FOR TREATING PROLIFERATIVE DISORDERS ASSOCIATED WITH PROTOONCOGENE PRODUCTS
    Publication number: 20110301212
    Abstract: The present invention relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating Bcr-Abl, FLT-3, EGFR, c-Kit, B-raf, and NPM-ALK associated cancers, in a subject in need thereof.
    Type: Application
    Filed: August 16, 2011
    Publication date: December 8, 2011
    Inventors: Zhenjian Du, Kevin Foley
  • NOVEL COMPOUNDS AND COMPOSITIONS AND METHODS OF USE
    Publication number: 20110293719
    Abstract: Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.
    Type: Application
    Filed: June 30, 2011
    Publication date: December 1, 2011
    Applicant: Ardea Biosciences, Inc.
    Inventors: Barry D. Quart, Jean-Luc Girardet, Esmir Gunic, Li-Tain Yeh
  • Triazole compounds that modulate Hsp90 activity
    Patent number: 8053456
    Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: November 8, 2011
    Assignee: Synta Pharmaceuticals Corp.
    Inventors: Lijun Sun, Weiwen Ying, Junghyun Chae, Teresa Przewloka, Shijie Zhang, Dinesh U. Chimmanamada, Kevin Foley, Zhenjian Du, Hao Li, David James, Howard P. Ng, Zachary Demko, Dan Zhou, Shuzhen Qin
  • COMPOSITION FOR CONTROLLING PLANT DISEASES AND METHOD FOR CONTROLLING PLANT DISEASES
    Publication number: 20110269623
    Abstract: PROBLEM There are provided a composition for controlling plant diseases and a method for controlling plant diseases having excellent control effect for plant diseases. SOLUTION A composition for controlling plant diseases comprising, as active ingredients, a compound represented by formula (1), wherein X1 represents a methyl group, a difluoromethyl group or an ethyl group; X2 represents a methoxy group or a methylamino group; and X3 represents a phenyl group, a 2-methylphenyl group or a 2,5-dimethylphenyl group, and at least one azole compound selected from the group consisting of bromuconazole, cyproconazole, difenoconazole, fenbuconazole, fluquinconazole, hexaconazole, imibenconazole, ipconazole, myclobutanil, prothioconazole, simeconazole, tetraconazole, triticonazole and metconazole.
    Type: Application
    Filed: November 20, 2009
    Publication date: November 3, 2011
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Masanao Takaishi, Masato Soma
  • NOVEL COMPOUNDS AND COMPOSITIONS AND METHODS OF USE
    Publication number: 20110268801
    Abstract: Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.
    Type: Application
    Filed: June 30, 2011
    Publication date: November 3, 2011
    Applicant: Ardea Biosciences, Inc.
    Inventors: Barry D. Quart, Jean-Luc Girardet, Esmir Gunic, Li-Tain Yeh
  • CRTH2 receptor ligands for medicinal uses
    Publication number: 20110269763
    Abstract: Compounds of formula (I) are useful for the treatment of disease responsive to modulation of CRTH2 receptor activity, such as asthma, rhinitis, allergic airway syndrome, and allergic rhinobronchitis: wherein A represents a carboxyl group —COOH, or a carboxyl bioisostere; A1 is hydrogen or methyl; ring Ar1 is an optionally substituted phenyl ring or 5- or 6-membered monocyclic heteroaryl ring, in which AA1CHO— and L2 are linked to adjacent ring atoms; rings Ar2, Ar3 each independently represent a phenyl or 5- or 6-membered monocyclic heteroaryl ring, or a bicyclic ring system consisting of a 5- or 6-membered carbocyclic or heterocyclic ring which is benz-fused or fused to a 5- or 6-membered monocyclic heteroaryl ring, said ring or ring system being optionally substituted; t is 0 or 1; L2 and L3 are linker radicals as defined in the description.
    Type: Application
    Filed: June 2, 2011
    Publication date: November 3, 2011
    Applicant: 7TM Pharma A/S
    Inventors: Trond Ulven, Thomas Frimurer, Øystein Rist, Evi Kostenis, Thomas Högberg, Jean-Marie Receveur, Marie Grimstrup
  • Fungicidal active ingredient combination
    Patent number: 8044036
    Abstract: An active-compound combination of has very good fungicidal properties.
    Type: Grant
    Filed: May 24, 2006
    Date of Patent: October 25, 2011
    Assignee: Bayer Cropscience AG
    Inventors: Anne Suty-Heinze, Burkhard Schütz
  • Mixture comprising strobilurins and ethylene modulators
    Patent number: 8044084
    Abstract: The present invention relates to mixtures comprising a) a compound of the formula I in which X, m, Q and a are as defined in the description and b) one or more ethylene modulators (II) selected from the group consisting of: inhibitors of ethylene biosynthesis which inhibit the conversion of S-adenosyl-L-methionine into 1-aminocyclopropane-1-carboxylic acid (ACC), inhibitors of ethylene biosynthesis which block the conversion of ACC into ethylene, or inhibitors of ethylene action, and also to compositions comprising them and to their use for controlling harmful fungi.
    Type: Grant
    Filed: November 5, 2004
    Date of Patent: October 25, 2011
    Assignee: BASF SE
    Inventors: Wilhelm Rademacher, John S. Harden, Dan E. Westberg, Joseph E. Zawierucha, Thomas J. Holt, Hendrik Ypema, Ted R. Bardinelli, Albert C. Everson, Edson Begliomini
  • TRIAZOLIUM AND IMIDAZOLIUM SALTS AND USES THEREOF
    Publication number: 20110257235
    Abstract: The present disclosure relates to certain new and known triazolium and/or imidazolium salts and to their therapeutic use, for example in methods of treating or preventing an infection by a Plasmodium or Babesia parasite in a subject in need thereof. The triazolium and imidazolium salts are compounds of the Formula (I) or (II): wherein R1-R4, R1?-R3?, R8-R11, X, X?, X?, Y, Y? and Y? are as defined in the disclosure.
    Type: Application
    Filed: September 4, 2009
    Publication date: October 20, 2011
    Inventors: Ian E. Crandall, Walter A. Szarek, Jason Z. Vlahakis
  • NITROGEN HETEROCYCLE DERIVATIVES AS PROTEASOME MODULATORS
    Publication number: 20110257176
    Abstract: A method for treating and/or ameliorating and/or preventing a disease or a disorder, the method comprising administering to an individual in need thereof at least one nitrogen heterocycle derivative of formula (I): The at least one nitrogen heterocycle derivative may also be used as a proteasome activity modulator in the manufacture of a pharmaceutical composition intended to prevent and/or treat a disease condition mediated by the proteasome activity.
    Type: Application
    Filed: April 4, 2011
    Publication date: October 20, 2011
    Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE RENNES 1, UNIVERSITE PARIS DIDEROT, UNIVERSITE PIERRE ET MARIE CURIE
    Inventors: Bruno VILLOUTREIX, Michele REBOUD-RAVAUX, Nicolas BASSE, Joelle VIDAL, Matthieu MONTES