N-c(=x)x Containing (x Is Chalcogen) Doai Patents (Class 514/476)
  • Patent number: 5185368
    Abstract: Compounds of the formula ##STR1## in which R is alkyl having up to 4 carbon atoms, n has an average value of at least 9, X is a radical of the formula --C(.dbd.O)--(NH--SO.sub.2).sub.m -- in which m is 0 or 1 and, if m is 1, the carbonyl group may be bonded to the oxygen atom or to the nitrogen atom, and each of the radicals A.sub.1, A.sub.2 and A.sub.3, independently of the others, is hydrogen or an acyl radical, and salts of salt-forming compounds of formula I, as well as metal complexes of compounds of formula I, in which A.sub.1, A.sub.2 and A.sub.3, are hydrogen can be used as metal chelators and as auxiliaries in diagnosis.
    Type: Grant
    Filed: July 20, 1988
    Date of Patent: February 9, 1993
    Assignee: Ciba-Geigy Corporation
    Inventors: Heinrich Peter, Theophile Moerker
  • Patent number: 5180420
    Abstract: The water dispersible granule of the present invention contains (a) a pesticidal active ingredient which is solid at room temperature, (b) an anionic surface active agent, and (c) a kaolin series clay having a volume median diameter of 2 .mu.m or more, and it exhibits a good disintegrability-in-water and a high dispersion stability.
    Type: Grant
    Filed: March 11, 1991
    Date of Patent: January 19, 1993
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Yasuyuki Katayama, Yasuhiko Ishimoto, Fumio Horide, Shigenori Tsuda, Fumio Nishioka
  • Patent number: 5155131
    Abstract: Alkylthioalkylamine carbamic acid derivatives are prepared which correspond to the formula: ##STR1## wherein R and R.sub.1 are both independently alkyl groups containing from 6 to 16 carbon atoms, and m and n are both independently integers of from 2 to 3. Compositions containing these compounds inhibit the growth of organisms such as bacteria, yeast, fungi, mold, algae, mollusks, hydroids, or tunicates on surfaces.
    Type: Grant
    Filed: January 22, 1992
    Date of Patent: October 13, 1992
    Assignee: The Dow Chemical Company
    Inventors: Attila G. Relenyi, Charles D. Gartner, Richard W. Walter
  • Patent number: 5141956
    Abstract: Ethyl 2-[4-(3-chlorophenoxy)phenoxy]ethylcarbamate is suitable controlling phytophagous cicadas in rice crops and fruit pests such as leaf rollers, citrus fruit pests such as scale insects, and vegetable and cotton pests such as white flies and noctuids.
    Type: Grant
    Filed: June 19, 1990
    Date of Patent: August 25, 1992
    Assignee: Ciba-Geigy Corporation
    Inventor: Friedrich Karrer
  • Patent number: 5116992
    Abstract: The invention relates to glycerol derivatives of general formulae Ia, Ib and Ic ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, A and Y stand for various substituents, to a preparation process of said compounds and to therapeutical compositions containing the same.
    Type: Grant
    Filed: December 19, 1990
    Date of Patent: May 26, 1992
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Pierre Braquet, Colette Broquet, Benedicte Vandamme, Paola Principe-Nicolas
  • Patent number: 5110822
    Abstract: A synergistic antimicrobial composition comprising 4,5-dichloro-2-n-octyl-3-isothiazolone or 2-methyl-3-isothiazolone and ferric dimethyldithiocarbamate, in a ratio to each other which exhibits synergism is disclosed.
    Type: Grant
    Filed: January 3, 1991
    Date of Patent: May 5, 1992
    Assignee: Rohm and Haas Company
    Inventors: Samuel E. Sherba, Raj J. Mehta, Barry C. Lange
  • Patent number: 5100915
    Abstract: A method is provided for stabilizing alkylenebisdithiocarbamates, such as 1,2-ethylenebisdithiocarbamates (EBDC), by mixing the EBDC in the presence of water with a hydroxymethane sulfinate (HMS) which degrades to formaldehyde to reduce the content of ethylenethiourea (ETU) in the EBDC. The HMS and sulfate by-product from the formaldehyde formation also act as reducing agents to inhibit further ETU formation by oxidative decomposition of EBDC. The hydroxymethane sulfinate is preferably added in an amount of about 0.1 to 5 weight percent based upon the EBDC, and the aqueous reaction mixture is then preferably dried under vacuum. Co-polymerization agents, such as hydroquinone or melamine, may also be added to further reduce and inhibit ETU content and formation.
    Type: Grant
    Filed: June 6, 1990
    Date of Patent: March 31, 1992
    Assignee: Pennwalt France S.A.
    Inventors: Pieter Kool, Pieter C. Diepenhorst, Jacobus A. M. Nouws
  • Patent number: 5077314
    Abstract: A method is disclosed for the containment and controlled release of and the substantial reduction of the leaching from the site of application of agricultural chemicals. In the disclosed method, the agricultural chemicals are applied to the soil dispersed in an aqueous gel-forming composition. Novel compositions of the agricultural chemicals dispersed in aqueous gel-forming compositions are also disclosed.
    Type: Grant
    Filed: May 25, 1990
    Date of Patent: December 31, 1991
    Assignee: Pfizer Inc.
    Inventors: Judson C. Philips, Hazen L. Hoyt, IV, Christopher A. Macri, Wesley L. Miller, John J. O'Neill
  • Patent number: 5075332
    Abstract: Crop yields are significantly enhanced by treating soil or other plant growing media with a fungicidally or pesticidally effective amount of metham, the fungicidally or pesticidally effective amount being insufficient to significantly retard growth of a plant. In the practice of the invention, the soil or growing media surrounding roots of growing plants is treated with metham by dripping an aqueous solution of metham onto the media, by injecting the aqueous solution into the soil, by irrigating the soil or by drenching or spraying the soil with the aqueous solution. Significantly reduced amounts of metham are employed to reduce damage to the plant or vegetative material.
    Type: Grant
    Filed: December 10, 1990
    Date of Patent: December 24, 1991
    Inventor: William A. Haglund
  • Patent number: 5043008
    Abstract: A biocide composition comprises an effective amount of a biocide and an effective amount of a biocide activator selected from the group consisting of an alkyl phosphate, an alkenyl phosphate, a hydroxyalkyl phosphate, a polyoxyalkylene alkyl ether phosphate, a salt thereof, a polyoxyalkylene alkenyl ether phosphate, a salt thereof, a polyoxyalkylene hydroxyalkyl ether phosphate and a salt thereof.
    Type: Grant
    Filed: October 25, 1989
    Date of Patent: August 27, 1991
    Assignee: Kao Corporation
    Inventor: Tetsuji Iwasaki
  • Patent number: 5035878
    Abstract: Various types of biological treatments, including antineoplastic treatments with antineoplastic drugs, can result in damage to the blood-forming function of the bone marrow. This damage can be reversed, at least to some degree, with an effective amount (preferably an extremely low dose) of a pharmaceutically acceptable dithiocarbamic compound, including a compound of the formula R.sub.1 R.sub.2 NCSSM or R.sub.1 R.sub.2 NCSS-SCSNR.sup.3 R.sup.4, wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are the same or different aliphatic or cycloaliphatic or heterocycloaliphatic groups, unsubstituted or substituted by hydroxyl, or one of R.sup.1 and R.sup.2 and one of R.sup.3 and R.sup.4 can be H, or R.sup.1 and R.sup.2 or R.sup.3 and R.sup.
    Type: Grant
    Filed: October 10, 1989
    Date of Patent: July 30, 1991
    Assignee: University of Rochester
    Inventors: Richard F. Borch, Therese K. Schmalbach
  • Patent number: 5034412
    Abstract: Methods useful for inhibiting the release of interleukin-1 and for alleviating interleukin-1 mediated conditions, such as IL-1-mediated inflammation, comprising administration of an effective amount of a pharmaceutically acceptable antioxidant compound such as disulfiram, tetrakis [3-(2,6-di-tert-butyl-4-hydroxyphenyl)propionyloxy methyl]methane or 2,4-di-isobutyl-6-(N,N-dimethylaminomethyl)-phenol.
    Type: Grant
    Filed: December 19, 1990
    Date of Patent: July 23, 1991
    Assignee: Merrell Dow Pharmacueticals Inc.
    Inventors: George Ku, Niall Doherty
  • Patent number: 5007953
    Abstract: Methods of using comminuted Alder bark as a stimulator of seed germination and growth media comprising comminuted Alder bark are disclosed. Also disclosed are seed treatment dusts comprising an active ingredient, a diluent material and comminuted Alder bark and methods of using these dusts. The active ingredients include fungicides, insecticides and other pesticides. The diluent materials used include clays and talcs.
    Type: Grant
    Filed: December 22, 1988
    Date of Patent: April 16, 1991
    Assignee: Snake River Chemicals, Inc.
    Inventor: Charles C. Chollet
  • Patent number: 5006340
    Abstract: A crude drug ingredient having bactericidal activity incorporated into a curable composition comprising a (meth)acrylate type monomer, a polymerization initiator and if necessary a filler to formulate the ingredient into the drug having sustained release property. The curable composition containing the crude drug ingredient is applied to a defective part of a tooth or an artificial gum for preventing dental diseases such as carious tooth, pyorrhea alveolaris, and the like.
    Type: Grant
    Filed: February 12, 1990
    Date of Patent: April 9, 1991
    Assignee: Mitsui Petrochemical Industries, Ltd.
    Inventors: Mitsuru Atsuta, Takeshi Sakashita, Ryoichi Miyamoto, Yukinori Tanimura, Saburo Fuji
  • Patent number: 5001150
    Abstract: Non-dusty water-dispersible mancozeb granules (90%>100 micron diameter) are produced by a new process characterized by spray drying an aqueous slurry of .gtoreq.60% solids consisting of maneb or maneb dihydrate (5 microns, 50% 2-5 microns), a water soluble zinc salt and other formulation adjuvants.
    Type: Grant
    Filed: June 27, 1989
    Date of Patent: March 19, 1991
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Warren H. Yap
  • Patent number: 4994487
    Abstract: Crop yields in a plant bed are significantly enhanced by treating soil in the plant bed with a fungicidally effective amount of metham, the fungicidally effective amount being insufficient to retard growth of a plant. In the practice of the invention, the plant soil is treated with metham by dripping an aqueous solution of metham into a seed furrow, by injecting the aqueous solution into the soil or by drenching the soil with the aqueous solution, either at about the time of planting of the seed or vegetative material or by treatment of the soil surrounding established plant crops. Significantly reduced amounts of metham are employed to reduce damage to the planted seed or vegetative material.
    Type: Grant
    Filed: September 26, 1989
    Date of Patent: February 19, 1991
    Assignee: Washington State University Research Foundation
    Inventor: William A. Haglund
  • Patent number: 4975425
    Abstract: Foam compositions containing a herbicide or pesticide which are readily absorbed systemically by plant life are made by incorporating a gas such as air into a composition made up of an alcohol, a modified coconut acid or a blend of nonionic and anionic surfactants, water and a systemic herbicide or pesticide. These foam compositions are applied directly to plant life such as trees and are absorbed within three minutes, often within one minute.
    Type: Grant
    Filed: March 16, 1989
    Date of Patent: December 4, 1990
    Assignee: Mobay Corporation
    Inventor: Horace G. Barnett, Jr.
  • Patent number: 4938949
    Abstract: Various types of biological treatments, including antineoplastic treatments with antineoplastic drugs, can result in damage to the blood-forming function of the bone marrow. This damage can be reversed, at least to some degree, with an effective amount (preferably an extremely low dose) of a pharmaceutically acceptable dithiocarbamic compound, including a compound of the formula R.sub.1 R.sub.2 NCSSM or R.sub.1 R.sub.2 NCSS--SCSNR.sup.3 R.sup.4, wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are the same or different aliphatic or cycloaliphatic or heterocycloaliphatic groups, unsubstituted or substituted by hydroxyl, or one of R.sup.1 and R.sup.2 and one of R.sup.3 and R.sup.4 can be H, or R.sup.1 and R.sup.2 or R.sup.3 and R.sup.
    Type: Grant
    Filed: September 12, 1988
    Date of Patent: July 3, 1990
    Assignee: University of New York
    Inventors: Richard F. Borch, Therese K. Schmalbach
  • Patent number: 4935447
    Abstract: A method is disclosed for the containment and controlled release of and the substantial reduction of the leaching from the site of application of agricultural chemicals. In the disclosed method, the agricultural chemicals are applied to the soil dispersed in an aqueous gel-forming composition. Novel compositions of the agricultural chemicals dispersed in aqueous gel-forming compositions are also disclosed.
    Type: Grant
    Filed: January 13, 1988
    Date of Patent: June 19, 1990
    Assignee: Pfizer Inc.
    Inventors: Judson C. Philips, Hazen L. Hoyt, IV, Christopher A. Macri, Wesley L. Miller, John J. O'Neill
  • Patent number: 4935413
    Abstract: A physical property-improving reagent which comprises an alkenoylcarbamate compound of the formula: ##STR1## wherein R is a hydrogen atom or a lower alkyl group, X is an oxygen atom (--O--), a sulfur atom (--S--) or a substituted or unsubstituted imino group (--NR'--), R' being a hydrogen atom or a lower alkyl group, and Y is the residue of an active hydrogen atom-containing compound excluding --X-H therefrom dissolved in an organic solvent having a solubility parameter of not less than 8, which can impact excellent physical properties to a polymer produced with the same.
    Type: Grant
    Filed: June 5, 1987
    Date of Patent: June 19, 1990
    Assignee: Nippon Paint Co., Ltd.
    Inventors: Satoshi Urano, Ryuzo Mizuguchi, Noriyuki Tsuboniwa, Kei Aoki, Yuji Suzuki, Takeyasu Itoh
  • Patent number: 4908383
    Abstract: Novel N-phenyl-N-carboxythioureas of the formula I ##STR1## in which R.sub.1 and R.sub.2 each represents C.sub.1 -C.sub.10 alkyl, C.sub.3 -C.sub.7 cycloalkyl or C.sub.5 -C.sub.6 cycloalkenyl,R.sub.3 represents hydrogen, halogen, C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 alkoxy or C.sub.1 -C.sub.10 alkylthio,R.sub.4 represents C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl or phenyl-C.sub.1 -C.sub.7 alkyl; C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl or phenyl-C.sub.1 -C.sub.7 alkyl each mono- or poly-substituted by halogen or interrupted one or several times by oxygen and/or sulphur; C.sub.3 -C.sub.8 cycloalkyl; or C.sub.3 -C.sub.8 cycloalkyl mono- or poly-substituted by halogen or by C.sub.1 -C.sub.5 alkyl, andR.sub.5 represents C.sub.1 -C.sub.10 alkyl; phenyl-C.sub.1 -C.sub.7 alkyl; C.sub.1 -C.sub.10 alkyl or phenyl-C.sub.1 -C.sub.7 alkyl each mono- or poly-substituted by halogen or interrupted one or several times by oxygen and/or sulphur; C.
    Type: Grant
    Filed: May 23, 1989
    Date of Patent: March 13, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Jozef Drabek, Josef Ehrenfreund
  • Patent number: 4894393
    Abstract: The subject of the invention is the choline diethyl-dithiocarbamate having the following structural formula: ##STR1## as well as a process for its preparation from choline chloride and sodium diethyl-dithio-carbamate trihydrate.This substance is useful in the treatment of degenerative brain diseases.
    Type: Grant
    Filed: September 16, 1988
    Date of Patent: January 16, 1990
    Assignee: Lafon Pharma S.A.
    Inventors: Dat-Xuong Nguyen, Jean Rapin, Thadee Staron
  • Patent number: 4886825
    Abstract: The invention relates to plant protection compositions based on a two-component system of plant fungicides, one of which is 1-[2-(2,4-dichlorophenyl)pentyl]-1H-1,2,4-triazole and the other is Mancozeb, which is an [ethylenebis(dithiocarbamato)]manganese complex with [ethylene-bis(dithiocarbamato)]zinc of the formula II ##STR1## In the range from 1:3 to 1:100 the disclosed mixtures display enhanced fungicidal activities.
    Type: Grant
    Filed: July 5, 1988
    Date of Patent: December 12, 1989
    Assignee: Ciba-Geigy Corporation
    Inventors: Wilhelm Ruess, Pierre Urech, Jurg Eberle, Theodor Staub
  • Patent number: 4870101
    Abstract: Methods useful for inhibiting the release of interleukin-1 and for alleviating interleukin-1 mediated conditions, such as IL-1-mediated inflammation, comprising administration of an effective amount of a pharmaceutically acceptable antioxidant compound such as disulfiram, tetrakis [3-(2,6-di-tert-butyl-4-hydroxyphenyl)propionyloxy methyl]methane or 2,4-di-isobutyl-6-(N,N-dimethylaminomethyl)-phenol.
    Type: Grant
    Filed: February 18, 1988
    Date of Patent: September 26, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: George Ku, Niall Doherty
  • Patent number: 4829089
    Abstract: This disclosure describes certain substituted piperazine-1,4-naphthalenediones useful as anti-asthmatic agents.
    Type: Grant
    Filed: July 22, 1988
    Date of Patent: May 9, 1989
    Assignee: American Cyanamid Company
    Inventors: Jeffrey B. Medwid, Lawrence W. Torley, Andrew S. Tomcufcik
  • Patent number: 4824665
    Abstract: A method and a composition for attracting bark beetles, particularly southern pine beetles, and suppressing their further development to halt destructive forest infestations.
    Type: Grant
    Filed: March 31, 1987
    Date of Patent: April 25, 1989
    Inventor: Lary Roton
  • Patent number: 4824864
    Abstract: Zineb is stabilized by mixing it with calcium oxide in the absence of sulfur.
    Type: Grant
    Filed: July 11, 1985
    Date of Patent: April 25, 1989
    Assignee: BASF Aktiengesellschaft
    Inventors: Roman Fischer, Knut Koob, Friedrich Loecher
  • Patent number: 4820726
    Abstract: 4-Acylresorcinol esthers of the formula ##STR1## in which R.sub.1 is lower alkyl, R.sub.2 is fluorinated lower alkyl, R.sub.3 is hydrogen, lower alkoxy, trifluoromethyl or halogen, alk is an alkylene or hydroxyalkylene radical which is uninterrupted or interrupted by oxygen, one of the radicals R.sub.4, R.sub.5 and R.sub.7 is a group of the formula --NH--C(.dbd.O)--R.sub.8, a radical R.sub.4 or R.sub.5 which differs from this is a radical R.sub.9 and a radical R.sub.7 which differs from this is a radical R.sub.10, R.sub.6 is hydrogen, lower alkyl, trifluoromethyl, halogen, carboxyl which is free, esterified or amidated, cyano or lower alkanoyl, R.sub.8 is carboxyl which is free, esterified or amidated or 5-tetrazolyl, R.sub.9 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl and R.sub.10 is hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, cyano or carboxyl which is free, esterified or amidated, and their salts have antiallergic and antiinflammatory properties.
    Type: Grant
    Filed: January 14, 1987
    Date of Patent: April 11, 1989
    Assignee: Ciba-Geigy Corporation
    Inventors: Andreas Beck, Alfred Sallmann, Robert W. Lang, Paul Wenk
  • Patent number: 4789686
    Abstract: A concentrated aqueous solution of the sodium salt of methionine, which is practically free from inorganic salts, is produced from the medium resulting from the hydrolysis of 5-(.beta.-mercaptoethyl)hydantoin.
    Type: Grant
    Filed: July 14, 1987
    Date of Patent: December 6, 1988
    Assignee: AEC-Sociate de Chimie Organique et Biologique
    Inventor: Jean Giraud
  • Patent number: 4737518
    Abstract: Novel lipid derivatives of the formula ##STR1## [wherein R.sup.1 is alkyl or alkylcarbamoyl; R.sup.2 is hydrogen, hydroxy which may be substituted, amino which may be substituted or cyclic amino; R.sup.3 is a chemical binding or alkylene which may be substituted; R.sup.4 is hydrogen, alkyl or aralkyl; X and Y are independently O, S or an imino group which may be substituted, and when Y is an imino group, Y, together with the imino group represented by X or R.sup.4, may form a ring; and Z is imino or a nitrogen-containing heterocyclic ring which may be substituted] and salts thereof have inhibiting activity on platelet activating factor and are useful as a preventive or therapeutic agent for a variety of circulatory diseases and allergic disorders and also as an antineoplastic agent.
    Type: Grant
    Filed: September 12, 1986
    Date of Patent: April 12, 1988
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Hiroaki Nomura, Kohei Nishikawa, Susumu Tsushima, Yoshio Kozai
  • Patent number: 4725598
    Abstract: Disclosed herein are a derivative of dihydroxybenzamide represented by the formula(I): ##STR1## wherein (1) R.sup.1 represents a hydrogen atom or a lower alkyl group and R.sup.2 represents a straight chain-alkyl group of 4 to 12 carbon atoms, a branched chain-alkyl group of 4 to 12 carbon atoms, a cyclo-alkyl group of 4 to 12 carbon atoms, ##STR2## wherein n is an integer of 1 to 6, or a pyridyl group which is substituted or unsubstituted, or (2) R.sup.1 and R.sup.2 are cyclized to make a heterocycle containing amino group represented by the formula ##STR3## wherein X represents a nitrogen atom or a methine and Y represents a hydrogen atom, an alkyl group of 1 to 6 carbon atoms or a phenyl group, and a pharmaceutical composition containing the same.
    Type: Grant
    Filed: December 8, 1986
    Date of Patent: February 16, 1988
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Hitoshi Takita, Sakuo Noda, Yutaka Mukaida, Kazuyoshi Inada, Mari Toji, Fumihiko Kimura, Toyohiko Nitta, Kohju Watanabe, Kiyonori Umekawa, Kobayashi, Hidetoshi
  • Patent number: 4645661
    Abstract: A method for alleviating cisplatin compound-induced nephrotoxicity in animals comprising administering to the animal an effective amount of a polar dithiocarbamate compound. The polar dithiocarbamate compounds have the formula: ##STR1## In the above formula, R.sup.1 and R.sup.2 are hydrocarbon groups and R.sup.1, R.sup.2, or both R.sup.1 and R.sup.2 contain a polar group substituted thereon. M is a pharmaceutically acceptable cation and n is an integer of from 1 to 3.Novel polar dithiocarbamate compounds are disclosed as well.
    Type: Grant
    Filed: June 29, 1984
    Date of Patent: February 24, 1987
    Assignee: St. Jude Children's Research Hospital
    Inventor: Gregory R. Schonbaum
  • Patent number: 4608385
    Abstract: Use of an N-phenylcarbamate of the formula: ##STR1## as a fungicidal agent against phytopathogenic fungi, particularly their strains resistant to benzimidazole thiophanate fungicides and/or cyclic imide fungicides.
    Type: Grant
    Filed: October 22, 1982
    Date of Patent: August 26, 1986
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Hiroshi Noguchi, Toshiro Kato, Junya Takahashi, Yukio Ishiguri, Shigeo Yamamoto, Katsuzo Kamoshita
  • Patent number: 4594238
    Abstract: Dithiocarbamic compounds, administered about 0.5 to about 6 hours after Pt compounds, have been found to counter the toxicity of the platinum in multicellular organisms (e.g. mammals). For example, neoplastic growths in mammals can be treated with cis-diamine or cis-diammine Pt(II) complexes with greatly lessened risk of nephrotoxicity, bone marrow toxicity, or damage to the digestive system of the mammal, provided the dithiocarbamic compound is timely (and preferably parenterally) administered. Particularly effective dithiocarbamic compounds are monomeric (e.g. ##STR1## where M is a pharmaceutically acceptable cation and R.sup.1 and R.sup.2 are lower aliphatic (or cycloaliphatic or heterocycloaliphatic groups) or, less preferably, dimeric, e.g. ##STR2## wherein R.sup.1 and R.sup.2 are as defined previously, and R.sup.3 and R.sup.4 are defined in the same manner as R.sup.1 and R.sup.2.
    Type: Grant
    Filed: January 5, 1984
    Date of Patent: June 10, 1986
    Assignee: Regents of University of Minnesota
    Inventor: Richard F. Borch
  • Patent number: 4581224
    Abstract: Dithiocarbamic compounds, administered about 0.5 to about 6 hours after Pt compounds, have been found to counter the toxicity of the platinum in multi-cellular organisms (e.g. mammals). For example, neoplastic growths in mammals can be treated with cis-diamine or cis-diamine Pt(II) complexes with greatly lessened risk of nephrotoxicity, bone marrow toxicity, or damage to the digestive system of the mammal, provided the dithiocarbamic compound is timely (and preferably parenterally) administered. Particularly effective dithiocarbamic compounds are monomeric (e.g. ##STR1## where M is a pharmaceutically acceptable cation and R.sup.1 and R.sup.2 are lower aliphatic (or cycloaliphatic or heterocycloaliphatic groups) or, less preferably, dimeric, e.g. ##STR2## wherein R.sup.1 and R.sup.2 are as defined previously, and R.sup.3 and R.sup.4 are defined in the same manner as R.sup.1 and R.sup.2.
    Type: Grant
    Filed: January 5, 1984
    Date of Patent: April 8, 1986
    Assignee: Regents of the University of Minnesota
    Inventor: Richard F. Borch
  • Patent number: H811
    Abstract: A biocidal composition containing, as active ingredients, at least one imidazole compound represented by formula (I): ##STR1## wherein R.sup.1 represents a phenyl group, a halogen-substituted phenyl group, an alkyl group, or a halogen-substituted alkyl group; and R.sup.2 represents a halogen atom, and at least one other specific compound. The combination of the compound represented by formula (I) and other specific compound can produce an unexpected effect in amount required and biocidal spectrum.
    Type: Grant
    Filed: March 13, 1989
    Date of Patent: August 7, 1990
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventors: Rikuo Nasu, Terumasa Komyoji, Toshio Nakajima, Kazumi Suzuki, Keiichiro Ito, Tekeshi Ohshima, Hideshi Yoshimura