Abstract: This invention relates to a method for the prophylaxis of or for treating COPD by administering a PDE4 inhibitor which has a defined therapeutic ratio.

Abstract: Hydroxyeicosatetraenoic acid esters and methods of their use in treating dry eye disorders are disclosed.

Abstract: Disclosed herein is an aqueous suspension of insecticidally active compounds comprising a solid active compound applied as a coating to an inorganic carrier and auxiliaries, water and glycerol.

Abstract: A solvent system for pyrethroids and pyrethrins comprises a terpene or a terpene derivative such as a terpene alcohol, aldehyde or ketone. In a preferred embodiment, the solvent system further comprises an alkylene glycol ether. Compositions comprising pyrethroids and/or pyrethrins in such a solvent system do not crystallize at cold temperatures and have increased efficacy compared to formulations containing conventional solvents.

Abstract: The present invention provides a low-irritant pesticidal emulsifiable concentrate comprising (a) 1 to 60% by weight of at least one pesticidal active ingredient compound selected from the group consisting of pyriproxyfen and a pyrethroid compound, (b) 2 to 15% by weight of at least one surfactant and (c) 15 to 90% by weight of at least one aromatic ester solvent represented by the formula: Ar—X—COOR  [1] or the formula: RCOO—X—Ar  [2] [wherein R represents non-aromatic group having 1 to 6 carbon atoms; Ar represents an aromatic group; and X represents a single bond or an alkylene group having 1 to 6 carbon atoms]. The pesticidal emulsifiable concentrate of the present invention can be used as an emulsion which is superior in emulsion stability when using after diluting with water, and has low irritation.

Abstract: The invention provides novel compounds of the Formula (I) that stimulate rates of glucose oxidation in myocardial cells.

Abstract: Process of treatment of mammals, including humans to treat diseases or conditions of the type which are normally treated with retinoid-like compounds is disclosed, with pharmaceutical compositions containing an active compound which is a selective agonist of the RXR retinoid receptor sites in preference to the RAR retinoid receptor sites. A compound is defined to be a selective agonist of the RXR receptor site if the compound is at least approximately ten times more effective as an agonist in the RXR receptor sites than in the RAR receptor sites.

Abstract: The invention concerns the use of certain compounds related to fatty acids to control nematodes that infest plants or the situs of plants. Nematodes that parasitize animals can also be controlled using the methods and composition of this invention. Certain of the useful compounds are fatty acid esters that are predicted inhibitors of nematode delta-12 fatty acid desaturases and can be, for example, from C16 to C20 in length.

Abstract: The invention concerns the use of certain compounds related to fatty acids to control nematodes that infest plants or the situs of plants. Nematodes parasitizing animals can also be controlled using the methods and composition of this invention. The useful compounds are inhibitors of nematode delta-12 fatty acid desaturases and can be, for example, from C16 to C20 in length. A feature of these compounds is that their inhibitory effect on the activity of a nematode delta-12 desaturase, or on the viability or fecundity of a nematode, is smaller in the presence of the product of a delta-12 fatty acid desaturase (e.g., linoleate) than in the presence of the substrate of the enzyme (e.g., oleate).

Abstract: The present invention provides functionalized cyclopropane compounds that have pesticidal and/or TMOF activity. The pesticidal compounds and other compounds of the present invention are usefully employed in the control of pests, particularly insect pests such as mosquitoes, which ingest blood.

Abstract: The present invention concerns the use of antimuscarinic agents for the treatment of urinary disorders. The invention provides a method of treating urinary disorder in a mammal, including man, comprising administering to said mammal, in need of such a treatment, a therapeutically effective amount of an antimuscarinic agent, or solvate or prodrug thereof, said administration being performed by inhalation or insufflation.

Abstract: The present invention relates to a method of controlling insect infestation whereby an insecticidal coating having an extended residual period of a few months to a year is applied to a surface. A removable cover may be positioned near the surface to create a substantially darkened region to exploit some insects' natural tendencies to hide in dark places during daylight hours. Alternatively, the insecticide may be applied prior to the hatching of the insect eggs to control the population upon hatching. The method is especially effective for controlling the presence of gypsy moth caterpillars on trees. The present method may be accomplished by covering a portion of a tree trunk with an insecticidal coating containing an active ingredient such as chlorpyrifos, pyrethroid, permethrin, or tralomethrin and covering the coated area with burlap. In addition, the method of the present invention can be used to control the presence of insects on the sides of houses or other structures.

Abstract: A wood treatment material having a synergistic combination of insecticides including boron-containing compounds and synthetic pyrethroids, is provided. This combination is shown to be especially effective in providing resistance to insect attack when wood is treated with this combination. Resistance to attack by Formosan termites, in particular, is provided, in a cost-effective manner. Also provided is wood treated by this combination, and a method of treatment for composite wood.

Abstract: An insect control article to control flying insects. The insect control article has a substrate that is impregnated with an active insect control ingredient that is available for passive evaporation. The active insect control ingredient is selected from the group consisting of transfluthrin, prallethrin, tefluthrin, esbiothrin, and combinations thereof. The method of the invention for controlling flying insects includes providing an insect control article having a substrate that is impregnated with an active insect control ingredient available for passive evaporation, wherein the active insect control ingredient is selected from the group consisting of transfluthrin, prallethrin, vaporthrin, teflurthrin, esbiothrin, DDVP, and combinations thereof.

Abstract: Controlled release devices are shaped and placed in locations through which insects and/or other cold blooded animals generally enter an area or a structure sought to be protected. The controlled release devices include a polymeric matrix and a pesticide contained in the matrix. The pesticide is gradually released out of the matrix to the surface of the device. The pesticide on the surface of the device kills the intruding insects or other cold blooded animals that come in contact with the pesticide. In addition, if the device is in contact with a permeable structure or object, the pesticide released onto the surface of the device is absorbed by such permeable structure or object to provide a barrier to entry by the insects and/or other cold blooded animals.

Abstract: A method of protecting a corn plant from destructive insects which comprises applying to the seed from which it grows or the soil from which the seed grows a composition comprising an insecticidal 1-arylpyrazole and an insect repellent. A composition comprising the insecticidal 1-arylpyrazole and the repellent.

Abstract: Solid water-dispersible compositions containing microencapsulated pesticides are produced by spray-drying an aqueous suspension of said pesticides in the presence of a water-soluble polymer.

Abstract: Remedies or preventives for diseases with a need for immunoregulation, diseases with a need for inhibition of inflammation, diseases with a need for regulation of tumor necrosis factor production, diseases with a need for regulation of fungal growth, diseases with a need for regulation of cell adhesion or disease with a deed for induction of heat-shock protein, which contain as the active ingredient at least one compound selected from among cyclopentenone derivatives represented by general formula [I], optically active isomers and salts thereof, wherein R1 and R2 are the same or different and each represents hydrogen, an aliphatic group, an aromatic group or an aromatic aliphatic group.

Abstract: New tropane analogs that bind to monoamine transporters are described, particularly, 8-aza, 8carbo and 8-oxo tropanes having 6- or 7- substituents. The compounds of the present invention can be racemic, pure R-enantiomers, or pure S-enantiomers Certain preferred compounds of the present invention have a high selectivity for the DAT versus the SERT. Also described are pharmaceutical therapeutic compositions comprising the compounds formulated in a pharmaceutically acceptable carrier and a method for inhibiting 5-hydroxy-tryptamine reuptake of a monoamine transporter by contacting the monoamine transporter with a 5-hydroxytryptamine reuptake inhibiting amount of a compound of the present invention. Preferred monoamine transporters for the practice of the present invention include the dopamine transporter, the serotonin transporter and the norepinephrine transporter.

Abstract: Microcapsules formed from an aminoplast shell wall and an encapsulated ingredient or ingredients enclosed within the wall in which the wall contains a base-cleavable ester moiety. These capsules have been found to be sensitive to the presence of base such that in the presence of base, the capsule walls are relatively quickly disintegrated or degraded so as to produce a relatively quick release of the encapsulated materials. Microcapsules of this invention are particularly suitable for use in controlling insects having an alkaline gut such as certain lepidoptera in that the capsule shell wall may be designed so as to quickly disintegrate under the alkaline conditions present in the gut of the insect thus providing a microcapsule which is safe to handle but which is selectively effective against certain undesirable insects while not harmful to beneficial insects or insects which do not feed on the capsule materials.

Abstract: Clear, high load water miscible emulsions of pyrethroid insecticides or triazole fungicides, as a single phase, translocatable composition which is free of xylene and alkylphenol ethoxylate surfactants and concentrate matrix for the active agricultural component at between about 5 and about 25 wt. % active concentration.

Abstract: Clear, high load water miscible emulsions of pyrethroid insecticides or triazole fungicides, as a single phase, translocatable composition which is free of xylene and alkylphenol ethoxylate surfactants and concentrate matrix for the active agricultural component at between about 5 and about 25 wt. % active concentration.

Abstract: Compounds represented by the general formula (1):   (where R1 is SR6 or NR7R8, where R6 is typically an alkyl group having 1-6 carbon atoms, R7 is a hydrogen atom, an alkyl group having 1-6 carbon atoms or a nitro group, and R8 is a hydrogen atom or an alkyl group having 1-6 carbon atoms; R2 and R3 are each typically a hydrogen atom or an alkyl group having 1-6 carbon atoms; R4 is a hydrogen atom, an alkyl group having 1-6 carbon atoms or an amidino group of which the amine portion may be substituted by an alkyl or nitro group; R5 is a hydrogen atom or an alkyl group having 1-6 carbon atoms; Y1, Y2, Y3 and Y4 which may be the same or different are each typically a hydrogen atom, a halogen atom or an alkoxy group having 1-6 carbon atoms; n and m are each an integer of 0 or 1), or possible stereoisomers or optically active forms of the compounds or pharmaceutically acceptable salts thereof.

Abstract: An insect control article to control flying insects. The insect control article has a non-absorptive and inert substrate that is coated with an active insect control ingredient that is available for passive evaporation. The active insect control ingredient is selected from the group consisting of transfluthrin, tefluthrin, and combinations thereof. The method of the invention for controlling flying insects includes providing an insect control article having a non-absorptive, inert substrate that is coated with an active insect control ingredient available for passive evaporation, wherein the active insect control ingredient is selected from the group consisting of transfluthrin, tefluthrin, and combinations thereof. The insect control article is then placed in an environment in such a manner that the substrate of the insect control article is exposed to non-augmented air movement, and the active insect control ingredient coated on the substrate is allowed to evaporate passively into the air.

Abstract: The present invention provides synthetic methods and compositions for treatment of autoimmune and anti-inflammatory disorders comprising administering an effective amount of a derivative of triptolide alone or in combination or alternation with other anti-autoimmune or anti-inflammatory compounds.

Abstract: An insecticidal and miticidal composition comprising as active ingredients 4-bromo-2-(4-chloro-phenyl)-1-(ethoxymethyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile and a pyrethroid insecticidal ingredient(s). This insecticidal and miticidal composition is effective against pests and mites which are resistant against the insecticidal and miticidal agents on the market.

Abstract: A stable medicated animal care formulation including, by weight; (a) 0.1-10% of an active agricultural ingredient, of an animal care and/or veterinary reagents, (b) 0.0002-40% of a microemulsion concentrate including: (i) 0-10% of a castor oil ethoxylate or tristyryl phenol ethoxylate, (ii) 0-1% of an ethoxylated phosphoric acid as pH buffer, (iii) 0.0002-4% of a N—C8-C18 alkyl pyrrolidone and (iv) 0-6% of a N—C1-C4 alkyl pyrrolidone, (c) a surfactant with shampoo properties, and (d) water, wherein (c)+(d) is 50-99.4%.

Abstract: Compounds of formula (I) in which R represents the remainder of an alcohol used in the pyrethroid series, in all their possible stereoisomer forms as well as their mixtures, and compositions comprising them. The compounds of formula (I) are useful as pesticides.

Abstract: Compounds of formula (I) in which R1 is halo-C1-10 alkyl; halo-C2-10 alkenyl; or (CH2)nY in which n is 1 or 2 and Y is OH, CN, N3, OR3, SH, S(O)pR4, S(O)3H, NH2, NHR5, NR6R7, NHCOR8, NO2, CO2H, CONHR9, 1H-tetrazol-5-yl, 5-phenyltetrazol-2-yl or PO3H2; R3, R5, R6, R7, R8 and R9 are each selected independently from C1-4 alkyl, aryl and aryl-C1-4 alkyl; R4 is selected from C1-4 alkyl, aryl, aryl-C1-4 alkyl, and 1H-tetrazol-5-yl, carboxy-(1-4C)alkyl and 1H-tetrazol-5-yl-C1-4 alkyl; and p is 0, 1, 2 or 3; or a salt or ester thereof, provided that R1 is not methoxymethyl, modulate metabotropic glutamate receptor function and are useful in treating disorders of the central nervous system.

Abstract: A mixture for application on an animal to provide protection against insects, parasites, arachnids and/or other anthropods, and ectoparasites and endoparasites in general, viruses, bacteria and/or other microorganisms is provided. The mixture includes a carrier, especially mineral oil, having a viscosity of from 150 to 600, and especially 225 to 450, centistokes. The mixture also includes an insecticide, ectoparasitide, endoparasitide, viricide and/or bacteriacide that is blended with the carrier.

Abstract: The present invention relates to novel amidino compounds of formula (I), or a salt, solvate, or physiologically functional derivative thereof; wherein R1 is selected from C1-4 alkyl, C3-4 cycloalkyl, C1-4 hydroxyalkyl, and C1-4 haloalkyl; to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use as selective inhibitors of inducible nitric oxide synthase.

Abstract: The present invention relates to novel insecticidal gel formulations for the controlled and sustained release of insecticidally active compounds by means of a heat source.

Abstract: A method of preventing damage to the seed and/or shoots and foliage of a plant by a pest includes treating the seed from which the plant grows with a composition that includes a combination of at least one pyrethrin or synthetic pyrethroid and at least one other insecticide selected from the group consisting of an oxadiazine derivative, a chloronicotinyl, a nitroguanidine, a pyrrol, a pyrazone, a diacylhydrazine, a triazole, a biological/fermentation product, a phenyl pyrazole, an organophosphate and a carbamate. It is preferred that when the other insecticide is an oxadiazine derivative, the pyrethroid is selected from the group consisting of taufluvalinate, flumethrin, trans-cyfluthrin, kadethrin, bioresmethrin, tetramethrin, phenothrin, empenthrin, cyphenothrin, prallethrin, imiprothrin, allethrin and bioallethrin. The treatment is applied to the unsown seed.

Abstract: The present provides methods and compositions that enable effective delivery of nucleic acids to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions enable effective gene transfer and subsequent expression to a majority of cells throughout a solid organ such as the heart. Methods and compositions of the invention preferably provide enhanced vascular permeability that enables increased gene transfer to targeted cells, but without significant degradation or injury to endothelial cell layers. Global delivery of nucleic acid to an intact heart has been achieved with as little as 2 minutes of intracoronary exposure to the administered nucleic acid.

Abstract: A composition for control of parasitic insects and acarids, comprising a combination of pyrethroids and chloronicotinyl compounds.

Abstract: An aqueous suspension formulation of encapsulated pesticide comprising 3 to 30% by weight of nonionic water-soluble substance which is a solid at room temperature and has 50 to 700 of molecular weight is easy to handle, excellent in preservative stability and highly antiseptic.

Abstract: This invention relates to compounds of the formula: 1

Abstract: Disclosed as endothelin converting enzyme inhibitors are the compounds of the formula wherein the variables have the meanings as defined hereinbefore.

Abstract: (S)-2-methyl-4-oxo-3-(2-propynyl)-cyclopent-2-enyl (1R)-trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate represented by the formula: is a compound excellent in controlling effect on insect pests and harmlessness to mammals.

Abstract: An insect coil having an extended, burnable body. The body has multiple treated zones bearing a volatilizable insect control active ingredient at insect controlling levels separated by spacing zones bearing a level of insect control active ingredient lesser than that of the treated zones. When burned, the insect coil releases bursts spaced in time of the active ingredient in insect controlling quantities. Preferably the spacing zones are active ingredient free, and the first treated zone to be burned has an active ingredient level higher than the remaining treated zones. A method of controlling insects by use of the insect coil also is disclosed.

Abstract: Solid water-dispersible compositions containing microencapsulated pesticides are produced by spray-drying an aqueous suspension of said pesticides in the presence of a water-soluble polymer, preferably polyvinyl alcohol.

Abstract: The invention relates to novel compounds of the formula in which R1 is C1-4alkyl and (Y—X) is CH2, C1-2alkylthio-CH═ or C1-2alkyl-ON═ and Z is an aldimino or ketimino group, and to their preparation, as well as fungicidal compositions with such compounds as active substances. The compounds can be employed for controlling fungi in agriculture, in horticulture and in wood preservation.

Abstract: Compounds having the formulas below, where R is H, lower alkyl, or a pharmaceutically acceptable salt, and where R1 represents i-propyl, t-butyl or n-butyl groups, have selective RXR retionoid agonist activity.

Abstract: New pesticidal compositions which comprise at least one signal substance, at least one UV absorber which is only sparingly miscible with water, at least one unsaturated oil which is only sparingly miscible with water and, if desired, pesticidally active compounds and/or additives, a process for the preparation of the new compositions, and their use for controlling insects and undesirable representatives of the order Acarina.

Abstract: To present printed wiring boards and other electronic components having excellent cockroach repelling performance even after solder reflow or solder flow. A conductive layer having a mounting land is provided on a insulating layer as a substrate, a solder resist is applied to cover the conductive layer excluding the mounting land, and an electronic component material containing a cockroach repellent is applied on the solder resist. This electronic component material is a paste containing a resin curable by crosslinking, a cockroach repellent, and a filler such as silica or talc, and by crosslinking and curing the resin by chemical reaction, a dried cockroach repelling layer is exposed and formed on the surface of the printed wiring board.

Abstract: Certain six-membered aromatic and heteroaromatic-dioxobutyric acid derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

Abstract: Alkoxy and/or acyloxy disubstituted and polysubstituted aralkyl and aralkenyl bis-quaternary ammonium derivatives of cyclic alkanol diesters have neuromuscular relaxant properties.

Abstract: The present invention provides a device, preferably a collar or ear tag, capable of the controlled, sustained release of an effective amount of an active ingredient that can protect an animal against arthropod pests, comprising a reservoir containing a novel gel formulation comprising a fatty acid, an organic solvent which is a linear aliphatic ester, a silicone-based fluid, or a combination thereof, and an active ingredient that can protect the animal against one or more arthropod pests.

Abstract: The present invention provides a device, preferably a collar or ear tag, capable of the controlled, sustained release of an effective amount of an active ingredient that can protect an animal against arthropod pests, comprising a reservoir containing a novel gel formulation comprising a fatty acid, an organic solvent which is a linear aliphatic ester, a silicone-based fluid, or a combination thereof, and an active ingredient that can protect the animal against one or more arthropod pests.

Abstract: A method for treating COPD is disclosed comprising administering compounds of Formula (I) wherein the terms R1, R3, X, X2 and Z are herein defined.