Abstract: Methods for preventing and treating corneal haze resulting from exposure of the eye to laser irradiation are disclosed. The methods include administration of compositions of wound healing modulators to the eye. Compositions for use in preventing and treating the corneal haze are also disclosed.

Abstract: Oligomeric thiocarbonates such as hexathiodicarbonate salts and thioesters are used as pesticides and preservatives. Certain oligomeric thiocarbonate salts, notably quaternary ammonium hexathiodicarbonates, are prepared. The compounds are stabilized with added base and/or sulfide.

Abstract: Novel compounds of formula I ##STR1## wherein R is selected from butyl, diethoxymethyl, cyclohexylmethyl, cyclohex-3-enylmethyl, benzyl, 4-chlorobenzyl, 4-methylbenzyl and 4-methoxybenzyl, R.sub.1 is selected from hydrogen and hydroxy, R.sub.2 is selected from hydrogen, chlorobenzyl, dichlorobenzyl, .alpha.-cyclopropyl-dichloro-benzyl, dichlorophenyl-2-hydroxy-ethyl, dimethylbenzyl, trimethoxybenzyl, methylenedioxybenzyl, chlorophenylethyl, dichlorophenylethyl, chloro-iodo-phenylethyl, dimethoxyphenylethyl, methylenedioxyphenylethyl, trimethoxyphenylethyl, 3-phenylprop-2-yl, 3-phenyl-3-hydroxy-prop-2-yl, dichlorophenylpropyl, dichlorophenyl-3-hydroxyprop-2-yl, dichlorophenylbutyl and quinolin-4-ylmethyl, and R.sub.3 is selected from hydrogen and methyl, and salts thereof, have GABA.sub.B -antagonistic properties and can be used for the treatment of diseases responsive to GABA.sub.B -antagonists.

Abstract: A method has been discovered for the control of arthropod pests which comprises treating the pest with an effective amount of selected fluorocarbons.

Abstract: Methods for treating the cornea following UV laser irradiation and resulting photoablation of corneal tissue are disclosed. The methods include administration of compositions of a non-steroidal antiinflammatory to the eye. Compositions for use in treating the cornea are also disclosed.

Abstract: A method of inhibiting growth, transformation and/or metastasis of mammalian cells, particularly epithelial cells, in which activity of at least one enzyme, which participates in purine metabolism or regulation of nucleotide levels or the relative ratios of their phosphorylated states, is elevated. In particular, a method of inhibiting transformation, growth and/or metastasis of mammalian cells in which a DNA tumor virus, a DNA tumor virus factor or other factor which has an equivalent effect on cells has acted.

Abstract: The present invention relates to the use of analogs of creatine, such as cyclocreatine, as antiviral agents. Analogs of creatine can be used as antiviral agents against a variety of viruses, particularly DNA viruses, such as Herpes viruses (e.g., HSV-1, HSV-2, cytomegaloviruses, Varicella-Zoster virus) and adenovirus. The invention further relates to creatine analogs including four classes of creatine analogs selected as candidate antiviral compounds: (1) creatine analogs that can be phosphorylated by creatine kinase but differ in their phosphoryl group transfer potential, (2) bisubstrate inhibitors of creatine kinase comprising covalently linked structural analogs of adenosine triphosphate (ATP) and creatine, (3) creatine analogs which can act as irreversible inhibitors of creatine kinase, and (4) N-phosphorocreatine analogs bearing non-transferable moieties which mimic the N-phosphoryl group.

Abstract: Oligomeric thiocarbonates such as hexathiodicarbonate salts and thioesters are used as pesticides and preservatives. Certain oligomeric thiocarbonate salts, notably quaternary ammonium hexathiodicarbonates, are prepared. The compounds are stabilized with added base and/or sulfide.

Abstract: The composition, methods of synthesis, and applications of a new class of tumor selective antineoplastic drugs is described. These novel antineoplastic agents are of the general structure: A-C-B. The agents are designed with two key functionalities: a trigger which toxifies the drug; (A) and a deactivator which detoxifies the drug (B) The trigger is selected such that it is activated by an enzyme which is present in elevated levels in the tumor. The deactivator is selected such that it is actuated by an enzyme ubiquitous to all tissues. The fate of the drug in a given cell is then determined by the ratio of the enzymatic activity that triggers toxication to the enzymatic activity which detoxifies the drug. The partitioning of the drug between toxic metabolite and nontoxic metabolite defines the resulting specificity of cytotoxic effect.

Abstract: Zwitterionic compounds selected from:taurine (2-aminoethanesulphonic acid),2(N-morpholino)ethanesulphonic acid (MES),N-(2-acetamido)iminodiacetic acid (ADA),piperazine-N,N'bis(2-ethanesulphonic acid (PIPES),N-(2-acetamido)-2-aminoethanesulphonic acid (ACES),N,N-bis(2-hydroxyethyl)-2-aminoethanesulphonic acid (BES),3-(N-morpholino)propanesulphonic (MOPS),N-N[tris(hydroxymethyl)-methyl]-2-aminoethanesulphonic acid (TES),N-2-hydroxyethylpiperazine-N'-2-ethanesulphonic acid (HEPES),N-2-hydroxyethylpiperazine-N'3-propanesulphonic acid (H)EPPS),2-(cyclohexylamino)ethanesulphonic acid (CHES) or 3-(cyclohexylamino)propanesulphonic acid (CAPS),and their N-halo derivatives can be used separately or in combination in the treatment of related clinical conditions by stimulating myeloperoxidase activity, which in turn stimulates hypochlorous acid production in vivo, which leads inter alia to enhanced leukotriene inactivation.

Abstract: An adsorbent for a serum amyloid protein, which includes a water-insoluble carrier and either a compound selected from a compound having an anionic functional group, a polyanionic compound having more than one anionic functional groups, aniline and an aniline derivative, the compound being immobilized onto the carrier, or a group of the formula: --NR.sup.1 R.sup.2, wherein R.sup.1 is hydrogen atom, methyl group or ethyl group, and R.sup.2 is an atomic group satisfying that the value of log P, in which P is a distribution coefficient in a water-octanol system, of a compound of the formula: R.sup.2 H is from 0 to 3.2, the group being bonded to the carrier, and a method for removing a serum amyloid protein from body fluid through a removing apparatus using the above adsorbent. According to the present invention, SA proteins, particularly SAA proteins and SAP proteins can be selectively removed from body fluid without decreasing HDL largely. Besides, the adsorbent can be provided at a low cost.

Abstract: An effective delayed-action insecticide for use against the imported fire ant (IFA), as well as against infestations of other insects. The insecticide consists of an oil insoluble surfactant, preferably an anionic fluorochemical surfactant, as the active ingredient. The insecticide further consists of a carrier, which is a source of food for the IFA or other insect. This carrier is impregnated with the anionic fluorosurfactant to provide a toxic bait. In a preferred embodiment, the insecticide contains 0.3 to 0.5% by weight anionic fluorosurfactant; and a member selected from the group comprising dried yellow corn meal, corn grit, crushed wheat, and cracked wheat in a concentration of 94.7 to 94.5% by weight, as the carrier. Soybean oil, in a concentration of 5.0% by weight, is preferably applied as an attractant. A method for formulating the insecticide by dissolving the anionic fluorosurfactant in a solvent, such as acetone or methanol, and mixing the resulting solution with the carrier, is also disclosed.

Abstract: A method has been discovered for the control of arthropod pests which comprises treating the pest with an effective amount of selected fluorocarbons.

Abstract: A method of inhibiting cell infection by herpes simplex virus-1 or -2. The method includes contacting the virus with a macrocyclic chromotropic acid compound, in an amount effective to inhibit cell infectivity of the virus.

Abstract: Formulations or products are caused to be active antimicrobials by the addition thereto of at least one effective amount of at least one crystalline mixed metal hydroxide (MMOH) conforming substantially to the formulaLi.sub.m D.sub.d T(OH) (m+2d+3+na) (A.sup.n).sub.a.xH.sub.2 Owhere m is zero to one, D is a divalent metal, d is from zero to 4, T is a trivalent metal, A represents at least one anion or negative-valence radical, (m+2d+3+na) is equal or to greater than 3, (m+d) is greater than zero, and xH.sub.2 O represents excess waters of hydration. The MMOH forms an adduct with, an coats, the microbes, thereby deactivating the microbes.

Abstract: Tricyclic hydroxyurea and hydroxamate compounds, pharmaceutical compositions, and their use as as inhibitors of the oxidation of polyunsaturated fatty acids, such as by inhibition on the 5-lipoxygenase enzyme, and treatment of diseases therein.

Abstract: A series of 2-amino-5,6-dimethyl-1,4-benzoquinone derivatives, inhibitors of cyclooxygenase and lipoxygenase and useful as antiallergic and antiinflammatory agents.

Abstract: A pharmaceutical composition for the treatment of a liver disorder, comprising as an effective agent against liver dysfunction, a mixture in effective amounts of the components:(a) L-Asparaginic acid;(b) L-Cysteine;(c) L-Glutaminic acid;(d) sodium selenate; and(e) zinc acetate or zinc sulfate in the following proportions: 0.020 to 2.00:0.025 to 1.00: 0.025 to 5.00:28.10.sup.-6 to 500.10.sup.-6 :0.010 to 0.300 by weight.

Abstract: The present invention relates to a method of treating or preventing a microbial infection, such as Pneumocystis carinii or Toxoplasma gondii, in a patient comprising administering to the patient an antimicrobially effective amount of p-acetamidobenzoic acid or a pharmaceutically acceptable salt thereof so that the microbial infection is inhibited. P-acetamidobenzoic acid or an acceptable salt thereof can be used to treat infections caused by Pneumocystis carinii, Toxoplasma gondii, Plasmodium species and other microorganisms containing the enzyme dihydropteroate synthetase such as most bacteria and some yeasts. The method of the present invention is particularly applicable in situations where the patient is immunosuppressed.

Abstract: The reproductive cycle of insects is affected by applying a solution or suspension of a material having the formula:NX.sub.2 (CX.sub.2).sub.m SO.sub.3 Z,where each X is selected from the group consisting of H, OH, C.sub.n H.sub.2n+1, C.sub.n H.sub.2n, Cl, Br, and I; Z is selected from the group consisting of H, K, and Na, and n and m are integral numbers of from 2 to 10. Preferably, the compound applied for control of the insect reproductive cycle is taurine. The material may also be mixed with fruits. The concentration of the material should be at least 0.04M.

Abstract: Pharmaceutically active combination comprising an ionic vanadium compound and thiosulphate or sulfite compound and optionally selenium, pharmaceutical compositions containing same and method for treating malignant tumors, arteriosclerosis and mental syndromes in the elderly.

Abstract: A virucidal agent having broad-spectrum activity contains at least 70% by weight of ethanol and/or propanols and from 0.5 to 5% by weight of a short-chain organic acid.

Abstract: A solution of DMSO and a body reactive agent (such as citric acid) is provided, and is typically topically applied to the body.

Abstract: A compound selected from the group consisting of all possible isomeric forms and mixtures thereof of a compound of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, alkenyl and alkynyl of 2 to 8 carbon atoms and cycloalkyl and cycloalkylalkyl of 3 to 8 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, alkenyl and alkynyl of 2 to 8 carbon atoms, cycloalkyl of 3 to 8 carbon atoms and acyl of 1 to 9 carbon atoms, X.sub.1 and X.sub.2 are individually selected from the group consisting of fluorine, chlorine, bromine, iodine, --CF.sub.3, --CN, --COOR and ##STR2## R is alkyl of 1 to 8 carbon atoms, Hal is chlorine, bromine or fluorine and R.sub.3 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms and residue of an alcohol used in pyrethrinoid synthesis having excellent pesticidal properties.

Abstract: An aqueous solution containing a mild concentration of organic acids, vitamin E acetate and a low concentration of aromatic oil to neutralize the caustic effects of alkaline cementitious materials such as concrete, stucco and the like on human skin. The solution restores a normal pH balance to the skin of those who have been exposed to either dry or wet alkaline cementitious materials.

Abstract: A method has been discovered for the control of arthropod pests which comprises treating the pest with an effective amount of selected fluorocarbons.

Abstract: A solution of DMSO and a body reactive agent (such as citric acid) is provided, and is typically topically applied to the body.

Abstract: Antidiarrheal compositions showing enhanced antidiarrheal activity comprise a non-steroidal anti-inflammatory drug compound and a polymeric hydroabsorptive agent. A patient in need of remedial or preventive treatment of diarrhea symptoms is administered an antidiarrheally effective amount of said antidiarrheal compositions.

Abstract: Pharmaceutical compositions of the prodrug type, a process for the preparation thereof, a process for the preparation of the as prodrug functioning compounds and compounds obtained herein.The pharmaceutical compositions of the invention contain organic acid anhydrides with formula 1 through 5, as well as the pharmacological acceptable salts thereof as prodrug functioning compounds, together with a suitable pharmaceutically acceptable gaseous, liquid or solid carrier.The prodrug systems of the invention possess as favorable property that they amend the residence time of the pharmaceutical composition in the body by influencing the transport system.Furthermore they increase the biological availability because of the more lipophilic properties of the anhydride compared with the acid, so that this improved administration performance may contribute to lower dosages.

Abstract: A solution of lidocaine hydrochloride, dimethyl sulfoxide and citric acid or citric acid monohydrate is prepared, for topical application to an animal or human.

Abstract: The invention provides an ointment composition for treating skin irritations such as diaper rash and decubitus. The composition includes zinc oxide, boric acid, karaya gum, peruvian balsam, cod liver oil and an appropriate solvent and pharmaceutical carrier.

Abstract: A concentrated aqueous solution of the sodium salt of methionine, which is practically free from inorganic salts, is produced from the medium resulting from the hydrolysis of 5-(.beta.-mercaptoethyl)hydantoin.

Abstract: Sarcosine and certain sarcosine derivatives, specifically N-low alkyl glycines with 1 to 4 carbon atoms in the N-alkyl part, their acid amides and sarcosine anhydride exhibit a tumor-inhibiting effect alone for themselves and mixed with one another, as well as a synergistic effect in combination with other tumor-inhibiting compounds, in particular antineoplastic alkylating compounds, intercalating substances, antimetabolites and plant substances.

Abstract: Polyhalohydroxyisopropyl phenylalkanoic and phenylalkenoic acids, amides, and esters, such as methyl 2-methoxy-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]benzenepro panoate, are useful as antihypertensive agents.

Abstract: This invention relates to methods for the prophylactic and curative treatment of gastrointestinal and cardiovascular disorders and parasitic infections in humans and animals, using a class of hetrocyclic amidino substituted urea and thiourea compounds, a novel class of heterocyclic amidino substituted urea and thiourea compounds and pharmaceutical compositions and animal feed additives including the same.

Abstract: New aminosulfonic acids of the general formula I ##STR1## wherein n represents the figures 4, 5, or 6, prepared according to previously known processes and characterized by very good tolerance and valuable cardiovascular properties, serve for the therapy of dysrhythmia and are superior to procaine.

Abstract: A method of providing an ameliorating effect on the subjective symptoms and objective signs of a patient with heart failure comprising administering to said patient an effective amount of taurine.

Abstract: Eucalyptol is used to enhance skin permeation of bio-affecting agents.

Abstract: Sodium 1,4-dimethylisopropylazulene-3-sulfonate is stabilized by adding to a solution thereof, physiologically non-toxic additives and then removing or separating the solvent therefrom by spray drying or a lyophilization.

Abstract: A nail conditioning composition comprising an aqueous emulsion of sodium lauryl sulfate, urea and hydrolyzed animal protein in the aqueous phase and mineral oil, cholesterol and a lipid in the oil phase, said lipid being cetyl alcohol, cetyl palmitate or a base salt of palmitic or stearic acids. The composition moisturizes and imparts flexibility to the nail and softens the cuticle area.