Carboxylic Acid, Percarboxylic Acid, Or Salt Thereof (e.g., Peracetic Acid, Etc.) Patents (Class 514/557)
Higher fatty acid or salt thereof (Class 514/558)
Nitrogen other than as nitro or nitroso nonionically bonded (Class 514/561)
Benzene ring nonionically bonded (Class 514/568)
Cyclic carboxylic acid containing three to five carbons or cyclic percarboxylic acid containing three to five carbons or salt thereof (Class 514/572)
Polycarboxylic acid or salt thereof (Class 514/574)
  • Methods for decreasing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome in an infant, toddler, or child
    Patent number: 8877812
    Abstract: Disclosed are nutritional formulations including predigested fats that can be administered to preterm infants, infants, toddlers, and children for improving tolerance, digestion, and absorption of nutrients and for reducing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome. The predigested fats include fatty acid-containing monoglycerides and/or a fatty acid component.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: November 4, 2014
    Assignee: Abbott Laboratories
    Inventors: Chron-Si Lai, Keith A. Garleb, John B. Lasekan, Steven R. Davis
  • Hair growth and/or regrowth compositions
    Patent number: 8877762
    Abstract: The present disclosure relates to compositions containing certain pyrimidine compounds such as minoxidil and/or certain pyrimidine sulfate (inner salt) compounds such as minoxidil sulfate and especially compositions containing pyrimidine compounds in combination with an admixtures comprising at least one antioxidant, at least one organic acid and a select fatty acid mixture. The present disclosure also relates to use of the compositions to grow and/or regrow hair and/or prevent hair loss in mammals and particularly in humans.
    Type: Grant
    Filed: May 15, 2012
    Date of Patent: November 4, 2014
    Assignee: McNeil-PPC, Inc.
    Inventors: Longsheng Hu, Virginia Streusand Goldman, Josephine A. Minerva, Susan Wendling
  • Method for producing mechanically activated amorphous and amorphocrystalline compounds of gluconic acid calcium salt
    Patent number: 8877810
    Abstract: The invention relates to the mechanically activated amorphous and amorphocrystalline compounds and compositions based thereon. Crystalline gluconic acid calcium salt or its compound with excipients is treated in grinding activator devices either up to the input specific energy value of not greater than 10.4 kJ/g and achieving an amorphocrystalline state or up to the input specific energy value of no less than 10.5 kJ/g and achieving an amorphous state. The obtainable agents are assessed by means of X-ray diffraction, IR, NMR, EPR spectroscopy, mass- or chromato-mass-spectrometry, and a differential thermal analysis. The mechanically activated amorphous and amorphocrystalline compounds are used as an active principle for preparing pharmaceutical preparations.
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: November 4, 2014
    Inventors: Grigoriy Nikolaevich Konygin, Nikolaj Sergeevich Strelkov, Dmitriy Stanislavovich Rybin, Viktor Vladimirovich Pozdeev, Evgeny Petrovich Yelsukov, Dilara Rashiovna Sharafutdinova, Yuri Yakovlevich Efremov, Vladimir Yurievich Petukhov, Gabdrauf Gabdrashitovich Gumarov
  • COMPOSITIONS AND METHODS RELATING TO PROLIFERATIVE DISEASES
    Publication number: 20140322304
    Abstract: Anti-cancer compositions and methods are described herein. In particular, compositions including one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described. Methods for treatment of pathological conditions particularly cancer, in a subject using one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described herein.
    Type: Application
    Filed: July 10, 2014
    Publication date: October 30, 2014
    Inventors: Gavin P. Robertson, Raghavendra Gowda Chandagalu D., Subbarao V. Madhunapantula, Gajanan S. Inamdar, Omer F. Kuzu
  • Method for modulating stem cell growth
    Patent number: 8871752
    Abstract: In one embodiment, provided is a composition including a prostaglandin compound for modulating stem cell proliferation and/or differentiation in a mammalian subject. In another embodiment, the instant application is directed to a composition which includes a prostaglandin compound for modulating proliferation and/or differentiation of stem cells of a mammalian subject, in which the stem cells are contacted directly or indirectly with the composition of the invention.
    Type: Grant
    Filed: February 18, 2009
    Date of Patent: October 28, 2014
    Assignee: Sucampo AG
    Inventors: Ryuji Ueno, Sachiko Kuno
  • Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, method of making and use thereof
    Patent number: 8871780
    Abstract: The presently described technology provides phenylethanoic acid, phenylpropanoic acid, phenylpropenoic acid, a salt thereof, a derivative thereof or a combination thereof chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs or compositions of hydrocodone which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: October 28, 2014
    Assignee: KemPharm, Inc.
    Inventors: Travis Mickle, Sven Guenther, Christal Mickle, Guochen Chi, Jaroslaw Kanski, Andrea K. Martin, Bindu Bera
  • Detergents capable of cleaning, bleaching, sanitizing and/or disinfecting textiles including sulfoperoxycarboxylic acids
    Patent number: 8871807
    Abstract: The present invention relates to novel combined laundry detergent, bleach, and antimicrobial composition incorporating novel sulfoperoxycarboxylic acid compounds, and methods for making and using them. The sulfoperoxycarboxylic compounds used in compositions of the invention are storage stable, water soluble and have low to no odor. Compositions of the invention may be in the form of a liquid, a solid, or a gel. The sulfoperoxycarboxylic compounds useful in preparing compositions of the present invention can be formed from non-petroleum based renewable materials.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: October 28, 2014
    Assignee: Ecolab USA Inc.
    Inventors: David W. Gohl, Robert D. P. Hei, Thomas Merz, Peter Jens Forth, Matthias Kreysel, David D. McSherry, Junzhong Li, Jonathan P. Fast
  • Methods of reducing hair loss and/or facilitating hair growth and/or regrowth
    Patent number: 8871773
    Abstract: The present disclosure relates to methods of retarding hair loss or facilitating hair growth and/or regrowth. More specifically, the present disclosure relates to methods of using the disclosed compositions to increase the rate of terminal hair growth and/or regrowth in a mammal.
    Type: Grant
    Filed: June 3, 2013
    Date of Patent: October 28, 2014
    Assignee: McNeil-PPC, Inc.
    Inventors: Longsheng Hu, Virginia Streusand Goldman, Josephine A. Minerva, Susan Wendling
  • METHODS RELATED TO THE TREATMENT OF NEURODEGENERATIVE AND INFLAMMATORY CONDITIONS
    Publication number: 20140315785
    Abstract: The invention includes methods of neuroprotection, inducing release of neurotrophic factors, inhibiting the over-activation of innate immune cells, attenuating the toxin-induced death and/or damage of tissues, reducing inflammation, treating an inflammation-related condition, and inhibiting NADPH oxidase, that includes contacting or administering an effective amount of at least one compound of the invention that include: valproic acid, sodium butyrate, and salts thereof; opioid peptides; a peptide comprising the tripeptide GGF; and morphinans, such as naloxone, naltrexone, 3-hydroxy-morphinan and dextromethorphan.
    Type: Application
    Filed: July 3, 2014
    Publication date: October 23, 2014
    Inventors: Jau-Shyong Hong, Liya Qin, Guorong Li, Michelle Block, Wei Zhang, Po-See Chen, Giia-Shuen Peng
  • NOVEL SULPHUR CONTAINING LIPIDS FOR USE AS FOOD SUPPLEMENT OR AS MEDICAMENT
    Publication number: 20140316002
    Abstract: The present disclosure relates to lipid compounds of general formula (I) wherein R1 is chosen from a C10-C22 alkyl group, a C10-C22 alkenyl group having 1-6 double bonds, and a C10-C22 alkynyl group having 1-6 triple bonds; R2 and R3 are the same or different and may be selected from different substituents; Y is chosen from sulphur, sulfoxide, and sulfone; and X is a carboxylic acid or a derivative thereof, a carboxylic ester, a carboxylic anhydride, or a carboxamide; or a pharmaceutically acceptable salt, complex, or solvate thereof. The present disclosure also relates to pharmaceutical compositions and lipid compositions comprising such compounds, and methods of using such compounds such as for treating diseases related to cardiovascular, metabolic, and/or inflammatory diseases.
    Type: Application
    Filed: April 28, 2014
    Publication date: October 23, 2014
    Applicant: PRONOVA BIOPHARMA NORGE AS
    Inventors: Anne Kristin Holmeide, Ragnar HOVLAND, Morten BRÆNDVANG
  • Food formulation for aquatic animals with integrated targeted delivery of bioactive agents
    Patent number: 8865197
    Abstract: An encapsulated formulation for food and bioactive agent delivery to aquatic animals includes various combinations of nutrients, a digestion enhancer, bioactive agents, and a local absorption enhancer. The bioactive agents and absorption enhancer may be encapsulated within a delay layer for targeted release at an area of the digestive tract distinct from the region of nutrient release. The bioactive agents and absorption enhancer may be coated with a sticky coating so that they tend to adhere to the inner surfaces of the wall of the digestive tract, thereby localizing their release and enhancing their effect. Instead of bioactive agents themselves, precursors may be delivered so as to generate the bioactive agents locally. The encapsulated precursors of a specific bioactive agent are separately contained in capsules which themselves can be adhesive to one another.
    Type: Grant
    Filed: September 6, 2005
    Date of Patent: October 21, 2014
    Assignee: Israel Oceanographic and Limnological Research Ltd.
    Inventors: Amos Tandler, William Koven, Shalom Zemach
  • SULFOPEROXYCARBOXYLIC ACIDS, THEIR PREPARATION AND METHODS OF USE AS BLEACHING AND ANTIMICROBIAL AGENTS
    Publication number: 20140308366
    Abstract: The present invention relates to novel sulfoperoxycarboxylic acid compounds, and methods for making and using them. The sulfoperoxycarboxylic compounds of the invention are storage stable, water soluble and have low to no odor. Further, the compounds of the present invention can be formed from non-petroleum based renewable materials. The compounds of the present invention can be used as antimicrobials, and bleaching agents. The compounds of the present invention are also suitable for use as coupling agents.
    Type: Application
    Filed: June 27, 2014
    Publication date: October 16, 2014
    Inventors: Junzhong Li, Richard Staub, David D. McSherry, Keith G. Lascotte, Steven J. Lange, Frank Everts
  • ANTI-MICROBIAL COMPOSITIONS AND RELATED METHODS
    Publication number: 20140308265
    Abstract: The claimed invention is directed to compositions and methods effective in preventing microbial contamination or reducing microbial count associated with a contaminated surface, comprising a biocidal system comprised of a primary biocide, a pH buffer agent, a surfactant, all in an aqueous based carrier, wherein the compositions may be considered environmentally friendly.
    Type: Application
    Filed: November 6, 2012
    Publication date: October 16, 2014
    Inventors: Burt R. Sookram, John W. Veenstra
  • Therapy for MLL-rearranged leukemia
    Patent number: 8859502
    Abstract: Provided are methods for treating MLL-rearranged ALL by administering to a patient an HDAC inhibitor alone or in combination with a DNA demethylating agent. Also provided are methods of treating MLL-rearranged infant ALL. Methods of treating cells by these agents are also provided. Additionally, disclosed is a method for screening for compounds capable to treat MLL-rearranged ALL, in particular, MLL-rearranged infant ALL. In one embodiment, the HDAC inhibitor is romidepsin.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: October 14, 2014
    Assignee: Celgene Corporation
    Inventors: Ronald Stam, Dominique J. P. M. Stumpel
  • Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy
    Patent number: 8859619
    Abstract: Disclosed are formulations of gamma-hydroxybutyrate in an aqueous medium that are resistant to microbial growth. Also disclosed are formulations of gamma-hydroxybutyrate that are also resistant to the conversion into GBL. Disclosed are methods to treat sleep disorders, including narcolepsy, with these stable formulations of GHB. The present invention also provides methods to treat alcohol and opiate withdrawal, reduced levels of growth hormone, increased intracranial pressure, and physical pain in a patient.
    Type: Grant
    Filed: November 26, 2012
    Date of Patent: October 14, 2014
    Assignee: Jazz Pharmaceuticals, Inc.
    Inventors: Harry Cook, Martha Hamilton, Douglas Danielson, Colette Goderstad, Dayton T. Reardan
  • Compounds and methods for enhancing hair growth
    Patent number: 8859616
    Abstract: The present invention provides a method for stimulating hair growth in a mammalian species or converting vellus hair or intermediate hair to terminal hair or stimulating hair follicles to increase hair growth and one or more properties selected from the group consisting of luster, sheen, brilliance, gloss, glow, shine or patina of hair associated with the follicles or increasing one or more of: length, thickness, number, and density, of eyelash hair or eyebrow hair comprising applying to the skin of a patient a composition comprising an effective amount of an EP3 agonist or an EP4 agonist prodrug or a mixture thereof. Such compositions which are used in treating the skin or scalp of a human or non-human animal may comprise an effective amount of 3, 7 or 3 and 7 thia prostanoic acid. A mixture of 3,7-dithia PGE1 and 3,7-dithia PGE1-isopropyl ester is preferred for this treatment.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: October 14, 2014
    Assignee: Allergan, Inc.
    Inventors: Jenny W. Wang, David F. Woodward
  • PRESERVATIVE COMBINATIONS COMPRISING PROPIONIC ACID AND VANILLIN AND/OR CINNAMIC ACID
    Publication number: 20140302217
    Abstract: The present invention relates to a preservative system capable of protecting against spoilage by bacteria, yeasts and moulds in carbonated and non-carbonated beverages. In accordance with the invention this objective is realized with a preservative system comprising a combination of propionate with vanillin and/or cinnamate. Vanillin and propionate are both known for their anti mould action. However the dosages that are needed of the separate ingredients are too high for most applications. The present inventors found that potassium cinnamate at low concentrations has a positive effect on the inhibition of moulds in combination with vanillin and propionate. Moreover, the present invention, using a combination of vanillin, propionate and cinnamate accomplishes complete inactivation of all moulds at manageable sensory levels.
    Type: Application
    Filed: October 18, 2012
    Publication date: October 9, 2014
    Applicant: Purac Biochem B.V.
    Inventors: Eelco Anthonius Johannes Heintz, Kumar Saurabh
  • INHIBITORS OF RGS PROTEINS
    Publication number: 20140303199
    Abstract: G-protein coupled receptors are a diverse group that are the target of over 50% of marketed drugs. Activation of these receptors results in the exchange of bound GDP for GTP in the G? subunit of the heterotrimeric G-protein. The G? subunit dissociates from the ?/? subunits and both proceed to affect downstream signaling targets. The signal terminates by the hydrolysis of GTP to GDP and is regulated by Regulators of G-protein Signaling (RGS) proteins that act as GTPase Activating Proteins (GAPs). This makes RGS proteins potentially desirable targets for “tuning” the effects of current therapies as well as developing novel pharmacotherapies. The present invention provides a convenient assay for identifying modulators of RGS proteins that can be adapted for high throughput screening utilizing the colorimetric dye, malachite green, to detect free phosphate in the presence of a test compound.
    Type: Application
    Filed: April 4, 2014
    Publication date: October 9, 2014
    Applicant: University of Iowa Research Foundation
    Inventor: David Roman
  • Triple Combination Release Multi-layered Tablet
    Publication number: 20140302141
    Abstract: This invention pertains to a multi-layered tablet for a triple combination release of active agents to an environment of use. More particularly, the invention pertains to a multi-layered tablet (1) comprising two external drug-containing layers (2 and 3) in stacked arrangement with respect to and on opposite sides of an oral dosage form (4) that provides a triple combination release of at least one active agent. In one embodiment of the invention the dosage form is an osmotic device. In another embodiment of the invention the dosage form is a gastro-resistant coated core. In yet another embodiment of the invention the dosage form is a matrix tablet. In a different embodiment the dosage form is a hard capsule.
    Type: Application
    Filed: February 24, 2014
    Publication date: October 9, 2014
    Applicant: OSMOTICA KERESKEDELMI ES SZOLGALTATO KFT
    Inventors: FERNANDO G. TONEGUZZO, GLENN A. MEYER, Marcelo A. RICCI, Marcelo A. COPPARI, ANA C. PASTINI, GUSTAVO A. FISCHBEIN
  • Method for treating an inflammation or lesion caused by a virus
    Patent number: 8853272
    Abstract: A method for treating an inflammation or lesion caused by herpes virus, comprising topically applying to said inflammation or lesion a composition consisting essentially of a C1 to C3 monohydroxy alcohol or a C2 to C4 diol and a sufficient amount of an acid to adjust the pH of the composition to below 4.6. Topical administration of the composition is preferred and is effective in treating lesions associated infections by viruses such as Herpes simplex. Nasal deliverable forms are effective in treating symptoms due to viruses that cause the common cold. Pharmaceutical compositions for use in the present method are provided.
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: October 7, 2014
    Assignee: Topical Remedy, LLC
    Inventors: Thomas W. Konowalchuk, Jack Konowalchuk
  • Method for inhibiting activity and/or expression of matrix metalloproteinase, inhibiting phosphorylation of mitogen-activated protein kinase, and/or promoting expression of collagen using tormentic acid
    Patent number: 8853271
    Abstract: A method for inhibiting the activity of matrix metalloproteinase (MMP), inhibiting the expression of matrix metalloproteinase, inhibiting the phosphorylation of mitogen-activated protein kinase (MAPK), and/or promoting the expression of collagen in a mammal is provided.
    Type: Grant
    Filed: November 29, 2010
    Date of Patent: October 7, 2014
    Assignee: China Medical University
    Inventors: Jin-Bin Wu, Wen-Chuan Lin, Hui-Ya Ho, Sze-Ying Chen
  • Method for ameliorating pruritus
    Patent number: 8846039
    Abstract: A method for preventing, treating, or ameliorating pruritus caused by skin, mucosa, or systemic disorder. The method comprises administering to a subject with pruritus or topically applying to an affected area with pruritus an effective amount of a formulation consisting essentially of a phenylbutyric acid or short-chain fatty acid derivative and a pharmaceutically acceptable carrier, salt or solvate thereof.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: September 30, 2014
    Assignee: Asan Laboratories Company (Cayman), Limited
    Inventors: Yih-Lin Chung, Nam-Mew Pui, Wei-Wei Chang
  • COMPOSITION USING CROSS-LINKED HYALURONIC ACID FOR TOPICAL COSMETIC AND THERAPEUTIC APPLICATIONS
    Publication number: 20140286884
    Abstract: Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.
    Type: Application
    Filed: March 18, 2014
    Publication date: September 25, 2014
    Applicant: LUROMED LLC
    Inventors: Adelya K. Leshchiner, Nancy E. Larsen, Edward G. Parent
  • GLYCOGEN OR POLYSACCHARIDE STORAGE DISEASE TREATMENT METHOD
    Publication number: 20140288175
    Abstract: A method for treating glycogen storage disease by administering an effective amount of a composition that includes ketogenic odd carbon fatty acids that ameliorate the symptoms of these diseases.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 25, 2014
    Applicant: Baylor Research Institute
    Inventor: Charles R. ROE
  • REACTIVE SURFACE COATING HAVING CHEMICAL DECONTAMINATION AND BIOCIDAL PROPERTIES
    Publication number: 20140287154
    Abstract: Reactive compositions are provided, having biocidal and chemical decontamination/neutralization properties, comprising a hygroscopic polymer and an active, which are useful in a variety of commercial, healthcare and military applications and a wide variety of contaminants, including without limitation chemical and biological warfare agents. The reactive compositions are renewable or rechargeable after use by exposure to an additional application of the active and do not require removal, disposal or replacement of the originally applied composition. Methods for preparing and applying the reactive compositions are disclosed.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 25, 2014
    Inventors: Herbert J. Kaiser, Miranda C. Shaver, Timothy Lee Giddens
  • Antiseptic compositions and methods
    Patent number: 8840932
    Abstract: Antiseptic compositions, as well as methods of making and using, wherein the compositions include: an antimicrobial agent selected from the group consisting of iodine (I2), an iodophor, and a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to provide an available iodine concentration of at least about 0.25 wt-%; a hydroxycarboxylic acid buffer in an amount of at least about 5 wt-%; water; and an optionally substantive film-forming polymer.
    Type: Grant
    Filed: March 10, 2006
    Date of Patent: September 23, 2014
    Assignee: 3M Innovative Properties Company
    Inventors: Matthew T. Scholz, Danli Wang, Triet M. Lu, Dong-Wei Zhu
  • Method of using diketopiperazines and composition containing them
    Patent number: 8841307
    Abstract: The invention provides a method of inhibiting the effects of platelet activating factor (PAF). For instance, a disease or condition mediated by PAF (particularly inflammation) can be treated or platelet aggregation can be inhibited. The invention also provides a method of inhibiting the production and/or release of interleukin 8 (IL-8) by cells. The effects of PAF and the production and/or release of IL-8 are inhibited according to the invention by a compound of the formula: wherein R1 and R2 are defined in the application, or a physiologically-acceptable salt thereof. The invention also provides pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: October 4, 2011
    Date of Patent: September 23, 2014
    Assignee: Ampio Pharmaceuticals, Inc.
    Inventors: David Bar-Or, C. Gerald Curtis, Nagaraja K. R. Rao, Greg Thomas
  • Composition for repelling mosquitoes
    Patent number: 8841343
    Abstract: The present invention relates to a mosquito repellent comprises at least one or more mosquito repelling compound selected from the group consisting of citronellic acid, geranic acid and derivatives thereof in an effective amount to repel mosquitoes.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: September 23, 2014
    Assignee: Bio & Hnt, Inc.
    Inventors: Hyouk Il Kwoen, Kye Chung Park, Hyun Woo Oh
  • METHODS AND COMPOSITIONS FOR CLEANING AND DISINFECTING SURFACES
    Publication number: 20140275267
    Abstract: This application relates to methods and compositions for cleaning and disinfecting unclean surfaces that are contaminated, typically with bacteria, viruses, yeast and molds. Broadly speaking contaminated surfaces includes hard and soft surfaces such as those found in household environments, in industrial environments, and hospitals, as well as surfaces of food products such as fruits, vegetables and meat. Further, the compositions can be prepared with naturally occurring components that are classified as generally considered as safe (GRAS) by the US FDA and/or comply with National Organic Production (NOP) standards of the USDA and can therefore be used in situations where such a classification is required such as organic food production.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: MARIA BEUG-DEEB INC. DBA T&M ASSOCIATES
    Inventors: Maria U.D. BEUG-DEEB, Thomas M. DEEB
  • PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF FUNGAL INFECTIONS
    Publication number: 20140275254
    Abstract: There is provided pharmaceutical compositions suitable for topical application to the nail for the treatment of nail diseases such as onychomycosis, comprising a urea-based component, a diol component, such as propylene glycol, an organic acid component, such as lactic acid, and a triol component, such a glycerol. There is further provided methods of improving the storage stability of a pharmaceutical composition suitable for topical application to the skin and/or nails comprising such urea-based components, diol components, organic acid components, and, optionally, an aqueous base, which method comprises adding a triol component, such a glycerol, to that composition prior to said storage.
    Type: Application
    Filed: February 28, 2014
    Publication date: September 18, 2014
    Inventors: Ewa Karlsson, Sahar Feizollahi Ashkar, Peter Kaufmann
  • ANTIVIRAL COMPOSITIONS AND METHODS FOR INACTIVATING NON-ENVELOPED VIRUSES USING ALKYL 2-HYDROXYCARBOXYLIC ACIDS
    Publication number: 20140275255
    Abstract: The present invention is directed to antiviral compositions that provide efficacy against non-envelope viruses such as noroviruses. The antiviral compositions comprise an alkyl 2-hydroxycarboxylic acid and an effective amount of a sulfonated surfactant. The composition may be used as a topical on human skin, as a hand sanitizer or as a hard surface cleaning composition.
    Type: Application
    Filed: March 12, 2013
    Publication date: September 18, 2014
    Applicant: ECOLAB USA INC.
    Inventors: Daniel E. Pedersen, Hilina Emiru, Carter Martin Silvernail
  • Novel anti-neurodegenerative natural compounds isolated from Alpiniae Oxyphyllae Fructus and their total synthesis
    Publication number: 20140275236
    Abstract: This invention is directed to novel compounds isolated or derived from Alpiniae oxyphyllae fructus, chemically synthesized novel compounds, methods of preparing the novel compounds and uses thereof as neuroprotectants or drugs for treating neurodegenerative diseases such as Parkinson's disease.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Inventors: Ming Yuen LEE, Zaijun ZHANG, Guohui LI
  • Chiral compounds of varying conformational rigidity and methods of synthesis
    Publication number: 20140271488
    Abstract: Synthesis of compounds having varying degrees of conformational rigidity is obtained via a low cost, high yield and efficient synthetic reactions. The library of compounds is structurally diverse having at least one or more chiral centers and providing large numbers of compounds having building block diversity and substantial scaffold diversity. The compounds further provide a novel method for obtaining candidate therapeutic agents for prevention, treatment or diagnosis of diseases.
    Type: Application
    Filed: September 7, 2012
    Publication date: September 18, 2014
    Applicant: The Scripps Research Institute
    Inventors: Glenn C. Micalizio, Thomas Kodadek, Mohosin Sarkar
  • Delivery system for co-formulated enzyme and substrate
    Patent number: 8834865
    Abstract: The invention provides methods, compositions, systems, and kits that include an enzyme/substrate co-delivery system. The liquid delivery system includes at least one enzyme encapsulated in a water-soluble polymeric matrix and a substrate for the enzyme in a carrier liquid in which the polymeric matrix is insoluble. When water is added, the polymeric matrix is solubilized and enzyme is released from the matrix, permitting catalytic action upon the substrate.
    Type: Grant
    Filed: November 3, 2009
    Date of Patent: September 16, 2014
    Assignee: Danisco US Inc.
    Inventors: Nathaniel T. Becker, Michael Stoner, Mee-Young Yoon
  • Use of Ketogenic Compounds for Treatment of Age-Associated Memory Impairment
    Publication number: 20140256808
    Abstract: This invention relates to the field of therapeutic agents for the treatment of Age-Associated Memory Impairment (AAMI). In particular, the present invention utilizes compositions comprising at least one compound capable of elevating ketone body concentrations in a mammal (e.g., ketogenic compounds), administered in an amount effective for treatment or prevention of loss of cognitive function caused by reduced neuronal metabolism in AAMI. In one embodiment, the composition includes medium chain triglycerides (MCT). In another embodiment, the compositions are administered in the presence of carbohydrate. The present invention also relates to oral dosage forms, in particular, a nutritional drink comprising at least one compound capable of elevating ketone body concentrations in a mammal.
    Type: Application
    Filed: May 5, 2014
    Publication date: September 11, 2014
    Applicant: Accera, Inc.
    Inventor: Samuel T. Henderson
  • LOW MELTING PROPIONIC ACID DERIVATIVE PARTICLES FOR USE IN ORAL DOSAGE FORMS
    Publication number: 20140256810
    Abstract: Low melting propionic acid derivative particles that are free flowing and have significantly reduced or eliminated throat burn are disclosed. A method of manufacturing the low melting propionic acid derivative particles; dosage forms containing the low melting propionic acid derivative particles; methods of manufacturing the dosage forms; and methods of treatment using the dosage forms are also disclosed.
    Type: Application
    Filed: March 8, 2013
    Publication date: September 11, 2014
    Applicant: MCNEIL-PPC, INC.
    Inventors: Saumitra Bagchi, Murali K. Vuppala
  • Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
    Patent number: 8828978
    Abstract: The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: September 9, 2014
    Assignee: KemPharm, Inc.
    Inventors: Travis Mickle, Sven Guenther, Christal Mickle, Guochen Chi, Jaroslaw Kanski, Andrea K. Martin, Bindu Bera
  • Triterpene-containing oleogel-forming agent, triterpene-containing oleogel and method for producing a triterpene-containing oleogel
    Patent number: 8828444
    Abstract: The invention relates to an oleogel-forming agent which comprises at least one highly dispersed triterpene. The invention also relates to an oleogel which comprises a nonpolar liquid in an amount ranging from 80% by weight to 99% by weight based on the total weight of the oleogel and an oleogel-forming agent comprising a highly dispersed triterpene in an amount ranging from 1% by weight to 20% by weight based on the total weight of the oleogel. The invention also relates to a method for producing an oleogel.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: September 9, 2014
    Assignee: Birken AG
    Inventor: Armin Scheffler
  • METHODS FOR IMPROVING BRAIN DEVELOPMENT AND COGNITIVE FUNCTION USING BETA-HYDROXY-BETA METHYLBUTYRATE
    Publication number: 20140249223
    Abstract: Disclosed are methods for enhancing neural function in an individual, such as an older adult. The methods include administering nutritional compositions comprising HMB to the individual. The nutritional compositions provide benefits for individuals that have or may be at risk of having cognitive decline, cognitive impairment, and neural dysfunction, typically resulting from cognitive diseases associated with neurodegenerative diseases.
    Type: Application
    Filed: February 13, 2012
    Publication date: September 4, 2014
    Applicant: ABBOTT LABORATORIES
    Inventors: Jose Maria Lopez Pedrosa, Manuel Manzano Martin, Alejandro Barranco Perez, Maria Ramirez Gonzalez, Ricardo Rueda Cabrera
  • METHOD OF ADMINISTRATION OF GAMMA HYDROXYBUTYRATE WITH MONOCARBOXYLATE TRANSPORTERS
    Publication number: 20140249115
    Abstract: One embodiment of the present invention is to improve the safety and efficacy of the administration of GHB or a salt thereof to a patient. It has been discovered that the concomitant administration of an MCT inhibitor, such as diclofenac, valproate, or ibuprofen, will affect GHB administration. For example, it has been discovered that diclofenac lowers the effect of GHB in the body, thereby potentially causing an unsafe condition. Furthermore, it has been discovered that valproate increases the effect of GHB on the body, thereby potentially causing an unsafe condition.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 4, 2014
    Applicant: Jazz Pharmaceuticals, Inc.
    Inventor: Jazz Pharmaceuticals, Inc.
  • METHOD OF ADMINISTRATION OF GAMMA HYDROXYBUTYRATE WITH MONOCARBOXYLATE TRANSPORTERS
    Publication number: 20140249222
    Abstract: One embodiment of the present invention is to improve the safety and efficacy of the administration of GHB or a salt thereof to a patient. It has been discovered that the concomitant administration of an MCT inhibitor, such as diclofenac, valproate, or ibuprofen, will affect GHB administration. For example, it has been discovered that diclofenac lowers the effect of GHB in the body, thereby potentially causing an unsafe condition. Furthermore, it has been discovered that valproate increases the effect of GHB on the body, thereby potentially causing an unsafe condition.
    Type: Application
    Filed: April 29, 2013
    Publication date: September 4, 2014
    Applicant: Jazz Pharmaceuticals, Inc.
    Inventor: Mark Eller
  • Long-chain carboxychromanols and analogs for use as anti-inflammatory agents
    Patent number: 8822529
    Abstract: Provided are long-chain carboxychromanol compounds useful for treating conditions associated with the need to inhibit cyclooxygenase-1, cyclooxygenase-2, and/or 5-lipoxygenase, and pharmaceutical formulations containing the compounds.
    Type: Grant
    Filed: September 17, 2009
    Date of Patent: September 2, 2014
    Assignee: Purdue Research Foundation
    Inventors: Qing Jiang, Richard Anthony Gibbs, Markus A. Lill
  • Topical ketoprofen composition
    Patent number: 8822537
    Abstract: A topical composition, specifically an oil-in-water emulsion, comprised of ketoprofen and oxybenzone in a physiologically acceptable topical carrier. The composition is applied topically to alleviate pain, especially pain associated with migraine headache. The composition has good photostability as well as freeze/thaw stability.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: September 2, 2014
    Assignee: Achelios Therapeutics, Inc.
    Inventors: Servet Buyuktimkin, Nadir Buyuktimkin, James L. Yeager
  • Dietary supplements containing terpenoid acids of maslinic acid or oleanolic acid and process for enhancing muscle mass in mammals
    Patent number: 8822536
    Abstract: A process for increasing lean body mass in a mammalian subject is provided that includes administering to the subject a purified quantity of maslinic acid, oleanolic acid, or a combination thereof. The administration can be orally and benefits from ingestion of an amino acid source such as dietary protein, oligopeptides, or amino acids. Administration within 2 hours of muscle-degrading exercise or on a daily basis for a period of time increases lean body mass.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: September 2, 2014
    Assignee: FHG Corporation
    Inventors: Augustin T. Romero, Tim Romero, Peter J. Miller
  • COMPOSITIONS FOR USE IN SURGERY
    Publication number: 20140243410
    Abstract: A method is provided for treating a subject in need of medication as an adjunct to elective surgery, comprising administration of a ketogenic material sufficient to produce a physiologically acceptable ketosis in the patient. Preferably the surgery is selected from the groups consisting of removal or section of tumours, removal of redundant organs such as lymph nodes and appendix, open heart surgery, cosmetic surgery, joint and bone surgery.
    Type: Application
    Filed: May 7, 2014
    Publication date: August 28, 2014
    Applicant: BTG International Limited
    Inventors: Keith Frank Martin, David John Heal
  • Composition for treating influenza a (HN) virus and a preparation method therefor
    Patent number: 8815949
    Abstract: New pharmaceutical compositions extracted from Ferula assa-foetida are confirmed to effectively treat influenza A (H1N1) virus. The extraction method of the new pharmaceutical compositions mainly includes steps of: (a) extracting F. assa-foetida with methanol to obtain a crude extract; (b) fractioning the crude extract with n-hexane-methanol to obtain a methanol extract; (c) fractioning the methanol extract with chloroform-water to obtain a chloroform extract; and (d) chromatographing the chloroform extract to obtain the pharmaceutical compositions, which can be further fractioned and chromatographed to obtain various sesquiterpene coumarins.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: August 26, 2014
    Assignee: Kaohsiung Medical University
    Inventors: Yang-Chang Wu, Fang-Rong Chang, Lien-Chai Chiang
  • Organic Compounds
    Publication number: 20140235722
    Abstract: The present invention relates to salts, polymorphs and hydrates of 2-Amino-2-[2-(4-C2-20-alkyl-phenyl)ethyl]propane-1,3-diol, and to the use thereof, in particular in the treatment or prevention of various autoimmune conditions.
    Type: Application
    Filed: February 13, 2014
    Publication date: August 21, 2014
    Applicant: NOVARTIS AG
    Inventors: Guido Jordine, Michael Mutz
  • Sulfoperoxycarboxylic acids, their preparation and methods of use as bleaching and antimicrobial agents
    Patent number: 8809392
    Abstract: The present invention relates to novel sulfoperoxycarboxylic acid compounds, and methods for making and using them. The sulfoperoxycarboxylic compounds of the invention are storage stable, water soluble and have low to no odor. Further, the compounds of the present invention can be formed from non-petroleum based renewable materials. The compounds of the present invention can be used as antimicrobials, and bleaching agents. The compounds of the present invention are also suitable for use as coupling agents.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: August 19, 2014
    Assignee: Ecolab USA Inc.
    Inventors: Junzhong Li, Richard K. Staub, David D. McSherry, Keith G. Lascotte, Steven J. Lange, Frank Everts
  • Hydrogen peroxide-based skin disinfectant
    Patent number: 8808755
    Abstract: A skin disinfectant in ready-to-use concentrated liquid or dry powdered form. Ready-to-use liquid forms have a pH of from about 2 to about 6 and include: (a) hydrogen peroxide in a concentration of from about 0.01 to about 4% w/w of the solution; (b) at least one surfactant chosen from imidazoline derivatives, alkyl betaines, alkyl amidopropyl betaine amides, alkyl amidopropyl betaines, alkylsulfo betaines, amine oxides and derivatives thereof in a concentration of from about 0.01 to about 15% w/w of the solution; (c) at least one hydrogen peroxide stabilizer in a concentration of from about 0.01 to about 4% w/w of the solution; (d) at least one member chosen from cyclic carboxylic acids and salts thereof in a concentration of from about 0.01 to about 4% w/w of the solution; and (e) at least one skin conditioning agent in a concentration of from about 0.01 to about 10% w/w of the solution.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: August 19, 2014
    Assignee: Virox Technologies Inc.
    Inventor: Navid Omidbakhsh
  • ORGAN PROTECTION SOLUTION AND ITS METHOD OF USE
    Publication number: 20140228436
    Abstract: An organ protectant solution which is intravenously administered includes a high concentration of cell-impermeant molecules and at least one oncotic agent. The cell-impermeant molecules preferentially load into the interstitial space and the oncotic agent(s) is/are restricted to the vasculature space. Together, they promote transfer of water from cells to interstitium and into the capillaries, thereby preventing or reducing cell swelling, and maintaining blood circulation and oxygenation of tissues. The organ protectant solution extends the “Golden Hour” for traumatic and/or hemorrhagic shock patients, thereby allowing more time for those patients to reach a point of care facility to receive medical treatment.
    Type: Application
    Filed: April 16, 2014
    Publication date: August 14, 2014
    Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventor: Martin MANGINO