R Is Acyclic Patents (Class 514/625)
Nitrogen in r (Class 514/626)
Carbon to carbon unsaturation in r (Class 514/627)
Halogen bonded directly to carbon in r (Class 514/628)
R is hydrogen or a lower saturated alkyl of less than seven carbons (Class 514/629)
  • N-alkyl-4'-hydroxyacetanilides, pharmaceutical compositions comprising them and their use
    Patent number: 4520134
    Abstract: N-alkyl-4'-hydroxyacetanilides wherein alkyl is of up to 8 carbon atoms, preferably ethyl or isopropyl, have analgesic, antipyretic, anti-inflammatory and sedative activity. Those of at least two carbon atoms lack the hepatotoxicity of acetaminophen and the N-methyl compound also has substantially less hepatotoxicity than acetaminophen. Pharmaceutical compositions comprising them are employed to ameliorate pain, reduce fever, reduce the symptoms of systemic inflammatory conditions and sedate.
    Type: Grant
    Filed: April 6, 1984
    Date of Patent: May 28, 1985
    Inventor: Gerald M. Rosen