Carbon To Carbon Unsaturation In R Patents (Class 514/627)
  • Patent number: 9796665
    Abstract: The present invention relates to a novel pseudoceramide derivative, a pharmaceutically acceptable salt thereof or a solvate thereof, and a pharmaceutical or cosmetic composition containing the same as an active ingredient. The novel pseudoceramide derivative of the present invention is expected to be very useful for treating or preventing skin diseases by activating cannabinoid receptors. In addition, the novel pseudoceramide derivative, the pharmaceutically acceptable salt thereof or the solvate thereof, of the present invention, has a simple synthesis process compared with a known cannabinoid receptor antagonist so as to reduce processing time and curtail material costs, and thus is economical, and has advantages such as easy emulsification during the formulation of cosmetic products or medical supplies.
    Type: Grant
    Filed: September 1, 2014
    Date of Patent: October 24, 2017
    Assignee: NEOPHARM CO., LTD.
    Inventors: Se Kyoo Jeong, Bong-Woo Kim, Jeong Eun Jeon, Bu-Mahn Park
  • Patent number: 9730986
    Abstract: The invention provides a method for alleviating discogenic pain by administering a therapeutic agent that disrupts neuronal and/or vascular elements in the disc, which is typically a degenerated disc. Disruption of neuronal elements in the disk includes destroying nerve endings without substantially affecting the central body of the nerve, suppressing activation of the nerve endings, and inhibiting the growth of nerve endings into the disk. Disruption of vascular elements includes causing the vascular extensions to retract from the disk, or suppressing the formation of such extensions. The therapeutic agent may be administered locally via an interbody pump, a bolus or a depot, or may be administered systemically.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: August 15, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Josee Roy, Susan J. Drapeau, Jeffrey C. Marx
  • Patent number: 9675727
    Abstract: The invention relates to a method for treating a subject for a bursitis. The method comprises applying to the skin surface covering a body part or region affected by the bursitis a composition capable of transdermally attracting fluids from the body part or region or its proximity, wherein the composition includes at least one adsorptive or absorptive agent, and leaving the composition in contact with the skin for sufficient time to allow the composition to transdermally absorb or adsorb at least a portion of the body fluids from the body part or region.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: June 13, 2017
    Assignee: MEDIWISE PTY LTD.
    Inventor: Danniel Jacques
  • Patent number: 9535071
    Abstract: The present disclosure provides methods and compositions that find use in facilitating a diagnosis of inflammatory liver disease in a subject. The methods and compositions generally involve detection of eotaxin-3 (E3) levels, either alone or with levels of eotaxin-1 (E1), and optionally, with levels of CCL22 and, further optionally, with levels of IL15. These levels can be used to facilitate a diagnosis of a liver disease of at least one of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC), and/or to facilitate a differential diagnosis between AIH, PBC, and PSC. The methods and compositions of the present disclosure also find use in facilitating treatment decisions for a subject.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: January 3, 2017
    Assignees: The Governors of the University of Alberta, Medizinische Hochschule Hannover
    Inventors: Abdolamir Landi, Michael Houghton, D. Lorne Tyrrell, Tim Lankisch, Tobias Weismueller, Michael Manns
  • Patent number: 9439418
    Abstract: Grease-like compositions are provided for repelling insects and preventing undesirable behavior in hoofed animals. The compositions utilize nontoxic mineral, synthetic, or vegetable oil based gels containing silica, clay, urea, polytetrafluoroethylene, or metallic soap thickeners and capsaicin.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: September 13, 2016
    Assignee: Pacific Tech Industries, Inc.
    Inventors: Richard Numata, Ryan Willey
  • Patent number: 9107407
    Abstract: Grease-like compositions are provided for repelling insects and preventing undesirable behavior in hoofed animals. The compositions utilize nontoxic mineral, synthetic, or vegetable oil based gels containing silica, clay, urea, polytetrafluoroethylene, or metallic soap thickeners and capsaicin.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: August 18, 2015
    Assignee: Pacific Tech Industries, Inc.
    Inventors: Richard Numata, Ryan Willey
  • Publication number: 20150133561
    Abstract: Capsaicinoid formulations and methods of treatment are disclosed herein which can be utilized to treat/attenuate pain in mammals. Typically, administration is via injection at a discrete site to provide pain relief for an extended period of time. The formulations are administered in a pharmaceutically acceptable vehicle. The formulations include an analgesic agent in an amount sufficient to attenuate the burning and hyperalgesic effects of capsaicinoid administration. The invention also includes a method of treating pain by administering a corticosteroid followed by administration of a capsaicinoid.
    Type: Application
    Filed: April 15, 2014
    Publication date: May 14, 2015
    Inventors: CHARLES A. BIRBARA, Philip J. Birbara, Daniel Bucks, Mary Coughlin
  • Publication number: 20150132238
    Abstract: Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.
    Type: Application
    Filed: January 23, 2015
    Publication date: May 14, 2015
    Inventors: Adelya K. Leshchiner, Nancy E. Larsen, Edward G. Parent
  • Publication number: 20150132237
    Abstract: Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.
    Type: Application
    Filed: January 23, 2015
    Publication date: May 14, 2015
    Inventors: Adelya K. Leshchiner, Nancy E. Larsen, Edward G. Parent
  • Publication number: 20150119369
    Abstract: The present invention relates to compositions including anhydrous compositions which include a dimethicone crosspolymer and/or dimethicone elastomer gum and one or more skin care products.
    Type: Application
    Filed: October 29, 2014
    Publication date: April 30, 2015
    Inventors: James Jeffries Harrison, Nohemi Harrison
  • Publication number: 20150119423
    Abstract: The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of local pain may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of moderate to severe pain, neuropathic pain, post herpetic neuralgia and rheumatic pains.
    Type: Application
    Filed: May 18, 2013
    Publication date: April 30, 2015
    Inventor: Mahesh Kandula
  • Patent number: 9012510
    Abstract: The present invention relates to the field of liquid crystals. Embodiments of the present invention relate to liquid crystals comprising at least one molecule within N-acyl ethanolamide (NAE) family, for example oleoylethanolamide (OEA), compositions comprising them and their possible uses.
    Type: Grant
    Filed: March 30, 2009
    Date of Patent: April 21, 2015
    Assignee: Nestec S.A.
    Inventors: Rafaele Mezzenga, Sayed Mohammady, Matthieu Pouzot
  • Publication number: 20150104498
    Abstract: The invention provides compositions, methods and kits for the removal of harmful or irritating substances from bodily surfaces. Kits may include a composition containing capsaicin and a capsaicin-cleansing composition, e.g., a composition in which capsaicin is soluble.
    Type: Application
    Filed: November 14, 2014
    Publication date: April 16, 2015
    Inventors: Arturo J. ANGEL, Larry W. LITLE, Keith R. BLEY, Allan L. WILCOX, Gene C. JAMIESON, Naweed MUHAMMAD
  • Publication number: 20150099015
    Abstract: Methods and compositions are provided for treating neuropsychiatric disorders such as schizophrenia, depression, attention deficit disorder, mild cognitive impairment, dementia, and bipolar disorder. The methods entail administering to a patient diagnosed as having a neuropsychiatric disorder (e.g., schizophrenia, depression, attention deficit disorder, mild cognitive impairment, dementia bipolar disorder, etc.) or as at risk for a neuropsychiatric disorder a benzoic acid, benzoic acid salt, and/or benzoic acid derivative, and/or a sorbic acid, sorbic acid salt, and/or sorbic acid derivative, in combination with a neuropharmacological agent (e.g., an antipsychotic, an antidepressant, medications for attention deficit and hyperactivity disorder, cognitive impairment, or dementia, etc.) where the benzoic acid, benzoic acid salt, or benzoic acid derivative, and/or a sorbic acid, sorbic acid salt, and/or sorbic acid derivative, is in an amount sufficient to increase the efficacy of the neuropharmacological agent.
    Type: Application
    Filed: November 24, 2014
    Publication date: April 9, 2015
    Inventor: Guochuan Emil TSAI
  • Publication number: 20150094374
    Abstract: Grease-like compositions are provided for repelling rodents. The compositions utilize nontoxic mineral, synthetic, or vegetable oil based gels containing silica, clay, urea, polytetrafluoroethylene, or metallic soap thickeners and capsaicin.
    Type: Application
    Filed: December 11, 2014
    Publication date: April 2, 2015
    Inventors: Richard Numata, Ryan Willey
  • Publication number: 20150079198
    Abstract: The present invention relates to a method and nutritional supplement which stimulates appetite and slows metabolism of a mammal, thereby enhancing weight gain for the mammal. The method of enhancing weight gain of the mammal comprises administering to the mammal an effective amount of at least two types of alkamide or isobutylamide compound extracted from Echinacea species along with an antioxidant and optionally minerals. The nutritional supplement of the present invention comprises an antioxidant and at least two types of alkamide or isobutylamide compounds derived from Echinacea species. Minerals such as zinc and magnesium can also be added to the nutritional supplement to provide even better effect.
    Type: Application
    Filed: September 13, 2013
    Publication date: March 19, 2015
    Inventors: Travis Kurt Alvord, Tyler Stevens Alvord
  • Publication number: 20150073056
    Abstract: Compositions are provided that contain a TRPV1 agonist, such as capsaicin, and a solvent system. Topical application of the composition results in rapid delivery of agonist to the dermis and epidermis. Method of using the compositions for reducing nociceptive nerve fiber function in subjects, and for treatment of capsaicin-responsive conditions are also provided.
    Type: Application
    Filed: April 17, 2014
    Publication date: March 12, 2015
    Applicant: ACORDA THERAPEUTICS, INC.
    Inventors: Naweed MUHAMMAD, Gene Curtis JAMIESON, Keith R. BLEY, Sanjay CHANDA
  • Patent number: 8940281
    Abstract: Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: January 27, 2015
    Assignee: LuroMed LLC
    Inventors: Adelya K. Leshchiner, Nancy E. Larsen, Edward G. Parent
  • Publication number: 20150025257
    Abstract: The invention describes novel mono or dihydroxy docosahexaenoic acid (DHA) analogues, their preparation, isolation, identification, purification and uses thereof.
    Type: Application
    Filed: June 8, 2012
    Publication date: January 22, 2015
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Charles N. Serhan, Rong Yang
  • Patent number: 8937100
    Abstract: Cosmetic compositions comprising calcium citrate and at least one N-acylated aminoalcohol according to formula (I). Provided is a method of treating aged skin, comprising topically applying to the aged skin a composition comprising a compound of Formula (I) in an amount effective to provide an anti-ageing effect. The compound of Formula (I) is used to prevent skin and/or to help to maintain or improve moisture retention and/or to fight against the signs of skin ageing. The N-acylated aminoalcohol of formula (I) acts as a ceramidase inhibitor. The combination of at least one compound of formula (I) and calcium citrate stimulates keratinocyte differentiation.
    Type: Grant
    Filed: October 22, 2013
    Date of Patent: January 20, 2015
    Assignee: Cognis IP Management GmbH
    Inventors: Philippe Moussou, Olga Freis, Louis Danoux, Philippe Grisoni, Laurent Bailly
  • Publication number: 20150017227
    Abstract: Disclosed are methods and compositions for treating skin diseases or conditions with a composition containing a lipid component as an active ingredient.
    Type: Application
    Filed: July 11, 2014
    Publication date: January 15, 2015
    Inventors: Byung Eui Kim, Donald Y.M. Leung
  • Publication number: 20150011642
    Abstract: Grease-like compositions are provided for repelling insects and preventing undesirable behavior in hoofed animals. The compositions utilize nontoxic mineral, synthetic, or vegetable oil based gels containing silica, clay, urea, polytetrafluoroethylene, or metallic soap thickeners and capsaicin.
    Type: Application
    Filed: September 19, 2014
    Publication date: January 8, 2015
    Inventors: Richard Numata, Ryan Willey
  • Publication number: 20140371321
    Abstract: A subject of the invention is a process for concentrating the spilanthol contained in a composition, comprising the formation of an addition compound of spilanthol with a strong acid, then the hydrolysis of said addition compound. The process according to the invention makes it possible to easily obtain a composition which may comprise 100% either isolated actual spilanthol ((2E,6Z,8E)-N-(2-methyl propyl)deca-2,6,8-trienamide), or a mixture of actual spilanthol with the isomers andor homologues thereof that may accompany it.
    Type: Application
    Filed: January 18, 2013
    Publication date: December 18, 2014
    Inventors: Andre Casazza, Karine Kormann
  • Publication number: 20140364400
    Abstract: The present invention relates to ophthalmic compositions and methods for the treatment of dry eye and other inflammatory ocular conditions. In particular, the present invention relates to a composition comprising an esterified anti-inflammatory lipid mediator, which is an ester of an anti-inflammatory lipid mediator that is a reaction product of the anti-inflammatory lipid mediator and a polyol wherein the majority of the anti-inflammatory lipid mediator is present in an ester form. In this way, the compositions are substantially free of an acid form of the anti-inflammatory lipid mediators. This composition can be topically delivered to the ocular surface via a preparation, solution, gel, ointment, and/or strip and/or a contact lens.
    Type: Application
    Filed: August 22, 2014
    Publication date: December 11, 2014
    Inventor: Annabelle Gallois-Bernos
  • Publication number: 20140343156
    Abstract: Described herein are compositions comprising capsaicin and methods of treating muscle cramping in a subject, comprising orally administering to the subject a composition comprising capsaicin and an excipient.
    Type: Application
    Filed: August 4, 2014
    Publication date: November 20, 2014
    Inventors: Bruce P. Bean, Donald MacKinnon, Roderick MacKinnon
  • Patent number: 8889113
    Abstract: The invention provides compositions, methods and kits for the removal of harmful or irritating substances from bodily surfaces. Kits may include a composition containing capsaicin and a capsaicin-cleansing composition, e.g., a composition in which capsaicin is soluble.
    Type: Grant
    Filed: August 28, 2012
    Date of Patent: November 18, 2014
    Assignee: Acorda Therapeutics, Inc.
    Inventors: Arturo J. Angel, Larry W. Litle, Keith R. Bley, Allan L. Wilcox, Gene Curtis Jamieson, Naweed Muhammad
  • Publication number: 20140336263
    Abstract: An animal deterrent device that generally includes a casing, a sensor, a power source and a deterrent means source. The animal deterrent device is used to provide protection to a target site, such as a carcass or part of a carcass left at or near the kill site from predatory animals and/or scavengers. Other uses for the device include preventing animals from disrupting trash or garbage receptacles or for preventing animals from gaining access to campsite rations, food, a temporary carcass or parts of a carcass storage area, or trash.
    Type: Application
    Filed: May 6, 2014
    Publication date: November 13, 2014
    Applicant: Grizzly Mountain Enterprises LLC
    Inventors: Dean Krebs, Shane Spencer
  • Publication number: 20140335150
    Abstract: The invention relates to a topical patch comprising a therapeutic compound-impermeable backing layer, a self-adhesive matrix based on polysiloxanes and containing capsaicin or a therapeutic compound analogous to capsaicin, and a protective film to be removed before use, in which the matrix contains liquid microreservoirs based on an amphiphilic solvent, in which the therapeutic compound is present in completely dissolved form and the concentration of the therapeutic compound in the microreservoir droplets is below the saturation concentration. The invention furthermore relates to a process for its production and its use in the treatment of neuropathic pain.
    Type: Application
    Filed: July 23, 2014
    Publication date: November 13, 2014
    Inventor: Walter Muller
  • Patent number: 8871814
    Abstract: Grease-like compositions are provided for repelling insects and preventing undesirable behavior in hoofed animals. The compositions utilize nontoxic mineral, synthetic, or vegetable oil based gels containing silica, clay, urea, polytetrafluoroethylene, or metallic soap thickeners and capsaicin.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: October 28, 2014
    Assignee: Pacific Tech Industries, Inc.
    Inventors: Richard Numata, Ryan Willey
  • Patent number: 8865685
    Abstract: The present invention relates to ophthalmic compositions and methods for the treatment of dry eye and other inflammatory ocular conditions. In particular, the present invention relates to a composition comprising an esterified anti-inflammatory lipid mediator, which is an ester of an anti-inflammatory lipid mediator that is a reaction product of the anti-inflammatory lipid mediator and a polyol wherein the majority of the anti-inflammatory lipid mediator is present in an ester form. In this way, the compositions are substantially free of an acid form of the anti-inflammatory lipid mediators. This composition can be topically delivered to the ocular surface via a preparation, solution, gel, ointment, and/or strip and/or a contact lens.
    Type: Grant
    Filed: June 13, 2012
    Date of Patent: October 21, 2014
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventor: Annabelle Gallois-Bernos
  • Publication number: 20140309273
    Abstract: Provided are new fatty acid derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, e.g., as agents for the treatment of obesity and related disorders, and for improving cognition.
    Type: Application
    Filed: June 25, 2014
    Publication date: October 16, 2014
    Applicants: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., AL-QUDS UNIVERSITY
    Inventors: Jehoshua KATZHENDLER, Meir SAIDIAN, Yousef NAJAJREH, Raphael MEVORACH, Elliot BERRY, Yosefa AVRAHAM
  • Publication number: 20140309302
    Abstract: A personal product antimicrobial preservative composition for preservation of topical personal care formulations is provided and includes [A] one or more undecylenic acid derivatives depicted by Formula (I), [B] one or more octanoic acid derivatives depicted by Formula (II), and [C] 2-phenoxy ethanol or 2-ethyl hexyl glyceryl ether or mixture of these two ‘liquid alcohol ethers’; wherein, each of the two components [A] and [B] is present in the range of 5 to 20% by weight and together [A] and [B] constitute 10 to 30% by weight and the ‘liquid alcohol ether’, component [C], is present 70 to 90% by weight of the total preservative composition. A method for preserving personal care product from microbial attack is provided containing an aqueous phase comprising three component composition from about 0.5 to 2.5% by weight of the total personal care formulation.
    Type: Application
    Filed: November 23, 2012
    Publication date: October 16, 2014
    Applicant: Galaxy Surfactants Ltd.
    Inventors: Nirmal Koshti, Shraddha Kiran Ratnaparkhe, Devyani Ashok Mali, Bhagyesh Sawant, Pooja Dinkar Vaidya
  • Publication number: 20140308338
    Abstract: A dressing for applying to the skin is characterized in that the adhesive mass is applied discontinuously in a strip or wave and contains an active substance.
    Type: Application
    Filed: August 29, 2012
    Publication date: October 16, 2014
    Applicant: BEIERSDORF AG
    Inventors: Jens Nierle, Karl-Heinz Woeller, Maxi Zier, Gerd Mueller
  • Publication number: 20140302183
    Abstract: This invention is formula and method for dispensing, injecting, or otherwise installing a formula comprising a mixture of compounds, foams, caulks, sealants, insulations, gels or other such mediums along with poisons, barriers, repellents, or deterrents in order to facilitate sealing or insulating as well as the additional benefit of killing, blocking, deterring, repelling or otherwise hindering said rodents, mammals, insects, and/or pests.
    Type: Application
    Filed: April 3, 2013
    Publication date: October 9, 2014
    Inventor: Dustin Alan Reynolds
  • Publication number: 20140286884
    Abstract: Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.
    Type: Application
    Filed: March 18, 2014
    Publication date: September 25, 2014
    Applicant: LUROMED LLC
    Inventors: Adelya K. Leshchiner, Nancy E. Larsen, Edward G. Parent
  • Patent number: 8840938
    Abstract: For enhancing bioavailability, a composition is administered comprising a Transient Receptor Potential cation channel subfamily V member 1 (TRPV1) agonist with a combined Scoville Heat Unit (SHU) milligram (mg) dose in the range of 280,000 to 400,000 SHU mg.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: September 23, 2014
    Inventor: W. Matthew Warnock
  • Publication number: 20140271873
    Abstract: A zero-calorie to near-zero-calorie snacking product that, when consumed, provides a feeling of fullness prior to absorption of energy-providing food, i.e., pre-absorptive satiation is disclosed. The snacking product is based on the stimulation of vagal nerve endings in the gastro-intestinal tract by encapsulated capsaicin. The encapsulation of capsaicin avoids the burning sensation in the mouth which may be objectionable to some consumers.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Applicant: Altria Client Services Inc.
    Inventors: Maria Gogova, Georgios D. Karles, Gerd Kobal, Munmaya K. Mishra
  • Publication number: 20140276484
    Abstract: Clay composite sheets, mats, films or membranes without polymers. Methods of preparing clay composite sheets, mats, films or membranes without using polymers in the method. Methods of using clay composite sheets, mats, films or membranes prepared without using polymers. Antimicrobial dressing having organo-modified clay product. Transdermal delivery of drugs using organo-modified clay product and methods.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: Materials Modification Inc
    Inventors: Kausik Mukhopadhyay, Krishnaswamy Kasthuri Rangan, Tirumalai Srinivas Sudarshan
  • Publication number: 20140255322
    Abstract: A siloxane polymer base that is useful as an excipient for many variable materials that can be compounded into it. Also disclosed are a method for the preparation of such bases, and another method regarding the preparation of the base and actives.
    Type: Application
    Filed: May 23, 2014
    Publication date: September 11, 2014
    Inventors: John D. Blizzard, Robert L. McKellar
  • Publication number: 20140234412
    Abstract: Suggested are new compositions for oral ingestion, comprising at least one active agent from the group of alkamides. The compositions which are orally ingested reduce the uptake of free fatty acids in the adipocytes and at the same time stimulate the release of serotonin and dopamine, which leads to a reduction of appetite, a feeling of satiety and a positive mood. In doing so, the new compositions are thus perfectly suitable to counteract any undesired gain of weight.
    Type: Application
    Filed: February 12, 2014
    Publication date: August 21, 2014
    Applicant: Symrise AG
    Inventors: Jakob Ley, Sabine Widder, Veronika Somoza, Barbara Rohm, Matthias Zaunschirm, Gerhard Krammer
  • Patent number: 8809395
    Abstract: The present invention is directed to compounds, intermediates and methods for making valerenic acid and its derivatives as well as the use of such compounds as GABAA receptor ligands.
    Type: Grant
    Filed: January 22, 2010
    Date of Patent: August 19, 2014
    Assignee: Valericon GmbH
    Inventors: Johann Mulzer, Jürgen Ramharter, Steffen Hering, Sophia Khom
  • Publication number: 20140228442
    Abstract: Grease-like compositions are provided for repelling rodents. The compositions utilize nontoxic mineral, synthetic, or vegetable oil based gels containing silica, clay, urea, polytetrafluoroethylene, or metallic soap thickeners and capsaicin.
    Type: Application
    Filed: April 18, 2014
    Publication date: August 14, 2014
    Applicant: Pacific Tech Industries, Inc.
    Inventors: Richard Numata, Ryan Willey
  • Publication number: 20140227200
    Abstract: The present application provides a synthetic spilanthol flavor composition that includes (2E,6Z,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide. The synthetic spilanthol composition can also contain, and at least one of (2E,6E,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide and (2E,6Z,8Z)—N-(2-methylpropyl)-2,6,8-decatrienamide, the (N-(2-methylpropyl)-2,6,8-decatrienamide being present in amounts effective to impart a salivating or tingle effect while reducing the perception of off notes, as compared to the off-notes perceived upon consumption of natural spilanthol (e.g. spilanthol obtained from jambu oleoresin). Methods of increasing salivation and/or providing a tingling sensation upon consuming an orally consumable product that include adding to the product a synthetic spilanthol flavor composition are also provided.
    Type: Application
    Filed: April 21, 2014
    Publication date: August 14, 2014
    Applicant: Takasago International Corporation
    Inventors: Louis Lombardo, Michael E. Lankin, Kenya Ishida, Shigeru Tanaka, Hideo Ujihara, Kenji Yagi, Jennifer B. Tartaglia, Carter B. Green, Amrit S. Mankoo
  • Patent number: 8802736
    Abstract: The present invention relates to a composition useful for pain relief. The composition is high concentration capsaicinoid topical composition comprising an analgesic agent that eliminates or reduces the burning or stinging sensation or erythema of the capsaicinoid.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: August 12, 2014
    Assignee: API Genesis, LLC
    Inventors: Daniel Bucks, Philip J. Birbara
  • Patent number: 8802735
    Abstract: The invention relates to solid pharmaceutical compositions comprising (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4?-trifluoromethylphenyl)-amide, as well as a process for the preparation of the same, methods of using such compositions to treat subjects suffering from autoimmune diseases in particular systemic lupus erythematosus or chronic graft-versus-host disease, multiple sclerosis or rheumatoid arthritis.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: August 12, 2014
    Assignee: Sanofi
    Inventor: Gerrit Hauck
  • Publication number: 20140205688
    Abstract: The present invention relates to a stimulating agent comprising a pungent component having astringency, a stimulating composition including the agent, as well as a flavor or fragrance composition, a food, a drink, an oral care product and an external skin preparation containing the agent or the composition, and also relates to the use of a pungent component having astringency as a stimulating agent. Examples of the pungent component having astringency include a plant extract of Asteraceae Spilanthes, Rutaceae Zanthoxyium, Rutaceae Fagara, or Piperaceae Piper, or an amide derivative represented by general formula (1) (where R1 represents an alkenyl group having 2 to 12 carbon atoms which may be substituted by a methylenedioxyphenyl at the end, R2 and R3 may be the same or different from each other and each are a hydrogen atom or a lower alkyl group in which a hydroxyl group may be substituted, and R2 and R3, together with the nitrogen atom adjacent thereto, may form a heterocyclic ring).
    Type: Application
    Filed: May 29, 2012
    Publication date: July 24, 2014
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Kaori Takahashi, Miyuki Takayanagi
  • Publication number: 20140199267
    Abstract: The invention provides methods for using fatty acid alkanolamides for ameliorating one or more symptoms or conditions caused by stress, e.g., loss of appetite, or for maintaining and enhancing nutrient and caloric intake by an animal under stress or that has experienced stress. Generally, the fatty acid alkanolamides in amounts of from about 0.1 to about 1500 mg/kg/day before, during or after stress, preferably on a regular or daily basis as a component of a food composition or as a dietary supplement.
    Type: Application
    Filed: August 7, 2012
    Publication date: July 17, 2014
    Applicant: Nestec SA
    Inventors: Delphine Tissot-Favre, Yuanlong Pan
  • Publication number: 20140200531
    Abstract: Aspects of the present invention concern the discovery of a transdermal delivery composition that can deliver low, medium and high molecular weight pharmaceuticals and cosmetic agents. Embodiments include transdermal delivery compositions with therapeutic and cosmetic application, transdermal delivery devices for providing said transdermal delivery compositions to subjects in need thereof, and methods of making and using of the foregoing.
    Type: Application
    Filed: December 19, 2013
    Publication date: July 17, 2014
    Applicant: JRX Biotechnology, Inc.
    Inventors: Frederick Jordan, Geoff E. Dolbear
  • Publication number: 20140193346
    Abstract: Herbal composition and method for the treatment of inflammatory pain associated with tendonitis, bursitis, arthritis, carpal tunnel syndrome, tennis elbow, plantar fasciitis, sports injuries, lower back pain and overexertion, gingivitis and muscle aches, that is compliant with HPUS monographs and/or over-the-counter FDA topical analgesic monograph requirements.
    Type: Application
    Filed: January 7, 2013
    Publication date: July 10, 2014
    Applicant: DRT LABORATORIES LLC
    Inventor: Ronit Arginteanu
  • Publication number: 20140193370
    Abstract: The invention provides methods for promoting lean body mass growth in an animal. The methods comprise administering OEA to the animals, preferably in amounts of from about 0.01 to about 1000 mg/kg/day.
    Type: Application
    Filed: May 8, 2012
    Publication date: July 10, 2014
    Applicant: NESTEC SA
    Inventors: Delphine Tissot-Favre, Yuanlong Pan, George Wells