Quaternary Ammonium Containing Patents (Class 514/642)
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Patent number: 6121289Abstract: This invention provides methods of treatment of addiction to tobacco comprising intranasal administration of nicotinic antagonists.Type: GrantFiled: October 9, 1998Date of Patent: September 19, 2000Assignee: Theramax, Inc.Inventor: Abdulghani A. Houdi
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Patent number: 6121327Abstract: A contact lens disinfecting solution which does not include protease, wherein an organic nitrogen disinfectant and 0.01-5 w/v % of at least one polyol are contained in an aqueous medium.Type: GrantFiled: May 21, 1999Date of Patent: September 19, 2000Assignee: Menicon Co., Ltd.Inventors: Akira Tsuzuki, Osamu Mori, Hideshi Nomura
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Patent number: 6103666Abstract: Compositions comprising an ionene polymer and a salt of dodecylamine are disclosed which are synergistically effective compared to the respective components alone in controlling the growth of microorganisms in or on a material or medium. Methods to control the growth of microorganisms with the use of the compositions of the present invention are also disclosed.Type: GrantFiled: September 10, 1998Date of Patent: August 15, 2000Assignee: Buckman Laboratories International, Inc.Inventors: Fernando Del Corral, Percy Jaquess, David Oppong
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Patent number: 6093564Abstract: Methods and compositions for selectively modifying nucleic acid molecules in biological compositions, including contacting the composition with an inactivating agent having the formula: ##STR1## where each of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.6, R.sub.7, and R.sub.8 is, independently, H or a monovalent hydrocarbon moiety containing between 1 and 4 carbon atoms, inclusive, provided that R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.6, R.sub.7, and R.sub.8 cannot all be H; R.sub.5 is a divalent hydrocarbon moiety containing between 2 and 4 carbon atoms, inclusive; X is a pharmaceutically acceptable counter-ion; and n is an integer between 1 and 10, inclusive are disclosed.Type: GrantFiled: January 12, 1998Date of Patent: July 25, 2000Assignee: V.I. Technologies, Inc.Inventors: Edward I. Budowsky, Samuel K. Ackerman, Andrei A. Purmal, Clark M. Edson
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Patent number: 6090619Abstract: The subject invention finds utility in the area of gene therapy of diseases. More specifically, the invention concerns the making of a novel non-viral vector which can bind to desired DNA to form a combination useful to transfect diseased mitochondria of human or animal cells. The non-viral vector comprises a dequalinium salt subjected to standard liposome production procedures to obtain the vector named DQAsomes.Type: GrantFiled: September 8, 1997Date of Patent: July 18, 2000Assignee: University of FloridaInventors: Volkmar Weissig, Jeffrey Allen Hughes, Jurgen Lasch, Thomas Cardon Rowe
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Patent number: 6090855Abstract: Quaternary ammonium carbonates having the formula ##STR1## wherein R.sup.1 is a C.sub.1 -C.sub.20 alkyl or aryl-substituted alkyl group and R.sup.2 is a C.sub.8 -C.sub.20 alkyl group have been synthesized.These compounds and compositions further comprising the corresponding quaternary ammonium bicarbonate ##STR2## wherein R.sup.1 is the same or a different C.sub.1 -C.sub.20 alkyl or aryl-substituted alkyl group and R.sup.2 is the same or a different C.sub.8 -C.sub.20 alkyl group and/or the corresponding quaternary ammonium metal carbonate ##STR3## wherein R.sup.1 is the same or a different C.sub.1 -C.sub.20 alkyl or aryl-substituted alkyl group; R.sup.2 is the same or a different C.sub.8 -C.sub.20 alkyl group and M is a non-coupler metal, are prepared by reacting two reactants, a C.sub.1 -C.sub.20 alkyl or aryl-substituted alkyl, C.sub.8 -C.sub.20 alkyl quaternary ammonium chloride and a metal hydroxide, in a solvent comprising a C.sub.1 -C.sub.4 normal alcohol.Type: GrantFiled: April 18, 1996Date of Patent: July 18, 2000Assignee: Lonza, Inc.Inventor: Leigh E. Walker
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Patent number: 6087303Abstract: Wood preservative systems comprising (a) a biocidal effective amount of (i) at least one di C.sub.8 -C.sub.12 alkyl quaternary ammonium carboxylate having the formula ##STR1## wherein R.sup.1 and R.sup.2 are a C.sub.8 -C.sub.l2 alkyl group; R.sup.3 is a substituted or unsubstituted, interrupted or uninterrupted C.sub.1 -C.sub.100 group; l and q independently are 1, 2 or 3 and (l) (q) is 1, 2, or 3; and n is 0 or an integer from 1 to 50; (ii) at least one di C.sub.8 -C.sub.12 alkyl quaternary ammonium borate having the formula ##STR2## wherein R.sup.1 and R.sup.2 are defined as above, and a is 2 or 3, but when a is 2, b is 0 or 1, and when a is 3, b is 0, 1, or 2; or (iii) a combination of (i) and (ii); and (b) a solvent are provided. These carboxylate quats as well as carboxylate quats wherein R.sup.1 is a C.sub.1 -C.sub.20 alkyl or aryl-substituted alkyl group and R.sup.2 is a C.sub.8 -C.sub.20 alkyl group are preferably prepared by an indirect or a direct synthesis.Type: GrantFiled: July 10, 1997Date of Patent: July 11, 2000Assignee: Lonza, Inc.Inventor: Leigh E. Walker
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Patent number: 6080789Abstract: A method for disinfecting a substrate is provided. The substrate is contacted with a biocidal effective amount of a composition of (a) at least one quaternary ammonium carbonate, bicarbonate, or any combination thereof; (b) a solvent selected from the group consisting of water and propylene glycol; and (c) optionally, a surfactant.Type: GrantFiled: September 16, 1997Date of Patent: June 27, 2000Assignee: Lonza, Inc.Inventor: Patrick J. Lutz
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Patent number: 6066674Abstract: A germicidal-disinfectant detergent composition comprising (a) a cationic germicide, (b) a metal chelating agent and (c) at least one surfactant selected from anionic surfactants, nonionic surfactants and amphoteric surfactants is described. Excellent detergency and germicidal action are provided.Type: GrantFiled: December 18, 1997Date of Patent: May 23, 2000Assignee: Kao CorporationInventors: Yuichi Hioki, Tadashi Moriyama, Chikako Matsumoto, Juri Sata, Yoshinori Tamura
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Patent number: 6051611Abstract: The invention relates to polymeric quaternary ammonium compounds which are useful as disinfectants and/or preservatives in ophthalmic compostions.Type: GrantFiled: December 22, 1998Date of Patent: April 18, 2000Assignee: Alcon Laboratories, Inc.Inventors: Evan P. Kyba, Joonsup Park
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Patent number: 6040346Abstract: The present invention provides a novel use of L-carnitine, the derivatives thereof and their pharmacologically acceptable salts in combination with antiretroviral drugs for reducing ceramide levels and enhance the activity of the aforesaid antiretroviral drugs for the therapeutic treatment of HIV-infection and AIDS.Type: GrantFiled: February 3, 1998Date of Patent: March 21, 2000Assignees: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Mendes s.r.l.Inventor: Sonia Moretti
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Patent number: 6034129Abstract: A method for treating a microbial infection in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising an amino group or an ammonium group attached to the polymer backbone via an aliphatic spacer group. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.Type: GrantFiled: June 24, 1996Date of Patent: March 7, 2000Assignee: GelTex Pharmaceuticals, Inc.Inventors: W. Harry Mandeville, III, Thomas X. Neenan, Stephen Randall Holmes-Farley
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Patent number: 6034117Abstract: This invention relates to a method for treating snoring, sleep apnea and other form of sleep-disordered breathing, which comprises administration of a therapeutically effective dose of an acetyl choline esterase inhibitor (CEI) such as pyridostigmine or a pharmaceutically acceptable salt thereof.Type: GrantFiled: September 21, 1998Date of Patent: March 7, 2000Inventors: Jan Hedner, Holger Kraiczi
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Patent number: 6031135Abstract: The invention relates to trimethylsphingosine derivatives which have some or all of the activities of the parent compound.Type: GrantFiled: May 13, 1996Date of Patent: February 29, 2000Assignee: Oncomembrane, Inc.Inventors: Fuqiang Ruan, Yasuyuki Igarashi, Sen-Itiroh Hakomori
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Patent number: 6028113Abstract: Solid sanitizing compositions have advantages over corresponding liquids and powders. A solid sanitizing product can be contained within a plastic bottle with a label indicating that the contents have antimicrobial or deodorizing properties containing a non-flowable solid composition having greater than about 0.02 percent by weight antimicrobial compounds. The preferred solid sanitizing compositions consist essentially of an antimicrobial compound selected from the group consisting of quaternary ammonium salts, fatty amines and diamines, chlorhexidine gluconate, phenol, derivatives of phenol, parachloro metaxylenol and mixtures thereof, and between 0 and 99.98 percent by weight of a cleaning composition. The solid sanitizing compositions can be effectively used with solid dispensers. The solid dispensers have a bowl with a drain at the bottom and an upward pointing spray nozzle.Type: GrantFiled: September 27, 1995Date of Patent: February 22, 2000Assignee: Sunburst Chemicals, Inc.Inventor: William H. Scepanski
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Patent number: 6028114Abstract: Use of at least one aminothiol ester derivative for the preparation of a pharmaceutical composition intended to increase the inhibition of a character resistant to the induction of apoptosis of transformed cells, this character being due to the bc12 gene present in these cells. The pharmaceutical composition is more particularly intended to treat pathologies chosen from breast cancers, B cell lymphomas, leukaemias, neuroblastomas, adenocarcinomas of the prostate, prolactinomas and other pituitary adenomas.Type: GrantFiled: May 25, 1999Date of Patent: February 22, 2000Assignee: Galderma Research & Development, S.N.C.Inventor: Gerard Quash
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Patent number: 6025399Abstract: A method for inducing neuromuscular blockade is described which is based on the administration to a surgical patient of an amount of a drug comprising tetrabutylammonium or a mixture of tetrabutylammonium and tetrapropylammonium which is effective to induce a neuromuscular block. In addition, there is disclosed the method of combining a non depolarizing muscle relaxant with the tetrabutylammonium or tetraproplyammonium compound to provide a neuromuscular block which requires a reduced dosage of both drugs.Type: GrantFiled: October 15, 1997Date of Patent: February 15, 2000Assignee: Montefiore Medical CenterInventors: Eva Marianne Travers, Judith Marilyn Dickson
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Patent number: 6022551Abstract: A rapidly acting antimicrobial alcohol-containing composition and method of using the composition to disinfect surfaces, such as the hands is disclosed.Type: GrantFiled: January 20, 1998Date of Patent: February 8, 2000Assignee: Ethicon, Inc.Inventors: Hanuman B. Jampani, Jerry L. Newman
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Patent number: 6015836Abstract: A new and improved formulation of a dual chain quaternary ammonium chloride compound and iodine/potassium iodide complex to serve as a disinfectant and sanitizer on surfaces and tissue as well as being utilized as an immersion solution in health care areas. The dual-quat with iodine formulation of the present invention is more useful over a wide range of areas and uses and is also more stable over a wide variety of water combinations. It improves efficacy, reduces toxicity, increases the spectrum of the antimicrobial effectiveness and broadens the effective usage of the complex into new areas of application.Type: GrantFiled: October 27, 1998Date of Patent: January 18, 2000Inventor: Howard Martin
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Patent number: 6001864Abstract: An antifungal composition including an imidazole-type antifungal compound and a quaternary ammonium salt is a medicament having a far more potentiated activity of miconazole nitrate and a higher therapeutic effect, and is effective against both Trichophyton and Candida.Type: GrantFiled: November 20, 1997Date of Patent: December 14, 1999Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Toshi Akashi, Shigeo Tanaka, Kimiko Sugita, Hideki Kohita, Michio Yamagishi, Kiyotaka Obata
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Patent number: 5998475Abstract: A non-toxic, environmentally safe and easily employable insecticide and insect repellant is achieved by providing an aqueous composition incorporating ethanolamine based compounds, either independently or in combination with the ethanolamine based compounds being selected from both simple compounds and conjugated compounds. In one preferred embodiment, a highly effective composition is attained for safe, effective, direct topical application to humans and animals by employing between about 10% and 70% by volume of the entire composition of the ethanolamine-based compound. In alternate preferred embodiments, the insecticide is formulated for application to plants, trees, crops, and other vegetation to provide a composition which effectively controls bothersome insects, while being completely safe and non-injurious to the plant, tree, or crop, as well as to the flowers or fruit thereof.Type: GrantFiled: March 20, 1997Date of Patent: December 7, 1999Inventors: Lynn Sue James, Michael A. Siedman
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Patent number: 5997893Abstract: The present invention provides antimicrobial compositions containing high levels of alcohol, carbomer polymers and antimicrobial agents. The present invention provides stable, high viscosity antimicrobial formulations possessing cosmetic characteristics.Type: GrantFiled: January 20, 1998Date of Patent: December 7, 1999Assignee: Ethicon, Inc.Inventors: Hanuman B. Jampani, Jerry L. Newman, Anthony W. Newman
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Patent number: 5994383Abstract: Antimicrobial compositions and methods for preparing and using same are provided. The antimicrobial compositions are surfactant-based and contain certain benzalkonium chloride homologs. The compositions are useful in treating infections in animals and humans, and can be applied to areas including the skin, nails, and mouth.Type: GrantFiled: November 18, 1997Date of Patent: November 30, 1999Assignee: Woodward Laboratories, Inc.Inventors: David L. Dyer, Kenneth B. Gerenraich
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Patent number: 5977183Abstract: Substantially solid (or nonflowable) antimicrobial compositions have advantages over corresponding liquids and powders. Such a composition may be contained within a plastic bottle with a label indicating that the contents have antimicrobial or deodorizing properties containing a substantially solid, non-flowable composition having greater than about 0.02 percent by weight antimicrobial compounds. The preferred compositions consist essentially of an antimicrobial compound selected from the group consisting of quaternary ammonium salts, fatty amines and diamines, chlorhexidine gluconate, phenol, derivatives of phenol, parachloro metaxylenol and mixtures thereof, and between 0 and 99.98 percent by weight of a cleaning composition. The compositions can be effectively used with solid dispensers. The solid dispensers have a bowl with a drain at the bottom and an upward pointing spray nozzle.Type: GrantFiled: January 10, 1997Date of Patent: November 2, 1999Assignee: Sunburst Chemicals, Inc.Inventor: William H. Scepanski
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Patent number: 5973108Abstract: Novel water-soluble homo- or copolymers are described which comprise 1,1-diallyl-3,4-dimethylenepyrrolidinium cations in the polymer and can additionally include 1,1-dialkyl-3,4-dimethylenepyrrolidinium cations. The polymers are prepared by first polymerizing a diallylammonium salt of the formula [(CH.sub.2 .dbd.CH--CH.sub.2).sub.2 NH.sub.2 ].sup.+ X.sup.- in which X.sup.- is the anion of any Bronstedt acid and, preferably, a halide, alone or together with an unsaturated comonomer, and reacting the resulting polymer or copolymer with a base and an allyl halide. The novel polymers are preferably used for treating textiles.Type: GrantFiled: May 11, 1998Date of Patent: October 26, 1999Assignee: Clariant GmbHInventors: Oliver Eyrisch, Guillermo Maier
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Patent number: 5973011Abstract: The present invention describes the use of nitric-oxide-liberating or transferring compounds, stimulators of endogenous NO formation, as well as stimulators of guanylate cyclase, for prevention, treatment and elimination of endothelial dysfunctions and the diseases accompanying these dysfunctions or caused by them, as well as the use of said compounds to produce pharmaceutical products for the cited areas of application.Type: GrantFiled: September 27, 1996Date of Patent: October 26, 1999Assignee: ISIS PHARMA GmbHInventors: Eike Albrecht Noack, Georg Kojda
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Patent number: 5968986Abstract: Antimicrobial nail coating compositions, and methods for treating and preventing microbial infections of the nail area, are provided. The antimicrobial nail coating compositions can be used to treat and/or prevent infections caused by microbes including bacteria, molds, spores, viruses and fungi, while providing a nail coating having acceptable handling and esthetic qualities. The compositions can include alcohol-containing solvents, and, as antimicrobial agents, quaternary amines or phenols.Type: GrantFiled: January 14, 1998Date of Patent: October 19, 1999Assignee: Woodward Laboratories, Inc.Inventor: David L. Dyer
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Patent number: 5958397Abstract: The present invention is directed towards a method, a composition and an article of manufacture for protecting the skin from jellyfish stings. The method comprises topically contacting the skin with a composition containing polymeric quaternary ammonium salt in amounts sufficient to protect against the rupture of jellyfish nematocysts. The composition can be in the form of an emulsion, liquid dispersion, solution, skin cream, face cream, lotion or ointment.Type: GrantFiled: July 21, 1997Date of Patent: September 28, 1999Assignees: Schering-Plough HealthCare Products, Inc., University of Maryland, BaltimoreInventors: Richard V. Smerbeck, James R. Johnson, Joseph W. Burnett, Jennifer E. Purcell
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Patent number: 5951988Abstract: Adjuvant formulations are provided containing quaternary ammonium salts in conjunction with an oil component which may be a mineral oil, an animal oil, a vegetable oil, a mixture thereof, or an oil-in-water emulsion of one or more of such oils. These formulations are useful in conjunction with known immunological substances, e.g., viral or bacterial antigens in a vaccine composition, in order to enhance the immunogenic response. The compositions are also useful without an incorporated antigen as nonspecific immunostimulatory formulations.Type: GrantFiled: June 5, 1995Date of Patent: September 14, 1999Assignee: University of SaskatchewanInventors: Sylvia van Drunen Littel-van den Hurk, Timothy Zamb, Mark J. Redmond
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Patent number: 5939461Abstract: The present invention provides a disinfecting composition which comprises: 1-5% of a quaternary nitrogen antibacterial agent preferably an alkyl aryl dimethyl ammonium salt of a monovalent anion, 0.5-5% of a terpenoid containing oil, preferably a pine oil and 0.1-3% of a nonionic surfactant selected from the group comprising:a) ethoxylated alcohols with an alkyl chain length of at least 16 carbons and an ethoxylation value of at least 21, preferably a C18-C20 ethoxylated alcohol with an ethoxylation value of 21-60 and,b) ethoxy/propoxy copolymers of molecular weight in excess of 4000.Type: GrantFiled: August 15, 1995Date of Patent: August 17, 1999Assignee: Lever Brothers CompanyInventor: Vera Lucia Siqueira
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Patent number: 5935927Abstract: The present invention relates generally to methods and compositions for treating amyloidogenic diseases such as Alzheimer's disease and the development of type II diabetes, in which deposition of amyloid in organs such as the brain and pancreas interfere with neurological function and insulin release, respectively. The methods and compositions are directed toward increasing the activity of scavenger cells within the body at recognizing and removing amyloid deposits from affected tissues and organs. Scavenger cells may be targeted to amyloid deposits by means of spontaneously-occurring chemical modifications called advanced glycosylation endproducts (AGEs). Compositions are described which increase scavenger cell activity towards AGE-modified amyloid.Type: GrantFiled: August 10, 1996Date of Patent: August 10, 1999Assignee: The Picower Institute For Medical ResearchInventors: Michael P. Vitek, Anthony Cerami, Richard J. Bucala, Peter C. Ulrich, Helen Vlassara, Xini Zhang
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Patent number: 5925681Abstract: Concentrated aqueous liquid disinfectant compositions which exhibit a blooming effect when diluted in a larger volume of water are provided. The concentrate compositions include non-phenolic constituents to provide a disinfecting effect, and are non pine-oil containing. Working strength dilutions of the concentrated aqueous liquid disinfectant compositions are effective against gram positive type pathogenic bacteria such as Staphylococcus aureus, as well as gram negative type pathogenic bacteria such as Salmonella choleraesuis.Type: GrantFiled: October 7, 1997Date of Patent: July 20, 1999Assignee: Reckitt & Colman Inc.Inventors: Michael George Crisanti, Dennis Thomas Smialowicz
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Patent number: 5922693Abstract: The present invention relates to an aqueous cleaning composition containing(a) 1 to 10 weight % of at least one surfactant selected from the group consisting of anionic surfactants and ethoxylated nonionic surfactants and mixtures thereof;(b) 0.2 to 10 weight % of a biostatic agent such as a C.sub.2 -C.sub.20 alkyl trimethyl ammonium halide, a C.sub.8 -C.sub.16 alkyl dimethyl benzyl ammonium halide, a polyhexamethylene biguanide hydrochloride, a 3-(trialkoxysilyl)propyl C.sub.14 -C.sub.20 alkyl dimethyl ammonium halide, ketoconazole, and zinc-bis(2-pyridinethiol 1-oxide); and(c) the balance being water; wherein said liquid cleaning composition does not contain a pigment, a chlorine containing bleach, peroxygen bleach, hydrogen peroxide, builder, water soluble or water dispersible organic binding agent, sequestering agent, acid dye, C.sub.8 -C.sub.18 fatty acid monoester of diglycerol, C.sub.8 -C.sub.Type: GrantFiled: February 20, 1998Date of Patent: July 13, 1999Assignee: Colgate-Palmolive Co.Inventor: Louis Oldenhove
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Patent number: 5919958Abstract: The present invention deals with the composition of matter and the utilization of certain novel amido amine salts of meadowfoam amido propyl dimethyl amine. These materials are useful in personal care applications.Type: GrantFiled: May 1, 1998Date of Patent: July 6, 1999Assignee: Fan Tech LtdInventor: Anthony J. O'Lenick, Jr.
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Patent number: 5910311Abstract: Cosmetic and/or dermatological compositions containing a non-photocatalytic metal oxide and tocopherol and, optionally, a metal-inactivating complexing agent are effective for inhibiting the light-induced peroxidation of lipids, and in particular lipids of sebaceous origin such as squalene.Type: GrantFiled: May 9, 1996Date of Patent: June 8, 1999Assignee: L'OrealInventors: Boudiaf Boussouira, Quang Lan Nguyen
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Patent number: 5908854Abstract: Disclosed are aqueous mycobacterial concentrate compositions at a pH in the range of 6 to 12 which comprises per 100% weight of a concentrate composition:a) from about 0.1% wt. to about 25% wt. of a germicidal cationic quaternary ammonium compound;b) from about 0.25% wt. to about 25% wt. of a solvent selected from: phenoxyalcohol, glycol ethers, or mixtures thereof; and,c) water.The concentrate compositions may be used in a ready to use form, or may be further diluted with water to form a disinfecting composition therefrom. The compositions may also include an effective amount of a pH adjusting agent, such as sodium hydroxide or triethanolamine. The compositions featuring reduced amounts of active constituents than those known to the art, and are particularly effective against Mycobacteriuin terrae.Type: GrantFiled: September 12, 1997Date of Patent: June 1, 1999Assignee: Reckitt & Colman Inc.Inventors: Karen Ann McCue, Narendra Nanavati, Timothy John Taylor
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Patent number: 5908866Abstract: The present invention relates to the use carbachol and other cholinergic substances for the treatment of keratoconjunctivitis sicca.Type: GrantFiled: August 7, 1997Date of Patent: June 1, 1999Assignee: Astra AktiebolagInventor: Rudolph Wolfgang Hahnenberger
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Patent number: 5907049Abstract: The present invention deals with the composition of matter and the utilization of certain amine oxides of meadowfoam amido propyl dimethyl amine. These materials are useful in personal care applications.Type: GrantFiled: May 11, 1998Date of Patent: May 25, 1999Assignee: Fan Tech LTDInventor: Anthony J. O'Lenick, Jr.
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Patent number: 5900157Abstract: Methods for controlling the fouling potential of macroinvertebrates are provided. An effective controlling amount of a polymer comprising a tannin and a cationic monomer is added to an aqueous system suffering from the fouling potential of macroinvertebrates.Type: GrantFiled: July 18, 1997Date of Patent: May 4, 1999Assignee: BetzDearborn Inc.Inventors: Joseph C. Petrille, Michael W. Werner
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Patent number: 5891921Abstract: Wood preservative systems comprising (a) a biocidal effective amount of (i) at least one di C.sub.8 -C.sub.12 alkyl quaternary ammonium carboxylate having the formula ##STR1## wherein R.sup.1 and R.sup.2 are a C.sub.8 -C.sub.12 alkyl group; R.sup.3 is a substituted or unsubstituted, interrupted or uninterrupted C.sub.1 -C.sub.100 group; l and q independently are 1, 2 or 3 and (l) (q) is 1, 2, or 3; and n is 0 or an integer from 1 to 50; (ii) at least one di C.sub.8 -C.sub.12 alkyl quaternary ammonium borate having the formula ##STR2## wherein R.sup.1 and R.sup.2 are defined as above, and a is 2 or 3, but when a is 2, b is 0 or 1, and when a is 3, b is 0, 1, or 2; or (iii) a combination of (i) and (ii); and (b) a solvent are provided. These carboxylate quats as well as carboxylate quats wherein R.sup.1 is a C.sub.1 -C.sub.20 alkyl or aryl-substituted alkyl group and R.sup.2 is a C.sub.8 -C.sub.20 alkyl group are preferably prepared by an indirect or a direct synthesis.Type: GrantFiled: April 18, 1996Date of Patent: April 6, 1999Assignee: Lonza Inc.Inventor: Leigh E. Walker
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Patent number: 5891922Abstract: A phase-stable, biocide concentrate and/or solution composition is provided for disinfecting surfaces such as in animal husbandry applications, food processing, medical purposes, and the like. In the concentrate form, the composition comprises a quaternary ammonium biocide, an aliphatic dialdehyde and a foam surfactant. Typically, the solution composition may employ glutaraldehyde, a foam producing surfactant, a chelating agent, an odor obscuring compound, and an acid to lower the pH and stabilize the glutaraldehyde. The concentrate has a stability at ambient temperature of up to about two years. When applied to surfaces employed in animal husbandry, the adhesive properties of the composition enable it to remain in contact with these surfaces a sufficiently long time and thereby provide effective cleaning and disinfecting capability.Type: GrantFiled: August 20, 1997Date of Patent: April 6, 1999Assignee: Preserve International, Preserve, Inc.Inventors: Gary E. Gaumer, Bruce A. Spielholz
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Patent number: 5880161Abstract: Therapeutic polyamines useful as a cancer chemotherapeutic agents, including molecules having a formula R.sub.1 --NH--(CH.sub.2).sub.x --NH-- (CH.sub.2).sub.x --NH-- (CH.sub.2).sub.y --NH--(CH.sub.2).sub.z --NH--R, wherein R.sub.1 and R.sub.2 are hydrocarbon chains having 1 to 5 carbons and w, x, y and z are integer of 1 to 10, are disclosed. One such molecule is N.sup.1, N.sup.19 -bis(ethylamino)-5,10,15-triazanonadecane, which is longer than spermine. This preferred compound may be used alone or in combination with other therapeutic agents, such as 1,3-bis(2-chloroethyl)-1-nitrosourea or cis-Pt.Type: GrantFiled: July 29, 1996Date of Patent: March 9, 1999Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Hirak Subhra Basu, Burt Feuerstein, Keijiro Samejima, Laurence Marton
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Patent number: 5853766Abstract: Wood preservatives contain a copper compound, an alkanolamine, a triazole, an emulsifier and/or a phosphonium compound and are used for impregnating wood.Type: GrantFiled: January 21, 1997Date of Patent: December 29, 1998Assignee: Dr. Wolman GmbHInventors: Reimer Goettsche, Hans-Volker Borck
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Patent number: 5849728Abstract: The subject invention relates to desquamation compositions comprising a combination of salicylic acid and certain zwitterionic surfactants. The subject invention further relates to methods of desquamation in mammalian skin and treating acne in mammalian skin.Type: GrantFiled: May 15, 1997Date of Patent: December 15, 1998Assignee: The Procter & Gamble CompanyInventor: Donald L. Bissett
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Patent number: 5843865Abstract: Compositions comprising an ionene polymer and a salt of dodecylamine are disclosed which are synergistically effective compared to the respective components alone in controlling the growth of microorganisms in or on a material or medium. Methods to control the growth of microorganisms with the use of the compositions of the present invention are also disclosed.Type: GrantFiled: February 6, 1997Date of Patent: December 1, 1998Assignee: Buckman Laboratories International, Inc.Inventors: Fernando Del Corral, Percy Jaquess, David Oppong
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Patent number: 5833741Abstract: The present invention provides a waterproofing wood preservative system comprising a waterproofer selected from the group consisting of an alkyl amine oxide, an alkyl acetoacetate, and a waterproofing quaternary ammonium compound and a biocide comprising at least one biocidal quaternary ammonium compound wherein said waterproofing quaternary ammonium compound is a C.sub.12 -C.sub.30 alkyl or C.sub.6 -C.sub.20 aryl-substituted alkyl, C.sub.12 -C.sub.30 alkyl quaternary ammonium composition and said biocidal quaternary ammonium compound is a C.sub.8 -C.sub.12 alkyl or C.sub.6 -C20 aryl-substituted alkyl, C.sub.8 -C.sub.10 alkyl quaternary ammonium composition. Said wood preservative system offers protection against both biological and physical decomposition of wood, as for example, that occurring in long term-weathering.Type: GrantFiled: January 16, 1997Date of Patent: November 10, 1998Assignee: Lonza Inc.Inventor: Leigh E. Walker
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Patent number: 5834516Abstract: The present invention deals with the composition of matter and the utilization of certain novel meadowfoam based betaine compounds. These materials are useful in personal care applications.Type: GrantFiled: May 1, 1997Date of Patent: November 10, 1998Assignee: Fan Tech LtdInventor: Anthony J. O'Lenick, Jr.
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Patent number: 5824812Abstract: Amine containing compounds and their use in the generation of cytofectin:polynucleotide complexes for transfection of cells, formulations, counterions, and reaction conditions for maximizing the transfection include using cationic amine compounds that have the general structure: ##STR1## wherein R.sub.4 and R.sub.5 are a pair of same or different lipoyl moieties selected from a group consisting of an alkyl, alkenyl, alkynyl, alkanoyl, alkenoyl, or alkynoyl groups and for R.sub.1, R.sub.2, and R.sub.3 at least two are hydroxylated, ether containing, or acyloxy containing alkyl, alkenyl, or alkynyl groups or at least one amine bonded halogen containing moiety selected from a group consisting of a halogenated alkyl, alkenyl, or alkynyl group or a mixture of at least one halogen containing moiety selected from a group consisting of a halogenated alkyl, alkenyl, or alkynyl group and at least one hydroxylated, ether containing, or acyloxy containing alkyl, alkenyl, or alkynyl group, and X.sup.Type: GrantFiled: September 17, 1996Date of Patent: October 20, 1998Assignee: The Regents of the University of CaliforniaInventors: Michael H. Nantz, Michael J. Bennett, Rajiv P. Balasubramaniam, Alfred M. Aberle, Robert W. Malone
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Patent number: 5789447Abstract: The present invention provides a method for treating oxygen free radical induced tissue damage associated with ischemia reperfusion injury, wherein nitric oxide is delivered to target cells/tissues through the administration of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen.Type: GrantFiled: September 12, 1995Date of Patent: August 4, 1998Assignees: The United States of America as represented by the Department of Health and Human Services, The Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: David A. Wink, Jr., James B. Mitchell, Angelo Russo, Murali C. Krishna, Ingeborg Hanbauer, Matthew B. Grisham, Daniel Neil Granger
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Patent number: 5783258Abstract: A method for treating lumber using a treatment composition having white mineral oil. The lumber is submerged in the treatment composition at atmospheric pressure or at an elevated pressure. The white mineral oil replaces moisture removed from the lumber, and thus lubricates the cell structure of the wood. The method is particularly well suited to the treatment of wood flooring blocks, since the white mineral oil is non-toxic and does not pose health or environmental hazards. A fungicide may be added to the treatment composition to inhibit the formation of mold.Type: GrantFiled: March 6, 1997Date of Patent: July 21, 1998Inventor: Ronald T. Garapick