Abstract: Precipitate-free aqueous compositions, well adapted as agricultural chemicals, e.g., crop protectants, are comprised of at least one water soluble cationic organic compound, e.g., a pesticidally active quaternary ammonium compound, and a thickening amount of a xanthan gum having an intrinsic viscosity of less than 3,500 cm.sup.3 /g.

Abstract: Efficacious aldehyde-free tuberculocidal liquid compositions which are odorless, less-toxic, and essentially irritant-free are disclosed. These compositions consist of a solvent containing a glycol ether and a quaternary ammonium salt and can be used in a method to disinfect and sanitize a variety of surfaces.

Abstract: Quaternary ammonium carbonates having the formula ##STR1## wherein R.sup.1 is a C.sub.1 -C.sub.20 alkyl or aryl-substituted alkyl group and R.sup.2 is a C.sub.8 -C.sub.20 alkyl group have been synthesized.These compounds and compositions further comprising the corresponding quaternary ammonium bicarbonate ##STR2## wherein R.sup.1 is the same or a different C.sub.1 -C.sub.20 alkyl or aryl-substituted alkyl group and R.sup.2 is the same or a different C.sub.8 -C.sub.20 alkyl group and/or the corresponding quaternary ammonium metal carbonate ##STR3## wherein R.sup.1 is the same or a different C.sub.1 -C.sub.20 alkyl or aryl-substituted alkyl group; R.sup.2 is the same or a different C.sub.8 -C.sub.20 alkyl group and M is a non-coupler metal, are prepared by reacting two reactants, a C.sub.1 -C.sub.20 alkyl or aryl-substituted alkyl, C.sub.8 -C.sub.20 alkyl quaternary ammonium chloride and a metal hydroxide, in a solvent comprising a C.sub.1 -C.sub.4 normal alcohol.

Abstract: The composite oxide comprises, by weight, 100 parts of zinc oxide and at least one member, incorporated therein, selected from seven specific oxides in their specific amounts such as 0.001 to 5.0 parts of lanthanum oxide, 1.0 to 10.0 parts of cobalt oxide, 1.0 to 30.0 parts of titanium oxide, the composite oxide being surface treated with a silicone oil or a fatty acid to provide a surface-treated composite oxide of the present invention which has excellent ultraviolet screening capability and high visible light transmittance, these superior properties being well balanced with each other, and can maintain said superior properties over a long period of time. In one embodiment, there is provided a process for producing the ultraviolet screening surface-treated composite oxide.

Abstract: Quaternary ammonium compounds having the structural formula: ##STR1## wherein X is chloride, bromide, iodide or alkyl carboxylate having a C.sub.1 -C.sub.18 alkyl radical, and R is n-nonyl or isononyl. The disclosed compounds were found to be non-toxic, low foaming, effective biocides in treatment methods for controlling bacteria, algae and molluscs in aqueous systems.

Abstract: Antimicrobial compounds of the formula ##STR1## wherein R, R.sup.1 and R.sup.2 are selected according to the following:A. R is (C.sub.11 -C.sub.16) alkyl (straight or branched), and R.sup.1 and R.sup.2 are joined to form a morpholine, pyrrolidine, or piperidine ring with the N;B. R is (C.sub.11 -C.sub.16) and R.sup.1 and R.sup.2 are independently selected from (C.sub.1 -C.sub.3) alkyl which in the case of C.sub.3 can be branched; andC. R.sup.1 and R.sup.2 are the same and are (C.sub.6 -C.sub.12) alkyl, straight or branched, and R is (C.sub.1 -C.sub.16) alkyl, straight or branched; andX.sup.- =an anion preferably selected from chlorine, bromine, iodine, phosphate, acetate, benzoate, citrate, tartrate, alkyl- or aryl-sulfonate, and alkylsulfate.

Abstract: A soybean lecithin based topical liniment and method of making the same is disclosed. The liniment utilizes soybean lecithin as a base and major ingredient and as the emulsifier which is mixed with plant oils, natural menthol, calcium stearate, and magnesium stearate. The soybean lecithin, plant oils, natural menthol, calcium stearate, and magnesium stearate are mixed together in predetermined relative proportions with the amount of soybean lecithin being greater than the sum of the amounts of the plant oils, natural menthol, calcium stearate, and magnesium stearate. The soybean lecithin, plant oils, natural menthol, calcium stearate, and magnesium stearate are added to one another and mixed together in a predetermined sequence to prevent precipitation and provide a homogenous mixture having a viscosity suitable for topical application.

Abstract: The color-stability of disinfectant formulations comprising bacteriocidal quaternary amine compounds, a non-ionic surfactant, and water is enhanced significantly by adding color-stabilizing amounts of an alkali bicarbonate. An alkali bicarbonate can be used in lieu of the art-accepted EDTA/NaOH builder in quaternary amine-based disinfectant formulations to enhance color stability without sacrificing the bacteriocidal efficacy of the formulations.

Abstract: A disinfectant or preservative composition particularly adapted for use in ophthalmic preparations such as contact lens disinfecting, cleaning, cushioning, wetting, soaking and reconditioning solutions and additionally in topical medications and tear substitutes, which uses a hydrophilic polymeric antimicrobial agent, namely poly[oxyethylene(dimethylimino) (ethylene dimethylimino)ethylene dichloride] with additional agents including EDTA and alkali salts thereof and a boric acid/borate buffer system.

Abstract: A sanitizer composition comprising a bactericidal effective amount of the combination of (a) a quaternary ammonium compound selected from the group consisting of (hydrogenated tallow) 2-ethylhexyl dimethyl ammonium salt, dicoco dimethyl ammonium salt, and mixtures thereof; and (b) a copper (II) ion source.

Abstract: Synergistic combinations of ionene polymers and hexahydro-1,3,5-tris(2-hydroxethyl)-s-triazine for use in controlling fungal and bacterial growth in synthetic metal working fluids.

Abstract: A method of inducing axial elongation of an eye of an animal comprising contacting a first open animal eye with a cholinergic agonist, detecting the change in axial growth of the first eye, applying a known control agent in a second open animal eye, observing the results of the control agent on the second eye, and comparing the change in axial growth of the first eye with the change in axial growth of the second eye.

Abstract: A biocide composition comprising(A) 1 to 50% by weight of a biocide, and(B) 0.005-60% by weight of a biocide activator having the specific formula is provided. The biocide effect of a biocide can be enhanced with the use of an effective amount of a biocide activator.

Abstract: Chemically stable granular insecticidal compositions of phosphoroamidothioates and phosphoroamidodithioates are provided. These compositions comprise at least 75 weight percent of ammonium sulfate effective for granulating the insecticidal components. Insecticidal methods employing these granules are also disclosed.

Abstract: The present invention relates to the use of thiadiazoles of the type ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 =hydrogen,alkyl groups having 1-4 carbon atomssubstituted alkyl groups having 1-4 carbon atoms which are substituted by halogen, carboxyl, hydroxyl or nitro group,an alkoxyCN, halogen, NO.sub.2 orCOOR in which R=H or alkyl groups 1-4 carbon atoms,and the use of synergistic combinations of thiadiazoles with other biocidal substances as biocides for material protection. The compounds according to-the invention, which are distinguished by a broad, biocidal action spectrum, can be used in particular for wood preservation for preventing the destruction of wood by fungi or bacteria, for the biocidal treatment of plastics and as preservatives or disinfectants. The recommended concentrations for use are 0.01 to 15 percent by weight-preferably 0.1-3.0 percent by weight.

Abstract: A biocidal, aqueous composition for killing bacteria, spores, fungi, and viruses on nonabsorbent surfaces comprises at least one quaternary ammonium compound, at least one aliphatic dialdehyde having from two to six carbon atoms, and at least one aliphatic hydroxyl compound having form one to eight carbon atoms.This sterilant is stable for weeks, is especially useful between pH 4 to 9, and may additionally comprise a chelating agent.

Abstract: A biocidal, aqueous composition for killing bacteria, spores, fungi, and viruses on nonabsorbent surfaces comprises at least one quaternary ammonium compound, at least one aliphatic dialdehyde having from two to six carbon atoms, and at least one aliphatic hydroxyl compound having form one to eight carbon atoms.This sterilant is stable for weeks, is especially useful between pH 4 to 9, and may additionally comprise a chelating agent.

Abstract: A moisture activated, antimicrobial composition is provided which can be applied to any flexible material and in particular to woven or nonwoven textiles and disposable medical garments and masks. This composition, in a preferred embodiment, contains a quaternary ammonium compound/nonoxynol 9 complex as the pathogenic growth inhibitor.

Abstract: The invention relates to a novel compound, compositions and medicaments thereof and a method of inhibiting cell proliferation, platelet aggregation (induced by various factors) and inhibiting malignant phenotypes of tumor cells such as those having a metastatic property, and modulating cell adhesion molecule expression and function using said compound, composition or medicament. N,N,N-trimethylsphingosine shows superior cell proliferation inhibitory and anti-metastatic activity over related compounds.

Abstract: The present invention relates to trihalo alkyl sulfone and mixtures of bis(trichloro methyl) sulfone (BTCMS), a non-ionic surfactant and a cationic quaternary ammonium halide surfactant formulated as a stable solution in water. The method of formulation comprises adding the BTCMS to an aqueous system containing a nonionic surfactant and a cationic quaternary ammonium halide surfactant. These formulations are useful as biocides and present advantages over organic solvent based formulations.

Abstract: A water-soluble chromium-free wood preservative comprising at least one copper salt and an alkanolamine and a polymeric quaternary ammonium borate formed by simultaneous reaction of (A) an amine selected from the group consisting of ##STR1## wherein R.sub.1 is alkyl or alkenyl of 8 to 22 carbon atoms or when R.sub.2 and R.sub.3 are --(C.sub.2 H.sub.4 O).sub.x --H or --(C.sub.3 H.sub.6 O).sub.x --H, R.sub.1 is alkyl of 1 to 22 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 22 carbon atoms, --(C.sub.2 H.sub.4 O).sub.x --H, --(C.sub.3 H.sub.6 O).sub.x --H and --CH.sub.2 --CH.sub.2 --NH.sub.2, R.sub.3 is selected from the group consisting of hydrogen, --(C.sub.2 H.sub.4 O).sub.x --H, --(C.sub.3 H.sub.6 O).sub.x --H and CH.sub.2 --CH.sub.2 --CH.sub.2 NH.sub.2, R.sub.4 and R.sub.6 are individually alkyl of 1 to 4 carbon atoms or --(CH.sub.2 H.sub.4 O).sub.x --H or --(C.sub.3 H.sub.6 O).sub.x --H, R.sub.5 and R.sub.2 are individually --(C.sub.2 H.sub.4 O).sub.x --H or -- (.

Abstract: The present invention relates to an anti-fouling coating composition that comprises a marine biocide and a binder which is a hydrolyzable film-forming seawater-erodible polymer. The polymer contains sulphonic acid groups in quaternary ammonium salt form.

Abstract: A disinfectant or preservative composition particularly adapted for use in ophthalmic preparations such as contact lens disinfecting, cleaning, cushioning, wetting, soaking and reconditioning solutions and additionally in topical medications and tear substitutes, which uses a hydrophilic polymeric antimicrobial agent, namely poly[oxyethylene(dimethylimino) (ethylene dimethylimino)ethylene dichloride] with additional agents including EDTA and alkali salts thereof and a boric acidborate buffer system.

Abstract: There is disclosed an oral composition including an organosilicon-type quaternary ammonium salt immobilized on a water-insoluble solid carrier. In particularly, an oral composition in an aqueous system according to the present invention includes an organosilicon-type quaternary ammonium salt immobilized on a water-insoluble solid carrier in combination with at least one surfactant selected from the group consisting of polyoxyethylene-polyoxypropylene block copolymers and alkylolamides as a stabilizing agent; at least one thickening agent selected from the group consisting of nonionic thickening agents and cationic thickening agents; and optionally at least one alcohol selected from the group consisting of ethanol, propanol and isopropanol as a dispersing agent.

Abstract: Quaternary ammonium compounds having the structural formula: ##STR1## wherein X is chloride, bromide, iodide or alkyl carboxylate having a C.sub.1 -C.sub.18 alkyl radical, and R is n-nonyl or isononyl. The disclosed compounds were found to be non-toxic, low foaming, effective biocides in treatment methods for controlling bacteria, algae and molluscs in aqueous systems.

Abstract: A fortified quaternary ammonium compound with and without dual synergistic phenols is provided for disinfection and sanitization. One formula consists of dual chain quaternary ammonium chloride (N-alkyl dimethylethylbenzyl ammonium chloride and N-alkyl dimethylbenzyl ammonium chloride), ortho phenyl phenol, para tertiary amyl phenol, citric or acetic acid, sodium citrate, isopropyl or ethyl alcohol, triethanol amine-HCl and water in the following proportions 50.00 to 0.50 grams, 1.00 to 0.08 grams, 1.00 to 0.08 grams, 0.50 to 0.05 grams, 0.25 to 0.025 grams, 14.00 to 1.40 grams, 5.00 to 1.00 grams, 28.25 to 96.865 grams. The formula for environmentally protected uses consists of dual chain quaternary ammonium chloride (N-alkyl dimethylethylbenzyl ammonium chloride and N-alkyl dimethylbenzyl ammonium chloride), citric or acetic acid, sodium citrate, isopropyl or ethyl alcohol, triethanol amine-HCl and water in the following proportions: 50.00 to 0.50 grams, 0.50 to 0.05 grams, 0.25 to 0.025 grams, 14.00 to 1.

Abstract: Ophthalmic compositions, such as those used to care for contact lenses, methods of preserving such compositions, and methods for disinfecting contact lenses using certain of such compositions are disclosed. The compositions may comprise an ophthalmically acceptable, liquid aqueous medium and, included therein, an effective preserving or disinfecting amount of a combination of certain oxygen-containing ionene polymers and other antimicrobial agents, preferably certain urea components.

Abstract: Salts of glycosaminoglycans (heparin, its fractions or fragments which are supersulfated, dermatan sulfate, heparan sulfate, and modified heparins) with bases of formula (I), ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4 represent H, alkyl, or cycloalkyl; R.sub.5 and R.sub.6 represent H, or alkyl; R.sub.7 and R.sub.8 represent H or alkyl; n and m are integers from 1-4 and X is --O--CO--O--, which salts have the pharmacological properties of the glycosaminoglycans themselves, and are orally and rectally administrable.

Abstract: A tubular foodstuff casing, in particular synthetic sausage casing, based on cellulose contains a di-n-didecyl-dimethylammonium compound as a fungicidal agent, which is optionally used in admixture with salts of sorbic acid, fungicidal heterocyclic compounds, such as an isothiazolone compound, or glycerol monolaurate. The coating prevents mold attack on the casing.

Abstract: A sanitizing composition for aqueous solutions comprising an dialiphatic dimethylammonium salt having an effective bactericidal activity at a concentration below about 50 ppm by weight in the medium to be sanitized during a maximum contact time not exceeding 60 seconds.

Abstract: A method of imparting antimicrobial activity to an ophthalmic composition includes the step of adding a polyquaternary ammonium salt to the composition. The method may be employed, for example, for disinfecting a contact lens or preserving a solution, ointment or suspension.

Abstract: Compositions and methods for dissolving calculi deposits in humans are disclosed. The compositions include solutions of quaternary ammonium salts and are particularly effective for the contact dissolution of pigment portions of biliary tract calculi such as gallstones. The solutions preferably further include mineral chelating agent and disulfide bond cleaving agent to aid in deaggregating mineral components and glycoprotein components of calculi.

Abstract: A wash solution having a pH of from about 7 to about 12 comprises at least about 0.1 weight percent of one or more cationic surfactants. This wash solution is useful in assays for chlamydial or gonococcal organisms, such as Chlamydia trachomatis or Neisseria gonorrhoeae. In particular, it can be used to remove uncomplexed materials from the insolubilized complexes formed between antigen and antibodies.

Abstract: A microbial inhibiting composition and method is disclosed. The composition comprises an amount, effective for the intended purpose of 2-bromo-2-nitropropane-1,3-diol and didecyl dimethyl ammonium chloride. The method comprises administering an amount of this combined treatment to the particular water containing system for which treatment is desired.

Abstract: A gel composition for cleaning and sanitizing the teats and udder of an agricultural animal for machine milking. Residual surface water, a source of milk contamination and mastitis, is eliminated from the teats and udder by use of the gel composition. The composition is constituted of water, a germicide added to the water in concentration sufficient to kill environmental bacteria which cause mastitis, and an aqueous gelling agent added to the water in concentration sufficient to form a palpable jelly-like mass, or gel. The composition preferably also includes a soap, detergent or other agent for the reduction of surface tension, and a skin softener and moisturizer. It preferably also contains a coloring agent. In application, the composition is applied to the teats and udder to soften and emulsify the particulate foreign matter, and kill the bacteria which cause environmental mastitis, without the separation therefrom of a separate liquid phase.

Abstract: The stabilization of aqueous or alkanolic solutions of choline and derivative of choline against discoloration on aging by the addition of an unsubstituted hydroxylamine salt to the choline solutions at levels of less than 1 percent.

Abstract: The process of disinfecting at least one of food, human beings, animals and products to be brought in contact with same to combat microorganisms includes (a) providing a microbicidal composition comprised of an effective amount of at least one microbicide which is hydrolyzable at a pH-value ranging from about 6 to about 8.5 and is a long-chain alkyl ester compound having the general formula: ##STR1## wherein R.sup.I, R.sup.II and R.sup.III are hydrogen or lower alkyl groups having 1 to 4 carbon atoms, R.sup.IV is a long-chain alkyl group having 10 to 18 carbon atoms, R.sup.V is hydrogen or a group having the formula R.sup.VI N.sup.+ H.sub.3, wherein R.sup.VI is an alkylene group having 3 to 4 carbon atoms, A is a monovalent counter ion, and n is a number of cationic groups in the long chain-alkyl ester compound; and (b) exposing microorganisms to the microbicidal composition to inactivate the microorganisms.

Abstract: A composition for enhancing the performance of animals, such as horses or dogs, is composed of adrenal and pituitary raw tissue concentrates, vitamin C, bioflavonoid complex, pantothenic acid, methionine, choline, vitamin B1, vitamin B2, vitamin B6, niacinamide, magnesium, vitamin B12, folic acid and organic iodine. The composition is adapted to be orally administered to an animal, is composed of all natural substances, and the relative proportions of the components are approximately:at least 40 parts adrenal raw tissue concentrate toat least 2 parts pituitary raw tissue concentrate to30-60 parts vitamin C to20-30 parts magnesium to10-20 parts of each of pantothenic acid, methionine and choline to8-15 parts of each of niacinamide and bioflavonoid complex to1-5 parts of each of vitamins B1, B2 and B6 to0.1-1 parts organic iodine to0.05-0.5 parts folic acid.

Abstract: An antimicrobial, low toxicity blend composition of several bis-quaternary ammonium compounds of defined structure, and in defined amounts of the composition, is described herein.

Abstract: Water-soluble wood preservatives which contain mixtures of a metal compound, a metal-fixing acid and a complexing polymeric nitrogen compound, and methods for protecting wood with such mixtures.

Abstract: A biocidal composition for the treatment of water comprises a cationic polyquaternary ammonium biocide, together with a source of transition metal cations e.g. copper II cations and/or a biocide of the type containing a gem. bromonitromethylene group e.g. 2-bromo-2-nitropropane-1,3-diol.

Abstract: Ophthalmic compositions, such as those used to care for contact lenses, methods of preserving such compositions, and methods for disinfecting contact lenses using such compositions are disclosed. The compositions may comprise an ophthalmically acceptable, liquid aqueous medium and, included therein, an effective preserving or disinfecting amount of an ophthalmically acceptable quaternary ammonium substituted matrix material, the matrix material being selected from the group consisting of proteinaceous materials, carbohydrate materials and mixtures thereof.

Abstract: A defoamer composition including a primary antifoam agent which includes a particulate-type material having a high surface area such as silica, a secondary antifoam agent for acting synergistically with the primary antifoam agent such as polydimethylsiloxane, a water carrier, and a quaternary ammonium salt silane compound which functions as an antimicrobial agent, fixed and adhered to the surface of the particulate material, in order that the defoamer composition be resistant to biological degradation due to the presence in the system of microorganisms. Methods of defoaming cationic, anionic, and nonionic surfactant produced foams are disclosed, as is a method of rendering silica hydrophobic.

Abstract: This invention pertains to a method of treating diseases caused by Herpes Simplex Virus (HSV) Types 1 and 2. Disclosed herein is a method of treatment that, through the use of Tetraethylammonium Ion (TEA) achieves a selective and specific inhibition of viral function in diseases caused by HSV Types 1 and 2. TEA can be provided in the form of its chloride salt, unpreserved for individual doese, or with preservatives for multiple dose vials.

Abstract: A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose of 2-(2-bromo-2-nitroethenyl) furan and didecyl dimethyl ammonium chloride. The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.

Abstract: The present invention relates to novel compounds represented by the formula: ##STR1## wherein R is an alkyl group having from about 8 to about 18 carbon atoms, and mixtures thereof, n has a value from 1 to 6, R.sub.1 is selected from the group consisting of an alkyl group having from 1 to about 12 carbon atoms, H, or ##STR2## wherein the sum of n-m=3 to 12, Z.dbd.H or SO.sub.3 M and M.dbd.NH.sub.4, Na, or K. These compounds possess antimicrobial activity and are useful as cleaning agents and preservatives, particularly in water-base functional fluids and surface coating compositions.

Abstract: Provided are cyclic hydrocarbons of Formula I ##STR1## with an aminoalkyl sidechain that are useful for treating phospholipase A2 mediated conditions, diabetes, and obesity.

Abstract: Ophthalmic compositions, such as those used to care for contact lenses, methods of preserving such compositions, and methods for disinfecting contact lenses using such compositions are disclosed. The compositions may comprise an ophthalmically acceptable, liquid aqueous medium and, included therein, an effective preserving or disinfecting amount of certain oxygen-containing ionene polymers.

Abstract: In a process for the elimination of germs, especially the removal of algae from water by means of water soluble quaternary ammonium compositions a polymeric salt of formula (I) ##STR1## wherein R is a C.sub.1 -C.sub.7 hydrocarbon group,m and n are a number of from 4 to 12 regardless of each other,x is a number of from 10 to 300, andhal is chlorine, bromine, or iodineis added to the water as the quaternary ammonium composition in an amount of more than 0.1 ppm and the process is carried out in the absence of heavy metal ions.

Abstract: The invention relates to a novel compound, compositions and medicaments thereof and a method of inhibiting cell proliferation, platelet aggregation (induced by various factors), and inhibiting malignant phenotypes of tumor cells such as those having a metastatic property, using said compound, composition or medicament. N,N,N-trimethylsphingosine shows superior cell proliferation inhibitory and anti-metastatic activity over related compounds.