Benzene Ring Containing Patents (Class 514/643)
  • Patent number: 10058094
    Abstract: This disclosure relates to anti-microbial sanitizer compositions and methods of making the same. The sanitizer compositions described herein are comprised of benzalkonium chloride, coconut oil, palm kernel oil, water, dihydroxypropyl PEG-5, linoleammonium chloride, and glycereth-2 cocoate. To forming the sanitizer compositions discussed herein, water is mixed with benzalkonium chloride to form a first mixture. This first mixture is then mixed with coconut oil and palm kernel oil to form a second mixture, which is subsequently heated to at least 100° F. After heating, the second mixture is mixed with dihydroxypropyl PEG-5 to form a third mixture, which is then settled while the temperature is maintained at or above 100° F. Thereafter, the third mixture is cooled to room temperature, and mixed with linoleammonium chloride and glycereth-2 coate to form the sanitizer composition.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: August 28, 2018
    Assignee: SANIT TECHNOLOGIES LLC
    Inventor: Joseph Giovanniello
  • Patent number: 9775345
    Abstract: This disclosure relates to anti-microbial sanitizer compositions and methods of making the same. The sanitizer compositions described herein are comprised of benzalkonium chloride, coconut oil, palm kernel oil, water, dihydroxypropyl PEG-5, linoleammonium chloride, and glycereth-2 cocoate. To forming the sanitizer compositions discussed herein, water is mixed with benzalkonium chloride to form a first mixture. This first mixture is then mixed with coconut oil and palm kernel oil to form a second mixture, which is subsequently heated to at least 100° F. After heating, the second mixture is mixed with dihydroxypropyl PEG-5 to form a third mixture, which is then settled while the temperature is maintained at or above 100° F., Thereafter, the third mixture is cooled to room temperature, and mixed with linoleammonium chloride and glycereth-2 cocoate to form the sanitizer composition.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: October 3, 2017
    Assignee: Sanit Technologies LLC
    Inventor: Joseph Giovanniello
  • Patent number: 9556109
    Abstract: The inventive subject matter relates to compounds of Formula I, compositions thereof, and processes for making such compounds as further described herein. The inventive compounds and compositions have antimicrobial properties and are useful as environmental disinfectants, topical cleansers such as topical personal care compositions, sanitizers, preservatives, in water treatment, as permanent or erodible coatings for medical devices and appliances, and in therapeutics. Additionally, the compounds of Formula I will serve as synthetic intermediates for making additional novel derivatives of triscationic amphiphile compounds.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: January 31, 2017
    Assignee: JAMES MADISON INNOVATIONS, INC.
    Inventors: Kevin L. Caran, Kyle Seifert
  • Patent number: 9314491
    Abstract: Provided, among other things, is a method of treating or ameliorating an indication of non-mucosal topical tissue comprising periodically applying to such disease affected tissue a composition comprising: an effective amount of an appropriate composition of herbal bioactive comprising active(s) of one or more of Sambucus nigra, Centella asiatica or Echinacea purpurea, and an effective amount of a quaternary ammonium surfactant.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: April 19, 2016
    Assignee: Izun Pharmaceuticals, Inc.
    Inventors: William Zev Levine, Aron Jay Saffer, Gabriel Nussbaum
  • Publication number: 20150148425
    Abstract: Materials and apparatus are provided that exhibit increased efficacy. An antimicrobial composition includes a cationic active ingredient disposed within the antimicrobial composition. Further, the antimicrobial composition includes a lauramine oxide surfactant, the lauramine oxide surfactant comprising 0.9 to 1.9 weight percent of the antimicrobial composition. Further, the antimicrobial composition includes a number of co-surfactants, the co-surfactant comprising cocamidopropyl betaine, sunfloweramidopropyl ethonium sulfate, PEG-120 methyl glucose dioleate, lauryl/myristyl amidopropyl amine oxide, lauramidopropylamine oxide, or combinations thereof. Still further, the antimicrobial composition includes a thickener, the thickener comprising hydromethylcellulose, PEG-120 methyl glucose, cocamide MEA, hydroxypropyl methylcellulose or combinations thereof.
    Type: Application
    Filed: November 25, 2013
    Publication date: May 28, 2015
    Applicant: The Dial Corporation
    Inventors: Janice L. Fuls, Nancy D. Rodgers
  • Publication number: 20150125407
    Abstract: The present invention relates to vesicular formulations for use in the topical administration of a biologically active agent, methods of administering a biologically active agent, a combined preparation comprising a vesicular formulation and a kit comprising a vesicular formulation.
    Type: Application
    Filed: May 10, 2013
    Publication date: May 7, 2015
    Applicant: Sequessome Technology Holdings Ltd
    Inventors: William Henry, Richard Wolf Garraway, John Mayo
  • Patent number: 8999399
    Abstract: The invention relates to a novel combined disinfection and decontamination agent comprising at least one vitamin, at least one metal ion, at least one active-surface compound, and at least one further antimicrobial active substance. The agent according to the invention surprisingly shows nearly complete nucleic acid disintegration in addition to an improved disinfectant effect. The agent can be successfully used as a combined decontamination and disinfection agent for skin, mucous membranes, hands, wounds, and/or hair, and instruments and surfaces of all kinds.
    Type: Grant
    Filed: November 14, 2009
    Date of Patent: April 7, 2015
    Assignee: Bose Chemie GmbH
    Inventors: Thomas Lisowsky, Sven Eggerstedt, Richard Bloss, Christiane Ostermeyer, Karlheinz Esser, Frank Bürger, Barbara Krug, Yvonne Feil, Kai-Martin Mueller, Delphine Haase
  • Patent number: 8999357
    Abstract: The present invention provides a composition having disinfectancy & residual antimicrobial activity, where the antimicrobial composition comprises an organosilane quaternary compound and a quaternary ammonium compound and other formulations. Also provided are methods of disinfecting an article or providing an antimicrobial coating to an article using the same.
    Type: Grant
    Filed: February 7, 2006
    Date of Patent: April 7, 2015
    Assignee: Sishield Technologies, Inc.
    Inventors: Jacques Elfersy, Marcello D. Villahoz
  • Patent number: 8999363
    Abstract: The present invention comprises methods and compositions for treating solid surfaces having antimicrobial and biocidal properties. Such surfaces are capable of controlling or killing a broad spectrum of biological agents, including viruses, bacteria and other microbial agents in solids, liquids or gases that subsequently contact the treated surface.
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: April 7, 2015
    Assignee: Sishield Technologies, Inc.
    Inventor: Jacques Elfersy
  • Publication number: 20150087717
    Abstract: The antimicrobial composition of the present invention comprises a cationic active ingredient, a quaternized sugar-derived surfactant, and an optional foam boosting surfactant. These formulations have a high cidal activity in a short amount of time and provide stable copious foam. The formulations of the present invention also exhibit enhanced tissue (e.g. skin) compatibility as defined by an in vitro whole toxicology assessment method.
    Type: Application
    Filed: December 5, 2014
    Publication date: March 26, 2015
    Inventors: Daniel E. Pedersen, Angela R. Eder, Charles Allen Hodge
  • Publication number: 20150079140
    Abstract: A cleaning composition for sanitizing and/or disinfecting hard surfaces, comprising: a cationic biocide, surfactant and low levels of VOC solvents. The cleaning composition is adapted to clean a variety of hard surfaces without leaving behind a visible residue and creates low levels of streaking and filming on the treated surface. The cleaning composition contains less than 5% by weight of VOCs. The cleaning composition may be used alone as a liquid or spray formulation or in combination with a substrate, for example, a pre-loaded cleaning wipe.
    Type: Application
    Filed: June 27, 2014
    Publication date: March 19, 2015
    Applicant: The Clorox Company
    Inventors: JANIECE HOPE, NANCY FALK, WENYU ZHANG, JARED HEYMANN, MONA KNOCK, MIKE KINSINGER, BERNARD HILL, VIDYA ANANTH
  • Publication number: 20150073051
    Abstract: An antimicrobial composition is provided that includes from about 0.1 to about 2 wt. % of a cationic antimicrobial agent selected from the group consisting of lauric arginate and benzalkonium chloride, based upon the total weight of the antimicrobial composition; from about 1 to about 10 wt. % of two or more nonionic surfactants selected from the group consisting of glucoside alkyl ethers and poloxamers, based upon a total weight of the antimicrobial composition; from about 0.1 to about 5 wt. % of an amine oxide, based upon the total weight of the antimicrobial composition; and one or more preservatives selected from phenoxyethanol, ethylhexyl glycerin, hexylene glycol, caprylyl glycol, and mixtures thereof.
    Type: Application
    Filed: March 14, 2013
    Publication date: March 12, 2015
    Inventors: Mitchell Cohen, James Bingham
  • Publication number: 20150064234
    Abstract: It has been discovered that pharmacological inhibition of K+ channels (using the FDA-approved broad-spectrum K+ channel antagonist 4-AP) positively benefitted smn mutant phenotypes, a result that is consistent with the defective excitability of motor circuits by their interneuron or sensory neuron inputs being a critical consequence of SMN depletion. Based on these observations, certain embodiments of the invention are directed to methods of treatment of SMA by administering therapeutically effective amounts of one or more potassium channel antagonists, including 4-aminopyridine, 4-(dimethylamino)pyridine, 4-(methylamino)pyridine, and 4-(aminomethyl)pyridine. Other embodiments are directed to new pharmaceutical formulations comprising two or more potassium channel antagonists.
    Type: Application
    Filed: March 26, 2013
    Publication date: March 5, 2015
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventor: Brian D. Mccabe
  • Publication number: 20150050366
    Abstract: Some embodiments of a system or method for applying a barrier composition to a targeted skin surface can be used to as a preventative measure to reduce the likelihood of transmission of microbial entities from an external source (e.g., a floor surface or another surface) to the targeted skin surface.
    Type: Application
    Filed: August 13, 2013
    Publication date: February 19, 2015
    Inventors: Aner Vlodaver, Benhoor Soumekh, Smarajit Mitra, Sumita B. Mitra
  • Patent number: 8956629
    Abstract: Disclosed is a dental composition, comprising unsaturated double bond-containing monomers and/or oligomers, a catalytic amount of polymerization initiator to initiate polymerization, and a filler, wherein the dental composition comprises an organic nanotube containing an antibacterial or anticariogenic material to inhibit or prevent tooth decay. The dental composition comprises an organic nanotube containing an antibacterial or anticariogenic material, thus uniformly and continuously exhibiting anticariogenic and antibacterial activities, while avoiding deterioration in physical properties required for the dental material.
    Type: Grant
    Filed: May 19, 2008
    Date of Patent: February 17, 2015
    Assignee: Vericom Co. Ltd
    Inventors: Myung-Hwan Oh, Won-Ho Kim, Mi Hyoun Ham, Jong-Hwi Lee, Yun-Ki Kim
  • Publication number: 20150045443
    Abstract: A water based, alcohol-free, skin sanitizing solution with a natural skin softener, where the nature of the biocidal enhancer used in the process of making the solution significantly increases efficacy while simultaneously enabling much more economical manufacturing, processing and transportation of the product. Because it is water based, no further moisturizing additives are required, and those with sensitive skin, diabetes, allergies or religious beliefs are able to use the product without concern.
    Type: Application
    Filed: August 12, 2013
    Publication date: February 12, 2015
    Applicant: APHEX BIOCLEANSE SYSTEMS, INC
    Inventor: David John Weaver
  • Publication number: 20150025153
    Abstract: Compounds and methods are provided for decreasing demyelinating inflammatory disease in a subject by inhibiting the activity of chemokine-like receptor 1 (CMKLR1). In some embodiments such methods include treating demyelinating inflammatory disease in a subject by administering an agent that antagonizes the activity of chemokine-like receptor 1 (CMKLR1) and/or a CMKLR1 ligand (e.g., chemerin or other endogenous CMKLR1 ligands). Candidate compounds include, without limitation, analogs and variants of 2-(alpha-naphthoyl)ethyltrimethylammonium iodide.
    Type: Application
    Filed: January 15, 2013
    Publication date: January 22, 2015
    Inventors: Kareem Graham, Jian Zhang, Eugene C. Butcher, Brian A. Zabel
  • Patent number: 8933128
    Abstract: The invention relates to the use of a composition for treating the surfaces of livestock buildings and/or the material therein in order to eliminate and/or inhibit pathogenic protozoa, and in particular coccidiosis oocysts. According to the invention, said composition essentially comprises the combination of an alkylamine and of a quaternary ammonium or of a quaternary ammonium derivative.
    Type: Grant
    Filed: February 5, 2009
    Date of Patent: January 13, 2015
    Assignee: CID Lines N.V.
    Inventors: Richard Alasri, Koen Brutsaert
  • Publication number: 20150011559
    Abstract: The invention provides methods of treating a bacterial infection in a mammal comprising administering to the mammal a compound of formula I: wherein A, B, and X have any of the meanings defined in the specification; or a pharmaceutically acceptable salt thereof, as well as novel compounds of formula I and salts thereof and pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: January 11, 2013
    Publication date: January 8, 2015
    Inventors: Edmond J. LaVoie, Ajit Parhi, Daniel S. Pilch, Yongzheng Zhang, Malvika Kaul
  • Publication number: 20150011641
    Abstract: The present invention relates to the field of carrier and delivery systems for active molecular compounds. In particular, the present invention provides aqueous dispersions for delivery of active molecular compounds.
    Type: Application
    Filed: September 22, 2014
    Publication date: January 8, 2015
    Inventors: Jai Supamahitorn, Lauren McMillan
  • Publication number: 20150001066
    Abstract: A wipe for anti-microbial disinfecting includes a flexible substrate and an anti-microbial ion source integrated on the substrate. The flexible substrate is made entirely or in part of woven fiber cloth, non-woven fiber cloth, woven synthetic cloth, non-woven synthetic cloth, or natural fiber cloth. The anti-microbial ion source is configured to dissolve in an aqueous solution to form an anti-microbial solution. The flexible substrate is configured to absorb the anti-microbial solution for use in cleaning.
    Type: Application
    Filed: June 25, 2014
    Publication date: January 1, 2015
    Inventor: Ashok V. Joshi
  • Publication number: 20140378550
    Abstract: Compositions containing a quaternary ammonium compound (QAC) “active” to provide an antimicrobial property, a quaternized phospholipid which provides a reduction in potential irritancy of other ingredients as well as foaming and cleansing properties, a second non-ionic or amphoteric surfactant (such as an alkyl amine oxide or linear alkyl polyglucoside) to provide increased foam volume and cleansing properties, a non-ionic or quaternized polymer (such as hydroxypropylmethylcellulose or hydroxypropyl guar hydroxypropyl trimonium chloride) which can provide thickening, foam structure and improved after-feel properties are described.
    Type: Application
    Filed: June 9, 2014
    Publication date: December 25, 2014
    Inventor: HEATHER GRUNDHOFER
  • Publication number: 20140348944
    Abstract: This invention relates to a “high lower alcohol content”(>40% v/v of a C1-4 alcohol) liquid composition able to be dispensed as a stable foam with the use of non-propellant foam dispensing devices from non-pressurized containers. The liquid compositions comprise an alcohol, C1-4 (>40% v/v), a silicone-based surfactant of at least 0.001% by weight to prepare a foamable composition, 0-10% w/w of additional minor components added to obtain the desired performance (a foamable composition), and the balance being purified water. The compositions may include emulsifier-emollients and moisturizers, secondary surfactants, foam stabilizers, fragrances, antimicrobial agents, other type of medicinal ingredients, and the like ingredients or additives or combinations thereof commonly added to alcohol gels or foams, aerosol compositions or to toiletries, cosmetics, pharmaceuticals and the like.
    Type: Application
    Filed: February 24, 2014
    Publication date: November 27, 2014
    Applicant: Deb Worldwide Healthcare Inc.
    Inventors: Maria Teresa Fernandez de Castro, Bruce Michael Koivisto, Francisco Munoz
  • Publication number: 20140343158
    Abstract: A stable, self-preserving, antimicrobial, composition suitable for the treatment of a variety of dermal as well as subcutaneous conditions. The compositions include as an active ingredient a quaternary ammonium compound, preferably benzethonium chloride, potentiated and synergized with menthyl lactate cooling agent in a cationic carrier. Optionally, a phenoxyethanol preservative and chlorhexidine digluconate antibacterial agent may be used to assist in enhancing the activity. The compositions kill a broad spectrum of gram-negative and gram-positive bacteria, fungus and yeasts. The compositions are used as first aid skin treatments and as skin sanitizers to help prevent bacterial contamination of minor cuts, scrapes and burns. The compositions are particularly useful when applied to the skin after hair removal in that they additionally cool, soothe and moisturize the skin.
    Type: Application
    Filed: November 2, 2013
    Publication date: November 20, 2014
    Inventor: Normajean Fusco
  • Publication number: 20140303100
    Abstract: This invention pertains to dental care compositions with antimicrobial benefits. In particular, the invention provides for compositions of oral tissue-adherent salts that release biocidal ions on a controlled release basis and thereby provide and maintain an essentially uniform concentration of biocidal ions above the MBC or MIC of the target bacteria at the site of application in the mouth for an extended period of time. The compositions are useful for treating or preventing oral diseases resulting from bacteria, fungal or yeast infections, such as caries, gingivitis, periodontal disease and candidiasis.
    Type: Application
    Filed: June 25, 2014
    Publication date: October 9, 2014
    Inventors: Anthony Errol Winston, Richard F. Stockel, Anthony Joseph Sawyer
  • Publication number: 20140303101
    Abstract: This invention pertains to dental care compositions with antimicrobial benefits. In particular, the invention provides for compositions of oral tissue-adherent salts that release biocidal ions on a controlled release basis and thereby provide and maintain an essentially uniform concentration of biocidal ions above the MBC or MIC of the target bacteria at the site of application in the mouth for an extended period of time. The compositions are useful for treating or preventing oral diseases resulting from bacteria, fungal or yeast infections, such as caries, gingivitis, periodontal disease and candidiasis.
    Type: Application
    Filed: June 25, 2014
    Publication date: October 9, 2014
    Inventors: Anthony Errol Winston, Richard F. Stockel, Anthony Joseph Sawyer
  • Publication number: 20140294906
    Abstract: In one embodiment, the invention relates to a method for rendering a non-metallic substrate stably antimicrobial. The method comprises: (a) contacting the substrate with an antimicrobial surfactant; (b) contacting the substrate with a polymeric binder; and (c) subjecting the substrate, surfactant, and binder to conditions at which the substrate becomes stably antimicrobial. In another embodiment, the invention relates to a substrate into which an antimicrobial surfactant and a binder have penetrated.
    Type: Application
    Filed: August 26, 2011
    Publication date: October 2, 2014
    Applicant: Research Foundation of the City University of New York
    Inventors: Robert Engel, Gary Innocenti, Karin Melkonian
  • Patent number: 8846725
    Abstract: Compositions and methods for treating disordered tissues, such as caused by pathogens and/or by toxins. The treatment compositions include an anti-infective active agent, a liquid carrier, and benzocaine in an amount so that the treatment composition penetrates more quickly into disordered tissue compared to the treatment composition in the absence of the benzocaine. In addition, the benzocaine can increase residence time of the anti-infective active in the treatment area. The preferred anti-infective active agent can be an organohalide, such as a quaternary ammonium halide compound, an example of which is benzalkonium chloride. The treatment compositions and methods may employ the use of an applicator adapted for use in promoting penetration of the treatment composition and/or agitation of the disordered tissue to further enhance penetration.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: September 30, 2014
    Assignee: Quadex Pharmaceuticals, LLC
    Inventors: B. Ron Johnson, James P. McCarthy
  • Publication number: 20140275248
    Abstract: Methods for treating molluscum contagiosum warts include identifying a human with one or more molluscum contagiosum warts and applying an anti-infective composition to the one or more warts. The anti-infective composition comprises at least one anti-infective agent in a liquid carrier, such as an organohalide. The liquid carrier includes a tissue penetrating component for rapid penetration of the anti-infective agent into the one or more molluscum contagiosum warts. Application of the anti-infective composition to molluscum contagiosum warts causes the warts to turn black and/or fall off the skin in less than about 5 days.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Inventor: B. Ron Johnson
  • Publication number: 20140274939
    Abstract: Kits and methods for treating disordered tissue caused by a virus in a mammal involve co-administration of a systemic anti-virus drug and topically administering an anti-infective composition. The systemic anti-virus drug is internally administered and disrupts or inhibits virus replication systemically within the mammal. Examples include nucleoside analogues, nucleoside analogue precursors, and nucleotide analogues. The topically administered anti-infective composition includes at least one anti-infective agent, such as an organohalide (e.g., benzalkonium chloride), and is formulated to penetrate below the disordered tissue surface and allow the anti-infective agent to kill viruses at the disordered tissue site. The anti-infective composition reduces the time and/or number of dosages required for the systemic anti-virus drug to treat the disordered tissue in the absence of topically administering the anti-infective composition. It also reduces or eliminates incidences of post-treatment neuralgia.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 18, 2014
    Applicant: QUADEX PHARMACEUTICALS, LLC
    Inventor: B. RON JOHNSON
  • Patent number: 8834857
    Abstract: A method for cleaning, benefiting, or deodorizing skin or hair utilizing a body wash, skin cleaner, soap, shampoo or deodorizer formulation containing a controlled release skin benefit or deodorizing salt, a hydrophilic moisturizing polymer and surfactants is described. The method imparts benefits or deodorizing agents to the skin or hair and maintains effective levels for an extended period.
    Type: Grant
    Filed: January 18, 2012
    Date of Patent: September 16, 2014
    Assignee: Nevada Naturals Inc.
    Inventors: Anthony E. Winston, Richard F. Stockel, Anthony Joseph Sawyer
  • Publication number: 20140242148
    Abstract: The invention provides methods and materials for decontamination of surfaces and fabrics, such as non-woven fabrics, that are contaminated with infestations of microorganisms such as bacteria. Biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group can be used to decontaminate infested surfaces in the presence of oxygen and, optionally, illumination. Fibers incorporating biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group, wherein the oligomer is physically associated with or covalently bonded to, or both, the fiber-forming polymer can be used to form non-woven mats. Biocidal non-woven mats prepared by methods of the invention, incorporating the biocidal oligomers, can be used to suppress bacterial growth in wound and surgical dressings and personal hygiene products.
    Type: Application
    Filed: August 3, 2012
    Publication date: August 28, 2014
    Applicant: University of Florida Research Foundation, Inc.
    Inventors: David G. Whitten, Kirk S. Schanze, Eunkyung Ji, Dimitri Dascier, Anand Parthasarathy, Thomas S. Corbitt, Kirsten Cicotte, Elizabeth LeBleu Dirk, Xuzhi Zhu
  • Publication number: 20140199249
    Abstract: The invention relates to the field of depositing agents on surfaces using highly volatile silicone solvents. Particularly, the invention relates to novel compositions useful for depositing agents on skin and other surfaces.
    Type: Application
    Filed: December 12, 2013
    Publication date: July 17, 2014
    Applicant: THOMPSON COOPER LABORATORIES, LLC
    Inventors: Eugene R. Cooper, Eric R. Thompson
  • Patent number: 8766005
    Abstract: The invention relates to a process for producing pharmaceutically acceptable salts of fingolimod (I), comprising the step of reacting N-[1,1-bis hydroxymethyl-3-(4-octyl phenyl)-propyl]-acylamide (II) with an acidic compound. Furthermore, the invention provides different pharmaceutically acceptable salts of fingolimod and a polymorphic form of fingolimod hydrochloride.
    Type: Grant
    Filed: July 23, 2010
    Date of Patent: July 1, 2014
    Assignee: Ratiopharm GmbH
    Inventors: Ramesh Matioram Gidwani, Channaveerayya Hiremath
  • Publication number: 20140178308
    Abstract: The present invention concerns a method for inducing an increase in the intraocular pressure in an animal, said method comprising ocular administration of a solution comprising benzalkonium chloride (BAK). The present invention further relates to an animal having ocular hypertension, said animal being obtained by the method according to the invention. Said animal provides a convenient animal model for better understanding of the patho-physiological mechanisms involved in ocular hypertension and glaucoma. The present invention also relates to the use of said animal for screening a compound for therapeutic use against ocular hypertension or glaucoma, and/or for assessing potential side-effects of treatment of ocular hypertension and glaucoma.
    Type: Application
    Filed: July 27, 2012
    Publication date: June 26, 2014
    Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: William Rostene, Christophe Baudouin, David Godefroy, Alexandre Denoyer
  • Publication number: 20140171513
    Abstract: Foaming formulations including a quaternary ammonium compound and a foam stabilizer are disclosed. These foaming formulations are useful as leave-on liquid hand and surface sanitizers. The foaming formulations provide improved aesthetic properties and foaming appearance, while maintaining high antimicrobial capacity.
    Type: Application
    Filed: December 17, 2012
    Publication date: June 19, 2014
    Applicant: KIMBERLY-CLARK WORLDWIDE, INC.
    Inventors: Jeffery Richard Seidling, Corey Thomas Cunningham
  • Publication number: 20140162969
    Abstract: There is provided a new use of microspheres comprising a water-insoluble, water-swellable polymer which is anionically charged at pH7, and electrostatically associated with the polymer, in releasable form, a cationically charged chemotherapeutic agent, in the manufacture of a composition for use in the treatment of a brain tumour, wherein in the treatment the composition is introduced into the brain and the chemotherapeutic agent is released from the microspheres, wherein the microspheres, when equilibrated in water at 37° C., comprise at least 40 wt % water based on weight of polymer plus water. Compositions comprising the microspheres and methods for the treatment of brain tumours are also provided.
    Type: Application
    Filed: February 14, 2014
    Publication date: June 12, 2014
    Applicant: BIOCOMPATIBLES UK LIMITED
    Inventors: Andrew Lennard LEWIS, Yiqing TANG, Peter William STRATFORD
  • Publication number: 20140163114
    Abstract: The present invention relates to substantially pure metabolites of irara-clomiphene. The invention is also directed to pharmaceutical compositions comprising these metabolites and their use in treating disorders including secondary hypogonadism, type 2 diabetes, elevated cholesterol, elevated triglycerides, wasting, lipodystrophy, female and male infertility, benign prostate hypertrophy, prostate cancer, breast cancer, ovarian cancer and endometrial cancer.
    Type: Application
    Filed: August 3, 2012
    Publication date: June 12, 2014
    Applicant: REPROS THERAPEUTICS INC.
    Inventors: Joseph S. Podolski, Ronald D. Wiehle
  • Publication number: 20140148487
    Abstract: The present invention is directed to compositions useful for antimicrobial applications. These compositions comprise amphiphilic compounds.
    Type: Application
    Filed: October 20, 2011
    Publication date: May 29, 2014
    Applicant: James Madison Innovations, Inc,
    Inventors: Kevin P. Minbiole, Kevin l Caren, Kyle n Seifert
  • Publication number: 20140113009
    Abstract: According to aspects of the present disclosure, a kit for transepithelial delivery of a cross-linking agent to a cornea includes a first vessel containing an initial formulation that includes a cross-linking agent and a first active ingredient configured to open corneal epithelial tight junctions when applied to a cornea and one or more second vessels each containing a respective secondary formulation that includes the cross-linking agent for application to the cornea after the initial formulation is applied to the cornea.
    Type: Application
    Filed: October 24, 2013
    Publication date: April 24, 2014
    Applicant: Avedro, Inc.
    Inventors: David Muller, Stephen M. Blinn, Robert Broderick
  • Publication number: 20140100288
    Abstract: Provided are largely aqueous topical antimicrobial cleaning composition which provides an antimicrobial benefit, as well as methods for their production and methods for their use. The compositions comprise at least two different cationic surfactants which provide a primary antimicrobial benefit, and as a predominant further surfactant an amine oxide surfactant. The composition are at an acidic pH and are highly effective in providing an antimicrobial benefit to topical surfaces, e.g, epidermis and hair.
    Type: Application
    Filed: June 18, 2012
    Publication date: April 10, 2014
    Applicant: RECKITT & COLMAN (OVERSEAS) LIMITED
    Inventor: Sarah DeSzalay
  • Publication number: 20140099357
    Abstract: Compositions, solid polymeric compositions, and/or articles of manufacture are provided that can include a polymer matrix having a plurality of ion-exchange particles distributed therein. Products by process are provided that can include prior to solidifying the polymeric precursors, blending the precursors with ion-exchange particles to form a mixture, and solidifying the mixture to form a solid polymeric composition product. Solid polymeric composition production methods are also provided that can include providing a plurality of ion-exchange particles, prior to solidifying the polymeric precursors, blending the precursors with the ion-exchange particles to form a mixture, and solidifying the mixture to form a solid polymeric composition. Article of manufacture production methods are provided that can include incorporating a solid polymeric composition into an article of manufacture, the solid polymeric composition including a polymer matrix and a plurality of ion-exchange particles distributed therein.
    Type: Application
    Filed: December 12, 2013
    Publication date: April 10, 2014
    Inventors: David J. Vachon, Nathan Knapp
  • Patent number: 8691839
    Abstract: The present application relates generally to amino tetraline derivative compounds and methods of use, specifically, embodiments including compounds of formula (I) described herein, pharmaceutically acceptable salts and solvates. More specifically, this application relates to amino tetraline derivative compounds and uses of such compounds producing medicaments for the treatment of various disease and conditions including movement disorders and disorders of the central nervous system.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: April 8, 2014
    Inventors: Peter Gmeiner, Miriam Ruberg, Harald Huebner
  • Patent number: 8637490
    Abstract: Described herein are compounds that may be selectively activated to produce active anti-cancer agents in tumor cells. Also disclosed are pharmaceutical compositions comprising the compounds, and methods of treating cancer using the compounds.
    Type: Grant
    Filed: July 1, 2012
    Date of Patent: January 28, 2014
    Assignee: UWM Research Foundation, Inc.
    Inventors: Xiaohua Peng, Yunyan Kuang, Sheng Cao, Wenbing Chen, Yibin Wang
  • Publication number: 20140024688
    Abstract: The present technology relates to biocidal compositions and methods that contain and utilize at least one biocidal agent and at least one potentiator system wherein the resultant combination has an enhanced biocidal efficacy. The present technology also discloses a rapid screening assay for determining biocidal compositions with enhanced efficacy, e.g., a microbial contact kill time of 5 minutes or less. Further, the present technology provides a method of determining biocidally effective concentrations of biocidal compositions comprising at least one biocidal agent and at least one potentiator system.
    Type: Application
    Filed: September 20, 2013
    Publication date: January 23, 2014
    Applicant: STEPAN COMPANY
    Inventors: Molly Ryan Callahan, David Shelton
  • Patent number: 8629135
    Abstract: A class of compounds useful in pharmaceutical compositions and methods for treating or preventing cancer is described. The compounds' ability to inhibit RET kinase is quantified, i.e., their respective RET IC50 and EC50 values are described. One such compound, known as cyclobenzaprine and herein as SW-01, has been identified as RET-specific with an IC50 of 300 nM. SW-01 inhibits RET autophosphorylation and blocks the growth and transformation of thyroid cancer cell lines. It has been further tested in pancreatic cancer, breast cancer, and SCLC cell lines. The compounds show utility for inhibition of survival and proliferation of tumor cells.
    Type: Grant
    Filed: July 14, 2009
    Date of Patent: January 14, 2014
    Assignee: Queen's University at Kingston
    Inventors: Taranjit S. Gujral, Lois M. Mulligan, Vinay K. Singh
  • Patent number: 8618175
    Abstract: Ultrasound medical gel composition, the compositions comprising: (a) a gelling agent comprising etherified hydroxyethylcellulose; (b) an antimicrobial agent, specifically the quaternary ammonium compound benzalkonium chloride; (c) a solvent, 1,3-propanediol being preferred; and (d) water.
    Type: Grant
    Filed: July 18, 2011
    Date of Patent: December 31, 2013
    Assignee: Brussels Ventures Corp.
    Inventor: Thomas Heinar
  • Publication number: 20130337019
    Abstract: Compositions containing quaternary compounds in which the nitrogen atom is substituted by at least one alkyl group having at least 12 carbon atoms, and the composition includes at least 20% in weight by weight of the total composition, of ammonium halides in which the nitrogen atom is substituted by at least one alkyl group having at least 14 carbon atoms and more than 5%, preferably more than 7% in weight by weight of the total composition, of ammonium halides in which the nitrogen atom is substituted by at least one alkyl group having at least 16 carbon atoms. Also, ophthalmic oil-in-water emulsions containing such compositions, the ophthalmic emulsions being useful for eye care or for the treatment of eye conditions.
    Type: Application
    Filed: August 2, 2013
    Publication date: December 19, 2013
    Applicant: NOVAGALI PHARMA SA
    Inventors: LAURA RABINOVICH-GUILATT, GREGORY LAMBERT, FREDERIC LALLEMAND, BETTY PHILIPS
  • Publication number: 20130330387
    Abstract: Antimicrobial lubricant compositions are disclosed. The antimicrobial lubricant compositions are particularly useful in providing antimicrobial capability to a wide-range of medical devices. The compositions include an oil lubricant. Representative lubricants may include polydimethyl siloxane, trifluoropropyl copolymer polysiloxane, and a copolymer of dimethylsiloxane and trifluoropropylmethylsiloxane. The compositions include rheology modifiers as necessary. The compositions also include antimicrobial agents, which may be selected from a wide array of agents. Representative antimicrobial agents include of aldehydes, anilides, biguanides, bis-phenols, quaternary ammonium compounds, cetyl pyridium chloride, cetrimide, alexidine, chlorhexidine diacetate, benzalkonium chloride, and o-phthalaldehyde.
    Type: Application
    Filed: April 22, 2013
    Publication date: December 12, 2013
    Applicant: Becton, Dickinson and Company
    Inventor: Becton, Dickinson and Company
  • Patent number: 8586603
    Abstract: The present application relates to compounds of formula (I): and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of such compounds in producing medicaments for the treatment of various diseases and conditions, such as of the central nervous system.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: November 19, 2013
    Inventors: Peter Gmeiner, Miriam Ruberg, Harald Hüebner