Benzene Ring Containing Patents (Class 514/643)
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Patent number: 6858651Abstract: The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.Type: GrantFiled: August 9, 2001Date of Patent: February 22, 2005Assignee: Hoffmann-La Roche Inc.Inventors: Jean Ackermann, Johannes Aebi, Denise Blum, Alexander Chucholowski, Henrietta Dehmlow, Hans-Peter Maerki, Olivier Morand, Rene Trussardi, Elisabeth von der Mark, Sabine Wallbaum, Thomas Weller
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Patent number: 6846846Abstract: Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin.Type: GrantFiled: October 23, 2001Date of Patent: January 25, 2005Assignee: The Trustees of Columbia University in the City of New YorkInventors: Shanta Modak, Trupti A. Gaonkar, Lester Sampath
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Patent number: 6835754Abstract: 3,4,5-trisubstituted aryl nitrone compounds having the formula: where R1-R4 are as defined in the specification are useful as therapeutics for neuropathic pain conditions in mammals.Type: GrantFiled: January 8, 2002Date of Patent: December 28, 2004Assignee: Renovis, Inc.Inventors: L. David Waterbury, Paul L. Wood, M. Amin Khan, Ravindra B. Upasani
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Publication number: 20040220224Abstract: The invention features a method of treating irritable bowel syndrome (IBS) by administering quarternary ammonium compounds of formulae I-V, described herein.Type: ApplicationFiled: April 13, 2004Publication date: November 4, 2004Applicant: Pfizer IncInventors: Ivan Michael Richards, Karen Patrice Kolbasa
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Publication number: 20040219227Abstract: Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin. Hydroalcoholic gel composition containing alcohol, water, hydrogel, and emollient or emulsifier, wherein the composition has a viscosity of below 2000 centipoises at between 20 and 40° C.Type: ApplicationFiled: February 25, 2004Publication date: November 4, 2004Inventors: Shanta Modak, Trupti A. Gaonkar
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Publication number: 20040214867Abstract: In one aspect, the present invention concerns the use of certain quaternary ammonium compounds as active ingredient in the manufacture of a medicament for use in the treatment and/or prevention of cough in warm-blooded animals, including humans, such as compounds of the following formula (I): Y-J-E An− wherein J is independently selected from a group represented by one of formulae (II), (III) and (IV).Type: ApplicationFiled: February 14, 2003Publication date: October 28, 2004Inventors: Lewis Siu Leung Choi, Gregory N Beatch, Clive Page
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Publication number: 20040209916Abstract: The invention is directed to methods of treating asthma, COPD, allergic rhinitis, and infectious rhinitis by administering a first pharmaceutical agent including one or more compounds selected from the quarternary ammonium compounds of formulae I-V and a second pharmaceutical agent including one or more pharmaceutical agents selected from Adenosine A2a Receptor Agonists, D2-Dopamine Receptor Agonists, Phosphodiesterase Inhibitors (PDE's), corticosteroids, norepinephrine reuptake inhibitors, 4-hydroxy-7-[2-[2-[3-[2-phenylethoxy]-propylsulphonyl]ethylamino]ethyl]-1,3-benzothiazol-2(3H)-one, and pharmaceutically acceptable salts thereof, and non-quarternized antimuscarinic compounds.Type: ApplicationFiled: April 13, 2004Publication date: October 21, 2004Applicant: Pfizer IncInventors: Ivan Michael Richards, Robert Everett Manning
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Publication number: 20040186183Abstract: Compositions, methods and systems for treating disordered epithelial tissues, such as is caused by pathogens and/or by toxins produced thereby. The invention relates to the use of an anti-infective and/or antimicrobial active agent in a carrier, with vigorous agitation of the disordered epithelial tissue for topical treatment thereof under such conditions sufficient to achieve clinically discernable improvement of the disordered epithelial tissue. The preferred anti-infective and/or antimicrobial active agent comprises an organohalide, such as a quaternary ammonium halide compound, preferably benzalkonium chloride. The inventive compositions and methods may employ the use of an applicator adapted for use in promoting the penetration of the treatment composition and/or the vigorous agitation of the disordered tissue.Type: ApplicationFiled: April 1, 2004Publication date: September 23, 2004Inventor: B. Ron Johnson
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Patent number: 6794543Abstract: The invention provides a process for preparing arylpoly(oxalkyl)benzyl-dimethylammonium derivatives of the formula (1) which comprises reacting compounds of the formulae (2) and (3) where X=Br, Cl, R—SO3 with R=alkyl, alkylaryl R1=H, C1- to C16-alkyl or O—C1- to O—C16-alkyl in the ortho, meta or para position, R2=H, C1- to C4-alkyl or O—C1- to O—C4-alkyl, R3=H, C1- to C16-alkyl or O—C1- to O—C16-alkyl in the ortho, meta or para position, and n=1, 2, 3 or 4, at temperatures of from 60 to 160° C. in a solvent under the autogenous pressure.Type: GrantFiled: November 14, 2002Date of Patent: September 21, 2004Assignee: Clariant GmbHInventors: Klaus Raab, Gerhard Crass, Rudolf Aigner
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Patent number: 6787164Abstract: An improved medicinal composition includes an effective amount of a pain relieving and anti-inflammatory pharmaceutical and an effective amount of a nutraceutical in a pharmaceutically acceptable base. At least one of the pharmaceutical and the nutraceutical treats a condition caused by an immune response to a virus, a microorganism, or an atmospheric pollutant or allergen. The pain relieving and anti-inflammatory pharmaceutical is preferably acetaminophen or a non-steroidal anti-inflammatory drug (NSAID). The medicinal composition may additionally include a pharmaceutical decongestant or antihistamine. The nutraceutical is preferably an immune booster, an anti-oxidant, a liver protectant, or a combination thereof. Methods of using these compositions to treat conditions caused by an immune response are also disclosed.Type: GrantFiled: January 5, 2001Date of Patent: September 7, 2004Assignee: Bioselect Innovations, Inc.Inventors: Daniel Gelber, Richard Kleinberger
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Publication number: 20040127464Abstract: The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation, and in particular inflammatory diseases associated with unwanted cellular proliferation. The active compounds are substituted triaryl methane compounds or analogues thereof where one or more of the aryl groups is replaced with a heteroaryl, cycloalkyl or heterocycloalkyl group and/or the tertiary carbon atom is replaced with a different atom such as Si, Ge, N or P. the compounds inhibit mammalian cell proliferation, inhibit the Gardos channel of erythrocytes, reduce sickle erythrocyte dehydration and/or delay the occurrence of erythrocyte sickling or deformation.Type: ApplicationFiled: June 3, 2003Publication date: July 1, 2004Inventors: Carlo Brugnara, Jose Halperin, Emile M. Bellot, Mark Froimowitz, Richard John Lombardy, John J. Clifford, Ying-Duo Gao, Reem M. Haidar, Eugene W. Kelleher, Falguni M. Kher, Adel M. Moussa, Yesh P. Sachdeva, Minghua Sun, Heather N. Taft
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Publication number: 20040091448Abstract: The invention provides aqueous disinfecting (germicidal) dip compositions comprising opacifying complexes formed by the reaction of cationic organic quaternary ammonium compounds (“quats”)and anionic organic sulfonates. The compositions are particularly useful as dairy cow teat dips. Complexes formed by the reaction of quats and organic sulfonates provide turbidity and opacity to these aqueous germicidal dip compositions. Such turbidity and opacity serve to enhance the visibility of the compositions, e.g., when applied to an animal's teat.Type: ApplicationFiled: November 13, 2002Publication date: May 13, 2004Inventor: Robert D. Kross
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Publication number: 20040067938Abstract: Novel quaternary amine containing compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.Type: ApplicationFiled: November 3, 2003Publication date: April 8, 2004Inventors: Penglie Zhang, Robert M. Scarborough, Bing-Yan Zhu
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Publication number: 20040058878Abstract: Germicidal compositions with enhanced activity towards killing microbiological spores and vetgetative cells comprising certain quaternary ammonium compounds (QACs), phenolic compounds, monohydric alcohols, hydrogen peroxide, iodine, triclocarban, triclosan or combinations thereof with one or more spore coat opening agents. The invention also provides for the application of the germicidal compositions to animate and inanimate surfaces to help kill germs and protect against the risk of infection from bacteria, molds, yeasts, fungi, viruses, and microbiological spores.Type: ApplicationFiled: January 16, 2003Publication date: March 25, 2004Inventor: Edward B. Walker
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Patent number: 6706290Abstract: Nanobacteria contribute to pathological calcification in the human and animal body, including diseases such as kidney stones, salivary gland stones, dental pulp stones and atherosclerosis. The present invention provides methods for sterilizing articles contaminated with nanobacteria. The present invention also provides methods of treating patients infected with nanobacteria. In particular, the present invention provides a method for preventing the recurrence of kidney stones in a patient that has suffered from kidney stones, comprising administration of an antibiotic, a bisphosphonate, or a calcium chelator, either alone or in combination, in an amount effective to inhibit or prevent the growth and development of nanobacteria.Type: GrantFiled: July 2, 1999Date of Patent: March 16, 2004Inventors: Olvai E. Kajander, Neva Ciftcioglu
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Publication number: 20040019043Abstract: The current invention provides novel thiomolybdate derivatives, methods of making novel thiomolybdate derivatives, pharmaceutical compositions of novel thiomolybdate derivatives, methods of using novel thiomolybdate derivatives to treat diseases associated with aberrant vascularization and methods of using pharmaceutical compositions of thiomolybdate derivatives to treat diseases associated with aberrant vascularization.Type: ApplicationFiled: July 23, 2002Publication date: January 29, 2004Inventors: Dimitri Coucouvanis, Robert J. Ternansky, Patricia L. Gladstone, Amy L. Allan, Melissa L.P. Price, Sean M. O'Hare
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Publication number: 20040019087Abstract: The current invention provides novel thiomolybdate derivatives, methods of making novel thiomolybdate derivatives, pharmaceutical compositions of novel thiomolybdate derivatives, methods of using novel thiomolybdate derivatives to treat diseases associated with aberrant vascularization, copper metabolism disorders, neurodegenerative disorders, obesity or NF-&kgr;B dysregulation and methods of using pharmaceutical compositions of thiomolybdate derivatives to treat diseases associated with aberrant vascularization, copper metabolism disorders, neurodegenerative disorders, obesity or NF-&kgr;B dysregulation.Type: ApplicationFiled: May 28, 2003Publication date: January 29, 2004Inventors: Robert J. Ternansky, Andrew Mazar, Patricia L. Gladstone, Dimitri Coucouvanis, Amy L. Allan, Sean M. O'Hare, Melissa L.P. Price, Steven Robert Pirie-Shepherd, Fernando Donate
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Patent number: 6680345Abstract: The present invention relates to new substituted salicylic acid salts of salmeterol, processes for preparing them and their useType: GrantFiled: September 12, 2002Date of Patent: January 20, 2004Assignee: Boehringer Ingelheim Pharma KGInventors: Guenter Linz, Rainer Soyka, André Steiner
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Patent number: 6664296Abstract: This galenical formulation which comprises first an outer envelope including gelatin and secondly a non-aqueous liquid or semi-liquid internal phase containing an active principle in solution is characterized in that the active principle is constituted by a spermicide and in that the internal phase includes, in addition to the active principle: a major proportion of a lipophilic agent compatible with the rubber latex of a condom; in minor proportion at least one hydrodispersible agent; at least one bioadhesion agent; and at least one agent for gelling the lipophilic agent. This galenical formulation for vaginal use provides the known advantages of the soft capsule, having properties that are simultaneously spermicidal, antiseptic, and lubricating, and in addition it is reliably compatible with condoms, without any risk of damaging the rubber latex thereof.Type: GrantFiled: August 19, 1997Date of Patent: December 16, 2003Assignee: Laboratoire Innothera societe AnonymeInventor: Catherine Meignant
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Publication number: 20030199507Abstract: Disclosed are pharmaceutical compositions comprising brimondine and timolol for topical ophthalmic delivery and a method of treatment comprising administering said composition when indicated for glaucoma and associated conditions such as elevated intraocular pressure in the eyes of humans.Type: ApplicationFiled: February 3, 2003Publication date: October 23, 2003Inventors: Chin-Ming Chang, Gary J. Beck, Cynthia C. Pratt, Amy L. Batoosingh
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Publication number: 20030199509Abstract: Disclosed are pharmaceutical compositions comprising brimondine and timolol for topical ophthalmic delivery and a method of treatment comprising administering said composition when indicated for glaucoma and associated conditions such as elevated intraocular pressure in the eyes of humans.Type: ApplicationFiled: April 19, 2002Publication date: October 23, 2003Inventors: Chin-Ming Chang, Gary J. Beck, Cynthia C. Pratt, Amy L. Batoosingh
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Patent number: 6632805Abstract: A method of dyeing and treating a substrate using a water-stabilized organosilane. A method of antimicrobially treating a food article. A method of antimicrobially coating a fluid container. A method of antimicrobially coating a latex medical article.Type: GrantFiled: May 7, 1996Date of Patent: October 14, 2003Assignee: Emory UniversityInventors: Lanny S. Liebeskind, Gary D. Allred
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Publication number: 20030181489Abstract: In one aspect, the present invention concerns the use of certain quaternary ammonium compounds as active ingredient in the manufacture of a medicament for use in the treatment and/or prevention of cough in warm-blooded animals, including humans, such as compounds of formula Y—J—E An− (I), wherein J is independently selected from a group represented by one of formulae (II), (III) and (IV).Type: ApplicationFiled: February 14, 2003Publication date: September 25, 2003Inventors: Lewis Siu Leung Choi, Gregory N Beatch, Clive Page
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Patent number: 6624202Abstract: The present invention is directed to hydrazino compounds that function as inhibitors of copper-containing amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-1 (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatoses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The compounds have the general formula: or a pharmaceutically acceptable solvate, hydrate, or salt thereof, wherein R1 to R8 and X are as defined herein.Type: GrantFiled: July 5, 2001Date of Patent: September 23, 2003Assignee: Biotie Therapies Corp.Inventors: David John Smith, Markku Jalkanen, Ferenc Fülöp, László Lázár, Zsolt Szakonyi, Gábor Bernáth
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Publication number: 20030166732Abstract: The invention relates to the use of ambroxol and the pharmacologically acceptable salts thereof for preparing a pharmaceutical composition for the treatment of painful conditions in the oral and pharyngeal cavity.Type: ApplicationFiled: February 27, 2003Publication date: September 4, 2003Applicant: Boehringer Ingelheim Pharma GmbH & Co. KGInventors: Anke Esperester, Uwe Pschorn, Jean-Michel Vix
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Patent number: 6613340Abstract: Substantive UV absorbing organic-soluble quaternary salts of cinnamidoalkylamine are described. Hair, skin and fabric care compositions containing the compounds of formula I. wherein R1 is a substituent, selected from H, halo, —OH, —NH2, —NO2, —OCH3, —N(CH3)2, alkyl groups containing from 1 to 6 carbon atoms, alkoxy groups containing from 1 to 6 carbon atoms, alkylamino or N,N-dialkylamino groups containing from 1 to 6 carbon atoms; R2 is selected from hydrogen, alkyl group containing from 1 to 12 carbon atoms; R3 and R4 are independently selected from benzyl, alkyl group containing from 1 to 12 carbon atoms; n is an integer from 1 to 6; R5 is selected from an alkyl group containing from 8 to 22 carbon atoms; alkenyl groups containing from 8 to 22 carbon atoms; R7 is selected from bromo, chloro, nitro, methyl and ethyl groups.Type: GrantFiled: July 31, 2001Date of Patent: September 2, 2003Assignee: Galaxy Surfactants Ltd.Inventors: Nirmal Madhukar Koshti, Arun Harchandra Jawale, Bharat Bhikaji Parab, Shubhangi Dattaram Naik, Manasi Dattatraya Moghe, Tanaji Shamrao Jadhav, Subhash Shivling Nashte
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Publication number: 20030158176Abstract: Novel quaternary ammonium compounds of the formula 1Type: ApplicationFiled: October 25, 2002Publication date: August 21, 2003Inventors: Ivan Richards, Sue K. Cammarata, Craig D. Wegner, Michael Hawley, Mark Peter Warchol, Mark Kontny, Walter Morozowich, Karen Patrice Kolbasa, Malcolm Wilson Moon, Dominique Bonafoux, Sergey Gregory Wolfson, Patrick James Lennon
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Publication number: 20030157193Abstract: A polymeric composition having antimicrobial properties and a process for rendering the surface of a substrate antimicrobial are disclosed. The composition comprises a crosslinked chemical combination of (i) a polymer having amino group-containing side chains along a backbone forming the polymer, (ii) an antimicrobial agent selected from quaternary ammonium compounds, gentian violet compounds, substituted or unsubstituted phenols, biguanide compounds, iodine compounds, and mixtures thereof, and (iii) a crosslinking agent containing functional groups capable of reacting with the amino groups.Type: ApplicationFiled: February 5, 2002Publication date: August 21, 2003Inventors: William F. McDonald, Zhi-Heng Huang, Stacy C. Wright
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Patent number: 6599944Abstract: Ophthalmic composition with prolonged residence time on the eye, in particular in the form of a gel which can be administered as drops, of an ointment or the like, containing a free-flowing vehicle with increased viscosity and a preservative, and, where appropriate, one or more active ingredients and conventional additives such as tonicity agents, substances to adjust the pH etc. The preservative is essentially formed according to the invention by a benzyllauryldimethylammonium salt. The invention furthermore relates to the use of a benzyllauryldimethylammonium salt as preservative for producing ophthalmic compositions intended for repeated use over lengthy periods and/or formulated for a lengthy residence time on the eye after each use, whereby irritation and/or damage to the tissue of the eye are avoided.Type: GrantFiled: May 19, 2000Date of Patent: July 29, 2003Assignee: Bausch & Lomb IncorporatedInventors: Gunther Bellmann, Gudrun Claus-Herz
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Publication number: 20030138385Abstract: A method of preventing mucositis of mucosal tissues in patients is disclosed which is based on contacting the affected area with an amount of composition which comprises triclosan in amounts which are effective to prevent the symptoms of mucositis.Type: ApplicationFiled: January 16, 2003Publication date: July 24, 2003Inventor: Barry M. Libin
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Patent number: 6596708Abstract: A composition for the treatment and prevention of endothelial dysfunction comprising a therapeutically effective amount of anti-inflammatory agents comprising; acetylsalicylic acid, an amino sugar and a zinc compound.Type: GrantFiled: September 7, 2001Date of Patent: July 22, 2003Assignee: Advanced Medical InstrumentsInventor: Edward J. Petrus
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Patent number: 6593366Abstract: A method for treating a microbial infection in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising an amino group or an ammonium group attached to the polymer backbone via an aliphatic spacer group. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.Type: GrantFiled: February 21, 2002Date of Patent: July 15, 2003Assignee: GelTex Pharmaceuticals, Inc.Inventors: W. Harry Mandeville, III, Thomas X. Neenan, Stephen Randall Holmes-Farley
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Publication number: 20030114533Abstract: The invention provides a process for preparing arylpoly(oxalkyl)benzyl-dimethylammonium derivatives of the formula (1) 1Type: ApplicationFiled: November 14, 2002Publication date: June 19, 2003Inventors: Klaus Raab, Gerhard Crass, Rudolf Aigner
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Patent number: 6579622Abstract: A wood preservative composition which comprises water soluble acidic copper salts plus water soluble fatty amine salts in a weight ratio of from 0.1 to 10 parts water soluble fatty amine salt for each part of water soluble acidic copper salt. Methods for protecting wood from termites, decay, and mildew, and for reducing the ferrous metal corrosion properties of water soluble copper salts by using the disclosed composition are provided.Type: GrantFiled: August 31, 2001Date of Patent: June 17, 2003Inventor: Michael Howard West
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Publication number: 20030096805Abstract: Methods and compositions of antidepressants and analogs thereof for inducing local long-lasting anesthesia and analgesia are provided. The methods and compositions are useful for alleviating acute and chronic pain, particularly useful for treating a localized pain.Type: ApplicationFiled: April 4, 2002Publication date: May 22, 2003Inventors: Ging Kuo Wang, Peter Gerner, Donald K. Verrecchia
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Patent number: 6562865Abstract: This invention relates to a pharmaceutical composition comprising a combination of a tramadol material and an anticonvulsant drug and to the pharmacological use of the composition in treating conditions of pain and neurologic or psychiatric disorders. The composition produces a combination product having improved properties, requiring less of each ingredient and producing a synergistic effect.Type: GrantFiled: August 9, 2000Date of Patent: May 13, 2003Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Ellen E. Codd, Rebecca P. Martinez, Kathryn E. Rogers
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Publication number: 20030086880Abstract: A composition for forming an antimicrobial artificial nail, a method for preparing the same, and a method for treating a microbial infection of a nail plate are provided. The composition comprises a binder component; a filler component which polymerizes to form an acrylic matrix subsequent to contact with the binder component; and an antimicrobial agent available for diffusion from the acrylic matrix.Type: ApplicationFiled: September 17, 2002Publication date: May 8, 2003Inventors: David Dyer, Kenneth B. Gerenraich
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Patent number: 6559186Abstract: Sympathetically maintained pain is treated topically by administering to the site where sympathetically maintained pain is present an &agr;-1-adrenergic antagonist, &agr;-2-adrenergic agonist, or other drug that depletes or blocks synthesis of sympathetic norepinephrine, known collectively as sympatholytic agents. Chemical formulas for several sympatholytic agents are given.Type: GrantFiled: August 5, 1994Date of Patent: May 6, 2003Assignee: Arc 1, Inc.Inventor: James N. Campbell
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Patent number: 6538035Abstract: The present invention is a method of treating an mammal selected from the group consisting of humans and horses who has asthma, COPD or allergic rhinitis and is in need of such treatment by inhaling an anti-asthma, anti-COPD anti-allergic rhinitis effective amount, respectively, of a compound selected from the group consisting of tolterodine hydroxytolterodine and 2-(diisopropylamino)ethyl-1-phenylcyclopentanecarboxylate and pharmaceutically acceptable salts thereof.Type: GrantFiled: October 23, 2001Date of Patent: March 25, 2003Assignee: Pharmacia & Upjohn CompanyInventors: Per-Goran Gillberg, Staffan Sundquist, Sue K. Cammarata
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Publication number: 20030049272Abstract: A pharmaceutical composition which reduces or eliminates the drug abuse potential of central nervous system stimulant comprising: (a) a central nervous system stimulant selected from the group consisting of methylphenidate, amphetamine, methamphetamine, and combinations thereof; and (b) a mucous membrane irritant selected from the group consisting of organic and inorganic acid, salt, ketone, nitrite, sulfide, bisulfate, persulfate, glycerophosphate, hypophosphate, borate, titanate, amino acid, peptide, and combinations thereof, wherein the mucous membrane irritant produces irritation when contacted with the skin or mucous membrane.Type: ApplicationFiled: August 30, 2001Publication date: March 13, 2003Inventors: Yatindra Joshi, Russell Somma
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Patent number: 6525071Abstract: An antimicrobial composition containing between about 0.0005 and about 1 weight percent of an antimicrobial agent; between about 0.05 and about 5 weight percent of a keratolytic agent; between about 0.001 and about 10 weight percent of a surfactant; and at least about 60 weight percent water.Type: GrantFiled: March 20, 2001Date of Patent: February 25, 2003Assignee: MCJ, Inc.Inventor: David L. Dyer
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Patent number: 6518313Abstract: Solid sanitizing compositions have advantages over corresponding liquids and powders. A solid sanitizing product can be contained within a plastic bottle with a label indicating that the contents have antimicrobial or deodorizing properties containing a non-flowable solid composition having greater than about 0.02 percent by weight antimicrobial compounds. The preferred solid sanitizing compositions consist essentially of an antimicrobial compound selected from the group consisting of quaternary ammonium salts, fatty amines and diamines, chlorhexidine gluconate, phenol, derivatives of phenol, parachloro metaxylenol and mixtures thereof, and between 0 and 99.98 percent by weight of a cleaning composition. The solid sanitizing compositions can be effectively used with solid dispensers. The solid dispensers have a bowl with a drain at the bottom and an upward pointing spray nozzle.Type: GrantFiled: February 8, 2001Date of Patent: February 11, 2003Assignee: Sunburst Chemicals, Inc.Inventor: William H. Scepanski
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Publication number: 20030022941Abstract: Antibacterial compositions having enhanced antibacterial effectiveness are disclosed. The antibacterial compositions contain an antibacterial agent, an alkamine oxide, a nonionic and/or cationic cosurfactant, an optional polymeric thickener, and water.Type: ApplicationFiled: March 27, 2001Publication date: January 30, 2003Inventors: Timothy J. Taylor, Priscilla S. Fox, E. Phil Seitz, Michael D. Slayton
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Publication number: 20030013769Abstract: A compound of formula I: 1Type: ApplicationFiled: May 6, 2002Publication date: January 16, 2003Inventors: Ravindranath Mukkamala, Rajiv Manohar Banavali
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Patent number: 6503952Abstract: An antimicrobial composition comprising (i) between 0.025 and 2 percent of an antimicrobial agent selected from the group consisting of chlorhexidine free base, a chlorhexidine salt, polyhexamethylene biguanide, and alexidine; (ii) between 0.005 and 0.1 percent of a quaternary ammonium compound; and (iii) between 0.025 and 2 percent of a chlorinated phenol compound.Type: GrantFiled: January 11, 2001Date of Patent: January 7, 2003Assignee: The Trustees of Columbia University in the City of New YorkInventors: Shanta Modak, Lester Sampath, Lauserpina A. Caraos
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Publication number: 20030004216Abstract: A disinfectant composition containing more than 0.05% and less than 9.4% by volume of dimethyl benzyl lauryl ammonium bromide, substantially pure, substantially de-ionized, substantially bacteria free water if the pH of the water is between 5.0 and 6.8, a first stabilizer structured to adjust a pH level of the disinfectant composition to approximately 7, ammonium sulfate structured to increase a strength of the composition and a stabilizer structured to lower the pH level of the disinfectant composition back to approximately 7.Type: ApplicationFiled: August 26, 2002Publication date: January 2, 2003Inventor: Bernardo Birnbaum
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Publication number: 20030003095Abstract: Activated carbon, as well as compositions and kits comprising the same, are effective for preventing pregnancy and sexually transmitted diseases including HIV.Type: ApplicationFiled: August 8, 2002Publication date: January 2, 2003Applicant: The Procter & Gamble CompanyInventors: Richard Joseph Sunberg, Sheri Anne Hunt
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Patent number: 6500465Abstract: The present invention relates to a volatile, residue free peroxide antimicrobial composition, which can be applied as a penetrating and durable, fine aerosol, that has superior strength with respect to decontaminating buildings infected with bacteria, fungi, virus or fungal or bacterial spores. The present invention is also directed to a process for decontaminating large man made structures and the air contained in these.Type: GrantFiled: March 4, 2002Date of Patent: December 31, 2002Inventor: Alvin Ronlan
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Publication number: 20020198265Abstract: This invention provides a spermicidally and virucidally effective, vaginally applicable formulation, having the following approximate composition of essential ingredients:Type: ApplicationFiled: July 29, 2002Publication date: December 26, 2002Applicant: GEDA International Marketing Company Ltd.Inventors: George M. Livingston, David B. Thornburgh, Jeffrey Longmore
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Patent number: 6498234Abstract: The invention provides histidine kinase polypeptides and DNA (RNA) encoding histidine kinase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidine kinase polypeptides to screen for antibacterial compounds.Type: GrantFiled: March 14, 2000Date of Patent: December 24, 2002Assignees: SmithKline Beecham Corporation, SmithKline Beecham plcInventor: Nicola Gail Wallis