Carbon To Carbon Unsaturation Patents (Class 514/703)
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Publication number: 20120322891Abstract: Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided.Type: ApplicationFiled: March 14, 2012Publication date: December 20, 2012Applicant: UNIVERSITY OF WASHINGTONInventors: KRZYSZTOF PALCZEWSKI, DAVID A. SAPERSTEIN
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Publication number: 20120309848Abstract: The present invention relates to a method for preventing or treating dyslipidemia or fatty liver, comprising: administering to a mammalian subject in need thereof a therapeutically effective amount of a composition comprising nonenal. The present composition containing nonenal as an active ingredient is very effective in preventing or treating obesity, diabetes, dyslipidemia, fatty liver or insulin resistance syndrome (preferably, dyslipidemia or fatty liver, more preferably hyperlipidemia or fatty liver). The composition of the present invention useful as pharmaceuticals compositions or functional food compositions has therapeutic efficacies for obesity, diabetes, hyperlipidemia or fatty liver, and also induces significant decrease in fasting glucose level and blood insulin level to improve type 2 diabetes, insulin resistance and related metabolic disorders.Type: ApplicationFiled: May 30, 2012Publication date: December 6, 2012Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION YONSEI UNIVERSITYInventor: Tae Sun PARK
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Publication number: 20120258177Abstract: The present invention provides microcapsules comprising benzoyl peroxide and topical compositions comprising them, optionally along with other active ingredients, particularly for the treatment of acne.Type: ApplicationFiled: October 7, 2010Publication date: October 11, 2012Inventors: Danny Goldstein, Tal Sade, Yuri Yasman, Olga Privalova, Lior Benaltabet
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Patent number: 8278360Abstract: Provided are a behavior-disrupting agent of Argentine ants for controlling them or suppressing their reproduction is a safer and more effective manner, and the behavior-disrupting method of them. More specifically, a behavior-disrupting agent of Argentine ants comprising Z-9-hexadecenal, and a behavior-disrupting method of Argentine ants comprising a step of using the behavior-disrupting agent are provided based on the finding that the behavior of Argentine ants is disrupted by emission of Z-9-hexadecenal, which is a trail pheromone, into the atmosphere.Type: GrantFiled: February 23, 2005Date of Patent: October 2, 2012Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Sadahiro Tatsuki, Mamoru Terayama, Yasutoshi Tanaka, Takehiko Fukumoto
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Patent number: 8268294Abstract: The photostabilizing electronic excited state energy—particularly singlet state energy from retinoid compounds—has been found to be readily transferred to (accepted by) ?-cyanodiphenylacrylate compounds having an alkoxy radical in the four (para) position (hereinafter “alkoxycrylenes”) on one of the phenyl rings having the formula (I): wherein one of R1 and R2 is a straight or branched chain C1-C30 alkoxy radical, preferably C1-C8, more preferably methoxy, and the non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C30 alkyl radical, preferably C2-C20. The alkoxycrylene compounds of formula (I) significantly increase the photostability of retinoid compounds in a composition by at least 3-fold and as much as 10-fold or greater. The ability of the alkoxycrylene compounds to stabilize the retinoid compound is concentration dependent, with the amount of retinoid photostabilization increasing with the concentration of the alkoxycrylene compound.Type: GrantFiled: February 22, 2011Date of Patent: September 18, 2012Assignee: Hallstar Innovations Corp.Inventors: Craig A. Bonda, Anna Pavlovic, Jean Zhang
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Patent number: 8268895Abstract: The present invention concerns the use as perfuming ingredient, for instance to impart odor notes of the floral and/or green type, of a compound of formula 5 wherein R is an ortho, meta or para substituent of the phenyl, and represents a hydrogen atom or a C 1-2 alkyl or alkoxyl group; R 1 represents a hydrogen atom or a methyl or ethyl group; 10 R 2 represents a hydrogen atom or a C 1-3 alkyl group; and X represents a CHO, COOR 3, CH(OR 4) 2 or CN group, R 3 being a methyl or ethyl group, and R 4, taken seperately, being a methyl or ethyl group, or said R 4, taken together, a C 2-5 alkanediyl group; and at least one of said R, R 1 or R 2 represents a group containing at least one carbon atom.Type: GrantFiled: November 3, 2009Date of Patent: September 18, 2012Assignee: Firmenich SAInventor: Robert Moretti
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Patent number: 8263654Abstract: Compositions for the treatment of the skin. The compositions reduce and/or reverse the visible appearance of skin damage. In the preferred embodiment, the composition includes Retinyl Palmitate Polypeptide; Ascorbylmethylsilanol Pectinate; Tocopheryl Polypeptide; Cholecalciferol Polypeptide; and Niacinamide Polypeptide.Type: GrantFiled: October 1, 2010Date of Patent: September 11, 2012Inventor: Simon Erani
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Patent number: 8263051Abstract: The photostabilizing electronic excited state energy—particularly singlet state energy from resveratrol compounds—has been found to be readily transferred to (accepted by) ?-cyanodiphenylacrylate compounds having an alkoxy radical in the four (para) position (hereinafter “alkoxycrylenes”) on one of the phenyl rings having the formula (I): wherein one of R1 and R2 is a straight or branched chain C1-C30 alkoxy radical, preferably C1-C8, more preferably methoxy, and the non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C30 alkyl radical, preferably C2-C20. The alkoxycrylene compounds of formula (I) significantly increase the photostability of resveratrol compounds in a composition by at least 3-fold and as much as 10-fold or greater. The ability of the alkoxycrylene compounds to stabilize the resveratrol compound is concentration dependent, with the amount of resveratrol photostabilization increasing with the concentration of the alkoxycrylene compound.Type: GrantFiled: April 5, 2011Date of Patent: September 11, 2012Assignee: Hallstar Innovations Corp.Inventors: Craig A. Bonda, Anna Pavlovic, Jean Zhang
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Publication number: 20120225781Abstract: A method for controlling pests and weeds on or around plants, especially crop plants is disclosed. The method includes admixing 2-propenal or other related enal compounds to form an aqueous solution, and applying the aqueous solution to plants, plant seeds, weeds, or soil around the around the area in which the plants grow.Type: ApplicationFiled: April 18, 2012Publication date: September 6, 2012Applicant: AUBURN UNIVERSITYInventors: Rodrigo Rodriguez-Kabana, Elizabeth A. Guertal, Robert H. Walker, David H. Teem
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Patent number: 8226933Abstract: A skin care product comprising from about 0.001% to about 10% of a retinoid, in combination with 0.0001% to about 50% of a combination of retinoid boosters.Type: GrantFiled: April 29, 2011Date of Patent: July 24, 2012Assignee: Unilever Home & Personal Care, USA division of Conopco, Inc.Inventors: Stewart Paton Granger, Ian Richard Scott, Robert Mark Donovan, Susanne Teklits Iobst, Lisa Licameli
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Publication number: 20120148690Abstract: A novel skin barrier function recovery acceleration method and accelerator are provided. The present invention provides a skin barrier function recovery accelerator that comprises a TRPA1 agonist capable of activating TRPA1 in epidermal cells.Type: ApplicationFiled: December 10, 2010Publication date: June 14, 2012Inventors: Mitsuhiro Denda, Moe Tsutsumi, Sumiko Denda
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Publication number: 20120093952Abstract: The present invention relates to the use of essential oil compounds as histomonastats. An example of a essential oil compound of the invention is cinnamaldehyde.Type: ApplicationFiled: November 20, 2008Publication date: April 19, 2012Inventors: Marco Frehner, Riccardo Losa, Didier Archain
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Publication number: 20120087871Abstract: Methods for killing insects and a nest are disclosed. The methods may be used to disrupt a colony of nestdwelling insects. The insects may include wasps, hornets, and yellowjackets.Type: ApplicationFiled: September 30, 2011Publication date: April 12, 2012Applicant: STERLING INTERNATIONAL INC.Inventors: Rodney G. Schneidmiller, Qing-He Zhang, Guiji Zhou, Doreen R. Hoover
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Patent number: 8133477Abstract: A composition comprising an inorganic particulate material in an amount of about 20 wt % to about 70 wt %, a carrier for the particulate material comprising a compound of formula (I) in an amount of about 1 wt % to about 70 wt %, a particulate material coating material in an amount of about 0 wt % to about 5 wt %, and a dispersing agent for the particulate material in an amount of about 0 wt % to about 5 wt %, based on the total weight of the composition, wherein one of R1 and R2 is a straight or branched chain C1-C30 alkoxy radical, and the non-alkoxy R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C30 alkyl radical.Type: GrantFiled: September 4, 2009Date of Patent: March 13, 2012Assignee: Hallstar Innovations Corp.Inventors: Craig A. Bonda, Anna Pavlovic, Jean Zhang
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Publication number: 20120046367Abstract: Disclosed is an essential oil composition with anti-free radical ability, which includes dl-Citronellol, Eugenol, cis/trans-Citral, Eugenol Methyl Ether and Thymol. It is confirmed that the essential oil composition of the present invention has superior anti-free radical ability and anti-oxidative ability according to the indices including DPPH free radical scavenging ability, ABTS+ free radical scavenging ability, metal ion chelating ability and reducing property, which are extensively used to determine the anti-oxidative ability of a substance.Type: ApplicationFiled: August 23, 2010Publication date: February 23, 2012Inventors: Kuang-Hway YIH, Hsiao-Fen WANG
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Publication number: 20120041073Abstract: Methods and compositions for stabilizing opsin protein in a vertebrate visual system are provided by administration of opsin-binding synthetic retinoids.Type: ApplicationFiled: August 24, 2011Publication date: February 16, 2012Applicants: REGENTS OF THE UNIVERSITY OF MINNESOTA, UNIVERSITY OF WASHINGTONInventors: KRZYSZTOF PALCZEWSKI, SHALESH KAUSHAL, VLADIMIR KUKSA, SYED M. NOORWEZ
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Publication number: 20120034288Abstract: The invention provides compositions for attracting noctuid moths, which include at least one pheromone and at least one enhancer. The enhancer is a naturally-occurring phytochemical compound. The enhancer is preferably trans-2, cis-6-nonadienal. The invention also provides lures and traps containing the composition for attracting noctuid moths, and methods for attracting, capturing, killing or sterilizing noctuid moths using the composition.Type: ApplicationFiled: August 4, 2010Publication date: February 9, 2012Inventor: GERALD H. MCKIBBEN
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Publication number: 20120009255Abstract: The present invention provides methods of treating a human or other mammal infected with a parasitic microorganism by administering an effective amount in unit dosage form of a C8-C16-alpha, beta-unsaturated aliphatic aldehyde, such as trans-2-dodecenal, to the human or other mammal. The parasitic microorganisms may include trypanosomes, bacteria, fungi and nematodes.Type: ApplicationFiled: September 16, 2011Publication date: January 12, 2012Applicant: Slippery Rock University Foundation, Inc.Inventors: WAYNE M. FORBES, Carolyn S. Steglich
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Publication number: 20120003181Abstract: The present invention describes a novel retinoid-responsive nucleic acid, and a novel protein. Further, the invention describes the use of such a nucleic acid or protein in various diseases, and for the treatment, the diagnosis and prognosis of various diseases, and also for a method for the prognosis of responsiveness to retinoids.Type: ApplicationFiled: June 9, 2009Publication date: January 5, 2012Inventors: Johan R. Lillehaug, Pendino Frederic
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Patent number: 8070989Abstract: The photostabilizing electronic excited state energy—particularly singlet state energy from retinoid compounds—has been found to be readily transferred to (accepted by) ?-cyanodiphenylacrylate compounds having an alkoxy radical in the four (para) position (hereinafter “alkoxycrylenes”) on one of the phenyl rings having the formula (I): wherein one of R1 and R2 is a straight or branched chain C1-C30 alkoxy radical, preferably C1-C8, more preferably methoxy, and the non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C30 alkyl radical, preferably C2-C20. The alkoxycrylene compounds of formula (I) significantly increase the photostability of retinoid compounds in a composition by at least 3-fold and as much as 10-fold or greater. The ability of the alkoxycrylene compounds to stabilize the retinoid compound is concentration dependent, with the amount of retinoid photostabilization increasing with the concentration of the alkoxycrylene compound.Type: GrantFiled: July 31, 2009Date of Patent: December 6, 2011Assignee: Hallstar Innovations Corp.Inventors: Craig A. Bonda, Anna Pavlovic, Jean Zhang
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Publication number: 20110257255Abstract: The presently claimed and disclosed invention(s) provides a therapeutically effective composition and method of inhibiting nerve cell transmission. In a preferred embodiment of the presently claimed and disclosed invention(s), the treatment of neuropathic pain utilizing terpene compounds isolated from plant essential oils or manufactured synthetically is detailed. These compounds, such as geraniol and citronellol, as well as chemical analogs thereof, used in combination or individually, can be used alone or in a composition with a pharmaceutically acceptable carrier in a suitable dosage form.Type: ApplicationFiled: August 6, 2009Publication date: October 20, 2011Inventors: Alexander McLellan, Frank Greenway
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Publication number: 20110244062Abstract: The present invention relates to a composition inhibiting or destroying at least one living or unicellular organism, which comprises at least one anti-infectious agent and one activating agent, which consists of an extract made from dehydrated and partially sodium-free seawater or an extract made from a dried fossil sea with a similar composition. The present invention also relates to the utilization of such a composition.Type: ApplicationFiled: February 14, 2011Publication date: October 6, 2011Applicant: AROMAPHARM IRELAND LTD.Inventors: Pierre LAGNY, Jean-Jacques HERAULT
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Publication number: 20110245307Abstract: The present invention relates to compositions comprising a combination of PKC activators and PKC inhibitors and methods to modulate ?-secretase activity; improve or enhance cognitive ability; and/or reduce neurodegeneration in individuals suffering from diseases that impair cognitive ability, particularly Alzheimer's Disease. The invention also relates to methods for improving or enhancing cognitive ability. The present invention also provides methods for increasing the generation of non-amyloidogenic soluble APP (sAPP) comprising the activation of protein kinase C (PKC) in the brain and inhibiting PKC in peripheral tissues. Macrocyclic lactones (i.e. bryostatin class and neristatin class) are preferred PKC activators and Vitamin E is a preferred PKC inhibitor for use in the inventive composition.Type: ApplicationFiled: March 8, 2011Publication date: October 6, 2011Applicant: BLANCHETTE ROCKEFELLER NEUROSCIENCES INSTITUTEInventor: Daniel L. Alkon
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Publication number: 20110218245Abstract: The object of the present invention is the use of compounds designed to inhibit the activity of the enzyme 5?-reductase. This is a novel use of compounds of general formula (I): CH3(—CH?CH)n—R??(I) where n=from 2 to 7, and R is chosen from among: CHO, CH2OH, CH2O—CO—R?, CO—O(?), where R? is chosen from among H, and the alky from C1 to C22, each compound of general formula (I) being used as such or in mixtures with other compounds, as the active principle in a pharmaceutical or cosmetic composition designed to inhibit the action of the enzyme 5?-reductase, and of the pharmaceutical or cosmetic compositions deriving therefrom.Type: ApplicationFiled: November 10, 2009Publication date: September 8, 2011Applicant: GIULIANI S.P.A.Inventors: Giammaria Giuliani, Anna Benedusi, Sergio Baroni
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Patent number: 8007771Abstract: The present invention relates to oral care compositions comprising stannous ions, a mint-type flavor oil, a protectant component that prevents generation of off odor and off taste in the composition, and orally acceptable carriers. The mint-type oils include peppermint, spearmint and corn mint. Suitable protectant components include copper salts and carbonyl compounds such as ascorbic acid; cis-jasmone; 2,5-dimethyl-4-hydroxy-3(2H)-furanone; 5-ethyl-3-hydroxy-4-methyl-2(5H)-furanone; vanillin; ethyl vanillin; anisaldehyde; 3,4-methylenedioxybenzaldehyde; 3,4-dimethoxybenzaldehyde; 4-hydroxybenzaldehyde; 2-methyoxybenzaldehyde; 4-methoxybenzaldehyde; benzaldehyde; cinnamaldehyde (3-phenyl-2-propenal); hexyl cinnamaldehyde; ?-methyl cinnamaldehyde; ortho-methoxy cinnamaldehyde; ?-amyl cinnamaldehyde; and combinations thereof. The oral care composition may be a dentifrice.Type: GrantFiled: July 5, 2007Date of Patent: August 30, 2011Assignee: The Procter & Gamble CompanyInventors: Niranjan Ramji, Marc Hester, Steve Hoke, Robert Leslie Swaine, Jr., Gerhard Norbert Zehentbauer
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Publication number: 20110206626Abstract: A skin care product comprising from about 0.001% to about 10% of a retinoid, in combination with 0.0001% to about 50% of a combination of retinoid boosters.Type: ApplicationFiled: April 29, 2011Publication date: August 25, 2011Applicant: CONOPCO, INC., D/B/A UNILEVERInventors: Stewart Paton Granger, Ian Richard Scott, Robert Mark Donovan, Susanne Teklits Iobst, Lisa Licameli
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Patent number: 7968605Abstract: A method is disclosed for treating inflammatory disease in an animal in need thereof by administering to the animal a pharmaceutical composition containing an anti-inflammatory effective amount of an organic aldehyde compound or a derivative thereof in a pharmaceutically acceptable vehicle.Type: GrantFiled: February 6, 2007Date of Patent: June 28, 2011Assignee: ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda.Inventors: Marta Norton De Matos, Carlos C. Romao
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Publication number: 20110151029Abstract: Cosmetic compositions comprising one or more paxillin stimulators and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The paxillin stimulators and combinations thereof are believed to have modulatory activity against at least one biochemical pathway implicated in skin aging.Type: ApplicationFiled: December 13, 2010Publication date: June 23, 2011Applicant: Avon Products, Inc.Inventors: Qian ZHENG, Russell WYBORSKI, Uma SANTHANAM, John W. LYGA, Dmitri S. PTCHELINTSEV, Siming W. CHEN
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Publication number: 20110142771Abstract: The photostabilizing electronic excited state energy—particularly singlet state energy from retinoid compounds—has been found to be readily transferred to (accepted by) ?-cyanodiphenylacrylate compounds having an alkoxy radical in the four (para) position (hereinafter “alkoxycrylenes”) on one of the phenyl rings having the formula (I): wherein one of R1 and R2 is a straight or branched chain C1-C30 alkoxy radical, preferably C1-C8, more preferably methoxy, and the non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C30 alkyl radical, preferably C2-C20. The alkoxycrylene compounds of formula (I) significantly increase the photostability of retinoid compounds in a composition by at least 3-fold and as much as 10-fold or greater. The ability of the alkoxycrylene compounds to stabilize the retinoid compound is concentration dependent, with the amount of retinoid photostabilization increasing with the concentration of the alkoxycrylene compound.Type: ApplicationFiled: February 22, 2011Publication date: June 16, 2011Applicant: HALLSTAR INNOVATIONS CORP.Inventors: Craig A. Bonda, Anna Pavlovic, Jean Zhang
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Publication number: 20110136918Abstract: The present invention provides methods of treating a human or other mammal infected with a parasitic microorganism by administering an effective amount in unit dosage form of a C8-C16-alpha, beta-unsaturated aliphatic aldehyde, such as trans-2-dodecenal, to the human or other mammal. The parasitic microorganisms may include trypanosomes, bacteria, fungi and nematodes.Type: ApplicationFiled: February 16, 2011Publication date: June 9, 2011Applicant: SLIPPERY ROCK UNIVERSITY FOUNDATION, INC.Inventors: Wayne M. Forbes, Carolyn S. Steglich
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Patent number: 7910114Abstract: The present invention provides methods of treating a human or other mammal infected with a parasitic microorganism by administering an effective amount in unit dosage form of a C8-C16-alpha, beta-unsaturated aliphatic aldehyde, such as trans-2-dodecenal, to the human or other mammal. The parasitic microorganisms may include trypanosomes, bacteria, fungi and nematodes.Type: GrantFiled: August 15, 2007Date of Patent: March 22, 2011Assignee: Slippery Rock University FoundationInventors: Wayne M. Forbes, Carolyn Steglich
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Publication number: 20110059159Abstract: Methods for rapidly obtaining a nanoscale apolipoprotein bound phospholipid bilayer (NABB) associated with at least one membrane protein are provided. Also disclosed are methods for rapidly obtaining a NABB not associated with membrane proteins. Immunogenic compositions comprising NABBs with native conformational epitopes are also provided along with their methods of use.Type: ApplicationFiled: January 30, 2009Publication date: March 10, 2011Applicant: THE ROCKEFELLER UNIVERSITYInventors: Thomas P. Sakmar, Thomas Huber, Sourabh Banerjee
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Publication number: 20110046234Abstract: The present invention is directed to methods of treating a patient for a disease or condition associated with adipogenesis or insulin resistance by administering a retinaldehyde compound to the patient or a compound that increases endogenous retinaldehyde levels by inhibiting the enzyme retinaldehyde dehydrogenase 1.Type: ApplicationFiled: February 27, 2009Publication date: February 24, 2011Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Jorge Plutzky, Ouliana Ziouzenkova
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Publication number: 20110034554Abstract: Methods of retarding formation of a lipofuscin pigment in the retina and of treating or ameliorating the effects of a disease characterized by an accumulation of a lipofuscin pigment in a retina are provided. These methods include the step of administering to a patient in need thereof a substituted C20-retinoid in an amount sufficient to reduce accumulation of a lipofuscin pigment in the retina. Further provided are methods of retarding formation of A2E and/or ATR-dimer by replacing an all-frans-retinal (ATR) substrate with a C20-D3-retinal substrate under conditions sufficient to impede the formation of A2E. Compositions for retarding formation of a lipofuscin pigment in the retina containing a substituted C20-retinoid and a pharmaceutically acceptable carrier are also provided.Type: ApplicationFiled: September 12, 2008Publication date: February 10, 2011Inventor: Ilyas Washington
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Publication number: 20110009333Abstract: Disorders of the skin or mucous membranes which are linked to migration of Langerhans cells are treated by the administration of an effective amount of at least one retinoid, optionally in combination with a PKC inhibitor.Type: ApplicationFiled: September 17, 2010Publication date: January 13, 2011Inventors: Philippe MSIKA, Nathalie PICCARDI, Antoine PICCIRILLI
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Patent number: 7834057Abstract: Compositions for the treatment of the skin. The compositions reduce and/or reverse the visible appearance of skin damage. In the preferred embodiment, the composition includes Retinyl Palmitate Polypeptide; Ascorbylmethylsilanol Pectinate; Tocopheryl Polypeptide; Cholecalciferol Polypeptide; and Niacinamide Polypeptide.Type: GrantFiled: August 3, 2001Date of Patent: November 16, 2010Inventor: Simon Erani
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Publication number: 20100273801Abstract: The invention relates to compouns derived from betulin, and to the use thereof as antibacterial agents in pharmaceutical and cosmetic applications.Type: ApplicationFiled: June 6, 2007Publication date: October 28, 2010Applicant: Valition teknillinen tutikimuskeskusInventors: Jari Yli-Kauhaluoma, Salme Koskimies, Sami Alakurtti, Taru Mäkelä, Päivi Tammela
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Publication number: 20100272818Abstract: The present invention relates to compositions comprising terpenes which are particularly suitable for treating plant infections, to methods of making such compositions, and to methods of using them. The present invention also relates to compositions comprising terpenes and hollow glucan particles or cell wall particles and methods for preparing such compositions; such compositions increase terpene stability and activity and provide a suitable carrier for the terpenes. The invention also relates to methods of using such compositions in the medical, veterinary and agricultural fields. In particular, the terpenes disclosed are thymol, eugenol, geraniol, citral and L-carvone.Type: ApplicationFiled: August 3, 2006Publication date: October 28, 2010Inventors: Lanny Franklin, Elizabeth Cloud, Lanna Knapp, Gary Ostroff
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Publication number: 20100189818Abstract: Methods and compositions are provided for treating neuropsychiatric disorders such as schizophrenia, depression, attention deficit disorder, mild cognitive impairment, dementia, and bipolar disorder. The methods entail administering to a patient diagnosed as having a neuropsychiatric disorder (e.g., schizophrenia, depression, attention deficit disorder, mild cognitive impairment, dementia bipolar disorder, etc.) or as at risk for a neuropsychiatric disorder a benzoic acid, benzoic acid salt, and/or benzoic acid derivative, and/or a sorbic acid, sorbic acid salt, and/or sorbic acid derivative, in combination with a neuropharmacological agent (e.g., an antipsychotic, an antidepressant, medications for attention deficit and hyperactivity disorder, cognitive impairment, or dementia, etc.) where the benzoic acid, benzoic acid salt, or benzoic acid derivative, and/or a sorbic acid, sorbic acid salt, and/or sorbic acid derivative, is in an amount sufficient to increase the efficacy of the neuropharmacological agent.Type: ApplicationFiled: January 19, 2010Publication date: July 29, 2010Applicant: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical CenterInventor: GUOCHUAN EMIL TSAI
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Publication number: 20100168231Abstract: The use of an enzyme as a research tool for acne, by identifying a compound for the treatment of acne and/or any disorder associated with cutaneous hyperseborrhoea.Type: ApplicationFiled: January 5, 2010Publication date: July 1, 2010Applicant: GALDERMA RESEARCH & DEVELOPMENTInventors: Laurent Lamy, Michel Rivier, Gérard Feraille
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Publication number: 20100136108Abstract: A new pharmaceutical formulation for retinoid-containing soft gelatin capsules is disclosed. The new formulation comprises a soft gelatin capsule filled with a fill mass comprising a retinoid as an active ingredient, a natural vegetable oil, a partially hydrogenated natural vegetable oil and medium chain triglycerides. Optionally, the new formulation also comprises a natural wax. In a particularly preferred embodiment, the soft gelatin capsule comprises pig gelatin in the capsule shell in combination with the above fill mass.Type: ApplicationFiled: December 17, 2009Publication date: June 3, 2010Inventors: Günter Ditzinger, Bernhard Gabriel, Anne-Hortense Schmitt-Hoffmann, Lutz Wevelsiep
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Publication number: 20100136102Abstract: The present invention relates to compositions comprising terpenes and hollow glucan particles or cell wall particles and methods for preparing such compositions. The compositions increase terpene stability and activity and provide a suitable carrier for the terpenes. The invention also relates to methods of using such compositions,in the medical, veterinary and agricultural fields.Type: ApplicationFiled: August 3, 2006Publication date: June 3, 2010Inventors: Lanny Franklin, Elizabeth Cloud, Lanna Knapp, Gary Ostroff, Gary Harman
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Publication number: 20100120911Abstract: Disclosed is a novel method for preserving cosmetic/personal care formulations through a two component preservative system, said system comprising (a) Component I which functions to eliminate the existing microbial contamination load in a natural cosmetic formulation base through an optimized pasteurization method that avoids deep freezing; and (b) Component II that includes the step of adding synergistic blends of fractionated essential oils, extracts and isolated compounds to the pre-pasteurized cosmetic base obtained through the method of component I, wherein the synergistic blends sustain the effects of pasteurization through anti-microbial and anti-oxidant effects, said anti-oxidant effects enhancing further the anti-microbial effects by virtue of inhibiting lipid per oxidation that facilitates the undue proliferation of microbe.Type: ApplicationFiled: May 4, 2009Publication date: May 13, 2010Inventors: Muhammed Majeed, Beena Bhat, Garima Agarwal
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Patent number: 7709534Abstract: Infections caused by parasitic nematodes of the genera Strongyloides, Ancyclostoma, Necator, Haemonchus, Ascaris, or Trichuris in humans and other mammals are treated by administration to an infected individual of an amount of a C8-C16-alpha,beta-unsaturated aliphatic aldehyde. Such compounds are useful for killing nematode worms of the genera listed above. A particularly useful compound of this class, effective against S. stercoralis infections, is E-2-dodecenal, having structural formula (1).Type: GrantFiled: April 28, 2003Date of Patent: May 4, 2010Assignee: University of the West IndiesInventors: Wayne M. Forbes, Ralph D. Robinson, Paul B. Reese
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Publication number: 20100104644Abstract: Methods are disclosed for treating or preventing ophthalmic conditions related to a toxic visual cycle product. Compounds and compositions useful in these methods, either alone or in combination with other therapeutic agents, are also described, along with methods of screening for new agents useful in said the therapeutic and prophylactic methods of the invention.Type: ApplicationFiled: July 27, 2007Publication date: April 29, 2010Applicant: University of Florida Research Foundation, Inc.Inventors: Shalesh Kaushal, Syed Mohammed Noorwez
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Publication number: 20100034907Abstract: An aqueous disinfectant formulation comprising at least one phenolic compound of natural origin; a surfactant sufficient to form a solution or dispersion of the essential oil in an aqueous carrier; a solvent, and sufficient water to make 100 weight percent is described herein.Type: ApplicationFiled: April 8, 2009Publication date: February 11, 2010Applicant: Laboratoire M2Inventors: François Daigle, Ann Letellier, Sylvain Quessy
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Publication number: 20100035986Abstract: A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.Type: ApplicationFiled: February 10, 2009Publication date: February 11, 2010Applicant: UNIVERSITY OF WASHINGTONInventors: Tadao Maeda, David Saperstein, Krzysztof Palczewski
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Publication number: 20100028464Abstract: Use of saffron and its active ingredients, such as safranal and/or picrocrocin and/or crocin and/or derivatives thereof, for the production of an active satiation agent for the treatment of problems of overweight.Type: ApplicationFiled: April 23, 2007Publication date: February 4, 2010Inventor: Cedric Bourges
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Patent number: 7655253Abstract: The present invention provides compounds useful for preparing synthetic pheromone compositions that can be used as attractants or inhibitors of insect species. The compositions are useful in the control of navel orangeworm or meal moth insect pests.Type: GrantFiled: January 24, 2006Date of Patent: February 2, 2010Assignees: Bedoukian Research, Inc., The Regents of the University of California, The United States of America Secretary of AgricultureInventors: Lodewyk P. S. Kuenen, Walter S. Leal, Jocelyn G. Millar, Douglas J. Pesak, Ana Lia Parra Pedrazzoli, Frank G. Zalom
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Publication number: 20090324570Abstract: The photostabilizing electronic excited state energy—particularly singlet state energy from retinoid compounds—has been found to be readily transferred to (accepted by) ?-cyanodiphenylacrylate compounds having an alkoxy radical in the four (para) position (hereinafter “alkoxycrylenes”) on one of the phenyl rings having the formula (I): wherein one of R1 and R2 is a straight or branched chain C1-C30 alkoxy radical, preferably C1-C8, more preferably methoxy, and the non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C30 alkyl radical, preferably C2-C20. The alkoxycrylene compounds of formula (I) significantly increase the photostability of retinoid compounds in a composition by at least 3-fold and as much as 10-fold or greater. The ability of the alkoxycrylene compounds to stabilize the retinoid compound is concentration dependent, with the amount of retinoid photostabilization increasing with the concentration of the alkoxycrylene compound.Type: ApplicationFiled: July 31, 2009Publication date: December 31, 2009Applicant: HALLSTAR INNOVATIONS CORP.Inventors: Craig A. Bonda, Anna Pavlovic, Jean Zhang