Acyclic Carbon To Carbon Unsaturation Patents (Class 514/720)
  • Patent number: 10265276
    Abstract: Disclosed herein is a pharmaceutical composition for treating or preventing inflammatory diseases or arthritis, which includes 2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition exhibits superior therapeutic efficacy against arthritis without any side effects such as toxicity, etc.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: April 23, 2019
    Assignee: CHUNGBUK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Jin Tae Hong, Hee Pom Lee, Young Wan Ham, Chun Sik Kim, Heon Sang Jung, Dae Hwan Kim
  • Patent number: 9980924
    Abstract: A chemoprotective method for treating, inhibiting or preventing loss of barrier function in skin caused by ultraviolet (UV) light by using an effective amount of pterostilbene is provided. Pharmaceutical and nutraceutical compositions containing pterostilbene suitable for administration to an individual in order to prevent subsequent UV-mediated loss of barrier function in skin are provided.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: May 29, 2018
    Assignee: The Regents of the University of California
    Inventors: Frank L. Meyskens, Ryan W. Dellinger
  • Patent number: 9957224
    Abstract: Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: May 1, 2018
    Assignee: ACUCELA INC
    Inventors: Claes Olof Bavik, Susan Hayes Henry, Ryo Kubota, Vladimir A. Kuksa
  • Patent number: 9782755
    Abstract: A nickel-supported catalyst for combined steam and carbon dioxide reforming, as a catalyst which is used in a process of preparing a synthesis gas by combined steam and carbon dioxide reforming with natural gas, is provided. More particularly, in the nickel-supported catalyst, nickel is supported as an active metal on a lanthanum oxide support.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: October 10, 2017
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Dong Ju Moon, Eun Hyeok Yang, Gi Hoon Hong, Sung Soo Lim, Jae Sun Jung, Young Su Noh, Na Young Kim, Jae Suk Lee, Ji In Park, Sang Yong Lee
  • Patent number: 9241915
    Abstract: This invention relates to a method for enhancing the bioavailability of a therapeutically active compound of the formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, wherein said compound is administered orally to the individual in connection with the intake of food.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: January 26, 2016
    Assignee: QuatRx Pharmaceuticals
    Inventor: Markku Anttila
  • Patent number: 9040507
    Abstract: A method for treating an autoimmune disease in a subject includes administering to the subject a therapeutically effective amount of an agent comprising an imidazole, an estrogen receptor agonist, or pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: May 26, 2015
    Assignee: Novelmed Therapeutics, Inc.
    Inventor: Rekha Bansal
  • Publication number: 20150126613
    Abstract: This invention concerns a method for treatment or prevention of lower urinary tract symptoms with or without pelvic pain in an individual, said method comprising administering to the individual an effective amount of a selective estrogen receptor modulator, or an isomer, isomer mixture or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: January 15, 2015
    Publication date: May 7, 2015
    Inventors: Risto Santti, Tomi Streng
  • Patent number: 8999399
    Abstract: The invention relates to a novel combined disinfection and decontamination agent comprising at least one vitamin, at least one metal ion, at least one active-surface compound, and at least one further antimicrobial active substance. The agent according to the invention surprisingly shows nearly complete nucleic acid disintegration in addition to an improved disinfectant effect. The agent can be successfully used as a combined decontamination and disinfection agent for skin, mucous membranes, hands, wounds, and/or hair, and instruments and surfaces of all kinds.
    Type: Grant
    Filed: November 14, 2009
    Date of Patent: April 7, 2015
    Assignee: Bose Chemie GmbH
    Inventors: Thomas Lisowsky, Sven Eggerstedt, Richard Bloss, Christiane Ostermeyer, Karlheinz Esser, Frank Bürger, Barbara Krug, Yvonne Feil, Kai-Martin Mueller, Delphine Haase
  • Patent number: 8969326
    Abstract: The present invention relates to methods and compositions for treating a subject suffering from a sclerosing disorder, comprising administering, to the subject, an effective amount of an estrogen receptor antagonist (“ERANT”), wherein said ERANT has essentially no estrogen receptor agonist activity under physiologic conditions.
    Type: Grant
    Filed: January 18, 2012
    Date of Patent: March 3, 2015
    Assignee: University of Pittsburgh—Of The Commonwealth System Of Higher Education
    Inventors: Carol A. Feghali-Bostwick, Pamela Anne Hershberger
  • Publication number: 20150057366
    Abstract: The present invention is directed to the synthesis of elemicin and its isomeric form, and their use in topical analgesic formulations, including for dental and veterinary use. Various compositions include gels, films, dressings, cavity filling gels, having analgesic and/or antifungal properties.
    Type: Application
    Filed: March 5, 2013
    Publication date: February 26, 2015
    Inventor: Martin James LA GRANGE
  • Publication number: 20150051295
    Abstract: The invention relates to the use of propanol and propenol derivatives as antioxidants, to compositions comprising propanol and propenol derivatives and the preparation thereof, and to certain propanol and propenol derivatives and the preparation thereof.
    Type: Application
    Filed: September 27, 2012
    Publication date: February 19, 2015
    Applicant: MERCK PATENT GMBH
    Inventors: Thomas Rudolph, Rene Peter Scheurich
  • Publication number: 20150038468
    Abstract: The present invention relates to methods and compositions for treating a subject suffering from a sclerosing disorder, comprising administering, to the subject, an effective amount of an estrogen receptor antagonist (“ERANT”), wherein said ERANT has essentially no estrogen receptor agonist activity under physiologic conditions.
    Type: Application
    Filed: October 20, 2014
    Publication date: February 5, 2015
    Inventors: Carol A. Feghali-Bostwick, Pamela Anne Hershberger
  • Publication number: 20150011650
    Abstract: A method is provided for treating an individual for a cellular proliferative disorder, including administering to the individual in need of such treatment a therapeutically effective amount of the compound pterostilbene wherein UDP-glucuronosyltransferase (UGT) activity is increased. In an embodiment, 12-HETE levels can be reduced by administration of pterostilbene.
    Type: Application
    Filed: September 22, 2014
    Publication date: January 8, 2015
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, CHROMADEX INC.
    Inventors: Jeremy Bartos, Ryan Dellinger
  • Publication number: 20150010520
    Abstract: CoQ10 and vitamin E are both lipid-soluble nutrients with redox potential. Tocopherol and/or tocotrienol protect CoQ10 from oxidative damage and reduce ubiquinone in situ. Specifically, vitamin E protects the oxidation of ubiquinol to ubiquinone ex vivo and reduces ubiquinone to ubiquinol in situ. Vitamin Es with higher ratio of tocotrienol-to-tocopherol cause a higher ratio of ubiquinol-to-ubiquinone. Additionally tocopherol and/or tocotrienol protect vitamin A oxidation from retinol to retinoic acid.
    Type: Application
    Filed: July 3, 2014
    Publication date: January 8, 2015
    Inventor: Barrie TAN
  • Patent number: 8906960
    Abstract: A transdermal fluid is provided wherein the main ingredient is tocotrienol and curcumin is added to enhance the anti-cancer effects of tocotrienols. The composition is useful for the treatment or prevention of a cancer, a tumor or an inflammatory disorder, particularly breast cancer.
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: December 9, 2014
    Assignee: Malaysian Palm Oil Board
    Inventors: Kalanithi Nesaretnam, Kanga Rani Selvaduray
  • Publication number: 20140348959
    Abstract: Compositions and methods for treatment of conditions such as ear pain are disclosed.
    Type: Application
    Filed: August 12, 2014
    Publication date: November 27, 2014
    Inventors: Mark A. Mitchnick, Garry Gwozdz
  • Publication number: 20140329910
    Abstract: Provided are a cooling agent having an excellent TRPM8 activating action, a TRPM8 activator, a method for imparting cooling sensation, and a novel compound useful for imparting cooling sensation.
    Type: Application
    Filed: November 19, 2012
    Publication date: November 6, 2014
    Applicant: Kao Corporation
    Inventors: Tomohiro Shirai, Hiroshi Kusuoku, Mitsuyoshi Sakasai
  • Publication number: 20140322366
    Abstract: A coniferyl alcohol or a Compositae family, Brassicaceae family, Umbelliferae family, Lamiaceae family, Liliaceae family or Amaranthaceae plant extract provides various uses associated with hTRPA1 activation, and, being a natural compound, involves relatively few side effects in the body and has substantial industrial applicability. The coniferyl alcohol or the Compositae family, Brassicaceae family, Umbelliferae family, Lamiaceae family, Liliaceae family or Amaranthaceae plant extract of the present invention not only will be a novel medical or food raw material which is helpful in maintaining homeostasis in the body associated with hTRPA1 activation, but can also be used to advantage in hTRPA1 antagonist screening.
    Type: Application
    Filed: November 9, 2012
    Publication date: October 30, 2014
    Applicant: KOREA FOOD RESEARCH INSTITUTE
    Inventors: Mee Ra Rhyu, Hee Jin Son, Yi Seul Kim, Seo Hyeon Song, Min Jung Kim, Myung Ji Jung, Hye Jin Lee, Hye Young Kim, Jae-Ho Park
  • Publication number: 20140314840
    Abstract: The present invention is directed to compositions and methods of delivery of CoQ that is reduced in the presence of lipoic acid and, optionally a fatty acid and/or optionally in a monoterpene. The compositions that include the reduced CoQ can be formulated in soft gel capsules.
    Type: Application
    Filed: June 30, 2014
    Publication date: October 23, 2014
    Inventor: Michael Fantuzzi
  • Patent number: 8865775
    Abstract: An anti-inflammatory agent or cancer-preventive agent comprising 4-vinyl-2,6-dimethoxyphenol of the formula (1): or a PD thereof.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: October 21, 2014
    Inventors: Hiroshi Maeda, Tetsuya Tsukamoto, Masae Tatematsu
  • Publication number: 20140303259
    Abstract: This invention relates to a method for enhancing the bioavailability of a therapeutically active compound of the formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, wherein said compound is administered orally to the individual in connection with the intake of food.
    Type: Application
    Filed: June 20, 2014
    Publication date: October 9, 2014
    Inventor: Markku Anttila
  • Patent number: 8853270
    Abstract: The present invention relates to stilbene and quinine compounds related to combretastatin A-4 and their use as anticancer compounds and prodrugs. The compounds include those with an alkyl group on the double bond of cis- or trans-stilbenes, compounds with one or more (and preferably 2 or 3) alkyl group substituents on the stilbene A ring, compounds with an alkoxy group other than methoxy at position 3, 4, and/or 5 of the stilbene A ring, compounds (or prodrugs) in which BBOC amino acid esters are formed with the phenolic hydroxyl at the 3-position of the B ring and compounds (or prodrugs) based on a benzoquinone B ring. The present invention further relates to the photochemical reactions of stilbene compounds, either the above compounds disclosed for the first time herein or compounds based on prior stilbenes.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: October 7, 2014
    Assignee: University of Salford
    Inventors: John Anthony Hadfield, Alan Thomson McGown, Stephen Patrick Mayalarp, Edward John Land, Ian Hamblett, Keira Gaukroger, Nicholas James Lawrence, Lucy Annette Hepworth, John Butler
  • Patent number: 8841350
    Abstract: A method is provided for treating an individual for a cellular proliferative disorder, including administering to the individual in need of such treatment a therapeutically effective amount of the compound pterostilbene wherein UDP-glucuronosyltransferase (UGT) activity is increased. In an embodiment, 12-HETE levels can be reduced by administration of pterostilbene.
    Type: Grant
    Filed: May 8, 2012
    Date of Patent: September 23, 2014
    Assignees: ChromaDex Inc., The Regents of the University of California
    Inventors: Jeremy Bartos, Ryan Dellinger
  • Publication number: 20140274682
    Abstract: Methods for reducing dust emission by coating a seed with a lubricant composition are described herein. The disclosure also provides for a method of reducing insect exposure to vacuum planter dust released during seed planting by applying a lubricant composition to a seed. Methods for increasing seed lubricity by coating a seed with a lubricant composition are also described. Compositions and seeds useful in these methods are also described.
    Type: Application
    Filed: March 5, 2014
    Publication date: September 18, 2014
    Applicant: Bayer CropScience LP
    Inventors: Tai-Teh WU, Dick ROGERS, Jian ZHANG, Robert CROFT, Chi Yu Roy CHEN, Ronald REICHERT, William G. HAIRSTON
  • Publication number: 20140256827
    Abstract: Disclosed is a pharmaceutical composition for treating oxidative stress comprising a therapeutically effective amount of a substantially pure compound of pterostilbene and a physiologically acceptable carrier. Pterostilbene is administered in an amount between about 2.5 mg to about 10 mg per kilogram of subject body weight. Also disclosed is a method for increasing a working memory of a subject, the method comprising administrating an effective amount of a substantially pure compound of pterostilbene, wherein the working memory for a subject increase and the therapeutic effectiveness is about 10 mg of pterostilbene per kilogram of subject body weight.
    Type: Application
    Filed: May 22, 2014
    Publication date: September 11, 2014
    Inventors: James A. Joseph, Agnes M. Rimando, Barbara Shukitt-Hale
  • Publication number: 20140256826
    Abstract: The present document describes a method of reducing a microbial presence on at least one part of a subject by topically contacting the subject's part with an antimicrobial formulation comprising: a) at least one antimicrobial isolated or synthetic phenolic compound of natural origin; b) at least one surfactant sufficient to form a solution or dispersion of said phenolic compound in an aqueous carrier; c) a solvent for dissolving said phenolic compound; and d) a sufficient aqueous carrier quantity to make 100% (w/w).
    Type: Application
    Filed: March 8, 2013
    Publication date: September 11, 2014
    Applicant: Laboratoire M2
    Inventors: Gaetan LEMIRE, Ulysse DESRANLEAU DANDURAND, Sylvain QUESSY, Ann LETELLIER
  • Publication number: 20140248263
    Abstract: Compounds having a structure of Formula I: wherein G, a, Q, L2, R1, R2, R3, R4, R5 and R6 are as defined herein are provided. Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.
    Type: Application
    Filed: April 6, 2012
    Publication date: September 4, 2014
    Applicants: THE UNIVERSITY OF BRITISH COLUMBIA, BRITISH COLUMBIA CANCER AGENCY BRANCH
    Inventors: Raymond John Andersen, Javier Garcia Fernandez, Marianne Dorothy Sadar, Nasrin Mawji, Carmen Adriana Banuelos, Jun Wang
  • Publication number: 20140249161
    Abstract: Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed. The halogenated stilbene analogs include nitrogen heteroaryl groups and/or amino groups on the stilbene ring.
    Type: Application
    Filed: February 27, 2014
    Publication date: September 4, 2014
    Applicant: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: David WATT, Chunming LIU, Vitaliy M. SVIRIPA, Wen ZHANG
  • Patent number: 8809400
    Abstract: Disclosed is a pharmaceutical composition for treating oxidative stress comprising a therapeutically effective amount of a substantially pure compound of pterostilbene and a physiologically acceptable carrier. Pterostilbene is administered in an amount between about 2.5 mg to about 10 mg per kilogram of subject body weight. Also disclosed is a method for increasing a working memory of a subject, the method comprising administrating an effective amount of a substantially pure compound of pterostilbene, wherein the working memory for a subject increase and the therapeutic effectiveness is about 10 mg of pterostilbene per kilogram of subject body weight.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: August 19, 2014
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventors: James A. Joseph, Agnes M. Rimando, Barbara Shukitt-Hale
  • Publication number: 20140220118
    Abstract: This invention relates to a solid drug formulation comprising granulates containing• a therapeutically active compound of the formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, in combination with one or more intra-granular excipients.
    Type: Application
    Filed: January 30, 2014
    Publication date: August 7, 2014
    Inventors: Veli-Matti LEHTOLA, Kaija HALONEN
  • Publication number: 20140220164
    Abstract: Compositions useful for controlling pests are disclosed. In some embodiments, the composition includes a pesticidal natural oil and a polar aromatic solvent or an alkyl alcohol solvent. Methods of making and using the compositions are disclosed.
    Type: Application
    Filed: April 8, 2014
    Publication date: August 7, 2014
    Applicant: 0903608 B.C. Ltd.
    Inventors: Karan MANHAS, Annett ROZEK
  • Patent number: 8796326
    Abstract: A fire ant killer chemical composition (the “FAK Composition”) for effective killing of fire ants where the FAK Composition utilizes a minimal amount of active ingredients thereby significantly reducing safety concerns with respect to the use of said active ingredients, the FAK composition having a dish detergent composition and an insecticide composition.
    Type: Grant
    Filed: January 4, 2012
    Date of Patent: August 5, 2014
    Inventor: Harold V. Hutchins
  • Patent number: 8772353
    Abstract: This invention relates to a method for enhancing the bioavailability of a therapeutically active compound of the formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, wherein said compound is administered orally to the individual in connection with the intake of food.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: July 8, 2014
    Assignee: Hormos Medical Ltd.
    Inventor: Markku Anttila
  • Patent number: 8758821
    Abstract: This invention relates to a liquid or semisolid oral drug formulation comprising a therapeutically active compound of the formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, in combination with a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: November 6, 2006
    Date of Patent: June 24, 2014
    Assignee: Hormos Medical Ltd.
    Inventors: Veli-Matti Lehtola, Soili Anttila, Esa Anttila, Pirkko Krikku, Pälvi Erkkilä
  • Publication number: 20140170198
    Abstract: The present invention relates to compositions comprising terpenes which are particularly suitable for treating plant infections, to methods of making such compositions, and to methods of using them. The present invention also relates to compositions comprising terpenes and hollow glucan particles or cell wall particles and methods for preparing such compositions; such compositions increase terpene stability and activity and provide a suitable carrier for the terpenes. The invention also relates to methods of using such compositions in the medical, veterinary and agricultural fields. In particular, the terpenes disclosed are thymol, eugenol, geraniol, citral and L-carvone.
    Type: Application
    Filed: February 25, 2014
    Publication date: June 19, 2014
    Applicant: Eden Research PLC
    Inventors: Lanny Franklin, Gary Ostroff
  • Publication number: 20140163116
    Abstract: The present invention is directed to treating cancer with a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I).
    Type: Application
    Filed: February 14, 2014
    Publication date: June 12, 2014
    Applicant: DePuy Synthes Products, LLC
    Inventor: Thomas M. DiMauro
  • Publication number: 20140142195
    Abstract: This invention relates to a method for inhibition of skin atrophy, or epithelial or mucosal atrophy in women, or to a method for treatment or prevention of symptoms related to said atrophy, said method comprising administering to the woman an effective amount of the compound of formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof.
    Type: Application
    Filed: January 24, 2014
    Publication date: May 22, 2014
    Applicants: HORMOS MEDICAL LTD.
    Inventors: Kaija HALONEN, Lauri KANGAS, Michael W. DEGREGORIO
  • Publication number: 20140127276
    Abstract: A method for removing airborne bacteria and airborne mycetes from indoor air comprises imparting microbiocidal and microbiostatic properties to fabric by treating the fabric with one or more naturally occurring biocides, positioning the treated fabric in a sheet-like orientation, and blowing indoor air through the fabric.
    Type: Application
    Filed: February 15, 2013
    Publication date: May 8, 2014
    Applicant: PHILADELPHIA UNIVERSITY
    Inventors: Diana R. Cundell, Brian R. George
  • Patent number: 8709454
    Abstract: At least one phytosphingosine salicylate derivative and at least one lysate of at least one microorganism of the genus Bifidobacterium. Composition, combination. Use, including cosmetic use for reinforcing the repair and regeneration capacity of an epithelium, especially an epidermis, in particular an aged epidermis.
    Type: Grant
    Filed: January 12, 2010
    Date of Patent: April 29, 2014
    Assignee: L'Oreal
    Inventors: David Amar, Bruno Bernard, Dominique Bernard, Isabelle Castiel
  • Publication number: 20140105908
    Abstract: Disclosed herein are methods and compositions for reducing the recurrence of prostate cancer and for treating prostate cancer.
    Type: Application
    Filed: May 3, 2012
    Publication date: April 17, 2014
    Applicant: UNIVERSITY OF ROCHESTER
    Inventor: Chawnshang Chang
  • Publication number: 20140107223
    Abstract: Topical, UBIQUINOL supplement compositions useful for treating skin by: reducing oxidative stress, adjunctively restoring “local” UBIQUINOL levels, revitalizing aged and/or U.V. damaged skin and regulating immune responses, including responses to inflammatory challenges; comprising: stabilized UBIQUINOL supplement, an emulsion of polydimethylsiloxane in a nonionic surfactant and skin penetrants.
    Type: Application
    Filed: October 12, 2012
    Publication date: April 17, 2014
    Applicant: WhiteHill Oral Technologies, Inc.
    Inventor: Dale G. BROWN
  • Publication number: 20140099368
    Abstract: The invention provides novel hydroxystilbene-containing dosage forms, processes for producing these dosage forms and the use thereof for the treatment of menopausal symptoms in women, juvenile oligomenorrhea and dysmenorrhea, primary and secondary amenorrhea or endometritis.
    Type: Application
    Filed: July 24, 2013
    Publication date: April 10, 2014
    Inventors: Peter Heger, Reinhard Rettenberger, Carl-Friedrich Spaich
  • Patent number: 8642079
    Abstract: This invention relates to a solid drug formulation comprising granulates containing a therapeutically active compound of the formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, in combination with one or more intra-granular excipients.
    Type: Grant
    Filed: February 23, 2004
    Date of Patent: February 4, 2014
    Assignee: Hormos Medical Corporation
    Inventors: Veli-Matti Lehtola, Kaija Halonen
  • Publication number: 20130345313
    Abstract: This invention concerns a method for treatment or prevention of lower urinary tract symptoms with or without pelvic pain in an individual, said method comprising administering to the individual an effective amount of a selective estrogen receptor modulator, or an isomer, isomer mixture or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 19, 2013
    Publication date: December 26, 2013
    Applicant: Hormos Medical Corporation
    Inventors: Risto Santti, Tomi Streng
  • Publication number: 20130338224
    Abstract: The invention concerns a decontaminating composition having simultaneously bactericidal, fungicidal and virocidal properties, comprising as active components eugenol, eugenol acetate, vanillin and carvacrol, characterized in that said active constituents are present in the following percentages by weight: at least about 12% eugenol, at least about 3% eugenol acetate, at least about 0.1% vanillin and at least about 0.5% carvacrol. Said decontaminating composition can be used as liquid or solid soaps. It can also impregnate in liquid form fabrics and nonwoven fabrics such as garments for medical use, bed sheets, slip covers, surgery drape, dressings and gauze such as those applied to the skin of serious burn victims.
    Type: Application
    Filed: August 7, 2013
    Publication date: December 19, 2013
    Applicant: HIGHTECH BIO-ACTIVITIES HOLDING GMBH
    Inventors: Hakima BELBACHIR, Jean ANGELIDIS
  • Publication number: 20130324614
    Abstract: This invention relates to a method for enhancing the bioavailability of a therapeutically active compound of the formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, wherein said compound is administered orally to the individual in connection with the intake of food.
    Type: Application
    Filed: May 29, 2013
    Publication date: December 5, 2013
    Applicant: Hormos Medical LTD.
    Inventor: Anttila Markku
  • Patent number: 8586635
    Abstract: The present invention is related to an antifungal composition for the inhibition of wood decay caused by wood rot fungi. The invention further comprises a method for the inhibition of wood decay with gallates.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: November 19, 2013
    Assignee: National Taiwan University
    Inventors: Shang-Tzen Chang, Fu-Lan Hsu, Hui-Ting Chang, Tsair-Bor Yen
  • Publication number: 20130296441
    Abstract: We have determined that pterostilbene demonstrates anti-obesity properties. Rats were fed a commercial obesogenic diet supplemented or not with pterostilbene: PT15 (low dose: 15 mg/kg body weight/d) or PT30 (high dose: 30 mg/kg body weight/d) for 6 weeks. Pterostilbene significantly reduced total adipose tissue mass (15.1% in the PT15 group; 22.9% in the PT30 group) without changes in food intake. The activities of lipogenic enzymes were reduced in white adipose tissue and liver. Activities of enzymes involved in liver fatty acid oxidation were significantly increased in the PT30 group. Low dose pterostilbene can reduce body fat by reducing lipogenesis in adipose tissue. At the high dose, two mechanisms contribute to reduction in body fat: (1) decrease in adipose tissue and liver lipogenesis, and (2) an increase in liver fatty acid oxidation.
    Type: Application
    Filed: May 3, 2012
    Publication date: November 7, 2013
    Inventors: Agnes Rimando, Maria del Puy Portillo
  • Publication number: 20130281411
    Abstract: Compositions are disclosed that contain an effective inflammatory-dermatological disease-treating or condition-treating active agent and a pharmaceutically-acceptable carrier or vehicle. Methods of using the compositions to treat a subject's skin are also disclosed.
    Type: Application
    Filed: June 17, 2013
    Publication date: October 24, 2013
    Inventor: Bryan B. Fuller
  • Publication number: 20130267588
    Abstract: The invention relates to hydroxytyrosol ethers derived from fatty alcohols and phenolic compounds of olive oil and the salts, solvates and hydrates thereof, which have an affinity for type 1 cannabinoid receptors (CB1) and which can: prevent the oxidation of low-density lipoprotein (LDL); and modulate the actions regulated by said receptor, such as inducing satiety, controlling intake and reducing body fat.
    Type: Application
    Filed: December 19, 2011
    Publication date: October 10, 2013
    Applicants: FUNDACIO IMIM, FUNDACION INSTITUTO MEDITERRANEO PARA EL AVANCE DE LA BIOTECNOLOGIA Y LA INVESTIGACION SANITARIA, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
    Inventors: Rafael De La Torre Fornell, Magin Farre Albaladejo, Maria Isabel Covas Planells, Montserrat Fito Colomer, Bruno Almeida Cotrim, Fernando Rodriguez De Fonseca, Juan Manuel Decara Del Olmo, Miguel Romero Cuevas, Jesus Joglar Tamargo, Pedro Clapes Saborit