Acyclic Carbon To Carbon Unsaturation Patents (Class 514/720)
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Publication number: 20030092774Abstract: A method for treating neoplastic, angiogenic, vascular, fibroblastic, immunosuppressive, infectious, metabolic, and/or constitutional irregularities of the eye and/or joint of a living subject, comprising the steps of: providing a living subject, wherein the living subject includes an affected ocular and/or joint area having a neoplastic, angiogenic, fibroblastic, immunosuppressive, infectious, metabolic, and/or constitutional irregularity; providing a combretastatin-A4 based medicament, wherein the combretastatin-A4 based medicament is capable of preventing microtubule assembly, inhibiting the proliferation of endothelial, eukaryotic, and neoplastic cells, or altering their shape and function, as well as providing an anti-inflammatory effect; associating a therapeutically effective concentration of the combretastatin based medicament with the affected ocular and/or joint area of the living subject; and decreasing the neoplastic, angiogenic, vascular, fibroblastic, immunosuppressive, infectious, metabolic andType: ApplicationFiled: October 11, 2002Publication date: May 15, 2003Inventors: Thomas M. Parkinson, Malgorzata Szlek, Lindsay B. Lloyd, David L. Vollmer
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Publication number: 20030060515Abstract: Disclosed is a method of treating an individual or animal with osteoarthritis. The method comprises administering to the individual or animal a therapeutically effective amount of a protein tyrosine kinase inhibitor.Type: ApplicationFiled: September 23, 2002Publication date: March 27, 2003Applicant: The Osteoarthritis Sciences, Inc. Liquidating TrustInventors: Thomas R. Sharpe, George W. Vasios, R. Nelson Campbell
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Publication number: 20030039675Abstract: Methods are provided for inhibiting stenosis or restenosis following vascular trauma in a mammalian host, comprising administering to the host a therapeutically effective dosage of a cytostatic agent and/or cytoskeletal inhibitor so as to biologically stent the traumatized vessel. Also provided is a method to inhibit or reduce vascular remodeling following vascular trauma, comprising administering an effective amount of a cytoskeletal inhibitor. Further provided are pharmaceutical compositions and kits comprising the therapeutic agents of the invention.Type: ApplicationFiled: November 27, 2001Publication date: February 27, 2003Applicant: Angiotech Pharmaceuticals, Inc.Inventors: Lawrence L. Kunz, John M. Reno
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Patent number: 6518261Abstract: The use of eugenol, alone and in combination with 2-methoxyestradiol (2-ME) in the context of prostate cancer prophylaxes and treatment.Type: GrantFiled: February 9, 2001Date of Patent: February 11, 2003Assignee: Oncology Sciences CorporationInventors: Thomas J. Slaga, Addanki P. Kumar, William Alworth
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Publication number: 20020193434Abstract: The present invention provides composition having as active ingredients a stilbene derivative and a platinum coordination compound which is highly efficacious and highly safe for treating tumors, particularly for the treatment of solid or malignant tumors and thus methods of cancer and tumor treatment using the composition are also provided.Type: ApplicationFiled: May 29, 2002Publication date: December 19, 2002Applicant: AJINOMOTO CO. INCInventors: Yoshihiro Morinaga, Yukio Nihei, Yasuyo Suga, Manabu Suzuki, Kazuo Ohishi, Akira Okano
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Publication number: 20020143069Abstract: The impact of lipoxin A4 (LXA4) and aspirin-triggered-lipoxins (ATL) was investigated in tumor necrosis factor (TNF&agr;)-initiated neutrophil (PMN) responses in vitro and in vivo using metabolically stable LX analogs. At concentrations as low as 1-10 nM, the LXA4 and ATL analogs each inhibited TNF&agr;-stimulated superoxide anion generation and IL-1&bgr; release by human PMN.Type: ApplicationFiled: January 11, 2002Publication date: October 3, 2002Inventor: Charles N. Serhan
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Patent number: 6448450Abstract: A diphenylethylene Pterocarpus marsupium is provided which is administered orally to decrease blood glucose levels in rats. The compound is an effective anti-diabetic agent that can reduce abnormality of glucose metabolism in diabetes.Type: GrantFiled: May 8, 1998Date of Patent: September 10, 2002Assignee: Calyx Therapeutics, Inc.Inventors: Bishwajit Nag, Satyanarayana Medicherla, Jai P. Chansouria, Anil B. Ray
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Patent number: 6444230Abstract: Composition in the form of an aqueous solution, useful for disinfecting hard surfaces comprises: a) from 0.0005% to 20% by weight of peracetic acid, b) from 0.001% to 45% by weight of acetic acid, c) from 0.001% to 35% by weight of hydrogen peroxide, d) from 0.0001% to 2% by weight of at least one compound of formula (I) (R1)(R2)(R3)N→O (I) e) if desired, up to 2.5% by weight of at least one nonionic surfactant, and wherein f) the weight ratio between the compound of formula (I) and the peracetic acid is less than or equal to 1, and in that g) the weight ratio between the nonionic surfactant and the peracetic acid is less than or equal to 0.2.Type: GrantFiled: November 20, 2000Date of Patent: September 3, 2002Assignees: Chemoxal SA, Societe d'Exploitation de Produits pour les Industries Chimiques SeppicInventors: Catherine Hamon Godin, Yves Gouges, Daniel Le Rouzic
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Patent number: 6444709Abstract: The invention relates to novel heteroethynylenic compounds having the general formula (I): as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmological complaints in particular), or alternatively in cosmetic compositions.Type: GrantFiled: February 7, 2000Date of Patent: September 3, 2002Assignee: Galderma Research & Development S.N.C.Inventors: Philippe Diaz, Jean-Michel Bernardon
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Publication number: 20020120013Abstract: Novel inhibitors of polyisoprenyl phosphate signaling regulates phopholipase D activity.Type: ApplicationFiled: October 19, 2001Publication date: August 29, 2002Inventor: Charles N. Serhan
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Publication number: 20020058660Abstract: Pesticidal 1,4-diaryl-2,3-difluoro-2-butene compounds of formula I 1Type: ApplicationFiled: September 12, 2001Publication date: May 16, 2002Inventor: Terence James Bentley
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Patent number: 6369048Abstract: Methods and compositions for selectively inactivating viruses in biological compositions, including contacting the composition with an organic solvent and an ethyleneimine oligomer inactivating agent, are disclosed.Type: GrantFiled: January 12, 1998Date of Patent: April 9, 2002Assignee: V.I. Technologies, Inc.Inventors: Edward I. Budowsky, Samuel K. Ackerman, Andrei A. Purmal, Clark M. Edson, Martin D. Williams
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Publication number: 20020037918Abstract: The present invention provides an efficient synthetic strategy for the preparation of analogs that incorporate important structural elements of the marine natural product curacin A, the compositions and various uses of the compositions. The most active of these compounds at nanomolar concentrations inhibit tubulin polymerization, show growth inhibition activity, inhibited colchicines binding to tubulin and block mitotic progression. The compounds of the present invention represent some of the most potent synthetic curacin A analogs synthesized, with an activity profile rivaling that of the natural product despite the simplified structure, greater water solubility, and increased chemical stability.Type: ApplicationFiled: July 19, 2001Publication date: March 28, 2002Inventors: Peter Wipf, Jonathan T. Reeves, Billy W. Day, Raghavan Balachandran
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Publication number: 20020028852Abstract: Compositions and methods for prevention or treatment of disease are provided which comprise analogs of Resveratrol.Type: ApplicationFiled: May 18, 2001Publication date: March 7, 2002Inventors: Geetha Ghai, Kuang Yu Chen, Robert T. Rosen, Mingfu Wang, Nitin Telang, Martin Lipkin, Chi-Tang Ho
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Patent number: 6342536Abstract: A pesticide and a method of using the pesticide to kill invertebrates, especially insects, arachnids and larvae. The method is to prepare a mixture of a carrier with the pesticide and apply the mixture to the insects, arachnids and larvae and their habitat. The pesticide is a neurotransmitter affector utilizing octopamine receptor sites in the insects, arachnids and larvae. The affector agent is a chemical having a six membered carbon ring having substituted thereon at least one oxygenated functional group. The affector agent is a chemical component of a plant essential oil and is naturally occurring. Deposition of the chemicals of the present invention on a surface provides residual toxicity for up to 30 days. Various carriers for the affector agent are disclosed. The chemicals of the present invention deter feeding of insects, arachnids and larvae and also retard growth of the larvae of the insects and arachnids.Type: GrantFiled: December 22, 1999Date of Patent: January 29, 2002Assignee: Ecosmart Technologies IncorporatedInventors: Steven M. Bessette, Myron A. Beigler
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Publication number: 20020006918Abstract: The use of eugenol, alone and in combination with 2-methoxyestradiol (2-ME) in the context of prostate cancer prophylaxes and treatment.Type: ApplicationFiled: February 9, 2001Publication date: January 17, 2002Applicant: Biochemix, Inc.Inventors: Thomas J. Slaga, Addanki P. Kumar, William Alworth
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Patent number: 6288011Abstract: Pesticidal 1,4-diaryl-2,3-difluoro-2-butene compounds having the structural formula I and compositions and methods comprising those compounds for the control of insect and acarid pests.Type: GrantFiled: November 11, 1998Date of Patent: September 11, 2001Assignee: American Cyanamid Co.Inventors: Terence James Bentley, Keith Douglas Barnes
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Patent number: 6239170Abstract: Mammalian hair growth is reduced by applying to the skin a composition including an inhibitor of 5-lipoxygenase.Type: GrantFiled: May 28, 1993Date of Patent: May 29, 2001Inventors: Gurpreet S. Ahluwalia, Douglas Shander
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Patent number: 6183767Abstract: A pesticide and a method of using the pesticide to kill invertebrates, especially insects, arachnids and larvae. The method is to prepare a mixture of a carrier with the pesticide and apply the mixture to the insects, arachnids and larvae and their habitat. The pesticide is a neurotransmitter affector utilizing octopamine receptor sites in the insects, arachnids and larvae. The affector agent is a chemical having a six membered carbon ring having substituted thereon at least one oxygenated functional group. The affector agent is a chemical component of a plant essential oil and is naturally occurring. Deposition of the chemicals of the present invention on a surface provides residual toxicity for up to 30 days. Various carriers for the affector agent are disclosed. The chemicals of the present invention deter feeding of insects, arachnids and larvae and also retard growth of the larvae of the insects and arachnids.Type: GrantFiled: April 8, 1998Date of Patent: February 6, 2001Assignee: Ecosmart Technologies, IncorporatedInventors: Steven M. Bessette, Myron A. Beigler
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Patent number: 6183733Abstract: Compositions and methods for attracting, killing, and/or neutering populations of boll weevils and other insects which spend the winter in areas with thick vegetation are disclosed. With respect to boll weevils, certain plant compounds, when presented along with Grandlure, the synthetic pheromone of the cotton boll weevil (Anthonomus grandis Boh.), increase the capture of boll weevils by as much as 50% as compared to Grandlure alone. The compounds, beta-caryophyllene, eugenol and myrcene, are among those present in leaves in overwintering sites favored by boll weevils. With respect to controlling boll weevil populations, the compounds can be used alone, in combination with Grandlure, and/or in combination with compounds which are toxic to boll weevils or which inhibit their ability to develop normally or reproduce.Type: GrantFiled: April 13, 1999Date of Patent: February 6, 2001Assignee: Cotton IncorporatedInventor: Gerald H. McKibben
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Patent number: 6184255Abstract: The present invention has for its object to provide a medicinal composition comprising coenzyme Q10 as an active ingredient, which composition features an enhanced absorption after oral administration. The present invention is directed to a medicinal composition comprising coenzyme Q10 as an active ingredient with the reduced form of coenzyme Q10 accounting for more than 20 weight % of said coenzyme Q10.Type: GrantFiled: May 26, 1999Date of Patent: February 6, 2001Assignee: Kaneka CorporationInventors: Tatsumasa Mae, Yoshitomo Sakamoto, Souichi Morikawa, Takayoshi Hidaka
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Patent number: 6168808Abstract: Composition in the form of an aqueous solution, useful for disinfecting hard surfaces comprises: a) from 0.0005% to 20% by weight of peracetic acid, b) from 0.001% to 45% by weight of acetic acid, c) from 0.001% to 35% by weight of hydrogen peroxide, d) from 0.0001% to 2% by weight of at least one compound of formula (I) (R1) (R2) (R3)N→O (I) e) if desired, up to 2.5% by weight of at least one nonionic surfactant, and wherein f) the weight ratio between the compound of formula (I) and the peracetic acid is less than or equal to 1, and in that g) the weight ratio between the nonionic surfactant and the peracetic acid is less than or equal to 0.2.Type: GrantFiled: April 24, 1998Date of Patent: January 2, 2001Assignees: Chemoxal SA, Societe d'Exploitation de Produits pour les Industries Chimiques SeppicInventors: Catherine Hamon Godin, Yves Gouges, Daniel Le Rouzic
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Patent number: 6156802Abstract: The present invention has its object to provide an antihypercholesterolemic or antihyperlipidemic agent, hence a therapeutic and prophylactic drug for arteriosclerosis, which is safer and more potent in cholesterol-lowering action than the hitherto-available drugs.Type: GrantFiled: May 27, 1998Date of Patent: December 5, 2000Assignee: Kaneka CorporationInventors: Tatsumasa Mae, Takayoshi Hidaka
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Patent number: 6143311Abstract: The present invention provides novel iodopropargyl derivatives represented by the following formula (1): ##STR1## wherein R.sup.1 is a methoxy group or a cyano group, which have a reduced unpleasant smell and also have a wide antimicrobial spectrum and a high antimicrobial activity. Also, the present invention provides antimicrobial, antifungal and preservative or antimold agents comprising the above derivatives as an active ingredient.Type: GrantFiled: August 26, 1999Date of Patent: November 7, 2000Assignees: Nagase & Company, Ltd., Nagase Chemicals Ltd.Inventors: Yasuo Chikusa, Keita Umetsu, Shigeya Saijo, Masafumi Moriwaki, Toshimasa Ohnishi, Ikuya Tanaka, Yuji Yanagida
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Patent number: 6136865Abstract: A method for reduction of the viral infectiousness of potentially infectious material, such as human or animal body fluids or fractions derived therefrom from which biologically active substances can be isolated, wherein the infectiousness is due to non-lipid-coated viruses characterized in thatsaid potentially infectious material for the isolation of said biologically active substances is treated witha hydrophobic phase which is essentially insoluble in water and is capable of forming a two-phase system with said potentially infectious material, andsaid hydrophobic phase is separated from the potentially infectious material thus treated.Type: GrantFiled: June 7, 1995Date of Patent: October 24, 2000Assignee: Octapharma AGInventors: Lothar Biesert, Horst Schwinn, Wolfgang Marguerre
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Patent number: 6130253Abstract: Pesticides for the extermination of terrestrial arthropods are disclosed which comprise formulations of a combination of terpenes in aqueous solutions which may be used together with citral. No resistance to the formulations of the invention has been seen. When used on the scalp or body for lice infestation no extended dwell time is required. The formulations do not have unpleasant odors. The formulations are directed towards providing topical preparations which may be used on the skin, scalp and hairy body parts of humans and animals, sprays for use directly against terrestrial arthropods, a dipping solution for combs and a laundry additive, amongst others.Type: GrantFiled: August 23, 1999Date of Patent: October 10, 2000Assignee: XiMed Group PLCInventors: Lanny Udell Franklin, Gary David Cunnington, David E. Young
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Patent number: 6127417Abstract: New stable derivatives of ubiquinole are described, having general formula (I), along with processes for their production and their pharmaceutical use, in particular in the treatment of intracellular oxidative stress and diseases involving oxidative stress of this kind.Type: GrantFiled: August 3, 1999Date of Patent: October 3, 2000Assignee: IDI Farmaceutici S.p.A.Inventors: Decimo Guarnieri, Santo Carbone, Siro Passi
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Patent number: 6114384Abstract: A method for controlling insects and arachnids using a composition which is non-toxic to humans. The composition may be a dust, an aerosol or a solvent solution of at least one neurally effective substance. The neurally effective substance has the following general chemical structure, ##STR1## where R.sub.1 is any of the following: CH.sub.2, C.sub.2 H.sub.4, C.sub.3 H.sub.6, C.sub.3 H.sub.4, C.sub.4 H.sub.8 or C.sub.4 H.sub.4 ;where R.sub.2 is any of the following:H, H.sub.2, CH.sub.3, C.sub.2 H.sub.5, C.sub.3 H.sub.7, C.sub.3 H.sub.5, C.sub.4 H.sub.9 or C.sub.4 H.sub.5 ;where R.sub.3 is any of the following:H, H.sub.2 or OCH.sub.3 ;where the six member ring ABCDEF has at least one unsaturated bond therein. The neurally active substances may also be an ester of the hydroxyl group on R.sub.1. Specific active compounds encompass terpineol, phenylethyl alcohol, benzylacetate, benzyl alcohol, eugenol, cinnamic alcohol and mixtures thereof.Type: GrantFiled: June 7, 1996Date of Patent: September 5, 2000Assignee: Ecosmart, Inc.Inventors: Steven M. Bessette, Arthur M. Knight
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Patent number: 6114572Abstract: The present invention provides compounds of the formula ##STR1## wherein X is selected from the group consisting of ##STR2## Y is thio, oxy or a methylene group; Z is hydrogen or --C(O)--(CH.sub.2).sub.m --Q wherein Q is hydrogen or --COOH and m is an integer 1, 2, 3 or 4;R.sub.1 is C.sub.1 -C.sub.6 alkyl; andR.sub.2, R.sub.3 and R.sub.4 are each independently hydrogen or C.sub.1 -C.sub.6 alkyl;or a stereoisomer thereof; useful for the treatment of atherosclerosis and chronic inflammatory disorders; for inhibiting cytokine-induced expression of VCAM-1 and/or ICAM-1; for inhibiting the peroxidation of LDL lipid; for lowering plasma cholesterol; and as anti-oxidant chemical additives useful for preventing oxidative deterioration in organic materials.Type: GrantFiled: November 19, 1997Date of Patent: September 5, 2000Assignee: Hoechst Marion Roussel, Inc.Inventors: Roger A. Parker, Paul S. Wright, Steven J. Busch, Kim S. Chen, Mark T. Yates
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Patent number: 6074634Abstract: The present invention provides an composition for attracting noctuid and/or other lepidopteran species. Liquid and solid formulations are provided, along with methods for their use, for controlling or eliminating noctuid and/or other lepidopteran species, and/or protecting plants susceptible to noctuid and/or other lepidopteran species damage.Type: GrantFiled: October 5, 1998Date of Patent: June 13, 2000Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Juan D. Lopez, Jr., Ted N. Shaver, Kenneth R. Beerwinkle, Peter D. Lingren
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Patent number: 6013260Abstract: An extract composition derived from the peel of a banana and the method for producing the extract composition. An aqueous solvent is combined with the peel of a banana. If the banana is unripe, a base is also added. The mixture is homogenized and allowed to react at least until a black supernatant appears. The entire slurry is filtered. The resulting extract is used alone or combined with a cream or ointment. Medicinal benefits of the extract include relief from pain, swelling, itching, bruising, wrinkles, and sunburn.Type: GrantFiled: January 14, 1999Date of Patent: January 11, 2000Inventor: Bobby Gene Edwards
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Patent number: 6004569Abstract: A pesticide and a method of using the pesticide to kill invertebrates, especially insects, arachnids and larvae. The method is to prepare a mixture of a carrier with the pesticide and apply the mixture to the insects, arachnids and larvae and their habitat. The pesticide is a neurotransmitter affector utilizing octopamine receptor sites in the insects, arachnids and larvae. The affector agent is a chemical having a six membered carbon ring having substituted thereon at least one oxygenated functional group. The affector agent is a chemical component of a plant essential oil and is naturally occurring. Deposition of the chemicals of the present invention on a surface provides residual toxicity for up to 30 days. Various carriers for the affector agent are disclosed. The chemicals of the present invention deter feeding of insects, arachnids and larvae and also retard growth of the larvae of the insects and arachnids.Type: GrantFiled: June 6, 1997Date of Patent: December 21, 1999Assignee: Ecosmart Technologies, Inc.Inventors: Steven M. Bessette, Myron A. Beigler
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Patent number: 5989559Abstract: An extract composition derived from the peel of a banana and the method for producing the extract composition. An aqueous solvent is combined with the peel of a banana. If the banana is unripe, a base is also added. The mixture is homogenized and allowed to react at least until a black supernatant appears. The entire slurry is filtered. The resulting extract is used alone or combined with a cream or ointment. Medicinal benefits of the extract include relief from pain, swelling, itching, bruising, wrinkles, and sunburn.Type: GrantFiled: January 29, 1998Date of Patent: November 23, 1999Assignee: Delft Pharma InternationalInventor: Bobby Gene Edwards
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Patent number: 5972344Abstract: An extract composition derived from the peel of a banana and the method for producing the extract composition. An aqueous solvent is combined with the peel of a banana. If the banana is unripe, a base is also added. The mixture is homogenized and allowed to react at least until a black supernatant appears. The entire slurry is filtered. The resulting extract is used alone or combined with a cream or ointment. Medicinal benefits of the extract include relief from pain, swelling, itching, bruising, wrinkles, and sunburn.Type: GrantFiled: January 14, 1999Date of Patent: October 26, 1999Inventor: Bobby Gene Edwards
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Patent number: 5912273Abstract: A pharmaceutical composition is provided for use in the prevention or treatment of osteoporosis comprising a therapeutically effective amount of a compound of formula (I) ##STR1## wherein R.sub.1 and R.sub.2 are independently H or OH, for the treatment or prevention of osteoporosis and a pharmaceutically acceptable carrier.Type: GrantFiled: September 25, 1997Date of Patent: June 15, 1999Assignee: Orion-Yhtyma OyInventors: Michael Degregorio, Valerie Wiebe, Lauri Kangas, Pirkko Harkonen, Kalervo Vaananen, Aire Laine
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Patent number: 5880162Abstract: A pesticidal compound of formula I: ##STR1## in which formula: either R.sup.1 is hydrogen and R.sup.2 represents a cyclopropyl group or R.sup.1 and R.sup.2 each represent an alkyl group, which alkyl groups may be the same or different;Ar.sub.A represents an optionally substituted phenyl or naphthyl group;Ar.sub.B represents a phenoxy, phenyl, benzyl or benzoyl-substituted phenyl group which is optionally further substituted;the configuration of the groups Ar.sub.A --CR.sup.1 R.sup.2 and --CH.sub.2 Ar.sub.B about the double bond being mutually trans.Preferably Ar.sub.A is a substituted phenyl group; more preferably being substituted at the 4-(para) position by halogen, alkoxy or haloalkyl.Further provided is a process for the preparation of a pesticidal compound of formula I in which a compound comprising a moiety ##STR2## and a compound comprising a moiety Ar.sub.B -- are reacted together forming a link --CH.dbd.C(F)CH.sub.2 -- between ##STR3## and Ar.sub.B in the compound of formula I.Type: GrantFiled: October 21, 1996Date of Patent: March 9, 1999Assignee: British Technology Group, Ltd.Inventors: Bhupinder Pall Singh Khambay, Mu-Guang Liu
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Patent number: 5869506Abstract: The present invention provides a fluoropropene compound represented by Formula I: ##STR1## wherein R.sup.1 represents a C.sub.1 -C.sub.10 alkyl group or other groups, Z represents an oxygen atom or other groups, R.sup.2, R.sup.3, and R.sup.4 each independently represent a C.sub.1 -C.sub.3 alkyl group or other groups, r represents an integer of 0 to 2, and X represents a halogen atom or other groups.Type: GrantFiled: January 30, 1997Date of Patent: February 9, 1999Assignee: Sumitomo Chemical Company, LimitedInventors: Keiichi Izumi, Hiroshi Ikegami, Masaya Suzuki, Noriyasu Sakamoto, Hirotaka Takano
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Patent number: 5861415Abstract: Curcuminoids have been found to have anti-oxidant, anti-inflammatory, antibacterial, antifungal, antiparasitic, anti-mutagen, anticancer and detox properties. The present invention is directed to compositions containing three curcuminoids, i.e. curcumin, demethoxy curcumin and bis demethoxy curcumin, extracted from roots of tumeric. These compositions have been found to have activity in the anti-oxidant mechanisms of prevention and intervention.Type: GrantFiled: October 27, 1997Date of Patent: January 19, 1999Assignee: Sami Chemicals & Extracts, Ltd.Inventors: Muhammed Majeed, Vladimir Badmaev, R. Rajendran
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Patent number: 5859017Abstract: In a method for treating or preventing allergy or allergic disorders an effective amount of a compound that inhibits intracellular generation of phosphatidic acid and diacylglycerol is administered. The intracellular generation of phosphatidic acid and diacylglycerol results from allergen presentation or mast cell/basophil activation.Type: GrantFiled: April 1, 1994Date of Patent: January 12, 1999Assignee: Cell Therapeutics, Inc.Inventors: Elisa Eiseman, Emer Clarke, Jack W. Singer, Stuart L. Bursten
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Patent number: 5840724Abstract: This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.Type: GrantFiled: June 24, 1997Date of Patent: November 24, 1998Assignee: Rhone-Poulenc Rorer LimitedInventors: Garry Fenton, Andrew David Morley, Malcolm Norman Palfreyman, Andrew James Ratcliffe, Brian William Sharp, Keith Alfred James Stuttle, Sukanthini Thurairatnam, Bernard Yvon Jack Vacher
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Patent number: 5750576Abstract: Compounds having formula (I) wherein R.sub.1 and R.sub.2 are independently H or OH, are useful in the treatment and prevention of osteoporosis. The compounds of formula (I) are devoid of significant antiestrogenic and estrogenic activity.Type: GrantFiled: April 1, 1997Date of Patent: May 12, 1998Assignee: Orion-Yhtyma OyInventors: Michael DeGregorio, Valerie Wiebe, Lauri Kangas, Pirkko Harkonen, Kalervo Vaananen, Aire Laine
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Patent number: 5679696Abstract: This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.Type: GrantFiled: June 7, 1995Date of Patent: October 21, 1997Assignee: Rhone-Poulenc Rorer LimitedInventors: Garry Fenton, Andrew David Morley, Malcolm Norman Palfreyman, Andrew James Ratcliffe, Brian William Sharp, Keith Alfred James Stuttle, Sukanthini Thurairatnam, Bernard Yvon Jack Vacher
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Patent number: 5629340Abstract: An angiogenesis inhibitor comprising, as an active agent, Compound (I) represented by the formula below: ##STR1## where R.sub.1 is a lower alkyl group, an alkoxycarbonyl group or a carboxyl group; andR.sub.2, R.sub.3 and R.sub.4 maybe the same or different and represent a hydrogen atom, a hydroxyl group, a methoxy group or an acetoxy group.This compound has a remarkable angiogenesis inhibition activity, and an angiogenesis inhibitor useful for treatment of various diseases are provided.Type: GrantFiled: July 10, 1995Date of Patent: May 13, 1997Assignee: Tsumura & Co.Inventors: Michihiko Kuwano, Mayumi Ono, Mika Kusano, Junko Watanabe, Masakazu Takeda
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Patent number: 5571794Abstract: A cosmetic treatment for inducing upper and lower lip augmentation in humans, wherein an active ingredient encouraging vasodilatation, preferably an ultra highly diluted homeopathic, ultra highly diluted element, local irritant or direct local vasodilator or a combination of two or more is administered by topical application or sublingually or gum by chewing. The vasodilators singly or in combinations of preferably ultra highly diluted elements, homeopathics, local irritant or vasodilators are diluted to preferably ten to fifteen percent for topical administration in a cosmetic cream or cosmetic gel or oral sublingual drops diluted in a 2% alcohol base or a five percent fructose-coated chewing gum. The treatment results in a significant non-invasive augmentation of both the upper and lower lip that onsets within a few moments and is effective for a duration on an average of four and one half hours.Type: GrantFiled: June 22, 1995Date of Patent: November 5, 1996Inventor: Bruce M. Frome
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Patent number: 5565191Abstract: Stilbene derivatives of formula (I) ##STR1## wherein A, R.sub.1 and R.sub.2 are as defined in the following, are useful for the protection against UV radiation.Type: GrantFiled: December 13, 1994Date of Patent: October 15, 1996Assignee: 3V Inc.Inventor: Giuseppe Raspanti
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Patent number: 5563134Abstract: The invention concerns pharmaceutical compositions comprising clozapine and a radical scavenger.Type: GrantFiled: July 2, 1993Date of Patent: October 8, 1996Assignee: Sandoz Ltd.Inventors: Volker Fischer, Ronald P. Mason
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Patent number: 5559133Abstract: A compound represented by formula I, Ar.sub.1 --O--M--O--Ar.sub.2, wherein Ar.sub.1 and Ar.sub.2 are independently substituted phenyl or substituted pyridinyl, the substituents on said phenyl or pyridinyl being independently selected from one, two or three of (C.sub.1 -C.sub.10) alkyl, (C.sub.1 -C.sub.10) alkoxy, halogen, carbamyl, (C.sub.1 -C.sub.10) alkoxycarbonyl, oxazoyl, and (C.sub.1 -C.sub.10) alkyl substituted by halogen, (C.sub.1 -C.sub.10) alkoxy, hydroxy, or (C.sub.1 -C.sub.10) alkoxycarbonyl; ##STR1## O is oxygen; R' is (C.sub.1 -C.sub.3 alkyl or H; A is oxygen or sulfur; Q is selected from hydrogen, halogen, nitro, (C.sub.1 -C.sub.6) alkyl, (C.sub.1 C.sub.6) perhaloalkyl, (C.sub.1 -C.sub.6) alkylthio (C.sub.1 -C.sub.Type: GrantFiled: December 16, 1993Date of Patent: September 24, 1996Assignee: Schering CorporationInventors: Viyyoor M. Girijavallabhan, Ashit K. Ganguly, Richard W. Versace, Anil K. Saksena, Patrick A. Pinto
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Patent number: 5530015Abstract: There is disclosed a dihalopropene compound of the formula I: ##STR1## wherein l is an integer of 1 to 5; m is an integer of 1 to 4; R.sup.1 's and R.sup.2 's are the same or different and are independently halogen or various other groups; D is oxygen; X's are the same or different and are independently chlorine or bromine; Y is oxygen; Z, P and Q are the same or different and are independently nitrogen or CH, provided that P and Q are not simultaneously nitrogen, and when Y is sulfur, Z is CH. Also disclosed is an insecticide/acaricide comprising the dihalopropene compound as an active ingredient. The dihalopropene compound exhibits excellent insecticidal/acaricidal action. Further disclosed is an intermediate compound for use in the production of the dihalopropene compound.Type: GrantFiled: October 19, 1994Date of Patent: June 25, 1996Assignee: Sumitomo Chemical Company, LimitedInventors: Noriyasu Sakamoto, Masaya Suzuki, Toshio Nagatomi, Kazunori Tsushima, Kimitoshi Umeda
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Patent number: 5492687Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodophenoxy alkylene ethers and pharmaceutically acceptable clays in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.Type: GrantFiled: May 3, 1994Date of Patent: February 20, 1996Assignee: Sterling Winthrop Inc.Inventors: Stephen B. Ruddy, Gregory L. McIntire, Mary E. Roberts, Edward R. Bacon
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Patent number: RE37087Abstract: There are provided new alkane and alkoxyalkane derivatives of the general formula I in which R1, R2, R3, R4 and A have the meanings given in the description, processes for their preparation and insecticidal and acaricidal compositions containing these compounds.Type: GrantFiled: June 20, 1991Date of Patent: March 6, 2001Assignee: Schering AktiengesellschaftInventors: Helga Franke, Heinrich Franke, Hans-Rudolf Kruger, Hartmut Joppien, Dietrich Baumert, David Giles