Polyvinyl Alcohol Patents (Class 514/772.2)
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Publication number: 20120309851Abstract: The present invention relates to methods for removing residual surface material from porous polymerized particle surfaces. The particles thus produced have an increase in surface porosity and uniformity in a variety of applications. Desirably, substantially the entire surface communicates with the interior of the particles. Also provided are the particles produced by such methods, further modifications of such particles, and methods for using the particles in a variety of applications. All described methods, compositions, and articles of manufacture are within the scope of the invention.Type: ApplicationFiled: May 4, 2010Publication date: December 6, 2012Inventors: Nai-Hong Li, Yuchiong Hsuanyu, James R. Benson, Marc Freed
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Publication number: 20120294926Abstract: The present invention is drawn to adhesive formulations and methods of drug delivery. The formulation can include a drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system including at least two volatile solvents, and a non-volatile solvent system including at least one non-volatile solvent, wherein at least one non-volatile solvent is capable of facilitating the delivery of the drug at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.Type: ApplicationFiled: August 3, 2012Publication date: November 22, 2012Inventors: Jie Zhang, Kevin S. Warner, Sanjay Sharma
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Publication number: 20120295988Abstract: A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.Type: ApplicationFiled: July 31, 2012Publication date: November 22, 2012Inventors: Walter C. Babcock, William J. Curatolo, Dwayne T. Friesen, Rodney J. Ketner, Julian B. Lo, James A. S. Nightingale, Ravi M. Shanker, James B. West
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Publication number: 20120288562Abstract: The present invention relates to new acid resistant hard pharmaceutical capsules, a process for their manufacture and use of such capsules particularly but not exclusively for oral administration of pharmaceuticals, veterinary products, food and dietary supplements to humans or animals. The capsules of the invention are obtained by aqueous compositions comprising a water soluble film forming polymer and gellan gum in a mutual weight ratio of 4 to 15 weight parts of gellan gum for 100 weight parts of film forming polymer.Type: ApplicationFiled: September 14, 2010Publication date: November 15, 2012Inventors: Dominique Nicolas Cade, Xiongwei David He
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Publication number: 20120288545Abstract: Compositions suitable for use as skin care products (e.g., skin cream) are disclosed. Methods of making and using compositions suitable for use as skin care products are also disclosed.Type: ApplicationFiled: December 14, 2010Publication date: November 15, 2012Inventors: Demetrius Michos, James Neil Pryor
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Publication number: 20120270955Abstract: An ophthalmic composition is disclosed having a viscosity enhancement system comprised of two different viscosity enhancing agents. The aqueous composition contains a first viscosity enhancing agent that provides enhanced viscosity upon dispensing of the composition to the eye and a second viscosity agent that increases viscosity (e.g., gels or partially gels) after dispensing of the composition to the eye to provide extended viscosity enhancement of the composition.Type: ApplicationFiled: April 19, 2012Publication date: October 25, 2012Inventors: Masood A. Chowhan, Malay Ghosh
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Publication number: 20120269908Abstract: The present invention relates to a carrier in oil-in-water emulsion form, containing a very small amount of a surface-active agent so that the emulsion is stable, well-tolerated, and nonirritating. The present invention also relates to a method for preparing a carrier according to the invention and to the use of such a carrier as a base for compositions to be applied onto sensitive human or animal body tissue, particularly in dermatological or dermocosmetic compositions.Type: ApplicationFiled: November 27, 2009Publication date: October 25, 2012Applicant: OCTALIA TECHNOLOGIESInventors: Christian Sarrazin, Marina Do, Michele Boix
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Publication number: 20120244197Abstract: Film-like pharmaceutical dosage forms, comprising, as film formers, amphiphilic copolymers and one or more active substances.Type: ApplicationFiled: November 12, 2010Publication date: September 27, 2012Applicant: BASF SEInventors: Dejan Djuric, Karl Kolter, Michael Gerrit Herting
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Publication number: 20120245032Abstract: An aqueous composition is provided having a pH of from about 2.0 to about 12.8 and comprising boron or persulfate ion-crosslinked polyvinyl alcohol microcapsules. A method of delivering an agriculture active to a substrate is further provided comprising applying to the substrate an aqueous composition comprised of agriculture active containing, boron or persulfate ion-crosslinked, polyvinyl alcohol microcapsules, as well as a method of treating a substrate to protect from pests or promote crop growth comprising applying to the substrate an aqueous treating composition comprised of agriculture active containing, boron or persulfate ion-crosslinked, polyvinyl alcohol microcapsules.Type: ApplicationFiled: June 7, 2012Publication date: September 27, 2012Applicant: Appleton Papers Inc.Inventor: Robert Stanley Bobnock
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Publication number: 20120237576Abstract: Filaments that contain a filament-forming material and an additive, nonwoven webs, and methods for making such filaments are provided.Type: ApplicationFiled: September 12, 2011Publication date: September 20, 2012Inventors: Gregory Charles Gordon, Robert Wayne Glenn, JR., Mark Robert Sivk, Mark Ryan Richards, Stephen Wayne Heinzman, Michael David James, Geoffrey William Reynolds, Paul Dennis Trokhan, Paul Thomas Weisman, Alyssandrea Hope Hamad-Ebrahimpour, Frank William Denome, Stephen Joseph Hodson
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Publication number: 20120202894Abstract: Dosage forms comprising formulations of sparingly water-soluble active ingredients in a polymer matrix composed of amphiphilic polyether copolymers and of at least one hydrophilic polymer, in which the sparingly water-soluble active ingredient is present in amorphous form in the polymer matrix.Type: ApplicationFiled: September 17, 2010Publication date: August 9, 2012Applicant: BASF SEInventors: Karl Kolter, Dejan Djuric, Stefan Fischer
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Patent number: 8202548Abstract: A method of making a composition having the property of being able to store chlorine dioxide includes mixing an aqueous chlorine dioxide solution with a superabsorbent, water-soluble polymer that is substantially unreactive with chlorine dioxide and permitting a mixture formed thereby to form one of a gel and a solid composition. A method of delivering chlorine dioxide includes providing a gel or solid composition as described and degelling the gel or dissolving the solid composition to dispense the chlorine dioxide therefrom. A method of disinfecting a target such as water, wastewater, or a surface comprises delivering chlorine dioxide as above and permitting the polymer to precipitate out of the mixture. Aqueous chlorine dioxide is then recovered and applied to the target.Type: GrantFiled: July 19, 2007Date of Patent: June 19, 2012Assignee: Dharma IP, LLCInventors: Sunggyu Lee, Patricia Roberts
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Publication number: 20120114705Abstract: A composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity is disclosed. The carrier comprises water-soluble polymers in combination with certain ingredients and provides a therapeutic and/or cosmetic effect. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.Type: ApplicationFiled: November 9, 2011Publication date: May 10, 2012Inventors: Horst Georg ZERBE, Jian-Hwa Guo, Anthony Serino
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Patent number: 8163298Abstract: A personal care composition in the form of an aqueous gel may comprise an alpha-hydroxy acid, wherein the pH of the composition is less than about 4.5. The personal care composition comprises a gelling agent and an aqueous solvent. The personal care composition further comprises particulates and an effective amount of suspension agent to suspend the particulates. The personal care composition exhibits a consumer desired viscosity and translucency.Type: GrantFiled: October 28, 2009Date of Patent: April 24, 2012Assignee: The Procter & Gamble CompanyInventors: Susan Adair Griffiths-Brophy, Dennis Eugene Kuhlman
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Publication number: 20120087859Abstract: The present invention relates to a biopolymer-modified nanocarrier in which chitosan is bound to a water-soluble biocompatible polymer that has been crosslinked via a photo-crosslinkable functional group; wherein the chitosan-modified nanocarrier has a diameter which changes in accordance with changes in temperature, has enhanced skin permeability or cellular uptake and selective delivery to cancer tissue as compared with a bare nanocarrier to which chitosan has not been bound, and exhibits characteristics that are advantageous in photothermal therapy. The chitosan-modified nanocarrier of the present invention exhibits highly superior efficacy as a transdermal carrier, since the skin permeability is enhanced to a significant level as compared with a bare nanocarrier that has no chitosan.Type: ApplicationFiled: January 21, 2011Publication date: April 12, 2012Applicant: GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Gi Yoong Tae, Won II Choi, Young Ha Kim, Ja-Young Kim, Jong Hyun Lee
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Publication number: 20120058166Abstract: Filaments that contain a filament-forming material and an additive, nonwoven webs, and methods for making such filaments are provided.Type: ApplicationFiled: September 12, 2011Publication date: March 8, 2012Inventors: Robert Wayne Glenn, JR., Gregory Charles Gordon, Mark Robert Sivik, Mark Ryan Richards, Stephen Wayne Heinzman, Michael David James, Geoffrey William Reynolds, Paul Dennis Trokhan, Paul Thomas Weisman, Alyssandrea Hope Hamad-Ebrahimpour, Frank William Denome, Stephen Joseph Hodson
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Publication number: 20120052036Abstract: Filaments that contain a filament-forming material and an additive, nonwoven webs, and methods for making such filaments are provided.Type: ApplicationFiled: September 12, 2011Publication date: March 1, 2012Inventors: Robert Wayne Glenn, JR., Gregory Charles Gordon, Mark Robert Sivik, Mark Ryan Richards, Stephen Wayne Heinzman, Michael David James, Geoffrey William Reynolds, Paul Dennis Trokhan, Paul Thomas Weisman, Alyssandrea Hope Hamad-Ebrahimpour, Frank William Denome, Stephen Joseph Hodson
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Publication number: 20120052037Abstract: A web material containing one or more active agents and methods for making same are provided.Type: ApplicationFiled: September 12, 2011Publication date: March 1, 2012Inventors: Mark Robert Sivik, Gregory Charles Gordon, Frank William Denome, Alyssandrea Hope Hamad-Ebrahimpour, Stephen Joseph Hodson, Brian Patrick Croll, John Gerhard Michael, Andreas Josef Dreher, Paul Dennis Trokhan
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Publication number: 20120052041Abstract: The invention is directed to modified polymers with increased drug-loading including compounds of formula (I): wherein Z is a poly(lactic-co-glycolic acid) (PLGA) polymer having molecular weight from 1-15 kDa and where the ratio of lactide to glycolide in the PLGA polymer is from 1:10 to 10:1; formula (II) R1 are independently H, R2, OH, O-alkyl, —O—R2, NH—R2, -linker-R2, or -and R2 are independently one or more therapeutic agents. The invention is also directed to nanoparticle drug delivery systems including a PLGA-b-PEG block copolymer; and a stabilizer and to drug delivery systems including PLGA-b-PEG block copolymer polyvinyl alcohol (PVA) nanoparticle; and the modified polymer substantially as described herein.Type: ApplicationFiled: February 4, 2010Publication date: March 1, 2012Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Sudipta Basu, Rania Harfouche, Shivani Soni, Shiladitya Sengupta
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Patent number: 8097277Abstract: The present invention provides dynamic charge state cationic polymers that are useful for delivery of anionic molecules. The dynamic charge state cationic polymers are designed to have cationic charge densities that decrease by removal of removable functional groups from the polymers. The present invention also provides interpolyelectrolyte complexes containing the polymers complexed to a polyanion. Methods for using the interpolyelectrolyte complexes to deliver anionic compounds are also provided.Type: GrantFiled: November 19, 2010Date of Patent: January 17, 2012Assignee: Wisconsin Alumni Research FoundationInventors: David M. Lynn, Adam D. Miller
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Publication number: 20120003176Abstract: A hydrogel composition is formed from a natural polymer derivative having a plurality of cross-linkable units depending therefrom, and a synthetic polymer derivative having a plurality of cross-linkable units depending therefrom, said natural and synthetic polymer derivatives having hydrolysable units disposed between the polymer backbone of said derivative and at least some of said cross-linkable units. The use of a combination of natural and synthetic polymers provides for biodegradability of the hydrogel, along with mechanical properties such as strength and elasticity.Type: ApplicationFiled: June 30, 2011Publication date: January 5, 2012Applicant: Zimmer Orthobiologics, Inc.Inventors: Xiao Huang, Jian Q. Yao, Jizong Gao, Victor Zaporojan, Joe Zhe Guo
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Patent number: 8088417Abstract: A method of making a composition having the property of being able to store chlorine dioxide includes mixing an aqueous chlorine dioxide solution with a superabsorbent, water-soluble polymer that is substantially unreactive with chlorine dioxide and permitting a mixture formed thereby to form one of a gel and a solid composition. A method of delivering chlorine dioxide includes providing a gel or solid composition as described and degelling the gel or dissolving the solid composition to dispense the chlorine dioxide therefrom. A method of disinfecting a target such as water, wastewater, or a surface comprises delivering chlorine dioxide as above and permitting the polymer to precipitate out of the mixture. Aqueous chlorine dioxide is then recovered and applied to the target.Type: GrantFiled: May 15, 2007Date of Patent: January 3, 2012Assignee: Dharma IP, LLCInventors: Sunggyu Lee, Patricia Roberts
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Patent number: 8071076Abstract: An oral lubricant having usefulness for alleviating the symptoms of dry mouth and preventing accumulation of dental stains based on a polyvinyl alcohol polymer containing composition in an orally acceptable carrier or vehicle. The invention relates generally to an oral composition having a function in lubricating the mouth and preventing the formation of stains on the surfaces of the teeth. The active ingredients of the composition are a polyvinyl alcohol, a metal chelating agent, lipophilic vitamin, surface active material and a phenolic anti microbial agent with anti-inflammatory properties.Type: GrantFiled: November 21, 2002Date of Patent: December 6, 2011Assignee: Oral Health Clinical Services LLCInventor: Salim A. Nathoo
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Publication number: 20110257253Abstract: Provided is a method for preparing a poorly water-soluble drug-containing polymeric micellar nanoparticle composition, which includes: dissolving a poorly water-soluble drug, a salt of polylactic acid or polylactic acid derivative, whose carboxylic acid end is bound to an alkali metal ion, and an amphiphilic block copolymer into an organic solvent; and adding an aqueous solution to the resultant mixture in the organic solvent to form micelles, wherein the method requires no separate operation to remove the organic solvent prior to the formation of micelles. The method for preparing a poorly water-soluble drug-containing polymeric micellar nanoparticle composition is simple, reduces the processing time, and is amenable to mass production.Type: ApplicationFiled: June 29, 2009Publication date: October 20, 2011Applicant: SAMYANG CORPORATIONInventors: Min Hyo Seo, Sa Won Lee
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Publication number: 20110251265Abstract: The present invention relates to polyamine-containing polymers and methods of their synthesis and use. The polymer may be hydroxyethylcellulose, dextran, poly(vinyl alcohol) or poly(methyl acrylate).Type: ApplicationFiled: April 1, 2011Publication date: October 13, 2011Inventors: Hasan Uludag, Robert W. Jost, Mehmet Yaman Boluk
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Patent number: 8008355Abstract: The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation.Type: GrantFiled: June 17, 2008Date of Patent: August 30, 2011Assignee: Roche Madison Inc.Inventors: David B. Rozema, Darren H. Wakefield, Sean D. Monahan, Lori Higgs, Jon A. Wolff, James E. Hagstrom
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Publication number: 20110142888Abstract: Film coating compositions based on a co-processed mixture of a polyvinyl alcohol-polyether graft polymer and polyvinyl alcohol (component A), a N-vinylpyrrolidone-vinyl acetate copolymer (component B) and pigments (component C).Type: ApplicationFiled: December 16, 2010Publication date: June 16, 2011Applicant: BASF SEInventors: Thorsten Cech, Verena Geiselhart, Thorsten Agnese
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Publication number: 20110129510Abstract: The invention relates to a fibrous surface structure containing active ingredients with an adjustable active ingredient release profile, comprising a fibrous, polymeric, soluble and/or degradable active ingredient substrate and at least one active ingredient that is associated with the substrate and can be released by the fibrous surface structure; to formulations containing active ingredients, comprising such fibrous surface structures; to the use of fibrous surface structures containing active ingredients according to the invention for producing formulations containing active ingredients; and to a method for producing fibrous surface structures according to the invention.Type: ApplicationFiled: August 7, 2009Publication date: June 2, 2011Applicant: BASF SEInventors: Burghard Liebmann, Evgueni Klimov
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Publication number: 20110059175Abstract: The present invention relates generally to use of a polyvinyl alcohol-polyethylene glycol graft copolymer (PVA-PEG graft co-polymer), such as Kollicoat IR, in the formulation of solid dispersions of low aqueous solubility and dissolution rate bioactive compound and, more particularly to a system and method for improving the solubility and dissolution rate of such low aqueous solubility and dissolution rate bioactive compound, in particular the drug of low aqueous solubility, such as a BCS Class II or Class IV drug compounds.Type: ApplicationFiled: April 10, 2007Publication date: March 10, 2011Applicant: K.U.LEUVEN RESEARCH AND DEVELOPMENTInventors: Sandrien Janssens, Guy Van Den Mooter
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Patent number: 7883720Abstract: The present invention provides dynamic charge state cationic polymers that are useful for delivery of anionic molecules. The dynamic charge state cationic polymers are designed to have cationic charge densities that decrease by removal of removable functional groups from the polymers. The present invention also provides interpolyelectrolyte complexes containing the polymers complexed to a polyanion. Methods for using the interpolyelectrolyte complexes to deliver anionic compounds are also provided.Type: GrantFiled: July 7, 2004Date of Patent: February 8, 2011Assignee: Wisconsin Alumni Research FoundationInventors: David M. Lynn, Adam D. Miller
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Publication number: 20110027332Abstract: A firm but pliable medical device for use as a bone graft substitute or bone graft extender retains its shape without the requirement of a containment device, such as a syringe. Because the device is solid, it is easy to locate or position in-vivo and, in the moist environment of the body, it will hold its shape well, for an extended time. Because the lyophilized pliable medical device is porous, it adsorbs blood and other beneficial cells containing body fluids, such as bone marrow, contributing to its superior bone repair efficacy in comparison to an analogous putty that has not been lyophilized. In addition these lyophilized pliable medical devices are easier to terminally steam sterilize than the analogous putty because there is no moisture present to boil and “blow-out” of the containment device (syringe). The glycerin that is present in the formulation lends pliability but has a low vapor pressure.Type: ApplicationFiled: December 15, 2006Publication date: February 3, 2011Applicant: CERAPEDICS, INC.Inventors: James J. Benedict, Greg Allen Brewster, Donald Barclay Greeman
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Publication number: 20100303920Abstract: The invention relates to a film coating composition for use in coating a pharmaceutical formulation, said composition comprising a dispersion which comprises an acrylic polymer; a surfactant containing repeating ethoxy groups; a water-containing liquid; and a polyvinyl alcohol-polyethylene glycol graft copolymer.Type: ApplicationFiled: November 17, 2009Publication date: December 2, 2010Inventor: Johan Hjartstam
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Publication number: 20100286205Abstract: A gel formulation for use in filling a wound cavity and delivering active ingredient thereto, having a pH range of 6.5 to 7.5, low bioadhesive strength and cohesive integrity and being a PVA borate gel including an active ingredient and a modulator to bind borate and/or PVA in aqueous solution through a mono-diol or di-diol formation and reduces the pH of PVA-borate hydrogels. A suitable modulator is a sugar alcohol such as mannitol and the active ingredient, a medicament suitable for topical application such as a local anaesthetic and/or an antibiotic.Type: ApplicationFiled: September 16, 2008Publication date: November 11, 2010Inventors: Paul Anthony McCarron, Mark Godfrey Jenkins, Ryan Gerald Loughlin
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Publication number: 20100266657Abstract: A drug-eluting device comprising a drug-eluting matrix containing at least one elutable drug, a method of manufacturing a preformed drug-eluting device, and an implant kit comprising the same.Type: ApplicationFiled: October 30, 2009Publication date: October 21, 2010Applicant: Warsaw Orthopedic, Inc.Inventors: Jusong Xia, Hai H. Trieu, William F. McKay, Newton H. Metcalf, JR., Nikolas F. Kerr, Drew Amery
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Publication number: 20100144900Abstract: The Invention relates to a stereo photo hydrogel formed by stereo complexed and photo cross-linked polymers, which polymers comprise at least two types of polymers having at least one hydrophilic component, at least one hydrophobic mutually stereo complexing component, and at least one of the types comprises at least one photo cross-linkable component, to a process of making stereo photo hydrogel comprising the steps of a. providing a mixture of at least two types of polymers having at least one hydrophilic component, at least one hydrophobic mutually stereo complexing component and at least one of the types comprises at least one photo cross-linkable component; b. stereo complexing the two types of polymers, thereby forming a stereo complexed hydrogel; and c. photo cross-linking the stereo complexed hydrogel using visible or UV irradiation, thereby forming the stereo photo hydrogel, to such polymers for use in such hydrogel, and to a pharmaceutical kit comprising same.Type: ApplicationFiled: March 20, 2007Publication date: June 10, 2010Inventors: Christine Hiemstra, Zhiyuan Zhong, Jan Feijen
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Publication number: 20100112043Abstract: An object of the present invention is to provide a liposome which is excellent in intrapulmonary delivery controllability of drugs or genes and is suited for pulmonary administration. By modifying the surface of a liposome using a terminal hydrophobized polyvinyl alcohol and/or chitosan, retention of drugs or genes encapsulated in the liposome on the surface of lung tissue and transfer of drugs or genes into lung tissue can be properly modulated, and thus in vivo behavior can be controlled.Type: ApplicationFiled: March 28, 2008Publication date: May 6, 2010Inventors: Hirofumi Takeuchi, Koji Nakano, Hidekazu Toyobuku
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Patent number: 7704518Abstract: A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.Type: GrantFiled: May 9, 2006Date of Patent: April 27, 2010Assignee: Foamix, Ltd.Inventors: Dov Tamarkin, Doron Friedman, Meir Eini, Alex Besonov
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Patent number: 7655702Abstract: A method of lowering the surface tension or the interface tension of water in cosmetic compositions comprising at least one cosmetic or dermatological adjuvant, the method comprising adding a polymer comprising water-soluble units and units with an LCST, wherein the LCST units an have in water a demixing temperature of from 5 to 40° C. for a concentration of 1% by mass is used, the polymer being present in a concentration such that the gel point of the aqueous phase is from 5 to 40° C., to ensure the stability of the dispersions at temperatures from 4° C. to 50° C.Type: GrantFiled: January 11, 2002Date of Patent: February 2, 2010Assignee: L'OrealInventor: Florence L'Alloret
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Publication number: 20090311325Abstract: The present invention relates generally to use of a polyvinyl alcohol-polyethylene glycol graft copolymer (PVA-PEG graft co-polymer), such as Kollicoat IR, in the formulation of solid dispersions of low aqueous solubility and dissolution rate bioactive compound and, more particularly to a system and method for improving the solubility and dissolution rate of such low aqueous solubility and dissolution rate bioactive compound, in particular the drug of low aqueous solubility, such as a BCS Class II or Class IV drug compounds.Type: ApplicationFiled: April 10, 2007Publication date: December 17, 2009Applicant: K.U.LEUVEN RESEARCH AND DEVELOPMENTInventors: Sandrien Janssens, Guy Van Den Mooter
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Patent number: 7619009Abstract: In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex.Type: GrantFiled: August 7, 2006Date of Patent: November 17, 2009Assignee: Cambridge Polymer Group, Inc.Inventors: Jeffrey W. Ruberti, Gavin J. C. Braithwaite
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Publication number: 20090274762Abstract: A pharmaceutical product comprising lyophilised polymer matrix including a biologically active compound, of particular utility for embolisation, having improved rehydration properties is packaged in an airtight package under vacuum.Type: ApplicationFiled: June 22, 2007Publication date: November 5, 2009Applicant: BIOCOMPATIBLES UK LIMITEDInventors: Sean Willis, Rosemary Palmer
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Patent number: 7612115Abstract: The present invention has an object to provide an antibacterial aqueous pharmaceutical composition and an aqueous pharmaceutical composition which have a sufficiently low gelation temperature even when new quinolone antibacterial agents such as ofloxacin as the active ingredient and can be retained at the administration site for a long time by virtue of rapid viscosity increase after administration in spite of their being liquid at administration and thereby attain high availability of pharmaceutical agent. The present invention relates to an antibacterial aqueous pharmaceutical composition which comprises: 2.8 to 4 w/v % of methylcellulose, the 2 w/v % aqueous solution of which has a viscosity of 12 mPa·s or below at 20° C.; 1.5 to 2.3 w/v % of citric acid; 2 to 4 w/v % of polyethylene glycol; and 0.1 to 0.5 w/v % of ofloxacin.Type: GrantFiled: March 13, 2006Date of Patent: November 3, 2009Assignee: Wakamoto Pharmaceutical Co., Ltd.Inventors: Hidekazu Suzuki, Takahiro Wada, Masanobu Kirita, Masanobu Takeuchi
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Publication number: 20090264538Abstract: Compositions for coating biological and non-biological surfaces, which minimize or prevent cell-cell contact and tissue adhesion, and methods of preparation and use thereof are disclosed. Embodiments include polyethylene glycol/polylysine (PEG/PLL) block or comb-type copolymers with high molecular weight PLL (greater than 1000, more preferably greater than 100,000); PEG/PLL copolymers in which the PLL is a dendrimer which is attached to one end of the PEG; and multilayer compositions including alternating layers of polycationic and polyanionic materials. The multi-layer polymeric material is formed by the ionic interactions of a polycation and a polyanion. The molecular weights of the individual materials are selected such that the PEG portion of the copolymer inhibits cellular interactions, and the PLL portion adheres well to tissues.Type: ApplicationFiled: October 29, 2007Publication date: October 22, 2009Inventors: Jeffrey A. Hubbell, Donald L. Elbert, Curtis B. Herbert
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Publication number: 20090238858Abstract: Degradable polymeric compositions containing water-insoluble drugs blended with copolymers of biocompatible diphenol compound monomer units with pendant carboxylic acid groups polymerized with biocompatible diphenol com-pound monomer units with pendant carboxylic acid ester groups and poly(alkylene oxide) blocks, wherein the molar fraction in the copolymer of biocompatible diphenol compound monomer units with pendant carboxylic acid groups and poly(alkylene oxide) blocks relative to the weight percentage of the drug in the composition is effective to provide pseudo-zero order release of the drug from the composition during the sustained-release phase of drug delivery under physiological conditions. Ocular treatment methods and manufacturing methods are also disclosed.Type: ApplicationFiled: February 20, 2009Publication date: September 24, 2009Applicant: Rutgers, The State University of New JerseyInventors: Joachim B. Kohn, Isaac John Khan, Carmine P. Iovine
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Patent number: 7560493Abstract: The invention relates to a composition for topical use containing, in a physiologically acceptable medium having an aqueous phase, at least one oxidation-sensitive hydrophilic active principle and at least one non-crosslinked N-vinylimidazole polymer or copolymer, the active principle and the said polymer or copolymer both being in the aqueous phase.Type: GrantFiled: November 27, 2002Date of Patent: July 14, 2009Assignee: L'OrealInventors: Bruno Biatry, Eric Lheureux
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Publication number: 20090171264Abstract: Provided are orthopedic implants and scaffolds comprising poly(vinyl alcohol) which has a degree of hydrolysis of at least 90% and a weight average molecular weight of at least 50,000. Also provided are methods for making same.Type: ApplicationFiled: December 18, 2008Publication date: July 2, 2009Applicant: DePuy ProductsInventors: Richard King, Mark Hanes
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Patent number: 7550444Abstract: The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity. In some aspects, the biocompatible coatings of the invention are able to release a bioactive agent. The coatings can be formed using biostable or biodegradable polymeric material and photoreactive groups. The invention also provides methods for improving the quality of bioactive agent-containing coatings by performing pre-irradiation of biocompatible coating compositions.Type: GrantFiled: March 25, 2005Date of Patent: June 23, 2009Assignee: SurModics, Inc.Inventors: Sean M. Stucke, Ralph A. Chappa, Joseph A. Chinn, Aron B. Anderson
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Publication number: 20090060975Abstract: Methods and systems for delivering biological products such as bone marrow aspirate (BMA) to different surgical sites during surgery (for example, arthroscopic surgery). The biological product is encapsulated or contained within a containment system comprising a carrier such as collagen carrier. The containment system may be formed of water soluble polymers, either natural, synthetic or semisynthetic, provided into films that may be made or molded into various shapes and sizes, and that may be manipulated to confer specific properties (such as solubility or degradation rates according to a specific environment, for example) of such films. The water soluble films may be processed into capsules, packets or other containers.Type: ApplicationFiled: August 26, 2008Publication date: March 5, 2009Inventors: J. Maxwell Teets, Christopher Bare, Tara L. Schaneville
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Patent number: 7485670Abstract: In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex.Type: GrantFiled: February 4, 2004Date of Patent: February 3, 2009Assignee: Cambridge Polymer Group, Inc.Inventors: Jeffrey W. Ruberti, Gavin J. C. Braithwaite
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Patent number: RE41279Abstract: The mastitis control teat dip composition having a visible indicator aspect of the invention provides a softening, soothing, smoothing, relaxing property, a rapid initial kill, a useful highly pseudoplastic rheology, a barrier/film-forming capacity, a unique antimicrobial composition that is stable over an extended period of time, and unexpected long term microbial control when compared to the prior art materials disclosed in patents and used in the marketplace. The indicator aspect provides ease of visually detecting the material on the animal skin and can indicate efficacy of the material. The compositions of the invention are made by combining an aqueous liquid composition containing the visual indicator combined with the organic components which can be combined with a simple aqueous solution of a salt of chlorous acid, preferably an alkali metal chlorite.Type: GrantFiled: March 2, 2006Date of Patent: April 27, 2010Assignee: Ecolab Inc.Inventors: David D. McSherry, Francis L. Richter