Natural Gum Or Resin Patents (Class 514/782)
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Patent number: 6372255Abstract: A multi-layer tablet for the instant and prolonged release of active substances comprises at least two layers where the first outer layer comprises a mixture of excipients and an active substance, allowing for the immediate release of the active substance within the first layer, and a second layer, arranged in contact with the first layer. The second layer comprises a nonbiodegradable inert porous polymeric matrix in which an active substance is dispersed, allowing for the prolonged release of the active substance within the second layer.Type: GrantFiled: June 21, 2000Date of Patent: April 16, 2002Assignee: Merck Patent GesellschaftInventors: Olivier Saslawski, Laurence Orlando
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Patent number: 6358525Abstract: A pharmaceutical composition has a blend of at least first and second components and a medicament in a sufficient amount to be therapeutic where the first component is hydroxypropylcellulose (HPC) and the second component is at least one other polymer selected from the group consisting of methylcellulose (MC), ethylhydroxyethylcellulose (EHEC), hydroxyethylmethylcellulose (HEMC), hydrophobically modified hydroxyethylcellulose (HMHEC), hydrophobically modified ethylhydroxyethylcellulose (HMEHEC), carboxymethylhydroxyethylcellulose (CMHEC), carboxymethyl hydrophobically modified hydroxyethylcellulose (CMHMHEC), guar, pectin, carrageenan, agar, algin, gellan gum, acacia, starch and modified starches, co-polymers of carboxyvinyl monomers, co-polymers of acrylate or methacrylate monomers, mono- and co-polymers of oxyethylene and oxypropylene and mixtures thereof and a medicament in a sufficient amount to be therapeutic, with the proviso that low-substituted hydroxypropylcellulose (L-HPC) is excluded from said firsType: GrantFiled: June 30, 1999Date of Patent: March 19, 2002Assignee: Hercules IncorporatedInventors: Jian Hwa Guo, George William Skinner
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Patent number: 6358537Abstract: A deodorant and antimicrobial dispersion is formed of a deodorant and antimicrobial component, a binder resin and an aqueous or oily liquid medium. The deodorant and antimicrobial component comprises an oxide or hydroxide of an alkaline earth metal, hydrated silica, and a cationic surfactant.Type: GrantFiled: May 3, 2000Date of Patent: March 19, 2002Assignee: Dainichiseika Color & Chemicals Mfg. Co, Ltd.Inventors: Akira Hoshino, Mikio Saji, Kozaburo Hayashi
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Patent number: 6352693Abstract: An effective poison bait composition is provided for the control of such objective pests as cockroaches, wherein the poison bait composition comprises (1) a pesticidally effective amount of a pesticidally active ingredient, (2) a carrageenan, and (3) glycerin. A methods of controlling objective pests is also provided, which utilizes the provided poison bait.Type: GrantFiled: April 7, 1999Date of Patent: March 5, 2002Assignee: Sumitomo Chemical Company, LimitedInventor: Hitoshi Kawada
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Patent number: 6350469Abstract: The present invention relates to a novel pharmaceutical composition and process for preparing swallowable methylcellulose tablets that disintegrate rapidly and meet USP standards in 0.1N hydrochloric acid as well as water.Type: GrantFiled: February 14, 2000Date of Patent: February 26, 2002Assignee: SmithKline Beecham CorporationInventors: Bruce Daggy, Naresh I Mehta, Priyashri Nayak
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Patent number: 6340473Abstract: Disclosed herein are compositions comprising a modified starch and a carrageenan, especially iota-carrageenan, where the compositions are suitable for use in manufacturing soft capsules.Type: GrantFiled: June 30, 2000Date of Patent: January 22, 2002Assignee: R.P. Scherer Technologies, Inc.Inventors: Keith Edward Tanner, Peter Robert Draper, John J. Getz, Stephen W. Burnett, Elizabeth Youngblood
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Patent number: 6335088Abstract: The present invention provides a moisture-retentive cooling gel, a laminate thereof, and a moisture-retentive cooling plaster, which offer moisture-retaining and cooling effects for a controlled duration and have superior functionality, e.g., capability of delivering and transporting an effective ingredient such as a pharmacological active ingredient, a perfume or a deodorant. The moisture-retentive cooling gel comprises: a water-retentive matrix (a1) of a water-soluble polymer having a water content of not lower than 40 wt %; and fibers (f) dispersed in the water-retentive matrix, the fibers (f) having a hydrophilic property at least at surfaces thereof, some of the fibers (f) being exposed on a surface of the water-retentive matrix (a1). The gel has a higher water content and a higher water vaporization rate. An endothermally water-dissolvable compound may be retained in the water-retentive matrix and/or the fibers for enhancement of the cooling capacity of the gel.Type: GrantFiled: April 29, 1999Date of Patent: January 1, 2002Assignee: Daiya Pharmaceutical Co., Ltd.Inventors: Shinji Morikane, Daizo Morikane
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Patent number: 6331540Abstract: Pharmaceutical compositions containing a fluoroquinolone antibiotic drug, xanthan gum and a water-soluble calcium salt in an amount sufficient to make the fluoroquinolone antibiotic drug and xanthan gum compatible are disclosed.Type: GrantFiled: October 10, 2000Date of Patent: December 18, 2001Assignee: Alcon Universal Ltd.Inventor: Bhagwati P. Kabra
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Patent number: 6326028Abstract: This invention relates to coatings employed to coat medicinal tablets. Such tablets include but are not limited to small pellet(s) of medication to be taken orally. In particular this invention relates to the use of alginates and/or gellan gum, mixtures thereof and the like as tablet coatings. More in particular, this invention relates to the use of alginate and gellan gum as tablet coatings for tablets which are useful for humans including coating(s) on medicinal tablets and to a process for making such coatings.Type: GrantFiled: October 30, 1998Date of Patent: December 4, 2001Assignee: Monsanto CompanyInventors: Thierry Nivaggioli, George Colegrove, John Flanagan
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Patent number: 6323241Abstract: The invention provides methods of treating erectile dysfunction comprising the step of placing within the fossa navicularis of the patient an effective erection-inducing amount of a prostaglandin E1 composition of a semi-solid consistency. The composition comprises prostaglandin E1, a penetration enhancer, a polysaccharide gum, a lipophilic compound, and an acidic buffer system. The penetration enhancer is an alkyl-2-(N,N-disubstituted amino)-alkanoate ester, an (N,N-disubstituted amino)-alkanol alkanoate, or a mixture of these. The lipophilic compound may be an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, or a mixture of these. The composition includes a buffer system capable of providing a buffered pH value for said composition in the range of about 3 to about 7.4.Type: GrantFiled: January 10, 2000Date of Patent: November 27, 2001Assignee: NexMed (Holdings) Inc.Inventors: James L. Yeager, Nadir Buyuktimkin, Servet Buyuktimkin
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Patent number: 6312730Abstract: A rapidly dispersible powder having use as a laxative and fiber supplement, comprising psyllium particles coated with gum arabic. The present invention also includes a method for making the powder that includes providing an effective quantity of gum arabic to a fluidized bed having the psyllium particles to make the rapidly dispersible powder. The present invention further includes a method for making a constipation treatment and a treatment for fiber supplementation.Type: GrantFiled: October 26, 1994Date of Patent: November 6, 2001Assignee: Johnson & Johnson. Merck Consumer Pharmaceuticals, Co.Inventor: Eugene H. Sander
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Publication number: 20010036482Abstract: Antimicrobial compositions containing an iodine compound and a carboxylic acid, for example, a fatty acid, are disclosed. The compositions can be formulated for use as a surgical scrub, wound antiseptic, pre-operative skin preparation, industrial sanitizer, antimicrobial soap, teat dip, etc. In one particularly advantageous embodiment, a composition of the invention is formulated as a teat dip further including a rheology modifier, at least one surfactant, suitable emollients, skin conditioners and lubricants.Type: ApplicationFiled: October 15, 1999Publication date: November 1, 2001Inventors: DALE LIND FREDELL, FRANCIS LAWRENCE RICHTER, BENJAMIN R. BODE
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Patent number: 6309666Abstract: A pharmaceutical preparation in the form of a coated capsule which can release contents of a capsule at a lower part of the digestive tract comprising (a) a hard capsule containing at least an acidic substance, (b) a polymer film soluble at low pH which is formed on a surface of said hard capsule, and (c) an enteric coating film which is formed on a surface of said polymer film soluble at low pH. According to the pharmaceutical preparation of the present invention, any kind of a medicament can be delivered to any desired site between the upper part of the small intestine and the lower part of the large intestine in the digestive tract by controlling the amount of polymer(s) used for the polymer film soluble at low pH and/or by selecting the kind of the polymer film soluble at low pH and/or the acidic substance without any complicated requirements for each medicament.Type: GrantFiled: July 15, 1996Date of Patent: October 30, 2001Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Harumi Hatano, Takahiro Ito, Takashi Ishibashi, Hiroyuki Yoshino, Masakazu Mizobe
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Patent number: 6284235Abstract: This invention relates to a method of producing a bioadhesive composition comprising the steps of preparing a solution of a solvent and a polymer mixture wherein the polymer mixture comprises at least one natural or synthetic polycarboxylated polymer and at least one polysaccharide; drying the solution to form a solid; and heat treating the solid to effect cross-linking and to form the bioadhesive composition.Type: GrantFiled: February 11, 2000Date of Patent: September 4, 2001Assignee: National Starch and Chemical Company Investment Holding CorporationInventors: Paul B. Foreman, Paul Richardson, John Tsai, Jean Paul Remon, Jody Voorspoels, Dieter Ameye, Catherine Callens
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Patent number: 6284270Abstract: The present invention relates to a means for creating a mass having structural integrity, including a rapidly disintegratable tablet for administration with or without the use of water. The present invention has a wide variety of different uses and applications. One embodiment is a tablet intended for oral administration. The tablet comprises at least one active ingredient and a mixture of excipients. The excipients provide desired characteristics and physical properties and when the tablet is sintered or heated, excellent tablet binding characteristics are obtained. The tablet is intended primarily for oral administration and dissolves in the presence of water. Also disclosed is a process for the preparation of a rapidly disintegratable tablet for administration with or without the use of water.Type: GrantFiled: August 4, 1999Date of Patent: September 4, 2001Assignee: Drugtech CorporationInventors: Yury Lagoviyer, R. Saul Levinson, Denis Stotler, Thomas C. Riley
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Patent number: 6277409Abstract: A coated tablet and process for making the same is provided. A molten composition comprising at least 50 weight percent of a thermoplastic material having a melting point of less than about 120° C. is applied to the tablet, and the molten composition is solidified into a protective coating. If desired, one or more outer coatings may be applied over the protective coating.Type: GrantFiled: February 11, 2000Date of Patent: August 21, 2001Assignee: McNeil-PPC, Inc.Inventors: Joseph R. Luber, Frank J. Bunick
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Patent number: 6274170Abstract: Compounds comprising multi-vitamins, zinc and an anti-platelet aggregating agent for the treatment of atherosclerotic cardiovascular disease (ASCVD) are disclosed. The compounds are provided in dosage form, and preferably include selected amounts of ascorbic acid, folic acid, vitamin E, vitamin B6 and vitamin B12. The anti-platelet aggregating agent preferably comprises aspirin. A protective coating is preferably provided between the aspirin and the other vitamin and mineral constituents. The dosages are effective in the treatment of ASCVD, and possess extended shelf lives.Type: GrantFiled: February 18, 1999Date of Patent: August 14, 2001Inventors: Richard Heibel, John J. Abbott
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Patent number: 6274168Abstract: A pharmaceutical composition is provided containing an admixture of phenytoin sodium and an erodible matrix which extends the release of the phenytoin sodium over about a two hour period. The erodible matrix comprises binder(s) and diluent(s) which control the release of drug from the pharmaceutical composition. The erodible matrix can further comprise an alkaline pH modifier.Type: GrantFiled: February 23, 1999Date of Patent: August 14, 2001Assignee: Mylan Pharmaceuticals Inc.Inventors: William J Addicks, Joseph P Duda, Daniel A. Snider, Kerry R Benson
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Patent number: 6267986Abstract: This invention relates to a process for the preparation of a controlled release pharmaceutical composition comprising two discrete zones wherein the first discrete zone comprises therapeutically effective amount of pseudoephedrine or its pharmaceutically acceptable salt as active ingredient and the second discrete zone comprises a therapeutically effective amount of a long-acting antihistamine selected from the group consisting of loratadine, azatidine, fexofenadine, terfenadine, cetirizine, astemizole, and levocabastine, or their pharmaceutically acceptable salt as active ingredient.Type: GrantFiled: September 24, 1999Date of Patent: July 31, 2001Assignee: Ranbaxy Laboratories LimitedInventors: Girish Kumar Jain, Ashok Rampal, Himadri Sen
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Patent number: 6264935Abstract: The present invention relates to ophthalmic compositions for the treatment of ocular hypertension and glaucoma, comprising a hypotonic solution of 0.1 to 0.2% (w/w) of xanthan gum and 0.5 to 5% (w/w) of a topical carbonic anhydrase inhibitor or an ophthalmologically acceptable salt thereof.Type: GrantFiled: June 14, 1999Date of Patent: July 24, 2001Assignee: Laboratoires MSD - ChibretInventors: Gilles Chastaing, Bernard Plazonnet, Annouk Rozier
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Patent number: 6261599Abstract: Bioavailable sustained release oral opioid analgesic dosage forms, comprising a plurality of multiparticulates produced via melt extrusion techniques disclosed.Type: GrantFiled: July 23, 1999Date of Patent: July 17, 2001Assignee: Euro-Celtique, S.A.Inventors: Benjamin Oshlack, Mark Chasin, Hua-Pin Huang, David Sackler
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Patent number: 6261577Abstract: Non-staining topical iodine disinfecting compositions having the ability to inactivate pathogens associated with skin infections or diseases. based upon the presence of molecular iodine in a concentration above at least 15 ppm. Any other iodine species selected from the group consisting of complexed iodine and triiodide may be present with the total of such other iodine species limited to a concentration of less than about 700 ppm so that any visible stain resulting from the application of this composition on the skin will dissipate without leaving any visible skin coloration.Type: GrantFiled: November 30, 1998Date of Patent: July 17, 2001Assignee: Symbollon CorporationInventor: Jack Kessler
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Patent number: 6245350Abstract: A process for encapsulation of caplets in a capsule comprises the following steps: a. providing empty capsule parts; b. filling at least one of said capsule parts with one or more caplets; c. putting said capsule parts together; and d. treating the combined parts by cold shrinking. The solid dosage forms obtainable by such a process are tamper-proof in that they cannot be opened in a way to be reassembled without showing such opening process.Type: GrantFiled: April 5, 1996Date of Patent: June 12, 2001Assignee: Warner-Lambert CompanyInventors: James Amey, Dominique Cade, Paul Maes, Robert Scott
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Patent number: 6224905Abstract: A method for preparing solid rapidly disintegrating dosage forms shaped as biconvex tablets having symmetrical top and bottom surfaces and dosage forms obtainable thereby.Type: GrantFiled: December 3, 1998Date of Patent: May 1, 2001Assignee: Janssen Pharmaceutica N.V.Inventors: Janice Lawrence, Gary Posage
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Patent number: 6221403Abstract: A topical composition for impregnating a bandage comprises zinc oxide in a stable oil in water emulsion. The emulsion comprises one or more fats or oils, one or more emulsifying agents, at least one water soluble gum and water. No preservative is required.Type: GrantFiled: February 8, 1995Date of Patent: April 24, 2001Assignee: Seton Healthcare Group PLCInventor: Michael Robert Nesbit
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Patent number: 6221393Abstract: The present invention relates to a delayed-release pharmaceutical composition which is in the form of tablets prepared by direct tableting and consisting of at least one active principle and a matrix which gives the said composition its delayed-release effect, characterized in that the said matrix consists at least in part of pregranulated polysaccharides of high molecular weight and of synthetic or natural origin.Type: GrantFiled: October 22, 1999Date of Patent: April 24, 2001Assignee: Rhodia ChimieInventors: Jean-Pierre Collaueri, Guillaume Conrath, Paul-Joël Derian, Gabriel Gousset, Frédéric Mauger
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Patent number: 6217903Abstract: A pharmaceutical composition has a blend of at least first and second components and a medicament in a sufficient amount to be therapeutic where the first component is ethylcellulose (EC) and the second component is at least one other polymer selected from the group consisting of methylcellulose (MC), ethylhydroxyethylcellulose (EHEC), hydroxyethylmethylcellulose (HEMC), hydrophobically modified hydroxyethylcellulose (HMHEC), hydrophobically modified ethylhydroxyethylcellulose (HMEHEC), carboxymethylhydroxyethylcellulose (CMHEC), carboxymethyl hydrophobically modified hydroxyethylcellulose (CMHMHEC), guar, pectin, carrageenan, agar, algin, gellan gum, acacia, starch and modified starches, mono- and co-polymers of carboxyvinyl monomers, mono- and co-polymers of acrylate or methacrylate monomers, mono- and co-polymers of oxyethylene and oxypropylene and mixtures thereof. The medicament can be a variety of drugs or nutritional supplements.Type: GrantFiled: June 30, 1999Date of Patent: April 17, 2001Assignee: Hercules IncorporatedInventor: George William Skinner
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Patent number: 6210710Abstract: A pharmaceutical composition has a blend of at least first and second components and a medicament in a sufficient amount to be therapeutic where the first component is selected from hydroxypropylcellulose (HPC), ethylcellulose (EC), or derivatives of HPC, EC, and hydroxyethylcellulose (HEC) and the second component is at least one other polymer. When HPC is the first component, hydroxypropylmethylcellulose (HPMC), HEC, or carboxymethylcellulose will not be the second component and when EC is the first component, HPMC will not be the second component. The medicament can be a variety of drugs or nutritional supplements. The pharmaceutical composition releases the medicament for a prolonged or sustained period of time and can be formulated into many dosage forms.Type: GrantFiled: April 28, 1997Date of Patent: April 3, 2001Assignee: Hercules IncorporatedInventor: George William Skinner
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Patent number: 6200554Abstract: Disclosed are conditioning shampoo compositions which provide improved hair or skin conditioning performance. These compositions comprise a detersive surfactant, select ethoxylated fatty alcohols having a fatty alcohol moiety containing from about 6 to about 30 carbon atoms and an ethoxylate chain containing from about 5 to about 150 moles of ethoxylation, a nonvolatile conditioning agent, preferably a nonvolatile silicone conditioning agent, having an average particle size of from about 5 um to about 2000 um, and water. The select ethoxylated fatty alcohols provide improved hair or skin conditioning by improving silicone deposition of large particle conditioning agents onto the hair or skin.Type: GrantFiled: October 16, 1996Date of Patent: March 13, 2001Assignee: The Procter & Gamble CompanyInventors: Thean Yeow Yeoh, Timothy Woodrow Coffindaffer, Hirotaka Uchiyama, John Gregory Schroeder, Yoshinari Okuyama
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Patent number: 6194000Abstract: Disclosed is a method for the therapeutic treatment of pain related to wind up in a human or animal. The method of the invention is practiced by administering to the subject an effective amount of an analgesic pharmaceutical composition which includes a NMDA receptor antagonist in an immediate release form combined with an NMDA receptor antagonist in a sustained release form. The immediate release form and sustained release forn are present in sufficient amounts to diminsh or abolish wind up.Type: GrantFiled: April 17, 1998Date of Patent: February 27, 2001Assignee: F.H. Faulding & Co., LimitedInventors: Ian Keith Smith, Grant Wayne Heinicke
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Patent number: 6180131Abstract: A process for feeding an animal a diet which alters the function and morphology of the gastrointestinal tract (GIT), a large lymphoid organ in the animal and which improves glucose metabolism, satiety, and nutrient absorption. The process involves feeding a companion animal such as, for example, a dog or cat a diet of a pet food composition containing fermentable fibers which have an organic matter disappearance (OMD) of 15 to 60 percent when fermented by fecal bacteria for a 24 hour period, the fibers being present in amounts from about 1 to 11 weight percent of supplemental total dietary fiber. The animal is maintained on the diet for a sufficient period of time to allow the fermentable fibers to ferment in the GIT of the animal.Type: GrantFiled: April 6, 1998Date of Patent: January 30, 2001Assignee: The Iams CompanyInventors: Gregory D. Sunvold, Michael G. Hayek
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Patent number: 6168805Abstract: A process for preparing solid, amorphous paroxetine comprising: (A) mixing paroxetine free base or a pharmaceutically acceptable paroxetine salt with water and pharmaceutically acceptable polymer; and (B) drying to form a composition comprising amorphous paroxetine and polymer, eliminating the need for organic solvents common for the solvent process. The resultant amorphous solid paroxetine composition is free from crystalline form, and yet has good handling properties, making it suitable for pharmaceutical use in the traditional tablet dosage form.Type: GrantFiled: May 7, 1998Date of Patent: January 2, 2001Assignee: Endo Pharmaceuticals, Inc.Inventors: William A. Hein, II, Sou-Chan Chang, Huai-Hung D. Kao
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Patent number: 6150422Abstract: A stable gelled composition, containing at least one lipophilic active agent sensitive to oxygen or to water or to both, and a solvent which contains, as gelling agent, at least one polysaccharide alkyl ether formed of units containing at least two different glycoside rings, each unit containing at least one hydroxyl group substituted with a saturated hydrocarbon alkyl group.Type: GrantFiled: March 11, 1997Date of Patent: November 21, 2000Assignee: L'OrealInventors: Didier Gagnebien, Pascal Simon
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Patent number: 6120803Abstract: The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix is surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.Type: GrantFiled: August 10, 1998Date of Patent: September 19, 2000Assignee: ALZA CorporationInventors: Patrick S. L. Wong, Liang-Chang Dong, David E. Edgren, Felix Theeuwes, Phyllis I. Gardner, Francisco Jao, Jason J. Wan
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Patent number: 6103269Abstract: The invention relates to accurately meterable shaped articles, for example granules or pellets, containing hydrophilic macromolecules, active compounds and optionally further pharmaceutically acceptable structure-forming substances and auxiliaries, the active compound being present in a matrix in dissolved, suspended or emulsified form, and a novel process for the production of these shaped articles, the process being particularly economically and ecologically acceptable, and use of the shaped articles as medicaments, in which the bioavailability, shelf life and tolerability is increased. Using the shaped articles or mixtures according to the invention, intermediates or final products for pharmacy, cosmetics, diagnosis, analysis or dietetics (healthcare) can additionally be advantageously prepared.Type: GrantFiled: March 1, 1999Date of Patent: August 15, 2000Assignee: Alfatec-Pharma GmbHInventors: Jens-Christian Wunderlich, Ursula Schick, Jurgen Werry, Jurgen Freidenreich
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Patent number: 6086904Abstract: Solid composition including a gum material and an tea tree oil and optionally another essential oil wherein the solid composition releases vapor containing the essential oil when exposed to an effective flow of gas. A method of diffusing tea tree oil into the atmosphere and a method of disinfecting air conditioning systems are also provided.Type: GrantFiled: April 29, 1999Date of Patent: July 11, 2000Assignees: Teeteeoh Research Group Pty Ltd, P. Guinane Pty LtdInventor: Ian Crawford
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Patent number: 6083531Abstract: The present invention relates to a solid pharmaceutical dosage form for oral administration, consisting essentially of(a) at least one active substance,(b) at least one filler,(c) at least one binding agent, and(d) optionally usual auxiliaries,which dosage form, however, does not contain agar;which dosage form is manufactured without applying any compression force to the mixture of the components (a), (b), (c) and (d); andwhich dosage form disintegrates when taken into the mouth within 15 seconds.Type: GrantFiled: October 7, 1998Date of Patent: July 4, 2000Assignee: Novartis Consumer Health S.A.Inventors: Pierre Humbert-Droz, Matthias Seidel, Rosa Martani
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Patent number: 6083532Abstract: Depot drug formulations include the pharmaceutical itself and a three component release rate controlling matrix composition. The three components of the matrix composition are (1) a pH dependent gelling polymer such as an alginate component, (2) an enteric polymer component, such as Eudragit.RTM. L or S, and (3) a pH independent gelling polymer, such as hydroxy propyl methyl cellulose or polyethylene oxide. The drug release rate can be adjusted by changing the amount of one or more of these components of the composition.Type: GrantFiled: December 5, 1997Date of Patent: July 4, 2000Assignee: Duramed Pharmaceuticals, Inc.Inventors: Guohua Zhang, Prasad Pinnamaraju, Muhammad Ali
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Patent number: 6083996Abstract: An aqueous pharmaceutical composition of a semi-solid consistency is provided for topical application of non-steroidal anti-inflammatory (NSAI) drugs. The composition comprises one or more NSAI drugs, a non-basic polymeric skin penetration enhancer and a lipophilic solvent. The polymeric skin penetration enhancer is present in an amount sufficient to enhance skin penetration of the NSAI drug. The lipophilic solvent is a mixture of an aliphatic C.sub.2 to C.sub.8 alcohol and an aliphatic C.sub.8 to C.sub.30 ester.Type: GrantFiled: November 5, 1997Date of Patent: July 4, 2000Assignee: NexMed Holdings, Inc.Inventors: Servet Buyuktimkin, Nadir Buyuktimkin, James Yeager
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Patent number: 6080426Abstract: A process for encapsulation of caplets in a capsule comprises the following steps: a. providing empty capsule parts; b. filling at least one of said capsule parts with one or more caplets; c. putting said capsule parts together; and d. treating the combined parts by cold shrinking. The solid dosage forms obtainable by such aprocess are tamper-proof in that they cannot be opened in a way to be reassembled without showing such opening process.Type: GrantFiled: January 11, 1996Date of Patent: June 27, 2000Assignee: Warner-Lamberg CompanyInventors: James Amey, Dominique Cade, Paul Maes, Robert Scott
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Patent number: 6063402Abstract: Disclosed is a substantially anhydrous, powdered, galactomannan composition consisting essentially of a galactomannan hydrocolloid exhibiting about 50% to about 90% by weight of anhydromannose residues and about 10% to about 50% by weight anhydrogalactose residues; less than about 1% by weight of protein material and less than about 3% of other nonaqueous impurities. This material is useful for preparing pharmaceutical compositions both in the substantially anhydrous form but preferably in an anhydrated form which includes about 5-15% by weight water. The pharmaceutical compositions comprise a therapeutically effective amount of a drug, the hydrated powered gallactomannan composition and optionally other pharmaceutically-acceptable excipients. When the hydrated powdered purified glactomannan of the invention is used to form a tablet, one sees improved hardness in the tablet formed.Type: GrantFiled: June 7, 1995Date of Patent: May 16, 2000Assignee: Venture Lending, A Division of Cupertino National BankInventors: Mark S. Gebert, David R. Friend, David Wong, Jagdish Parasrampuria
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Patent number: 6060078Abstract: The present invention relates to a chewable tablet containing a medicament in a core and a process for preparation thereof. In particular, the present invention relates to a chewable tablet comprising a core containing a medicament in the center of the tablet in a state of jelly or chewable base and an outer layer wrapping the core which is made up of chewable base such as a gum, a soft candy or a caramel. The chewable tablet is easy to take and has a good taste and nice chewing property due to the unique tablet form. In addition, the tablet has an advantage in bioavailability resulting from increased absorption rate and excellent stability due to unique preparation process. Therefore, the chewable tablet and the preparation process of the present invention can be used in pharmaceutical industry usefully.Type: GrantFiled: September 28, 1998Date of Patent: May 9, 2000Assignee: Sae Han Pharm Co., Ltd.Inventor: Young Won Lee
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Patent number: 6022565Abstract: A poison ivy (and related dermatitis) treatment composition and method in which a novel composition containing a combination of active ingredients gives new and unexpected results over compositions of the prior art. The inventive composition includes three essential ingredients: extract (fresh sap) of jewelweed (Impatiens species); fresh sap of plantain leaf; and an aqueous colloidal dispersion of subdivided whole oat grains. It is believed that the amphiphilic nature of the aqueous colloidal oat dispersion both preserves the activity of the plantain and jewelweed enzymes, as a result of its oat oil fraction, and also enhances topical delivery to the epidermis due to its aqueous fraction and the stabilizing effect of the oat bran as bulking agent.Type: GrantFiled: March 26, 1999Date of Patent: February 8, 2000Assignee: Albros, L.P.Inventors: Brian M. Albert, R. Richard Riso
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Patent number: 6010719Abstract: Freeze-dried disintegrating tablets, said tablets containing at least a therapeutic agent, a matrix forming agent and a binding agent, in which the tablets contain more than 20% by weight of a matrix forming agent selected from the group consisting of maltodextrins having a DE value between 12 and 40, isomalt and mixtures thereof, the weight ratio between said matrix forming agent and the binding agent being comprised between 2:1 and 50:1.Type: GrantFiled: September 16, 1997Date of Patent: January 4, 2000Assignee: Universiteit GentInventors: Jean Paul Remon, Sam Corveleyn
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Patent number: 5997907Abstract: Methods for enhancing the stability of thickening agent solutions, especially guar solutions, by sterilizing the solution with UV light and/or adding a surfactant to the solution are disclosed. Thickening agent solutions and powders, including guar solutions and powders, as well as products made from these solutions and powders, are also disclosed.Type: GrantFiled: December 19, 1997Date of Patent: December 7, 1999Assignee: Rhodia Inc.Inventors: Animesh Goswami, Paul-Joel Derian
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Patent number: 5968551Abstract: Sustained release oral solid dosage forms of opioid analgesics are provided as multiparticulate systems which are bioavailable and which provide effective blood levels of the opioid analgesic for at least about 24 hours. A unit dose of the opioid analgesic contains a plurality of substrates including the opioid analgesic in sustained release form. The substrates have a diameter from about 0.1 mm to about 3 mm.Type: GrantFiled: July 27, 1995Date of Patent: October 19, 1999Assignee: Purdue Pharma L.P.Inventors: Benjamin Oshlack, Mark Chasin
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Patent number: 5955104Abstract: A multiple unit oral pharmaceutical dosage form having a plurality of pellets in a water soluble capsule or in a tablet compressed from the pellets, wherein each pellet contains (a) a substantially inert core, (b) an active ingredient layer over the inert core, and containing (i) a pharmacologically active particulate active ingredient, (ii) a nonembedding amount of a binder for adhering the active ingredient over the inert core, and optionally (iii) a pharmaceutically acceptable, inert adjuvant, such as colloidal silica, and (c) a coating over the active ingredient layer for retarding the release of the active ingredient from the active ingredient layer into an aqueous body fluid solvent in situ, the nonembedding amount of the binder is suitably from about 1% wt. to about 10% wt.Type: GrantFiled: July 18, 1997Date of Patent: September 21, 1999Assignee: Asta Medica AGInventors: Helmut Momberger, Marc Raber, Dieter Kuhn, Wolfgang Schmid
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Patent number: 5942233Abstract: This invention relates to an herb composition which comprises an amount of 30 to 45% by weight of one or more herbs for invigorating of blood circulation, an amount of 55 to 70% by weight of one or more herbs for excreting toxin from human body, and an amount of 0.Type: GrantFiled: March 14, 1997Date of Patent: August 24, 1999Inventor: Teh Shan Chang
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Patent number: RE37020Abstract: The present invention provides a method for providing nutrition to elderly patients. Pursuant to the present invention, the enteral composition includes a protein source, a lipid source, and a carbohydrate source. Preferably, the protein source includes at least 18% of the total calories. In an embodiment, the carbohydrate source includes a source of dietary fiber including a balance of soluble to insoluble fiber ratio of approximately 1:3. Still further, the composition of the present invention also includes increased levels of certain vitamins and minerals.Type: GrantFiled: July 9, 1998Date of Patent: January 16, 2001Assignee: Nestec, Ltd.Inventors: Paul M. Lin, Shen-Youn Chang, Chris Kruzel
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Patent number: RE36288Abstract: The present invention provides a method for providing nutrition to elderly patients. Pursuant to the present invention, the enteral composition includes a protein source, a lipid source, and a carbohydrate source. Preferably, the protein source includes at least 18% of the total calories. In an embodiment, the carbohydrate source includes a source of dietary fiber including a balance of soluble to insoluble fiber ratio of approximately 1:3. Still further, the composition of the present invention also includes increased levels of certain vitamins and minerals.Type: GrantFiled: July 9, 1998Date of Patent: August 31, 1999Assignee: Nestec Ltd.Inventors: Paul M. Lin, Shen-Youn Chang, Chris Kruzel