Natural Gum Or Resin Patents (Class 514/782)
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Patent number: 5928655Abstract: A compact solid gel is described containing water, that consists of water in a concentration ranging from 15% to 90%, thermoreversible polysaccharides in a concentration ranging from 0.3% to 4%, humectant compounds in a concentration ranging from 4% to 40%, and powder phase in a concentration ranging from 2% to 35%.Type: GrantFiled: April 22, 1997Date of Patent: July 27, 1999Assignee: Intercos Italia S.p.A.Inventor: Nadia Avalle
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Patent number: 5902606Abstract: Sparingly water-soluble active compounds, for example medicinal substances, are converted into the dissolved (molecularly disperse) state by dissolving them in a hydrophilic peptide having a molecular weight above 100 D, for example gelatin. The solubility both during storage and during use of the formulation by the user or patient is thereby ensured, without organic solvents or solubilizing agents which cause undesirable side effects being required.Type: GrantFiled: March 17, 1995Date of Patent: May 11, 1999Assignee: Alfatec-Pharma GmbHInventors: Jens-Christian Wunderlich, Ursula Schick, Jurgen Werry, Jurgen Freidenreich
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Patent number: 5888515Abstract: A poison ivy (and related dermatitis) treatment composition and method in which a novel composition containing a combination of active ingredients gives new and unexpected results over compositions of the prior art. The inventive composition includes three essential ingredients: extract (fresh sap) of jewelweed (Impatiens species); fresh sap of plantain leaf; and an aqueous colloidal dispersion of subdivided whole oat grains. It is believed that the amphiphilic nature of the aqueous colloidal oat dispersion both preserves the activity of the plantain and jewelweed enzymes, as a result of its oat oil fraction, and also enhances topical delivery to the epidermis due to its aqueous fraction and the stabilizing effect of the oat bran as bulking agent.Type: GrantFiled: December 11, 1997Date of Patent: March 30, 1999Assignee: Albros, L.P.Inventors: Brian M. Albert, R. Richard Riso
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Patent number: 5888534Abstract: A composition providing a relatively slow release of water-soluble drugs, such as apomorphine, for delivery via the sublingual or buccal routes.Type: GrantFiled: April 29, 1997Date of Patent: March 30, 1999Assignee: Pentech Pharmaceuticals, Inc.Inventors: Ragab El-Rashidy, Bruce Ronsen, Emad Eldin Hassan
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Patent number: 5886054Abstract: The present invention relates to a therapeutic composition comprising an aqueous solution of at least one polymer and at least one electrolyte, wherein the aqueous solution is preferably buffered and optionally contains at least one mucin. The polymer can be chosen for instance from the group which consists of scleroglucan, guar gum, xanthane gum, sodium carboxymethyl cellulose, hydroxyethyl cellulose, polyacrylic acid and polyvinyl alcohol. The therapeutic composition according to the invention can serve as saliva substitution agent, artificial tear water, in a mouth rinse or in a toothpaste.Type: GrantFiled: September 23, 1996Date of Patent: March 23, 1999Assignee: Stichting Voor De Technische WetenschappenInventors: Arie Van Nieuw Amerongen, Engelmundus Cornelis Ignatius Veerman, Willy Alexander Van Der Reijden
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Patent number: 5885617Abstract: A dry moisture barrier film coating composition for forming a moisture barrier film coating for pharmaceutical tablets and the like comprises polyvinyl alcohol, soya lecithin, and optionally a flow aid, a colorant, and/or a suspending agent. A liquid coating solution or dispersion for forming a moisture barrier film coating for pharmaceutical tablets and the like comprises polyvinyl alcohol, soya lecithin, water, and optionally a flow aid, a colorant, and/or a suspending agent. A method of coating pharmaceutical tablets and the like with a moisture barrier film coating comprises forming a liquid coating solution or dispersion for forming a moisture barrier film coating for pharmaceutical tablets and the like comprising polyvinyl alcohol, soya lecithin, water, and optionally a flow aid, a colorant, and/or a suspending agent, applying the coating solution or dispersion onto the tablets to form a film coating on the tablets, and drying the film coating on the tablets.Type: GrantFiled: June 6, 1995Date of Patent: March 23, 1999Assignee: BPSI Holdings, Inc.Inventor: Martin Philip Jordan
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Patent number: 5882689Abstract: This invention provides a method for controlling soilborne fungal disease in cultivated field plants such as a peanut crop. Field crop soil is treated with a free-flowing granular fungicide composition which can be applied by aerial means with minimal settling on plant foliage. The granular fungicide composition comprises ammonium bicarbonate and a solid surfactant ingredient, and is effective against soilborne fungi such as a Sclerotinia, Rhizoctonia, Pythium, Fusarium, Phytophthora or Verticillium species.Type: GrantFiled: December 23, 1997Date of Patent: March 16, 1999Assignee: Church & Dwight Co., Inc.Inventors: M. Steven Lajoie, Carl E. Henry
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Patent number: 5876754Abstract: The invention relates to accurately meterable shaped articles, for example granules or pellets, containing hydrophilic macromolecules, active compounds and optionally further pharmaceutically acceptable structure-forming substances and auxiliaries, the active compound being present in a matrix in dissolved, suspended or emulsified form, and a novel process for the production of these shaped articles, the process being particularly economically and ecologically acceptable, and use of the shaped articles as medicaments, in which the bioavailability, shelf life and tolerability is increased. Using the shaped articles or mixtures according to the invention, intermediates or final products for pharmacy, cosmetics, diagnosis, analysis or dietetics (healthcare) can additionally be advantageously prepared.Type: GrantFiled: December 19, 1994Date of Patent: March 2, 1999Assignee: Alfatec-Pharma GmbHInventors: Jens-Christian Wunderlich, Ursula Schick, Jurgen Werry, Jurgen Freidenreich
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Patent number: 5874096Abstract: Aerial spray or discharge drift is controlled in aqueous compositions via the use of selected non-visco-elastic amounts of guar, one or more derivatives of guar, or combinations thereof.Type: GrantFiled: August 26, 1996Date of Patent: February 23, 1999Assignee: Rhodia Inc.Inventor: James Lyle Hazen
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Patent number: 5874103Abstract: An aqueous base suspension concentrate of an ionophore antibiotic or ionophore antibiotics capable of aqueous dilution (if desired) and capable (with or without such aqueous dilution) of being orally administered to an animal (eg; by drenching), said concentration comprising(I) at least one ionophore antibiotic in (II) an aqueous system containing( ) a wetting and/or surfactant agent(ii) an antifreeze agent or agents in which the ionophore antibiotic or antibiotics is or are no more than sparingly soluble,(iii) a suspension agent,(iv) optionally an antifoam agent or system,(v) optionally a preservative,(vi) optionally a de-bittering agent,(vii) optionally a pH buffering system, and(viii) water.Type: GrantFiled: July 23, 1996Date of Patent: February 23, 1999Assignee: Eli Lilly and CompanyInventors: Derek George Moore, Lionel Barry Lowe, Kevin Charles Palmer, Kim Ewing Melville Agnew
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Patent number: 5874402Abstract: Methods are provided for the treatment of a host suffering from a cellular proliferative disease through administration of a chemotherapeutic agent in conjunction with a cell membrane permeant. Optionally, the cell membrane permeant and/or chemotherapeutic agent will be present in a pharmaceutically acceptable vehicle capable of acting as a depot. In the subject methods, the chemotherapeutic agent and membrane permeant are administered at least proximal to a target site of the host. Administration of chemotherapeutic agents in accordance with the subject methods results in improved efficacy of, and/or decreased host toxicity to, the intralesionally administered chemotherapeutic agent.Type: GrantFiled: May 16, 1997Date of Patent: February 23, 1999Assignee: Matrix Pharmaceutical, Inc.Inventors: Saira Singh, Richard E. Jones, Dennis M. Brown
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Patent number: 5869029Abstract: This invention provides compositions comprising particulate water-soluble or water-swellable polymer at least partially agglomerated by treatment with at least one polyol, wherein the polyol is present at a level greater than about 10 wt. % based on the total weight of the composition. The particulate water-soluble or water-swellable polymer which has been at least partially agglomerated by treatment with polyol hydrates in water-containing solvents substantially faster than untreated water-soluble or water-swellable polymer, without formation of polymer lumps. The invention further provides an improved process for preparing a toothpaste composition comprising at least one dry, water-soluble or water-swellable polymer, the improvement comprising substituting for the dry, water-soluble or water-swellable polymer, particulate water-soluble or water-swellable polymer which has been at least partially agglomerated by treatment with polyol.Type: GrantFiled: June 21, 1996Date of Patent: February 9, 1999Assignee: Hercules IncorporatedInventors: Arne Graff-Andersen, Jashawant J. Modi
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Patent number: 5858380Abstract: A stable gelled composition is provided which can contain a large amount of electrolyte and which contains, as gelling agent, a polysaccharide alkyl ether formed from units containing at least two different monosaccharides, each unit containing at least one saturated alkyl ether group. The polysaccharide alkyl ether preferably has a molecular weight of greater than 200,000 and is in particular a guar gum alkyl ether having a degree of substitution of approximately 2 to 3, preferably about 2.5. The composition obtained can be used in the cosmetics and/or dermatological fields for the treatment and care of the skin, scalp, mucous membranes, nails and hair.Type: GrantFiled: March 12, 1997Date of Patent: January 12, 1999Assignee: L'OrealInventor: Didier Gagnebien
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Patent number: 5849266Abstract: The invention relates to an oral composition for the treatment and prevention of dental hypersensitivity comprising an anti-hypersensitivity agent embedded in a sustained release carrier such as a cellulosic or hydrophobic polymer, and a method for the use of said composition in treating and preventing dental hypersensitivity. The invention also provides for the supplementation of said oral composition with an adhesive and a plasticizer to increase the effectiveness of the anti-hypersensitivity agent.Type: GrantFiled: April 4, 1995Date of Patent: December 15, 1998Assignee: Perio Products Ltd.Inventor: Michael Friedman
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Patent number: 5840329Abstract: A pulsatile drug delivery system comprising of a plurality of particles is able to deliver drug in any desired patterns. A plurality of particles with multi-layer core capable of short-pulse release interlaced with long-duration release is designed for delivery of multi-agents simultaneously or sequentially, or single agent, according to a pre-programmed profile.Type: GrantFiled: May 15, 1997Date of Patent: November 24, 1998Assignee: BioAdvances LLCInventor: Jane Pei-Fan Bai
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Patent number: 5811112Abstract: Cosmetic oil-in-water emulsions which are intended to be left on the skin after application (not rinsed off) the emulsions incorporating a stabilized protease. The cosmetic emulsions useful in treatment of dry, flaky, rough, aged, wrinkled or cellulotic skin.Type: GrantFiled: May 30, 1997Date of Patent: September 22, 1998Assignee: Chesebrough-Pond's USA Co., Division of Conopco Inc.Inventors: Prem Chandar, Norman Kramer Richardson, Alyse Battaglia, Karla Jean Cicciari, Kara Newell El-Kadi
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Patent number: 5811388Abstract: Pharmaceutical compositions for orally delivering a therapeutically effective amount of a drug to the colon without significant release of the drug in the upper GI tract after oral administration of the composition are described. The composition is a unit dosage in the form of a tablet that comprises about 0.01% by weight to about 10% by weight of the drug that is useful in treating a colonic disorder or that is absorbed from the colon; about 40% by weight to about 98% by weight of a hydrocolloid gum obtainable from higher plants; and about 2% by weight to about 50% by weight of a pharmaceutically acceptable binder. The compositions are useful for treating lower GI disorders in human subjects by administering a suitable amount to a subject in need thereof. A particularly preferred aspect is the process for preparing such composition in the form of a tablet.Type: GrantFiled: February 16, 1996Date of Patent: September 22, 1998Assignee: Cibus Pharmaceutical, Inc.Inventors: David R. Friend, David Wong
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Patent number: 5780060Abstract: Microcapsules based on crosslinked plant polyphenols are described. These microcapsules are obtained by the interfacial crosslinking of plant polyphenols, particularly flavonoids. When incorporated in a composition such as a cosmetic, pharmaceutical, dietetic or food composition, these microcapsules make it possible to prevent any impairment of this composition, in particular any color modification, while at the same time preserving the activity, especially the anti-free radical and/or antioxidizing activity, of the plant polyphenols, particularly the flavonoids.Type: GrantFiled: September 27, 1995Date of Patent: July 14, 1998Assignee: Centre National de la Recherche ScientifiqueInventors: Marie-Christine Levy, Marie-Christine Andry
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Patent number: 5773025Abstract: Sustained release oral solid dosage forms comprising agglomerated particles of a therapeutically active medicament in amorphous form, a gelling agent, an ionizable gel strength enhancing agent and an inert diluent, as well as processes for preparing and using the same are disclosed. The sustained release oral solid dosage forms are useful in the treatment of hypertension in human patients.Type: GrantFiled: April 18, 1996Date of Patent: June 30, 1998Assignee: Edward Mendell Co., Inc.Inventor: Anand Baichwal
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Patent number: 5762962Abstract: Antacid pharmaceutical compositions provide optimal buffering profiles of from 3.0 to 5.0 for immediate and long lasting relief from the symptoms of acid indigestion, sour stomach, heartburn and gas. The composition may comprise a dual or tripartite combination of the actives calcium carbonate, calcium or magnesium citrate and/or calcium phosphate which, as a result of their different activities, neutralize the excess stomach acid both immediately and continuously over time. The formulations also provide the individual with alternative dosage forms which may provide greater levels of calcium, less sodium and less production of gastrointestinal gas.Type: GrantFiled: October 5, 1994Date of Patent: June 9, 1998Assignee: Warner-Lambert CompanyInventors: Constantine Georgiades, R. Michael Buch, E. Eric Engelman, Frank A. Volpe
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Patent number: 5736161Abstract: The preparation consists of millispheres, microspheres, nanospheres or array-type particles consisting of a nucleus of a gellable hydrocolloid onto which has been deposited a film of a cationic polysaccharide, and incorporating inside a pharmacologically useful drug. The procedure consists of dissolving, suspending or emulsifying the drug in a solution of the gellable hydrocolloid; adding the resulting mixture to a gelling solution; and suspending the resulting millispheres, microspheres, nanospheres or array-type particles in a solution of the cationic polysaccharide.Type: GrantFiled: July 21, 1994Date of Patent: April 7, 1998Assignee: Lipotec S.A.Inventors: Jose de los Santos Garces, Angel Bonilla Munoz, Jose Maria Garcia Anton
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Patent number: 5728740Abstract: A method of treating bacterial infection is disclosed. The method comprises the step of applying to a plant having a bacterial infection a composition comprising a xylene source and a wood rosin source, wherein xylene and wood rosin from the xylene source and wood rosin source are present in amounts effective to treat bacterial infection in the plant.Type: GrantFiled: December 5, 1996Date of Patent: March 17, 1998Inventor: Mark William Barrett
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Patent number: 5719197Abstract: Compositions for topical application comprising a therapeutically effective amount of a pharmaceutical agent(s), a pharmaceutically acceptable bioadhesive carrier, a solvent for the pharmaceutical agent(s) in the carrier and a clay, and methods of administering the pharmaceutical agents to a mammal are disclosed.Type: GrantFiled: June 7, 1995Date of Patent: February 17, 1998Assignee: Noven Pharmaceuticals, Inc.Inventors: David P. Kanios, Joseph A. Gentile, Juan A. Mantelle, Steven Sablotsky
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Patent number: 5700478Abstract: Water-soluble pressure-sensitive adhesives include a water-soluble polymer that is made tacky at room temperature by addition of a water-soluble plasticizer that is miscible with the polymer. Suitable polymers are solid at room temperature; and have a hydrophilicity as measured by water uptake greater than about 25%; they are liquid at room temperature and have a boiling point higher than about 80.degree. C. The adhesives according to the invention may conveniently be provided in dry film form. Preferred water-soluble pressure-sensitive adhesives of the invention adhere both to mucosal surfaces and to a variety of materials that may constitute a part of a device or prosthesis to be held in a body cavity that has a mucosal lining. Also, a laminated device for the controlled release of a substance within a mucosa-lined body cavity includes the substance dissolved or dispersed in either or both of a water-soluble pressure-sensitive adhesive layer and optionally one or more water-soluble polymer layers.Type: GrantFiled: August 3, 1995Date of Patent: December 23, 1997Assignee: Cygnus, Inc.Inventors: James E. Biegajski, Subbu S. Venkatraman, Ann M. Scott
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Patent number: 5688529Abstract: High dose, dry granulations or powder blends and aqueous oral suspensions of mycophenolate mofetil or mycophenolic acid, contain: active compound (7.5-30%), suspending/viscosity agent, sweetener, flavor, buffer (to a pH of 5-7.5), and optionally contain flavor enhancer, wetting agent, antimicrobial agent and color.Type: GrantFiled: March 29, 1995Date of Patent: November 18, 1997Assignee: Syntex (U.S.A) Inc.Inventors: Deborah Marilyn Lidgate, Li-hua Wang-Kessler, Bindu Joshi, Sayee Gojanan Hegde, Leo Gu
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Patent number: 5688521Abstract: Object of the invention is a single dose form of application for lactulose in the form of pastilles based on at least partially or completely water soluble natural and/or synthetic polymers selected from gums, alginates, carrageen, starch, pectin, and gelatin comprising lactulose as active substance, as well as a process to prepare the said pastilles.Type: GrantFiled: December 1, 1995Date of Patent: November 18, 1997Assignee: Bolder Arzneimittel GmbHInventors: Hermann-Josef Bolder, Faruk Imer
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Patent number: 5686385Abstract: The present invention provides microcapsule comprising agricultural active ingredients with improved physical properties, and an agricultural composition comprising said microcapsule. An agricultural microcapsule having a diameter of not more than 50 .mu.m comprises an agricultural active ingredient in a water-soluble coating material. As an agricultural composition comprising said microcapsules, DL dust, solidified emulsifiable concentrate can be provided.According to the present invention, the agricultural active ingredient is stabilized, agricultural dust can be mixed with even incompatible, liquid agricultural active ingredient, and agricultural microcapsule has excellent handling properties.Type: GrantFiled: June 5, 1995Date of Patent: November 11, 1997Assignee: Takeda Chemical Industries, Ltd.Inventors: Kanji Akashi, Chikara Tanabayashi, Kazutaka Kitagawa
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Patent number: 5686429Abstract: The present invention provides a method for providing nutrition to elderly patients. Pursuant to the present invention, the enteral composition includes a protein source, a lipid source, and a carbohydrate source. Preferably, the protein source includes at least 18% of the total calories. In an embodiment, the carbohydrate source includes a source of dietary fiber including a balance of soluble to insoluble fiber ratio of approximately 1:3. Still further, the composition of the present invention also includes increased levels of certain vitamins and minerals.Type: GrantFiled: December 17, 1996Date of Patent: November 11, 1997Assignee: Nestec LtdInventors: Paul M. Lin, Shen-Youn Chang, Chris Kruzel
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Patent number: 5684051Abstract: Elastically deformable medical devices, such as stents, having improved speed and degree of shape recovery are made by treating shaped hydrogels containing a polymer with a solution containing at least one elasticity agent, which may be nonionic or ionic. For example, polysaccharide-based hydrogels, such as barium alginate, are formed into tubing, shaped into pigtail stents, and exposed to an aqueous solution containing an elasticity agent such as potassium ions, sodium ions, sorbitol, glucose, citric acid, mannitol, dulcitol, or glycerol. The solution may also contain a crosslinking agent, such as calcium ions, to achieve the desired degree of elasticity.Type: GrantFiled: April 24, 1996Date of Patent: November 4, 1997Assignee: Hercules IncorporatedInventor: Samuel Anthony Thompson
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Patent number: 5662935Abstract: An improved process for preparing controlled release pharmaceutical forms comprises exposing a mixture comprising one or more excipients and one or more active ingredients compatible with each other and with said excipients to mechanical or electromechanical actions for a well established time and within a wide range of frequencies to give tablets, matrices or mono or multilayered films. Said forms can be optionally crushed to give a granulate or powder. Depending on the employed excipient, a delayed or rapid but always controllable release of the active ingredient can be attained.Type: GrantFiled: June 23, 1995Date of Patent: September 2, 1997Assignee: Saitec S.R.L.Inventor: Giuseppe Motta
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Patent number: 5656294Abstract: Pharmaceutical compositions for orally delivering a therapeutically effective amount of a drug to the colon without significant release of the drug in the upper GI tract after oral administration of the composition are described. The composition comprises about 0.5% by weight to about 10% by weight of the drug that is useful in treating a colonic disorder or that is absorbed from the colon; about 40% by weight to about 80% by weight of a hydrocolloid gum obtainable from higher plants; and about 10% by weight to about 50% by weight of a pharmaceutically acceptable binder. The compositions are useful for treating colon disorders in human subjects by administering a suitable amount to a subject in need thereof. A particularly preferred aspect is the process for preparing such composition in the form of a tablet.Type: GrantFiled: June 7, 1995Date of Patent: August 12, 1997Assignee: Cibus Pharmaceutical, Inc.Inventors: David R. Friend, David Wong
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Patent number: 5641511Abstract: A novel granular drug delivery system having a gel-forming dietary fiber that can be made into a an orally-ingestible dispersion by admixture with a liquid that can deliver an effective dose of a pharmaceutically-active compound. The granular drug delivery system comprises granules consisting essentially of a pharmaceutically active compound, and a gel-forming dietary fiber, the granules being coated with at least one of the following: a gel-forming dietary fiber, a starch or a protein. The composition may further include a mineral salt that releases a physiologically-acceptable gas upon ingestion. The composition of the granular drug delivery system will deliver microgram quantities of a pharmaceutically-active compound in an orally-ingestible dispersion without forming a thick gel and without forming "hot" and "cold" spots of the pharmaceutically-active compound.Type: GrantFiled: September 13, 1995Date of Patent: June 24, 1997Assignee: Cibus PharmaceuticalInventor: Eric H. Kuhrts
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Patent number: 5639796Abstract: The present invention is an injectable medical composition useful for replacing natural lubricating fluids in the body of humans or animals. The method and composition can be used for the treatment of joints and other parts of the body wherein natural lubrication between surfaces is deficient or where additional lubrication is required. The composition comprises a hydrophilic polymer suspended in a hydrophobic carrier so that the suspension is easily injectable into the desired body part. After injection, the carrier diffuses away from the polymer and is replaced by aqueous body fluids thereby causing the polymer to absorb or adsorb water forming a viscous, lubricating fluid.Type: GrantFiled: September 7, 1993Date of Patent: June 17, 1997Assignee: C.R. Bard, Inc.Inventor: Clarence C. Lee
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Patent number: 5635492Abstract: A teat-treating composition comprising a biocide in an aqueous medium characterised in that it also comprises a pseudo-plastically- or thixotropically-effective amount of Rhamsan gum is disclosed, as is the production thereof by mixing the components.Such compositions may be used to counter mastitis, particularly in dairy cattle, by dipping or spraying cows' teats.Type: GrantFiled: September 3, 1991Date of Patent: June 3, 1997Assignee: Diversey Lever, Inc.Inventor: Michael P. Corby
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Patent number: 5631026Abstract: The present invention relates to an aqueous pharmaceutical suspension for oral use, and a method of preparation, having antacid and antiulcer properties which contains a therapeutically effective amount of calcium carbonate in combination with magnesium carbonate and/or magnesium trisilicate and a carboxylic acid pH adjusting agent.Type: GrantFiled: May 31, 1995Date of Patent: May 20, 1997Assignee: McNeil-PPC, Inc.Inventors: Douglas S. Beyerle, Gerard P. McNally
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Patent number: 5629350Abstract: Stable, concentrated aqueous suspensions of ortho-phenylphenol (OPP) which contribute minimal chemical oxygen demand and methods of preparing and using said suspensions in biocidal applications have been discovered. The formulations comprise from about 3 to about 70 weight percent of OPP suspended in about 30 to about 97 weight percent water in the presence of a suspending amount of a thixotrope that exhibits Ellis-Plastic behavior.Type: GrantFiled: March 20, 1996Date of Patent: May 13, 1997Assignee: The Dow Chemical CompanyInventor: Charles D. Gartner
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Patent number: 5624683Abstract: A sustained-release multi-granule tablet is obtained by compressing sustained-release granules, which contains a basis, and a formulation adjuvant. Each of the granules has been coated in advance with a layer of the formulation adjuvant and/or a layer of a mixture of the formulation adjuvant and the basis. The tablet releases an active substance at a suitable velocity into the digestion tract, resulting in that the inbalance in the absorption of the drug in each patient and among individual patients is minimized to achieve maximum bioavailability.Type: GrantFiled: February 7, 1994Date of Patent: April 29, 1997Assignee: Eisai Co., Ltd.Inventors: Hidenobu Andoh, Sumio Watanabe, Yasuo Miyake
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Patent number: 5614217Abstract: A gelatin capsule that is generally resistant to humidity having a non-hygroscopic plasticizer and an elasticity reducing gelatin extender in the formulation of the gelatin capsule shell. The capsule is capable of being manufactured on conventional rotary die encapsulation devices and can readily hold liquid fill materials. The capsule is breakable with manual pressure.Type: GrantFiled: June 7, 1995Date of Patent: March 25, 1997Assignee: R.P. Scherer CorporationInventors: Timothy B. Chiprich, Michael T. Hoylman, Norman S. Stroud
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Patent number: 5599557Abstract: A dry hydrated cephalosporin, e.g. ceftibuten having about 7 to 14% by weight of water, powder formulation, pharmaceutical compositions in the form of an oral suspension dosage form and a method of making the dry powder formulations are disclosed.Type: GrantFiled: October 27, 1994Date of Patent: February 4, 1997Assignee: Schering CorporationInventors: Donald A. Johnson, Lorraine Wearley, Rebecca Galeos, Joel A. Sequeira
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Patent number: 5599528Abstract: A preparation for epidermis containing kojic acid and/or its derivative and a surfactant or surfactants having HLB value adjusted to 12 or less than that is disclosed. This preparation is preferably in a form of O/W emulsion or W/O emulsion, with the latter being preferably formed by gel emulsification process. The surfactants or surface active agents serve to depress coloration or decomposition of kojic acid and/or its derivative and improve application feel of the preparation.Type: GrantFiled: May 5, 1994Date of Patent: February 4, 1997Assignee: Sansho Seiyaku Co., Ltd.Inventor: Takahisa Igaki
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Patent number: 5589468Abstract: The present invention provides a method for providing nutrition to elderly patients. Pursuant to the present invention, the enteral composition includes a protein source, a lipid source, and a carbohydrate source. Preferably, the protein source includes at least 18% of the total calories. In an embodiment, the carbohydrate source includes a source of dietary fiber including a balance of soluble to insoluble fiber ratio of approximately 1:3. Still further, the composition of the present invention also includes increased levels of certain vitamins and minerals.Type: GrantFiled: January 13, 1995Date of Patent: December 31, 1996Assignee: Clintec Nutrition Co.Inventors: Paul M. Lin, Shen-Youn Chang, Chris Kruzel
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Patent number: 5576021Abstract: A sustained-release multi-granule tablet is obtained by compressing sustained-release granules, which contains an active substance, and a formulation adjuvant. Each of the granules has been coated in advance with a layer of the formulation adjuvant and/or a layer of a mixture of the formulation adjuvant and the active substance. The tablet releases an active substance at a suitable velocity into the digestion tract, resulting in that the variability in the absorption of the drug in each patient and among individual patients is minimized to achieve maximum bioavailability.Type: GrantFiled: July 15, 1994Date of Patent: November 19, 1996Assignee: Eisai Co., Ltd.Inventors: Hidenobu Andoh, Sumio Watanabe, Yasuo Miyake
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Patent number: 5549914Abstract: Thermally stable collagen gels formed by the addition of small amounts of neutralized slightly cross-linked polyacrylic acid. Thermally stable gels resulting from 0.3 to 4.0 percent by weight of collagen and 0.10 to 0.50 percent by weight of neutralized slightly cross-linked polyacrylic acid. The thermally stable gels are useful in wound care management. Further, synergistic effects are noted by the addition of 0.5 to 3.0 percent by weight of natural gums, particularly those containing glucuronic acid segments. Gelatin, a partially hydrolyzed collagen, behaves in a similar manner to collagen.Type: GrantFiled: September 30, 1994Date of Patent: August 27, 1996Assignee: Sween CorporationInventor: Elliott Farber
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Patent number: 5527540Abstract: In the pharmaceutical formulation of at least one alkali-sensitive active substance with an effervescent system, the carbonate component is embedded in at least one edible, organic acid and is preferably covered by said acid or by another acid. The active substance is embedded in at least one of the following compounds: an edible, organic acid, a higher alcohol, a hydrocolloid or a relatively long-chain polyvinylpyrrolidone, preferably covered with at least one of the stated compounds. The contact zone between active substance and effervescent system should have a pH of not more than 4.5. Both effervescent system particles and active substance particles, which are embedded or optionally covered in this manner, may be applied to carrier crystals of the same or another acid. The mixture is preferably pressed to give tablets. The acid provided for the embedding or covering may contain 0.1 to 3 mg of ethylenediaminetetraacetic acid per tablet.Type: GrantFiled: April 15, 1994Date of Patent: June 18, 1996Assignee: Gerhard GergelyInventors: Gerhard Gergely, Thomas Gergely, Irmgard Gergely
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Patent number: 5521222Abstract: Ophthalmic pharmaceutical vehicles which become viscous on contacting the eye are disclosed. Ophthalmic compositions of the vehicle and a pharmaceutically active drug are also disclosed.Type: GrantFiled: December 14, 1994Date of Patent: May 28, 1996Assignee: Alcon Laboratories, Inc.Inventors: Yusuf Ali, Kenneth W. Reed
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Patent number: 5518986Abstract: The present invention provides an effective method for controlling foliage and root fungus infection in cultivated crops. A fungicide composition in the form of an aqueous formulation which is applied to pre-harvest crops contains ingredients such as pentachloronitrobenzene, sodium bicarbonate, sodium carbonate, potassium oleate, potassium octanoate and xanthan gum. The combination of potassium oleate, potassium octanoate and xanthan gum functions as an effective spreader-sticker medium for forming an adherent coating on plant foliage surfaces, and for saturating ground soil. The coating exhibits both immediate and long duration fungicidal activities.Type: GrantFiled: April 6, 1995Date of Patent: May 21, 1996Assignee: Church & Dwight Co., Inc.Inventor: Anthony E. Winston
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Patent number: 5518987Abstract: The present invention provides an effective method for controlling foliage and root fungus infection in cultivated crops. A fungicide composition in the form of an aqueous formulation which is applied to pre-harvest crops contains ingredients such as etridiazole, potassium bicarbonate, sodium carbonate, potassium oleate, potassium caprylate and xanthan gum. The combination of potassium oleate, potassium caprylate and xanthan gum functions as an effective spreader-sticker medium for forming an adherent coating on plant foliage surfaces, and for saturating ground soil. The coating exhibits both immediate and long duration fungicidal activities.Type: GrantFiled: October 3, 1995Date of Patent: May 21, 1996Assignee: Church & Dwight Co., Inc.Inventor: Anthony E. Winston
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Patent number: 5510114Abstract: A slow-release pharmaceutical composition containing a bile acid as active ingredient and comprising at least one bioadhesive substance and at least one high specific gravity substance, an aliquot thereof being enteric coated and the remainder being non-enteric coated.Type: GrantFiled: May 2, 1994Date of Patent: April 23, 1996Assignee: Instituto Biochimico Italiano Giovanni Lorenzini S.p.A.Inventors: Fabio Borella, Alberto Brandt, Fabio Carli
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Patent number: 5508041Abstract: The invention relates to a microencapsulated emulsion a drug-dispersed oil core surrounded by a water-insoluble capsule material. The capsule material is made up of a polysaccharide which has metal chelating capacity, a biocompatible and water-soluble polymer for improving the physical properties of the capsule material, and emulsifying agents. The ratio of polysaccharide to polymer in the capsule material is at least capsule material, and emulsifying agents. The ratio of polysaccharide to polymer in the capsule material is at least 0.25.Type: GrantFiled: August 2, 1994Date of Patent: April 16, 1996Assignee: Korea Research Institute of Chemical TechnologyInventors: Haibang Lee, Soonhong Yuk
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Patent number: 5496568Abstract: The present invention provides an effective method for controlling foliage and root fungus infection in cultivated crops. A fungicide composition in the form of an aqueous formulation which is applied to pre-harvest crops contains ingredients such as propiconazole, sodium bicarbonate, potassium bicarbonate, sodium oleate, sodium caprylate and xanthan gum. The combination of sodium oleate, sodium caprylate and xanthan gum functions as an effective spreader-sticker medium for forming an adherent coating on plant foliage surfaces, and for saturating ground soil. The coating exhibits both immediate and long duration fungicidal activities.Type: GrantFiled: June 26, 1995Date of Patent: March 5, 1996Assignee: Church & Dwight Co., Inc.Inventor: Anthony E. Winston