Abstract: The invention relates to oligofluorinated coatings and their use in drag delivery The oligofluorinated coatings are compositions comprising formula (XVII). These coatings are used in a method of delivering a biologically active agent to a tissue surface in a mammalian tissue This method occurs by contacting the surface with the coating including an oligofluorinated oligomer and a biologically active agent wherein the coating resides on the tissue surface and release the biologically active agent to the tissue surface.

Abstract: Chewable sustained release compositions and their methods of production are provided. The sustained release compositions contain amphipathic lipids, which are used to encapsulate various drugs and active ingredients.

Abstract: There is provided a method of producing a composition having a continuous phase and a disperse phase dispersed finely with low polydispersity in the continuous phase, with high production efficiency. The composition is produced by the production method including the steps of: (A) passing the swirling flow of the continuous phase liquid into a cylindrical body the circumferential surface of which is either in part or entirely formed by a porous membrane, (B1) supplying the disperse phase fluid to the swirling flow via the porous membrane to form the particles of the disperse phase on the porous membrane, and (B2) detaching the disperse phase particles formed on the porous membrane by the shear force of the swirling flow.

Abstract: The present invention is directed to cationic nanoparticles, methods to make them, and the use of compositions containing said nanoparticles in personal care compositions or formulations. The nanoparticles are useful in personal care applications and impart antimicrobial properties to home and personal care products containing them. These cationic nanoparticles also contribute useful conditioning properties to hair-care and skin-care products.

Abstract: A lipid particle can include a cationic lipid. Synthesis of the cationic lipid can include a ylide-based reaction, such as a Wittig reaction or sulfur ylide reaction. In some cases, the synthesis can also include a Michael addition or a related addition reaction.

Abstract: Disclosed are organogels comprising selected amounts of 12-hydroxystearic acid gelator, cosmetically acceptable oil, a copolymer that carries at least 70% by weight of the copolymer of pendant alkyl groups having chain length of C12-C24, and, optionally, co-structurant; also disclosed are cosmetic compositions that comprise such organogels.

Abstract: The invention is a gel composition for delivery to a breast milk duct prior to surgical excision of breast tissue including cancerous lesions. The invention also provides methods of mapping all or nearly all of a breast milk duct prior to surgical excision of breast tissue, and method of identifying part or all of a breast duct or ducts as a surgical aide to a breast surgeon. Kits to support these methods and including these compositions are also provided.

Abstract: Methods and compositions for reducing the frequency of urination are disclosed. One method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising an analgesic agent formulated in a delayed-release formulation. Another method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising multiple active ingredients. Yet another method comprises administering to a subject in need thereof an effective amount of a diuretic followed with another administration of an pharmaceutical composition comprising an analgesic agent.

Abstract: Different components of natural oils are separated by forming solid complexes of components of the natural oil with a solvent, and then separating the solid complexes from the remaining liquids. The natural oil is cooled in the presence of a solvent, and at least one component of the oil forms the solid complex with the solvent. This solid complex is separated from the remaining liquid portion of the oil solution, which also contains the solvent. Additional options concentration steps can further concentrate the components left in the liquid phase.

Abstract: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

Abstract: Disclosed is a composition comprising an organogel which comprises: (a) an alkylated benzimidazolone compound; and (b) an organic liquid.

Abstract: The present invention relates to a thermogelling pharmaceutical composition comprising local anaesthetics in base form and which is suitable for topical administration. The compositions further comprise a polyoxyethylene castor oil and one or more surfactants to obtain thermogelling characteristics.

Abstract: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

Abstract: An in situ film-forming methyl acetate-based solution of at least one absorbable, segmented block copolymer with amorphous and semi-crystalline segments contains at least one bioactive agent which exhibits antimicrobial, anti-inflammatory, antiviral, anesthetic, hemostatic, and/or antineoplastic activity. The absorbable polymers can be a polyaxial copolyester, polyether-ester and polyether-ester urethane. The solution can be applied (e.g., sprayed or swabbed) onto animal and human skin or accessible body cavities to prevent or treat one or more disorders preventable or treatable by the bioactive agent therein.

Abstract: The present invention relates to a process for the preparation of an ester in a reactor, wherein at least one of at least two different catalysts is an electron donor and a further catalyst is a sulphur-containing proton donor; a device, a process for the preparation of a thermoplastic composition comprising the ester prepared according to the invention, a process for the production of a shaped article comprising the ester according to the invention or the thermoplastic composition according to the invention, a process for the production of a packed product, a process for the production of an at least partly coated object, and uses of the esters according to the invention as an additive in various compositions.

Abstract: Radiopharmaceutical compositions, and related methods, useful for medical imaging are provided. The radiopharmaceutical compositions include one or more radiopharmaceutical compounds, together with a stabilizer comprising ascorbic acid, wherein the pH of said composition is within the range of about 3.5-5.5.

Abstract: The present invention provides edible compositions comprising a compound of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of NaCl in a food product, methods of reducing the sodium intake in a diet, and methods of reducing bitter taste in a food product.

Abstract: A polymer compound according to the invention comprises an acrylic acid copolymer composed of acrylic acid derivatives and/or methacrylic acid derivatives, containing: a) at least one acrylic acid derivative and/or methacrylic acid derivative substituted with a sulfonic acid group; b) at least one hydrophilically substituted acrylic acid derivative and/or methacrylic acid derivative; c) at least one lipophilically substituted acrylic acid derivative and/or methacrylic acid derivative; and d) at least one acrylic acid derivative and/or methacrylic acid derivative which acts as a crosslinking agent.

Abstract: A composition comprising ethylhexyl methoxycrylene, a compound with multiple phenyl groups, and a carrier oil is provided. The composition may also include an organic sunscreen. The combination exhibits an unexpected synergistic effect, in that the photoactive properties of the composition (e.g., SPF, UV absorption) are significantly higher than would be predicted based on the values for each of the components individually.

Abstract: A microparticle for drug delivery comprises an active agent and an excipient, the excipient comprising a metal ion-lipid complex. The metal ion is chosen from the group consisting of lanthanide metals, actinide metals, group IIa and IIIb metals, transition metals or mixtures thereof. The lipid comprises a phospholipid. The complex results in a glass transition temperature increase of the microparticle.

Abstract: The present invention provides edible compositions comprising a compound of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of NaCl in a food product, methods of reducing the sodium intake in a diet, and methods of reducing bitter taste in a food product.

Abstract: Cosmetic or dermatological emulsions having a content of one or more acyl arginates of formula (I), where R and R2 independently of each other can be H and C5-22-alkyl, in particular formula (II) or formula (III), wherein said acyl arginates can also be present as salts, for example hydrochlorides.

Abstract: A tamper resistant drug delivery system made of at least one lipid, at least one gelling agent and at least one sympathomimetic amine, such as for example pseudoephedrine, wherein the system gels in the presence of water or a solution containing water and ethanol, wherein the sympathomimetic amine releases into the digestive system when ingested, and wherein the weight ratio of gelling agent to lipid is less than 1:1.4.

Abstract: The present invention relates to a process for preparing a multiple emulsion, particularly a water-in-oil-in-water emulsion in a single step using a single non ionic hydrophilic emulsifier that stabilizes the multiple emulsion for a period of one month. Further, the process uses low levels of a single emulsifier that makes the multiple emulsion find its application in any cosmetic, pharmaceutical and food industry catering to the specificity of the quantity of the emulsifier permissible within a particular industry and also acknowledging the quality of the final product required to be obtained for subsequent application and use thereof.

Abstract: Described herein are compositions (e.g., a pharmaceutical composition) and methods for controlling the delivery of a therapeutic agent, and their use in the treatment and/or prevention of diseases and disorders.

Abstract: A system for preparing a polyphenol containing formulation includes a first component which is a polyphenol and a second component which is the solvent system for the polyphenol. The solvent system includes water and a surfactant which is an ester of a dicarboxylic acid. The components are maintained separately from one another and are mixed prior to use. Specific compositions prepared through the use of the system include polyphenols and a solvent system based upon diaryl sulfosuccinate salts, water and optional glycols together with ancillary ingredients such as buffers, preservatives, coloring agents, fragrances, and thickeners.

Abstract: Abuse-resistant oral dosage forms suitable for administration of pharmacologically active agents are provided.

Abstract: The present invention relates to oligoesters and their use for the creation of additives. Oligoester containing additives and/or oligoesters themselves may be used for formulating pharmaceutical preparations, cosmetics or personal care products such as shampoos and conditioners. These oligoesters are particularly useful for the creation of multi-purpose additives that can impart conditioning, long substantivity and/or UV protection. Individual oligoesters and oligoester mixtures are described.

Abstract: The present invention primarily relates to the use of one or a plurality of neoflavonoids of formula (I) and/or one or a plurality of physiologically acceptable salts of one or a plurality of neoflavonoids of formula (I) for producing a sensory impression of sweetness (i.e. an impression of sweetness) in an orally consumable preparation or for intensifying the sensory impression of sweetness of an orally consumable preparation comprising at least one further sweet-tasting and/or sweet-smelling substance. The present invention further relates to certain semifinished products and certain orally consumable preparations containing one or a plurality of neoflavonoids of formula (I) and/or one or a plurality of physiologically acceptable salts of one or a plurality of neoflavonoids of formula (I). Finally the invention also relates to a method of producing an orally consumable preparation and a method of producing and/or intensifying a sensory impression of sweetness in/of an orally consumable preparation.

Abstract: The present application is directed to lipid-drug complexes and related methods for producing stable lipid-drug complexes at or near the neutral pH range and administering pharmaceutical lipid-drug complexes to patients. In certain examples, the lipid-drug complex has a lipid-to-drug molar ratio of approximately 3:1. In certain examples, the lipid-drug complex may have lipid-to-drug molar ratios of less than 3:1 to 10:1 or higher. The present application is also directed to methods of administering a drug to a patient though subcutaneous injection of the lipid-drug complexes into particular tissues to effect higher localized concentrations of the at least one drug.

Abstract: The present invention relates primarily to the use of one or a plurality of neoflavonoids of formula (I) and/or one or a plurality of physiologically acceptable salts of one or a plurality of neoflavonoids of formula (I) for flavor modification, in particular for altering or masking a bitter, astringent and/or metallic flavor impression of a bitter, astringent and/or metallic tasting substance and a corresponding method of flavor modification. The present invention further relates to certain mixtures and certain preparations fit for consumption containing one or a plurality of neoflavonoids of formula (I) and/or one or a plurality of physiologically acceptable salts of one or a plurality of neoflavonoids of formula (I).

Abstract: Particles having a tap density of less than 0.4 g/cm3 include a hydrophobic amino acid or salt thereof and a therapeutic, prophylactic or diagnostic agent or any combination thereof. Preferred particles include a phospholipid, have a median geometric diameter between about 5 and about 30 microns and an aerodynamic diameter between about 1 and about 5 microns. The particles can be formed by spray-drying and are useful for delivery to the pulmonary system.

Abstract: The invention relates to novel quaternary ammonium compounds of the esterquat type, to a method for the production thereof, and to the use thereof in formulations.

Abstract: Presented are methods of using topical analgesic compositions for rapid relief of muscular aches and pain where the analgesic composition has been stored at a temperature of less than 10° Centigrade prior to use.

Abstract: Provided is a novel oily material that spreads smoothly upon application and is free from stickiness, and also gives ungreasy and moisturized feeling after application, but does not give friction feeling peculiar to silicone. The invention was completed upon finding that a specific acyl acidic amino acid monosilicone monosterol ester can solve the foregoing problems.

Abstract: This invention relates to the discovery of functionalized triclosan monomers and oligomers that, when incorporated into a substrate of, or applied as part of a coating to, medical devices and/or consumer products may extend the duration of antimicrobial properties to the medical devices and/or consumer products.

Abstract: Estolide compounds that may be suitable for use in personal care and cosmetic formulations, and method of preparing the same. The estolides can be tailored to exhibit the desired viscometric and lubricity properties, while retaining or even improving other properties desirable in such products.

Abstract: The invention relates to the use of at least one specific triazine or melamine and/or salt thereof as accelerator for a photoinduced reaction of 3-(4-tert-butylphenyl)-3-hydroxy-1-(4-methoxyphenyl)-propan-1-one, 1-(4-tert-butylphenyl)-3-hydroxy-3-(4-methoxyphenyl)-propan-1-one or a mixture of these compounds to give avobenzone. The invention furthermore relates to a composition comprising at least one specific triazine or melamine and to a method for the stabilisation of the UV absorption capacity of a composition by means of a mixture of at least one specific triazine or melamine together with 3-(4-tert-butylphenyl)-3-hydroxy-1-(4-methoxyphenyl)propan-1-one, 1-(4-tert-butylphenyl)-3-hydroxy-3-(4-methoxyphenyl)propan-1-one or a mixture of these compounds, particularly preferably together with 3-(4-tert-butylphenyl)-3-hydroxy-1-(4-methoxyphenyl)propan-1-one.

Abstract: Perfume compositions having functional perfume components for aiding in perfume evaporation. The functional perfume components have a Kovat's index in the range of 900-1400 and an ODT of greater than about 1 ppb. In one embodiment, the functional perfume component may be present in an amount from at least about 10% by weight of the composition. In another embodiment, the composition containing a function perfume component is substantially free of a VOC.

Abstract: The present invention provides an ophthalmic composition comprising a hyperbranched polyester. The ophthalmic compositions may also comprise carbonic anhydrase inhibitors, wherein the hyperbranched polyester increases the aqueous solubility of the carbonic anhydrase inhibitor, and increases corneal permeation of the active agent. The ophthalmic compositions may also comprise non-ionic surfactants, such as PEG, Polysorbate, HPMC or HEC, and beta-blockers, such as Carteolol, Levobunolol, Betaxolol, Metipranolol, Timolol or Propranolol. The concentration of the hyperbranched polyester in the ophthalmic formulation should be less than or equal to 4% (w/v) in order to avoid any cytotoxic effects on human corneal cells and thus the eye irritation.

Abstract: The invention relates to an additive comprising at least 95 wt. % of a mixture consisting of at least one organic filter filtering UVA, at least one organic filter filtering UVB, and from 1 to 50 wt. % of at least one non-volatile oil that is a solvent for said filters. This composition is particularly useful as an agent for protecting the organoleptic properties of a transparent cosmetic composition, against UV radiation.

Abstract: A cosmetic raw material comprising the following components (A), (B), and (C): (A) a specific polyether-modified organopolysiloxane; (B) a chain-form silicone oil that is a liquid at 25° C., does not contain a cyclic structure, and does not contain a resinous structure; and (C) an oil that is a liquid at 30° C. and that characteristically (c1) has at least one hydroxyl group in each molecule, (c2) has from 0 to 3, as the number of moles of addition, oxyethylene units in each molecule, (c3) has an HLB value in the range from 0.1 to 6.0, and (c4) has an average molecular weight in the range from 200 to 7000.

Abstract: The present invention relates to dephenolic compounds, an example of which is shown below, which are functionalized, and polymers formed from the same. Polymers formed from the functionalized diphenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.

Abstract: The present invention relates to a process for the preparation of an ester in a reactor, wherein at least a portion of the process components is led in a delivery stream outside the reactor over a heat transfer surface as a film, the ratio of the delivery stream to the heat transfer surface being in a range of from 0.25 to 3 m/h, a device, a process for the preparation of a thermoplastic composition comprising the ester prepared according to the invention, a process for the production of a shaped article comprising the ester according to the invention or the thermoplastic composition according to the invention, a process for the production of a packed product, a process for the production of an at least partly coated object, and uses of the esters according to the invention as an additive in various compositions.

Abstract: The invention relates to novel compounds of dibenzylidene sorbitol ester type corresponding to the following formulae (I) and (II): in which: R, R? and R? represent a hydrogen atom or a —C(O)Y radical in which Y represents a C2-C25 hydrocarbon radical or an optionally substituted aryl radical; the R1, R2, R3, R4, R5, R?1, R?2, R?3, R?4 and R?5 radicals represent a hydrogen atom; a C1-C18 alkyl radical; a C1-C18 alkoxy radical; a phenoxy radical; an optionally substituted phenyl radical; or a benzyl radical; the divalent radical A represents, in the formula (II), a C1-C52 hydrocarbon radical; an optionally substituted arylene radical; or a silicone radical. The invention also relates to their process of preparation, to their use in structuring lipophilic media, in particular oils, to the cosmetic or pharmaceutical compositions comprising them and to a cosmetic treatment method employing them.

Abstract: This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperatures ranging from cold to body temperature for long periods of time. The formulations are capable of being uniformly delivered from drug delivery systems at an exit shear rate of between about 1 to 1×10?7 reciprocal second.

Abstract: Reverse hexagonal mesophase (HII) liquid crystals are provided and relating therapeutic and non-therapeutic applications are demonstrated.

Abstract: The present invention relates to compounds of formula I and II, which are functionalized amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.

Abstract: An apparatus, system, and method are disclosed for encapsulating a homeopathic ingredient with a second ingredient. A homeopathic carrier is prepared by applying the homeopathic ingredient to at least one element. The element is selected from the second ingredient, an excipient, and a capsule assembly. The second ingredient is encapsulated in a closed capsule assembly. The closed capsule assembly comprises the homeopathic carrier.

Abstract: The present invention relates to novel compounds and their use in fragrance compositions. Novel 3.2.1-bicyclo-octene and -octane compounds of the present invention are represented by formula: wherein R is selected from the group consisting of hydrogen, acetate, carbonate monomethyl ester, and allyloxy; and wherein the broken line represents a single or double bond.