Hair Treatment (therapeutic-scalp) Patents (Class 514/880)
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Patent number: 5026691Abstract: This invention relates to the method for treating human baldness, including the form of alopecia commonly known as "male pattern baldness", which comprises regular topical application to the affected areas of the human scalp of minoxidil and an anti-inflammatory agent.Type: GrantFiled: September 29, 1989Date of Patent: June 25, 1991Assignee: The Upjohn CompanyInventor: Albert M. Kligman
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Patent number: 5023246Abstract: Betain group-containing derivatives of carboxymethylcellulose are disclosed. They are characterized in that all or a portion of the carboxymethyl groups are or is replaced by groups of the general formula ##STR1## wherein R.sup.1 is hydrogen or methyl group,R.sup.2 is a divalent aliphatic hydrocarbon group with 2 to 5 carbon atoms,R.sup.3, R.sup.4 is an alkyl group with 1 to 4 carbon atoms,R.sup.5 is a divalent aliphatic hydrocarbon group with 1 to 10 carbon atoms,with the proviso that, on the average, at least 0.1 betaine groups are contained for each anhydroglucose unit of the polymeric molecule.Also, a method for the synthesis of these compounds and their use in cosmetic preparations, especially for the care of hair, are disclosed. In addition, novel derivatives of carboxymethylcellulose with tertiary amino groups are taught as intermediates. In these derivatives, all or a portion of these groups are or is replaced by groups of the general formula ##STR2## in which the substituents R.sup.1, R.sup.2, R.sup.Type: GrantFiled: May 17, 1989Date of Patent: June 11, 1991Assignee: Th. Goldschmidt AGInventors: Burghard Gruning, Klaus Hoffmann, Gotz Koerner, Hans-Joachim Kollmeier
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Patent number: 5006337Abstract: Medicinal and cosmetic compositions for the treatment of skin disorders and for care of dry and/or irritated skin and of dry scalp with dandruff are prepared using brewers' grains extract(s)--especially a brewers' grains extract obtained using liquid or above-critical CO.sub.2 or N.sub.2 O.Type: GrantFiled: April 14, 1988Date of Patent: April 9, 1991Assignee: Marbert GmbHInventors: Lothar Motitschke, Hagen Tronnier
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Patent number: 5000961Abstract: The invention relates to benzylidenecamphor derivatives of formula: ##STR1## where R is hydrogen or a tert-butyl residue, R.sub.1 is a C.sub.1 -C.sub.8 alkyl or alkoxy residue, and R.sub.2 and R.sub.3 denote hydrogen or hydroxyl, at least one of the two being hydroxyl, to a process for preparing them and to their uses as antioxidants, broad-band sunscreens and medicinal products for the preventive treatment of skin allergies and inflammations as well as for the prevention of certain cancers.Type: GrantFiled: May 23, 1990Date of Patent: March 19, 1991Assignee: L'OrealInventors: Gerard Lang, Serge Forestier, Alain Lagrange, Claudine Moire, Andre Deflandre
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Patent number: 5001156Abstract: Lipophilic quaternary ammonium salicylate, characterized in that it corresponds to the formula: ##STR1## in which: (i) R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be identical or different, denote an alkyl or alkylcycloalkyl radical, optionally substituted or interrupted;(ii) R.sub.3 and/or R.sub.4 denote(s) a group:R.sub.8 [OC.sub.2 H.sub.3 R.sub.7 ].sub.n [OCH.sub.2 CHOH--CH.sub.2 ].sub.pin which 0.ltoreq.n.ltoreq.4 and p denotes 0 or 1; R.sub.8 denotes H or an alkyl, alkenyl, alkylcycloalkyl or alkylaryl radical;(iii) R.sub.4 denotes an alkylphenyl radical;(iv), (v) R.sub.1 and R.sub.2 can form a saturated or unsaturated aromatic or non-aromatic heterocycle;(vi) R.sub.1, R.sub.2 and R.sub.3 form polycyclic derivatives with the nitrogen atoms; R.sub.5 denotes a group corresponding to the formula: ##STR2## in which n is an integer varying between 0 and 10.Type: GrantFiled: December 1, 1987Date of Patent: March 19, 1991Assignee: L'OrealInventors: Michel Philippe, Henri Sebag, Michel Hocquaux, Bernard Jacquet, Jean P. Laugier
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Patent number: 4999195Abstract: Personal care products comprising bioemulsifiers, for example, those produced by Acinetobacter calcoaceticus, are provided. Use of such personal care products result in beneficial effects to skin and hair.Type: GrantFiled: July 5, 1989Date of Patent: March 12, 1991Assignee: Emulsan Biotechnologies Inc.Inventor: Michael E. Hayes
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Patent number: 4996057Abstract: The object of the invention is a composition for the local treatment of the epidermis comprising at least two active constituents, characterized in that one of these constituents is a product resulting from the condensation of N-methyl-p-methoxyphenethylamine with formaldehyde or product of the aromatic polyamine-type. It particularly relates to a composition for treating the scalp, particularly for treating alopeciae and alopecia aerata or pelada comprising, as second active constituent, a placental extract containing proteinic compounds and sulfurized amino acids. Application to the treatment of the epidermis, particularly of the scalp.Type: GrantFiled: January 24, 1989Date of Patent: February 26, 1991Assignee: Nadine SchoeffInventors: Nadine Schoeff, Jean-Pierre Poujol, deceased
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Patent number: 4996196Abstract: There are disclosed a novel desiccant containing anhydrous maltose and dehydration of hydrous matters, e.g. food, pharmaceutical and cosmetic, therewith. Such hydrous matters are dehydrated without causing alteration or deterioration by incorporating anhydrous maltose into the hydrous matters to convert the anhydrous maltose into crystalline beta-maltose hydrate. The anhydrous maltoses usable in the invention are anhydrous crystalline alpha-maltose, anhydrous crystalline beta-maltose and anhydrous amorphous beta-maltose, specifically, those in pulverulent form.Type: GrantFiled: July 21, 1989Date of Patent: February 26, 1991Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Masakazu Mitsuhashi, Shuzo Sakai, Toshio Miyake
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Patent number: 4988806Abstract: Derivatives of carboxymethylcellulose are disclosed in which all or a portion of the carboxymethyl groups are replaced by groups of the general formula ##STR1## in which R.sup.1 is a hydrogen or methyl group,R.sup.2 is a divalent aliphatic hydrocarbon group with 2 to 5 carbon atoms,R.sup.3, R.sup.4 are alkyl groups with 1 to 4 carbon atoms,R.sup.5 is an alkyl group with 1 to 4 carbon atoms or a benzyl group,X is a halogen or sulfate group or a sulfonic acid group,with the proviso that, on the average, at least 0.1 quaternary ammonium groups are contained per anhydroglucose unit of the polymeric molecule.The invention furthermore relates to derivatives of carboxymethylcellulose, in which all or a portion of the carboxymethyl groups are replaced by groups of the general formula ##STR2## in which the substituents R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the above meaning, with the proviso that, on the average, at least 0.Type: GrantFiled: June 13, 1989Date of Patent: January 29, 1991Assignee: Th. Goldschmidt AGInventors: Burghard Gruning, Klaus Hoffmann, Gotz Koerner, Hans-Joachim Kollmeier
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Patent number: 4985464Abstract: A drug composition for the local treatment of alopecia areata and other dermatological diseases is disclosed. The composition contains as an active ingredient an aliphatic, alkoxy or aryl substituted cyclopropenone. Diphenylcyclopropenone is a particularly preferred representative cyclopropenone useful in the context of the present invention.Type: GrantFiled: January 22, 1985Date of Patent: January 15, 1991Inventors: Rudolf Happle, Bjorn Hausen
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Patent number: 4985425Abstract: A dissolved composition containing (A) one or more of [benzo-1,2,4-thiadiazine]-1,1-dioxide derivatives, (B) dimethyl sulfoxide, benzyl alcohol, or the mixture thereof; (C) water; and (D) one or more anionic surfactants and/or surfactants, other than anionic surfactants, having a nitrogen atom in the molecule thereof, or (D') n-decylmethyl sulfoxide, or (D") (i) one or more ampholytic surfactants and/or nonioni-cationic-polar surfactants and (ii) one or more nonionic surfactants having a nitrogen atom in the molecule thereof and, optionally, (E) isopropyl alcohol and (F) a pH controller.This dissolved composition is effective as an ingredient for a hair germination and hair growth promoting agent.Type: GrantFiled: January 21, 1988Date of Patent: January 15, 1991Assignee: Shiseido Company Ltd.Inventors: Tadahiro Chiba, Kiyoshi Miyazawa, Makoto Uzuka, Takashi Suzuki
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Patent number: 4968685Abstract: The invention relates to a composition for inducing and stimulating hair growth and retarding its loss, containing, in a cosmetically or pharmaceutically acceptable medium, at least one pyrimidine derivative corresponding to the formula (I): ##STR1## in which R.sub.1 denotes a group ##STR2## in which R.sub.3 and R.sub.4 can be chosen from hydrogen, an alkyl group preferably having 1 to 4 carbon atoms, and an alkenyl, alkylaryl or lower cycloalkyl group, and R.sub.3 and R.sub.4 can also form a heterocyclic ring with the nitrogen atom to which they are attached, it being possible for this heterocyclic ring to be chosen, inter alia, from aziridinyl, azetidinyl, pyrrolidinyl, piperidyl, hexahydroazepinyl, heptamethyleneimine, octamethyleneimine, morpholine and 4-(lower alkyl)piperazidinyl groups, it being possible for the heterocyclic groups to be substituted on the carbon atoms with one to three lower alkyl, hydroxyl or alkoxy groups; the group R.sub.Type: GrantFiled: September 8, 1987Date of Patent: November 6, 1990Assignee: L'OrealInventor: Jean F. Grollier
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Patent number: 4963591Abstract: Skin care cosmetic formulations which include a cellulosic polymer/solvent system capable of dispersing thin, substantive films on the skin are disclosed.Type: GrantFiled: December 16, 1985Date of Patent: October 16, 1990Assignee: Carter-Wallace Inc.Inventors: Robert G. Fourman, Richard P. Dixon, Hans Breuer
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Patent number: 4961922Abstract: A complex based on anthralin and a sterol, characterized in that its melting point is 10 to 25 degrees Celsius lower than that of the constituent of the complex melting at the lowest temperature and that the proportion of anthralin varies between 10 and 90 mol %.Type: GrantFiled: April 13, 1989Date of Patent: October 9, 1990Assignee: Centre International De Recherches DermatolociquesInventors: Braham Shroot, Daniele Caron, Jean-Claude Caron, Alain Brzokewicz
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Patent number: 4957744Abstract: Cross-linked esters of hyaluronic acid are provided which result from the esterification of polyhydric alcohols with two or more carboxy groups of the hyaluronic acid polysaccharide. These cross-linked esters are useful in the field of biodegradable plastics for sanitary and surgical articles and in the pharmaceutical and cosmetic fields for the preparation of useful compositions and articles.Type: GrantFiled: October 13, 1987Date of Patent: September 18, 1990Assignee: Fidia, S.p.A.Inventors: Francesco della Valle, Aurelio Romeo
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Patent number: 4957742Abstract: Platelet enriched plasma is produced from blood. The platelets are activated by thrombin which causes the release of platelet-derived growth and angiogenesis factors. A carrier such as a microcrystalline collagen is added to produce a wound-treating salve. The composition is applied directly to wounds and initiates healing in nonhealing wounds as well as accelerating normal wound-healing by increasing vascularization, stimulating fibroblast mitosis and migration, and increasing collagen synthesis by fibroblasts. The composition is also applied to tissue to facilitate the growth of hair.Type: GrantFiled: January 10, 1989Date of Patent: September 18, 1990Assignee: Regents of the University of MinnesotaInventor: David R. Knighton
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Patent number: 4954532Abstract: A degreasing or moisturizing composition contains silanized silica gel, a humectant such as glycerine, and an inert carrier. The composition is used to treat sebhorreic conditions without causing dry skin.Type: GrantFiled: January 30, 1985Date of Patent: September 4, 1990Assignee: Beecham Group p.l.c.Inventors: Thomas J. Elliott, Susan Dutton
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Patent number: 4950467Abstract: Sunscreen compositions are described which contain certain 5-phenylpentadienoate esters which act as UV filters when incorporated in a carrier in amounts ranging from 0.1-50% by weight.Type: GrantFiled: November 14, 1986Date of Patent: August 21, 1990Assignee: ICI Americas Inc.Inventors: Charalambos J. Phalangas, Alfred J. Restaino, Lau S. Yang
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Patent number: 4948576Abstract: This invention relates to detergent compositions comprising at least one surfactant, at least one water-soluble nitrogen-containing polymer and a water-soluble, non-particulate substance capable of imparting a desired residual effect to a specific substrate such as the scalp or skin.Type: GrantFiled: February 18, 1983Date of Patent: August 14, 1990Assignee: Johnson & Johnson Consumer Products, Inc.Inventors: Robert J. Verdicchio, Diane L. Spilatro
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Patent number: 4948583Abstract: A cosmetic composition for the treatment of hair, in particular oily hair. The composition includes an appropriate carrier and a non-allergenic dry extract of yarrow (Achillea millefolium L), obtained by oxidation of a water-alcohol solution extract of flower tops of yarrow. The extract contains less than 0.5% by weight of polyphenolic derivatives.Type: GrantFiled: April 21, 1989Date of Patent: August 14, 1990Assignee: Societe Anonyme dite : l'OrealInventors: Jean-Francois Grollier, Georges Rosenbaum
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Patent number: 4945093Abstract: A compound having formula: ##STR1## is described, where R.sub.3 and R.sub.4 may be identical or different and represent a hydrogen atom, alkyl, alkenyl, cycloalkyl;or R.sub.3 and R.sub.4 represent aryl aralkyl;or R.sub.3 and R.sub.4 together with the nitrogen atom linked thereto form a heterocycle;R.sub.1 and/or R.sub.2, independent of each other, represent hydrogen or carbanoyl having formula: ##STR2## where R.sub.7 represents alkyl, alkenyl, cycloalkyl, aryl or aralkyl. The compounds of formula (I) can be used in cosmetic or pharmaceutical compositions for the cosmetic treatment of hair, the treatment of alopecia, and also for the treatment of desquamating dermatitis.Type: GrantFiled: July 29, 1988Date of Patent: July 31, 1990Assignee: L'OrealInventors: Jean Maignan, Serge Restle, Gerard Lang
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Patent number: 4942038Abstract: A new humectant for animal care product use having a moisturizer encapsulated in a lipid vesicle has been developed. The humectant is particularly useful as an additive to shampoos or cream rinses.Type: GrantFiled: August 19, 1988Date of Patent: July 17, 1990Assignee: Micro Vesicular Systems, Inc.Inventor: Donald F. H. Wallach
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Patent number: 4941885Abstract: The subject invention enables a more efficient management of hair by providing a novel preparation for waving, straightening, softening, or removing hair, employing as a key ingredient the compound thioredoxin or a thioredoxin-derived, or thioredoxin-like, dithiol peptide in combination with thioglycolic acid compounds. This invention allows hair to be treated at a lower pH to minimize hair damage when waving, straightening, or softening the hair; when used to remove hair, objectionable odors of commercial depilatories are minimized or eliminated.Type: GrantFiled: September 14, 1989Date of Patent: July 17, 1990Assignee: Repligen CorporationInventor: Vincent P. Pigiet
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Patent number: 4942174Abstract: Novel alkyl aryl ether derivatives corresponding to the formula: ##STR1## in which R.sup.1 is a C.sub.8 -C.sub.20 alkyl group with one or more branches, E is a group --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH-- and R.sup.2 is a C.sub.1 -C.sub.4 alkyl group, a C.sub.2 -C.sub.4 hydroxyalkyl group, an alkoxyalkyl group containing 1 to 4 C atoms in the alkoxy group and 2 to 4 C atoms in the alkyl group, hydrogen or a salt-forming cation, are highly effective sebosuppressive agents in cosmetic or pharmaceutical preparations for topical application to the hair and to the skin.Type: GrantFiled: November 10, 1988Date of Patent: July 17, 1990Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Hinrich Moeller, Siegfried Wallat
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Patent number: 4940696Abstract: A benzonaphthalene compound has the formula ##STR1## wherein R.sub.1 represents ##STR2## or (ii) --CH.sub.2 OH; R.sub.6 represents ##STR3## or OR.sub.7 wherein R.sub.7 represents hydrogen, alkyl having 1-20 carbon atoms, monohydroxyalkyl or polyhydroxyalkyl, r' or r" represent hydrogen, lower alkyl, mono or polyhydroxyalkyl, aryl or a residue of an amino acid or a sugar, or together form a heterocycle; R.sub.2 represents hydrogen, alkyl having 1-15 carbon atoms, alkoxy having 1-4 carbon atoms or a cycloaliphatic radical; R.sub.3 represents hydrogen, hydroxy, alkyl having 1-4 carbon atoms, alkoxy having 1-10 carbon atoms, a cycloaliphatic radical, a thiocycloaliphatic radical or --O--Si(CH.sub.3).sub.2 --R.sub.8 wherein R.sub.8 represents lower alkyl; and R.sub.4 and R.sub.5 represent hydrogen, lower alkyl, hydroxy or lower acyloxy.This compound is useful in the topical and systemic treatment of dermatologic diseases and in the treatment of the degeneration of conjunctive tissues.Type: GrantFiled: November 16, 1987Date of Patent: July 10, 1990Assignee: Centre International de Recherches Dermatologioues (CIRD)Inventors: Braham Shroot, Jacques Eustache, Jean-Michel Bernardon
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Patent number: 4938950Abstract: A cosmetic composition is disclosed for the treatment of hair or skin, based upon 0.05 to 10% by weight of chitosan, and characterized by a content of 0.05 to 20% by weight of an ampholytic copolymerizate of formula (I) ##STR1## wherein m=0.5 to 0.9, n=0.1 to 0.5, m+n=1 and p being such that the ampholytic copolymerizate has a molecular weight of from 1,000 to 3,000,000.wherein m=0.1 to 0.9 and n=0.5 to 0.9. The composition provides clear, smooth films, which are neither sticky in moist climate, nor brittle in dry climate. Also disclosed are new chitosan/polyampholyte salts, obtained by reaction of chitosan with an ampholytic copolymerizate of formula (I).Type: GrantFiled: December 22, 1987Date of Patent: July 3, 1990Assignee: Wella AktiengesellschaftInventors: Guenther Lang, Harald Wendel
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Patent number: 4935240Abstract: A benzoylaminophenoxybutanoic acid derivative of general formula: ##STR1## [wherein A represents oxygen atom, sulfur atom or sulfinyl (SO) group,R.sup.1 represents hydrogen atom or methyl group,R.sup.2 represents a group of the general formula: ##STR2## {wherein B represents oxygen atom, sulfur atom or a group of general formula: NR" (wherein R" represents hydrogen atom or alkyl group of from 1 to 4 carbon atoms(s)), R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 represent, independently, hydrogen atom, alkyl group of from 1 to 4 carbon atom(s), halogen atom or trifluoromethyl group,m represents 0 or 1,n represents an integer of from 1 to 4, andR.sup.9 and R.sup.10 represent, independently, hydrogen atom, alkyl group of from 1 to 5 carbon atom(s) or a group of general formula: ##STR3## (wherein R.sup.12, R.sup.13, R.sup.14 and R.sup.15 represent, independently, hydrogen atom, alkyl group of from 1 to 4 carbon atom(s), halogen atom or trifluoromethyl group, and 1 represents an integer of from 1 to 4.Type: GrantFiled: May 6, 1988Date of Patent: June 19, 1990Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Hisao Nakai, Hiroshi Terashima, Yoshinobu Arai
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Patent number: 4933371Abstract: Method of treating animal hosts or their environment for ticks and fleas by applying thereto a toxic amount of linalool.Type: GrantFiled: August 23, 1988Date of Patent: June 12, 1990Assignee: Shirlo, Inc.Inventors: W. Fredric Hink, Thomas E. Duffey
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Patent number: 4933177Abstract: A cosmetic composition for the treatment of the hair and skin comprises at least 5 weight percent of pulverized particles of at least one plant. The particles have a granulometry lower than 125 microns. The compositions also includes a cohesion agent in an amount to maintain the homogeneity of the composition.Type: GrantFiled: June 15, 1988Date of Patent: June 12, 1990Assignee: Societe Anonyme dite: L'OREALInventors: Jean-Francois Grollier, Josiane Allec, Chantal Fourcadier, Georges Rosenbaum, Patrick Darmenton
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Patent number: 4931274Abstract: A composition for effectively treating dandruff, seborrheic dermatitis and scalp psoriasis comprising a combination of essential ingredients consisting of microfine particles of a clay mineral containing adsorbed magnesium, water, ethanol, sodium chloride and, optionally, minor amounts of glycerin and precipitated sulfur. The effectiveness of the method in treating such scalp diseases by topical application to the scalp epidermis is predicated on the capacity of the composition to release and deliver magnesium cations and hydroxyl anions to the causative sites and return the associated pathological cells to a normal morphology.Type: GrantFiled: August 17, 1988Date of Patent: June 5, 1990Assignee: Physiological Research AssociatesInventors: William A. Barabino, Robert J. Cross
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Patent number: 4931210Abstract: The present invention relates to a process for producing a W/O/W type multiple emulsion using a polyglycerol polyricinolate (i.e. a polyglycerol ester of a polycondensed fatty acid of castor oil).The use of the polyglycerol polyricinolate is effective in increasing the rate of formation of the W/O/W type multiple emulsion remarkably and giving a W/O/W type multiple emulsion which is stable over a long period of time. The W/O/W type multiple emulsion has also an excellent heat stability and is useful for the production of medicines and cosmetics.Type: GrantFiled: September 19, 1988Date of Patent: June 5, 1990Assignee: Menji Milk Products Company LimitedInventors: Yasuyuki Takahashi, Toshiro Yoshida, Takeshi Takahashi
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Patent number: 4925658Abstract: Aromatic esters and thioesters have the formula ##STR1## wherein X represents oxygen or sulfur,R.sub.1 represents --CH.sub.2 OH, --CH(OH)--CH.sub.3, --COOR.sub.5 or ##STR2## R.sub.5 represents hydrogen, lower alkyl, lower alkenyl, monohydroxyalkyl or polyhydroxyalkyl,r' and r" represent hydrogen, lower alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl or benzyl optionally substituted, the residue of an amino acid or aminated sugar, or taken together form a heterocycle,R.sub.2 represents .alpha.,.alpha.'-disubstituted alkyl having 4-12 carbon atoms or mono- or polycyclic cycloalkyl having 5-12 carbon atoms whose carbon linking carbon is trisubstituted,R.sub.3 represents hydrogen, lower alkyl, or --Si(CH.sub.3).sub.2 R'.sub.3 wherein R'.sub.3 represents lower alkyl, andR.sub.4 represents hydrogen or lower alkyl, andthe salts of these aromatic esters and thioesters of formula (I) when R.sub.5 represents hydrogen.Type: GrantFiled: January 19, 1989Date of Patent: May 15, 1990Assignee: Centre International De Recherches dermatologiques (CIRD)Inventors: Braham Shroot, Jacques Eustache, Jean-Michel Bernardon
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Cosmetic application of polysiloxanes containing a .beta.-keto ester group and compositions employed
Patent number: 4925659Abstract: Use in cosmetics of diorganopolysiloxanes containing a .beta.-keto ester group, corresponding to the formula: ##STR1## in which: the groups R, which may be identical or different, denote, independently of one another, a C.sub.1 -C.sub.4 alkyl, 3,3,3-trifluoropropyl, vinyl or phenyl groups, at least 80%, in numerical terms of the groups R being methyl radicals;the groups Y, which may be identical or different, denote, independently of one another, a C.sub.1 -C.sub.18 linear or branched alkylene link, optionally extended by a polyether chain;the groups X, which may be identical or different, denote, independently of one another, a radical Y--OH or Y--OCOR', Y having the meaning stated above and R' being chosen from C.sub.1 -C.sub.Type: GrantFiled: February 2, 1989Date of Patent: May 15, 1990Assignee: L'OrealInventors: Jean F. Grollier, Claude Dubief -
Patent number: 4920140Abstract: Aromatic heterocyclic derivatives have the formula ##STR1## wherein R.sub.1 represents (i)--CH.sub.3, (ii)--CH.sub.2 OH or (iii) ##STR2## wherein R.sub.3 represents hydrogen, --OR.sub.4 wherein R.sub.4 represents hydrogen, alkyl having 1-20 carbon atoms or mono- or polyhydroxyalkyl or R.sub.3 represents ##STR3## wherein r' and r" represent hydrogen, lower alkyl or together form a heterocycle, R.sub.2 represents hydrogen or --CH.sub.3 and Ar represents ##STR4## wherein R.sub.6 is hydrogen or alkyl having 1-10 carbon atoms and R.sub.7 represents alkyl having 4-12 carbon atoms or cycloalkyl, Y is CH or a nitrogen atom and X represents oxygen, sulfur or --N--R.sub.8 when R.sub.8 represents hydrogen, lower alkyl or lower alkoxycarbonyl, with the proviso that (i) when Y is CH and X is oxygen or sulfur Ar is other than C and (ii) when Y is nitrogen and X is oxygen, Ar is other than (C) or (D) in which R.sub.6 is alkyl having 1-4 carbon atoms and R.sub.7 is branched alkyl having 4-12 atoms.Type: GrantFiled: March 24, 1988Date of Patent: April 24, 1990Assignee: Centre International de Recherches Dermatologiques C.I.R.D.Inventors: Braham Shroot, Jacques Eustache, Jean-Michel Bernardon
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Patent number: 4916133Abstract: New 1-piperazinylpyrimidine derivatives, preparation thereof and application thereof in therapeutics and cosmetics.New compounds derived from 1-piperazinylpyrimidine derivatives, and their application in therapeutics and cosmetics, corresponding to the general formula: ##STR1## in which R represents an alkoxycarbonyl group containing from 1 to 3 carbon atoms in the alkoxy chain or alternatively a furoyl group, n being 0 or 1, and their addition salts with cosmetically or pharmaceutically acceptable acids.Type: GrantFiled: September 8, 1989Date of Patent: April 10, 1990Assignee: L'OrealInventors: Philippe Manoury, Jean F. Grollier
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Patent number: 4900544Abstract: An aqueous hair-treatment preparation containing an antistatic additive imparting an antistatic effect to the hair, characterized in that said antistatic additive is at least one cationic polymer produced by the process of (1) epoxidizing 1,3-diene homopolymers or copolymers (2) reacting the epoxide compound so produced with low molecular weight amines selected from the group consisting of primary amines, secondary amines and tertiary amines, and (3) converting the reaction products into the salt form or into polymeric quaternary ammonium salts. The use of these polymeric amine salts or quaternary ammonium salts in cosmetic hair-treatment preparations provides these preparations with antistatic effects.Type: GrantFiled: July 8, 1986Date of Patent: February 13, 1990Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Wolfgang Ritter, Rolf Tenhaef, Horst Hoffkes, Kurt Seidel
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Patent number: 4900543Abstract: An aqueous hair-treatment preparation containing an antistatic additive imparting an antistatic effect to the hair, characterized in that said antistatic additive is at least one cationic polymer produced by the process of (1) epoxidizing 1,3-diene homopolymers or copolymers, (2) amine reacting the epoxide compound so produced with low molecular weight amines selected from the group consisting of primary amines, secondary amines and tertiary amines, and (3) converting the reaction products into the salt form or into polymeric quaternary ammonium salts. The use of these polymeric amine salts or quaternary ammonium salts in cosmetic hair-treatment preparations provides these preparations with antistatic effects.Type: GrantFiled: July 17, 1986Date of Patent: February 13, 1990Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Wolfgang Ritter, Rolf Tenhaef, Horst Hoffkes, Kurt Seidel
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Patent number: 4898883Abstract: The present invention relates to 1-substituted derivatives of 4-methoxy-2,3,6-trimethylbenzene which are useful in cosmetic or pharmaceutical preparations for use in the treamtnet of dermatological complaints connected with a keratinisation disorder, dermatological complaints having an inflammatory and/or immuno-alleric component or ophthalmological complaints.Type: GrantFiled: July 21, 1987Date of Patent: February 6, 1990Assignee: L'OrealInventors: Gerard Lang, Serge Forestier, Alain Lagrange, Braham Shroot
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Patent number: 4897269Abstract: A method for administering a slightly water soluble biologically active compound by topically applying a pharmaceutical composition containing:(a) lipid vesicles with a biologically active compound captured therein;(b) a saturated solution of the biologically active compound; and(c) the biologically active compound in solid form.Optionally this composition is dispersed in a hydrocolloid gel.Type: GrantFiled: June 27, 1988Date of Patent: January 30, 1990Assignee: Mezei Associates LimitedInventor: Michael Mezei
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Patent number: 4892940Abstract: An aromatic naphthyl compound of the formula ##STR1## wherein n is 0 or 1,R' is hydrogen, OH, acyloxy, alkoxy or NH.sub.2,R" is hydrogen or lower alkoxy, or R' and R" taken together form an oxo, methano or hydroxy-imino radical,R is --CH.sub.2 OH or --COR.sub.8,R.sub.8 is hydrogen, --OR.sub.9 or ##STR2## R.sub.9 is hydrogen, alkyl having 1-20 carbon atoms, mono or polyhydroxyalkyl, aryl, aralkyl, the residue of a sugar or ##STR3##is 1, 2 or 3,r' and r" each independently represent hydrogen, alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl, benzyl, the residue of amino acid or the residue of aminated sugar, or r' and r" together form a heterocycle,R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent hydrogen, lower alkyl, alkoxy having 1-4 carbon atoms, fluoroalkoxy, CF.sub.3, cycloalkyl, lower acyl, halogen, OH, amino, acylamino or alkoxy carbonyl,R.sub.5, R.sub.6 and R.sub.7 represent hydrogen or methyl or when n=1, R.sub.5 and R.sub.Type: GrantFiled: May 22, 1987Date of Patent: January 9, 1990Assignee: L'OrealInventors: Jean Maignan, Gerard Lang, Gerard Malle, Serge Restle, Braham Shroot
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Patent number: 4889843Abstract: The salt formed between the polyanions forming the Trichosaccharide and the NH.sub.2 groups of 2,4-diamino-6-piperidino-pyrimidine-3-oxide represents a novel trichogenic factor by which the activity of the single components is enhanced and the seriously toxic side effects of Minoxidil are done away with.Type: GrantFiled: January 17, 1989Date of Patent: December 26, 1989Assignee: Crinos Industria Farmacobiologica Spa.Inventor: Giovanni Gazzani
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Patent number: 4886660Abstract: A stable shine hair conditioner formulation which provides shiny, smooth, manageable hair, easy to comb, easy to style, long holding power and is cost effective consisting essentially of effective amounts of C.sub.14 -C.sub.22 alkyl trimethyl quaternary ammonium compound, mineral oil or glyceryl monostearate, a C.sub.14 -C.sub.22 alkanol, a cellulose polymer, a copolymer of polyvinylpyrrolidone and vinyl acetate (PVP/VA) and a plasticizer selected from the group consisting of lanolin acetate, propylene glycol, glycerine, and water soluble lanolin, in an aqueous vehicle.Type: GrantFiled: June 11, 1987Date of Patent: December 12, 1989Assignee: Colgate-Palmolive CompanyInventors: Amrit Patel, Frank Schebece, Harry Greenland
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Patent number: 4874791Abstract: A hair-growing agent which exhibits a strong hair-growing effect. The hair-growing agent according to the present invention contains as an effective ingredient an aliphatic carboxylic acid having an odd number of carbon atoms or a derivative thereof.Type: GrantFiled: October 28, 1986Date of Patent: October 17, 1989Assignee: Lion CorporationInventors: Kuniaki Adachi, Hideo Tamai, Masanao Sadai
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Patent number: 4874747Abstract: A polycyclic heterocyclic compound has the formula ##STR1## wherein n is 1 or 2,R.sub.1 l represents (i) lower alkyl, (ii) --CH.sub.2 OH or (iii) ##STR2## R.sub.2 represents (a) hydrogen, (b) ##STR3## or (c)--OR.sub.3, R.sub.3 represents hydrogen, C.sub.1 -C.sub.20 alkyl mono or polyhydroxyalkyl, aryl or aralkyl optionally substituted, the residue of a sugar or ##STR4## wherein p is 1, 2, or 3, and r' and r" represent hydrogen, lower alkyl, mono or polyhydroxyalkyl, aryl optionally substituted, amino acid residue, aminated sugar residue, or together form a heterocycle,X represents oxygen, sulfur, SO, SO.sub.2 or --NR.sub.4,Y represents CR.sub.4 or a nitrogen atom andR.sub.4 represents hydrogen or lower alkyl.This polycyclic heterocyclic compound can be used in human and veterinary medicine and especially in the topical or systemic treatment of determatologic diseases.Type: GrantFiled: April 29, 1988Date of Patent: October 17, 1989Assignee: Centre International de Recherches Dermatologiques (CIRD)Inventors: Braham Shroot, Jacques Eustache, Jean-Michel Bernardon, Philippe Nedoncelle
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Patent number: 4871839Abstract: A composition suitable for topical application to human skin, particularly the scalp comprises a minoxidil glucuronide together with a cosmetically and/or physiologically acceptable vehicle. The composition is particularly suited to stimulating hair growth or regrowth.Type: GrantFiled: March 5, 1987Date of Patent: October 3, 1989Assignee: Lever Brothers CompanyInventor: Walter T. Gibson
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Patent number: 4870010Abstract: Personal care products comprising bioemulsifiers, for example, those produced by Acinetobacter calcoaceticus, are provided. Use of such personal care products result in beneficial effects to skin and hair.Type: GrantFiled: April 15, 1986Date of Patent: September 26, 1989Assignee: Petroleum Fermentations N.V.Inventor: Michael E. Hayes
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Patent number: 4863898Abstract: Amino acid chelates having a ligand to divalent metal mole ratio of at least 2:1 and having a molecular weight of not more than 1500 and preferably not more than 1000 and also having a stability constant of between about 10 and 10 are formulated for delivery to one or more specific tissue sites within a mammal. The ligand utilized in formulating the amino acid chelate is a naturally occuring amino acid or a dipeptide, tripeptide or quadrapeptide thereof. The selection of an appropriate ligand with which to form the chelate provides a product that, when entering the bloodstream of the mammal, either by mean of oral ingestion or injection, has a propensity to migrate to one or more targeted tissue sites within the mammal.Type: GrantFiled: February 6, 1986Date of Patent: September 5, 1989Assignee: Albion International, Inc.Inventors: Harvey H. Ashmead, H. Dewayne Ashmead, Darrell J. Graff
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Patent number: 4861593Abstract: A creamy water-in-oil conditioner-dressing for hair comprising: wheat germ oil, Brewers yeast flakes, the oils of vitamins A, D and E, propylene glycol, glycerol, jojoba oil, methyl and propyl parabens, deionized water, petrolatum, Sodium Lauryl Sulfate, n-stearyl alcohol, n-cetyl alcohol and fragrance.Type: GrantFiled: October 29, 1987Date of Patent: August 29, 1989Inventors: JoAnn M. Spearmon, Sharon I. Jackson
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Patent number: 4855131Abstract: The present invention relates to a preparation for the treatment of skin or scalp affections, with an exclusively plant basis, obtained by infusion in vinegar of Geum, Lavandula, Mentha, Allium, and Salvia, preferably with the addition of other plant substances having a calmative or aroma-giving action; the preparation has shown itself to be outstandingly efficacious in impeding certain conditions which promote loss of hair.Type: GrantFiled: June 8, 1988Date of Patent: August 8, 1989Assignee: IRIS S.a.s. di Salvioli Michele e C.Inventor: Pasini Iris
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Patent number: RE33533Abstract: A polycyclic heterocyclic compound has the formula ##STR1## wherein n is 1 or 2, R.sub.1 represents (i) lower alkyl, (ii)--CH.sub.2 OH or (iii) ##STR2## R.sub.2 represents (a) hydrogen, (b) ##STR3## or (c)--OR.sub.3, R.sub.3 represents hydrogen, C.sub.1 -C.sub.20 alkyl mono or polyhydroxyalkyl, aryl or aralkyl optionally substituted, the residue of a sugar or wherein p is 1, 2, or 3, and r' and r" represent hydrogen, lower alkyl, mono or polyhydroxalkyl, aryl optionally substituted, amino acid residue, aminated sugar residue, or together form a heterocycle, X represents oxygen, sulfur, SO, SO.sub.2 or --NR.sub.4, Y represents CR.sub.4 or a nitrogen atom and R.sub.4 represents hydrogen or lower alkyl. This polycyclic heterocyclic compound can be used in human and veterinary medicine and especially in the topical or systemic treatment of determatologic diseases.Type: GrantFiled: April 24, 1990Date of Patent: February 5, 1991Assignee: Centre International de Recherches Dermatologiques (CIRD)Inventors: Braham Shroot, Jacques Eustache, Jean-Michel Bernardon, Philippe Nedoncelle