Abstract: A method of inhibiting hirsutism or alopecia in women comprising administering to a female human in need of treatment an effective amount of a compound having the formula ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, --CH.sub.3, ##STR2## wherein Ar is optionally substituted phenyl; R.sup.2 is selected from the group consisting of pyrrolidine, hexamethyleneamino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.

Abstract: Combination of pyrimidine derivatives and retinoids, as separate components, for inducing and stimulating hair growth and reducing its loss.Combination designed to induce and stimulate hair growth and reduce its loss, characterized in that it comprises in separated form:a) a component (A) containing at least one retinoid in a physiologically acceptable medium, andb) a component (B) containing at least one pyrimidine derivative in a physiologically acceptable medium.

Abstract: A composition for inducing and stimulating hair growth and/or reducing hair loss comprises at least one alkylpolyglycoside and at least one compound having formula (I) in a physiologically acceptable medium. ##STR1## In compound (I) , R.sub.1 represents the group ##STR2## where in R.sub.3 and R.sub.4 may be selected from hydrogen, alkyl, alkenyl or cycloalkyl. R.sub.3 and R.sub.4 may also form a heterocycle with the nitrogen atom to which they are bonded. The heterocycle may be an aziridinyl, azetidinyl, pyrrolidinyl, piperidinyl, hexahydroazepinyl, heptamethyleneimine, octamethyleneimine, morpholine or 4-low alkylpiperazidinyl group. These heterocycles may be substituted at the carbon atoms by one to three alkyl, hydroxy or alkoxy groups. R.sub.2 is selected from hydrogen, alkyl, alkenyl, alkylalkoxy, cycloalkyl, aryl, alkylaryl, arylalkyl, alkylarylalkyl, alkoxyarylalkyl and/or haloarylalkyl. The physiologically acceptable acid addition salts of the compound may also be used.

Abstract: The subject invention involves a method for treating hyperproliferative conditions in mammalian epithelial cells comprising administering to the mammal a composition containing a safe and effective amount of a lysophosphatidic acid compound or derivative having the structure ##STR1## or a cyclic derivative thereof having the structure ##STR2## or a pharmaceutically acceptable salt thereof, wherein: a) --Y-- is --0-- or --CH.sub.2 --;b) --Z is --XH, --H or halo;c) each --X-- is independently --0-- or --S--; andd) --R is unsubstituted or substituted, saturated or unsaturated, straight or branched chain alkyl having from 11 to about 23 carbon atoms.

Abstract: A scalp-moisturizer or external skin preparation containing as essential active ingredients the following: (a) steroid glycoside and/or triterpenoid glycoside, (b) sphingo glycolipid and (c) steroid hormone, the content of (a) and (b) being 0.01-10% by weight of the total, the (a)/(b) ratio by weight being 85/15-30/70 and (c) being incorporated in effective amounts of not more than 0.1% by weight of the total.

Abstract: Storage-stable, pseudoplastic free-flowing cosmetic compositions/formulations, for example shampoos, shower and exfoliating gels and hair lotions, comprise a stable and homogeneous suspension, in water, of water-insoluble particulates, and which further comprise at least one anionic surfactant, at least one nonionic or amphoteric cosurfactant and at least one electrolyte, these surfactants being present in such amounts as to impart pseudoplasticity thereto with a yield point of at least 0.2 Pa and constituting spherulites suspended within a lamellar phase.

Abstract: Methods are provided for preparing compositions suitable for protecting irritated or damaged skin from further oxidative and biochemical damage and thus permitting natural healing processes to progress, for accelerating the rate of healing of burns and surgical wounds, and for increasing the size of hair follicles and the rate of hair growth. The compositions generally comprise precipitates formed by the complexation of peptone digests of various proteins with copper(II) salts, indium (III) salts, tin(II) salts and tin(IV) salts.

Abstract: A method for removing nits (e.g., lice eggs) from hair which comprises the application of a water-based enzyme composition to the hair, whereby the water-based enzyme composition is capable of causing swelling and/or biodegrading of the complex organic structure that cements nits to the hair to facilitate the subsequent physical removal of the nits from the hair.

Abstract: The instant invention involves a method of treating and/or reversing androgenic alopecia and promoting hair growth, and methods of treating acne vulgaris, seborrhea, and female hirsutism, by administering to a patient in need of such treatment a 5.alpha.-reductase 2 inhibitor, such as finasteride, in a dosage amount under 5 mgs/day.

Abstract: The present invention relates to novel carbazole derivatives corresponding to the formula: ##STR1## in which R.sub.1 is H, benzyl or alkyl; R.sub.2 and R.sub.3 are a carbethoxy, acetyl, nitrile, ##STR2## with R.sub.2 =R.sub.3 other than H, or R.sub.2 and R.sub.3 form the following ring systems: ##STR3## R.sub.4 is H, Cl, methoxy, nitrile or nitro; R.sub.5, R.sub.7 and R.sub.8 are H or methoxy; R.sub.6 is H or methyl; with the proviso that if R.sub.2 and R.sub.3 form the ring system (c), at least one of R.sub.1, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 does not denote H.The invention also relates to the use in cosmetics of these novel compounds as pigments, and in particular in cosmetic compositions intended for the treatment and/or the coloration of keratinous substances.

Abstract: An anti-seborrhoeic composition containing both a broad spectrum antifungal drug and a topical antiseptic is disclosed for the treatment of dogs. The composition can be formulated as a shampoo further containing a keratolytic or keratoplastic compound. The preferred antifungal drug is miconazole and the preferred topical antiseptic is chlorhexidine, and the formulation optionally contains selenium sulphide as an added ingredient.

Abstract: A skin-conditioning composition is disclosed which can be applied topically to improve skin cell renewal rates with low irritation levels and comprises minor proportions of a salicylic acid and a somewhat hydrophobic alpha hydroxy aliphatic acid formulated into an acidic cosmetic composition, optionally with an anti-irritant or anti-oxidant additive. Preferred acids are salicylic and lactic and appropriate compositions are also useful topical treatments for the scalp to reduce hair loss.

Abstract: The invention relates to sustained-release biodegradable lice repelling preparations comprising as active ingredient a lice repelling agent comprising at least one natural oil selected from the group consisting of citronella oil, rosemary oil and eucalyptus oil, or at least one natural oil component selected from the group consisting of citronellal and geraniol or mixtures thereof and further comprising an anionic emulsifier and chitosan, optionally further comprising dermatologically acceptable additives, carriers or diluents. The preparations may be in the form of an aqueous emulsion or chitosan microcapsules, preferably prepared by the processes of the invention.

Abstract: Increase in the rate of hair growth, stimulation of hair follicles to produce new hair growth, prolongation of the anagen phase of the hair cycle, and conversion of vellus hair to growth as terminal hair, and treatment of alopecias due to organic dysfunction of the hair follicle is attained in mammalian skins by either oral administration or by topical application to the skin, hair and/or hair follicles of the mammal of effective amounts of a retinoid, particularly retinoic acid. The retinoid may be administered or applied alone or with other adjunctive compounds including vitamins, such as Vitamin D.sub.3, hormones, antiandrogens and/or vasodilators.

Abstract: A formulation and method of treatment for androgenic alopecia wherein the active ingredient is liquor carbonis detergens, in combination with spirits of camphor, castor oil, isopropyl alcohol, and optionally salicyclic acid.

Abstract: The present invention relates to a novel composition based on hydrated lipidic lamelar phases or on liposomes and to a cosmetic or pharmaceutical, particularly dermatological composition incorporating it. The hydrated lipidic lamelar phases or the liposomes contain at least in part a derivative of labdane, or a plant extract containing it. The invention reduces hair drop and promotes regrowth of hair and also prevents gray hair from appearing and provides a treatment for gray hair.

Abstract: A dermatological pharmaceutical composition for stimulating hair growth and for the treatment of conditions of the skin selected from the group consisting of(a) benign moles, papillomas and seborrheic keratoses;(b) unsightly freckles, pimples and blemishes;(c) stasis dermatitis;(d) dermal ulcers; and(e) fungal nail infections; and(f) gingival and mucous membrane inflammations;the composition comprising an effective amount of tannic acid, a debriding agent and a pharmaceutically acceptable carrier therefore.

Abstract: A method of treating dandruff in warm-blooded animals comprising applying to the hair of a warm-blooded animal an anti-dandruff effective amount of an alkali metal or ammonium salt of a low molecular weight huminate with a mean molecular weight of 1000 with a range of 300 to 1500 and a method of treating or preventing dandruff.

Abstract: The invention relates to cosmetic preparations which have a content of compounds of the general formula I ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 are identical or different and are hydrogen or alkyl with 1 to 4 carbon atoms, where R.sup.1 and R.sup.3 are preferably hydrogen and R.sup.2 is preferably methyl,X is S or O,Y is hydrogen or up to two halogen atoms, preferably chlorine and/or bromine,Z is a single bond or the divalent radicals 0, S, --CH.sub.2 --, --CH.sub.2 --O--, --O--CH.sub.2 --, --CH.sub.2 --S--, --S--CH.sub.2 -- or --CH.dbd.CH--CH.sub.2 --O--,Ar is an aromatic ring system which has up to two rings and which can be substituted by up to three radicals from the group comprising fluorine, chlorine, bromine, methoxy, C.sub.1 -C.sub.4 -alkyl, trifluoromethyl and trifluoromethoxy,and/or their salts.The invention furthermore relates to the use of these cosmetic preparations as antidandruff composition and deodorant cosmetic composition.

Abstract: The present invention relates, in general, to a method of inhibiting alopecia, or hair loss, and, in particular, to a method of inhibiting alopecia induced by chemotherapeutic agents. The invention further relates to a composition suitable for use in such a method. Active agents for use in the above method include proteinaceous growth factors, such as EGF, and/or vitamin D.sub.3 or metabolites thereof.

Abstract: An external skin treatment composition containing (I) vitamin A (retinol) and (II) as a stabilizer, a chelating agent/a polysaccharide, an oil, polyethylene (propylene) glycol, a hydroxy carboxylate, a neutral amino acid salt, an oil-soluble antioxidant/EDTA/a benzophenone compound, an oil-soluble antioxidant/an acid/a benzophenone compound, an inclusion compound of cyclodextrin including an antioxidant and/or an ultraviolet absorber, butanediol and/or an oil-soluble antioxidant, a water-soluble benzophenone compound, a basic amino acid and the salt thereof, an acidic amino acid and the salt thereof, a polar oil, a water-swellable clay mineral.

Abstract: The present invention provides compositions and methods for promoting hair growth. The methods generally comprise the administration to a patient of a therapeutically effective amount of the compositions of the present invention which employ a vasodilator in combination with estradiol and/or a 5-.alpha.-reductase inhibitor in a pharmaceutically acceptable vehicle. The compositions and methods of the present invention are suitable for the treatment of baldness, in particular, male pattern baldness.

Abstract: Mammalian hair growth is reduced by applying to the skin a composition including an inhibitor of ornithine aminotransferase.

Abstract: Mammalian hair growth is reduced by applying to the skin an inhibitor of nitric oxide synthetase.

Abstract: Composition for slowing down hair loss and inducing and stimulating its growth, comprising a compound of the following formula: ##STR1## wherein R.sub.1 and R.sub.3 denote H; R.sub.2 and R.sub.4 denote H or an alkyl; R.sub.5 denotes H, an alkyl, an alkenyl, a cycloalkyl, an aryl, an arylalkyl, a hydroxyalkyl or an aminoalkyl; X denotes H, halogen, alkyl, nitro, benzoyloxy or --NHR.sub.6 where R.sub.6 denotes H, acyl or alkyl; Z denotes sulfur or oxygen, with the proviso that Z denotes sulfur when X denotes H or R.sub.5 denotes aryl; Y denotes oxygen or OSO.sub.3 ; as well as its physiologically acceptable salts.

Abstract: A hair treatment composition comprising from 0.00001 to 0.01% by weight of a perfluoropolyether material.

Abstract: Method for diagnosing a cellular aging or inflammation condition of keratinocytes of the skin or a pilous follicle in a person, or for diagnosing the efficiency of a treatment intended to combat said condition. To this effect, the concentration or activity of certain markers (catalase, glutathion or glutathion peroxydase) is compared in the keratinocytes suspected of being pathological and the keratinocytes of a reference non pathological area. The pathological condition intensifies the activity of the catalase, or reduces the activity of other markers. Application particularly to the diagnosis of alopecia, and to the estimation of the efficiency of a treatment of baldness with minoxidil in a given individual.

Abstract: The combination comprises:a) a component (A) containing a pyrimidine derivative of formula: ##STR1## in which R.sub.1 denotes ##STR2## in which R.sub.3 and R.sub.4 denote hydrogen, alkyl, alkenyl, alkylaryl or cycloalkyl, R.sub.3 and R.sub.4 may also form a heterocyclic ring with the nitrogen atom to which they are linked, R.sub.2 is hydrogen, alkyl, alkenyl, alkoxyalkyl, cycloalkyl, aryl, alkylaryl, arylalkyl, alkylarylalkyl, alkoxyarylalkyl or haloarylalkyl; andb) a component (B) containing a salicylic acid derivative.The components (A) and (B) forming part of the same single composition or being intended to be employed separately, either simultaneously or successively or at intervals of time, on the hair and the scalp.

Abstract: Methods and compositions containing cAMP salts in combination with inert carriers for preventing or restoring grayed hair to its natural color.

Abstract: A topical agent and method for the treatment and prevention of pseudofolliculitis barbae, related secondary bacterial infections and other skin conditions associated with shaving result from a combination of three ingredients, namely benzoyl peroxide, camphor oil and aloe vera present in 15:4:1 parts by volume of the composition, respectively.

Abstract: Aloe water containing no aloesin is obtained by forming a pulp from aloe leaves, boiling the pulp at a reduced pressure to obtain vapors, condensing the vapors, and collecting the vapors. The pulp is optionally fermented before boiling. The aloe water can be used for treating skin and hair.

Abstract: Cosmetic compositions are described wherein .alpha.-hydroxyacids, .alpha.-ketoacids and related compounds are formed into amine salts through neutralization with a multi-amine functionalized polymer. Particularly preferred are glycolic acid and lactic acid salts of poly(ethylenimine).

Abstract: Methods and products for promoting hair growth, preventing or minimizing hair loss, enhancing or restoring hair color or remelanization and treating other hair and skin afflictions are disclosed. The methods includes topical application of the products to the skin or hair follicles being treated. The product includes as an essential component a treatment agent in an amount effective for treating the affliction and selected from the class of chemicals consisting of anol, anethole, analogs of the above, polymers of the above and mixtures thereof. Various combinations of these chemicals may be found in herb families including umbelliferae, magnoliaceae, labiatae and rutaceae. The invention preferably contemplates selecting the treatment agent from the class of herbs consisting of Foeniculum vulgares (fennel seed), Pimpinella anisum (anise), Carum carvi (caraway seeds) and mixtures of the above herbs with each other and/or with other herbs.

Abstract: A dermatological pharmaceutical composition for stimulating hair growth and for the treatment of conditions of the skin selected from the group consisting of(a) benign moles, papillomas and seborrheic keratoses;(b) unsightly freckles, pimples and blemishes;(c) stasis dermatitis;(d) dermal ulcers; and(e) fungal nail infections; and(f) gingival and mucous membrane inflammations;the composition comprising an effective amount of tannic acid, a debriding agent and a pharmaceutically acceptable carrier therefore.

Abstract: Oil-in-water emulsions can be formed using surfactants with biospecific headgroups. Emulsion droplets adhere to surfaces of microorganisms or to various biological surface bearing appropriate adhesins, thus delivering surfactant materials directly to various surfaces. Lipophilic materials and essential oils can be targeted in this way. The emulsions may be incorporated into oral hygiene non-food compositions or compositions for topical application to skin, hair or nails.

Abstract: The present invention provides compositions and methods for promoting hair growth. The methods generally comprise the administration to a patient of a therapeutically effective amount of the compositions of the present invention which employ a vasodilator in combination with estradiol and/or a 5-.alpha.-reductase inhibitor in a pharmaceutically acceptable vehicle. The compositions and methods of the present invention are suitable for the treatment of baldness, in particular, male pattern baldness.

Abstract: A hair shampoo composition comprising a cleansing surfactant; a water-insoluble hair treating compound, like a hair conditioner or an antidandruff agent; a suspending agent comprising an amine including at least one long carbon chain and a suitable acid; and a suitable carrier, and a method of treating hair are disclosed. The shampoo compositions effectively suspend the water-insoluble hair-treating compound, effectively cleanse the hair and effectively deliver the water-insoluble hair-treating compound to the hair or scalp.

Abstract: An opacifier comprising an amine including at least one carbon chain of at least 16 carbon atoms or a fatty amidoamine having an alkyl group including at least about thirteen carbon atoms, and a suitable acid is disclosed. The opacifier is a salt of the long-chain amine and effectively opacifies, or pearlizes, water-based compositions, such as hair treating compositions, like shampoos, conditioners, conditioning shampoos and antidandruff shampoos; and skin treating compositions, like conditioners, moisturizers and topical medicaments.

Abstract: Methods and compositions for restoring grayed hair to its natural color comprising at least one compound of the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 may be the same or different and each represents a hydrogen atom, an acyl group having 5 to 15 carbon atoms derived from a monocarboxylic acid having 5 to 15 carbon atoms or an acyl group having 2 to 15 carbon atoms derived from a dicarboxylic acid having 2 to 15 carbon atoms or an alkyl group having 1 to 2 carbon atoms; X.sub.1 and X.sub.2, respectively, represent a hydrogen atom, a halogen, or a mercapto group; with the proviso that when R.sub.1, R.sub.2 and R.sub.3 and X.sub.1 are hydrogen atoms at the same time, X.sub.2 is not a halogen atom or a mercapto group, and M.sub.1 represents a hydrogen atom, an alkali metal or tris(hydroxymethyl)aminomethane.

Abstract: A series of dihydrophenanthreneones and tetrahydrophenanthreneones are useful as inhibitors of 5.alpha.-reductase, and a series of hexahydrophenanthreneones are useful as intermediates for preparing such pharmaceuticals.

Abstract: Liquid fiber-treating and skin-treating compositions include surfactant, water insoluble treating material, water and long chain alcohol or derivative thereof, which stabilizes the liquid so as to allow storage at elevated temperatures, such as those which can be reached during storage in warmer climates, and which also helps to make fiber- and skin-treating materials more substantive to fibers and skin. Among the various types of compositions benefited are shampoos, perfuming shampoos, hair conditioning compositions, hair setting compositions, anti-dandruff preparations, fabric softening compositions, antistatic compositions, detergents, skin cleansers, skin lotions and sunscreens.

Abstract: A composition for preventing graying of the hair and restoring grayed hair to its natural color comprises an effective amount of one member selected from the group consisting of cAMP compounds such as 8-butylthio cAMP-Na or 8-methoxy cAMP-Na and water. The composition can prevent graying of the hair and restoring grayed hair to its natural color upon application to the scalp, the effective component is very stable even in the form of compositions containing water and the composition does not cause quality deteriorations such as giving out of bad smell.

Abstract: A composition for topical application to mammalian skin or hair is provided which comprises:i) an effective amount of from 0.5 to 50% by weight of a glycosaminoglycanase inhibitor chosen from specific monosaccharide derivativesii) from 0.5 to 50% by weight of ethane diol; andiii) up to 99% by weight of a cosmetically acceptable vehicle for the glycosaminoglycanase inhibitor.

Abstract: The present invention relates to minoxidil aceturate corresponding to the formula I ##STR1## The invention also encompasses the process for preparing minoxidil aceturate, as well as its use as an active principle in dermato-cosmetic compositions, especially in hair-care compositions intended for the treatment of alopecia.

Abstract: An anhydrous, topically-effective composition that resists phase separation and exhibits improved properties comprising a topically-active compound, such as an astringent salt; an improved suspending agent comprising a finely-divided silica and a suspending wax composition; and a suitable volatile liquid carrier, such as a volatile silicone or a volatile hydrocarbon. The suspending wax composition comprises a wax, an ester including at least 10 to about 32 carbon atoms and a volatile liquid carrier. The anhydrous, topically-effective composition is useful in topical cosmetic and medicinal preparations, such as antiperspirants, sunscreens and topical drug products, and is especially useful in cosmetic and medicinal preparations wherein an insoluble topically-active compound is dispersed throughout a liquid phase.

Abstract: Compositions, for example cosmetic or pharmaceutical compositions, and methods of increasing melanin formation on the skin or scalp employ liposomes including between 0.001 and 10 weight percent, with respect to the total weight of the composition, of tyrosine or a tyrosine derivative selected from the group consisting of an alkali metal salt of L-tyrosine, an alkaline earth metal salt of L-tyrosine, methyl L-tyrosinate, ethyl L-tyrosinate, and stearyl L-tyrosinate.

Abstract: A vasodilating agent and a hair growth promoting agent comprising an extract of hypericum erectum thunb as an effective component are disclosed. The hypericum erectum thunb extract is prepared from ground leaf, stem, root, fruit, seed, or flower of hypericum erectum thunb by extraction with an organic solvent. It is effective for curing or preventing diseases caused by disorder in blood circulation such as hypertension, angina pectories, myocardial infarction, congestive heart failure, frostbite, chilblain, cold constitution, and alopecia.

Abstract: Hydroxy-substituted [(D)Ser].sup.8 -Ciclosporin derivatives, particularly [O-(2-hydroxyethyl)(D)Ser].sup.8 -Ciclosporin, have advantageous pharmacological properties and are useful as immunosuppressants, for example in the treatment of transplant rejection and autoimmune diseases.

Abstract: A benzonaphthalene compound has the formula ##STR1## wherein R.sub.1 represents ##STR2## or (ii) --CH.sub.2 OH; R.sub.6 represents ##STR3## or OR.sub.7 wherein R.sub.7 represents hydrogen, alkyl having 1-20 carbon atoms, monohydroxyalkyl or polyhydroxyalkyl, r' or r" represent hydrogen, lower alkyl, mono or polyhydroxyalkyl, aryl or a residue of an amino acid or a sugar, or together form a heterocycle; R.sub.2 represents hydrogen, alkyl having 1-15 carbon atoms, alkoxy having 1-4 carbon atoms or a cycloaliphatic radical; R.sub.3 represents hydrogen, hydroxy, alkyl having 1-4 carbon atoms, alkoxy having 1-10 carbon atoms, a cycloaliphatic radical, a thiocycloaliphatic radical or --O--Si(CH.sub.3).sub.2 --R.sub.8 wherein R.sub.8 represents lower alkyl; and R.sub.4 and R.sub.5 represent hydrogen, lower alkyl, hydroxy or lower acyloxy.This compound is useful in the topical and systemic treatment of dermatologic diseases and in the treatment of the degeneration of conjunctive tissues.

Abstract: The subject invention relates to methods for promoting hair growth in mammals comprising topical application of dyphylline or a pharmaceutically-acceptable salt thereof. The subject invention further involves topical compositions comprising dyphylline.