Oil-water Type Patents (Class 514/938)
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Patent number: 7754776Abstract: Highly concentrated oil-in-water aqueous emulsions of nitrogen-containing organopolysiloxanes are prepared by dispersing the organopolysiloxanes in water without substantial addition of acid, to form a flowable, dilutable, storage stable emulsion containing 45 weight percent or more organopolysiloxane and a pH of at least 7.5.Type: GrantFiled: November 6, 2003Date of Patent: July 13, 2010Assignee: Wacker Chemie AGInventors: Otto Schneider, Thomas Hohberg
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Patent number: 7696252Abstract: Methods for the formation of colloidal suspensions. The method includes combining an aqueous substance with a second substance that is normally immiscible with the aqueous substance, to form a mixture, and before, during or after the combining removing dissolved gases from one or both of the aqueous and second substance, whereby the aqueous and second substances mix and form a colloidal suspension. The methods for the formation of colloidal suspensions include methods for the formation of emulsions as well as particulate dispersions. The methods used to form the colloidal suspensions in accordance with the present invention produce colloidal suspensions that are stable for periods from an hour to several weeks in the absence of surfactants or stabilizing agents.Type: GrantFiled: November 5, 2003Date of Patent: April 13, 2010Assignee: Australian National UniversityInventor: Richard M Pashley
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Patent number: 7622510Abstract: A method and a device for making a dispersion or an emulsion (41) from at least two fluids known to be unmiscible, the fluids constituting a dispersed phase (40) and a dispersing phase (44), the dispersed phase (40) being driven through a porous body (24) into the dispersing phase (44). The invention is characterized in that the porous body (24) is vibrated by a mechanical, electrical or magnetic excitation.Type: GrantFiled: October 15, 2003Date of Patent: November 24, 2009Inventor: Christophe Arnaud
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Patent number: 7517534Abstract: A process for the preparation of an o/w emulsion, which comprises mixing together a high molecular compound carrying at least on side chains thereof groups represented by the following formula (1): —(OX)n-E2-R??(1) wherein n “X”s may be the same or different and each independently represents a linear or branched, divalent, saturated C1-6 hydrocarbon group, n stands for a number of from 5 to 300, E2 represents an ether bond or an oxycarbonyl group (—OCO— or —COO—), and R represents a linear or branched, C4-30 alkyl group which may be substituted by hydroxyl group(s), an aqueous solution of a water-soluble polyol, and a hydrophobic compound, and diluting a resulting mixture with water, and the o/w emulsion obtained by the preparation process. The emulsion according to the present invention is excellent in touch feeling to the skin and is good in stability.Type: GrantFiled: March 12, 2002Date of Patent: April 14, 2009Assignee: Kao CorporationInventors: Takahiro Nishizaka, Takeshi Ihara, Tomohito Kitsuki
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Patent number: 7452917Abstract: Oil-in-water emulsions comprised of: (a) a polyol poly-12-hydroxystearate polyester; (b) an alkyl polyglycoside; (c) an oil; and (d) from 5 to 30% by weight water. When used as paper additives, the emulsions significantly improve the softness and feel of the paper products.Type: GrantFiled: January 10, 2002Date of Patent: November 18, 2008Assignee: Cognis Deutschland GmbH & Co. KGInventors: Guido Baumoeller, Rolf Kawa, Roland Spoerer, Stephan Eichhorn
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Patent number: 7452864Abstract: Use of the antimicrobial cathelicidin peptide ll-37, N-terminal fragments of LL-37 or extended sequences of LL-37 having 1-3 amino acids in the C-terminal end, for stimulating proliferation of epithalial and stromal cells and thereby healing of wounds, such as chronic ulcers. The cytotoxic effect of LL-37 may be reduced by including a bilayer-forming polar lipid, especially a digalactosyldiacylglycerol, in pharmaceutical compositions and growth media comprising LL-37.Type: GrantFiled: January 28, 2004Date of Patent: November 18, 2008Assignee: Lipopeptide ABInventors: Mona Ståhle-Bäckdahl, Johan Heilborn, Anders Carlsson, Conny Bogentoft
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Patent number: 7445729Abstract: Organic peroxide compositions are stabilized against decomposition by the use of antioxidants, resulting in increased shelf life of products made using the compositions.Type: GrantFiled: November 21, 2007Date of Patent: November 4, 2008Assignee: JR Chem, LLCInventors: Joseph R. Faryniarz, Jose E. Ramirez
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Patent number: 7431937Abstract: Compositions, optionally heat-activated, methods and kits for protecting keratinous fibers from extrinsic damage or repairing keratinous fibers damaged by extrinsic conditions by applying to keratinous fibers a composition comprising at least one compound comprising at least one C5 to C7 saccharide unit substituted with at least one amino group and derivatives thereof, and heating the keratinous fibers.Type: GrantFiled: March 30, 2001Date of Patent: October 7, 2008Assignee: L'Oreal, S.A.Inventors: David W. Cannell, Natalya Fadeeva, Nghi Van Nguyen
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Patent number: 7416719Abstract: The present invention is a sunscreen composition that has at least one sunscreen agent and at least one glucoside emulsifier. The composition also has water. Preferably, the sunscreen composition also has at least one of the following additional components: an emulsifier other than glucoside, emollient, skin-feel additive, moisturizing agent, film former/waterproofing agent, pH adjuster/chelating agent, preservative, or any combinations thereof. The composition is a stable oil-in-water emulsion.Type: GrantFiled: April 30, 2004Date of Patent: August 26, 2008Assignee: Playtex Products, Inc.Inventors: Jose L. Huerta, James Sanogueira, Jennifer Fuller
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Patent number: 7390431Abstract: Organic peroxide compositions are stabilized against decomposition by the use of antioxidants, resulting in increased shelf life of products made using the compositions.Type: GrantFiled: March 10, 2006Date of Patent: June 24, 2008Assignee: JR Chem, LLCInventors: Joseph R. Faryniarz, Jose E. Ramirez
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Patent number: 7387790Abstract: Nanoparticles made from a select group of lipids and optionally containing a therapeutically active agent are employed in pharmaceutical compositions for delivery to targeted tissues and/or cells for the treatment or diagnosis of such diseases as cancer.Type: GrantFiled: June 14, 2002Date of Patent: June 17, 2008Assignee: Cornerstone PharmaceuticalsInventors: Robert Shorr, Robert Rodriguez
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Patent number: 7387795Abstract: The invention provides cosmetic compositions containing powders that are surface treated with organophosphonic acid compounds, where the surface treated particulates are simultaneously hydrophobic and lipophilic. The invention also provides (a) methods for preparing cosmetic compositions containing said powders, and (b) methods for preparing cosmetic compositions containing said powders where the powders have been treated via a volatile organic solvent-free manufacturing process.Type: GrantFiled: May 24, 2004Date of Patent: June 17, 2008Inventors: Jane Hollenberg, Anthony Parker
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Patent number: 7381423Abstract: A description is given of the use of a nanodispersion, which comprises (a) a membrane-forming molecule, (b) a coemulsifier and (c) a lipophilic component, in cosmetic end formulation, which nanodispersion is obtainable by (?) mixing the components (a), (b) and (c) until a homogeneous clear liquid is obtained, and (?) adding the liquid obtained in, step (?) to the water phase of the cosmetic end formulations, steps (?) and (?) being carried out without any additional supply of energy. The nanodispersions used according to this invention can be easily prepared and are suitable as carrier systems for a very wide range of cosmetic active agents and oil-soluble dyes.Type: GrantFiled: April 11, 2005Date of Patent: June 3, 2008Assignee: Ciba Specialty Chemicals Corp.Inventors: Dietmar Hüglin, Joachim Friedrich Röding, Andreas Werner Supersaxo, Hans Georg Weder
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Patent number: 7341735Abstract: An adjuvant is disclosed for use with systemic herbicides, pesticides, insecticides, ovicides and fungicides for application on animals, birds, trees, plants, fruits and vegetables to enhance the action and effect of the systemic herbicides, pesticides, insecticides, ovicides and fungicides. The adjuvant comprises at least one surfactant and at least one high terpene containing natural oil.Type: GrantFiled: August 16, 2003Date of Patent: March 11, 2008Assignee: Oro Agri, Inc.Inventor: Erroll M. Pullen
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Patent number: 7297717Abstract: An oil-in-water type emulsion cosmetic which contains (A) a hydrophilic surface active agent, (B) an oily component and (C) water, and weight ratio of the component (B) is 10 or more based on 1 of the component (A).Type: GrantFiled: April 26, 2001Date of Patent: November 20, 2007Assignee: Kao CorporationInventors: Hidetaka Iwai, Tomohiko Sano
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Patent number: 7294341Abstract: Insecticide and fungicide, and method of application on trees and plants, fruits and vegetables to enhance the growth thereof and to effectively control insects and fungi comprising at least one surfactant and at least one high terpene containing natural oil.Type: GrantFiled: July 1, 2002Date of Patent: November 13, 2007Assignee: Oro Agri, Inc.Inventor: Erroll M. Pullen
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Patent number: 7282196Abstract: The present invention is an antiperspirant product, comprising: (a) an oil-in water microemulsion including an oil phase and a water phase and being substantially free of alcohol, said microemulsion further comprising: one or more oil-in-water emulsifiers selected from the group consisting of polyethoxylated oil-in-water emulsifiers, polypropoxylated oil-in-water emulsifiers and polyethoxylated and polypropoxylated oil-in-water emulsifiers, wherein said microemulsion has a total emulsifier content of less than 20% by weight, based on the total weight of the microemulsion, and one or more antiperspirants, having a total content of 5 to 40% by weight, based on the total weight of the microemulsion, wherein said microemulsion is prepared by bringing a mixture comprising the water phase, the oil phase, and the one or more oil-in-water emulsifiers to a temperature within or above the phase-inversion temperature range, and subsequently cooling it to room temperature, and (b) a pump atomizer, comprising: a coType: GrantFiled: April 6, 2004Date of Patent: October 16, 2007Assignee: Beiersdorf AGInventors: Ulrich Kux, Yvonne Cierpisz, Kurt Mählmann, Norbert Menzel, Khiet Hien Diec
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Patent number: 7282197Abstract: A cosmetic or dermatological composition for preventing excessive odor and sweat secretion by skin, comprising an optically translucent to transparent, substantially alcohol-free oil-in-water type emulsion gel which comprises a polyethoxylated and/or a polypropoxylated O/W emulsifier, a polyol and a antiperspirant. This abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.Type: GrantFiled: July 16, 2004Date of Patent: October 16, 2007Assignee: Beiersdorf AGInventors: Khiet Hien Diec, Ulrich Kux
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Patent number: 7261878Abstract: A topical composition useful for reducing in hair growth includes ?-difluoromethylornithine and a dermatologically acceptable vehicle comprising at least 4% by weight of a polyoxyethylene ether having the chemical formula R(OCH2 CH2)bOH, where R is a saturated or unsaturated alkyl group including from 6 to 22 carbon atoms and b is from 2 to 200.Type: GrantFiled: July 17, 2002Date of Patent: August 28, 2007Assignee: The Gillette CompanyInventors: Peter Styczynski, Gurpreet S. Ahluwalia, Douglas Shander
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Patent number: 7261903Abstract: Lipid emulsion compositions and methods of using such composition via intravenous infusion to reduce the bioavailability and toxicity of poisonous agents in the bloodstream.Type: GrantFiled: February 22, 1999Date of Patent: August 28, 2007Inventors: Guy Weinberg, Paul Hertz
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Patent number: 7235248Abstract: Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or [Nva]2-Ciclosporin, in “microemulsion pre-concentrate” and microemulsion form. The compositions typically comprise (1.1) a C1-5alkyl or tetrahydrofurfuryl di- or partial-ether of a low molecular weight mono- or poly-oxy-alkane diol, e.g. Transcutol or Glycofurol, as hydrophilic component. Compositions are also provided comprising a cyclosporin and (1.1) and, suitably, also a saccharide monoester, e.g. raffinose or saccharose monolaurate. Dosage forms include topical formulations and, in particular, oral dosage forms.Type: GrantFiled: October 2, 2002Date of Patent: June 26, 2007Assignee: Novartis AGInventors: Birgit Hauer, Armin Meinzer, Ulrich Posanski, Friedrich Richter
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Patent number: 7235249Abstract: The present invention relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods each comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of a skin care composition comprising: a) a safe and effective amount of a vitamin B6 compound selected from the group consisting of pyridoxine, esters of pyridoxine, amines of pyridoxine, salts of pyridoxine and derivatives thereof, including pyridoxamine, pyridoxal, pyridoxal phosphate, and pyridoxic acid; b) a safe and effective amount of a skin care active selected from the group consisting of peptides, phytosterol, sugar amines, their derivatives, and combinations thereof; and c) a dermatologically acceptable carrier for the pyridoxine and the skin care active.Type: GrantFiled: March 28, 2002Date of Patent: June 26, 2007Assignee: The Procter & Gamble CompanyInventor: Donald Lynn Bissett
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Patent number: 7226932Abstract: Oral pharmaceutical formulation which improves the bioavailability of pharmaceuticals which are substantially water and oil insoluble is disclosed. In addition to the pharmaceutical, the formulation includes an emulsifier, an oil and an solubilizer. Alternatively, the formulation includes an aqueous solution of solubilizer.Type: GrantFiled: April 29, 2003Date of Patent: June 5, 2007Assignee: G.D. Searle LLCInventors: Rajeev Gokhale, Martin J. Griffin, James E. Truelove, James C. Stolzenbach, Aziz Karim, Ajit K. Roy
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Patent number: 7226584Abstract: Preparations with deodorizing action are provided. The preparations include the zinc salt of ricinoleic acid; amino-functional amino acids; solubility promoters; organic and/or inorganic acids; and, optionally, water.Type: GrantFiled: December 4, 2002Date of Patent: June 5, 2007Assignee: Goldschmidt GmbHInventors: Peter Lersch, Felix Müller, Jörg Peggau, Patrick Ulrich
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Patent number: 7220726Abstract: An antifungal composition suitable for parenteral administration to a mammal includes an amount of pimaricin or an antifungal derivative thereof that is effective to inhibit the growth of a fungal infection in a mammal; a pharmaceutically acceptable dipolar aprotic solvent; and a pharmaceutically acceptable aqueous secondary solvent. The composition can be used in methods of preventing or treating a systemic fungal infection in a mammal. The composition can be prepared by dissolving pimaricin or an antifungal derivative thereof in the pharmaceutically acceptable dipolar aprotic solvent; adding to the solution a pharmaceutically acceptable aqueous secondary solvent; and in a preferred method, by subsequently lypohilizing the composition, whereby a dry, shelf-stable composition is produced. This dry composition can be reconstituted into an aqueous solution suitable for parenteral administration.Type: GrantFiled: May 15, 2003Date of Patent: May 22, 2007Assignee: Board of Regents, The University of Texas SystemInventors: Borje S. Andersson, Elias J. Anaissie
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Patent number: 7220428Abstract: Nanoparticles made from a select group of lipids and optionally containing a therapeutically active agent are employed in pharmaceutical compositions for delivery to targeted tissues and/or cells for the treatment or diagnosis of such diseases as cancer.Type: GrantFiled: October 27, 2004Date of Patent: May 22, 2007Assignee: Cornerstone PharmaceuticalsInventors: Robert Shorr, Robert Rodriguez
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Patent number: 7208143Abstract: What is described herein is an antiperspirant composition including an active antiperspirant ingredient, and a phenylethyl, benzyl or substituted benzyl ester as additive therein, which is an aryl carboxylic ester of 2-phenylethyl alcohol, 1-phenylethyl alcohol or benzyl alcohol, which leaves a reduced visible white chalky residue on the skin of the user.Type: GrantFiled: September 29, 2004Date of Patent: April 24, 2007Assignee: ISP Investments Inc.Inventors: Steven H. Bertz, Steven A. Orofino, Blanca Gomez
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Patent number: 7204976Abstract: The invention is a clear, elastomer-free, gel composition comprising: (a) 14–30 weight % of an antiperspirant active having a low metal to chloride ratio; (b) 7–23.3 weight % of one or more cyclomethicones having a flash point of 100 degrees C. or less; (c) 0.6–0.9 weight % of a silicone surfactant having an HLB value?8; (d) 30–70 weight % water; (e) 3.85–10 weight % of a water soluble glycol or polyglycol and (f) 0.1–3.0 weight % of a non-siliconized organic fragrance solubilizer; wherein the composition is a gel having a viscosity greater than 150,000 centipoise and a ratio of oil phase to water phase in the range of 10:90 to 24:76.Type: GrantFiled: May 30, 2003Date of Patent: April 17, 2007Assignee: Colgate-Palmolive CompanyInventors: Christine Popoff, Suman Chopra, Mardoqueo Bustos, Xiaozhong Tang, Lin Fei
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Patent number: 7205279Abstract: This invention provides a microemulsion pre-concentrate comprising a difficultly soluble active agent and a carrier medium comprising 1) a hydrophilic phase which comprises dimethylisosorbide and/or a lower alkyl alkanoic ester, 2) a lipophilic phase, and 3) a surfactant. The active agent may be a cyclosporin or a macrolide. In another aspect, this invention provides a pharmaceutical composition for enteral or parenteral administration comprising a macrolide and an acid.Type: GrantFiled: December 15, 2000Date of Patent: April 17, 2007Assignee: Novartis AGInventors: Sylvain Cottens, Barbara Haeberlin, Richard Sedrani, Jacky Vonderscher
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Patent number: 7192599Abstract: The present invention relates to cosmetic and pharmaceutical oil-in-water emulsions which have a mattifying effect when applied to the skin. The invention comprises a hydrophilic, non-organically modified magnesium aluminum silicate or a bentonite clay and a polyol in the water phase; and a volatile, skin-compatible, lipophilic solvent and a high melting point lipophilic plasticizer in the oil phase. A preferred surfactant system to stabilize the emulsion includes non-toxic metal alkyl sulfates and/or sucrose esters.Type: GrantFiled: June 3, 2002Date of Patent: March 20, 2007Assignee: MMP, Inc.Inventors: Michel F. Mercier, Paul Thau, John A. Chase
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Patent number: 7192572Abstract: A composition comprising (a) from 0.005% to 0.5% by weight of a cooling compound; (b) from 0.1% to 10% by weight of an emulsifiable substance; (c) from 0.15% to 15% by weight of a surfactant; (d) optionally up to 5% by weight, preferably from 0.05% to 5% by weight of a cosurfactant.Type: GrantFiled: December 18, 2003Date of Patent: March 20, 2007Assignee: Conopco, Inc.Inventors: Ingrid Anne Marie Appelqvist, Mark Emmett Malone, Asish Nandi
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Patent number: 7179880Abstract: A cosmetic and/or pharmaceutical composition containing: (a) a polycarbonate having a molecular weight of from about 300 to 100,000; (b) optionally, an oil component; (c) optionally, an emulsifier; and (d) optionally, water.Type: GrantFiled: November 6, 2002Date of Patent: February 20, 2007Assignee: Cognis Deutschland GmbH & Co. KGInventors: Rolf Kawa, Lars Zander, Alfred Westfechtel
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Patent number: 7179449Abstract: Methods and devices for enhanced ultrasound detection based upon changing temperature and ultrasound reflectivity of a temperature-dependent contrast agent bound to an ultrasound target are disclosed. The methods and devices can be used for enhanced imaging alone or in conjunction with drug delivery, with therapeutic approaches such as hyperthermia or cryotherapy or with other imaging modalities.Type: GrantFiled: January 30, 2001Date of Patent: February 20, 2007Assignee: Barnes-Jewish HospitalInventors: Gregory M. Lanza, Samuel A. Wickline, Christopher S. Hall
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Patent number: 7175836Abstract: A cosmetic water-in-oil composition is provided which includes a water-in-oil emulsifying silicone surfactant, crosslinked silicone elastomer and conjugated linoleic acid. The conjugated linoleic acid functions to improve radiance on facial surfaces to which the composition is topically applied.Type: GrantFiled: December 23, 2005Date of Patent: February 13, 2007Assignee: Conopco, Inc.Inventors: Kelly Denise Hart, Marcina Siciliano, Jeffrey William Rosevear, Brian John Dobkowski
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Patent number: 7175835Abstract: A cosmetic water-in-oil composition is provided which includes a water-in-oil emulsifying silicone surfactant, an ultrafine titanium dioxide and conjugated linoleic acid. The presence of conjugated linoleic acid stabilizes the composition against color degradation and also maintains an approximately steady viscosity.Type: GrantFiled: December 23, 2005Date of Patent: February 13, 2007Assignee: Conopco, Inc.Inventors: Sofia Simoulidis, Jeffrey William Rosevear, Brian John Dobkowski
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Patent number: 7172754Abstract: A cosmetic water-in-oil composition is provided which includes a water-in-oil emulsifying silicone surfactant, organic sunscreen agent and conjugated linoleic acid. The conjugated linoleic acid functions to moderate shine on facial surfaces to which the organic sunscreen agent formulated composition is topically applied.Type: GrantFiled: December 23, 2005Date of Patent: February 6, 2007Assignee: Conopco, Inc.Inventors: Jeffrey William Rosevear, Marcina Siciliano, Brian John Dobkowski, Bivash Ranjan Dasgupta, Lei Huang
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Patent number: 7169819Abstract: A pharmaceutical composition for parenteral delivery, comprising a retinide such as fenretinide in combination with a solvent capable of dispersing or solubilizing the retinide. The solvent comprises an alcohol, such as ethanol, in combination with an alkoxylated castor oil, such as CREMOPHOR® EL, or comprising a retinide, such as fenretinide, in an emulsion composed of a lipoid dispersed in an aqueous phase, a stabilizing amount of a non-ionic surfactant, optionally a solvent, and optionally an isotonic agent. In addition, a method of use in the treatment of hyperproliferative disorders, such as cancers is described.Type: GrantFiled: December 5, 2001Date of Patent: January 30, 2007Assignee: Childrens Hospital Los AngelesInventors: Shanker Gupta, Barry J. Maurer, C. Patrick Reynolds, B. Rao Vishnuvajjala
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Patent number: 7166276Abstract: The present invention relates to silicone elastomer emulsion cosmetic compositions that comprise an internal phase the further includes a colorant. These compositions are intended to deliver such colorant ingredients to the skin of the user in such a manner as to provide a smooth and even colored appearance. In particular, the present invention relates to a cosmetic composition comprising an emulsion that further comprises: a) a continuous aqueous phase comprising: 1) from about 0.1% to about 10%, by weight of the composition, of a non-emulsifying crosslinked siloxane elastomer; b) a dispersed oil phase comprising: 1) from about 1% to about 25%, by weight of the composition, of an oil compatible colorant; and 2) from about 0.01% to about 20%, by weight of the composition, of a binder; and c) from about 0.01% to about 15%, by weight of the composition, of an emulsifier.Type: GrantFiled: October 25, 2002Date of Patent: January 23, 2007Assignee: The Procter & Gamble CompanyInventors: Alison Fiona Stephens, Neil John Jones, Jorge Max Sunkel, Michael Lee Vatter
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Patent number: 7153838Abstract: An antifungal composition suitable for parenteral administration to a mammal includes an amount of pimaricin or an antifungal derivative thereof that is effective to inhibit the growth of a fungal infection in a mammal; a pharmaceutically acceptable dipolar aprotic solvent; and a pharmaceutically acceptable aqueous secondary solvent. The composition can be used in methods of preventing or treating a systemic fungal infection in a mammal. The composition can be prepared by dissolving pimaricin or an antifungal derivative thereof in the pharmaceutically acceptable dipolar aprotic solvent; adding to the solution a pharmaceutically acceptable aqueous secondary solvent; and in a preferred method, by subsequently lypohilizing the composition, whereby a dry, shelf-stable composition is produced. This dry composition can be reconstituted into an aqueous solution suitable for parenteral administration.Type: GrantFiled: October 8, 1999Date of Patent: December 26, 2006Assignee: Board of Regents, the University of Texas SystemInventors: Borje S. Andersson, Elias J. Anaissie
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Patent number: 7132097Abstract: A sunscreen composition which includes at least one UV-B active ingredient therein, optionally with a UV-A active, and a phenylethyl or benzyl ester in an amount sufficient to boost the SPF rating of the UV-B active therein.Type: GrantFiled: October 8, 2004Date of Patent: November 7, 2006Assignee: ISP Investments Inc.Inventors: Steven H. Bertz, Steven A. Orofino, Mihaela Gorcea
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Patent number: 7109247Abstract: In one aspect, the invention provides a stable dispersion comprising a continuous phase comprising a continuous liquid phase and a plurality of organic nanoparticles; and a dispersed phase comprising particles dispersed in the continuous phase.Type: GrantFiled: May 30, 2003Date of Patent: September 19, 2006Assignee: 3M Innovative Properties CompanyInventors: Jimmie R. Baran, Jr., James S. Stefely
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Patent number: 7101928Abstract: Novel thickeners for oil-containing compositions are crystalline polymers, preferably side chain crystalline polymers, which (a) have a crystalline melting point, Tp, and an onset of melting temperature, To, such that Tp?To is less than Tp0.7; (b) are soluble in the oil at temperatures above Tp, and (c) have been dispersed in the oil by a process which comprises (i)dissolving the polymer in the oil at a temperature above Tp, and (ii) cooling the solution from step (i) to crystallize the polymer in the oil.Type: GrantFiled: September 17, 1999Date of Patent: September 5, 2006Assignee: Landec CorporationInventor: Steven P. Bitler
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Patent number: 7097849Abstract: Irritation upon injection of a formulation containing propofol is reduced or substantially eliminated by administering a stable, sterile, and antimicrobial aqueous dispersion comprising a water-insoluble microdroplet matrix of mean diameter from about 50 nm to about 1000 nm consisting essentially of about 1% to about 15% of propofol, up to about 7% of a propofol-soluble diluent, and about 0.8% to about 4% of a surface stabilizing amphiphilic agent. The aqueous phase includes a pharmaceutically acceptable water-soluble polyhydroxy tonicity modifier. The propofol-containing dispersion is devoid of additional bactericidal or bacteriostatic preservative agents.Type: GrantFiled: August 18, 1999Date of Patent: August 29, 2006Assignee: Jagotec AGInventors: Awadhesh K. Mishra, Gary W. Pace, Michael G. Vachon
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Patent number: 7094395Abstract: A method for producing a colored cosmetic composition having inorganic pigments resistant to agglomeration in an oil-in-water emulsion. The method includes the following: preparing an oil dispersion by adding inorganic pigments directly to an oil; preparing an aqueous base that includes water; combining the oil dispersion and aqueous base; and partitioning the inorganic pigments between the oil and the aqueous phase under controlled conditions, for example, hydrophile-lipophile balance, agitation time and speed, and cooling rate. The present invention provides a process to easily disperse iron-oxide pigments, even black iron-oxide pigments, in oil-in-water emulsions. The present invention provides colored cosmetic compositions that have excellent properties, such as smoothness, adhesion to skin, uniform color, ease of removal, smudge resistance and non-oiliness.Type: GrantFiled: April 25, 2002Date of Patent: August 22, 2006Assignee: Access Business Group International LLCInventors: Di Qu, Jesse C. Leverett
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Patent number: 7081253Abstract: A description is given of the use of a nanodispersion, which comprises (a) a membrane-forming molecule, (b) a coemulsifier and (c) a lipophilic component, in pharmaceutical end formulations, the nanodispersion being obtainable by (?) mixing the components (a), (b) and (c) until a homogeneous clear liquid is obtained, and (?) adding the liquid obtained in step (?) to the water phase of the pharmaceutical end formulations, steps (?) and (?) being carried out without any additional supply of energy. The nanodispersions used according to this invention are suitable as transport vehicles for pharmaceutical active agents.Type: GrantFiled: May 6, 1999Date of Patent: July 25, 2006Assignees: Ciba Specialty Chemicals Corporation, Vesifact AGInventors: Andreas Werner Supersaxo, Hans Georg Weder, Dietmar Hüglin, Joachim Friedrich Röding
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Patent number: 7078060Abstract: Solutions and aerosols of metal-containing compounds are disclosed. Methods of preparing and using the solutions and aerosols, particularly in the treatment of a subject having a condition, are also disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.Type: GrantFiled: February 12, 2003Date of Patent: July 18, 2006Assignee: Nucryst Pharmaceuticals Corp.Inventors: Robert E. Burrell, John B. Wright, Kan Lam, Hua Qing Yin, Antony G. Naylor, Peter H. Moxham, Scott H. Gillis, Paul Schechter
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Patent number: 7067153Abstract: A process for making hydrophobicized powders of micro- and/or nanocapsules involving the steps of: (a) providing an aqueous polymer solution containing at least one active ingredient and at least one hydrophilic polymer; (b) providing an oil component heated to a temperature above a gel point of the aqueous polymer solution; (c) dispersing (a) in (b) in the presence of a water-in-oil emulsifier to form a dispersion; (d) cooling the dispersion to a temperature below the gel point of the aqueous polymer solution to form micro- and/or nanocapsules containing the active ingredient encapsulated therein; (e) harvesting the micro- and/or nanocapsules from the dispersion; and (f) contacting the micro- and/or nanocapsules with an oil-absorbing auxiliary ingredient.Type: GrantFiled: September 18, 2001Date of Patent: June 27, 2006Assignee: Cognis France S.A.Inventor: Philippe Grisoni
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Patent number: 7041305Abstract: A water in oil emulsion system and a process for preparing such a emulsion has been provided for topically applying aminophylline for reducing cellulite conditions.Type: GrantFiled: August 29, 2002Date of Patent: May 9, 2006Assignee: Western Holdings, LLCInventor: Kenneth Shirley
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Patent number: 7041705Abstract: Irritation upon injection of a formulation containing propofol is reduced or substantially eliminated by administering a stable, sterile, and antimicrobial aqueous dispersion comprising a water-insoluble microdroplet matrix of mean diameter from about 50 nm to about 1000 nm consisting essentially of about 1% to about 15% of propofol, up to about 7% of a propofol-soluble diluent, and about 0.8% to about 4% of a surface stabilizing amphiphilic aent. The aqueous phase includes a pharmaceutically acceptable water-soluble polyhydroxy tonicity modifier. The propofol-containing dispersion is devoid of additional bactericidal or bacteriostatic preservative agents.Type: GrantFiled: March 26, 2001Date of Patent: May 9, 2006Assignee: Jagotec AGInventors: Awadhesh K. Mishra, Gary W. Pace, Michael G Vachon
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Patent number: 7029656Abstract: Formulations, methods and devices for producing formulations and methods for nebulizer delivery of formulations of water-insoluble drugs are provided. Also provided are methods for minimizing wastage of drugs administered by nebulizer, and for the achievement of quantitative dosing with diluent from a mass marketed formulations, which because of the mass market is much less costly per dose than formulations manufactured specifically for much lower volume medical use.Type: GrantFiled: December 15, 2000Date of Patent: April 18, 2006Inventor: Robert E. Coifman