Abstract: A pharmaceutical composition in the form of a microemulsion preconcentrate comprising a cyclosporin dissolved in a solvent system further comprising a hydrophobic component, a hydrophilic component, and a surfactant, wherein either the hydrophobic component is selected from tocol, tocopherols, tocotrienols, and derivatives thereof, or the hydrophilic component is selected from propylene carbonate or polyethylene glycol having an average molecular weight of less than 1000.

Abstract: The cosmetic preparation contains: (a) an oil-soluble active ingredient that is suitable for skin cosmetics, (b) a partial fatty acid ester of polyoxyethylene sorbitan, (c) at least one phospholipid, (d) ethanol, and (e) water as a carrier liquid. The phospholipid is dissolved in ethanol, and then the partial fatty acid esters of polyoxyethylene sorbitan and the active ingredient are added. The oil phase that is obtained is added to water and stirred. The preparation is obtained in the form of a nanodispersion.

Abstract: Disclosed are topical compositions which are useful for providing essentially immediate improvements in skin appearance, e.g., good coverage of skin imperfections, e.g., pores and uneven skin tone, in addition to chronic improvements in skin appearance, while retaining a natural skin appearance. The compositions contain a particulate material having a refractive index of at least about 2, e.g., TiO.sub.2, and an active for regulating skin condition following multiple topical applications of the composition. Preferred actives include Vitamin B.sub.3 compounds and retinoids.

Abstract: A composition containing, in a suitable carrier, nanoparticles of one or more nonbiodegradable polymer(s) encapsulating an oily phase which contains at least one active oil and/or at least one carrier oil and/or at least one active ingredient in an active oil and/or a carrier oil. At least one active ingredient is chosen from those with prolonged cosmetic and/or pharmaceutical activity. The nanocapsules have a size of 100-1000 nm.

Abstract: A composition for application to solid, keratinous surfaces comprising 0.01-80% of a thio-free keratinous protein cross-linking agent, 1-75% of a solvent, and 0.01-35% of a film former, and a method for strenghthening keratinous surfaces by applying the composition of the invention.

Abstract: The invention relates to novel methods for making oil-in-water emulsions having mucoadhesive properties which are primarily intended for administration of biologically active compounds to mucosal surfaces. The emulsion has an aqueous continuous phase and a plurality of submicron particles having an average particle diameter of from 10 nm to 600 nm, with the particles having a hydrophobic phase of a fat or oil which forms a hydrophobic core that is surrounded by a surfactant layer. The emulsion further includes a mucoadhesive polymer which is a polymer or copolymer of acrylic acid or methacrylic acid, a poly (methyl vinyl ether/maleic anhydride) copolymer, pectin, alginic acid, hyaluronic acid, chitosan, gum tragacanth, karaya gum or carboxymethylcellulose surrounding the hydrophobic one. A biologically active compound may also be included, if desired.

Abstract: A stable, water-thin emulsion is formed by processing a crude emulsion through a high pressure homogenizer at a pressure of about 900 to about 1100 bar. This emulsion contains low levels of emulsifier and contains no post addition stabilizers.

Abstract: A dermatologically compatible substantive oil-in-water sunscreen composition is disclosed comprising a block polymer substantive agent and a sunscreening agent. The composition is adaptable for dispensing by a spray means.

Abstract: A heat and shelf-stable oil-in-water emulsion useful as a tissue or cell-selective delivery vehicle. Radioactive or stable, synthetic or semi-synthetic polyhalogenated triglycerides, such as 2-oleoylglycerol-1,3-bis[7-(3-amino-2,4,6-triiodophenyl)heptanoate] or 2-oleoylglycerol-1,3-bis[.omega.-(3,5-bis-trifluoromethyl)hepatanoate] or phenyl acetate, can be incorporated into the lipophilic core of a lipoprotein-like emulsion particle. The lipophilic core is surrounded by a phospholipid membrane comprising cholesterol and apolipoproteins. For hepatocyte-selective delivery, the emulsion is chylomicron remnant-like by being in a size range of 50 to 200 nm as measured by number weighting analysis with a narrow size distribution (<2% greater than 300 nm) and having a composition simulating naturally-occurring chylomicron remnants. Use of cholesterol in the emulsion formula facilitates association of apolipoproteins, especially Apo E which are recognized by liver cells and necessary for binding and uptake.

Abstract: A fluid composition is provided in the form of a wax dispersion in a liquid vehicle which is comprised of a single phase. The dispersed phase is a stable microdispersion comprised of particles having a size lower than 0.5 .mu.m. The particles are constituted essentially of a mixture of at least one wax, at least one emulsifying agent and optionally at least one oil and/or at least one liposoluble active ingredient. This mixture has a end melting point greater than 50.degree. C. and lower than 100.degree. C. The composition contains, by weight, from 0.1 to 40% of wax and from 0.01 to 25% of emulsifying agent. The emulsifying agent is a cationic emulsifier. The concentration of oil, when it is present, is less than or equal to 30 weight percent relative to the weight of the wax or mixture of waxes.

Abstract: Disclosed herein is an oil-in-water type cosmetic composition containing retinoids stabilized within a core of a liquidcrystal formed by a surfactant having a phase transition temperature of 45.degree. C. or higher and a bulky structure.

Abstract: Multiple emulsions comprising a discontinuous emulsified phase incorporating a highly polar liquid, a second component selected from the group consisting of fluorocarbons and hydrocarbons and a continuous hydrophobic phase are disclosed. In preferred embodiments, the hydrophobic phase may comprise a fluorocarbon or hydrocarbon. Additionally, the stable multiple emulsions of the present invention may further incorporate a bioactive agent and are particularly suitable for drug delivery including pulmonary drug delivery.

Abstract: Skin care compositions comprising an oil-in-water emulsion base containing retinoids and possessing good physical and chemical stability. More particularly, said skin care compositions contain (a) an emulsifier system selected from the group consisting of: (i) a mixture of glyceryl stearate and polyethylene glycol 100 stearate; (ii) cetearyl alcohol and cetearyl glucoside; (iii) a mixture of a polyethylene glycol ethers of stearyl alcohol; and (iv) a mixture of sorbitan stearate and polysorbate 60; (b) a co-emulsifier selected from the group consisting of cetyl alcohol, stearyl alcohol and mixtures thereof; (c) an oil phase present in the amount of from about 5 to about 20 percent by weight of the total emulsion composition which contains (i) a light, dry absorbable oil and (ii) substantive, emollient oils or waxes, wherein the light, dry absorbable oil and the substantive oil or wax are present in a ratio of from about 1:3 for about 10:1.

Abstract: Disclosed are topical compositions which provide good coverage of skin imperfections, e.g., pores and uneven skin tone, while retaining a natural skin appearance. The compositions contain a particulate material having a refractive index of at least about 2, e.g., TiO.sub.2.

Abstract: The present invention relates to a new cosmetic skin-care product for external use, which is based on UV-radiation-absorbing substances in combination with a free-radical scavenger system.

Abstract: The present invention relates to stable water-containing cosmetic or pharmaceutical compositions which comprise a biologically active agent and an enzyme-based oxygen-scavenging antioxidant system. The composition preferably comprises an antioxidant system comprising effective amounts of an oxidase, a substrate for the oxidase, and a peroxidase, and at least one species oxidizable by hydrogen peroxide, such as iodide and/or thiocyanate anions.

Abstract: Stable, topically applicable cosmetic/dermatological compositions well suited for artificially tanning or browning human skin and appropriately packaged, comprise at least one dihydroxyacetone (DHA) derivative convertible into DHA and, advantageously, at least one active species for effecting such conversion.

Abstract: The invention relates to the use of an ethylenediamine derivative as a substance P antagonist and/or as a local analgesic in, or for the preparation of, a cosmetic or dermatological composition for treating sensitive skin-types. The invention relates in particular to the use of this derivative for preventing and/or combating skin irritations and/or dartres and/or erythema and/or dysaesthesic sensations and/or sensations of inflammation and/or pruritus of the skin and/or the mucous membranes including the eyes. The invention also relates to a composition containing a product having an irritant side effect and this derivative, so as to reduce this irritant effect or even to remove it altogether.

Abstract: Relatively high VOC hair styling compositions which provide good style retention without unacceptable stickiness or stiffness are disclosed. The compositions comprise from about 0.01% to about 20% of a hair styling polymer and a carrier comprising at least about 0.5%, by weight of the composition, of a first solvent selected from the group consisting of water; water soluble organic solvents; organic solvents which are strongly to moderately strong in hydrogen-bonding parameter; and mixtures thereof; wherein the first solvent is other than a C.sub.1 -C.sub.3 monohydric alcohol, a C.sub.1 --C.sub.3 ketone and a C.sub.1 -C.sub.3 ether, wherein the composition is characterized by a FFV and a CRI wherein (FFV.sup.-1 .times.1000).gtoreq.[(-2.635.times.CRI)+36.418].

Abstract: Topically applicable sunscreen/cosmetic compositions well suited for enhanced photoprotection of human skin and/or hair against the damaging effects of UV-A and UV-B irradiation, particularly solar radiation, comprise a photoprotecting synergistically effective amount of (i) 2,4,6-tris[p-((2'-ethylhexyl)oxycarbonyl)anilino]-1,3,5-triazine and (ii) 2-ethylhexyl .alpha.-cyano-.beta.,.beta.-diphenylacrylate, in a cosmetically acceptable vehicle, diluent or carrier therefor.

Abstract: A self-emulsifying oily formulation (SEOF) comprising an oil component and a surfactant, the SEOF being characterized in that the oil component comprises an oily carrier and a cationic lipid and optionally, a lipophilic oily fatty alcohol, the oil-in-water emulsion which forms upon mixture of the SEOF, having oily droplets which are positively charged.

Abstract: A cosmetic composition having improved transfer resistance comprising:a) from about 0.1-60% by weight of triethylated silica,b) from about 0.1-60% by weight of a volatile solvent having a viscosity of 0.5 to 100 centipoise at 25.degree. C.,c) 0.1-60% by weight of a nonvolatile oil having a viscosity of 200 to 1,000,000 centipoise at 25.degree. C.d) 0.1-80% of a cosmetically acceptable carrier.

Abstract: A medicament for use in the treatment of anorectal inflammation in hemorrhoids and the like contains a petroleum base, water, phenylephrine hydrochloride, squalene, and 8-hydroxyquinoline.

Abstract: Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or ?Nva!.sup.2 -Ciclosporin, in "microemulsion pre-concentrate" and microemulsion form. The compositions typically comprise (1.1) a C.sub.1-5 alkyl or tetrahydrofurfuryl di- or partial-ether of a low molecular weight mono- or poly-oxy-alkane diol, e.g. Transcutol or Glycofurol, as hydrophilic component. Compositions are also provided comprising a cyclosporin and (1.1) and, suitably, also a saccharide monoester, e.g. raffinose or saccharose monolaurate. Dosage forms include topical formulations and, in particular, oral dosage forms.

Abstract: Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or ?Nva!.sup.2 -Ciclosporin, in "microemulsion pre-concentrate" and microemulsion form. The compositions typically comprise (1.1) a C.sub.1-5 alkyl or tetrahydrofurfuryl di- or partial-ether of a low molecular weight mono- or poly-oxy-alkane diol, e.g. Transcutol or Glycofurol, as hydrophilic component. Compositions are also provided comprising a cyclosporin and (1.1) and, suitably, also a saccharide monoester, e.g. raffinose or saccharose monolaurate. Dosage forms include topical formulations and, in particular, oral dosage forms.

Abstract: A multiple emulsion to administer at least one water-soluble or liposoluble active ingredient in the form of a water/oil/water emulsion comprising a dispersed phase of a water/oil type and an aqueous dispersion medium which is a gelled aqueous phase useful as cosmetic compositions for external skin application.

Abstract: The present invention relates to the use of fatty alcohol based compositions comprising:60 to 90% by weight of at least one fatty alcohol having from 12 to 22 carbon atoms, preferably from 16 to 18 carbon atoms,10 to 40% by weight of an alkylpolyoside, preferably an alkylpolyoside of which the alkyl part is identical to that of the fatty alcohol,and, if appropriate, 0.5 to 5% of polyoside, for preparing emulsions.The invention finds an application in particular for preparing emulsions in the cosmetic and pharmaceutical fields.

Abstract: A lotion such as a sunscreen includes a color indicator which colorizes the lotion until the lotion is applied to human skin, whereinafter the colored lotion changes color or turns clear. A physiological color indicator such as a pH indicator, a colorant, or a water-soluble dye such as coumarin can be used, alone or in combination, to colorize the lotion in accord with the invention. The lotion is suitable for use in any lotion, gel, mousse or medication that is best applied in an even and uniform manner to the skin. Accordingly, one preferred use of the invention is in UV-protection sunscreens so that a user can ensure even distribution of the sunscreen on the body. A sunscreen of the invention can also include an emollient, such as jacoba oil, an emulsifier, a surfactant, such as sorbitol, water, and a pH adjuster, such as triethanolamine.

Abstract: A dispersion of a water-immiscible phase, in an external aqueous phase by means of lipid vesicles comprising at least one silicone surfactant, for the treatment of the skin, the mucous membranes, the nails, the scalp and the hair and in particular, greasy skin.

Abstract: A lotion such as a sunscreen includes a pH indicator which colorizes the lotion until the lotion is applied to the human skin, whereinafter the colored lotion turns clear. A physiologically compatible pH indicator such as phenolphthalein is used which has a red appearance from pH 7.5+ and which has a clear appearance from about pH 7.0 to 7.5, the general pH range of the skin. The invention is suitable for use in any lotion, gel, mousse or medication that is best applied in an even and uniform manner to the skin. Accordingly, one preferred use of the invention is in UV-protecting sunscreens so that a user can ensure even distribution of the sunscreen on the body. In certain aspects of the invention, a cap houses the pH indicator and attaches to a container of the lotion, e.g., a sunscreen. The pH indicator mixes with the lotion as it is applied to the skin.

Abstract: The present invention is a method for enhancing the analgesic efficacy of a locally applied opioid analgesic or local anesthetic agent in a mammal having an impermeable perineurium barrier sheet about the peripheral sensory nerves at the site of action of the analgesic or anesthetic agent. The method involves applying to that site an effective amount of the analgesic or anesthetic agent dissolved in a hyperosmolar solution having an osmolality of above 300 mOsm/l.

Abstract: A process for thickening a water-in-oil and oil-in-water emulsion involving adding to the emulsion a thickening agent consisting of an alkyl or alkenyl oligoglucoside ester formed by esterifying an alkyl or alkenyl oligoglycoside corresponding to formula I:R.sup.1 O--?G!.sub.p (I)wherein R.sup.1 is an alkyl or alkenyl oligoglucoside containing from about 4 to about 22 carbon atoms, G is a sugar unit containing from 5 to 6 carbon atoms, and p is a number having a value of from 1 to about 10, with a fatty acid corresponding to formula II:R.sup.2 CO--OH (II)wherein R.sup.2 CO is an aliphatic acyl radical containing from about 6 to about 22 carbon atoms, and up to about 3 double bonds.

Abstract: The present invention relates to topical compositions comprising a vitamin B.sub.3 compound which are useful for regulating skin condition, especially for regulating the signs of skin aging.

Abstract: An emulsion comprising an oily phase dispersed in an aqueous phase with the aid of a silicone emulsifying agent, the oily phase comprising at least 50% by weight of silicone oil and the aqueous phase containing at least one polyol in a quantity which imparts a water activity value to the emulsion of .ltoreq.0.85.

Abstract: The inventive compositions contain an oil-in-water and a water-in-oil emulsion, each buffered to a specific pH, so that the difference in pH values of the two emulsions is at least two units. The molecular mixing is minimized by selecting suitable oil and oil phase in a water-in-oil emulsion. The change in pH is further minimized by buffering each emulsion. The particular advantage of the inventive compositions is the ability to separate within a single composition, with minimal intermixing, active compounds which require different pH environments for stability and/or optimum efficacy.

Abstract: A pharmaceutical composition containing macrolide, e.g. a rapamycin compound in an emulsion preconcentrate or microemulsion preconcentrate for oral administration. The carrier medium for the rapamycin compound includes a hydrophilic phase, a lipophilic phase and a surfactant. The composition is stable and provides high absorption efficiency.

Abstract: Described are the use of compounds of Formula (I), depicted below, as active principals for treating skin conditions; compositions containing these compounds; and methods of treating skin conditions using these compounds and compositions. ##STR1## wherein R.sub.4 is (CR.sub.5 R.sub.6 --CR.sub.7 R.sub.8 --X.sub.1).sub.n --CR.sub.9 R.sub.10 --C(.dbd.X.sub.2)X.sub.3 R.sub.11, n is an integer from 1 to 18; R.sub.1, R.sub.2, R.sub.3, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11, are independently, hydrogen or non-hydrogen substituents; and X, X.sub.1, X.sub.2, X.sub.3, Y and Z are independently, O, NH, or S.

Abstract: A stable oil-in-water emulsion suitable for parenteral administration, containing less than 10% by weight lecithin, consisting of an aqueous phase and of an oil phase which is very finely dispersed by means of a physiologically tolerated emulsifier and which contains at least one carotenoid and is based on a physiologically tolerated oil or fat and comprises as emulsifier polyoxyethylene/polyoxypropylene block polymers and/or lecithin, and wherein the carotenoid is present in the oil phase in a concentration above the saturation solubility of the carotenoid in the oil or fat at room temperature.

Abstract: An oil-in-water emulsion with oil globules with a mean size of no greater than 150 nm, comprising an amphiphilic lipid phase comprising at least one nonionic amphiphilic lipid which is liquid at an ambient temperature of less than 45.degree. C., at least one oil and at least one aminated silicone, as well as to its uses in the cosmetic or dermopharmaceutical field.

Abstract: The present invention relates to a cosmetic or dermatological composition comprising an emulsion of oil-in-water type formed of oily globules which are each provided with a lamellar liquid crystal coating and are dispersed in an aqueous phase. Each oily globule containing at least one lipophilic compound which is cosmetically or dermatologically active is individually coated with a monolamellar or aligolamellar layer obtained from at least one lipophilic surface-active agent, from at least one hydrophilic surface-active agent and from at least one ionic amphiphilic lipid imparting to the emulsion a pH ranging from 5.5 to 7.5, the coated oily globules having a mean diameter of less than 500 nanometers.

Abstract: Concentrated aqueous liquid disinfectant compositions which exhibit a blooming effect when diluted in a larger volume of water are provided. The concentrate compositions include non-phenolic constituents to provide a disinfecting effect, and are non pine-oil containing. Working strength dilutions of the concentrated aqueous liquid disinfectant compositions are effective against gram positive type pathogenic bacteria such as Staphylococcus aureus, as well as gram negative type pathogenic bacteria such as Salmonella choleraesuis.

Abstract: Cosmetic, hygienic or dermopharmaceutical composition characterized in that it comprises, in combination, at least one superoxide-dismutase and at least one melanin pigment. In such a composition the melanin pigment reinforces synergistically the action of the SOD against free radicals. Application especially to combating cell aging and to the protection of the skin, of the hair and of the mucosa against the harmful and unaesthetic effects caused by free radicals.

Abstract: An apparatus, product formulation, and method for improved dermal permeation of pharmaceuticals wherein the apparatus includes a thin drug formulation reservoir and a heat-generating chamber separated by a first non-permeable wall, wherein the reservoir and chamber are formed in or supported by a housing. The drug formulation reservoir houses or is capable of housing a predetermined amount of a formulation containing pharmaceutically-active agent(s). The heat-generating/temperature-regulating chamber includes a medium for generating controlled heat, preferably a chemical composition made of carbon, iron, water and/or salt which is activated upon contact with air (oxygen).

Abstract: Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or ?Nva!.sup.2 -Ciclosporin, in "microemulsion pre-concentrate" and microemulsion form. The compositions typically comprise (1.1) a C.sub.1-5 alkyl or tetrahydrofurfuryl di- or partial-ether of a low molecular weight mono- or poly-oxy-alkane diol, e.g. Transcutol or Glycofurol, as hydrophilic component. Compositions are also provided comprising a cyclosporin and (1.1) and, suitably, also a saccharide monoester, e.g. raffinose or saccharose monolaurate. Dosage forms include topical formulations and, in particular, oral dosage forms.

Abstract: Use of (a) one or more cosmetically or pharmaceutically acceptable hydrophobic inorganic pigments for achieving or increasing the water resistance of cosmetic or dermatological light protection formulations which are in the form of O/W emulsions or W/O emulsions, (b) the hydrophobic inorganic pigments being incorporated into the oily phase of the O/W emulsions or W/O emulsions, and comprise (c) one or more UV filter substances which carry one or more sulphonic acid groups or sulphonate groups on their molecular skeleton, and (d) one or more surface-active substances chosen from the group consisting of glucose derivatives and which (e) are essentially free from polyethoxylated emulsifiers.

Abstract: The invention provides a method for enhancing learning in a person by the administration of a mixed-floral odorant. The odorant can be used as an adjuvant to improve learning and as an aid in education, and for rehabilitation of patients diagnosed with pathologically-induced learning disabilities.

Abstract: Stable reverse water-in-fluorocarbon emulsions and water-in-fluorocarbon-in-water multiple emulsions comprising the reverse fluorocarbon emulsions. The reverse emulsions comprise a continuous phase which is a highly fluorinated or perfluorinated compound, a discontinuous aqueous phase and a fluorinated surfactant or mixture of surfactants. The multiple emulsions comprise an aqueous continuous phase and a discontinuous phase comprising globules formed of aqueous droplets dispersed into a highly fluorinated or perfluorinated compound. The emulsions can contain pharmacologically active agents, and are particularly suitable for pulmonary drug delivery.

Abstract: A cosmetic or pharmaceutical composition containing an emulsifier comprising an ester of palmitic acid and technical grade triglycerol with the proviso that the monoester content of the ester is from 30% to 50% by weight.

Abstract: A pharmaceutical preparation comprising a stable, surface-active emulsion or dispersion of a pharmaceutical agent incorporated into an emulsion (i) having a hydrophobic discontinuous phase of a long chain carboxylic acid or ester or alcohol thereof dispersed in an aqueous phase or (ii) having a hydrophilic discontinuous phase dispersed in a hydrophobic phase of a long chain carboxylic acid or alcohol thereof. The emulsion with pharmaceutical agent is incorporated into a pharmaceutical carrier suitable for oral delivery.

Abstract: Topically applicable pharmaceutical/dermatological/cosmetic compositions, well suited for the therapeutic treatment of neurogenic red skin blotches and rosacea afflicting the skin, scalp and/or mucosae of a human subject, comprise a therapeutically/cosmetically effective amount of at least one TNF-alpha antagonist.