Polyoxyalkylated Compound Containing Patents (Class 514/941)
  • Patent number: 5326553
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract whereinZ=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxycarbonyloxy, (CR.sub.1 R.sub.2).sub.p-- (CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.
    Type: Grant
    Filed: February 2, 1993
    Date of Patent: July 5, 1994
    Assignee: Sterling Winthrop Inc.
    Inventors: Carl R. Illig, Eugene R. Cooper, John L. Toner, Donald A. Upson, Brent D. Douty, Thomas J. Caulfield, Bacon, Edward R., Kimberly G. Estep, Kurt A. Josef, Shaughnessy Robinson, Paul P. Spara
  • Patent number: 5318960
    Abstract: Compositions for pain relieving non-steroidal anti-inflammatory drugs and/or medicaments such as ibuprofen, methotrexate, capsaicin, diphenhydramine, aspirin, methylnicotinate and other medicaments largely soluble in oil, alcohol, and/or water, are produced for transdermal delivery. The composition is manufactured by admixing an appropriate amount of oil surfactant with an appropriate amount of pharmaceutically approved co-solubilizer alcohol to establish a non aqueous phase. The oil surfactant may be a polyethoxylated oil such as castor oil. The co-solubilizer may be isopropyl alcohol or virtually any other alcohols except for methanol. Thereafter, an appropriate amount of distilled water is slowly added to the homogeneous or non-aqueous phase to further reduce viscosity. The final admixture is a clear, oil-continuous solution having a viscosity no greater than 850 centistokes as measured by the VST Hoppler method at 25 degrees Celsius.
    Type: Grant
    Filed: June 3, 1992
    Date of Patent: June 7, 1994
    Assignee: Frank Toppo
    Inventor: Frank Toppo
  • Patent number: 5318768
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material in combination with a divalent cation capable of forming a coating on the gastrointestinal tract and a crystalline contrast agent in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
    Type: Grant
    Filed: February 17, 1993
    Date of Patent: June 7, 1994
    Assignee: Sterling Winthrop Inc.
    Inventors: Carl R. Illig, Eugene R. Cooper
  • Patent number: 5316755
    Abstract: Disclosed are contrast agents of the formula ##STR1## contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract whereinZ=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy,(CR.sub.1 R.sub.2).sub.p -(CR.sub.3 =CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p -C.ident.C-Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently lower-alkyl, optionally substituted with halo;x is 1-4;n is 1-5;m is 1-15;p is 1-10; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl.
    Type: Grant
    Filed: February 2, 1993
    Date of Patent: May 31, 1994
    Assignee: Sterling Winthrop Inc.
    Inventors: Carl R. Illig, Eugene R. Cooper, John L. Toner, Donald A. Upson, Brent D. Douty, Thomas J. Caulfield, Edward R. Bacon, Kimberly G. Estep, Kurt A. Josef, Shaughnessy Robinson, Paul P. Spara
  • Patent number: 5312616
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula ##STR1## wherein Z=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxycarbonyloxy, (CR.sub.1 R.sub.2).sub.p --(CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently lower-alkyl, optionally substituted with halo;x is 1-3y is 1-4;n is 1-5;m is 1-15;p is 1-10; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl.
    Type: Grant
    Filed: March 11, 1993
    Date of Patent: May 17, 1994
    Assignee: Sterling Winthrop Inc.
    Inventors: Carl R. Illig, Brent D. Douty
  • Patent number: 5310538
    Abstract: R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, ##STR2## or halo-lower-alkyl, each of which may be optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy, (CR.sub.1 R.sub.2).sub.p --(CR.sub.3 =CR.sub.4).sub.m Q ,or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q;R.sub.1, R.sub.2 and R.sub.3 and R.sub.4 are independently H, or lower-alkyl, optionally substituted with halo;x is 1-4;n is 1-4;m is 1-15;p is 1-20; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkylThese compounds are combined in a polymer for use as an X-ray contrast agent.
    Type: Grant
    Filed: March 11, 1993
    Date of Patent: May 10, 1994
    Assignee: Sterling Winthrop Inc.
    Inventors: Edward R. Bacon, Carl R. Illig, Thomas J. Caulfield, Brent D. Douty, Kurt A. Josef
  • Patent number: 5302658
    Abstract: A method is described for making an emulsion in which a mixture is formed containing a polysiloxane and a primary nonionic surfactant having an HLB value of 10 to 19. There is added to the mixture a first portion of surfactant free water gradually in a series of separate incremental steps. This is followed by the addition to the mixture of a secondary nonionic surfactant having an HLB value of 1.8-15. The mixture is stirred until the particle size of the polysiloxane in the mixture is in the range of 1-100 microns. A second portion of water is added to the mixture in an amount sufficient to provide a total content of water in the product of 25-65 percent by weight.
    Type: Grant
    Filed: July 14, 1992
    Date of Patent: April 12, 1994
    Assignee: Dow Corning Corporation
    Inventors: Ronald P. Gee, Padmakumari J. Varaprath
  • Patent number: 5292503
    Abstract: There is described water-in-oil emulsions containing polysiloxane surface active agents which can be formulated into lotions for use in sunscreens and skin care products.
    Type: Grant
    Filed: October 9, 1991
    Date of Patent: March 8, 1994
    Assignee: General Electric Company
    Inventors: William J. Raleigh, Raymond J. Thimineur
  • Patent number: 5290565
    Abstract: Composition for promoting healing containing, as a healing agent, nonionic vesicles obtained from a lipid mixture containing at least one nonionic lipid having the formula; ##STR1## wherein R is either at least one C.sub.16 -C.sub.18 radical, or R'CO wherein R' is at least one C.sub.15 -C.sub.17 alkyl radical, in combination with cholesterol and, optionally, dicetylphosphate or tetracetylphospate.This composition can be used topically to accelerate the scarring of wounds.
    Type: Grant
    Filed: May 13, 1992
    Date of Patent: March 1, 1994
    Assignee: L'Oreal
    Inventors: Alexandre Zysman, Henri Sebag, Guy Vanlerberghe, Rose-Marie Handjani, Alain Ribier
  • Patent number: 5260049
    Abstract: Disclosed are aqueous compositions containing a contrast agent of the formula ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract, wherein R is a substituted or unsubstituted alkyl group containing from 2 to 8 carbon atoms, wherein said substituents are selected from the group consisting of C.sub.1 -C.sub.6 alkyl, hydroxy and alkoxy; and n is 1 to 5.
    Type: Grant
    Filed: May 1, 1992
    Date of Patent: November 9, 1993
    Assignee: Sterling Winthrop Inc.
    Inventors: Carl R. Illig, John L. Toner
  • Patent number: 5256422
    Abstract: The present invention features water-in-oil emulsions having intact lipid vesicles dispersed in the water or aqueous phase. Methods of making the emulsions are also disclosed. The preferred vesicles for use in the emulsions are paucilamellar lipid vesicles, most preferably those having nonionic amphiphiles as their major structural component. The water-in-oil emulsions are useful in cosmetics, pharmaceuticals, and foods such as margarine.
    Type: Grant
    Filed: July 8, 1992
    Date of Patent: October 26, 1993
    Assignee: Micro Vesicular Systems, Inc.
    Inventors: Elizabeth C. Albert, Donald F. H. Wallach, Rajiv Mathur
  • Patent number: 5246694
    Abstract: A shampoo composition comprises:(a) a surfactant which is chosen from anionic, nonionic or amphoteric surfactants or mixtures thereof;(b) an aqueous emulsion of a solution of highly viscous silicone in volatile solvent; and(c) a cationic conditioning polymer which is a cationic derivative of guar gum;wherein the average particle size of the highly viscous silicone in the composition is less than 2 .mu.m in diameter.
    Type: Grant
    Filed: July 22, 1991
    Date of Patent: September 21, 1993
    Assignee: Chesebrough-Pond's USA Co., Division of Conopco, Inc.
    Inventor: David H. Birthwistle
  • Patent number: 5242907
    Abstract: Tropical and temperate crops, particularly rice, maize, cotton, soya and fruit, can be protected, particularly against insect pests of the orders Leoidoptera, Diptera, Coleoptera, Hemiptera, Orthoptera, Dictyoptera, Hymenoptera and Isoctera and acarine pests, by treatment with a pesticidal water-miscible formulation whose average particle size is at most 200 nm. Public health pests, including the house fly (Musca domestica), cockroach (Blatta sp. or Periplaneta sp.) and mosquito (Aedes aegyoti) as well as pests which infest or affect timber, particularly in buildings, can also be controlled with such formulations. The formulations include water, oil, a surfactant, and a cosurfactant, wherein either the oil is a pesticide or the formulation comprises a pesticide dissolved in the oil. The pesticide may be a pyrethroid such as cypermethrin or deltamethrin. The formulations can be molecular solutions, micellar solutions or microemulsions (water-in-oil or oil-in-water) and are generally clear.
    Type: Grant
    Filed: April 29, 1991
    Date of Patent: September 7, 1993
    Assignee: NC Development, Inc.
    Inventor: Howard B. Dawson
  • Patent number: 5229105
    Abstract: A skin preparation offering protection against a variety of irritants (including allergens) is prepared from an oil-in-water emulsion of the cationic type, with a fatty acid mono-ester or di-ester of triethanolamine, or a fatty acid amide of hydroxyethyl-ethylenediamine, as the cation and active barrier ingredient. The resulting emulsion binds strongly to the skin through electrostatic bonding and forms an invisible yet effective barrier that isolates the skin from adversely charged irritants, small organic compounds, irritants of high molecular weight, and irritants of alkaline pH. The skin preparation may incorporate additional active agents, such as sunscreens, antibiotics and other therapeutics, for application of these agents to the skin.
    Type: Grant
    Filed: April 6, 1992
    Date of Patent: July 20, 1993
    Assignee: Donald Basiliere
    Inventor: Hermann Wilmsmann
  • Patent number: 5217648
    Abstract: A process is provided wherein hemoglobin, a fragile material, is formulated into high hemoglobin content water-in-oil-in-water multiple emulsion while maintaining high yields and high oxygen exchange activity. A multiple emulsion of aqueous oxygen carrying material in oil in outer aqueous phase is suitable for provision of oxygen for oxygen transfer processes. A hemoglobin multiple emulsion in physiologically compatible oil in an outer aqueous saline solution is provided in sufficiently small droplet size to provide oxygen flow through blood vessels to desired body tissues or organs thereby providing a blood substitute.
    Type: Grant
    Filed: October 11, 1991
    Date of Patent: June 8, 1993
    Assignees: Illinois Institute of Technology, Northfield Laboratories, Inc.
    Inventors: Richard L. Beissinger, Darsh T. Wasan, Lakshman R. Sehgal, Arthur L. Rosen
  • Patent number: 5208012
    Abstract: An anti-inflammatory cosmetic composition having a large effect of absorbing and shielding all of UV-A, UV-B and UV-C, small degeneration with the passage of time even upon absorption of light, small influence upon the skin, not lowered effect of absorbing light and high stability for heat is provided. This anti-inflammatory cosmetic composition comprises 0.1 to 20% by weight of a hydroxyaryl-s-triazine compound represented by the following structural formula in a cosmetically acceptable oil carrier: ##STR1## wherein R.sub.1 and R.sub.2 represent, same or different, hydrogen atoms, chlorine atoms, hydroxyl groups, alkoxy groups of 1 to 18 carbon atoms, aryloxy groups of 6 to 8 carbon atoms or mono- or dialkylamino groups containing 1 to 4 carbon atoms and R.sub.3 and R.sub.4 represent, same or different, hydrogen atoms, chlorine atoms, alkyl groups of 1 to 8 carbon atoms, methoxy groups or ethoxy groups.
    Type: Grant
    Filed: July 31, 1991
    Date of Patent: May 4, 1993
    Assignee: Daikyo Gomu Seiko Ltd.
    Inventors: Mirihiro Sudo, Tomoyasu Muraki, Eiji Kawachi, Yasushi Kawachi
  • Patent number: 5200401
    Abstract: Water-dispersible granules of compounds of the formula I ##STR1## in which A and B independently of one another are CH, CR.sub.4 and N,X is CH.sub.2, O, or S,Y is CH or N,Z is H or F,R.sub.1 and R.sub.4 independently of one another are H, halogen, (C.sub.1 -C.sub.3)-alkyl, (C.sub.1 -C.sub.3)-halogenoalkyl, (C.sub.1 -C.sub.3)-alkoxy, (C.sub.1 -C.sub.3)-halogenoalkoxy, (C.sub.1 -C.sub.4)-alkylthio, or (C.sub.1 -C.sub.4)-halogenoalkylthio, or R.sub.1 and R.sub.4 together are --CH.sub.2 --O--CH.sub.2 --;R.sub.2 is H, (C.sub.1 -C.sub.3)-alkyl, ethinyl, vinyl, halogen, cyano,R.sub.3 is H, halogen, (C.sub.1 -C.sub.4)-alkyl, (C.sub.1 -C.sub.3)-alkoxy andM is C or Si,which contain, in addition to finely divided highly absorptive silica and suitable wetting and dispersing agents, an aluminum silicate or magnesium aluminum silicate and a mono-, di- or trisaccharide, have a high spontaneous dispersibility, a very low wet-screening residue and very good storage-stability properties.
    Type: Grant
    Filed: February 15, 1991
    Date of Patent: April 6, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hans Rochling, Joachim Baumgartner
  • Patent number: 5198431
    Abstract: Concentrated aqueous emulsions of compounds of the formula I ##STR1## in which A and B independently of one another are CH, CR.sub.4 or N,X is CH.sub.2, O or S,Y is CH or N,Z is H or F,R.sub.1 and R.sub.4 independently of one another are H, halogen, (C.sub.1 -C.sub.3)-alkyl, (C.sub.1 -C.sub.3)-haloalkyl, (C.sub.1 -C.sub.3)-alkoxy, (C.sub.1 -C.sub.3)-haloalkoxy, (C.sub.1 -C.sub.3)-alkylthio or (C.sub.1 -C.sub.4)-haloalkylthio, or R.sub.1 and R.sub.4 together are --CH.sub.2 --O--CH.sub.2 --;R.sub.2 is H, (C.sub.1 -C.sub.3)-alkyl, ethynyl, vinyl, halogen or cyano,R.sub.3 is H, halogen, (C.sub.1 -C.sub.4)-alkyl or (C.sub.1 -C.sub.3)-alkoxy andM is C or Si, which contain a combination of an anionic emulsifier, an n-butanol/propylene oxide/ethylene oxide block oxalkylate and a sodium magnesium (and/or aluminum) silicate having a layered structure,have very good storage stability, good pourability and advantageous properties in use.
    Type: Grant
    Filed: February 15, 1991
    Date of Patent: March 30, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Hans Rochling
  • Patent number: 5196187
    Abstract: A water-pin-silicone oil emulsion, suitable for topical application to mammalian skin or hair, comprises, in addition to water, a volatile polydimethylsiloxane, a silicone surfactant ingredient comprising a polymer of dimethylpolysiloxane with polyoxyethylene and/or polyoxypropylene side chains having a molecular weight of from 10,000 to 50,000, a 2-hydroxyalkanoic acid or derivative thereof, ultrafine titanium dioxide, and an inorganic electrolyte.
    Type: Grant
    Filed: May 10, 1991
    Date of Patent: March 23, 1993
    Assignee: Chesebrough-Pond's USA Co., Division of Conopco, Inc.
    Inventors: Gregg A. Nicoll, Ann C. Ojo-Osagie, Mavis C. Pereira
  • Patent number: 5189066
    Abstract: The subject invention involves compositions, consisting essentially of the drug active 1-3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl-5-hexyn-1-one (tebufelone) at a concentration of at least about 15%, and the balance a pharmaceutically-acceptable vehicle. The vehicle is formulated such that the compositions are homogeneous liquids at 37.degree. C. and provide good solubilization of the drug active.
    Type: Grant
    Filed: July 19, 1991
    Date of Patent: February 23, 1993
    Assignee: The Procter & Gamble Company
    Inventors: Gary R. Kelm, Alan E. Bruns
  • Patent number: 5183589
    Abstract: Stable diphase emulsions consisting of:a) perfluoropolyethers having perfluoroalkyl end groups;b) a conventional surfactant,dispersed inc) a continuous dispersing phase consisting of glycerol or of a polyhydroxylated compound containing at least three hydroxyl groups, selected from polyalcohols and saccharides, dissolved in a hydrophile solvent and/or water.
    Type: Grant
    Filed: March 30, 1990
    Date of Patent: February 2, 1993
    Assignee: Ausimont S.r.l.
    Inventors: Fabio Brunetta, Giovanni Pantini
  • Patent number: 5181276
    Abstract: The present invention relates to infection resistant materials and or products made from a molten blend of at least one polymer and a compound having antioxidant, plasticizer and antiviral activity. Additionally, this compound has a hydrophilic lipophilic balance of between 12 and 20. The preferred polymer, polyvinyl chloride, is blended with the antioxidant, plasticizer, antiviral compound NONOXYNOL-9 (.alpha.-nonylphenyl-w-hydroxypoly(oxy-1, 2-ethanediyl) to form the infection resistant material.
    Type: Grant
    Filed: September 9, 1991
    Date of Patent: January 26, 1993
    Assignee: Baxter International Inc.
    Inventors: Jean Kersten, Yves A. Delmotte
  • Patent number: 5178871
    Abstract: A preferred method of producing an aqueous, stable double emulsion is disclosed. The first step of the method is the production of an "inner" emulsion. The inner emulsion is produced by combining water, a liquid hydrocarbon solvent, and an emulsifier, in an agitated mixing vessel, along with an effective amount of finely-divided particulate material, to produce an oil-in-water emulsion having a viscosity of no more than about 200,000 centipoises, wherein the finely-divided particulate material is substantially homogeneously-dispersed throughout the thus-produced oil-in-water emulsion. The second step of the method is the production of an "outer" emulsion. The outer emulsion is produced by combining a liquid hydrocarbon solvent, water, and an emulsifier, in an agitated mixing vessel, to produce a water-in-oil emulsion. The third step of the method is the production of a "dual" emulsion.
    Type: Grant
    Filed: June 26, 1991
    Date of Patent: January 12, 1993
    Assignee: S. C. Johnson & Son, Inc.
    Inventor: Francis L. Thill
  • Patent number: 5178795
    Abstract: A homogenous, essentially nonaqueous adjuvant composition comprising a spray oil and a surfactant blend of a sorbitan fatty acid ester, a polyethoxylated sorbitan fatty acid ester and an alkylaryl polyethoxy phosphate ester buffering agent is disclosed. When mixed with an herbicide or a pesticide, the composition provides one-step mixing of the adjuvants to obtain a more uniform spread of the spray solution, improved penetration and slower evaporation. The composition maintains the pH of the spray solution within a desired range even in the presence of alkaline waters typically used in spray solutions.
    Type: Grant
    Filed: July 19, 1990
    Date of Patent: January 12, 1993
    Assignee: Helena Chemical Company
    Inventor: Johnnie R. Roberts
  • Patent number: 5162377
    Abstract: A transparent composition containing a phospholipid, at least one cationic or nonionic surfactant, an oily component, and water.
    Type: Grant
    Filed: June 15, 1989
    Date of Patent: November 10, 1992
    Assignee: Shiseido Company, Ltd.
    Inventors: Hiroyuki Kakoki, Shoji Nishiyama, Michihiro Yamaguchi, Yoshimaru Kumano
  • Patent number: 5160734
    Abstract: Complex of 1,4-dihydropyridine with polyoxyethylene-polyoxypropylene copolymer useful in sustained release dosage formulations.
    Type: Grant
    Filed: January 15, 1991
    Date of Patent: November 3, 1992
    Assignee: American Cyanamid Company
    Inventors: Madurai G. Ganesan, Narendra R. Desai, Gary A. Maier, Prakash S. Kulkarni
  • Patent number: 5156833
    Abstract: A powder aerosol composition is disclosed which includes a powder, a liquefied propellant gas selected from liquefied petroleum gases and liquefied natural gases, and a nonionic surfactant which is substantially insoluble in the liquefied propellant gas.
    Type: Grant
    Filed: February 4, 1991
    Date of Patent: October 20, 1992
    Assignee: Lion Corporation
    Inventors: Takao Osugi, Toshihiro Jinno
  • Patent number: 5143940
    Abstract: Ambiphilic creams with improved spreading and penetration properties as well as improved tolerance contain a glycerol-monostearate-free water-in-oil emulsifier and glycerol and/or sorbitol. Ambiphilic creams with an isopropyl myristate content have particularly favorable properties.
    Type: Grant
    Filed: December 20, 1990
    Date of Patent: September 1, 1992
    Assignee: Stada Arzneimittel AG
    Inventors: Eberhard Nurnberg, Uwe Leonhardt, Otto P. Hornstein, Gabriele Griessmeyer, Harald Perschbacher
  • Patent number: 5143717
    Abstract: An antibiotic formulation useful in the treatment of burns and abrasions and adapted for topical application as a clinically water soluble foam, the process for preparing the formulation and a special dispenser system for applying same.
    Type: Grant
    Filed: August 2, 1989
    Date of Patent: September 1, 1992
    Assignee: Code Blue Medical Corporation
    Inventor: Richard C. Davis
  • Patent number: 5143722
    Abstract: Compositions comprising water-in-oil emulsions are disclosed comprising pigment coated with polysiloxane; a silicone phase; a water phase; and a polydiorganosiloxane-polyoxylalkylene copolymeric surfactant.
    Type: Grant
    Filed: June 12, 1991
    Date of Patent: September 1, 1992
    Assignee: Revlon, Inc.
    Inventors: Jane Hollenberg, Lou A. Lombardi, Marlene Tietjen
  • Patent number: 5116536
    Abstract: The invention relates to a process for the preparation of fine-particled, stable, pharmaceutical or cosmetic dispersions consisting of an aqueous phase and an organic phase which is insoluble or not completely soluble in water (oily phase), in which a pre-emulsion is first prepared from the two phases by known emulsifying methods and is then further processed to the end product. The invention furthermore relates to apparatus for carrying out the process.
    Type: Grant
    Filed: September 13, 1990
    Date of Patent: May 26, 1992
    Assignee: Bayer Aktiengesellschaft
    Inventors: Manfred Bucheler, Hans Gehringer, Bernd Klinksiek, Bernd Koglin
  • Patent number: 5114703
    Abstract: Injectable contrast agents of great clinical importance for lymphography, characterized by non-water soluble particle sizes between about 5 or 10 nm and about 500 or 900 nm, which have selective distribution to lymph nodes upon percutaneous administration and can be imaged with millimeter resolution. Also disclosed are methods for performing percutaneous lymphography using these contrast agents.
    Type: Grant
    Filed: May 29, 1990
    Date of Patent: May 19, 1992
    Assignee: Alliance Pharmaceutical Corp.
    Inventors: Gerald L. Wolf, David M. Long
  • Patent number: 5112620
    Abstract: A therapeutic ointment having wet adherent properties and particularly well suited for delivery of medicaments to mucosal surfaces includes a base material comprising from about 3 to 15% by weight of a water soluble salt of a copolymer of methyl vinyl ether and maleic acid or anhydride in a polyethylene glycol ointment. Formulations of the base material with triamcinolone acetonide and lidocaine are particularly efficacious in the treatment of recurrent aphthous ulcers.
    Type: Grant
    Filed: September 20, 1990
    Date of Patent: May 12, 1992
    Assignee: Mikkur, Inc.
    Inventors: Michael A. Repka, Thomas G. Gerding
  • Patent number: 5104656
    Abstract: To prepare an analgesic, anti-inflammatory cream, ibuprofen-S is dissolved in the PEG-7-glycerylcocoate and propylene glycol by slightly warming the solution to about 40 degrees Centigrade. Fractionated coconut oil, di-isopropyladipate, stearic acid, cetyl alcohol, polyoxyl-40-stearate, sorbitan-monostearate and propylparaben are mixed and heated to 70 degrees Centigrade. Methylparaben Sod. is dissolved in demineralized water and heated to 70 degrees Centigrade. The above oil and water phase components are mixed together, cooled to about 50 degrees Centigrade and the ibuprofen-S solution is added to the emulsion. The emulsion is homogenized and cooled to room temperature to form the cream.
    Type: Grant
    Filed: June 16, 1989
    Date of Patent: April 14, 1992
    Inventors: Pyare L. Seth, Lorne A. Campbell
  • Patent number: 5098694
    Abstract: A natural deodorant composition containing glyceryl laurate, sorbic or benzoic acid and citric acid.
    Type: Grant
    Filed: September 25, 1990
    Date of Patent: March 24, 1992
    Assignee: The Procter & Gamble Company
    Inventors: Bernd Komp, Christiane Gigengack
  • Patent number: 5091171
    Abstract: Preventive as well as therapeutic treatment to alleviate cosmetic conditions and symptoms of dermatologic disorders with amphoteric compositions containing alpha hydroxyacids, alpha ketoacids, related compounds or polymeric forms of hydroxyacids is disclosed. The cosmetic conditions and the dermatologic disorders in which the amphoteric compositions and the polymeric compounds may be useful include dry skin, dandruff, acne, keratoses, psoriasis, eczema, pruritus, age spots, lentigines, melasmas, wrinkles, warts, blemished skin, hyperpigmented skin, kyperkeratotic skin, inflammatory dermatoses, skin changes associated with aging, and skin requiring cleansers.
    Type: Grant
    Filed: August 15, 1989
    Date of Patent: February 25, 1992
    Inventors: Ruey J. Yu, Eugene J. Van Scott
  • Patent number: 5085854
    Abstract: A translucent cosmetic emulsion comprising the following components (a) to (d),(a) a monoalkyl phosphate represented by formula (I): ##STR1## wherein R represents a .beta.-branched alkyl group having from 8 to 36 carbon atoms; and X represents an alkali metal or an organic basic group; or a dialkyl phosphate represented by formula (II): ##STR2## wherein R.sub.1 and R.sub.2 each represent a hydrocarbon group having from 10 tgo 24 carbon atoms; and x is as defined above;(b) at least one nonionic surfactant, wherein the surfactant has an HLB value of from 7 to 20, and wherein when two or more nonionic surfactants are present, the surfactants together have an HLB value of from 7 to 20;(c ) an oily matrix; and(d) water;is disclosed. This translucent cosmetic emulsion is highly safe and remains stable upon prolonged storage.
    Type: Grant
    Filed: April 5, 1991
    Date of Patent: February 4, 1992
    Assignee: Kao Corporation
    Inventors: Morinobu Fukuda, Yoshitsugu Kamata, Masahiko Asahi
  • Patent number: 5085856
    Abstract: A cosmetic emulsion suitable for topical application to the lips comprises in addition to oil and water, an emulsifier system comprising:i) as a first emulsifier, a phospholipid, andii) a second emulsifier having a melting point of from -5.degree. C. to 80.degree. C.Preferred emulsions are lipsticks and lip gloss product which can additionally comprise wax.
    Type: Grant
    Filed: July 25, 1990
    Date of Patent: February 4, 1992
    Assignee: Elizabeth Arden Co., division of Conopco, Inc.
    Inventors: Patrick J. Dunphy, Alan J. Meyers, Richard T. Rigg
  • Patent number: 5082591
    Abstract: A surface active agent formed by a polyoxethylenated and polyoxypropylenated di and/or tri (1-phenyl ethyl) phenol with 16 to 35 statistically distributed recurrent oxyalkylenated units. The ratio between the number of recurrent oxyethylenated units and the number of recurrent oxypropylenated units ranges from 75/25 to 90/10. The surface active agent is prepared by means of the reaction of a di and/or tri (1-phenyl ethyl) phenol and a mixture of monoethylene glycol and monopropylene glycol with a monoethylene giycol/monopropyleneglycol molar ratio ranging from 75/25 to 90/10. The surface active agent can be used for producing concentrated emulsifiable solutions of active materials, in particular phytosanitary materials.
    Type: Grant
    Filed: May 30, 1989
    Date of Patent: January 21, 1992
    Assignee: Rhone-Poulenc Chimie
    Inventors: Antonio Marchetto, Anghelito Mascheroni, Georges Ruffo
  • Patent number: 5080885
    Abstract: A non-toxic, brominated perfluorocarbon emulsion for internal and intravenous use in animals (including humans) is disclosed, for use as an oxygen transport medium and as a contrast enhancement medium capable of facilitating the detection of tumors and other elements within the body. This emulsion is stable and maintains its very small particle size characteristics for extended periods of time, often exceeding eighteen months after sterilization, and further may include a stabilizing component selected from the group consisting of steroids, tocopherols, cholesterols, and combinations thereof. An anti-oxidizing component enhances delivery in oxygen transport.
    Type: Grant
    Filed: August 24, 1989
    Date of Patent: January 14, 1992
    Assignee: Alliance Pharmaceutical Corp.
    Inventor: David M. Long, Jr.
  • Patent number: 5077036
    Abstract: Biocompatible fluorcarbon emulsions having fluorocarbon in concentrations of from 75% weight per volume to 125% weight per volume have small, biocompatible particle size stability through heat sterilization with one emulsifying agent, including phospholipids, in concentrations of from 3% to 7% weight per volume. The single emulsifying agent can be hydrogenated lecithins and synthesized lecithins. Fluorocarbon emulsions having fluorocarbon in concentrations of from 40% weight per volume to 125% weight per volume have stability of partial pressure of oxygen and of partial pressure of carbon dioxide through heat sterilization and storage for extended periods of time after having been oxygenated with dissolved oxygen.
    Type: Grant
    Filed: March 30, 1990
    Date of Patent: December 31, 1991
    Assignee: Alliance Pharmaceutical Corp.
    Inventor: David M. Long, Jr.
  • Patent number: 5066485
    Abstract: Compositions comprising oil-in-water emulsions are disclosed comprising pigment coated with polysiloxane; a silicone phase; a water phase; and a polydiorganosiloxane-polyoxyalkylene copolymeric surfactant.
    Type: Grant
    Filed: September 5, 1990
    Date of Patent: November 19, 1991
    Assignee: Revlon, Inc.
    Inventors: Hernando Brieva, Natividad Jose, Marlene Tietjen
  • Patent number: 5061688
    Abstract: A multiple emulsion of aqueous oxygen carrying material in oil in outer aqueous phase is suitable for provision of oxygen for oxygen transfer processes. A hemoglobin multiple emulsion in physiologically compatible oil in an outer aqueous saline solution is provided in sufficiently small droplet size to provide oxygen flow through blood vessels to desired body tissues or organs thereby providing a blood substitute. A process is provided wherein hemoglobin, a fragile material, is formulated into high hemoglobin content water-in-oil-in-water multiple emulsions while maintaining high yields and high oxygen exchange activity.
    Type: Grant
    Filed: August 19, 1988
    Date of Patent: October 29, 1991
    Assignees: Illinois Institute of Technology, Northfield Laboratories, Inc.
    Inventors: Richard L. Beissinger, Darsh T. Wasan, Lahksman R. Sehgal, Arthur L. Rosen
  • Patent number: 5039516
    Abstract: A water resistant, non-gummy, hygroscopic, flexible and pliable thin film containing a combination of a sunscreening agent and a 2-hydroxyethyl methacrylate homopolymer deposited on an epidermal surface, a stable emulsion from which the film can be made and a special process for the manufacture of the stable emulsion. The topical application of stable emulsions from which a water resistant, non-gummy, hygroscopic, flexible and pliable thin film of 2-hydroxyethyl methacrylate homopolymer in combination with a sunscreening agent is deposited on an epidermal surface. Special solvent combinations and emulsification techniques are described.
    Type: Grant
    Filed: August 24, 1988
    Date of Patent: August 13, 1991
    Assignee: Dento-Med Industries, Inc.
    Inventors: Jack J. Goodman, Harvey S. Tauman, Charles Fox, Thomas J. Hart
  • Patent number: 5036108
    Abstract: A water-in-oil type emulsion cosmetic, which comprises a specific emulsifier mixture, an oily base containing a silicone oil and water and has a viscosity of 20,000 cps or below at 25.degree. C. is disclosed. The water-in-oil type emulsion cosmetic of the present invention imparts a good feel to the skin during use, is safe to use and has a high storage stability, which makes it widely applicable for use in, for example, milky lotions, body-care lotions and liquid-type foundations.
    Type: Grant
    Filed: December 13, 1989
    Date of Patent: July 30, 1991
    Assignee: Kao Corporation
    Inventors: Masahiko Asahi, Noriko Shirakawa, Yuko Kikuta
  • Patent number: 5028623
    Abstract: The insecticidal transparent emulsion of the present invention is obtained by mixing (A) at least one pyrethroidal insecticide as defined in the claims as an active ingredient; (B) a polar solvent containing mixed surface active agent containing at least one metal alkylbenzenesulfonate, at least one nonionic surface active agent having an HLB (hydro- and lipophilicity balance) of 10 to 18 and at least one polar solvent; and (C) water, so that the content of (B) in the mixture is equal to or more than that of (A) and 6% by weight or less and then diluting the resulting mixture. The insecticidal transparent emulsion of the present invention has the advantage that the solution state is unchanged even when the environmental temperature sharply moves up and down.
    Type: Grant
    Filed: July 24, 1989
    Date of Patent: July 2, 1991
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Tadahiro Matsunaga, Kazunobu Dohara
  • Patent number: 5015469
    Abstract: A water-in-oil type emulsified composition containing a water-swellable clay mineral, a nonionic surfactant, an oil component, and water as the essential constituents or containing a water-swellable clay mineral, a quaternary ammonium salt type cationic surfactant, one or two more kinds of polyoxyalkylene modified organopolysiloxane, an aqueous phase, and an oil phase containing one or two or more kinds of organic silicone resin comprising the units of the formula:RnSiO.sub.(4-n)/2wherein R is a hydrocarbon group having 1 to 6 carbon atoms or a phenyl group, and n represents a value of 1.0 to 1.8, and a water- and polyhydric alcohol-in-oil type emulsified composition containing an oil phase containing a polyoxyalkylene modified organopolysiloxane, a water-swellable clay mineral, a quaternary ammonium salt type cationic surfactant and a silicone oil, water, and a polyhydric alcohol.
    Type: Grant
    Filed: July 23, 1990
    Date of Patent: May 14, 1991
    Assignee: Shideido Company Ltd.
    Inventors: Toshio Yoneyama, Michihiro Yamaguchi, Shinji Tobe, Tomiyuki Nanba, Masaaki Ishiwatari, Hidekazu Toyoda, Shin Nakamura, Yoshimaru Kumano, Sadaki Takata, Hiromi Ito
  • Patent number: 5002952
    Abstract: A pharmaceutical composition comprising a benzoyl urea compound having the formula: ##STR1## wherein X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z.sub.1 is a halogen atom or a trifluoromethyl group, Z.sub.2 is a hydrogen atom or a halogen atom, and A is a .dbd.CH--group or a nitrogen atom, and a nonionic surfactant.
    Type: Grant
    Filed: July 27, 1989
    Date of Patent: March 26, 1991
    Assignees: Ishihara Sangyo Kaisha Ltd., The Green Cross Corporation
    Inventors: Nobuo Kondo, Tsunetaka Nakajima, Masahiro Watanabe, Kazumasa Yokoyama, Takahiro Haga, Nobutoshi Yamada, Hideo Sugi, Toru Koyanagi
  • Patent number: 5002974
    Abstract: A long lasting, esthetically pleasing medicated skin care moisturizing composition comprising(1) an oil phase comprising oil from about 30% to about 80% and a non-ionic surface active agent having an HLB number of about 7 to about 12, wherein the non-ionic surface active agent is present in an amount of about 5% to about 9%;(2) an aqueous phase comprising an aqueous thickening agent from about 0.05% to about 5% and water from about 15% to about 65%;(3) an effective amount of a topical medicament; wherein the oil phase is added to the aqueous phase to form an emulsion and a topical medicament admixed into the emulsion has been developed.The method of preparation of the composition and a method of treating skin with the composition are also disclosed.
    Type: Grant
    Filed: April 4, 1988
    Date of Patent: March 26, 1991
    Assignee: Warner-Lambert Co.
    Inventor: Navin M. Geria
  • Patent number: 4996004
    Abstract: The invention relates to a process for the preparation of fine-particled, stable, pharmaceutical or cosmetic dispersions consisting of an aqueous phase and an organic phase which is insoluble or not completely soluble in water (oily phase) in which a pre-emulsion is prepared from the two phases by known emulsifying methods and in then pumped through a jet disperser, the temperature, the proportion of the aqueous and organic phases, and the pressure at the jet disperser being adjusted so that phase inversion of the emulsion is effected in the jet disperser at the same time as homogenization and fine dispersion, and in the course of which all the pressure energy is consumed in the dispersing zone and the dispersion leaves as a non-directional stream.
    Type: Grant
    Filed: March 15, 1989
    Date of Patent: February 26, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventors: Manfred Bucheler, Hans Gehringer, Bernd Klinksiek, Bernd Koglin