Abstract: Novel organopolysiloxane compositions that are storage-stable in the absence of moisture, but curable into elastomeric state in the presence of moisture, nonetheless devoid of any organometallic curing catalyst, include (A) an .alpha.,.omega.-dihydroxydiorganopolysiloxane oil, (B) a ketiminoxysilane crosslinking agent, (C) inorganic filler material, (D) an organofunctional silane and (E) a substituted hydroxylamine; the crosslinked elastomers produced from these organopolysiloxane compositions are well adopted for such applications as foodstuff packaging, medical bandaging and antifouling/anti-soiled coatings.

Abstract: Combinations of alkyl siloxy siloxane-containing polymers admixed with liquid polydimethylsiloxanes are excellent non-stinging, non-irritating liquid coating material for forming films which act as conformable bandages adhering to and protecting nails, skin and mucous membrane wounds from abrasion, contamination, and desiccation, while stopping pain from exposed nerve ends and allowing body fluid evaporation.

Abstract: A coating material for medical care having anti-bacterial action against Psuedomonas aeruginosa, Staphylococcus aureus, Escherichia coli and fungus is disclosed.Powdered zeolite, wherein one or the whole of metals contained in said zeolite is substituted by at least one kind of ion exchangeable metal selected from the group consisting of Ag, Cu and Zn, is coated onto the coating material made of silicone rubber etc or kneaded thereinto.

Abstract: Polyester-based hot-melt moisture indicator material for disposable articles containing a polyester, a carboxylic acid and an acid-base indicator.

Abstract: A surgical drape is disclosed. The drape comprises a synthetic polymeric film or fabric having incorporated therethrough an amount of an antimicrobial agent. The drape may optionally have an adhesive layer attached to one of its external surfaces wherein the adhesive layer has dispersed therethrough an antimicrobial agent. The preferred antimicrobial agent used is 5-chloro-2-(2,4-dichlorophenoxy)phenol.

Abstract: Polyester-based hot-melt moisture indicator material for disposable articles containing a polyester, a carboxylic acid and an acid-base indicator.

Abstract: A new series of copolymers which are useful as coatings for solid dosage forms, for transdermal devices, for wound dressing materials, and for contact lenses. Also disclosed are methods for preparing monomers and polymers as well as pharmaceutical compositions containing such polymers.

Abstract: A novel polymeric pressure-sensitive adhesive formulation is provided comprised of a hydrophilic base polymer compounded with at least one water-soluble tackifying component. Upon contact of the pressure-sensitive adhesive with excess amounts of water, the water-soluble tackifying component is caused to separate from the base polymer, thus decreasing the ability of the base polymer to function as a pressure-sensitive adhesive. The adhesive may subsequently be easily removed from any substrate to which it has been applied.

Abstract: The invention disclosed is a hydrogel-forming wound dressing or skin coating material suitable for household and veterinary use, consisting substantially entirely of wound-compatible and skin-compatible ingredients and comprising a first hydrophilic polymer, selected from polymers or copolymers of acrylic acid, polymers or copolymers of methacrylic acid, polymers or copolymers of itaconic acid, polymers or copolymers of maleic acid and polymers or copolymers of 3-butene-1,2,3-tricarboxylic acid, or combinations thereof, a second hydrophilic polymer which is capable of interacting with the first polymer to produce, upon drying, a hydrogel of improved water resistance and film forming properties relative to the first polymer alone and water. This material is film forming and substantially transparent but capable of being made opaque.

Abstract: A method is disclosed for treating a wound or attaching a device or article to the skin using a film of pressure sensitive adhesive having dispersed therein a discontinuous gaseous phase contained within voids in the adhesive. The adhesive is formed from the polymerization of a hydrophilic premix and exhibits high moisture vapor transmission and fluid absorbency.

Abstract: A water soluble dermal treatment film for dressing burns, surface wounds, cuts, scrapes, rashes or other dermal wound or lesion comprises a flexible sheet-like dressing made of polyalkyloxazoline. The dressing can have a structural layer and a pressure sensitive adhesive layer. The structural layer can be made of a polyalkyloxazoline composition formulated to obtain a flexible structural sheet. The pressure sensitive adhesive layer can be formulated to obtain pressure sensitive properties, maintaining the treatment film in position during its use. At such time the treatment film is to be removed, it can be removed without harsh scrubbing methods with a warm aqueous spray or soak. The sheet-like treatment means can be reinforced or impregnated with medicinal compositions to induce healing, reduce infection or stabilize the skin surface.

Abstract: Improvement in healing of wounds of the corneal stroma is obtained by placing into the wounds a corneal mortar composition comprising an extracellular matrix material and an ophthalmologically compatible carrier material, the composition having a sufficiently high viscosity to retain it within the wound under wound-healing conditions.

Abstract: This invention relates to a biodegradable collagen matrix having a pore size and morphology which enhances the healing of a wound. It further relates to a process for preparing the matrix. One embodiment of the invention comprises a biodegradable matrix which comprises collagen, hyaluronic acid and fibronectin. Other embodiments include a process which comprises freeze drying a dispersion containing collagen, crosslinking the collagen via two crosslinking steps and freeze drying the crosslinked matrix.

Abstract: Hydrocolloid adhesive compositions are disclosed comprising a rubbery elastomeric base having dispersed therein hydrocolloid particles, at least some of which are polycationic hydrocolloid particles. The compositions have enhanced resistance to breakdown by body fluids and are especially useful as wound dressings.

Abstract: A method of manufacturing a cohesive bandage comprising the steps of providing at least one layer of woven fabric and applying a coating containing polybutylacrylate ester and alkylphenyl polyethylene glycol to at least one fabric face is disclosed. In one embodiment, the coating is applied by an airless method, microselectively in statistical distribution where the quantity of coating is controlled by pump pressure. Alternatively, an aqueous dispersion of polybutyl acrylate ester and carboxymethyl cellulose is microselectively and cohesively coated on both sides of the fabric by screen printing to produce a regular dot pattern on both faces of the fabric.

Abstract: A transparent gel composition is provided for dressing of skin wounds. The dressing is in the form of a sheet comprising dextrin and a water-swellable, cross-linked polymer selected from polyacrylamide or polymethacrylamide. The ratio of dextrin to polymer ranges from about 2:1 to 1:1.

Abstract: The invention disclosed is a hydrogel-forming wound dressing or skin coating material suitable for household and veterinary use, consisting substantially entirely of wound-compatible and skin-compatible ingredients and comprising a first hydrophilic polymer, selected from polymers or copolymers of acrylic acid, polymers or copolymers of methacrylic acid, polymers or copolymers of itaconic acid, polymers or copolymers of maleic acid and polymers or copolymers of 3-butene-1,2,3-tricarboxylic acid, or combinations thereof, a second hydrophilic polymer which is capable of interacting with the first polymer to produce, upon drying, a hydrogen of improved water resistance and film forming properties relative to the first polymer alone and water. This material is film forming and substantially transparent but capable of being made opaque.

Abstract: This invention relates to medical devices formed totally or in part from homopolymers or copolymers comprising recurring carbonate moieties.

Abstract: This invention relates to novel copolymers containing carbonate repeat units and ester repeat units.

Abstract: An acrylic copolymer of ethyl acrylate and methacrylic acid wherein the weight ratio of ethyl acrylate to methacrylic acid is in a range between 75:25 and 95:5, containing therein a residual monomer content of 50 ppm or less, but substantially no surfactants, and which is useful as agents for protecting the skin and manufactured from the following essential components:a. an acrylic copolymer of ethyl acrylate and methacrylic acid wherein the weight ratio of ethyl acrylate to methacrylic acid is in a range between 75:25 and 95:5, containing therein residual monomers in an amount of 50 ppm or less, but substantially no surfactants--approximately 2 to 10%;b. cellulose derivative--approximately 0.2 to 2%; andc. a necessary amount of an aqueous alcohol to make the whole 100%.

Abstract: The perforations in a film-faced wound dressing have been discovered to have edges which, though clearly defined, lack the ability to cut the neoepithelium of a healing wound, with the result that the film affords an unexpectedly high degree of comfort during movement of the patient- and most particularly, when the dressing is changed. This occurs in a thin, soft, self-supporting elastomeric film, such as a polyether polyurethane (PPU) film, having less than 10% crystallinity. The film provides a degree of conformability not attained heretofore; has a softness and elastomeric quality which results in reduced shear associated with the edges of its perforations as compared with the sharp cutting edges of perforations in plastic film; has excellent releaase characteristics enhanced by less than 25% open area (due to perforations) which minimizes the open area into which the neoepithelium may grow.

Abstract: Adhesive compositions useful for use with medical devices, such as adhesive tapes, consist essentially of a homogeneous mixture of one or more polyisobutylenes or blends of one or more polyisobutylenes; a tackifying resin; a styrene copolymer; mineral oil; a water insoluble, water swellable, synthetic hydrocolloid which forms a gel when wet; and, an ethylene vinyl acetate copolymer which increases the dimensional stability of the final composition.

Abstract: A crosslinkable anionic binder composition which comprises an emulsion copolymer containing acrylamidoglycolic acid (AGA) and a zirconium III salt of an alpha or beta hydroxycarboxylic acid, the pH of the composition being from about 1.5 to 4.5. Provided are nonwoven binder compositions which are stable for extended periods prior to application of the binder composition onto the nonwoven substrate and initiation of crosslinking by application of heat.

Abstract: An improved bandage comprises a backing sheet constructed of a semi-interpenetrating polymer network. Use of a semi-interpenetrating polymer network allows for an extremely desirable combination of gas permeability and hydrostatic resistance. This construction of backing sheet provides for suitable vapor permeability and sufficient water impermeability because the pores therein are of a colloidal size range and the surface tension thereof results in the backing material being hydrophobic.

Abstract: Metabolically-acceptable, surgical adhesives are prepared from polyisocyanates having the structral formula: ##STR1## wherein R is a polyvalent aliphatic radical of about 1 to 10 carbon atoms or a polyvalent aromatic radical of 6 to about 24 carbon atoms;A is C, S or P;Z is O or S;Y is 1 when A is C or P, and 2 when A is S;n is 1 or 2;p is at least 1;q is 0 or 1, with the proviso that when A is carbon or sulfur, q is 0;r is 0 or 1, with the proviso that when A is carbon or sulfur, r is 0;X is a residue of an organic compound having active hydrogen-containing groups; andX' is a residue of an organic compound having at least 1 active hydrogen-containing group.

Abstract: The specification is directed to making noncellular dressings such as gelatinous wound dressings. According to the invention medical and surgical dressings are made by use of packages which may be held in the hand, and which contain the components of two part curable polysiloxane compositions in such a manner that the component may be mixed in predetermined proportions and dispensed therefrom under the influence of propellant gas. The method avoids the need for manual mixing of such compositions during production of dressings.

Abstract: Latex compositions suitable for applications requiring surface hydrophilicity are disclosed. The compositions comprise: (1) a liquid phase selected from the group consisting of water, water-miscible solvents and mixtures thereof; and (2) latex particles dispersed in the liquid phase. The particles comprise an elastomeric hydrophobic core and a hydrophilic "shell" which is integral with the core and which colloidally stabilizes the latex particles in the liquid phase. The shell comprises moieties L-Q attached to the core, wherein Q is a nonionic group end-capped with a cationic moiety, and L is a linking unit. When the liquid phase is removed, the particles are capable of forming an elastomeric film having a substantially permanent, cationic, hydrophilic surface. The cationic moiety helps the latex particles become attracted to anionic surfaces such as cellulosic materials.

Abstract: A synthetic resin matrix system for the delayed and extended duration delivery of drugs to humans and animals is disclosed consisting of a polymer, such as poly(2-hydroxyethylmethacrylate), referred to as PHEMA, an organic solvent, such as polyethylene glycol (PEG), and a hydrogen binding plasticizer, such as dimethylsulfoxide (DMSO). The plasticizer regulates the set-up time of the synthetic resin so that the more plasticizer present, the shorter the set-up time. The plasticizer also has a direct shortening effect upon the cure time and also profoundly influences many of the physical characteristics of the resultant synthetic resin matrix system. A variety of drugs can be embodied in the fabricated matrix system and administered to the patient (or animal) by different modes of application, including but not limited to oral, topical, rectal, subcutaneous implant, or organ-specific implant such as in the conjunctival sac of the eye.

Abstract: A wetness indicating hot-melt adhesive which changes color in response to the presence of moisture is disclosed, which contains 20 to 70 wt. % of polymer, about 28 to 10 wt. % of which is water sensitive polymer; 25 to 60% of organic acid which is selected from a high acid fatty acid, or rosin acid, or a combination thereof; 0 to 40% of water soluble wax; 0 to 60 wt. % of glycerlo monostearate; 0 to 55 wt. % of hydrogenated castor oil; 0 to 15 wt. % of polyalkylene wax; 0 to 60 wt. % of compatible plasticizer; and a wetness indicating agent which changes the color of the composition in response to moisture therein. The time of response of the color change can be controlled from about one second to a somewhat larger value as desired.

Abstract: Elastomeric or flexible surgical adhesives, comprising [A] NCO-terminated hydrophilic urethane prepolymer derived from hydrophilic polyether polyol of higher oxyethylene content, or combination of [A] with [B] unsaturated cyano compound containing cyano group attached to a carbon atom constituting the polymerizable double bond, are used for bonding of tissues, with rapid cure rate and sufficient bonding power.

Abstract: Surface-hydrophilic perforated sheets comprise a fluid-permeable hydrophobic sheet having a multiplicity of holes for fluid passage. The sheets are coated with a rubber-like material insoluble in aqueous fluid but having surface-hydrophilic properties, whereby the surface of the sheet is rendered hydrophilic. The sheets are particularly useful as cover sheets for absorbent structures such as diapers, bandages, and catamenials.

Abstract: Latex compositions suitable for applications requiring surface hydrophilicity are disclosed. The latexes can be used in liquid film-forming compositions which comprise: (1) a liquid phase such as water, water-miscible solvents and mixtures thereof; and (2) latex particles dispersed in the liquid phase. The particles comprise an elastomeric hydrophobic core with a hydrophilic "shell" which is integral with the core. When the liquid phase is removed, the particles are capable of forming an elastomeric film having a substantially permanent hydrophilic surface.

Abstract: A skin adhesive coated sheet material is provided which is coated with a polymer that exhibits an enhanced level of initial adhesion when applied to skin but resists objectionable adhesion build up over time. The skin adhesives are comprised of a macromer reinforced acrylate copolymer which has a creep compliance value at least about 1.2.times.10.sup.-5 cm.sup.2 /dyne. A stable chemical complex of iodine, iodide and a pressure-sensitive adhesive is also provided wherein the adhesive has a creep compliance value of at least about 1.0.times.10.sup.-5 cm.sup.2 /dyne measured when the adhesive composition is substantially free of iodine.

Abstract: Bio-and blood compatible materials are prepared by treating the surface of a substrate to provide reactive primary or secondary amine groups sites which are activated by treatment with a dialdehyde or arylchloride for coupling to a biological in an amount sufficient to provide compatibility. The use of specific substrates, such as a compliant, and elastic material, such as a fabric-elastomer membrane matrix, results in a product having advantageous qualities as a thermal burn dressing. Detailed procedures and various products are described including gloves and sleeves and tubes with or without adhesive to facilitate formation of sheet materials into various forms and products. The products may have small holes provided therein for the rapid passage of accumulated fluid away from the wound or infusion of liquid materials to the wound site.

Abstract: A synthetic resin matrix dressing is disclosed consisting essentially of a polymer, such as poly(2-hydroxyethylmethacrylate), referred to as PHEMA, an organic solvent, such as polyethylene glycol (PEG), and a hydrogen bonding plasticizer, such as dimethylsulfoxide (DMSO). The plasticizer regulates the set-up time of the synthetic resin so that the more plasticizer present, the shorter the set-up time. The dressing may be applied to the treatment site in veterninary use in the form of a paste for the in-situ curing or setting thereof, or the dressing may be preformed and then applied to the treatment site. A variety of drug agents may be incorporated in the synthetic resin matrix so as to result in the time released administration of the drug agent to the area of the skin covered by the dressing. A method of treatment using this dressing is also disclosed.

Abstract: Disclosed herein is a urine absorbing and holding material, which comprises a homopolymer of at least one monomer selected from specific N-alkyl- or N-alkylene-substituted acrylamides and methacrylamides, a copolymer of two or more of the acrylamides and methacrylamides, a copolymer of said at least one monomer with one or more monomers other the the acrylamides and methacrylamides and copolymerizable therewith, and being a water-insolubilized product. By combining the urine absorbing and holding material in the form of powder, granules, flakes, fibers or a film with a fibrous material in the form of a woven fabric, non-woven fabric or a flocculent material, a useful urea absorbing and holding composite material is obtained in the form of a pad, diaper or drawers.

Abstract: The present invention relates to a method for treating an injured part on the oral mucosa, which comprises covering the injured part with a covering material consisting essentially of a cellulose lower alkyl ether and a polyacrylic acid or its pharmaceutically acceptable salt, and to said covering material.According to the present invention, without using a medicament, the injured part on an oral mucosa can be cured rather rapidly simply by covering the injured part.

Abstract: New catalysts useful in the curing of a water-curable isocyanate-functional prepolymer are provided. The new catalyst is a new 2,2'-dimorpholinyldialkyl ether. The use of the improved catalyst provides prepolymer/catalyst premix compositions having equivalent or increased shelf stability and which, when water-cured, yield resins having superior early strengths. A method of curing an isocyanate-functional prepolymer and articles useful as orthopedic bandages are also provided.

Abstract: There are disclosed processes for preparing biodegradable collagen-based matrices in sponge or sheet form wherein in one embodiment a collagen-based material including a collagen selected from the group consisting of types I, II and II collagens is freeze dried to form a collagen-based sponge which is contacted with a cross-linking agent selected from the group consisting of a carbodiimide or a succinimidyl active ester to form an intermediate collagen-based matrix which is subsequently subjected to conditions of severe dehydration to form the collagen-based matrix in sponge or sheet form. In another embodiment, a collagen-based sponge or sheet is first subjected to conditions of severe dehydration followed by contacting the thus formed intermediate collagen-based matrix with a carbodiimide crosslinking compound to form the collagen-based matrix in sponge or sheet form.

Abstract: A skin adhesive coated sheet material is provided which is coated with a polymer that exhibits an enhanced level of initial adhesion when applied to skin but resists objectionable adhesion build up over time. The skin adhesives are comprised of a macromer reinforced acrylate copolymer which has a creep compliance value at least about 1.2.times.10.sup.-5 cm.sup.2 /dyne.

Abstract: An elastomeric foam composition is useful in dentistry for separating the gingiva from the adjacent teeth, for cleaning, as a pressure pack and wound dressing and as a cushion between dental appliances and the gums of a dental patient. The composition is made from a paste-like system of components which expands at least about 150% to produce a uniformly fine-grained foam composition having a resistance to compression such that a force of at least about 50 g per square cm. is required to result in 10% deflection. In a preferred embodiment, the elastomeric foam composition is formed from a system of components which includes silicone fluids, siliceous fillers, crosslinkers, hydrogen, sources and a catalyst, all present in amounts which provide a paste-like consistency before foaming and a resistance to compression after foaming such that 80 g. per square cm. is required to produce a 10% deflection.

Abstract: The present disclosure is concerned with self-adhesive sheet-like structures made by adhering an adhesive polyurethane gel material to a supporting substrate and the utilization of such structures in the medical field to adhere materials such as plasters, wound dressings and appliances to the human body, and in other fields to connect articles, such as the parts of a fractured or cracked object, to one another by means of an adhesive bond. The gel is formed by immobilizing a high molecular weight polymeric polyol in the matrix of a covalently crosslinked polyurethane which is prepared by reacting polyisocyanates having an isocyanate functionality of at least 2 with higher molecular weight polyhydroxyl compounds having a hydroxyl functionality of at least 3. These reactants are selected in accordance with the following formula which relates the isocyanate number, K, (isocyanate to hydroxyl equivalents ratio times 100) to the average functionalities of the polyisocyanates (F.sub.

Abstract: An orthopaedic bandage is described which comprises a support carrying a vinyl compound, which compound polymerizes when exposed to a water-activated vinyl polymerization catalyst. The vinyl compound is a hydrophilic prepolymer which contains more than one polymerizable vinyl group. This prepolymer is in association with at least one component of a water-activatable vinyl polymerization redox catalyst in solid form in a water pervious coating which is insoluble in the prepolymer. Encapsulation of one component of the catalyst system in a water pervious coating provides a storage stable bandage which is activated by immersion in water and gives a satisfactory working time for immobilizing a limb compared to use of an uncoated catalyst.

Abstract: This invention relates to terpolymers which are capable of forming hydrogels having very good compatibility with living tissues and may be used as substitutes for damaged tissues, as in the form of implants and various prostheses. The terpolymers are comprised of an oligourethane having an average molecular weight from 1200 to 3000, 2-hydroxyethyl(meth)acrylate or 2-hydroxypropyl(meth)acrylate, and N-vinylpyrrolidone.

Abstract: A new breathable, conformable, polymeric adhesive composition is disclosed which comprises a self-sustaining pressure sensitive adhesive material and a hydrophilic filler, wherein the adhesive material forms a polymeric matrix characterized by the physical encapsulation of the hydrophilic filler within the matrix.

Abstract: A bacteria adsorbing composition which includes a first component comprising a powerfully hydrophobic, bacteria adsorbing, physiologically innocuous, preferably water-insoluble material, and a second component comprising a hydrophilic, liquid absorbing, physiologically innocuous material.

Abstract: A process of making a wound dressing is suggested, in which a technical conventional viscose solution is mixed with a polysaccharide derivative; the mixture is treated at increased temperatures such that it is thermally coagulated; the coagulate is wetted with a polyalkylene glycol and dried, whereby a particulate structure of the wound dressing is produced.

Abstract: Novel, hydrophilic, skin-compatible, pressure sensitive, solid, adhesive gel hydrogel composition comprising 25 to 50 weight percent polyvinyl pyrolidone (PVP) preferably having a molecular weight in the range of about 100,000 to 600,000, 2 to 5 weight percent polyvinyl alcohol (PVA) preferably having a molecular weight in the range of about 150,000 to 300,000, about 5 to about 40 weight percent humectant, about 3 to about 50 weight percent water, about 0 to about 50 weight percent of an ionic species. In a preferred aspect, the composition of the invention is utilized in an iontophoresis device to provide a hydrophilic gel matrix from which a drug is iontophoretically delivered.

Abstract: A flexible continuous film is comprised of a physical admixture of a polypeptide, a plasticizer and a film-forming flexible polymer. When the film is moistened, the polypeptides exude therefrom.

Abstract: A hydrogel which comprises polymerized moieties derivable from (i) at least one polymerizable cyclic (thio)ether and (ii) at least one hydrophilic homo- or copolymer.