Abstract: Dental composite formulations containing an initiator and a multiacrylate compound are disclosed. The formulations lack methyl methacrylate, a volatile, irritating, and potentially hazardous material commonly found in dental formulations. The multiacrylate compound has at least three acrylate functionalities per molecule. The formulations cure to form a surface lacking an oxygen inhibition layer. The formulations can be used as dental sealants, dental coatings, and in fingernail/toenail repair applications.

Abstract: The present invention relates to pharmaceutical compositions containing a synergistic amount of at least one bone morphogenetic protein (BMP) and a synergistic amount of at least one pyrrolidone optionally in a pharmaceutically acceptable carrier, such as a biodegradable polymer. The present invention further relates to methods of treating orthopaedic and dental, including periodontal, diseases by simultaneously administering a synergistic amount of at least one bone morphogenetic protein (BMP) and a synergistic amount of at least one pyrrolidone optionally in a pharmaceutically acceptable carrier to patients in need of such treatment.

Abstract: The present invention relates to a resin composition comprising a resin and apatite, wherein referring to the particulate form of said apatite present in the resin composition thus obtained, the apatite is present in a particulate form having an average diameter or average thickness (d) of not greater than 100 nm and an average aspect ratio (L/D) of not smaller than 5 as defined by the ratio of the average length (L) to said average diameter or average thickness (d).

Abstract: A permanent, biocompatible material for soft tissue augmentation. The biocompatible material comprises a matrix of smooth, round, finely divided, substantially spherical particles of a biocompatible ceramic material, close to or in contact with each other, which provide a scaffold or lattice for autogenous, three dimensional, randomly oriented, non-scar soft tissue growth at the augmentation site. The augmentation material can be homogeneously suspended in a biocompatible, resorbable lubricious gel carrier comprising a polysaccharide. This serves to improve the delivery of the augmentation material by injection to the tissue site where augmentation is desired. The augmentation material is especially suitable for urethral sphincter augmentation, for treatment of incontinence, for filling soft tissue voids, for creating soft tissue blebs, for the treatment of unilateral vocal cord paralysis, and for mammary implants. It can be injected intradermally, subcutaneously or can be implanted.

Abstract: Two-component preparation on the basis of silane functionalized polyether derivatives, which cures into an elastomer product after the mixing of a base component containing silane functionalized polyether derivate with a catalyst component containing organic or inorganic acid, wherein the base component comprises an antiacid.

Abstract: A peptide has any one of the sequences SEQ ID NO.1 to SEQ ID NO.8, or has a sequence derived from any one of the sequences SEQ ID NO.1 to SEQ ID NO.8 by substitution, deletion or addition of one or several amino acids therein and having an osteogenetic activity.

Abstract: The present invention is directed to microdispersions and pharmaceutical compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the liquid polymer having a melting point less than about 40° C., as determined by differential scanning calorimetry, and a synthetic, bioabsorbable, biocompatible polymeric wax comprising the reaction product of a polybasic acid or derivative thereof, a fatty acid and a polyol, the polymeric wax having a melting point less than about 70° C., as determined by differential scanning calorimetry.

Abstract: The invention provides high strength dental polymeric dental products made from wax-like polymerizable dental material. These dental products have superior strength compared to products formed from prior wax-like polymerizable materials. Prior wax-like polymerizable materials do not form strong enough polymeric material for making dentures. High strength dentures are made by positioning artificial teeth in wax-like polymerizable dental material of the invention. This material is then shaped and polymerized to the form a denture base of high strength dental polymeric material. These dentures are completed without forming wax and without applying inorganic plaster to the artificial teeth.

Abstract: The invention relates to uses of glasses and glass-ceramics in dental and orthodontic applications.

Abstract: The present invention is directed to reinforced, biocompatible, biodegradable compositions suitable for use in implantable medical devices and medical devices made at least in part from such compositions, where the compositions include a biocompatible, biodegradable polymer; a biocompatible, biodegradable wax; and greater than about 30 weight percent of an inorganic filler material.

Abstract: A composite material is provided which, while having an unusually high filler content may be extruded from a dental syringe and remains easily adaptable in the dental cavity. When materials of the present invention are cured, dental restorations are provided which have unusually high surface hardness and yield strength, as well as a low volume shrinkage on curing. This is achieved by use of a mixture of filler particles with a specific size, size range, and size relationship. Such a combination of properties makes the material of the present invention particularly useful for restoring cavities in posterior teeth.

Abstract: Bioactive spinal implant materials having optimized radiopacity, stiffness, and bioactivity properties for formulation of shaped bodies capable of withstanding large dynamic, compressive loads are provided. The invention also provides methods of making the optimized implant materials.

Abstract: The invention relates to a plastically deformable implant for inserting into bodily orifices of the human or animal body. Implants of this type are used, for example, in ophthalmology, in particular, as vitreous body or lens replacements and in dentistry, for example, for filling extraction cavities in jaw-bones. Known implants, however, are not suitable for long-term use. The invention aims to provide a deformable plastic implant which also has a long-term application. This is achieved by the fact that the implant consists of a gel which is not sealed, containing fluorocarbon and which is directly introduced into the natural, or artificially created bodily orifice.

Abstract: One embodiment of the invention provides a dental cement composition which includes (a) an acid group-having polymerizable monomer, (b) a polyalkenoic acid, (c) an ion-leachable glass filler, (d) a polymerizable monomer not having an acid group, (e) water, (f) a peroxide, (g) a salt of an aromatic sulfinic acid, and (h) an aromatic secondary amine and/or an aromatic tertiary amine.

Abstract: An ionomer composite composition having improved and unique physical properties, includes a glass material containing at least one of divalent cations and multivalent cations; and at least one copolymer. The copolymer comprises: at least one hydrophilic monomer containing acid functional groups adapted to react with the at least one of divalent cations and multivalent cations to form ionic crosslinks among polymer chains, the hydrophilic monomer present in an amount sufficient to impart a desired degree of aqueous solubility to the copolymer, and at least one hydrophobic monomer present in an amount sufficient to impart a desired degree of structural stability to the composite composition when exposed to an aqueous environment.

Abstract: A process for producing a rigid reticulated article involves coating a reticulated substrate which has open, interconnected porosity with a first dispersion comprising a ceramic or metal powder to form a first coating thereon; drying the coated reticulated substrate; contacting the coated reticulated substrate with one or more additional dispersions in succession to form one or more additional coatings thereon; drying the additional coatings between the steps of contacting; heating the coated reticulated substrate to pyrolyze organic components; and sintering the coated reticulated substrate to form a reticulated article, wherein each dispersion has a viscosity less than that of all preceding dispersions. A rigid reticulated article includes inner, intermediate and outer sintered layers of material in which the inner and outer layers are of different composition and the intermediate layer is a composite of the inner and outer layers.

Abstract: The present invention provides a dental material that includes a hardenable resin system and a first initiator system capable of hardening the hardenable resin.

Abstract: The invention relates to a redox initiator system which allows dental formulations to be cured in acidic medium by way of a free-radical polymerization and which ensures a high level of adhesion of the polymerizing composition to the hard substances of the teeth, namely enamel and, in particular, dentine. The redox initiator system comprises the following constituents: (A) from 14.9 to 50% by weight of a barbituric acid or thiobarbituric acid and/or of a barbituric or thiobarbituric acid derivative, (B) from 30 to 75% by weight of a peroxodisulfate compound and/or peroxodiphosphate compound, (C) from 10 to 35% by weight of a sulfinic acid compound, and (D) from 0.1 to 5% by weight of a copper compound.

Abstract: The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature and is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing. A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The supplementary material is in intimate contact with the hydroxyapatite material in an amount effective to impart a selected characteristic to the composite.

Abstract: Dental material containing an amide of the general formula BXn in which B stands for a hydrocarbon radical with 1 to 5 carbon atoms, which can contain one or more of the groups O, S, NH, CO—NH, O—CO—NH and/or NH—CO—NH, and which is substituted n times with the group X, X stands for the group which is bound via the nitrogen atom or via C-2 to the radical B, the bond site not connected to B carrying a radical R2, R1 being hydrogen, an alkyl group with 1 to 20 carbon atoms or a phenyl radical, two or more radicals X being able to share a radical R1 and R1 also being able to be a constituent of the radical B, R2 being hydrogen, an alkyl group with 1 to 20 carbon atoms or a phenyl radical, and n being a number from 2 to 5.

Abstract: Dental resin cement materials having unique handling properties are provided that comprise a) filler, b) polymerizable resin, and c) a polymeric handling modifier that is dispersed in the polymerizable resin at 25° C. and that has a molecular weight of between about 500 and 100,000. Components a) b) and c) are present in an amount effective to achieve a Viscosity vs Shear Rate Curve that fits a power law model of F(x)=AxB. The correlation value of the material to this curve is greater than 0.85 for both the increasing and decreasing shear rate curves, and the value of B is less than about ?0.01. Resin cements are also provided that comprise acid functionality and water, but which do not comprise an acid reactive filler. Such cements may be self etching, thereby avoiding the need to carry out a separate acid etch step.

Abstract: The invention relates to compositions containing: (a) 14 to 55 wt.-% fillers, (b) 3 to 35 wt.-% of at least one mono- or polyethylenically unsaturated compound which is not a urethane (meth)acrylate, (c) 0.1 to 5 wt.-% of at least one initiator system which is capable of starting a radical reaction, (d) 1 to 40 wt.-% plasticizers, (e) 0 to 10 wt.-% auxiliaries such as dyes, pigments, stabilizers, solvents, rheological additives such as flow-improvers and/or retarders, and (f) 30 to 81.9 wt.-% of at least two urethane (meth)acrylates with different molecular weights, these being present in a molecular weight ratio of 1.5:1 to 50:1.

Abstract: A composition suitable for preparing a biodegradable implant, comprising a crosslinkable multifunctional prepolymer having at least two polymerizable end groups, the said composition having a viscosity such that it is deformable at a temperature of 0° to 60° C. into a three-dimensional shape and being crosslinkable within the said temperature range. The prepolymer comprises a hydrophilic region and/or the composition further comprises an effective amount of a mineral biologically-active component delivery system and/or a biocompatible degradable porosity-inducing component.

Abstract: A dental polymerizable and curable composition that can be used as a dental composite restorative featuring excellent handling property at the time of filling, a small contraction upon polymerization, a high bending strength, excellent surface smoothness and wear resistance, and a very good matching of color tone to the natural tooth after restored.

Abstract: Novel polymer compositions that are useful in the manufacture of medical implants, implants having osteogenic properties and methods of making said implants are disclosed. Polymer compositions comprise a base material including a polymer matrix of resorbable polymer(s) or copolymer(s), and N-methyl-2-pyrrolidone (NMP), wherein NMP is present in an amount imparting osteogenic properties for the composition.

Abstract: A dental composition comprising a silver-containing ceramic having antimicrobial and color stabilizing properties and methods for using the composition. The composition comprises a silver-containing glass powder or a silver-containing zeolite powder, at least one monomer having at least one ethylenically unsaturated group, and a polymerization initiator system. Other components, such as a filler, may also be included. The inventive composition possesses antimicrobial properties and exhibits excellent mechanical properties upon curing. Additionally, when the polymerization initiator is a two-part redox initiator system, the composition has improved color stability. The inventive composition can be used as a dental restorative composition, an endodontic composition, an orthodontic composition, and/or a prosthetic composition.

Abstract: The present invention concerns an antibiotic/antibiotics preparation for resorbable and non-resorbable implants for human and veterinary medicine, for the treatment of local microbial infections in hard and soft tissue.

Abstract: The invention is directed toward a malleable bone putty and a flowable pastel composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of partially demineralized lyophilized allograft bone material having a residual calcium content ranging from 4 to 8% dry weight. The bone powder has a particle size ranging from about 100 to about 800 microns and is mixed in a high molecular weight hydrogel carrier containing a sodium phosphate saline buffer, the hydrogel component of the carrier ranging from about 1.00 to 50% of the composition and having a molecular weight of about at least 700,000 Daltons. The composition has a pH between 6.8-7.4 contains about 25% to about 35% bone powder and can be additionally provided with BMP's.

Abstract: Tooth tissues include the pulp mesenchyme that forms the dentin and an epithelium that is responsible for enamel formation. Cells from these tissues were obtained from porcine third molars and were seeded onto a biodegradable scaffold composed of a polyglycolic acid—polylactic acid copolymer. Cell polymer constructs were then surgically implanted into the omentum of athymic nude rats so that the constructs would have a blood supply and these tissues were allowed to develop inside the rats. Infrequently, columnar epithelial cells were observed as a single layer on the outside of the dentin-like matrix similar to the actual arrangement of ameloblasts over dentin during early tooth development. Developing tooth tissues derived from such cell polymer constructs could eventually be surgically implanted into the gum of an edentulous recipient where the construct would receive a blood supply and develop to maturity, providing the recipient with a biological tooth replacement.

Abstract: A dental composite having high filler loading and low shrinkage thereby providing good strength and marginal integrity. Through the use of prepolymerized filler particles in combination with a structural filler and a nanofiller, the composite exhibits very low shrinkage and is useful in stress bearing restorations and in cosmetic restorations. The structural filler used is ground to a mean particle size of less than 0.5 ?m and the nanofiller has discrete particles of a mean particle size less than 100 nm to improve handling and mechanical characteristics. The prepolymerized filler particles also allow for less viscosity and better handling characteristics of the composite.

Abstract: Microspheres for controlled release of a bioactive agent are disclosed, and in particular, blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery. The microsphere includes poly(propylene fumarate), a polymeric material other than poly(propylene fumarate) (e.g., poly(lactic-co-glycolic acid)), and a bioactive agent. The bioactive agent is selected depending on the physiological effect desired. For example, in bone regeneration applications, the bioactive agent may be selected from osteoinductive agents, peptides, growth hormones, osteoconductive agents, cytokines and mixtures thereof. The bioactive agent is dispersed in the microsphere, the microsphere has a diameter in the range of 1 to 300 micrometers, the poly(propylene fumarate) and poly(lactic-co-glycolic acid) are distributed in the microsphere, and the microsphere releases the bioactive agent in a sustained manner after an initial burst release.

Abstract: A process for producing a dental prosthesis wherein an impression is taken of the patient's mouth, a working model is created, a base plate is applied to the working model, an insulating film is applied to the base plate, a tooth arrangement in wax is formed on the base plate, a framework of the teeth is then formed with an investment compound, the wax is then boiled out and replaced with a curable material which is subsequently hardened.

Abstract: A visible light photopolymerizable composition comprising a) an aryliodonium salt and b) a titanocene derivate. These compositions can be used together with an epoxide resin as a dental composition.

Abstract: A paste type dental glass ionomer cement composition in paste type using no polymerizable monomer, that is good in operationality with excellent inherent characteristics of glass ionomer cement maintained, is constituted with a first paste and a second paste, in which the first paste contains 30 to 70% by weight of a polymer of an ?-? unsaturated carboxylic acid and 30 to 70% by weight of water, and the second paste contains 50 to 85% by weight of fluoroaluminosilicate glass, 0.005 to 1% by weight of a water soluble thickening agent and the remaining percentage by weight of water, the mixing amount of the water soluble thickening agent being preferably 0.01 to 0.4% by weight.

Abstract: The invention refers to a dental composition kit which comprises a combination of (A) a one-pack primer composition containing (a) an acid group-having polymerizable monomer and (b) an aromatic secondary amine and/or an aromatic tertiary amine, and (B) a cement composition containing (c) a polyalkenoic acid, (d) an ion-leachable glass filler, (e) a polymerizable monomer, (f) water, (g) a peroxide and (h) a salt of an aromatic sulfinic acid. A dental composition kit of this invention is easy to handle, and the cured product of the compositions bonds well to teeth. The kit is useful in restoring decayed or injured teeth and in bonding prostheses to teeth.

Abstract: Methods and compositions are described that provide three dimensional porous matrices as structural templates for cells. The porous matrices of the present invention have desirable mechanical properties suitable to a variety of applications, including platforms for in vitro cell cultivation, implants for tissue and organ engineering, and materials suitable for chromatography and filtration.

Abstract: N-alkyl aziridine block copolymers of the general structure (1), wherein R1 represents H, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkinyl, C7-C15 aralkyl C7-C15 aralkyl, or C3-C12 cycloalkyl and these groups can be substituted with C1 or F partially, completely or in a mixed manner and/or may contain 0 to 5 heteroatoms selected from O, N, S; R2 represents a group selected from R1 and/or R4; R3 represents SiR13 or SiR12R4, wherein R4 represents a group of the general formula (2), wherein A represents an (n+1) radical saturated, unsaturated or aromatic, linear, branched or cyclic hydrocarbon group that may contain 0 to 5 heteroatoms selected from O, N, S and that comprises 1 to 18 carbon atoms; B is selected from O, S, NR1; D is selected from C(O)O, C(O)NR1, C(O), C(S)NR1, CH2; E represents a diradical saturated or unsaturated, linear, branched or cyclic hydrocarbon group that may contain 0 to 5 heteroatoms selected from O, N, S, and that comprises 0 to 18 carbon atoms; Q represents and ?, ?-radical polyether chai

Abstract: Disclosed are compositions and methods for augmenting bone formation by administering isolated human mesenchymal stem cells (hMSCs) with a ceramic material or matrix or by administering hMSCs; fresh, whole marrow; or combinations thereof in a resorbable biopolymer which supports their differentiation into the osteogenic lineage. Contemplated is the delivery of (i) isolated, culture-expanded, human mesenchymal stem cells; (ii) freshly aspirated bone marrow; or (iii) their combination in a carrier material or matrix.

Abstract: Polymer nanocomposite implants with nanofillers and additives are described. The nanofillers described can be any composition with the preferred composition being those composing barium, bismuth, cerium, dysprosium, europium, gadolinium, hafnium, indium, lanthanum, neodymium, niobium, praseodymium, strontium, tantalum, tin, tungsten, ytterbium, yttrium, zinc, and zirconium. The additives can be of any composition with the preferred form being inorganic nanopowders comprising aluminum, calcium, gallium, iron, lithium, magnesium, silicon, sodium, strontium, titanium. Such nanocomposites are particularly useful as materials for biological use in applications such as drug delivery, biomed devices, bone or dental implants.

Abstract: The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein.

Abstract: The invention relates to polymerizable dental compositions which contain (a) 10 to 98.999 wt.-% of at least one bi- or higher-functional ethylenically unsaturated monomer, (b) 0 to 88.999 wt.-% of at least one monofunctional ethylenically unsaturated monomer, (c) 0 to 5 wt.-% of an accelerator, (d) 0.001 to 5 wt.-% of a redox initiator system which can trigger the radical polymerisation and (e) 0 to 88.999 wt.-% fillers, thixotropic auxiliaries, retarders and other auxiliaries (f) 1 to 30 wt.-% of a customary plasticizer and are characterized in that the redox initiator system comprises (i) a barbituric acid derivative and/or a malonyl sulfamide and (ii) an organic peroxide, selected from the group of the mono- or multifunctional carboxylic acid peroxyesters, and the constituents (a) to (f) are present in two pastes spatially separated from each other.

Abstract: A photocurable dental restorative comprising (i) 100 parts by weight of a polymerizable monomer, (ii) 0.01 to 5 parts by weight of a photopolymerization initiator of acylphosphine oxide, and (iii) 200 to 1900 parts by weight of an inorganic filler, wherein the inorganic filler (iii) is a mixed filler of: (A) irregular-shaped inorganic particles having an average particle size of not smaller than 0.1 ?m but smaller than 1 ?m; (B) spherical inorganic particles having an average primary particle size of not smaller than 0.1 ?m but not larger than 5 ?m; and (C) fine inorganic particles having an average primary particle size of not larger than 0.1 ?m; which are so blended as to satisfy the following mass ratios {circle around (1)} to {circle around (3)}: {circle around (1)} mA/(mB+mC)=0.2 to 3 {circle around (2)} mB/(mB+mC)=0.5 to 0.99 {circle around (3)} mC/(mB+mC)=0.01 to 0.5 where mA, mB and mC are masses of the inorganic particles (A) to (C).

Abstract: Ready-to-use preshaped, prefabricated cured structural components are prepared in a variety of shapes and sizes to be used in the fabrication of dental appliances. Preferably the structural components are fabricated of a fiber-reinforced composite material or a particulate-filled composite material comprising fibers or particulate filler impregnated with a polymeric matrix. The polymeric matrix is partially or fully cured to the point of sufficient hardness to provide a ready-to-use structural component for use in the fabrication of dental appliances such as orthodontic retainers, bridges, space maintainers, tooth replacement appliances, splints, crowns, partial crowns, dentures, posts, teeth, jackets, inlays, onlays, facings, veneers, facets, implants, abutments, cylinders, and connectors.

Abstract: A dental composition comprising self-lubricating particles and formed into a dental tooth. The invention provides a dental tooth formed from a composition which includes polymeric matrix material and particles of ultrahigh molecular weight polyethylene having a particle size less than 500 microns, and a weight average molecular weight greater than 1,000,000 g/mole chemically bonded to the matrix material and the composition formed into an aesthetic dental tooth. The tooth has an outer face, and at least one of the particles is smeared over the outer face.

Abstract: The invention provides a sterile medical implant or medical implant part comprising ultrahigh molecular weight polyethylene that has a molecular weight of about 400,000 atomic mass units or more. The invention also provides methods for producing, using, and preparing a medical implant or medical implant part, which comprise contacting the medical implant or medical implant part with water, such that the weight of the ultrahigh molecular weight polyethylene is increased, and the wear performance of the medical implant or medical implant part desirably is enhanced.

Abstract: The invention relates to fillers for plastics formulations based on polyurethane and the use thereof.

Abstract: Method of manufacturing dental restorations using curable compositions including degradable macromonomers having one or more terminal acrylate or methacrylate functionality, a curing composition, a filler composition including bioactive particles of bioactive glass, bioactive glass-ceramics, calcium phosphates, calcium apatites, or mixtures thereof and optionally one or more polymerizable acrylate or methacrylate comonomers. Degradable macromonomers are manufactured from cyclic monomers with compounds having acrylate or methacrylate functionality. Depending on their use, the degradable macromonomer compositions further include one or more organic or inorganic fillers, including a calcium-based compound and/or a radiopacity-imparting agent. The compositions are particularly suitable for root canal sealants, implants, bone cements, and pulp capping materials.

Abstract: A low shrinkage, polymerizable oligomer comprises units of the structure:

Abstract: A shelf-stable two-part self-adhering dental composition and method.

Abstract: The preferred embodiment of the present invention provides novel and unique fused fibrous compounds for addition to and manufacture of bone and dental cement systems and methods of making the same. The preferred embodiment of the fused fibrous compound material made therefrom comprises a rigid three-dimensional network of fibers fused together at their points of contact wherein said network is greater than 60% by volume void space, has mean pore diameters greater than 10 microns, or both. The fused fibrous compound is preferably manufactured from fibers and a fusion source and is added to the composition in particle form.