Composition Suitable For Use As Tissue Or Body Member Replacement, Restorative, Or Implant Patents (Class 523/113)
  • Patent number: 10668182
    Abstract: The present invention relates to a method for preparing a medical material for replacing a hard tissue defect and a medical material produced therefrom. More specifically, in the present invention, powders of bioactive glass are press-molded, and are then subjected to a first heat treatment at a relatively low temperature below the glass transition temperature of bioactive glass. Then, the resultant is processed into a desired shape and then subjected to a second heat treatment at a temperature higher than the glass transition temperature of bioactive glass. Accordingly, the present invention provides a medical material which can be customized to a desired shape of a hard tissue defect in a living body and minimize thermal shock, and which is capable of exhibiting a bone fusion property, while overcoming the low compressive strength drawback of hydroxyapatite, which is an existing hard tissue replacement material currently in use.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: June 2, 2020
    Assignee: Bioalpha Corporation
    Inventors: Mi Young Ryu, Sung Nam Park, Jun Hyuk Seo, Hyun Seung Ryu
  • Patent number: 10653785
    Abstract: A collagen material is characterized in being constituted of collagen gel fragments. Furthermore, the collagen gel fragments may have an orientation. A method for producing a collagen material is characterized in comprising a step for preparing collagen gel fragments, a step for arranging the collagen gel fragments in a desired shape, and a step for drying the collagen gel fragments arranged in the desired shape. Moreover, in one embodiment of the method for producing a collagen material a step may include imparting an orientation to the collagen gel fragments.
    Type: Grant
    Filed: February 20, 2012
    Date of Patent: May 19, 2020
    Assignee: Atree, Inc.
    Inventors: Taro Saku, Yoshihiro Isobe, Takaoki Isobe
  • Patent number: 10486136
    Abstract: A substrate includes a double-network polymer system including a cross-linked, covalently-bonded polymer and a reversible, partially ionicly-bonded polymer, wherein the substrate has a moisture level less than or equal to 15 percent of the total weight of the substrate, wherein the substrate is porous, and wherein the substrate includes a latent retractive force. A method for manufacturing a substrate includes producing a double-network hydrogel including a cross-linked, covalently-bonded polymer and a reversible, ionicly-bonded polymer; elongating by force the double-network hydrogel in at least one direction; treating the double-network hydrogel with an organic solvent with a volatile and water-miscible organic solvent to replace a majority of water within the double-network hydrogel; evaporating the organic solvent while the double-network hydrogel is still elongated to form a substantially-dried double-network polymer system; and releasing the force to produce the substrate.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: November 26, 2019
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventor: Xuedong Song
  • Patent number: 10406503
    Abstract: A substrate includes a double-network polymer system including a cross-linked, covalently-bonded polymer and a reversible, partially ionicly-bonded polymer, wherein the substrate has a moisture level less than or equal to 15 percent of the total weight of the substrate, wherein the substrate is porous, and wherein the substrate includes a latent retractive force. A method for manufacturing a substrate includes producing a double-network hydrogel including a cross-linked, covalently-bonded polymer and a reversible, ionicly-bonded polymer; elongating by force the double-network hydrogel in at least one direction; treating the double-network hydrogel with an organic solvent with a volatile and water-miscible organic solvent to replace a majority of water within the double-network hydrogel; evaporating the organic solvent while the double-network hydrogel is still elongated to form a substantially-dried double-network polymer system; and releasing the force to produce the substrate.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: September 10, 2019
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventor: Xuedong Song
  • Patent number: 10392472
    Abstract: A biodegradable cross-linked polymer and methods of preparing same are provided. The biodegradable cross-linked polymer is formed from a biodegradable polymeric material having two or more arms, which is a random copolymer formed of a first monomer and a second monomer different from the first monomer. The first monomer is selected from the group consisting of L-lactide, DL-lactide, glycolid, ?-caprolactone, trimethylene carbonate, p-dioxanone, amino acid-derived polycarbonates and polyorthoesters. The second monomer is one or two selected from the group consisting of D-lactide, DL-lactide, glycolide, ?-caprolactone, trimethyl carbonate, salicylic acid, carbonates, amino acids and derivatives thereof. The biodegradable polymeric material has a molecular weight of from 5,000 to 1,200,000 and an intrinsic viscosity of from 0.1 to 9.0 dl/g. Each of the terminal groups on the arms of the biodegradable polymeric material is selected from the group consisting of hydroxyl amino and carboxyl groups.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: August 27, 2019
    Assignee: Shanghai Microport Medical (Group) Co., Ltd.
    Inventors: Hongyan Jiang, Qiyi Luo, Juan Hou, Yahong Kang, Jing Wang, Wei Wang
  • Patent number: 10253193
    Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: April 9, 2019
    Assignee: Surmodics, Inc.
    Inventors: Aleksey V. Kurdyumov, Dale G. Swan
  • Patent number: 10206773
    Abstract: An accommodating IOL comprises an optic adapted to focus light toward a retina of an eye, and a movement assembly coupled to the eye to provide effective accommodating movement, preferably axial movement, of the optic. At least a portion of the movement assembly is made from a material that is less stiff and/or more resilient than the material used to make the optic. Optionally, an outer ring or support portion made at least partially from either a relatively stiff material such as the material used in the optic or a relatively resilient material such as the material used in the movement assembly is also provided.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: February 19, 2019
    Assignee: Johnson & Johnson Surgical Vision, Inc.
    Inventors: Marlene L. Paul, Michael D. Lowery, Daniel G. Brady, Arlene Gwon
  • Patent number: 10207023
    Abstract: A preparation at least useful as a bone implant is provided, which contains a solid component including a lithium compound and a calcium compound. The preparation shows an anti-bacterial ability in comparison with a preparation contains the calcium compound but free of the lithium compound.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: February 19, 2019
    Assignee: NATIONAL CHENG KUNG UNIVERSITY
    Inventors: Jiin-Huey Chern-Lin, Chien-Ping Ju, Chang-Keng Chen, Bing-Chen Yang
  • Patent number: 10206946
    Abstract: Preferred embodiments relate to compositions of inherently radiopaque, biocompatible, bioresorbable polymeric particles and methods of using them for embolizing a body lumen.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: February 19, 2019
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Donald K. Brandom, Eric Schmid, Joan Zeltinger, Durgadas Bolikal, Joachim B. Kohn
  • Patent number: 10195308
    Abstract: Methods of preparing bioactive composites are described. Also described are methods of molding such composites. Shaped bodies comprising bioactive composites are further described.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: February 5, 2019
    Assignee: Orthovita, Inc.
    Inventors: James P. Murphy, Erik M. Erbe, Charanpreet S. Bagga, Marissa M. Conrad
  • Patent number: 10184031
    Abstract: Various embodiments disclosed relate to melt-stabilized materials including ultra high molecular weight polyethylene (UHMWPE), methods of making the same, and medical implants including the same. In various embodiments, the present invention provides a method of melt-stabilizing a material including UHMWPE. The method includes obtaining or providing a solid material including UHMWPE including a first concentration of free-radicals. The method includes coating at least part of the solid material with a liquid composition including at least one antioxidant, to provide a coated solid material. The method includes heating the coated solid material in an environment including oxygen, the heating being sufficient to melt at least part of the UHMWPE, to provide a heated material.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: January 22, 2019
    Assignee: Zimmer, Inc.
    Inventor: Dirk Pletcher
  • Patent number: 10106402
    Abstract: Disclosed are biomedical implants comprising surface-modified metal particles and biodegradable polymers; its use for suppressing inflammation; and a method for preparing a biomedical material, comprising: (a) modifying surface of basic metal particles with a polymer to obtain surface-modified metal particles; and (b) mixing the surface-modified metal particles with a biodegradable polymer, followed by manufacturing a biodegradable biomedical implant, or coating the resulting mixture on a conventional biomedical implant.
    Type: Grant
    Filed: January 6, 2011
    Date of Patent: October 23, 2018
    Assignee: Korea Institute of Science and Technology
    Inventors: Dong Keun Han, Kwi Deok Park, Jong Hee Kang, Bong Soo Lee, Ji Yeon Choi, Chang Hun Kum
  • Patent number: 10076538
    Abstract: In one aspect, methods of promoting bone growth are described herein. In some embodiments, a method of promoting bone growth described herein comprises promoting cell differentiation or phenotype progression in a population of bone cells by providing a citrate-presenting composition to the population of bone cells. In some embodiments, the citrate-presenting composition is provided to the bone cells at a first stage of cell development selected to obtain a first cell differentiation or phenotype progression. Additionally, in some cases, a second citrate-presenting composition is further provided to the bone cells at a second stage of cell development selected to obtain a second cell differentiation or phenotype progression.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: September 18, 2018
    Assignee: Board of Regents, The University of Texas System
    Inventor: Jian Yang
  • Patent number: 10035871
    Abstract: Among other things, the present disclosure provides compositions and methods for an elastomeric cross-linked polyester material. Such an elastomeric cross-linked polyester material, in some embodiments, comprises a plurality of polymeric units of the general formula (-A-B—)p, wherein p is an integer greater than 1; and a plurality of urethane cross-links each of which covalently links two polymeric units to one another, which two linked polymeric unit each had at least one free hydroxyl or amino group prior to formation of the crosslink.
    Type: Grant
    Filed: August 26, 2012
    Date of Patent: July 31, 2018
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., Biocant-Center of Innovation and Biotechnology
    Inventors: Robert S. Langer, Jeffrey M. Karp, Maria Jose Maio Nunes-Pereira, Ben Ouyang, Lino Da Silva Ferreira, Debanjan Sarkar
  • Patent number: 9913926
    Abstract: Described herein is the synthesis of adhesive complex coacervates and their use thereof. The adhesive complex coacervates are composed of a mixture of one or more polycations and one or more polyanions. The polycations and polyanions in the adhesive complex coacervate are crosslinked with one another by covalent bonds upon curing. The adhesive complex coacervates have several desirable features when compared to conventional bioadhesives, which are effective in water-based applications. The adhesive complex coacervates described herein exhibit good interfacial tension in water when applied to a substrate (i.e., they spread over the interface rather than being beaded up). Additionally, the ability of the complex coacervate to crosslink intermolecularly increases the cohesive strength of the adhesive complex coacervate.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: March 13, 2018
    Assignee: University of Utah Research Foundation
    Inventors: Russell J. Stewart, Hui Shao
  • Patent number: 9877808
    Abstract: The present invention provides a membrane for guided regeneration of bone and tissue comprising an organic base material and a new bone formation guide layer on one or both sides of the organic base material, the new bone formation guide layer containing a hydrophilic polymer and calcium phosphate.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: January 30, 2018
    Assignee: HITACHI CHEMICAL COMPANY, LTD.
    Inventors: Hiroko Noda, Tetsushi Maruyama
  • Patent number: 9855195
    Abstract: The present invention provides a dental curable composition used for dental filling restorative materials, dental crown prosthesis materials such as inlays, crowns, and bridges, materials for constructing anchor teeth, block materials for dental CAD/CAM, etc. More specifically, the present invention provides a dental curable composition comprising a curable resin (A), a porous inorganic filler (B), and a polymerization initiator (C), wherein the porous inorganic filler (B) comprises a silicon dioxide, and an oxide comprising at least one kind of the other metallic elements, and a ratio (I1/I2) of a maximum absorbance (I1) of 3730 to 3750 cm?1 to a maximum absorbance (I2) of 3000 to 3600 cm?1 in infrared absorption spectrum of the porous inorganic filler (B), is not less than 1 and not more than 3.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: January 2, 2018
    Assignees: KABUSHIKI KAISHA SHOFU, JGC CATALYSTS AND CHEMICALS LTD.
    Inventors: Shuhei Takahashi, Hidefumi Fujimura, Jun Uchida, Mitsuji Teramae, Kunio Hori, Naoyuki Enomoto
  • Patent number: 9839498
    Abstract: To provide a multilayer resin material for dental milling and machining, comprising an inorganic filler in a content of 40% by weight or more and a plurality of layers different in transparency and color tone from each other, wherein the thickness of the uppermost layer (U) and the thickness of the lowermost layer (L) are each 1 mm or more, the contrast ratios (uppermost layer: CU, lowermost layer: CL) as indices for the transparency of the uppermost layer (U) and the transparency of the lowermost layer (L) satisfy the following relations: 0.30?CU?0.60 0.55?CL?0.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: December 12, 2017
    Assignee: SHOFU INC.
    Inventors: Masanori Goto, Toshio Kitamura, Mitsuji Teramae
  • Patent number: 9833537
    Abstract: A calcium-based bone cement formula having a powder component and a setting liquid component with a liquid to powder ratio of 0.20 ml/g to 0.50 ml/g is provided, wherein the powder component includes tetracalcium phosphate. The bone cement formula further contains, based on the total weight of the bone cement formula, 0.01-1% of poly(acrylic acid) having a repeating unit of —(CH2—C(COOH)H)n-, wherein n=50-50000.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: December 5, 2017
    Assignee: NATIONAL CHENG KUNG UNIVERSITY
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju
  • Patent number: 9632654
    Abstract: A system and method to present global and local context sensitive augmented content in accordance with multiple criteria, including one or more user's preferences, and present the augmented content via a transparent layer on top of the original content for less obtrusive and more efficient browsing, knowledge discovery and exploration experience. The original content remains visible to the user while the augmented content is being viewed or interacted with. The global context sensitive augmented content is generated using metrics based on the overall document or content being viewed, while the local context sensitive augmented content is generated using metrics based on the currently viewed or selected object within the document or content being viewed. Real-time and theme based augmentation are used to further enhance the user's experience.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: April 25, 2017
    Inventor: Shauki Elassaad
  • Patent number: 9597155
    Abstract: A medical device that may be implanted in a patient's body is disclosed. An illustrative medical device has an elongated structure that includes a material loaded with a radiopaque material. The radiopaque material includes radiopaque particles having multiple sets of radiopaque particles. The multiple sets of radiopaque particles may include a first set of radiopaque particles having particles with particle sizes in a first particle size range and a second set of radiopaque particles having particles with particle sizes in a second particle size range. The second set of radiopaque particles may have particles configured to fit within interstitial spaces between particles of the first set of radiopaque particles.
    Type: Grant
    Filed: February 13, 2014
    Date of Patent: March 21, 2017
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Scott R. Schewe, Benjamin P. Gundale
  • Patent number: 9580560
    Abstract: The disclosure is directed to polymer ligands that are optimally suited for surface-functionalizing magnetic nanoparticles. The amphiphilic polymers are prepared by coupling several amine-terminated anchoring groups, polyethylene glycol moieties, and reactive groups onto a poly(isobutylene-alt-maleic anhydride) (PIMA) chain. The reaction of maleic anhydride groups with amine-containing molecules is highly-efficient and occurs in one-step. The availability of several dopamine groups in the same ligand greatly enhances the ligand affinity, via multiple-coordination, to the magnetic NPs, while the hydrophilic and reactive groups promote colloidal stability in buffer media and allow subsequent conjugation with target biomolecules. Nanoparticles ligated with terminally reactive polymers have been easily coupled to target dyes and tested in live cell imaging with no measurable cytotoxicity.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: February 28, 2017
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Hedi Mattoussi, Wentao Wang, Goutam Palui
  • Patent number: 9526815
    Abstract: A nanocomposite hydrogel formed from free radical dissociation of an initiator and polymerization of a water soluble monomer. The resulting hydrogel finds particular application within the medical field for both soft and hard tissue repair in human and animals. The hydrogel is particularly advantageous for spinal disc repair.
    Type: Grant
    Filed: August 21, 2012
    Date of Patent: December 27, 2016
    Assignee: SHEFFIELD HALLAM UNIVERSITY
    Inventors: Victoria L. Boyes, Chris Sammon, Christine Lemaitre, Chris Breen
  • Patent number: 9433647
    Abstract: A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts. Preferably, the drying fixture includes grooves or raised edges that define the outer contours of each desired tissue graft, after they are cut, and further includes raised or indented logos that emboss the middle area of the tissue grafts during dehydration and that enables an end user to distinguish the top from the bottom side of the graft. The grafts are comprised of single layers of amnion or chorion, multiple layers of amnion or chorion, or multiple layers of a combination of amnion and chorion.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: September 6, 2016
    Assignee: MiMedx Group, Inc.
    Inventor: John Daniel
  • Patent number: 9381140
    Abstract: The invention relates to a polymerizable dental material containing a) at least one curable aliphatic and/or cycloaliphatic monomer system having a refractive index that is measured at 23° C. and a wavelength of 589 nm of less than or equal to 1.50 that contains at least one aliphatic and/or cycloaliphatic bis(meth)acrylate and/or at least one aliphatic and/or cycloaliphatic bis(meth)acrylamide; and b) 15 to 80% by weight relative to the total mass of the dental material of at least one filler selected from the group of fused silica having a refractive index that is measured at 23° C. and a wavelength of 589 nm of 1.45 to 1.47, or cristobalite with a refractive index that is measured at 23° C. and a wavelength of 589 nm of 1.48 to 1.49, or combinations thereof. The radically polymerizable dental material has excellent storage properties and is formulated, in particular, as a two-component mixture containing components A and B.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: July 5, 2016
    Assignee: Kettenbach GmbH & Co. KG
    Inventors: Alexander Bublewitz, Jens-Peter Reber, Alexander Theis
  • Patent number: 9307965
    Abstract: A staple cartridge assembly for use with a surgical stapler. The assembly has a cartridge body having a support portion with a plurality of staple cavities with openings. There is also a plurality of staples, wherein at least a portion of each the staple is removably stored within a the staple cavity. Each the staple is movable between an unfired position and a fired position, and is deformable between an unfired configuration and a fired configuration. The assembly also includes a compressible tissue thickness compensator configured to be captured within the staples. The compressible tissue thickness compensator at least partially covers the staple cavity openings. The compressed tissue thickness compensator is configured to assume different compressed heights within different the staples. The compressible tissue thickness compensator comprising a lyophilized foam having an anti-microbial agent embedded therein.
    Type: Grant
    Filed: June 25, 2012
    Date of Patent: April 12, 2016
    Assignee: Ethicon Endo-Surgery, LLC
    Inventors: Xintian Ming, Thomas W. Huitema, Stephen J. Rothenburger, Frederick E. Shelton, IV
  • Patent number: 9233189
    Abstract: The invention pertains to a biocompatible composition, suitable for use in soft or hard tissue augmentation, wherein the composition is an aqueous suspension containing a carrier fraction of ceramic particles of less than 15 ?m and an augmentation fraction of ceramic particles of at least 20 ?m. The ceramics typically include calcium phosphate. The composition is a may be used in soft tissue repair as well as hard bone replacement. It advantageously avoids the need for foreign body materials which are conventionally applied to stabilize augmentation suspensions.
    Type: Grant
    Filed: November 26, 2012
    Date of Patent: January 12, 2016
    Assignee: Cam Bioceramics B.V.
    Inventors: Klaas De Groot, Nienke de Roode-Beuling, Nol Van De Mortel, Mariska Bezemer
  • Patent number: 9161987
    Abstract: Compositions comprising carboxypolysaccharides (CPS) including carboxymethyl cellulose (CMC) and polyethylene glycols (PEGs) are provided where the PEG is a PEG-epoxide covalently linked to the CPS. In certain embodiments, the PEG attaches to only one CPS, forming a decorated CPS. In other embodiments, bi-functional PEG molecules are attached to adjacent CPSs, thereby forming a covalently cross-linked composition. Additional embodiments include PEG/CMC compositions where the PEG is a multi-branch PEG and/or a multi-arm PEG. PEG/CMC compositions can be made with desired viscoelastic properties, and such compositions can be used as space-filling materials, load-bearing materials, anti-adhesion compositions, drug delivery vehicles or lubrication of tissues and medical instruments.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: October 20, 2015
    Assignee: FzioMed, Inc.
    Inventors: Samuel J. Falcone, Richard A. Berg
  • Patent number: 9156772
    Abstract: Chelating monomers and fluoride-releasing compositions are disclosed that may be incorporated into dental composite restorative materials, dental bonding agents or other dental materials, to produce materials with high fluoride release rates, and high fluoride recharge capability. Such dental restorative materials may help reduce the level of dental caries in patients, particularly the level of caries occurring on the margins of the restorative materials.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: October 13, 2015
    Inventors: Xiaoming Xu, Shailaja Jayaramachandran
  • Patent number: 9138511
    Abstract: A bioabsorbable blend comprising poly(L-lactide) (PLLA) and a phosphorylcholine group-containing copolymer (PPCP) capable of enduring the mechanical strength of blood vessel walls and applicable for fabricating cardiovascular devices was developed. The blend acts as a scaffold to support blood vessel walls during vascular healing and undergoes biodegradation in vivo after vascular healing is complete. Furthermore, the blend can prevent the formation and adsorption of thrombi.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: September 22, 2015
    Assignees: SUNTECH Co., Ltd
    Inventors: Hyung-Il Kim, Kazuhiko Ishihara
  • Patent number: 9090868
    Abstract: Alginate hydrogel fibers and related materials as well as methods for preparing such materials are provided. An alginate hydrogel fiber includes water in an amount of more than about 92% by weight of the fiber and a cross-linked alginate in an amount of about 0.1% to about 8% by weight of the fiber, wherein the cross-link is a cation. An alginate hydrogel paper includes one or more alginate hydrogel fibers, which form a non-woven matrix. Three-dimensional cellular arrays are also provided, wherein the alginate hydrogel making up the alginate paper is substantially index-matched with a predetermined culture medium. A method for making alginate hydrogel fiber and a method for index-matching alginate hydrogel paper with culture medium are provided. A kit for conducting biochemical, diagnostic, cellular, and/or non-cellular analysis comprises alginate hydrogel paper index-matched to culture medium.
    Type: Grant
    Filed: July 12, 2011
    Date of Patent: July 28, 2015
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Charles R. Mace, Jabulani Barber, Anna Laromaine Sagué, George M. Whitesides, Rebecca Cademartiri
  • Patent number: 9034361
    Abstract: Hydroswellable, absorbable and non-absorbable, aliphatic, segmented polyurethanes and polyurethane-urea capable of swelling in the biological environment with associated increase in volume of at least 3 percent have more than one type of segments, including those derived from polyethylene glycol and the molecular chains are structurally tailored to allow the use of corresponding formulations and medical devices as carriers for bioactive agents, rheological modifiers of cyanoacrylate-based tissue adhesives, as protective devices for repairing defective or diseased components of articulating joints and their cartilage, and scaffolds for cartilage tissue engineering.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: May 19, 2015
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, Joel T. Corbett, Michael Aaron Vaughn, David R. Ingram
  • Publication number: 20150118152
    Abstract: Compositions of P4HB (poly-4-hydroxybutyrate) and copolymers thereof, have been developed for pultrusion, as well as processes to produce profiles from these compositions by pultrusion. These pultrusion processes provide profiles without causing structural damage to the surface of the profile. The profiles may be used in medical applications. These compositions include P4HB, and copolymers thereof, having intrinsic viscosities less than 3.2 dl/g but greater than 0.8 dl/g. The profile may be formed using conditions such as: pull rate of 0.1 to 100 mm/min, die temperature of up to 95° C., rod stock temperature up to 95° C., draw ratio of up to 100×, pulling force of greater than 10 MPa, and clamping pressure at least 10% higher than the pulling force. Preferably, the profile is formed by pulling the rod stock through a series of dies placed at intervals with the hole sizes decreasing in diameter by 0.1 to 10 mm.
    Type: Application
    Filed: October 30, 2014
    Publication date: April 30, 2015
    Inventors: Amit Ganatra, Bhavin Shah, Said Rizk, David P. Martin, Simon F. Williams
  • Patent number: 9012415
    Abstract: This invention refers to photo-crosslinked hydrogel materials based in gellan gum suitable for tissue engineering and regenerative medicine applications or as drug delivery systems. Formulations of gellan gum with different degrees of acylation serve as precursor material for insertion of a polymerizable moiety. The materials are capable of free radical polymerization with a photo-initiator at mild temperatures and exposure to ultraviolet light, enabling control of reticulation and withstanding the encapsulation of human and animal cells and/or drugs, and any combination thereof. The physicochemical and biological properties can be adjusted by combining different formulations of gellan gum and reaction conditions.
    Type: Grant
    Filed: March 26, 2011
    Date of Patent: April 21, 2015
    Assignee: Stemmatters, Biotecnologia e Medicina Regenerativa S.A.
    Inventors: Joana Catarina Da Silva Correia, Joaquim Miguel Antunes De Oliveira, João Manuel Teixeira De Oliveira, Rui Pedro Amandi Romero De Sousa, Rui Luis Gonçalves Dos Reis
  • Patent number: 9000066
    Abstract: The present disclosure relates to a multi-modal shape memory polymer material comprising a blend of at least one polymer component having a first molecular weight and at least a second polymer component having a second molecular weight that is less than the first component.
    Type: Grant
    Filed: April 18, 2008
    Date of Patent: April 7, 2015
    Assignee: Smith & Nephew, Inc.
    Inventors: Malcolm Brown, Horacio Montes De Oca Balderas, Michael Hall, John Rose
  • Publication number: 20150071871
    Abstract: A bio-synthetic matrix comprising a hydrogel which is formed by cross-linking a synthetic polymer and a bio-polymer is provided. The matrix is robust, biocompatible and non-cytotoxic and is capable of supporting cell in-growth in vivo. The matrix can be tailored to further comprise one or more bioactive agents. The matrix may also comprise cells encapsulated and dispersed therein, which are capable of proliferating upon deposition of the matrix in vivo. Methods of preparing the bio-synthetic matrix and the use of the matrix in vivo for tissue engineering or drug delivery applications are also provided.
    Type: Application
    Filed: April 11, 2014
    Publication date: March 12, 2015
    Inventors: May GRIFFITH, David J. CARLSSON, Fengfu LI
  • Patent number: 8975309
    Abstract: A cryogel-forming vinyl alcohol co-polymer is operable to form a cryogel, i.e., a hydrogel formed by crytropic gelation, in an aqueous solution at a concentration of less than about 10% by weight, in the absence of a chemical cross-linking agent and in the absence of an emulsifier. In one embodiment, a vinyl alcohol co-polymer cryogel comprises at least about 75% by weight water and a vinyl alcohol co-polymer, wherein the vinyl alcohol co-polymer is operable to form a cryogel in an aqueous solution at a concentration of less than about 10% by weight, in the absence of a chemical cross-linking agent and in the absence of an emulsifier.
    Type: Grant
    Filed: September 14, 2009
    Date of Patent: March 10, 2015
    Inventors: Maria Stromme, Albert Mihranyan
  • Patent number: 8968760
    Abstract: A method for attaching an implant to tissue is disclosed. In embodiments, a method includes applying a sprayable material to tissue, the sprayable material possessing functional groups capable of binding to tissue. The sprayable material also possesses functional groups capable of binding to an implant. In embodiments, the functional groups capable of binding to an implant include nucleotides. In such a case, the implant possesses complementary nucleotides capable of binding to the nucleotides on the sprayable material, thereby permitting hydrogen binding between the two. The implant may thus be affixed to tissue, and repositioned as necessary, prior to more permanent attachment utilizing means such as sutures, tacks, etc.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: March 3, 2015
    Assignee: Covidien LP
    Inventors: Timothy Sargeant, Jonathan Thomas
  • Patent number: 8969430
    Abstract: A hydroxyapatite ceramic hybrid material includes a hydroxyapatite ceramic structure having pores therein and a biodegradable polymer included in the pores in the hydroxyapatite ceramic structure. The biodegradable polymer can be a poly L-lactic acid polymer. A method for preparing a hydroxyapatite ceramic-biodegradable polymer hybrid material includes preparing a porous hydroxyapatite ceramic containing pores having an average pore diameter of 10 ?m or larger; and forming a biodegradable polymer in the pores of the porous hydroxyapatite ceramic. The porous hydroxyapatite ceramic may be prepared by: preparing a slurry comprising hydroxyapatite fibers and heat-degradable particles in a selected solvent; filtering the slurry to obtain a paste; preparing a molded body using the paste; compacting the molded body to produce a green compact; and firing the green compact at a temperature at least 1000° C. to produce a porous hydroxyapatite ceramic structure.
    Type: Grant
    Filed: November 18, 2009
    Date of Patent: March 3, 2015
    Assignee: Showa-Ika Kogyo Co. Ltd.
    Inventors: Mamoru Aizawa, Masahiro Rikukawa
  • Publication number: 20150056131
    Abstract: Methods to produce thermoforms from P4HB homopolymer and blends thereof have been developed. These thermoforms are produced from films and sheets including P4HB, wherein the intrinsic viscosity of the P4HB is less than 3.5 dl/g, but greater than 0.35 dl/g, and the thermoforms are produced at a temperature equal to or greater than the softening point of P4HB, and more preferably at a temperature higher than the melting point of P4HB. A preferred embodiment includes a P4HB thermoform wherein a film or sheet including a P4HB polymer is thermoformed at a temperature between its melting point and 150° C. In a particularly preferred embodiment the thermoform is a laminate made from a P4HB film and a P4HB mesh.
    Type: Application
    Filed: August 20, 2014
    Publication date: February 26, 2015
    Inventors: Matthew Bernasconi, Dennis Connelly, Said Rizk, David P. Martin, Simon F. Williams
  • Patent number: 8957126
    Abstract: The present application provides dental compositions, and methods of making and using dental compositions that include a calcium and phosphorus releasing glass. Such dental compositions can be useful for delivering ions to the oral environment.
    Type: Grant
    Filed: November 7, 2005
    Date of Patent: February 17, 2015
    Assignee: 3M Innovative Properties Company
    Inventors: Richard P. Rusin, Kevin M. Cummings, Sumita B. Mitra, Paul A. Burgio, Tsi-Zong Tzou, David S. Arney
  • Patent number: 8956638
    Abstract: A method is provided for the preparation of a poly(amic acid) in which ring opening polymerization is employed to react the monomers ethylenediaminetetraacetic dianhydride and paraphenylenediamine in an aprotic solvent. The resulting poly(amic acid) composition is suitable as a biocompatible material, such as a biomedical implant, implant coating material, tissue scaffold material, controlled release drug delivery vehicle, and cellular growth substrate.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: February 17, 2015
    Assignee: Axcelon Biopolymers Corporation
    Inventors: Wankei Wan, Donna Padavan
  • Publication number: 20150044092
    Abstract: The invention relates in various embodiments to a composite useful as e.g. a medical implant device, and a method of treating fouling, including biofouling as may occur on an implant. The composite comprises a matrix phase and a patterned phase that comprises an energetically activatable wire intermixed with the matrix phase, the wire when energetically activated, which includes thermal activation, causes modification of at least a portion of the matrix phase to treat fouling that might otherwise occur. The method of treating biofouling may be practiced on a patent while the medical implant of the invention is in situ.
    Type: Application
    Filed: August 5, 2014
    Publication date: February 12, 2015
    Inventors: Steve L. ALLMAN, Mitchel J. DOKTYCZ, Scott T. RETTERER, David P. ALLISON
  • Publication number: 20150045909
    Abstract: A method of making a creep resistant, highly lubricious, tough hydrogel includes the steps of preparing a first solution including polyacrylamide-co-acrylic acid and another polymer, such as polyvinyl alcohol), and introducing a second solution a gellant into the first solution to form the hydrogel. The first solution can be heated to a first temperature above room temperature, and the combination of the first solution and the second solution can be cooled to a second temperature at or below room temperature. The hydrogel can be used for cartilage repair or in an interpositional device that requires mechanical integrity, high water content, and excellent lubricity in order to fully function under the high stress environment in the joint space and withstand high loads of human joints.
    Type: Application
    Filed: February 22, 2012
    Publication date: February 12, 2015
    Inventors: Orhun K. Muratoglu, Hatice Bodugoz-Senturk
  • Publication number: 20150038613
    Abstract: The invention features a composition comprising a self-healing interpenetrating network hydrogel comprising a first network and a second network. The first network comprises covalent crosslinks and the second network comprises ionic or physical crosslinks. For example, the first network comprises a polyacrylamide polymer and second network comprises an alginate polymer.
    Type: Application
    Filed: January 7, 2013
    Publication date: February 5, 2015
    Inventors: Jeong-Yun Sun, Xuanhe Zhao, Widusha R.K. Illeperuma, Kyu Hwan Oh, Joost J. Vlassak, Zhigang Suo, Jianyu Li, David J. Mooney
  • Patent number: 8920516
    Abstract: A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.
    Type: Grant
    Filed: January 26, 2010
    Date of Patent: December 30, 2014
    Assignees: Cook Biotech Incorporated, Cook Medical Technologies LLC
    Inventors: William A. Cook, Michael C. Hiles, Thomas G. Kozma, Umesh H. Patel
  • Patent number: 8921450
    Abstract: The invention relates to a radically polymerizable monomer of formula (I) wherein W1 and W2 in each case independently represent H or X—R—Y—PG, wherein at least one of W1 and W2 represents X—R—Y—PG, X in each case independently is missing or represents an ether, ester, amide, urethane or urea group, Y in each case independently is missing or represents an ether, ester, amide, urethane or urea group, R in each case independently is missing or represents a C1-C16 alkylene radical which can be interrupted by one or more O atoms, wherein R can be missing only if X and/or Y is simultaneously also missing, and PG in each case independently represents a cyclic, ring-opening polymerizable group, a, b, c and d independently of each other can take the values 3 to 10.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: December 30, 2014
    Assignee: Ivoclar Vivadent AG
    Inventors: Norbert Moszner, Jörg Angermann, Urs Karl Fischer, Volker Rheinberger
  • Patent number: 8916624
    Abstract: Improvedly storage stable dental compositions useful for the preparation of dental prostheses and for dental restoration containing a uniquely pretreated dental filler material.
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: December 23, 2014
    Assignee: Bluestar Silicones France SAS
    Inventors: Jean-Marc Frances, Sophie Schneider
  • Publication number: 20140369954
    Abstract: The disclosed subject matter can provide a nanotube-reinforced polymer composite material comprising a plurality of nanotubes, each nanotube being formed of a plurality of cyclic peptide molecules, disposed within a polymer matrix, such as a biodegradable polymer matrix. A cyclic polymer, such as a cyclic 8-mer, composed of amino acid residues of alternating absolute configurations (D/L, R/S), can self-assemble into nanotubes useful for preparation of the composite polymer material of the invention. For example, the cyclic peptide (QL)4, wherein the glutamine and leucine residues are of opposite absolute configuration, self-assembles into nanotubes, which when formed into a reinforced polymer composite including poly(caprolactone), provides a biocompatible material of greater tensile strength and Young's modulus compared to the poly(caprolactone) material alone. The nanotubes can be prepared by a vapor equilibration technique or by a solvent-nonsolvent precipitation technique.
    Type: Application
    Filed: November 26, 2012
    Publication date: December 18, 2014
    Applicant: President and Fellows of Harvard College
    Inventors: Neel Satish Joshi, Daniel James Rubin
  • Patent number: 8912247
    Abstract: Improved methods for preparing polyethylene glycol fumarate) are disclosed. Methods for chemically crosslinking or photocross-linking hydrophilic polyethylene glycol fumarate) with hydrophobic polymers such as poly(propylene fumarate) (PPF) and poly(caprolactone fumarate) (PCLF) to form various hydrogels (FIG. 1) with controllable hydrophilicity are also disclosed. The hydrogels are useful in the fabrication of injectable and in-situ hardening scaffolds for application in skeletal reconstruction. An injectable material including the hydrogels may be useful in controlled drug release.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: December 16, 2014
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Shanfeng Wang, Lichun Lu, Michael J. Yaszemski