Composition Suitable For Use As Tissue Or Body Member Replacement, Restorative, Or Implant Patents (Class 523/113)
  • Patent number: 11903627
    Abstract: A device for mixing a bone material with a liquid is provided. The device comprises a chamber having a proximal end and a distal end, and the bone material disposed within the chamber, the bone material comprising a coherent mass of milled and lyophilized demineralized bone fibers; and a plunger having at least a portion slidably disposed within the proximal end of the chamber and configured to dispense the bone material mixed with liquid from the distal end of the chamber, when the plunger is in an extended position.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: February 20, 2024
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Kelly W. Schlachter, Daniel A. Shimko, Kerem N. Kalpakci, Erick Vasquez, David R. Kaes, Subhabrata Bhattacharyya
  • Patent number: 11850108
    Abstract: A curable composite material containing nanodiamonds, denture bases and other dental prosthetics made from the composite material and methods for treating dental stomatitis using these prosthetics.
    Type: Grant
    Filed: June 22, 2023
    Date of Patent: December 26, 2023
    Assignee: Imam Abdulrahman Bin Faisal University
    Inventors: Mohammed Moustafa Ahmed Gad, Shaimaa Mohamed Said Fouda, Fahad A. Al-Harbi, Ahmad M. Al-Thobity, Passent Safwat Aly Ellakany
  • Patent number: 11845247
    Abstract: There is provided a composition for a laminated material used for a medical lubricating member, the composition including a polymer b including a polysiloxane structure, a catalyst for crosslinking reaction, and a crosslinking agent having a particular structure. The polymer b includes at least one of an acrylic acid component, an acrylic acid ester component, an acrylamide component, or a styrene component and has a hydroxy group, a carboxy group, an amino group, an isocyanate group, an oxazolinyl group, an epoxy group, a vinyl group, an ethynyl group, a sulfanyl group, an azide group, a trialkoxysilyl group, or an acid anhydride structure. There are also provided a laminated material and a medical lubricating member produced from the composition, a medical device including the laminated material and the medical lubricating member, and a method for producing the laminated material and the medical lubricating member.
    Type: Grant
    Filed: January 13, 2021
    Date of Patent: December 19, 2023
    Assignee: FUJIFILM Corporation
    Inventors: Yoshihiro Nakai, Sotaro Inomata
  • Patent number: 11844659
    Abstract: A curable composite material containing nanodiamonds, denture bases and other dental prosthetics made from the composite material and methods for treating dental stomatitis using these prosthetics.
    Type: Grant
    Filed: June 22, 2023
    Date of Patent: December 19, 2023
    Assignee: Imam Abdulrahman Bin Faisal University
    Inventors: Mohammed Moustafa Ahmed Gad, Shaimaa Mohamed Said Fouda, Fahad A. Al-Harbi, Ahmad M. Al-Thobity, Passent Safwat Aly Ellakany
  • Patent number: 11787909
    Abstract: Acrylamide-derived hydrogels and methods of fabrication thereof from an acrylic monomer, a crosslinking agent comprising an organosilicon compound, a polymerization initiator, a solvent and a polymerization accelerator, as well as their use in controlling circulation losses. The obtained hydrogels interact with the walls of the reservoir and exhibits an increase in viscosity, either at delayed times or in response to a given stimulus, such as changes in temperature, pressure, pH, salinity, using a simple and easily scalable methodology.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: October 17, 2023
    Assignees: YPF TECNOLOGIA S.A., UNIVERSIDAD DE BUENOS AIRES, CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET).
    Inventors: Joana Elisa Tasque, Pablo Alejandro Raffo, Isabel Natalia Vega, Norma Beatriz D'Accorso, Darío Alberto Contrera
  • Patent number: 11771802
    Abstract: The present disclosure pertains to ionic polymer compositions, including semi.- and fully interpenetrating polymer networks, methods of making, such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging, for such articles.
    Type: Grant
    Filed: May 20, 2022
    Date of Patent: October 3, 2023
    Assignee: Hyalex Orthopaedics, Inc.
    Inventors: Iraklis Kourtis, Jun Li, Lampros Kourtis
  • Patent number: 11760964
    Abstract: A plant fat-based scaffold for growing cell-based meat products for consumption. The scaffold comprises primarily plant fats or waxes in addition to cell binding proteins and optional additional components that assist in the growth of cultivated animal cells. The scaffold can exist in both a liquified state during sterilization and a solid state during the formation of the scaffold, the seeding of the cultivated cells, and the cellular growth phase. The scaffold is capable of remaining in the final product for consumption or is partially or completely melted out of the final product and recycled into raw material for forming new scaffolds.
    Type: Grant
    Filed: January 10, 2022
    Date of Patent: September 19, 2023
    Assignee: Upside Foods, Inc.
    Inventors: Konrad Muller-Aufferman, Michaela Walker
  • Patent number: 11752014
    Abstract: A proposed treatment of arthrosis/osteoarthritis in a joint of a mammal or human patient involves deposing a liquid material on at least one damaged surface of the joint. To accomplish this, a reservoir (110) is provided, which holds a volume of a biocompatible material in liquid form outside of a body containing the joint (J) to be treated. A proximal end (P) of a tube-shaped instrument (120) is connected to the reservoir (110), and a distal end (D) of the instrument (120) is inserted into the joint (J). The liquid material is fed through the instrument (120) to the distal end (D) for deposition on the at least one damaged joint surface. The material is configured to assume a solid form under predefined conditions (e.g. when cooling off, or being exposed to a specific type of radiation). When the material has the solid form, it has a resistance to wear adapted to replace a worn out joint surface.
    Type: Grant
    Filed: February 4, 2021
    Date of Patent: September 12, 2023
    Inventor: Peter Forsell
  • Patent number: 11708462
    Abstract: Methods of forming cross-linked polysaccharides are disclosed in which one or more polysaccharides are dissolved in solution, gelled, modified to have a desired concentration, and subsequently irradiated. The irradiation of the gel crosslinks the polysaccharide(s) present. The disclosed techniques may be applied to various polysaccharides, including but not limited to agarose and/or hyaluronic acid.
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: July 25, 2023
    Assignee: Advanced Aesthetic Technologies, Inc.
    Inventors: Richard Provonchee, Valentino Gitto, Leonard Miller
  • Patent number: 11699791
    Abstract: A binder for a secondary battery includes a copolymer having a first repeating unit, a second repeating unit, and a third repeating unit. A ratio of a number of the first repeating unit (A) and a sum of a number of the second repeating unit and a number of the third repeating unit (B) is 90:10 to 52:48. A ratio of the number of the second repeating unit and the number of the third repeating unit is 67:33 to 1:99. A weight average molecular weight of the copolymer is 225,000 to 2,000,000.
    Type: Grant
    Filed: August 13, 2020
    Date of Patent: July 11, 2023
    Assignee: SK ON CO., LTD.
    Inventors: Joon Sup Kim, Sun Young Kim, Dong Gun Lee, Jee Hee Lee
  • Patent number: 11648334
    Abstract: A bone gel composition consists of cortical bone. The cortical bone is made from cut pieces freeze-dried then ground into particles and demineralized then freeze-dried. A volume of the particles is placed in a solution of sterile water to create a mixture, the water volume being at least twice the particle volume, the mixture is autoclaved under heat and pressure to form a gelatin, the resulting bone gel is formed into sheets having a thickness (t).
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: May 16, 2023
    Assignee: Vivex Biologies Group, Inc.
    Inventors: Wendy W. Weston, Silvia Daniela Gonzales, Edgar S. Maldonado
  • Patent number: 11548995
    Abstract: A manufacturing method for porous resin microparticles comprising steps of: heating a polyester thermoplastic resin having biodegradability to a temperature of 80° C. or higher and 200° C. or lower in a glycol ether solvent to obtain a solution, and cooling the solution to precipitate the polyester thermoplastic resin as porous resin microparticles.
    Type: Grant
    Filed: November 30, 2020
    Date of Patent: January 10, 2023
    Assignee: SEKISUI PLASTICS CO., LTD.
    Inventors: Kaori Kuwagaki, Akiyoshi Kusaka
  • Patent number: 11529437
    Abstract: Disclosed are a biological tissue matrix material, a preparation method therefor and the use thereof in an otological repair material. The biological tissue matrix material comprises an extracellular matrix. The extracellular matrix comprises a collagen fiber, a growth factor and fibronectin. The biological tissue matrix material has a low amount of DNA residue, a low immunogenicity, a high anti-infection ability, and a strong repair capability.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: December 20, 2022
    Assignee: Beijing Biosis Healing Biological Technology Co., Ltd.
    Inventors: Bo Zhao, Hongquan Wang, Leilei Xia, Yanrui Zhao, Xuejun Li, Jinhui Zhang
  • Patent number: 11471559
    Abstract: A biological composition has a mixture of mechanically selected allogeneic biologic material derived from bone marrow. The mixture has non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components. The mixture including non-whole cell fractions including one or more of exosomes, transcriptosomes, proteasomes, membrane rafts, lipid rafts. The mixture is compatible with biologic function.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: October 18, 2022
    Assignee: Vivex Biologics Group, Inc.
    Inventors: Timothy Ganey, Wendy W. Weston, Miguel Quevedo, Stuart Oglesby, Tracy Scott Anderson
  • Patent number: 11458076
    Abstract: A polymerisable dental composite material comprising (i) 60 to 85% by weight of an inorganic filler component comprising at least one tectosilicate and optionally at least one dental glass and/or at least one amorphous metal oxide, (ii) 10 to 40% by weight of a mixture of at least two different urethane(meth)acrylates, (iii) 0.01 to 5% by weight of at least one di-, tri-, tetra- or multi-functional monomer not being a urethane(meth)acrylate, (iv) 0.01 to 10% by weight of at least one initiator, an initiator system and optionally at least one stabiliser and optionally at least one pigment, wherein the total composition of the composite material amounts to 100% by weight, and a polymerised composite material having a flexural strength of greater than or equal to 240 MPa and an elastic modulus of 16 to 20 GPa for the production of indirect dentures.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: October 4, 2022
    Assignee: KULZER GMBH
    Inventors: Andreas Utterodt, Kurt Reischl, Nelli Schönhof, Michael Eck, Raif Kocoglu, Jutta Schneider, Caroline Kempka
  • Patent number: 11426175
    Abstract: An expansile member that may be used on a delivery device or may be used for occlusive purposes within the vasculature.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: August 30, 2022
    Assignee: MicroVention, Inc.
    Inventors: Hideo Morita, Greg Bak-Boychuk, Arnold Tuason, Matthew J. Fitz, George R. Greene, Jr.
  • Patent number: 11351261
    Abstract: A composite implant comprising an injectable matrix material which is flowable and settable, and at least one reinforcing element for integration with the injectable matrix material, the at least one reinforcing element adding sufficient strength to the injectable matrix material such that when the composite implant is disposed in a cavity in a bone, the composite implant supports the bone.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: June 7, 2022
    Assignee: 206 ORTHO, INC.
    Inventors: Jeffrey A. D'Agostino, Robert S. Whitehouse, Andrew J. Carter, Arthur Watterson, Joseph P. Lane, Ian D. McRury, Samantha Marchetti, Nikole Seil
  • Patent number: 11324581
    Abstract: A silicone prosthesis delivery apparatus and associated methods are disclosed for facilitating the transport and subsequent insertion of a silicone prosthesis into a surgically developed pocket of a patient. In at least one embodiment, a flexible, substantially funnel-shaped delivery sleeve is configured for receiving and subsequently expelling the prosthesis therefrom. The delivery sleeve provides a substantially conical-shaped entry portion and a substantially conical-shaped exit portion, the entry portion and exit portion opposingly positioned and joined with one another so as to form a relatively larger diameter middle section. A tapered free end of the entry portion provides an entry opening configured for allowing the prosthesis to selectively pass therethrough when the prosthesis is inserted into the delivery sleeve.
    Type: Grant
    Filed: August 21, 2020
    Date of Patent: May 10, 2022
    Assignee: Conical Cover LLC
    Inventor: Scott Hyler Heneveld
  • Patent number: 11298444
    Abstract: Hydrogel compositions prepared from amine components and glycidyl ether components are provided which are biocompatible and suitable for use in vivo due, in part, to their excellent stability.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: April 12, 2022
    Assignee: TRIVASCULAR, INC.
    Inventors: Syed H. Askari, Robert G. Whirley
  • Patent number: 11254781
    Abstract: Among other things, the present disclosure provides compositions and methods for an elastomeric cross-linked polyester material. Such an elastomeric cross-linked polyester material, in some embodiments, comprises a plurality of polymeric units of the general formula (-A-B-)p, wherein p is an integer greater than 1; and a plurality of urethane cross-links each of which covalently links two polymeric units to one another, which two linked polymeric unit each had at least one free hydroxyl or amino group prior to formation of the crosslink.
    Type: Grant
    Filed: February 25, 2021
    Date of Patent: February 22, 2022
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., Biocant-Center of Innovation and Biotechnology
    Inventors: Robert S. Langer, Jeffrey M. Karp, Maria Jose Maio Nunes-Pereira, Ben Ouyang, Lino da Silva Ferreira, Debanjan Sarkar
  • Patent number: 11246884
    Abstract: Preferred embodiments relate to compositions of inherently radiopaque, biocompatible, bioresorbable polymeric particles and methods of using them for embolizing a body lumen.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: February 15, 2022
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Donald K. Brandom, Eric Schmid, Joan Zeltinger, Durgadas Bolikal, Joachim B. Kohn
  • Patent number: 11225628
    Abstract: The present invention relates to a coating composition that can produce an article having an inner surface and an outer surface, both of which are slippery, and a method for preparing the same. By using the coating composition according to the present invention, it is possible to produce the article having the inner surface and the outer surface, both of which are slippery, only with a simple process of molding and curing a polymer resin by the technique of the prior art. The article produced using the coating composition of the present invention can solve an ice removal on a surface of the machinery such as an aircraft and an automobile, a biofouling problem in a blood vessel, a problem requiring self-cleaning, and the like, and thus can be used in various industries.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: January 18, 2022
    Assignee: Industry-University Cooperation Foundation Hanyang University
    Inventors: Dong Rip Kim, Kang Won Lee, Ji Hoon Ahn, Yale Jeon
  • Patent number: 11214661
    Abstract: The present invention enables three-dimensional nanofabrication by isotropic shrinking of patterned hydrogels. A hydrogel is first expanded, the rate of expansion being controlled by the concentration of the crosslinker. The hydrogel is then infused with a reactive group and patterned in three dimensions using a photon beam through a limited-diffraction microscope. Functional particles or materials are then deposited on the pattern. The hydrogel is then shrunk and cleaved from the pattern.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: January 4, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Samuel G. Rodriques, Daniel Oran, Ruixuan Gao, Shoh Asano, Mark A. Skylar-Scott, Fei Chen, Paul W. Tillberg, Adam H. Marblestone, Edward S. Boyden
  • Patent number: 11045433
    Abstract: This invention discloses methods and composition to form biodegradable polymer implant arrays in the live tissue. Artificial cavities are created in the live tissue by using laser ablation, oscillating needle, microneedle array and other methods. The cavities are then filled with biodegradable polymer solution. The solvent in the polymer solution is dissipated in the tissue to form a biodegradable polymer implant in artificial cavities. The cavities and implants formed are arranged to form of an array of implants. The biodegradable polymer in the cavity can also be loaded with drug to form biodegradable drug delivery array in the live tissue.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: June 29, 2021
    Assignee: Pathak Holdings LLC
    Inventor: Chandrashekhar P. Pathak
  • Patent number: 11040170
    Abstract: Methods have been discovered that make it possible to continuously extrude tubes of P4HB and copolymers thereof. These methods allow tubes of P4HB and copolymers thereof to be produced without radial deformation of the tubes despite the slow crystallization of the polymer and copolymers. The methods can produce tubes of P4HB and copolymers thereof with tightly defined outside and inside diameters which are required for medical application. These tubes are produced by radial expansion at temperatures above the melting temperature of P4HB and copolymers thereof, and using low tube cooling temperatures and prolonged cooling times. The tubes made from P4HB and copolymers thereof are flexible, and can be prepared with high elongation to break values.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: June 22, 2021
    Assignee: TEPHA, INC.
    Inventors: Amit Ganatra, Said Rizk
  • Patent number: 11040505
    Abstract: The invention relates to an implantable medical device having a body comprising a composite material. The body has a variable cross section along a length, a first portion which forms a part of a surface of said body, and a packing portion. An insert is provided in the packing portion for providing an increased thickness to at least a part of the body.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: June 22, 2021
    Assignee: INVIBO COMPONENT MANUFACTURING LIMITED
    Inventors: Michael Burgess, Steven Lamorlniere
  • Patent number: 10982038
    Abstract: Among other things, the present disclosure provides compositions and methods for an elastomeric cross-linked polyester material. Such an elastomeric cross-linked polyester material, in some embodiments, comprises a plurality of polymeric units of the general formula (-A-B—)p, wherein p is an integer greater than 1; and a plurality of urethane cross-links each of which covalently links two polymeric units to one another, which two linked polymeric unit each had at least one free hydroxyl or amino group prior to formation of the crosslink.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: April 20, 2021
    Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC., BIOCANT-CENTER OF INNOVATION AND BIOTECHNOLOGY
    Inventors: Robert S. Langer, Jeffrey M. Karp, Maria Jose Maio Nunes-Pereira, Ben Ouyang, Lino da Silva Ferreira, Debanjan Sarkar
  • Patent number: 10933168
    Abstract: A double network hydrogel consists of a first network and a second network, where the first network is, or includes, a first polymer that is formed, at least in part, of —CH2—CH(OH)— units, and the second network is, or includes, a second polymer that is formed, at least in part, of carboxyl (COOH)-containing units or salts thereof, sulfonyl (SO3H)-containing units or salts thereof, and at least one of hydroxyl (OH)-containing units or amino (NH2)-containing units, where the hydrogel may be used as a cartilage replacement.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: March 2, 2021
    Assignee: POLY-MED, INC.
    Inventor: Michael Aaron Vaughn
  • Patent number: 10881613
    Abstract: The present invention relates to fumarate polymersomes. The polymersomes are capable of targeting immune cells and then hydrolysing to release the immunomodulatory compound fumarate. The polymersomes can thus be used methods for the treatment of prevention of diseases, including immune diseases such as multiple sclerosis and psoriasis.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: January 5, 2021
    Assignee: UCL BUSINESS LTD
    Inventor: Giuseppe Battaglia
  • Patent number: 10835644
    Abstract: The present invention provides surface-modified metals such as metal medical devices, e.g., guide wires, syringe needles, and metal tubes in medical devices or equipment, in which a lubricant layer is firmly bonded to the surface to impart lubricity to the surface, and further to improve the durability of the lubricant layer on the surface, thereby reducing deterioration of sliding properties, as well as methods for modifying a metal surface. The present invention relates to a surface-modified metal having a surface at least partially treated by polymerizing a monomer in the presence of a hydrogen abstraction type photopolymerization initiator.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: November 17, 2020
    Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventors: Yasuhisa Minagawa, Takefumi Nakashita
  • Patent number: 10829578
    Abstract: A mixture includes at least two radically curable compounds as a backbone resin, and is useful in reactive resins. In particular, the mixture reduces the viscosity of such reactive resin-containing mixtures and thus the dispensing forces required for ejecting the reactive resin components produced therefrom. The mixture also increases the performance of the reactive resins containing such mixtures and of the reactive resin components produced therefrom. Further, said reactive resins and the reactive resin components thereof are useful for construction purposes, in particular for chemical fastening.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: November 10, 2020
    Assignee: Hilti Aktiengesellschaft
    Inventors: Georg Nickerl, Jens Bunzen, Beate Gnass, Gerald Gaefke, Thomas Bürgel, Klaus Schaefers
  • Patent number: 10668182
    Abstract: The present invention relates to a method for preparing a medical material for replacing a hard tissue defect and a medical material produced therefrom. More specifically, in the present invention, powders of bioactive glass are press-molded, and are then subjected to a first heat treatment at a relatively low temperature below the glass transition temperature of bioactive glass. Then, the resultant is processed into a desired shape and then subjected to a second heat treatment at a temperature higher than the glass transition temperature of bioactive glass. Accordingly, the present invention provides a medical material which can be customized to a desired shape of a hard tissue defect in a living body and minimize thermal shock, and which is capable of exhibiting a bone fusion property, while overcoming the low compressive strength drawback of hydroxyapatite, which is an existing hard tissue replacement material currently in use.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: June 2, 2020
    Assignee: Bioalpha Corporation
    Inventors: Mi Young Ryu, Sung Nam Park, Jun Hyuk Seo, Hyun Seung Ryu
  • Patent number: 10653785
    Abstract: A collagen material is characterized in being constituted of collagen gel fragments. Furthermore, the collagen gel fragments may have an orientation. A method for producing a collagen material is characterized in comprising a step for preparing collagen gel fragments, a step for arranging the collagen gel fragments in a desired shape, and a step for drying the collagen gel fragments arranged in the desired shape. Moreover, in one embodiment of the method for producing a collagen material a step may include imparting an orientation to the collagen gel fragments.
    Type: Grant
    Filed: February 20, 2012
    Date of Patent: May 19, 2020
    Assignee: Atree, Inc.
    Inventors: Taro Saku, Yoshihiro Isobe, Takaoki Isobe
  • Patent number: 10486136
    Abstract: A substrate includes a double-network polymer system including a cross-linked, covalently-bonded polymer and a reversible, partially ionicly-bonded polymer, wherein the substrate has a moisture level less than or equal to 15 percent of the total weight of the substrate, wherein the substrate is porous, and wherein the substrate includes a latent retractive force. A method for manufacturing a substrate includes producing a double-network hydrogel including a cross-linked, covalently-bonded polymer and a reversible, ionicly-bonded polymer; elongating by force the double-network hydrogel in at least one direction; treating the double-network hydrogel with an organic solvent with a volatile and water-miscible organic solvent to replace a majority of water within the double-network hydrogel; evaporating the organic solvent while the double-network hydrogel is still elongated to form a substantially-dried double-network polymer system; and releasing the force to produce the substrate.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: November 26, 2019
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventor: Xuedong Song
  • Patent number: 10406503
    Abstract: A substrate includes a double-network polymer system including a cross-linked, covalently-bonded polymer and a reversible, partially ionicly-bonded polymer, wherein the substrate has a moisture level less than or equal to 15 percent of the total weight of the substrate, wherein the substrate is porous, and wherein the substrate includes a latent retractive force. A method for manufacturing a substrate includes producing a double-network hydrogel including a cross-linked, covalently-bonded polymer and a reversible, ionicly-bonded polymer; elongating by force the double-network hydrogel in at least one direction; treating the double-network hydrogel with an organic solvent with a volatile and water-miscible organic solvent to replace a majority of water within the double-network hydrogel; evaporating the organic solvent while the double-network hydrogel is still elongated to form a substantially-dried double-network polymer system; and releasing the force to produce the substrate.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: September 10, 2019
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventor: Xuedong Song
  • Patent number: 10392472
    Abstract: A biodegradable cross-linked polymer and methods of preparing same are provided. The biodegradable cross-linked polymer is formed from a biodegradable polymeric material having two or more arms, which is a random copolymer formed of a first monomer and a second monomer different from the first monomer. The first monomer is selected from the group consisting of L-lactide, DL-lactide, glycolid, ?-caprolactone, trimethylene carbonate, p-dioxanone, amino acid-derived polycarbonates and polyorthoesters. The second monomer is one or two selected from the group consisting of D-lactide, DL-lactide, glycolide, ?-caprolactone, trimethyl carbonate, salicylic acid, carbonates, amino acids and derivatives thereof. The biodegradable polymeric material has a molecular weight of from 5,000 to 1,200,000 and an intrinsic viscosity of from 0.1 to 9.0 dl/g. Each of the terminal groups on the arms of the biodegradable polymeric material is selected from the group consisting of hydroxyl amino and carboxyl groups.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: August 27, 2019
    Assignee: Shanghai Microport Medical (Group) Co., Ltd.
    Inventors: Hongyan Jiang, Qiyi Luo, Juan Hou, Yahong Kang, Jing Wang, Wei Wang
  • Patent number: 10253193
    Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: April 9, 2019
    Assignee: Surmodics, Inc.
    Inventors: Aleksey V. Kurdyumov, Dale G. Swan
  • Patent number: 10206946
    Abstract: Preferred embodiments relate to compositions of inherently radiopaque, biocompatible, bioresorbable polymeric particles and methods of using them for embolizing a body lumen.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: February 19, 2019
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Donald K. Brandom, Eric Schmid, Joan Zeltinger, Durgadas Bolikal, Joachim B. Kohn
  • Patent number: 10206773
    Abstract: An accommodating IOL comprises an optic adapted to focus light toward a retina of an eye, and a movement assembly coupled to the eye to provide effective accommodating movement, preferably axial movement, of the optic. At least a portion of the movement assembly is made from a material that is less stiff and/or more resilient than the material used to make the optic. Optionally, an outer ring or support portion made at least partially from either a relatively stiff material such as the material used in the optic or a relatively resilient material such as the material used in the movement assembly is also provided.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: February 19, 2019
    Assignee: Johnson & Johnson Surgical Vision, Inc.
    Inventors: Marlene L. Paul, Michael D. Lowery, Daniel G. Brady, Arlene Gwon
  • Patent number: 10207023
    Abstract: A preparation at least useful as a bone implant is provided, which contains a solid component including a lithium compound and a calcium compound. The preparation shows an anti-bacterial ability in comparison with a preparation contains the calcium compound but free of the lithium compound.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: February 19, 2019
    Assignee: NATIONAL CHENG KUNG UNIVERSITY
    Inventors: Jiin-Huey Chern-Lin, Chien-Ping Ju, Chang-Keng Chen, Bing-Chen Yang
  • Patent number: 10195308
    Abstract: Methods of preparing bioactive composites are described. Also described are methods of molding such composites. Shaped bodies comprising bioactive composites are further described.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: February 5, 2019
    Assignee: Orthovita, Inc.
    Inventors: James P. Murphy, Erik M. Erbe, Charanpreet S. Bagga, Marissa M. Conrad
  • Patent number: 10184031
    Abstract: Various embodiments disclosed relate to melt-stabilized materials including ultra high molecular weight polyethylene (UHMWPE), methods of making the same, and medical implants including the same. In various embodiments, the present invention provides a method of melt-stabilizing a material including UHMWPE. The method includes obtaining or providing a solid material including UHMWPE including a first concentration of free-radicals. The method includes coating at least part of the solid material with a liquid composition including at least one antioxidant, to provide a coated solid material. The method includes heating the coated solid material in an environment including oxygen, the heating being sufficient to melt at least part of the UHMWPE, to provide a heated material.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: January 22, 2019
    Assignee: Zimmer, Inc.
    Inventor: Dirk Pletcher
  • Patent number: 10106402
    Abstract: Disclosed are biomedical implants comprising surface-modified metal particles and biodegradable polymers; its use for suppressing inflammation; and a method for preparing a biomedical material, comprising: (a) modifying surface of basic metal particles with a polymer to obtain surface-modified metal particles; and (b) mixing the surface-modified metal particles with a biodegradable polymer, followed by manufacturing a biodegradable biomedical implant, or coating the resulting mixture on a conventional biomedical implant.
    Type: Grant
    Filed: January 6, 2011
    Date of Patent: October 23, 2018
    Assignee: Korea Institute of Science and Technology
    Inventors: Dong Keun Han, Kwi Deok Park, Jong Hee Kang, Bong Soo Lee, Ji Yeon Choi, Chang Hun Kum
  • Patent number: 10076538
    Abstract: In one aspect, methods of promoting bone growth are described herein. In some embodiments, a method of promoting bone growth described herein comprises promoting cell differentiation or phenotype progression in a population of bone cells by providing a citrate-presenting composition to the population of bone cells. In some embodiments, the citrate-presenting composition is provided to the bone cells at a first stage of cell development selected to obtain a first cell differentiation or phenotype progression. Additionally, in some cases, a second citrate-presenting composition is further provided to the bone cells at a second stage of cell development selected to obtain a second cell differentiation or phenotype progression.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: September 18, 2018
    Assignee: Board of Regents, The University of Texas System
    Inventor: Jian Yang
  • Patent number: 10035871
    Abstract: Among other things, the present disclosure provides compositions and methods for an elastomeric cross-linked polyester material. Such an elastomeric cross-linked polyester material, in some embodiments, comprises a plurality of polymeric units of the general formula (-A-B—)p, wherein p is an integer greater than 1; and a plurality of urethane cross-links each of which covalently links two polymeric units to one another, which two linked polymeric unit each had at least one free hydroxyl or amino group prior to formation of the crosslink.
    Type: Grant
    Filed: August 26, 2012
    Date of Patent: July 31, 2018
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., Biocant-Center of Innovation and Biotechnology
    Inventors: Robert S. Langer, Jeffrey M. Karp, Maria Jose Maio Nunes-Pereira, Ben Ouyang, Lino Da Silva Ferreira, Debanjan Sarkar
  • Patent number: 9913926
    Abstract: Described herein is the synthesis of adhesive complex coacervates and their use thereof. The adhesive complex coacervates are composed of a mixture of one or more polycations and one or more polyanions. The polycations and polyanions in the adhesive complex coacervate are crosslinked with one another by covalent bonds upon curing. The adhesive complex coacervates have several desirable features when compared to conventional bioadhesives, which are effective in water-based applications. The adhesive complex coacervates described herein exhibit good interfacial tension in water when applied to a substrate (i.e., they spread over the interface rather than being beaded up). Additionally, the ability of the complex coacervate to crosslink intermolecularly increases the cohesive strength of the adhesive complex coacervate.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: March 13, 2018
    Assignee: University of Utah Research Foundation
    Inventors: Russell J. Stewart, Hui Shao
  • Patent number: 9877808
    Abstract: The present invention provides a membrane for guided regeneration of bone and tissue comprising an organic base material and a new bone formation guide layer on one or both sides of the organic base material, the new bone formation guide layer containing a hydrophilic polymer and calcium phosphate.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: January 30, 2018
    Assignee: HITACHI CHEMICAL COMPANY, LTD.
    Inventors: Hiroko Noda, Tetsushi Maruyama
  • Patent number: 9855195
    Abstract: The present invention provides a dental curable composition used for dental filling restorative materials, dental crown prosthesis materials such as inlays, crowns, and bridges, materials for constructing anchor teeth, block materials for dental CAD/CAM, etc. More specifically, the present invention provides a dental curable composition comprising a curable resin (A), a porous inorganic filler (B), and a polymerization initiator (C), wherein the porous inorganic filler (B) comprises a silicon dioxide, and an oxide comprising at least one kind of the other metallic elements, and a ratio (I1/I2) of a maximum absorbance (I1) of 3730 to 3750 cm?1 to a maximum absorbance (I2) of 3000 to 3600 cm?1 in infrared absorption spectrum of the porous inorganic filler (B), is not less than 1 and not more than 3.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: January 2, 2018
    Assignees: KABUSHIKI KAISHA SHOFU, JGC CATALYSTS AND CHEMICALS LTD.
    Inventors: Shuhei Takahashi, Hidefumi Fujimura, Jun Uchida, Mitsuji Teramae, Kunio Hori, Naoyuki Enomoto
  • Patent number: 9839498
    Abstract: To provide a multilayer resin material for dental milling and machining, comprising an inorganic filler in a content of 40% by weight or more and a plurality of layers different in transparency and color tone from each other, wherein the thickness of the uppermost layer (U) and the thickness of the lowermost layer (L) are each 1 mm or more, the contrast ratios (uppermost layer: CU, lowermost layer: CL) as indices for the transparency of the uppermost layer (U) and the transparency of the lowermost layer (L) satisfy the following relations: 0.30?CU?0.60 0.55?CL?0.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: December 12, 2017
    Assignee: SHOFU INC.
    Inventors: Masanori Goto, Toshio Kitamura, Mitsuji Teramae
  • Patent number: 9833537
    Abstract: A calcium-based bone cement formula having a powder component and a setting liquid component with a liquid to powder ratio of 0.20 ml/g to 0.50 ml/g is provided, wherein the powder component includes tetracalcium phosphate. The bone cement formula further contains, based on the total weight of the bone cement formula, 0.01-1% of poly(acrylic acid) having a repeating unit of —(CH2—C(COOH)H)n-, wherein n=50-50000.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: December 5, 2017
    Assignee: NATIONAL CHENG KUNG UNIVERSITY
    Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju